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1

Ríos, José Julián, María Roca, and Antonio Pérez-Gálvez. "Systematic HPLC/ESI-High Resolution-qTOF-MS Methodology for Metabolomic Studies in Nonfluorescent Chlorophyll Catabolites Pathway." Journal of Analytical Methods in Chemistry 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/490627.

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Characterization of nonfluorescent chlorophyll catabolites (NCCs) and dioxobilane-type nonfluorescent chlorophyll catabolite (DNCC) in peel extracts of ripened lemon fruits (Citrus limonL.) was performed by HPLC/ESI-high resolution-qTOF-MS method. Compounds were identified in samples on the basis of measured accurate mass, isotopic pattern, and characteristic fragmentation profile with an implemented software postprocessing routine. Three NCC structures already identified in other vegetal tissues were present in the lemon fruit peels (Cl-NCC1;Cl-NCC2;Cl-NCC4) while a new structure not defined
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2

Liu, Qi, Weiping Hao, Yongguang Yang, et al. "Effects of Size and Dispersity of Microcrystalline Celluloses on Size, Structure and Stability of Nanocrystalline Celluloses Extracted by Acid Hydrolysis." Nano LIFE 04, no. 04 (2014): 1441014. http://dx.doi.org/10.1142/s1793984414410141.

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Nanocrystalline celluloses (NCCs) were separated from four commercial microcrystalline celluloses (MCCs) by an acid hydrolysis–sonication treatment. Transmission electron microscopy (TEM), atomic force microscopy (AFM), Fourier transform infrared (FTIR) spectrum, X-ray diffraction (XRD) and thermogravimetric analysis (TGA) were conducted to investigate the NCCs. MCCs with different morphologies and particle sizes showed different aggregation degrees. The aggregation of MCCs followed the order MCC1 > MCC3 > MCC2 > MCC4, which is the same order of the heights of the resulting NCCs. The
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3

Fu, Ming, Vincent Chi Hang Lui, Mai Har Sham, Vassilis Pachnis, and Paul Kwong Hang Tam. "Sonic hedgehog regulates the proliferation, differentiation, and migration of enteric neural crest cells in gut." Journal of Cell Biology 166, no. 5 (2004): 673–84. http://dx.doi.org/10.1083/jcb.200401077.

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Enteric neural crest cells (NCCs) migrate and colonize the entire gut and proliferate and differentiate into neurons and glia of the enteric nervous system in vertebrate embryos. We have investigated the mitogenic and morphogenic functions of Sonic hedgehog (Shh) on enteric NCCs in cell and organ culture. Enteric NCCs expressed Shh receptor Patched and transcripts encoding the Shh signal transducer (Gli1). Shh promoted the proliferation and inhibited the differentiation of NCCs. The pro-neurogenic effect of glial cell line–derived neurotrophic factor (GDNF) on NCCs was abolished by Shh. In gut
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4

Frye, Harrison. "The Ethics of Noncompete Clauses." Business Ethics Quarterly 30, no. 2 (2020): 229–49. http://dx.doi.org/10.1017/beq.2019.30.

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ABSTRACTNoncompete clauses (NCCs), or agreements by employees to not work for a competitor or start a competing business, have recently faced increased public scrutiny and criticism. This article provides a qualified defense of NCCs. I focus on the argument that NCCs should be banned because they unfairly restrict the options of employees. I argue that this argument fails because it neglects the economist Thomas Schelling’s insight that limiting exit options can be beneficial for a person. This employee-based defense of NCCs does not absolve all their uses, but it does give us a rough test for
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5

Golding, Jon P., Monica Dixon, and Martin Gassmann. "Cues from neuroepithelium and surface ectoderm maintain neural crest-free regions within cranial mesenchyme of the developing chick." Development 129, no. 5 (2002): 1095–105. http://dx.doi.org/10.1242/dev.129.5.1095.

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Within the developing vertebrate head, neural crest cells (NCCs) migrate from the dorsal surface of the hindbrain into the mesenchyme adjacent to rhombomeres (r)1 plus r2, r4 and r6 in three segregated streams. NCCs do not enter the intervening mesenchyme adjacent to r3 or r5, suggesting that these regions contain a NCC-repulsive activity. We have used surgical manipulations in the chick to demonstrate that r3 neuroepithelium and its overlying surface ectoderm independently help maintain the NCC-free zone within r3 mesenchyme. In the absence of r3, subpopulations of NCCs enter r3 mesenchyme in
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6

Ratna, Ratna, Nasrul Arahman, Agus Arip Munawar, and Sri Aprilia. "Extraction, Isolation, and Characterization of Nanocrystalline Cellulose from <i>Barangan</i> Banana (<i>Musa acuminata</i> L.) Peduncles Waste." Indonesian Journal of Chemistry 23, no. 1 (2022): 73. http://dx.doi.org/10.22146/ijc.74718.

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Microwave-assisted acid hydrolysis has an impact on the characteristics of nanocrystalline cellulose (NCCs). In this study, NCCs was prepared from banana peduncles through hydrolysis of sulfuric acid (concentrations of 1, 2, and 3 M) and hydrolysis time (0.5 and 1.5 h) assisted by microwave and ultrasonic energy to obtain the best NCCs. The characterization of NCCs properties, namely, yield, morphology, functional groups, crystallinity, heat resistance, particle size, and color. The results showed that the yield of NCCs decreased as sulfuric acid concentration and the time length of hydrolysis
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7

Casillas, Rogelio Ramírez, Maria del Carmen López-López, Bruno Becerra-Aguilar, Florentina Dávalos-Olivares, and Kestur Gundappa Satyanarayana. "Preparation and characterization of cellulose nanocrystals using soluble grade cellulose from acid hydrolysis of huizache (Acacia farnesiana L. Willd.)." BioResources 14, no. 2 (2019): 3319–38. http://dx.doi.org/10.15376/biores.14.2.3319-3338.

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High purity cellulose nanocrystals (NCCs) were obtained through the generation of various nanoparticle suspensions from different hydrolysis conditions of soluble grade cellulose (α-cellulose) prepared from huizache wood (Acacia farnesiana L. Willd.). These NCCs exhibited different surface morphologies and properties. Hydrolysis was carried out using both sulfuric and hydrochloric acids, while the methodology was based on 23 factorial designs of experiments. The obtained nanocrystals were characterized for particle size distribution, morphology, size of the NCCs, residual surface charge of the
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8

Major, Travis, and Harold Torrence. "Escape from Noun Complement Clauses in Avatime." Languages 9, no. 11 (2024): 339. http://dx.doi.org/10.3390/languages9110339.

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This paper discusses the status of island phenomena in Avatime, an endangered Kwa language of Ghana. We focus on clausal adjuncts, specifically noun complement clauses (NCCs). We show that while standard adjuncts are strong islands in Avatime, NCCs allow argument extraction. We suggest that this is related to the fact that NCCs in Avatime are not a type of relative clause. Instead, NCCs involve a kind of serial verb construction, which independently allows for extraction.
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9

Erhardt, Shannon, and Jun Wang. "Cardiac Neural Crest and Cardiac Regeneration." Cells 12, no. 1 (2022): 111. http://dx.doi.org/10.3390/cells12010111.

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Neural crest cells (NCCs) are a vertebrate-specific, multipotent stem cell population that have the ability to migrate and differentiate into various cell populations throughout the embryo during embryogenesis. The heart is a muscular and complex organ whose primary function is to pump blood and nutrients throughout the body. Mammalian hearts, such as those of humans, lose their regenerative ability shortly after birth. However, a few vertebrate species, such as zebrafish, have the ability to self-repair/regenerate after cardiac damage. Recent research has discovered the potential functional a
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10

Dobbins, Maureen, Alejandra Dubois, Donna Atkinson, et al. "Nimble, efficient and evolving: the rapid response of the National Collaborating Centres to COVID-19 in Canada." Health Promotion and Chronic Disease Prevention in Canada 41, no. 5 (2021): 165–70. http://dx.doi.org/10.24095/hpcdp.41.5.03.

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Abstract Since December 2019, there has been a global explosion of research on COVID-19. In Canada, the six National Collaborating Centres (NCCs) for Public Health form one of the central pillars supporting evidence-informed decision making by gathering, synthesizing and translating emerging findings. Funded by the Public Health Agency of Canada and located across Canada, the six NCCs promote and support the use of scientific research and other knowledges to strengthen public health practice, programs and policies. This paper offers an overview of the NCCs as an example of public health knowle
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11

Kennedy, Alexander, Syilfia Regita Mustika, and William Hartato Surya. "Non-Compete Clauses in Contracts and Antitrust Law in Indonesia." Journal of Legal and Cultural Analytics 4, no. 1 (2025): 603–22. https://doi.org/10.55927/jlca.v4i1.13551.

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This study examines non-compete clauses (NCCs) in franchise agreements within Indonesia’s legal framework, focusing on their alignment with antitrust laws and implications for market competition and entrepreneurship. By analyzing statutory provisions, judicial precedents, and doctrinal interpretations, this normative juridical research evaluates the proportionality and enforceability of NCCs under Indonesian contract and labor law. The study highlights the restrictive nature of NCCs, their potential to hinder economic mobility, and the challenges posed by the lack of regulatory clarity. Findin
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Smith, Simon. "Neo-classical compounds in student writing: a corpus-based study." Verbum 34, no. 2 (2012): 277–96. https://doi.org/10.3406/verbu.2012.989.

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Abstract This article examines the use of neo-classical compounds (NCCs) in the British Academic Written English corpus (BAWE). Academic texts written by students from both English and other linguistic backgrounds, in three academic disciplines (English, Business Studies and Engineering) are studied, and the distribution of NCCs among these categories is discussed. It is shown that NCC distribution in the three disciplines differs considerably, and that native English speaker usage of NCCs is at variance with that of non-native speakers, but that usage among different L1 groups is fairly const
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13

Soria Aguirre, Johanna Maribel, and Eszter Tormáné Kovács. "Contribution of nature conservation related citizen science projects to learning, attitude and behavioral change of participants." Review on Agriculture and Rural Development 12, no. 1-2 (2023): 27–36. http://dx.doi.org/10.14232/rard.2023.1-2.27-36.

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Nature Conservation related Citizen Science (NCCS) is an emerging area of research and practice where volunteers take part in a scientific process, usually focusing on data gathering or monitoring for conservation purposes. We present a review of studies where questionnaire surveys were used to measure the impacts of NCCS projects on the learning, attitude and behavioral change of volunteers before or after their participation in the projects. Our results show that many NCCS projects have enhanced the learning of participants in different areas (e.g. increasing knowledge about species and reco
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14

Soria Aguirre, Johanna Maribel, Olivér Váczi, Marianna Biró, et al. "Citizen Science for Nature Conservation in Hungary A Three-Dimensional Approach." Citizen Science: Theory and Practice 9, no. 1 (2024): 39. http://dx.doi.org/10.5334/cstp.762.

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Nature conservation–related citizen science (NCCS) has grown rapidly worldwide in previous years. In Hungary, a few citizen science (CS) projects have been operating for years and some have only recently launched. Our aim herein is to assess the performance of eight Hungarian NCCS projects in three dimensions: a) science, b) nature conservation, and c) participants’ development. An evaluation framework was developed for the assessment. Our results show that the Common Bird Monitoring Program performed the best overall. This is also the oldest NCCS project in the country. When comparing the per
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15

Thomason, James, Andrew Carlin, and Liu Yang. "Non-Circular Cross-Section Fibres for Composite Reinforcement—A Review with a Focus on Flat Glass Fibres." Fibers 12, no. 11 (2024): 98. http://dx.doi.org/10.3390/fib12110098.

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Glass fibre reinforcements form the backbone of the composites industry. Today, glass fibre products account for more than 95% of the fibre reinforcements used in the composites industry. Since the first commercialisation of glass fibres for composite reinforcement in the 1930s, the cross-sectional shape of glass fibres has remained exclusively circular. However, many of the other types of fibre reinforcement have a non-circular cross section (NCCS). This paper reviews the available knowledge on the production of NCCS glass fibres and some of the possibilities that such fibres offer to enhance
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16

Akbar, Dimas Abdillah, Kusmono, Muhammad Waziz Wildan, and Mochammad Noer Ilman. "Extraction and Characterization of Nanocrystalline Cellulose (NCC) from Ramie Fiber by Hydrochloric Acid Hydrolysis." Key Engineering Materials 867 (October 2020): 109–16. http://dx.doi.org/10.4028/www.scientific.net/kem.867.109.

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The present study investigates the structural, crystallinity index, crystallite size, morphological, and the dimension of Nanocrystalline Cellulose (NCC) extracted from ramie fiber by hydrochloric acid-hydrolysis. NCC was chosen because it has high strength and modulus compared to other natural materials. Ramie fiber was chosen because it has high cellulose content and abundant in Indonesia. The other reason is ramie has a high crystallinity index compared to other natural fibers. The extraction process was carried out into two steps: cellulose purification then followed by hydrochloric acid h
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17

Purwandari, Vivi, and Malemta Tarigan. "PREPARASI FILM NANOKOMPOSIT POLIVINIL ALKOHOL (PVA)/NANOKARBON DARI CANGKANG BUAH SAWIT (NCCS) DENGAN METODE PENCAMPURAN LARUTAN." JURNAL KIMIA SAINTEK DAN PENDIDIKAN 6, no. 1 (2022): 11–16. http://dx.doi.org/10.51544/kimia.v6i1.2977.

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Polyvinyl alcohol (PVA) has good compatibility when added as filler in the form of nanocarbon so that it can produce environmentally friendly nanocomposite products. Thus, the addition of nanocomposites to PVA-based films is expected to increase and improve the mechanical properties of the resulting PVA films. This study aims to utilize palm fruit shells as raw materials for nanocarbons and as fillers for nanocomposites, as well as to determine the mechanical properties and thermal strength of nanocarbon nanofibers in the PVA matrix. Composite films were made using the solution mixing method.
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18

Ritonga, Sally Irvina, Erna Frida, and Syahrul Humaidi. "Extraction and Characterization of Nanocrystalline Cellulose from Sugar Palm Fibres (Arenga Pinnata)." Prisma Sains : Jurnal Pengkajian Ilmu dan Pembelajaran Matematika dan IPA IKIP Mataram 11, no. 2 (2023): 612. http://dx.doi.org/10.33394/j-ps.v11i2.7935.

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In this work, cellulose was isolated from sugar palm fibre (Arenga pinnata) and converted into sugar palm fibre nanocrystalline cellulose (NCCs) in the hamlet of Medan Sinembah, Indonesia. Alkalization and bleaching were the stages of the therapy process. The cellulose removed with 30 weight percent concentrated sulfuric acid was then used to isolate NCC. Using Fourier transform infrared spectroscopy (FT-IR), the chemical make-up of sugar palm fibre and NCCs was identified. On the basis of structural analysis, X-ray diffraction (XRD) was used. Scanning electron microscopy (SEM) was used for mo
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19

Abdalla Bakheit, Ahmed, Daud Baraka Abdallah, Elnazeer I. Hamedelniel, Zuhair A. Osman, and Khaled M. Algaobahi. "Characterization and Evaluation of Carboxymethyl Starch of Cajanus Cajan Seeds as Tablet Binder." Oriental Journal of Physical Sciences 2, no. 1 (2017): 21–28. http://dx.doi.org/10.13005/ojps02.01.04.

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The aim of this study was to characterize carboxymethyl cajanus cajan starch (CMCCS) and evaluate its capacity as binder, using metronidazole as model drug. Wet granulation method was adopted in preparation of metronidazole tablets containing CMCCS. Native cajanus cajan starch (NCCS) was carboxymethylated using monochloroacetic acid (MCA) and sodium hydroxide. Also the effect of CMCCS concentration and wet massing time on the physical properties of metronidazole (200 mg) tablet formulations was tested in a 22 full factorial design. The degree of substitution, amylose content, moisture content,
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20

Ye, Jun, Zhenhan Zhang, Rui Yong, and Shigui Du. "MAGDM Model Using the Exponential Similarity Measure of Neutrosophic Confidence Cubic Sets in a Single-Valued Neutrosophic Multivalued Circumstance." Journal of Mathematics 2023 (April 4, 2023): 1–12. http://dx.doi.org/10.1155/2023/5150472.

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Probability estimation of small sample data is a key tool to ensure the probability that sample data fall within the confidence interval at a certain confidence level and probability distribution, which shows its advantages in practical engineering applications. Then, regarding a group decision-making (GDM) problem in the situation of indeterminacy and inconsistency, several experts/decision makers will assign several true, false, and indeterminate fuzzy values to the evaluation values of each alternative over different attributes, and then form a single-valued neutrosophic multivalued set (Sv
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Sternberg, J., and S. J. Kimber. "The relationship between emerging neural crest cells and basement membranes in the trunk of the mouse embryo: a TEM and immunocytochemical study." Development 98, no. 1 (1986): 251–68. http://dx.doi.org/10.1242/dev.98.1.251.

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The earliest stage of neural crest cell (NCC) migration is characterized by an epitheliomesenchymal transformation, as the cells leave the neural tube. There is evidence that in a number of cell systems this transformation is accompanied by alteration or depletion of associated basement membranes. This study examines the ultrastructural relationship between mouse NCCs and adjacent basement membranes during the earliest stages of migration from the neural tube. Basement membranes were identified by transmission electron microscopy (TEM) and immunofluorescence using antibodies to type-IV collage
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22

Ratna, S. Aprilia, N. Arahman, and A. A. Munawar. "Characterization of cellulose nanocrystalline isolated from banana peduncles using acid hydrolysis." IOP Conference Series: Earth and Environmental Science 922, no. 1 (2021): 012072. http://dx.doi.org/10.1088/1755-1315/922/1/012072.

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Abstract The study aimed to characterize cellulose nanocrystalline (NCCs) from banana peduncles using acid hydrolysis. The NCCs isolation process was done by hydrolysis using H2SO4 with concentrations of 1M, 2M, and 3M at a microwave power of 100 Watts within 1 hour of hydrolysis. The product of NCCs was characterized in term of yield, chemical composition (by FTIR), and its crystallinity. The result showed that the highest yield of 88.33% was obtained in acid hydrolysis at the concentration of 1M H2SO4. The results of the FTIR test showed that non-cellulose content had been removed and demons
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23

Erhardt, Shannon, Mingjie Zheng, Xiaolei Zhao, Tram P. Le, Tina O. Findley, and Jun Wang. "The Cardiac Neural Crest Cells in Heart Development and Congenital Heart Defects." Journal of Cardiovascular Development and Disease 8, no. 8 (2021): 89. http://dx.doi.org/10.3390/jcdd8080089.

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The neural crest (NC) is a multipotent and temporarily migratory cell population stemming from the dorsal neural tube during vertebrate embryogenesis. Cardiac neural crest cells (NCCs), a specified subpopulation of the NC, are vital for normal cardiovascular development, as they significantly contribute to the pharyngeal arch arteries, the developing cardiac outflow tract (OFT), cardiac valves, and interventricular septum. Various signaling pathways are shown to orchestrate the proper migration, compaction, and differentiation of cardiac NCCs during cardiovascular development. Any loss or dysr
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Strachan, Lauren R., and Maureen L. Condic. "Cranial neural crest recycle surface integrins in a substratum-dependent manner to promote rapid motility." Journal of Cell Biology 167, no. 3 (2004): 545–54. http://dx.doi.org/10.1083/jcb.200405024.

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Cell migration is essential for proper development of numerous structures derived from embryonic neural crest cells (NCCs). Although the migratory pathways of NCCs have been determined, the molecular mechanisms regulating NCC motility remain unclear. NCC migration is integrin dependent, and recent work has shown that surface expression levels of particular integrin α subunits are important determinants of NCC motility in vitro. Here, we provide evidence that rapid cranial NCC motility on laminin requires integrin recycling. NCCs showed both ligand- and receptor-specific integrin regulation in
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Chaiyalap, Somchet, Ritthikrai Chai-ngam, Juthaporn Saengprajak, Jenjira Piamdee, Apipong Putkham, and Arnusorn Saengprajak. "Effect of the non-uniform combustion core shape on the biochar production characteristics of the household biomass gasifier stove." International Journal of Renewable Energy Development 12, no. 6 (2023): 1018–29. http://dx.doi.org/10.14710/ijred.2023.56575.

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The global demand for biochar in agricultural and carbon sequestration applications is increasing; nevertheless, biochar production using the 50-liter household biomass gasifier stove (50L-HBGS) in Thailand found major issues that need to be improved. The objective of this study was to study the effects of the airflow in the non-uniform combustion core shape (NCCS) on the biochar production characteristic of the 50L-HBGS. The new design of the NCCS was constructed and studied to replace the existing combustion core shape (ECCS) at Mahasarakham University. The height, air inlet, and air outlet
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Chatzi, Despoina, Stella Aikaterini Kyriakoudi, Iasonas Dermitzakis, Maria Eleni Manthou, Soultana Meditskou, and Paschalis Theotokis. "Clinical and Genetic Correlation in Neurocristopathies: Bridging a Precision Medicine Gap." Journal of Clinical Medicine 13, no. 8 (2024): 2223. http://dx.doi.org/10.3390/jcm13082223.

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Neurocristopathies (NCPs) encompass a spectrum of disorders arising from issues during the formation and migration of neural crest cells (NCCs). NCCs undergo epithelial–mesenchymal transition (EMT) and upon key developmental gene deregulation, fetuses and neonates are prone to exhibit diverse manifestations depending on the affected area. These conditions are generally rare and often have a genetic basis, with many following Mendelian inheritance patterns, thus making them perfect candidates for precision medicine. Examples include cranial NCPs, like Goldenhar syndrome and Axenfeld–Rieger synd
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27

Đuknić, Miloš, Nela Puškaš, Milica Labudović-Borović, and Radmila Janković. "Origin of enteric nervous system cells and migration pathways during embryonic development." Zdravstvena zastita 51, no. 2 (2022): 20–35. http://dx.doi.org/10.5937/zdravzast51-37799.

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The enteric nervous system (ENS) is represented by a complex network of neurons, glial and other cells within the wall of the digestive tract. ENS is responsible for numerous, vital functions in our body. Thus, ENS regulates motility of the digestive tract, secretion into the intestinal lumen, exchange of fluid and electrolytes through the mucosa, as well as mucosal perfusion. In order to perform these important functions, proper embryonic development of ENS is necessary. ENS cells are derived from precursor cells of the neural crest (NCCs - neural crest cells). Two cell populations that contr
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Mohamed, Abdel-Baset, Mostafa Hashem, and Hichem Eleuch. "Enhancing the Generated Stable Correlation in a Dissipative System of Two Coupled Qubits inside a Coherent Cavity via Their Dipole-Dipole Interplay." Entropy 21, no. 7 (2019): 672. http://dx.doi.org/10.3390/e21070672.

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We explore the dissipative dynamics of two coupled qubits placed inside a coherent cavity-field under dipole-dipole interplay and 2-photon transitions. The generated non-classical correlations (NCCs) beyond entanglement are investigated via two measures based on the Hilbert-Schmidt norm. It is found that the robustness of the generated NCCs can be greatly enhanced by performing the intrinsic dissipation rate, dipole-dipole interplay rate, initial coherence intensity and the degree of the coherent state superpositions. The results show that the intrinsic decoherence stabilize the stationarity o
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29

Qvarnström, Ulla. "Nordic College of Caring Sciences (NCCS)." Scandinavian Journal of Caring Sciences 3, no. 2 (1989): 51–52. http://dx.doi.org/10.1111/j.1471-6712.1989.tb00372.x.

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30

Cohen, Malkiel A., Katherine J. Wert, Johanna Goldmann, et al. "Human neural crest cells contribute to coat pigmentation in interspecies chimeras after in utero injection into mouse embryos." Proceedings of the National Academy of Sciences 113, no. 6 (2016): 1570–75. http://dx.doi.org/10.1073/pnas.1525518113.

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The neural crest (NC) represents multipotent cells that arise at the interphase between ectoderm and prospective epidermis of the neurulating embryo. The NC has major clinical relevance because it is involved in both inherited and acquired developmental abnormalities. The aim of this study was to establish an experimental platform that would allow for the integration of human NC cells (hNCCs) into the gastrulating mouse embryo. NCCs were derived from pluripotent mouse, rat, and human cells and microinjected into embryonic-day-8.5 embryos. To facilitate integration of the NCCs, we used recipien
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31

Solano-Reynoso, Aydeé M., Ruth Fany Quispe-Quispe, Yudith Choque-Quispe, et al. "Activated Nanocellulose from Corn Husk: Application to As and Pb Adsorption Kinetics in Batch Wastewater." Polymers 16, no. 24 (2024): 3515. https://doi.org/10.3390/polym16243515.

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The aim of this study was to evaluate the removal of Pb and As from an aqueous solution using corn residue cellulose nanocrystals (NCCs). The corn husk was subjected to alkaline digestion, followed by bleaching and esterification with 3% citric acid to obtain NCCs. A 10 ppm multimetal solution of Pb and As was prepared. The adsorption process was evaluated by adjusting the pH and NCC dosage, optimized through the nonlinear regression of empirical mathematical models. Based on the optimal parameters, the kinetics were evaluated using the PFO and PSO models. The NCCs displayed nanometer-level ch
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Inubushi, Toshihiro, Yuichiro Nakanishi, Makoto Abe, et al. "The cell surface hyaluronidase TMEM2 plays an essential role in mouse neural crest cell development and survival." PLOS Genetics 18, no. 7 (2022): e1009765. http://dx.doi.org/10.1371/journal.pgen.1009765.

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Hyaluronan (HA) is a major extracellular matrix component whose tissue levels are dynamically regulated during embryonic development. Although the synthesis of HA has been shown to exert a substantial influence on embryonic morphogenesis, the functional importance of the catabolic aspect of HA turnover is poorly understood. Here, we demonstrate that the transmembrane hyaluronidase TMEM2 plays an essential role in neural crest development and the morphogenesis of neural crest derivatives, as evidenced by the presence of severe craniofacial abnormalities in Wnt1-Cre–mediated Tmem2 knockout (Tmem
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Wang, Wei, Jian Li, and Jun Hu. "Triaxial Mechanical Properties and Micromechanism of Calcareous Sand Modified by Nanoclay and Cement." Geofluids 2021 (February 6, 2021): 1–9. http://dx.doi.org/10.1155/2021/6639602.

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Calcareous sand is developed by the fracture of marine biological skeleton under the impact of seawater. Calcareous sand is not transported in the process of deposition. Therefore, calcareous sand retains the characteristics of marine biological skeleton, low strength, and porous. In order to study the effect of nanoclay and cement on the modification of calcareous sand, a series of tests were carried out on the modified cement calcareous sand (CCS) with different content of nanoclay. In this study, the triaxial mechanical properties and failure modes of nanoclay and cement composite modified
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Bi-Lin, Kathleen Wung, Pratap Veerabrahma Seshachalam, Tran Tuoc, Anastassia Stoykova, Sujoy Ghosh, and Manvendra K. Singh. "Critical role of the BAF chromatin remodeling complex during murine neural crest development." PLOS Genetics 17, no. 3 (2021): e1009446. http://dx.doi.org/10.1371/journal.pgen.1009446.

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The BAF complex plays an important role in the development of a wide range of tissues by modulating gene expression programs at the chromatin level. However, its role in neural crest development has remained unclear. To determine the role of the BAF complex, we deleted BAF155/BAF170, the core subunits required for the assembly, stability, and functions of the BAF complex in neural crest cells (NCCs). Neural crest-specific deletion ofBAF155/BAF170leads to embryonic lethality due to a wide range of developmental defects including craniofacial, pharyngeal arch artery, and OFT defects. RNAseq and
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Wiszniak, Sophie, Francesca E. Mackenzie, Peter Anderson, Samuela Kabbara, Christiana Ruhrberg, and Quenten Schwarz. "Neural crest cell-derived VEGF promotes embryonic jaw extension." Proceedings of the National Academy of Sciences 112, no. 19 (2015): 6086–91. http://dx.doi.org/10.1073/pnas.1419368112.

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Jaw morphogenesis depends on the growth of Meckel’s cartilage during embryogenesis. However, the cell types and signals that promote chondrocyte proliferation for Meckel’s cartilage growth are poorly defined. Here we show that neural crest cells (NCCs) and their derivatives provide an essential source of the vascular endothelial growth factor (VEGF) to enhance jaw vascularization and stabilize the major mandibular artery. We further show in two independent mouse models that blood vessels promote Meckel’s cartilage extension. Coculture experiments of arterial tissue with NCCs or chondrocytes de
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Zitcer, Andrew, and Richardson Dilworth. "Grocery Cooperatives as Governing Institutions in Neighborhood Commercial Corridors." Urban Affairs Review 55, no. 2 (2017): 558–90. http://dx.doi.org/10.1177/1078087417709999.

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We explore cooperatives’ potential to play governing roles in neighborhood commercial corridors (NCCs) by examining one grocery cooperative in Philadelphia that has had stores on three NCCs in the city. We distinguish between an anchor institution role, where one organization provides collective goods for the corridor, and governance, where multiple corridor stakeholders collectively provide goods. We conclude that a cooperative will more likely play a governance role if it enters an NCC at a point when there are no other potential corridor-governing organizations, and when the NCC itself is a
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Yeo, Eugenia Li Ling, Enya Ong, Boon Hao Hong, et al. "Effect of tumor-immune microenvironment (TIME) on disparate ascending (A) and descending (D) subtypes of nasopharyngeal carcinoma (NPC)." Journal of Clinical Oncology 42, no. 23_suppl (2024): 145. http://dx.doi.org/10.1200/jco.2024.42.23_suppl.145.

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145 Background: Endemic NPC is invariably linked to Epstein-Barr virus infection, and often presents as locoregionally-advanced (LA-) disease. Nonetheless, it is acknowledged that LA-NPC is clinically heterogeneous, with disparate clinical presentations of ascending (A) and descending (D) subtypes that are characterized by T3-4N0-1 and T1-2N2-3 disease, respectively. Here, we investigated the TIME between these distinct NPC phenotypes using whole transcriptome sequencing and digital pathology. Methods: We utilized a cohort of 111 patients with NPC from 2 institutions – NCCS (n=68) and JXCH (n=
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Etchevers, H. C., C. Vincent, N. M. Le Douarin, and G. F. Couly. "The cephalic neural crest provides pericytes and smooth muscle cells to all blood vessels of the face and forebrain." Development 128, no. 7 (2001): 1059–68. http://dx.doi.org/10.1242/dev.128.7.1059.

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Most connective tissues in the head develop from neural crest cells (NCCs), an embryonic cell population present only in vertebrates. We show that NCC-derived pericytes and smooth muscle cells are distributed in a sharply circumscribed sector of the vasculature of the avian embryo. As NCCs detach from the neural folds that correspond to the future posterior diencephalon, mesencephalon and rhombencephalon, they migrate between the ectoderm and the neuroepithelium into the anterior/ventral head, encountering mesoderm-derived endothelial precursors. Together, these two cell populations build a va
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Iskander, Samir M., Meghan M. Feeney, Kirby Yee та Norman D. Rosenblum. "Protein Kinase 2β Is Expressed in Neural Crest-Derived Urinary Pacemaker Cells and Required for Pyeloureteric Contraction". Journal of the American Society of Nephrology 29, № 4 (2018): 1198–209. http://dx.doi.org/10.1681/asn.2017090951.

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Nonobstructive hydronephrosis, defined as dilatation of the renal pelvis with or without dilatation of the ureter, is the most common antenatal abnormality detected by fetal ultrasound. Yet, the etiology of nonobstructive hydronephrosis is poorly defined. We previously demonstrated that defective development of urinary tract pacemaker cells (utPMCs) expressing hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) and the stem cell marker cKIT causes abnormal ureteric peristalsis and nonobstructive hydronephrosis. However, further investigation of utPMC development and function i
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Vincentz, Joshua W., David E. Clouthier, and Anthony B. Firulli. "Mis-Expression of a Cranial Neural Crest Cell-Specific Gene Program in Cardiac Neural Crest Cells Modulates HAND Factor Expression, Causing Cardiac Outflow Tract Phenotypes." Journal of Cardiovascular Development and Disease 7, no. 2 (2020): 13. http://dx.doi.org/10.3390/jcdd7020013.

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Congenital heart defects (CHDs) occur with such a frequency that they constitute a significant cause of morbidity and mortality in both children and adults. A significant portion of CHDs can be attributed to aberrant development of the cardiac outflow tract (OFT), and of one of its cellular progenitors known as the cardiac neural crest cells (NCCs). The gene regulatory networks that identify cardiac NCCs as a distinct NCC population are not completely understood. Heart and neural crest derivatives (HAND) bHLH transcription factors play essential roles in NCC morphogenesis. The Hand1PA/OFT enha
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Bielefeld, Wolfgang. "Metropolitan Nonprofit Sectors: Findings from NCCS Data." Nonprofit and Voluntary Sector Quarterly 29, no. 2 (2000): 297–314. http://dx.doi.org/10.1177/0899764000292005.

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Steele, Julie A. "Slow and Deliberate: NCCS Moves Into 1992." JNCI: Journal of the National Cancer Institute 84, no. 1 (1992): 15–16. http://dx.doi.org/10.1093/jnci/84.1.15.

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Martínez-Morales, Patricia L., Ruth Diez del Corral, Isabel Olivera-Martínez, et al. "FGF and retinoic acid activity gradients control the timing of neural crest cell emigration in the trunk." Journal of Cell Biology 194, no. 3 (2011): 489–503. http://dx.doi.org/10.1083/jcb.201011077.

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Coordination between functionally related adjacent tissues is essential during development. For example, formation of trunk neural crest cells (NCCs) is highly influenced by the adjacent mesoderm, but the molecular mechanism involved is not well understood. As part of this mechanism, fibroblast growth factor (FGF) and retinoic acid (RA) mesodermal gradients control the onset of neurogenesis in the extending neural tube. In this paper, using gain- and loss-of-function experiments, we show that caudal FGF signaling prevents premature specification of NCCs and, consequently, premature epithelial–
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Dolde, Xenia, Christiaan Karreman, Marianne Wiechers, Stefan Schildknecht, and Marcel Leist. "Profiling of Human Neural Crest Chemoattractant Activity as a Replacement of Fetal Bovine Serum for In Vitro Chemotaxis Assays." International Journal of Molecular Sciences 22, no. 18 (2021): 10079. http://dx.doi.org/10.3390/ijms221810079.

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Fetal bovine serum (FBS) is the only known stimulus for the migration of human neural crest cells (NCCs). Non-animal chemoattractants are desirable for the optimization of chemotaxis as-says to be incorporated in a test battery for reproductive and developmental toxicity. We con-firmed here in an optimized transwell assay that FBS triggers directed migration along a con-centration gradient. The responsible factor was found to be a protein in the 30–100 kDa size range. In a targeted approach, we tested a large panel of serum constituents known to be chem-otactic for NCCs in animal models (e.g.,
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Johnson, Sarah, Juyu Chueh, Matthew J. Gounis, et al. "Mechanical behavior of in vitro blood clots and the implications for acute ischemic stroke treatment." Journal of NeuroInterventional Surgery 12, no. 9 (2019): 853–57. http://dx.doi.org/10.1136/neurintsurg-2019-015489.

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BackgroundClot mechanical properties are influenced by composition and the arrangement of components within the clot. This work investigates the effects of platelet-driven contraction on blood clot microstructure and mechanical behavior, and provides insight into some implications for mechanical thrombectomy.MethodsPlatelet-contracted clot analogues (PCCs) and non-contracted clot analogues (NCCs) were prepared from blood mixtures of various hematocrits (%H), that is, the volume percentage of red blood cells (RBCs) in the mixture. Mechanical testing was performed to compare the behavior of the
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Yahya, Imadeldin, Marion Böing, Beate Brand-Saberi, and Gabriela Morosan-Puopolo. "How to distinguish between different cell lineages sharing common markers using combinations of double in-situ-hybridization and immunostaining in avian embryos: CXCR4-positive mesodermal and neural crest-derived cells." Histochemistry and Cell Biology 155, no. 1 (2020): 145–55. http://dx.doi.org/10.1007/s00418-020-01920-7.

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AbstractCell migration plays a crucial role in early embryonic development. The chemokine receptor CXCR4 has been reported to guide migration of neural crest cells (NCCs) to form the dorsal root ganglia (DRG) and sympathetic ganglia (SG). CXCR4 also plays an important part during the formation of limb and cloacal muscles. NCCs migration and muscle formation during embryonic development are usually considered separately, although both cell lineages migrate in close neighbourhood and have markers in common. In this study, we present a new method for the simultaneous detection of CXCR4, mesoderma
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Morikawa, Satoru, Takehito Ouchi, Shinsuke Shibata, et al. "Applications of Mesenchymal Stem Cells and Neural Crest Cells in Craniofacial Skeletal Research." Stem Cells International 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/2849879.

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Craniofacial skeletal tissues are composed of tooth and bone, together with nerves and blood vessels. This composite material is mainly derived from neural crest cells (NCCs). The neural crest is transient embryonic tissue present during neural tube formation whose cells have high potential for migration and differentiation. Thus, NCCs are promising candidates for craniofacial tissue regeneration; however, the clinical application of NCCs is hindered by their limited accessibility. In contrast, mesenchymal stem cells (MSCs) are easily accessible in adults, have similar potential for self-renew
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Ong, Ashley. "Treatment Planning Optimization in Proton Therapy – NCCS experience." Journal of Medical Imaging and Radiation Sciences 53, no. 3 (2022): 5. http://dx.doi.org/10.1016/j.jmir.2022.03.096.

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Ma, Xiaoqiang, Gökalp Gözaydın, Huiying Yang, et al. "Upcycling chitin-containing waste into organonitrogen chemicals via an integrated process." Proceedings of the National Academy of Sciences 117, no. 14 (2020): 7719–28. http://dx.doi.org/10.1073/pnas.1919862117.

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Chitin is the most abundant renewable nitrogenous material on earth and is accessible to humans in the form of crustacean shell waste. Such waste has been severely underutilized, resulting in both resource wastage and disposal issues. Upcycling chitin-containing waste into value-added products is an attractive solution. However, the direct conversion of crustacean shell waste-derived chitin into a wide spectrum of nitrogen-containing chemicals (NCCs) is challenging via conventional catalytic processes. To address this challenge, in this study, we developed an integrated biorefinery process to
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Chijimatsu, Ryota, Makoto Ikeya, Yukihiko Yasui, et al. "Characterization of Mesenchymal Stem Cell-Like Cells Derived From Human iPSCs via Neural Crest Development and Their Application for Osteochondral Repair." Stem Cells International 2017 (2017): 1–18. http://dx.doi.org/10.1155/2017/1960965.

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Mesenchymal stem cells (MSCs) derived from induced pluripotent stem cells (iPSCs) are a promising cell source for the repair of skeletal disorders. Recently, neural crest cells (NCCs) were reported to be effective for inducing mesenchymal progenitors, which have potential to differentiate into osteochondral lineages. Our aim was to investigate the feasibility of MSC-like cells originated from iPSCs via NCCs for osteochondral repair. Initially, MSC-like cells derived from iPSC-NCCs (iNCCs) were generated and characterized in vitro. These iNCC-derived MSC-like cells (iNCMSCs) exhibited a homogen
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