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Relevant bibliographies by topics / Natural products – Structure

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Academic literature on the topic 'Natural products – Structure'

Author: Grafiati

Published: 4 June 2021

Last updated: 19 February 2022

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Journal articles on the topic "Natural products – Structure"

1

Blunt, John W., Anthony R. Carroll, Brent R. Copp, Rohan A. Davis, Robert A. Keyzers, and Michèle R. Prinsep. "Marine natural products." Natural Product Reports 35, no. 1 (2018): 8–53. http://dx.doi.org/10.1039/c7np00052a.

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This review of 2016 literature describes the structures and biological activities of 1277 new marine natural products and the structure revision and absolute configuration of previously reported MNPs. The chemical diversity of 28 609 MNPs reported since 1957 is also investigated and compared to that of approved drugs.

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Karageorgis, George, Daniel J. Foley, Luca Laraia, Susanne Brakmann, and Herbert Waldmann. "Pseudo Natural Products—Chemical Evolution of Natural Product Structure." Angewandte Chemie International Edition 60, no. 29 (March 23, 2021): 15705–23. http://dx.doi.org/10.1002/anie.202016575.

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Karageorgis, George, Daniel J. Foley, Luca Laraia, Susanne Brakmann, and Herbert Waldmann. "Pseudo Natural Products—Chemical Evolution of Natural Product Structure." Angewandte Chemie 133, no. 29 (March 23, 2021): 15837–55. http://dx.doi.org/10.1002/ange.202016575.

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Halász, Judit, Benjamin Podányi, Lelle Vasvári-Debreczy, Anna Szabó, Félix Hajdú, Zsolt Böcskei, Judit Hegedűs-Vajda, Andrea Győrbı́ró, and István Hermecz. "Structure Elucidation of Fumagillin-Related Natural Products." Tetrahedron 56, no. 51 (December 2000): 10081–85. http://dx.doi.org/10.1016/s0040-4020(00)00979-0.

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Garfield, William, and R. F. Keeler. "Structure-activity relations of teratogenic natural products." Pure and Applied Chemistry 66, no. 10-11 (January 1, 1994): 2407–10. http://dx.doi.org/10.1351/pac199466102407.

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Hansen, Poul Erik. "NMR of Natural Products as Potential Drugs." Molecules 26, no. 12 (June 21, 2021): 3763. http://dx.doi.org/10.3390/molecules26123763.

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This review outlines methods to investigate the structure of natural products with emphasis on intramolecular hydrogen bonding, tautomerism and ionic structures using NMR techniques. The focus is on 1H chemical shifts, isotope effects on chemical shifts and diffusion ordered spectroscopy. In addition, density functional theory calculations are performed to support NMR results. The review demonstrates how hydrogen bonding may lead to specific structures and how chemical equilibria, as well as tautomeric equilibria and ionic structures, can be detected. All these features are important for biological activity and a prerequisite for correct docking experiments and future use as drugs.

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Hanif, Novriyandi, Anggia Murni, Chiaki Tanaka, and Junichi Tanaka. "Marine Natural Products from Indonesian Waters." Marine Drugs 17, no. 6 (June 19, 2019): 364. http://dx.doi.org/10.3390/md17060364.

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Natural products are primal and have been a driver in the evolution of organic chemistry and ultimately in science. The chemical structures obtained from marine organisms are diverse, reflecting biodiversity of genes, species and ecosystems. Biodiversity is an extraordinary feature of life and provides benefits to humanity while promoting the importance of environment conservation. This review covers the literature on marine natural products (MNPs) discovered in Indonesian waters published from January 1970 to December 2017, and includes 732 original MNPs, 4 structures isolated for the first time but known to be synthetic entities, 34 structural revisions, 9 artifacts, and 4 proposed MNPs. Indonesian MNPs were found in 270 papers from 94 species, 106 genera, 64 families, 32 orders, 14 classes, 10 phyla, and 5 kingdoms. The emphasis is placed on the structures of organic molecules (original and revised), relevant biological activities, structure elucidation, chemical ecology aspects, biosynthesis, and bioorganic studies. Through the synthesis of past and future data, huge and partly undescribed biodiversity of marine tropical invertebrates and their importance for crucial societal benefits should greatly be appreciated.

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Krivdin, Leonid, and Valentin Semenov. "COMPUTATIONAL NMR OF NATURAL PRODUCTS." Modern Technologies and Scientific and Technological Progress 1, no. 1 (May 17, 2021): 38–39. http://dx.doi.org/10.36629/2686-9896-2021-1-1-38-39.

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A review of the literature data on the calculation of NMR parameters in a large number of natural compounds: alkaloids, terpenes, lactones, lactams, peptides is carried out in order to study their structure, as well as various stereochemical and stereoelectronic effects

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Sabatier, Jean-Marc. "Special Issue “Structure–Activity Relationship of Natural Products”." Molecules 22, no. 5 (April 27, 2017): 697. http://dx.doi.org/10.3390/molecules22050697.

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Miyashita, Kazuyuki, and Takeshi Imanishi. "Syntheses of Natural Products Having an Epoxyquinone Structure." Chemical Reviews 105, no. 12 (December 2005): 4515–36. http://dx.doi.org/10.1021/cr040613k.

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Dissertations / Theses on the topic "Natural products – Structure"

1

Li, Guoqiang. "Structure elucidation of bioactive natural products." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0004/NQ29469.pdf.

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Lorente, Crivillé Adriana. "Marine Natural Products. Synthesis and structure determination." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/279367.

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Natural products from terrestrial plants and microorganisms have long been a traditional source of drugs. For centuries humans have been looking on their environment for medicines to treat illnesses. But unlike terrestrial sources, marine habitat has not been so extensively studied; this field awaited refinements in technologies to collect the source organisms, and development of more advanced analytic techniques to better understand the more complex isolated compounds. Since 1950s this field has suffered an exponential push; considering that water covers around a 70% of the earth’s surface, and 32 of the 33 animal phyla are represented in aquatic media, marine habitat represents an extensive source of new bioactive molecules. Synthesis represents a powerful tool to use on our behalf for structure determination and supply of material for clinical tests on the development of new bioactive drugs. This thesis is focused on the synthesis and structure determination of bioactive compounds isolated from marine habitat: barmumycin and phormidolides B-D. Our strategy lied on the identification of the target by comparison of the available data from the natural product with data of our synthetic compounds. Barmumycin was isolated from an extract of a marine actinomycete and found to be cytotoxic against various human tumor cell lines. Macrolactone 1 was assigned on the basis of 1H and 13C NMR spectroscopy. Compound 1 was synthesized by two different routes. The main goal of both our synthesis is the alkylation of a weak nucleophilic aniline by this two different methods, which are based on a reductive amination and on a nucleophilic substitution. However, major spectroscopic differences between isolated barmumycin and 1 led to revision of the proposed structure. New structure 2, based on a pyrrolidine with an exocyclic double bond linked to an aromatic ring by an amide bond, was proposed. On the basis of the enantioselective synthesis of this new compound, and subsequent spectroscopic comparison of it to an authentic sample of barmumycin, the structure of the natural compound was indeed confirmed as that of 2. Polyketide macrolides are a class of secondary metabolites with interesting biological activities and complex structure and stereochemistry. A general overview of THF-containing macrolactones has been compiled, a class of compounds with high potential as drug candidates. Described are isolation, structure determination and the described synthesis up to 2012. Phormidolides B-D are polyketide macrolides related to oscillariolide and phormidolide A. These compounds were isolated from an active organic extract of a sponge of the Petrosiidae family and presented antitumor activity. The planar structure of Phormidolides B-D was determined on the basis of comparison of the spectra of the natural product with oscillariolide and phormidolide A and with the study of NMR spectra of isolated compounds. The relative stereochemistry of the macrocyclic core was only determined for 4 out of the 6 stereocenters of the macrocycle. The next target of this thesis is the enantioselective synthesis of the macrocyclic core of phormidolides B-D. The best synthetic pathway to the synthesis of the macrolide core of phormidolides B-D was selected with a not-stereoselective synthetic study. A strategy based on an olefin metathesis was discarded. On the other hand a strategy based on a Julia-Kocienski olefination completed the preparation of the macrocycle as a mixture of diasteromers. A robust and efficient methodology for the enantioselective synthesis of the macrolide core of phormidolides B-D was developed from the Julia-Kocienski olefination route. The strategy is versatile and can be used for the synthesis of the different diastereomers of the macrocycle making the appropriate changes in the starting materials and chiral inductors. The selective synthesis of the Z-trisubstituted double bond present on the macrocyclic core of phormidolides B-D was the objective of an optimization process that culminated with the use of a 1-(tert-butyl)tetrazolyl sulfone to succesfully afford the formation of the endocyclic alkene with excellent stereoselectivity. It is a fact that the discovery of New Molecular Entities (NME) requires innovation, new ideas and processes. Scientists have learned over the years how to overcome the problems often associated with marine derived natural products development and this work is one more example of this scenario.
Els productes naturals extrets de plantes i organismes terrestres han estat durant molts anys font d’inspiració per a la preparació de fàrmacs. Per contra el medi marí no ha rebut tanta atenció, la química dels productes naturals marins ha hagut d’esperar que les tecnologies es modernitzessin per facilitar la recol•lecció de mostres i la determinació estructural dels productes extrets, que presenten molta més complexitat estructural que els productes d’origen terrestre. En els últims 50 anys, aquest camp ha estat objecte de gran interès ja que representa una font de noves molècules bioactives, amb estructures i mecanismes d’acció diferents dels coneguts. En aquesta tesi s’ha treballat en dos projectes focalitzats en l’estudi de molècules d’origen marí com a fàrmacs, utilitzant la síntesi com a eina en els primers estadis de desenvolupament ja que la quantitat aïllada de les fonts naturals només serveix per fer una primera aproximació a estructura i activitat. La barmumicina és un producte natural amb activitat biològica del que s’ha confirmat l’estructura gràcies a la síntesi. El compost que es va determinar en la primera assignació s’ha obtingut per síntesi i s’ha comparat amb el producte natural duent a la conclusió que l’estructura no era la correcta. La reassignació i síntesi d’una nova molècula proposada ha confirmat la identitat d’aquest producte natural. Les formidolides B-D són productes naturals d’alta complexitat estructural. S’ha desenvolupat la síntesi del fragment macrocíclic de les formidolides B-D, abordant dues aproximacions per a la formació de l’alquè trisubstituit; una basada en una metàtesi d’olefines i l’altra en una olefinació de Julia-Kocienski. La segona ruta s’ha seleccionat com a ruta per adaptar a procediments estereoselectius. Adaptant aquesta estratègia, s’ha desenvolupat una metodologia que permet sintetitzar eficaçment i de forma enantioselectiva el macrocicle de les formidolides B-D; l’estratègia és versàtil, ja que canviant els materials de partida o els auxiliars quirals es pot dirigir la síntesi cap al diastereòmer desitjat. El punt clau de la síntesi ha estat la formació del doble enllaç trisubstituitZ amb bon rendiment i selectivitat, pel qual s’ha dut a terme una optimització del procés. S’han sintetitzat tres estereoisòmers i la comparació dels espectres de RMN del producte natural i els sintètics ha permès establir la configuració relativa dels esterocentres que presenta la macrolactona del producte natural. Els resultats presentats demostren la utilitat de la síntesi en el desenvolupament de productes naturals, ja sigui en la determinació d’estructura, estereoquímica o en la producció en sí.

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施麗琼 and Lai-king Sy. "Structure elucidation and oxidation chemistry of natural products." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B3123768X.

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Murphy, Annabel Christine. "Structure Elucidation and Synthesis of Natural Products." Thesis, University of Canterbury. Chemistry, 2008. http://hdl.handle.net/10092/1748.

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In this thesis, synthetic chemistry was used as a tool in the exploration of various aspects of natural products discovered by the natural products research group at the University of Canterbury. Work on the constituent amino acids and connectivity of the pteratides, a potently cytotoxic series of cyclodepsipeptides, had been completed before the beginning of this work (carried out by Miss C. Chen). The elucidation of the stereochemistry of the constituent amino acids was undertaken in this present work. The synthesis of all stereochemical entities of a number of unusual amino acids, which were either not available commercially or were expensive, was carried out, providing reference materials for comparison to the natural products. The synthesis of the diastereoisomers of one of these amino acids, 4-methylproline, was carried out by modification of literature procedures, which led to the development of an improved, concise and stereoselective synthesis. The hydrolysis of the natural products, derivatisation of the resultant hydrolysates, synthetic and commercial reference amino acids and HPLC analysis allowed the full stereochemical assignment of the pteratide series. The total synthesis of spiro-mamakone A, a cytotoxic polyketide isolated by Dr S. van der Sar, was undertaken. The synthesis was not successfully completed due to difficulties in the late-stage formation of a crucial enedione motif. However, very advanced intermediates were successfully synthesised. These synthetic analogues of the natural product were analysed for biological activity, allowing valuable insight into the structure-activity relationship, for example, demonstrating the importance of the enedione moiety to biological activity.

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Camou-Arriola, Fernando Alberto Josue. "Structure determinations of natural products and related molecules." Diss., The University of Arizona, 1989. http://hdl.handle.net/10150/184773.

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Structures were determined for 48 new natural products and several related compounds by NMR methods. One new natural product and two unnatural product structures were determined by X-ray diffraction. Molecular mechanics calculations on two indoles related to the neurotransmitter serotonin and on some synthetic cyclophanes were used to gain information about their preferred conformations. Considerable time is wasted redetermining the structures of known natural products when they are encountered in new sources. To help alleviate this problem, a database which searches on proton NMR chemical shifts was developed.

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Sy, Lai-king. "Structure elucidation and oxidation chemistry of natural products /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19737300.

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7

Reddy, Priyanka, and saipriyanka@gmail com. "Studies in Marine Natural Products." RMIT University. Applied Sciencez, 2009. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20091023.091658.

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The focus of this thesis was to study the chemotaxonomic relationship of selected southern Australian marine brown algae of the genera Cystophora and Sargassum. Consequently, this resulted in the isolation and structure elucidation of six new terpenoids from two southern Australian marine brown algae Cystophora moniliformis and Sargassum fallax together with 10 previously reported natural products. As a result of the re-isolation of these known secondary metabolites, updated and complete structural characterisation data could be provided for the first time for 7 of these compounds. Chemotaxonomic studies of Cystophora moniliformis resulted in the isolation of two new cyclic epimeric terpene diols moniliforminol A (3.25) and moniliforminol B (3.26), a new linear farnesyl acetone derivative (3.27) and the previously described terpenoids (3.19)-(3.24). This study also resulted in the first complete 2D NMR characterisation for compounds (3.21) to (3.24) as well as the first report of (3.24) occurring as a natural product. All structures were elucidated by detailed spectroscopic analysis with the relative configurations of (3.25) and (3.26) being established by selective 1D nOe NMR experiments. The proposed biosynthetic pathway for the above compounds has also been described. Chemical investigation of the Southern Australian marine brown alga Sargassum fallax resulted in the isolation of three new meroditerpenoids fallahydroquinone (4.8), fallaquinone (4.9) and fallachromenoic acid (4.10), together with the previously reported compounds sargaquinone (4.1) (isolated and identified in a mixture with sargaquinoic acid), sargahydroquinoic acid (4.2), sargaquinoic acid (4.3) and sargachromenol (4.11). As a result of this study the complete 2D NMR characterisation for sargahydroquinoic acid (4.2) and sargaquinoic acid (4.3) could also be reported for the first time. All structures were elucidated by detailed spectroscopic analysis. Sargahydroquinoic acid (4.2) and sargaquinoic acid (4.3) displayed moderate antitumour activity.

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Daoust, Julie. "Isolation and structure elucidation of bioactive marine natural products." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/37536.

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Clionamines A-D (2.6-2.9) are new aminosteroids isolated from South African specimens of the sponge Cliona celata. All four compounds (2.6-2.9) are activators of autophagy in MCF-7 cells. Autophagy is a catabolic process that plays an important role in maintaining cellular homeostasis. Autophagy is also directly involved in the removal of bacterial and viral antigens and in the development of cancerous tumors. The novel sesterterpenoid ansellone A (3.4) was isolated from the nudibranch Cadlina luteomarginata and was later found to have been sequestered by the nudibranch from the sponge Phorbas sp. Ansellone A (3.4) is an activator of the cAMP signalling pathway. Following the isolation of 3.4, the novel sesterterpenoids ansellones B-D (4.3-4.5) as well as alotaketal E (4.6) were isolated from the sponge Phorbas sp. and were found to also be activators of the cAMP signalling pathway. Several bacterial isolates were obtained from the sponge Phorbas sp. in order to investigate the possibility that the ansellones and the alotaketals isolated from this sponge were biosynthesized by a bacterial symbiont. Since these sesterterpenoids were activators of the cAMP signalling pathway, the investigation was conducted using bioassay guided fractionation of the bacterial isolates. The new meroterpenoid phorbasolic acid (5.1) was isolated, but no sesterterpenoids were found in the bacterial isolates. In an effort to identify molecules with antibiotic properties, a biological assay was designed to screen for inhibitors of the citrate synthase type II enzyme. One aspect of this enzyme that is of therapeutic interest is that Gram-negative bacteria possess a very different isoform of the enzyme than Gram-positive bacteria and eukaryotes. Therefore, an antibiotic specific to type II citrate synthase would target Gram-negative bacteria selectively. An extract from a culture of Bacillus pumillus inhibited the enzyme in the assay. Although the molecule responsible for this effect has yet to be identified, the new aliphatic amide 12-methyl tridecanamide (6.1) was isolated.

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Murphy, Brian Thacher. "Isolation and Structure Elucidation of Antiproliferative Natural Products from Madagascar." Diss., Virginia Tech, 2007. http://hdl.handle.net/10919/29599.

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As part of an ongoing search for bioactive natural products from the endemic rainforests and surrounding ocean in Madagascar, a total of four extracts were comprehensively studied and were found to contain novel and/or bioactive compounds. The following dissertation discusses the isolation, structure elucidation, and bioactivity studies of these isolates. The following compounds from plants of Madagascar's rainforest are discussed in the order they were studied: flavonoids and long-chain compounds from Schizolaena hystrix, a cyclohexene derivative and butenolides from Artabotrys madagascariensis, and limonoids from Malleastrum sp. From the Malagasy marine ascidian Trididemnum sp. collected in the Indian Ocean, the identification as well as the potential biosynthetic origin of polyketide derived bistramides is reported. n an attempt to explore other facets of natural products chemistry, the second part of this dissertation discusses the process of designing potential anticancer agents based on the scaffold of a natural product. The biomolecular target of these studies is an enzyme that is overexpressed in tumor cells, namely Cdc25B, whose inhibition catalyzes cell cycle arrest at the G2/M transition of the cell cycle. Several analogs of a potent Cdc25B inhibitor were synthesized and tested in the enzyme-based assay.
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Su, Qingxi. "Isolation and Structure Elucidation of Anticancer and Antimalarial Natural Products." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/72954.

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As part of an International Cooperative Biodiversity Group (ICBG) program and a collaborative research project with the Natural Products Discovery Institute, twenty plant extracts were investigated for their antiproliferative and antimalarial activities. Bioassay guided fractionation of thirteen extracts led to the identification of three new antiproliferative compounds, ethyl leptaulosides A-C (5.1-5.3), six new antiplasmodial compounds, apoplanesiacarpan A and B (2.4-2.5), (±)-rhodomyrtosone F (3.1), (±)-calliviminone C (3.2), 3α-angeloyloxy-15-hydroxylabda-7,13-dien-16,15-olid-18-oic acid (4.1), 3α-angeloyloxy-15-methoxylabda-7,13-dien-16,15-olid-18-oic acid (4.2), and twenty-six known compounds. The structures of these compounds were elucidated by using a combination of 1D (1H and 13C) and 2D NMR spectroscopy, mass spectrometry, UV, IR, CD, optical rotation, and chemical modifications. Compounds 5.1 and 5.2 showed moderate antiproliferative activity against the A2780 human ovarian cancer cell line assay with IC50 values of 3 uM and 10 uM, respectively. Compound 3.1 showed potent antiplasmodial activity with an IC50 value of 100 nM, while compounds 3.2 and 4.1 showed moderate antiplasmodial activity with IC50 values of 4 uM and 10 uM, respectively. The other compounds had IC50 values larger than 20 ug/mL, and were thus either inactive or only weakly active.
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Books on the topic "Natural products – Structure"

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Hoffmann, R. W. Hoffmann. Classical Methods in Structure Elucidation of Natural Products. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2018. http://dx.doi.org/10.1002/9783906390819.

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Chen, Haixia, and Min Zhang, eds. Structure and Health Effects of Natural Products on Diabetes Mellitus. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-8791-7.

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International Workshop on Isolation and Structure Elucidation of Natural Products using Spectroscopic Techniques (1987 Karachi, Pakistan). Recent advances in natural product chemistry: Proceedings of the International Workshop on Isolation and Structure Elucidation of Natural Products using Spectroscopic Techniques, Karachi, Pakistan, 10-16 January 1987. Karachi, Pakistan: A. Rahman, 1987.

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Yu, Margaret. Applying 2D NMR methods to the structural elucidation of complex natural products. Ottawa: National Library of Canada = Bibliothèque nationale du Canada, 1997.

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service), SpringerLink (Online, ed. Advanced Ceramic Technologies & Products. Tokyo: Springer Japan, 2012.

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Maryland. Dept. of Natural Resources. Assessment of water quality impacts associated with use of coal combustion products as structural fill at the BBSS site. [Annapolis, Md.]: Maryland Dept. of Natural Resources, 2007.

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United States. Bureau of Land Management and Geological Survey (U.S.), eds. Assessment of ecological conditions and potential effects of water produced from coalbed natural gas development on biological communities in streams of the Powder River structural basin, Wyoming and Montana, 2005-08. Reston, Va: U.S. Dept. of the Interior, U.S. Geological Survey, 2010.

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Marjorie, Burns, and Sargent Sam C, eds. Cataclysms on the Columbia: A layman's guide to the features produced by the catastrophic Bretz floods in the Pacific Northwest. 2nd ed. Portland, Or: Timber Press, 1991.

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Marjorie, Burns, and Sargent Sam C, eds. Cataclysms on the Columbia: A layman's guide to the features produced by the catastrophic Bretz floods in the Pacific Northwest. Portland, Or: Timber Press, 1986.

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Ontario. Esquisse de cours 12e année: Le droit canadien et international cln4u cours préuniversitaire. Vanier, Ont: CFORP, 2002.

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Book chapters on the topic "Natural products – Structure"

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Bruegger, Joel, Grace Caldara, Joris Beld, Michael D. Burkart, and Shiou-Chuan Sheryl Tsai. "Polyketide Synthase: Sequence, Structure, and Function." In Natural Products, 219–43. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2014. http://dx.doi.org/10.1002/9781118794623.ch12.

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Paquette, Leo A., and Annette M. Doherty. "Natural Products Chemistry." In Reactivity and Structure Concepts in Organic Chemistry, 107–11. Berlin, Heidelberg: Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-72598-2_6.

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Baltz, Richard H. "Daptomycin and A54145: Structure-Activity Relationship (SAR) Studies Enabled by Combinatorial Biosynthesis." In Natural Products, 433–54. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2014. http://dx.doi.org/10.1002/9781118794623.ch23.

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Antoszczak, Michał, Jacek Rutkowski, and Adam Huczyński. "Structure and Biological Activity of Polyether Ionophores and Their Semisynthetic Derivatives." In Bioactive Natural Products, 107–70. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2015. http://dx.doi.org/10.1002/9783527684403.ch6.

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Paquette, Leo A., and Annette M. Doherty. "Synthesis of Diquinane Natural Products." In Reactivity and Structure Concepts in Organic Chemistry, 127–68. Berlin, Heidelberg: Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-72598-2_8.

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Paquette, Leo A., and Annette M. Doherty. "Synthesis of Triquinane Natural Products." In Reactivity and Structure Concepts in Organic Chemistry, 169–208. Berlin, Heidelberg: Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-72598-2_9.

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Rodríguez, Jaime, Phillip Crews, and Marcel Jaspars. "Contemporary Strategies in Natural Products Structure Elucidation." In Handbook of Marine Natural Products, 423–517. Dordrecht: Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-90-481-3834-0_7.

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Cordell, Geoffrey A., Gábor Blaskó, Matthias O. Hamburger, Ze-Yuan Luo, Helga Shieh, David C. Lankin, and Hildebert Wagner. "NMR Techniques for the Structure Elucidation and Conformational Analysis of Natural Products." In Natural Products Chemistry III, 19–42. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-74017-6_2.

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Irie, Kazuhiro, and Koichi Koshimizu. "The Indole Alkaloid Tumor Promoter Teleocidins as Epstein-Barr Virus Inducers: Structure, Biosynthesis and Structure-Activity Relationship." In Natural Products as Antiviral Agents, 257–73. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3414-3_13.

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Snyder, J., R. Breuning, F. Derguini, and K. Nakanishi. "Fractionation and Proof of Structure of Natural Products." In Natural Products of Woody Plants, 27–124. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74075-6_3.

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Conference papers on the topic "Natural products – Structure"

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Ouali, Sami. "Resolving Code Smells in Software Product Line using Refactoring and Reverse Engineering." In 9th International Conference on Natural Language Processing (NLP 2020). AIRCC Publishing Corporation, 2020. http://dx.doi.org/10.5121/csit.2020.101422.

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Software Product Lines (SPL) are recognized as a successful approach to reuse in software development. Its purpose is to reduce production costs. This approach allows products to be different with respect of particular characteristics and constraints in order to cover different markets. Software Product Line engineering is the production process in product lines. It exploits the commonalities between software products, but also to preserve the ability to vary the functionality between these products. Sometimes, an inappropriate implementation of SPL during this process can conduct to code smells or code anomalies. Code smells are considered as problems in source code which can have an impact on the quality of the derived products of an SPL. The same problem can be present in many derived products from an SPL due to reuse. A possible solution to this problem can be the refactoring which can improve the internal structure of source code without altering external behavior. This paper proposes an approach for building SPL from source code. Its purpose is to reduce code smells in the obtained SPL using refactoring source code. Another part of the approach consists on obtained SPL’s design based on reverse engineering.

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Antipenko, Vladimir R., Svetlana S. Yanovskaya, Oxana N. Fedyaeva, and Anatoly A. Vostrikov. "Comparative characteristics of low-molecular nitrogen bases in sulfur rich natural asphaltite and the products of its conversion in supercritical water." In PROCEEDINGS OF THE ADVANCED MATERIALS WITH HIERARCHICAL STRUCTURE FOR NEW TECHNOLOGIES AND RELIABLE STRUCTURES. Author(s), 2018. http://dx.doi.org/10.1063/1.5083264.

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Antipenko, Vladimir R., Oxana N. Fedyaeva, Andrey A. Grinko, and Anatoly A. Vostrikov. "Structural parameters of resins and asphaltenes of natural asphaltite and products of its conversion in supercritical water." In PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON PHYSICAL MESOMECHANICS. MATERIALS WITH MULTILEVEL HIERARCHICAL STRUCTURE AND INTELLIGENT MANUFACTURING TECHNOLOGY. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0034692.

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Brito, Jordana T., Lucas H. Martorano, Ana Carolina F. de Albuquerque, Carlos Magno Rocha Ribeiro, Rodolfo Goetze Fiorot, José Walkimar de Mesquita Carneiro, Alessandra L. Valverde, and Fernando Martins dos Santos Junior. "ESPECTROSCOPIA COMPUTACIONAL APLICADA AO REASSINALAMENTO ESTRUTURAL DE MOLÉCULAS QUIRAIS: HELIANNUOL L." In VIII Simpósio de Estrutura Eletrônica e Dinâmica Molecular. Universidade de Brasília, 2020. http://dx.doi.org/10.21826/viiiseedmol202025.

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In the past, structure determination of natural products was an arduous process depending almost entirely on chemical synthesis, mainly by derivatization and degradation processes, taking years of effort. Recently, structural elucidation of natural products has undergone a revolution. Nowadays, with the combined use of different advanced spectroscopic methods, it became possible to completely assign the structure of natural products using small amounts of sample. However, despite the extraordinary ongoing advances in spectroscopy, the mischaracterization of natural products has been and remains a recurrent problem, especially in the presence of several chiral centers. The misinterpretation of NMR data has resulted in frequent reports addressing the issue of structural reassignment. In this context, a great effort has been devoted to the development of quantum chemical calculations to predict NMR parameters, and thus achieve a more accurate spectral interpretation. In this work, we applied a protocol for theoretical calculations of 1H NMR chemical shifts in order to establish the correct and unequivocal structure of Helianuol L, a member of the Heliannuol’s class, isolated from Helianthus annus. These secondary metabolites present a broad spectrum of biological activities, including the allelochemical activity, making them promising candidates as natural agrochemicals. It is worth mentioning, however, that the process of elucidating the structure of Heliannuol L was based on structural correlations with molecules already known in the literature, where few stereochemical analyses were performed. In this way, based on the fact that other compounds of the Heliannuol’s class had their structure previously reassigned, the verification of the proposed structure of Heliannuol L becomes of great importance.

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Robien, W. "Computer-assisted fully automatic structure revision of organic natural products based on their C13-NMR data using the CSEARCH-protocol." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3399702.

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Щербакова, Наталья, Заур Хапцев, Андрей Захаревич, Сергей Вениг, and Виктор Сержантов. "Biotechnological bases of use of natural mineral glauconite in soil-forming processes at development of technogenic massifs and liquidation of enterprises on extraction of minerals." In Mineralogical and technological appraisal of new types of mineral products. Petrozavodsk: Karelian Research Center of RAS, 2019. http://dx.doi.org/10.17076/tm13_9.

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To initiate the process of soil formation, it is necessary to introduce a culture of microorganisms capable of improving mineral nutrition, plant growth and resistance to adverse factors, regardless of the mineralogical composition of the surface. The advantage of the developed methods is the multifunctionality of the sorbent, which is an abiotic catalyst: the dangerous agent binds physically due to the formed fine-porous structure, and chemically due to the ion exchange processes occurring due to the nature of the layered glauconite silicate. The viability of immobilized glauconite bacterial cells of Agrobacterium radiobacter 204, Rhizobium leguminosarumbiovartrifolii, Flaviobacterium L 30 fulvum, Pseudomonas aureofaciens 1393 BS, amounted to no less than 4 months., while the original biological products are stored no more than 1 month. Key words: glauconite, sorbent, sorption capacity, heavy metals, microorganisms, immobilization on inorganic carriers.

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Kaneko, Hiroki, and Atsushi Sakuma. "Evaluation of Heat Transfer Kinetics on Layers of Air-Rich Soft Materials in Their Natural State." In ASME 2018 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/imece2018-87268.

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Air-rich soft materials are widely used in textile products, such as clothes and towels, because they exhibit good heat-retaining properties. Quantification of the heat-retaining properties of materials is necessary for product design engineering. Here, the behavior of heat transfer in the layer structure of the material is evaluated to formulate its kinetics. Such evaluation can address the barriers to appropriate design. The heat transfer kinetics of the multilayered structure of the materials are evaluated by assessing the surface temperature of the outer layers. The evaluation equation for kinetics is formulated by applying the fundamental relationship of heat transfer, which is represented by thermal conductivity and the heat transfer coefficient. In the experimental evaluation, a simple wind tunnel was developed using a blower, hot plate, and digital radiation temperature sensor. The temperature of the hot plate was set at three levels. In the evaluation of surface temperature, the quantity of infrared ray was measured using the digital radiation temperature sensor, because it could be used without mechanically influencing the specimen. The surface temperature of the materials was measured by changing the number of layers from one to eight. In the evaluation of heat transfer kinetics, some properties of the conductivity and the transfer were identified by the formulated relationship for the kinetics of the layered structure and the numerical technique of inverse analysis. It was found that the heat conductivity of the material and heat conductivities between the layers can be identified by the examination of surface temperature variation caused by the change in the number of layers. Then, the crush effect of air-rich structures can be assessed by compressing the material and then analyzing the behavior change in heat transfer caused by the crush. The difference between the observed results and those obtained without the crush of air-rich structure was significant. Thus, we concluded that the physical properties of heat transfer in a multilayered structure of air-rich soft materials can be identified using the surface temperature change in the material resulting from the number of layers. Therefore, it is important to measure its behavior without the crush of the air-rich structure to evaluate the most natural state of the material appropriately.

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Bobba, Mohan K., Priya Gopalakrishnan, Karthik Periagaram, and Jerry M. Seitzman. "Flame Structure and Stabilization Mechanisms in a Stagnation Point Reverse Flow Combustor." In ASME Turbo Expo 2007: Power for Land, Sea, and Air. ASMEDC, 2007. http://dx.doi.org/10.1115/gt2007-28231.

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A novel combustor design, referred to as a Stagnation Point Reverse Flow (SPRF) combustor, was recently developed to overcome the stability issues encountered with most lean premixed combustion systems. The SPRF combustor is able to operate stably at very lean fuel-air mixtures with low NOx emissions. The reverse flow configuration causes the flow to stagnate and hot products to reverse and leave the combustor. The highly turbulent stagnation zone and internal recirculation of hot product gases facilitates robust flame stabilization in the SPRF combustor at very lean conditions over a range of loadings. Various optical diagnostic techniques are employed to investigate the flame characteristics of a SPRF combustor operating with premixed natural gas and air at atmospheric pressure. These include simultaneous Planar Laser-Induced Fluorescence (PLIF) imaging of OH radicals, chemiluminescence imaging, Spontaneous Raman Scattering. The results indicate that the combustor has two stabilization regions, with the primary region downstream of the injector where there are low average velocities and high turbulence levels where most of the heat release occurs. High turbulence level in the shear layers lead to increased product recirculation levels, elevating the reaction rates and thereby, the combustor stability. The effect of product entrainment on the chemical timescales and the flame structure is quantified using simple reactor models. Turbulent flame structure analysis indicates that the flame is primarily in the thin reaction zones regime throughout the combustor. The flame tends to become more flamelet like, however, for increasing distance from the injector.

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Han, Sangmin, Junhong Bae, Kihun Joh, Yongsuk Suh, and Jae-Kwang Eom. "Assessing Structural Safety of Inner Hull Structure Under Cryogenic Temperature." In ASME 2011 30th International Conference on Ocean, Offshore and Arctic Engineering. ASMEDC, 2011. http://dx.doi.org/10.1115/omae2011-50331.

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The market of LNG (Liquefied Natural Gas) carrier is continuously in a prosperous condition, and a lot of LNG vessels are being built in many shipyards. Membrane-type MARK-III LNG CCS (Cargo Containment System) is used more and more in the construction of LNG carrier, and it has already taken considerable market share among the various LNG CCS products. This paper deals with a study on structural safety of LNG carrier whose inner hull structure is affected by cryogenic temperature of LNG. If the primary and secondary barriers are failed simultaneously, the inner hull structure comes to be in direct contact with LNG. It is well known that the cryogenic temperature exposes the inner hull structure to fatal risk of structural failure due to brittle fracture, but nevertheless it is quite difficult to find a precedent research which explains the degree of risk and severity with due consideration of the consequence caused by structural failure of inner hull. The heat transfer test has been performed using the specimen appropriate to realize test scenario while considering cryogenic liquid flow from primary and secondary barrier into inner hull structure, and at the same time, the specimen has been tested by applying proper deformation so as to examine the structural behavior of inner hull structure under cryogenic condition. The heat transfer analysis has been performed to simulate and verify the heat transfer test, and consequently it is possible to obtain actual distribution of temperature in the inner hull structure exposed to cryogenic temperature. The structural analysis has been performed to evaluate the damage of inner hull structure and as a result to assess overall decrease of hull girder strength of LNG carrier. Finally, consequence of the decrease of global strength has been discussed.

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Božičkovic, Ivana, Vesna Davidovic, Radomir Savic, Vladimir Živkovic, Stefan Stepic, and Vladan Đermanovic. "UTICAJ FIZIČKE AKTIVNOSTI NA HISTOLOŠKE KARAKTERISTIKE MIŠIĆA DOMAĆIH ŽIVOTINJA." In SAVETOVANJE o biotehnologiji sa međunarodnim učešćem. University of Kragujevac, Faculty of Agronomy, 2021. http://dx.doi.org/10.46793/sbt26.189b.

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Meat is a product formed from skeletal muscles of animals through different biochemical processes following rigor mortis. Therefore, characteristics of muscle tissue, its structure, number, diameter and percentage of different muscle fiber types would greatly determine the quantity and the quality of meat. Having in mind that selection and nutrition led to nearly a maximum in meat production, and consumers are having higher and higher demands for „organic“ products, products from more natural production, their concern for animal welfare is rising, the implementation of physical activity in animal rearing could be of more importance in the future. Physical activity could imply outdoor systems, or semi-confinement systems with enriched environment. Also, the impact of this factor could be of higher importance in pigs and chicken, where intensive selection towards lean meat content increased the number of glycolytic fibers in muscles, leading to more pronounced problems with meat quality (PSE meat).

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Reports on the topic "Natural products – Structure"

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Illanes, Gastón, and Sarah Moshary. Market Structure and Product Assortment: Evidence from a Natural Experiment in Liquor Licensure. Cambridge, MA: National Bureau of Economic Research, April 2020. http://dx.doi.org/10.3386/w27016.

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Leavy, Michelle B., Danielle Cooke, Sarah Hajjar, Erik Bikelman, Bailey Egan, Diana Clarke, Debbie Gibson, Barbara Casanova, and Richard Gliklich. Outcome Measure Harmonization and Data Infrastructure for Patient-Centered Outcomes Research in Depression: Report on Registry Configuration. Agency for Healthcare Research and Quality (AHRQ), November 2020. http://dx.doi.org/10.23970/ahrqepcregistryoutcome.

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Background: Major depressive disorder is a common mental disorder. Many pressing questions regarding depression treatment and outcomes exist, and new, efficient research approaches are necessary to address them. The primary objective of this project is to demonstrate the feasibility and value of capturing the harmonized depression outcome measures in the clinical workflow and submitting these data to different registries. Secondary objectives include demonstrating the feasibility of using these data for patient-centered outcomes research and developing a toolkit to support registries interested in sharing data with external researchers. Methods: The harmonized outcome measures for depression were developed through a multi-stakeholder, consensus-based process supported by AHRQ. For this implementation effort, the PRIME Registry, sponsored by the American Board of Family Medicine, and PsychPRO, sponsored by the American Psychiatric Association, each recruited 10 pilot sites from existing registry sites, added the harmonized measures to the registry platform, and submitted the project for institutional review board review Results: The process of preparing each registry to calculate the harmonized measures produced three major findings. First, some clarifications were necessary to make the harmonized definitions operational. Second, some data necessary for the measures are not routinely captured in structured form (e.g., PHQ-9 item 9, adverse events, suicide ideation and behavior, and mortality data). Finally, capture of the PHQ-9 requires operational and technical modifications. The next phase of this project will focus collection of the baseline and follow-up PHQ-9s, as well as other supporting clinical documentation. In parallel to the data collection process, the project team will examine the feasibility of using natural language processing to extract information on PHQ-9 scores, adverse events, and suicidal behaviors from unstructured data. Conclusion: This pilot project represents the first practical implementation of the harmonized outcome measures for depression. Initial results indicate that it is feasible to calculate the measures within the two patient registries, although some challenges were encountered related to the harmonized definition specifications, the availability of the necessary data, and the clinical workflow for collecting the PHQ-9. The ongoing data collection period, combined with an evaluation of the utility of natural language processing for these measures, will produce more information about the practical challenges, value, and burden of using the harmonized measures in the primary care and mental health setting. These findings will be useful to inform future implementations of the harmonized depression outcome measures.

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Disaster Assistance for Farmers. USDA Caribbean Climate Hub, October 2017. http://dx.doi.org/10.32747/2018.6941246.ch.

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Hurricanes Irma and María caused many U.S. Virgin Island and Puerto Rican producers to suffer livestock and crop losses, and structural damages to their operations. The United States Department of Agriculture (USDA) is committed to helping eligible producers recuperate after these natural disasters.The United States Department of Agriculture (USDA) is committed to helping eligible producers recuperate after these natural disasters.

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