Journal articles: 'NDB'

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Howitt, Crispin A., Pacer K. Udall, and Wim F. J. Vermaas. "Type 2 NADH Dehydrogenases in the CyanobacteriumSynechocystis sp. Strain PCC 6803 Are Involved in Regulation Rather Than Respiration." Journal of Bacteriology 181, no. 13 (July 1, 1999): 3994–4003. http://dx.doi.org/10.1128/jb.181.13.3994-4003.1999.

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ABSTRACT Analysis of the genome of Synechocystis sp. strain PCC 6803 reveals three open reading frames (slr0851,slr1743, and sll1484) that may code for type 2 NAD(P)H dehydrogenases (NDH-2). The sequence similarity between the translated open reading frames and NDH-2s from other organisms is low, generally not exceeding 30% identity. However, NAD(P)H and flavin adenine dinucleotide binding motifs are conserved in all three putative NDH-2s in Synechocystis sp. strain PCC 6803. The three open reading frames were cloned, and deletion constructs were made for each. An expression construct containing one of the three open reading frames, slr1743, was able to functionally complement anEscherichia coli mutant lacking both NDH-1s and NDH-2s. Therefore, slr0851, slr1743, andsll1484 have been designated ndbA,ndbB, and ndbC, respectively. Strains that lacked one or more of the ndb genes were created in wild-type and photosystem (PS) I-less backgrounds. Deletion ofndb genes led to small changes in photoautotrophic growth rates and respiratory activities. Electron transfer rates into the plastoquinone pool in thylakoids in darkness were consistent with the presence of a small amount of NDH-2 activity in thylakoids. No difference was observed between wild-type and the Ndb-less strains in the banding patterns seen on native gels when stained for either NADH or NADPH dehydrogenase activity, indicating that the Ndb proteins do not accumulate to high levels. A striking phenotype of the PS I-less background strains lacking one or more of the NDH-2s is that they were able to grow at high light intensities that were lethal to the control strain but they retained normal PS II activity. We suggest that the Ndb proteins in Synechocystis sp. strain PCC 6803 are redox sensors and that they play a regulatory role responding to the redox state of the plastoquinone pool.

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Ribeiro, Jackson, and Gilberto Maringoni. "O banco e o arranjo de reserva dos BRICS em perspectiva." Brazilian Journal of International Relations 8, no. 2 (September 9, 2019): 406–26. http://dx.doi.org/10.36311/2237-7743.2019.v8n2.09.p406.

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Este artigo tem como objetivo analisar os documentos da cúpula dos BRICS de Fortaleza, ocorrida em julho de 2014 que criou duas instituições financeiras, o Novo Banco de Desenvolvimento - NBD - e o Arranjo Contingencial de Reservas - ACR. São iniciativas importantes para estreitar os laços do grupo que reúne Brasil, Rússia, Índia, China e África do Sul, além de servirem para alargar a ordem monetária e financeira internacional. O NBD e o ACR são complementares às instituições multilaterais tradicionais de Bretton Woods: Banco Mundial e FMI. Complementares, pois foi adotada uma orientação cautelosa na criação desses arranjos protagonizados pelos BRICS. Tais arranjos alternativos incorporaram muitas prerrogativas e princípios do Banco Mundial e FMI, como a necessidade de acordo de cada país membro para acessar parte relevante de recursos no ACR. Mesmo incorporando prerrogativas e os princípios dominantes nessas organizações tradicionais NBD e ACR criam ambientes institucionais com potencial para possibilitar novos desdobramentos. Abstract: This article aims to analyse the documents of the BRICS Fortaleza summit held in July 2014 that created two financial institutions, the New Development Bank – NDB and the Contingent Reserve Arrangement – CRA. They are important initiatives to strengthen the ties of the group that includes Brazil, Russia, India, China and South Africa, as well as serve to broaden the international monetary and financial order. NDB and CRA are complementary to traditional multilateral Bretton Woods institutions: the World Bank and the IMF. Complementary, because a cautious orientation was adopted in the creation of these BRICS arrangements. Such alternative arrangements have incorporated many prerogatives and principles of the World Bank and IMF, such as the need for each member country to agree to access a relevant part of the resources in the CRA. Even incorporating prerogatives and the dominant principles in these traditional NDB and CRA organisations create institutional environments with the potential to enable further unfoldings. Keywords: BRICS; NDB; ACR; ECONOMIC GOVERNANCE. Recebido em: fevereiro/2019. Aprovado em: setembro/2019.

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Kubo, Shinichiro, Tatsuya Noda, Tomoya Myojin, Yuichi Nishioka, Saho Kanno, Tsuneyuki Higashino, Masatoshi Nishimoto, et al. "Tracing all patients who received insured dialysis treatment in Japan and the present situation of their number of deaths." Clinical and Experimental Nephrology 26, no. 4 (January 1, 2022): 360–67. http://dx.doi.org/10.1007/s10157-021-02163-z.

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Abstract Background The survival rate of chronic dialysis patients in Japan remains the highest worldwide, so there is value in presenting Japan’s situation internationally. We examined whether aggregate figures on dialysis patients in the National Database of Health Insurance Claims and Special Health Checkups of Japan (NDB), which contains data on insured procedures of approximately 100 million Japanese residents, complement corresponding figures in the Japanese Society for Dialysis Therapy Renal Data Registry (JRDR). Methods Subjects were patients with medical fee points for dialysis recorded in the NDB during 2014–2018. We analyzed annual numbers of dialysis cases, newly initiated dialysis cases– and deaths. Results Compared with the JRDR, the NDB had about 6–7% fewer dialysis cases but a similar number of newly initiated dialysis cases. In the NDB, the number of deaths was about 6–10% lower, and the number of hemodialysis cases was lower, while that of peritoneal dialysis cases was higher. The cumulative survival rate at dialysis initiation was approximately 6 percentage points lower in the NDB than in the JRDR, indicating that some patients die at dialysis initiation. Cumulative survival rate by age group was roughly the same between the NDB and JRDR in both sexes. Conclusion The use of the NDB enabled us to aggregate data of dialysis patients. With the definition of dialysis patients used in this study, analyses of concomitant medications, comorbidities, surgeries, and therapies will become possible, which will be useful in many future studies.

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Alifu, Xiafukaiti, Peng Ziqi, and Tatsuo Shiina. "Lidar transmitter offers “non-diffracting” property through short distance in highly-dense random media." EPJ Web of Conferences 176 (2018): 08019. http://dx.doi.org/10.1051/epjconf/201817608019.

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Non-diffracting beam (NDB) is useful in lidar transmitter because of its high propagation efficiency and high resolution. We aimed to generate NDB in random media such as haze and cloud. The laboratory experiment was conducted with diluted processed milk (fat: 1.8%, 1.1μmφ). Narrow view angle detector of 5.5mrad was used to detect the forward scattering waveform. We obtained the central peak of NDB at the propagation distance of 5cm ~ 30cm in random media by adjusting the concentration of <10%.

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Purbo Wartoyo, Bayu, Gatot Kuswara, M. Roby Syaritno, and Ucok Sinaga. "Rancang Bangun Remote-Control Monitoring System (RCMS) pada peralatan Navigasi Udara NDB di Makassar Air Traffic Service Center berbasis Internet of Thing (IoT)." Airman: Jurnal Teknik dan Keselamatan Transportasi 3, no. 2 (December 31, 2020): 171–80. http://dx.doi.org/10.46509/ajtk.v3i2.20.

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“Rancang Bangun Remote Control Monitoring System (RCMS) pada peralatan Navigasi Udara NDB di Cluster Cabang Makassar (MATSC) Berbasis Internet of Thing (IoT)”. Manfaat RCMS diantaranya yaitu; Dapat membantu teknisi pelaksana pemeliharaan dalam pelaksanaan tugas pemeliharaan level pada tertentu, Sebagai wujud sinergi dan kolaborasi dunia industri penerbangan dengan pendidikan vokasi, Dengan adanya RCMS ini maka akan diperoleh data yang lebih baik bagi penelitian lebih lanjut. Tujuaan perancangan ini yaitu ; Merancang sebuah Remote Control and Monitoring System (RCMS) untuk NDB Hanjin KMW 250 RB, Mengimplementasikan keilmuan dan teknologi sebagai wujud Kolaborasi dunia pendidikan dengan industri penerbangan, Menyediakan data pemeliharaan peralatan untuk keperluan maintenance management. Dan di control langsung di ruang teknisi untuk mempermudah memonitoring Peralatan Navigasi NDB. Metode perancangan ini berbasis Internet of Thing (IOT). Hasil rancangan ini mampu memberikan tampilan mengenai parameter pada peralatan Navigasi Udara (NDB) di Cabang Makassar (MATSC).

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Giwa, Fiyinfoluwa. "The New Development Bank and Multilateral Trade Facilitation Agreements on BRICS." Management and Economics Research Journal 6 (2020): 1. http://dx.doi.org/10.18639/merj.2020.9900016.

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Brazil, Russia, India, China, and South Africa (BRICS) have made a tremendous economic impact on the world. Through the New Development Bank (NDB) and the Trade Facilitation Agreement (TFA) by the World Trade Organization, they have become stronger. This article made use of different views to discuss the implication of the NDB and TFA on BRICS. No empirical analysis was carried out. From the viewpoints of other scholars, the Trade Ministers of the BRICS and the World Trade Organization, the NDB and TFA can enhance intellectual and economic growth in the BRICS countries.

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Wartoyo, Bayu purbo, Gatot Kuswara, M. Roby Syaritno, and Ucok Sinaga. "Rancang Bangun Remote-Control Monitoring System (RCMS) pada peralatan Navigasi Udara NDB di Makassar Air Traffic Service Center berbasis Internet of Thing (IoT)." Airman: Jurnal Teknik dan Keselamatan Transportasi 3, no. 2 (February 10, 2021): 43–52. http://dx.doi.org/10.46509/ajtkt.v3i2.77.

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Bayu Purbo W, Gatot Kuswara, M Roby Syaritno, Ucok “Rancang Bangun Remote Control Monitoring System (RCMS) pada peralatan Navigasi Udara NDB di Cluster Cabang Makassar (MATSC) Berbasis Internet of Thing (IoT)”. Manfaat RCMS diantaranya yaitu ; Dapat membantu teknisi pelaksana pemeliharaan dalam pelaksanaan tugas pemeliharaan level pada tertentu, Sebagai wujud sinergi dan kolaborasi dunia industri penerbangan dengan pendidikan vokasi, Dengan adanya RCMS ini maka akan diperoleh data yang lebih baik bagi penelitian lebih lanjut. Tujuaan perancangan ini yaitu ; Merancang sebuah Remote Control and Monitoring System (RCMS) untuk NDB Hanjin KMW 250 RB, Mengimplementasikan keilmuan dan teknologi sebagai wujud Kolaborasi dunia pendidikan dengan industri penerbangan, Menyediakan data pemeliharaan peralatan untuk keperluan maintenance management. Dan di control langsung di ruang teknisi untuk mempermudah memonitoring Peralatan Navigasi NDB. Metode perancangan ini berbasis Internet Of Thing (IOT) Hasil rancangan ini mampu memberikan tampilan mengenai parameter pada peralatan Navigasi Udara (NDB) di Cabang Makassar (MATSC)

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Contessoto, Vinícius G., Ryan R. Cheng, Arya Hajitaheri, Esteban Dodero-Rojas, Matheus F. Mello, Erez Lieberman-Aiden, Peter G. Wolynes, Michele Di Pierro, and José N. Onuchic. "The Nucleome Data Bank: web-based resources to simulate and analyze the three-dimensional genome." Nucleic Acids Research 49, no. D1 (October 6, 2020): D172—D182. http://dx.doi.org/10.1093/nar/gkaa818.

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Abstract We introduce the Nucleome Data Bank (NDB), a web-based platform to simulate and analyze the three-dimensional (3D) organization of genomes. The NDB enables physics-based simulation of chromosomal structural dynamics through the MEGABASE + MiChroM computational pipeline. The input of the pipeline consists of epigenetic information sourced from the Encode database; the output consists of the trajectories of chromosomal motions that accurately predict Hi-C and fluorescence insitu hybridization data, as well as multiple observations of chromosomal dynamics in vivo. As an intermediate step, users can also generate chromosomal sub-compartment annotations directly from the same epigenetic input, without the use of any DNA–DNA proximity ligation data. Additionally, the NDB freely hosts both experimental and computational structural genomics data. Besides being able to perform their own genome simulations and download the hosted data, users can also analyze and visualize the same data through custom-designed web-based tools. In particular, the one-dimensional genetic and epigenetic data can be overlaid onto accurate 3D structures of chromosomes, to study the spatial distribution of genetic and epigenetic features. The NDB aims to be a shared resource to biologists, biophysicists and all genome scientists. The NDB is available at https://ndb.rice.edu.

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Stewart, M., and S. E. Fox. "Two populations of rhythmically bursting neurons in rat medial septum are revealed by atropine." Journal of Neurophysiology 61, no. 5 (May 1, 1989): 982–93. http://dx.doi.org/10.1152/jn.1989.61.5.982.

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1. Previous findings, such as the sensitivity of the hippocampal theta rhythm to cholinergic manipulation, support a "pacemaker" role for the cholinergic cells of the medial septal nucleus and the vertical limb of the nucleus of the diagonal band (MSN-NDB). To explore the mechanism(s) of action of systemic antimuscarinic drugs in eliminating the theta rhythm, recordings of hippocampal EEG and rhythmic MSN-NDB neurons that fired in phase with the hippocampal theta rhythm were taken during the administration of atropine in urethane-anesthetized rats. 2. Twenty-two of 33 rhythmic MSN-NDB cells continued to burst at the theta rhythm frequency after administration of a dose of atropine (25 mg/kg iv) that was sufficient to eliminate the theta rhythm (atropine-resistant cells). The remaining 11 cells lost their rhythmic firing pattern over the same time course as the loss of the theta rhythm (atropine-sensitive cells). 3. Both types of rhythmic MSN-NDB cells could be antidromically driven from the fimbria/fornix with similar latencies (range, 0.5-4.0 ms). The extracellularly recorded spike waveforms were not useful in predicting the atropine sensitivity of a given cell. Atropine-resistant cells frequently had higher firing rates than atropine-sensitive cells, but there was sufficient overlap of the two groups to make this a poor predictor of sensitivity. 4. Cooling the fimbria/fornix reversibly eliminated the hippocampal theta rhythm, but had no effect on 21/25 rhythmic MSN-NDB cells tested. This indicates that the atropine-sensitive MSN-NDB cells do not depend on the periodic output from the hippocampus for their rhythmic firing. Recordings from pairs of rhythmic MSN-NDB cells during cooling and/or atropine administration showed unchanged phase relations at the theta rhythm frequency. In rats in which the septohippocampal system was exposed by aspirating the overlying brain tissue, direct application of atropine (10 mg/ml) to the septal nuclei reversibly eliminated the hippocampal theta rhythm. 5. The rhythmic cells of the MSN-NDB are apparently composed of at least two distinct types, both of which potentially contribute to the production of the theta rhythm in the hippocampus. Elimination of hippocampal theta rhythm after local septal atropine application suggests that the loss of rhythmic activity in the group of atropine-sensitive septal cells is sufficient for the elimination of the theta rhythm. A model of the septohippocampal connections necessary for the theta rhythm is presented.

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Pitor, Ján, and Filip Škultéty. "Non Directional Beacons Checking." Transport and Communications 2, no. 2 (2014): 12–16. http://dx.doi.org/10.26552/tac.c.2014.2.3.

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This paper aims to familiarize experts from other fields with issues of flight check of Non Directional Beacon (NDB) and its assessment. The AT-940 Automatic Flight Inspection System and the aircraft PIPER SENECA are described followed by flight check specifications and procedures. Evaluated were the coverage of NDB Z, NDB ZLA located at Žilina airport and Standard Instrument Approach Procedure for runway 06. The results of evaluation are in paragraph 4. The paper is based on project “Centre of excellence for Air Transport” focused on the impact of air transport on environment photogrammetry, surveillance of electromagnetic compatibility of radio navigation aids and radio communication equipment.

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Pamungkas, Mahendra Lantang, Riswanti Dyah Sekar Rahayu, and Trieska Ayu Krisyanti. "Perbandingan Sistem Pinjaman IMF dan BRICS New Development Bank serta Potensi Dominasi Sistem Moneter Internasional." Nation State Journal of International Studies 2, no. 2 (December 31, 2019): 134–50. http://dx.doi.org/10.24076/nsjis.2019v2i2.151.

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America is the dominant power for a long time since the World War and gave many aid for many state developments in the world with their ‘Marshall Plan’ policy. America domination clarified by the existence World Trade Organization. United States of America legitimation not only limited to WTO, there are several international economic organizations such as World Bank and International Monetary Fund where the America hold an important power. Countries that want to compete with America legitimacy establish an organization called BRICS. BRICS consist of Brazil, Russia Federation, India, China, and South Africa. BRICS created a bank called BRICS NDB or National Development bank to compete IMF domination. This research will explain the differentiation between IMF and NDB, alongside with how NDB have capability to compete IMF as an international bank that give loans to countries. This research uses descriptive comparative method, so this research will have focused on comparation between the two banks. Analysis on this research will use Structural Power Theory with Middle Power concept to explain IMF domination and how NDB that created by Middle Powered countries can replace IMF domination.

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Faermann, Renata, Jonathan Weidenfeld, Leonid Chepelev, Wayne Kendal, Raman Verma, Andrew Scott-Moncrieff, Susan Peddle, et al. "Outcomes after Surgery for Early Stage Breast Cancer in Women Staged With Preoperative Breast Magnetic Resonance Imaging According to Breast Tissue Density." Journal of Breast Imaging 1, no. 2 (June 2019): 115–21. http://dx.doi.org/10.1093/jbi/wbz018.

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Abstract Purpose To determine surgical outcomes and breast cancer disease-free survival outcomes of women with early stage breast cancer with and without use of preoperative breast MRI according to breast tissue density. Methods Women with early stage breast cancer diagnosed from 2004 to 2009 were classified into 2 groups: 1) those with dense and heterogeneously dense breasts (DB); 2) those with nondense breasts (NDB) (scattered fibroglandular and fatty replaced tissue). The 2 groups were reviewed to determine who underwent preoperative MRI. Breast tissue density was determined with mammography according to ACR BI-RADS. Patients were compared according to tumor size, grade, stage, and treatment. Survival analysis was performed using Kaplan-Meier estimates. Results In total, 261 patients with mean follow-up of 85 months (25–133) were included: 156 DB and 105 NDB. Disease-free survival outcomes were better in the DB group in patients with MRI than in those without MRI: patients with MRI had significantly fewer local recurrences (P < 0.016) and metachronous contralateral breast cancers (P < 0.001), but this was not the case in the NDB group. Mastectomies were higher in the DB group with preoperative MRI than in those without MRI (P < 0.01), as it was in the NDB group (P > 0.05). Conclusions Preoperative breast MRI was associated with reduced local recurrence and metachronous contralateral cancers in the DB group, but not in the NDB group; however, the DB patients with MRI had higher mastectomy rates.

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Sato, Daisuke, Takeru Shiroiwa, and Takashi Fukuda. "PP079 The Construction Of Database Using Japanese National Claims Database." International Journal of Technology Assessment in Health Care 33, S1 (2017): 108. http://dx.doi.org/10.1017/s0266462317002501.

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INTRODUCTION:In 2014, the Ministry of Health, Labor and Welfare (MHLW) in Japan began to assume a cost-effectiveness perspective. Some expensive pharmaceutical and medical devices have been regulated, which resulted in a drastic change of the healthcare system.The Japanese National Insurance Claims Database (NDB) is an administrative database based on claims data from Medical Insurance Claims since 2008. The government enacted the Act on Assurance of Medical Care for Elderly People during health care reform in 2008. In 2006, the MHLW commenced discussions on a framework for the optimization of the healthcare expenses, which aimed to evaluate the structure of the increase in healthcare expenditure.The NDB was developed as a tool for investigation and analysis by the MHLW in the context of the Healthcare reform. In addition, the NDB was used for the development of academic research in order to contribute to the implementation and evaluation of healthcare policy management.A major strength of the NDB is its exhaustiveness or completeness of insurance claims. The NDB collects data from all insured people nationwide and covers all medical institutions in Japan.METHODS:We applied to the Expert Meeting on Provision of Medical Insurance Claims to examine the research plan, items extracted, and data management. Inpatient and Outpatient information was extracted on medical procedures and payment. Diagnoses for both inpatients and outpatients are coded according to the International Classification of Diseases Tenth Edition (ICD-10). The coding of treatments and surgeries follow Japan's local procedure and surgical coding, which was specifically developed for insurance claims.RESULTS:We generated any personally traceable patient ID from the “hash ID” generated by patient name, sex, date of birth, and insurer number with the aim of protecting personal identifying information in the NDB. The disease of stroke was defined to analyze the database for cost-effectiveness analysis, and to connect disease information to. The prescription claims information described pharmaceutical names, prescription date, total dose, and number of days.CONCLUSIONS:Our study showed the new standard way of analysis for cost-effectiveness analysis using the Japanese National Insurance Claims Database.

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Berman, Helen M., Catherine L. Lawson, and Bohdan Schneider. "Developing Community Resources for Nucleic Acid Structures." Life 12, no. 4 (April 6, 2022): 540. http://dx.doi.org/10.3390/life12040540.

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In this review, we describe the creation of the Nucleic Acid Database (NDB) at Rutgers University and how it became a testbed for the current infrastructure of the RCSB Protein Data Bank. We describe some of the special features of the NDB and how it has been used to enable research. Plans for the next phase as the Nucleic Acid Knowledgebase (NAKB) are summarized.

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Nascimento, Emiliano Nunes do, Marcos Cláudio Pinheiro Rogério, Ana Sancha Malveira Batista, Maria Socorro de Souza Carneiro, Angela Maria de Vasconcelos, Eneas Reis Leite, Aline Vieira Landim, Vandenberg Lira Silva, Joaquim Bezerra Costa, and Hélio Henrique Araújo Costa. "Nutrient intake and quantitative aspects of carcass of finishing sheep fed with diets containing cashew nut meal." Revista Brasileira de Saúde e Produção Animal 13, no. 4 (December 2012): 1099–111. http://dx.doi.org/10.1590/s1519-99402012000400013.

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This work aimed to determine the nutrient intake and quantitative aspects of sheep carcass from three different genetic groups. Eighteen animals with initial average body weight of 20.1kg were used in a completely randomized design, in a factorial 3x2 scheme (three different crossbreeds - 6 F1Dorper x non defined breed, 6 F1Somalis x non defined breed and 6 F1Santa Inês x non defined breed versus two diets). The diets fed to the animals were formulated with or without cashew nuts. The inclusion of cashew nut meal in the diet influenced nutrient intake. Differences of intake among the animal groups were observed as higher intake for F1Dorper x non defined breed (NDB), followed by F1Somalis x NDB and for F1Santa Inês x NDB. However, the control diet produced no difference among these genotypes. The average daily gain was lower for both crossbreeds when cashew nut meal was added in the diets. The evaluated crossbreeds and diets did not affect the feed:gain ratio. The carcasses analyses showed that the inclusion of cashew nut meal in the diets reduced the cold carcass weight and the rib weight. The addition of cashew nut meal in the diets for lambs reduces food intake and carcass yield. The crossbreed F1Dorper x NDB presented the higher rate of average daily gain.

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Hassan, Soha, Mohamed Sultan, Mohamed Sobh, Mohamed S. Elhebiry, Khaled Zahran, Abdelaziz Abdeldayem, Elsayed Issawy, and Samir Kamh. "Crustal Structure of the Nile Delta: Interpretation of Seismic-Constrained Satellite-Based Gravity Data." Remote Sensing 13, no. 10 (May 15, 2021): 1934. http://dx.doi.org/10.3390/rs13101934.

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Interpretations of the tectonic setting of the Nile Delta of Egypt and its offshore extension are challenged by the thick sedimentary cover that conceals the underlying structures and by the paucity of deep seismic data and boreholes. A crustal thickness model, constrained by available seismic and geological data, was constructed for the Nile Delta by inversion of satellite gravity data (GOCO06s), and a two-dimensional (2D) forward density model was generated along the Delta’s entire length. Modelling results reveal the following: (1) the Nile Delta is formed of two distinctive crustal units: the Southern Delta Block (SDB) and the Northern Delta Basin (NDB) separated by a hinge zone, a feature widely reported from passive margin settings; (2) the SDB is characterized by an east–west-trending low-gravity (~−40 mGal) anomaly indicative of continental crust characteristics (depth to Moho (DTM): 36–38 km); (3) the NDB and its offshore extension are characterized by high gravity anomalies (hinge zone: ~10 mGal; Delta shore line: >40 mGal; south Herodotus Basin: ~140 mGal) that are here attributed to crustal thinning and stretching and decrease in DTM, which is ~35 km at the hinge zone, 30–32 km at the shoreline, and 22–20 km south of the Herodotus Basin; and (4) an apparent continuation of the east-northeast–west-southwest transitional crust of the Nile Delta towards the north-northeast–south-southwest-trending Levant margin in the east. These observations together with the reported extensional tectonics along the hinge zone, NDB and its offshore, the low to moderate seismic activity, and the absence of volcanic eruptions in the Nile Delta are all consistent with the NDB being a non-volcanic passive margin transition zone between the North African continental crust (SDB) and the Mediterranean oceanic crust (Herodotus Basin), with the NDB representing a westward extension of the Levant margin extensional transition zone.

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Azuma, Takashi, Takashi Nakano, Ryuji Koizumi, Nobuaki Matsunaga, Norio Ohmagari, and Tetsuya Hayashi. "Evaluation of the Correspondence between the Concentration of Antimicrobials Entering Sewage Treatment Plant Influent and the Predicted Concentration of Antimicrobials Using Annual Sales, Shipping, and Prescriptions Data." Antibiotics 11, no. 4 (April 1, 2022): 472. http://dx.doi.org/10.3390/antibiotics11040472.

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The accuracy and correspondence between the measured concentrations from the survey and predicted concentrations on the basis of the three types of statistical antimicrobial use in Japan was evaluated. A monitoring survey of ten representative antimicrobials: ampicillin (APL), cefdinir (CDN), cefpodoxime proxetil (CPXP), ciprofloxacin (CFX), clarithromycin (CTM), doxycycline (DCL), levofloxacin (LFX), minocycline (MCL), tetracycline (TCL), and vancomycin (VMC), in the influent of sewage treatment plant (STP) located in urban areas of Japan, was conducted. Then, the measured values were verified in comparison with the predicted values estimated from the shipping volumes, sales volumes, and prescription volumes based on the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB). The results indicate that the correspondence ratios between the predicted concentrations calculated on the basis of shipping and NDB volumes and the measured concentrations (predicted concentration/measured concentration) generally agreed for the detected concentration of antimicrobials in the STP influent. The correspondence ratio on the basis of shipping volume was, for CFX, 0.1; CTM, 2.9; LFX, 0.5; MCL, 1.9; and VMC, 1.7, and on the basis of NDB volume the measured concentration was CFX, 0.1; CTM, 3.7; DCL, 0.4; LFX, 0.7; MCL, 1.9; TCL, 0.6; and VMC, 1.6. To our knowledge, this is the first report to evaluate the accuracy of predicted concentrations based on sales, shipping, NDB statistics and measured concentrations for antimicrobials in the STP influent.

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Ma, Jinglin, Yanrong Liu, Yongpeng Guo, Qiugang Ma, Cheng Ji, and Lihong Zhao. "Transcriptional Profiling of Aflatoxin B1-Induced Oxidative Stress and Inflammatory Response in Macrophages." Toxins 13, no. 6 (June 4, 2021): 401. http://dx.doi.org/10.3390/toxins13060401.

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Aflatoxin B1 (AFB1) is a highly toxic mycotoxin that causes severe suppression of the immune system of humans and animals, as well as enhances reactive oxygen species (ROS) formation, causing oxidative damage. However, the mechanisms underlying the ROS formation and immunotoxicity of AFB1 are poorly understood. This study used the mouse macrophage RAW264.7 cell line and whole-transcriptome sequencing (RNA-Seq) technology to address this knowledge-gap. The results show that AFB1 induced the decrease of cell viability in a dose- and time-dependent manner. AFB1 also significantly increased intracellular productions of ROS and malondialdehyde and decreased glutathione levels. These changes correlated with increased mRNA expression of NOS2, TNF-α and CXCL2 and decreased expression of CD86. In total, 783 differentially expressed genes (DEGs) were identified via RNA-Seq technology. KEGG analysis of the oxidative phosphorylation pathway revealed that mRNA levels of ND1, ND2, ND3, ND4, ND4L, ND5, ND6, Cyt b, COX2, ATPeF0A and ATPeF08 were higher in AFB1-treated cells than control cells, whereas 14 DEGs were downregulated in the AFB1 group. Furthermore, seven immune regulatory pathways mediated by oxidative stress were identified by KEGG analysis. Altogether, these data suggest that AFB1 induces oxidative stress in macrophages via affecting the respiratory chain, which leads to the activation of several signaling pathways related to the inflammatory response.

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Wang, Buhai, Yaqin Fan, Liying Zhang, Liqin Liu, Yutong Ma, Xiaosong Ma, Yuxiang Huang, et al. "Evaluation of Pembrolizumab Monotherapy Efficacy in Advanced Non-Small-Cell Lung Cancer by Serial Monitoring of Circulating Tumor DNA Using Next-Generation Sequencing." Clinical Medicine Insights: Oncology 16 (January 2022): 117955492210753. http://dx.doi.org/10.1177/11795549221075326.

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Introduction: Pembrolizumab is widely used in advanced non-small-cell lung cancer (NSCLC) patients with positive programmed death-ligand 1 (PD-L1). However, efficacy evaluation along treatment by serial monitoring of circulating tumor DNA (ctDNA) using next-generation sequencing remained to be well studied. Methods: Nine PD-L1 positive advanced NSCLC patients were prospectively enrolled and received pembrolizumab monotherapy. Pretreatment tissue and/or plasma samples were collected as baseline reference. Serial plasma samples were collected after 3 and 6 weeks of treatment as well as at disease progression. All samples underwent targeted next-generation sequencing. Results: The median progression-free survival (mPFS) and median overall survival (mOS) were 4.43 and 25.53 months, respectively. In total, 3 patients achieved partial response (PR) or stable disease (SD) for more than 6 months and were thus classified into the durable clinical benefit (DCB) group, whereas the rest 6 were grouped as nondurable benefit (NDB) patients. Molecular profiling of baseline samples revealed that TP53 and APC were the 2 most frequently mutated genes in all patients, whereas POT1 and SETD2 mutations were enriched in DCB and NDB groups, respectively. Higher tumor mutational burden (TMB) was observed in DCB patients than NDB group. During serial ctDNA monitoring, 2 DCB patients showed a dramatic ctDNA reduction while 75% of NDB patients’ ctDNA concentration increased at week 6. Several acquired mutations might contribute to the pembrolizumab resistance, including CDKN2A frameshift and MITF nonsense mutations. Conclusions: Genomic profiling of peripheral blood samples can be applied to dynamically monitor disease progression. The reduction in ctDNA concentration during treatment implied DCBs.

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Penrod, Janice, Fang Yu, Ann Kolanowski, Donna M. Fick, Susan J. Loeb, and Judith E. Hupcey. "Reframing Person-Centered Nursing Care for Persons With Dementia." Research and Theory for Nursing Practice 21, no. 1 (March 2007): 57–72. http://dx.doi.org/10.1891/rtnpij-v21i1a007.

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Alzheimer’s dementia manifests in a complex clinical presentation that has been addressed from both biomedical and phenomenological perspectives. Although each of these paradigmatic perspectives has contributed to advancement of the science, neither is adequate for theoretically framing a person-centered approach to nursing care. The need-driven dementia-compromised behavior (NDB) model is discussed as an exemplar of midrange nursing theory that promotes the integration of these paradigmatic views to promote a new level of excellence in person-centered dementia care. Clinical application of the NDB promotes a new level of praxis, or thoughtful action, in the care of persons with dementia.

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Han, Wei, Hao Zhang, Jian Chen, Yanming Zhao, Qinghua Fan, and Qidong Li. "Synthesis of single-crystalline NdB6 submicroawls via a simple flux-controlled self-catalyzed method." RSC Advances 5, no. 17 (2015): 12605–12. http://dx.doi.org/10.1039/c4ra13129k.

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Katzman, Ju Hee, Cristina Vanessa Garcia, Seetha Lakshmi, Peggy Thompson, and Lennox Archibald. "1464. The Utility of Double Balloon Urinary Catheter in Reducing Rates of Catheter-Associated Urinary Tract Infections in a Tertiary Care Teaching Hospital." Open Forum Infectious Diseases 6, Supplement_2 (October 2019): S534. http://dx.doi.org/10.1093/ofid/ofz360.1328.

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Abstract Background Catheter-associated urinary tract infections (CAUTI) have been shown to increase hospital length of stay, healthcare costs, morbidity, and mortality. Studies that evaluate the role of urinary catheter design in preventing CAUTI are lacking. One such design is the double-balloon (DB) urinary catheter that has a second distal balloon; this design is aimed at reducing mucosal injury and inhibiting coiling of the in situ catheter. We carried out a comparative study to (a) determine whether CAUTI rates differ for different types of urinary catheters, and (b) identify risk factors associated with the acquisition of CAUTI in patients with DB vs. non-double-balloon (NDB) urinary catheters. Methods We conducted a retrospective cohort study of all patients who acquired CAUTI from January 2017 through December 2018. We collected age, sex, body mass index, medical history including benign prostatic hypertrophy, urinary tract infection (UTI), prostate cancer, stroke, surgery within the last 30 days including the type of surgery, indication for indwelling urinary catheter, location of catheter insertion, duration of catheterization, presence of pyuria, and type of catheter used. Statistical analyses were carried out using IBM SPSS software. Test statistics included independent sample t-test. CAUTI rates were expressed per 1000 catheter-days. Results Sixty-seven patients acquired CAUTI during the study period. NDB catheters included the following types: Foley, temperature sensing catheters, and coude catheters. Patients with DB and NDB catheters were similar in age, gender, diabetes, history of stroke, history of recent surgery, or history of UTI. CAUTI rates among patients with the DB catheters was 28 events per 29,018 catheter-days vs. 39 events per 33,579 catheter days for NDB type (P = NS). On stratification, CAUTI rates for foley, temperature sensing catheters, and coude catheters were 1.12, 1.27 and 2.70, respectively (P = NS). Conclusion There were no statistically significant differences in CAUTI rates at our facility among patients with DB vs. NDB urinary catheters. The decision on the choice of the catheter for use in our facility will likely depend on the comparative costs of the respective catheters. Disclosures All authors: No reported disclosures.

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Clauson, Milo, Jeffrey J. Morrell, Bennett Romanaggi, and Arijit Sinha. "Nondestructive bending tests on Douglas-fir utility poles as a potential tool for pole sorting and for prediction of their behavior in service." Holzforschung 71, no. 5 (May 1, 2017): 397–403. http://dx.doi.org/10.1515/hf-2016-0155.

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Abstract Wood poles are a critical part of the electrical transmission system in North America. Wood poles are normally selected on the basis of visual features such as knots, slope of grain or other defects, but there is currently no simple, nondestructive bending (NDB), pre-flexural testing for sorting poles prior to use. In the present paper, the potential for NDB based on bending below the proportional limit was examined to calculate modulus of elasticity (MOE) and thereby predict actual modulus of rupture as determined by destructive bending (MORDB). The investigation was performed on 92 full length 13.3-m long Douglas-fir pole sections. Pre-flexural testing was reasonably correlated with MOEDB, but less well correlated with MORDB. The testing also revealed that visual selection of the best face of a pole, which is used to select a pole oriented to line direction (the “best face”), was poorly correlated with pre-flexing. Increasing the number of NDB tests did not noticeably improve the prediction. The results suggest that pre-flexing might be useful for identifying poles’ performance in service, if more data are available.

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Blahó, andrás. "New Development Bank (NDB): Hopes and Reality." E-conom 3, no. 2 (2015): 2–17. http://dx.doi.org/10.17836/ec.2014.2.002.

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Zhu, Guangsheng, Dian Ren, Xi Lei, Ruifeng Shi, Shuai Zhu, Ning Zhou, Lingling Zu, Ramon Mello, Jun Chen, and Song XU. "Mutations Associated with No Durable Clinical Benefit to Immune Checkpoint Blockade in Non-S-Cell Lung Cancer." Cancers 13, no. 6 (March 19, 2021): 1397. http://dx.doi.org/10.3390/cancers13061397.

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(1) Background: The immune checkpoint blockade (ICB) has shown promising efficacy in non-small-cell lung cancer (NSCLC) patients with significant clinical benefits and durable responses, but the overall response rate to ICBs is only 20%. The lack of responsiveness to ICBs is currently a central problem in cancer immunotherapy. (2) Methods: Four public cohorts comprising 2986 patients with NSCLC were included in the study. We screened 158 patients with NSCLC with no durable clinical benefit (NDB) to ICBs in the Rizvi cohort and identified NDB-related gene mutations in these patients using univariate and multivariate Cox regression analyses. Programmed death-ligand 1 (PD-L1) expression, tumor mutation burden (TMB), neoantigen load, tumor-infiltrating lymphocytes, and immune-related gene expression were analyzed for identifying gene mutations. A comprehensive predictive classifier model was also built to evaluate the efficacy of ICB therapy. (3) Results: Mutations in FAT1 and KEAP1 were found to correlate with NDB in patients with NSCLC to ICBs; however, the analysis suggested that only mutation in FAT1 was valuable in predicting the efficacy of ICB therapy, and that mutation in KEAP1 acted as a prognostic but not a predictive biomarker for NSCLC. Mutations in FAT1 were associated with a higher TMB and lower multiple lymphocyte infiltration, including CD8 (T-Cell Surface Glycoprotein CD8)+ T cells. We established a prognostic model according to PD-L1 expression, TMB, smoking status, treatment regimen, treatment type, and FAT1 mutation, which indicated good accuracy by receiver operating characteristic (ROC) analysis (area under the curve (AUC) for 6-months survival: 0.763; AUC for 12-months survival: 0.871). (4) Conclusions: Mutation in FAT1 may be a predictive biomarker in patients with NSCLC who exhibit NDB to ICBs. We proposed an FAT1 mutation-based model for screening more suitable NSCLC patients to receive ICBs that may contribute to individualized immunotherapy.

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Han, Wei, Yanming Zhao, Qinghua Fan, and Qidong Li. "Preparation and growth mechanism of one-dimensional NdB6 nanostructures: nanobelts, nanoawls, and nanotubes." RSC Advances 6, no. 48 (2016): 41891–96. http://dx.doi.org/10.1039/c6ra02000c.

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HOLZMANN, ROBERT, and ALAIN JOUSTEN. "Conceptualizing, measuring and financing the legacy costs in an NDC reform." Journal of Pension Economics and Finance 11, no. 4 (July 9, 2012): 606–30. http://dx.doi.org/10.1017/s1474747212000121.

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AbstractThe paper provides a framework for the conceptualization, definition and measurement of the legacy costs that needs to be addressed in a reform that transforms an unfunded (or non-financial) defined benefit (NDB) scheme into an equally unfunded notional (or non-financial) defined contribution (NDC) scheme. During a transition from NDB to NDC a financing gap typically arises due to accrued to date liabilities from the old system in excess of the NDC scheme's sustainable flow of benefits. This gap – or legacy cost – needs to be estimated and best explicitly financed. We illustrate different techniques to gauge the scope of the cost. The paper applies the proposed approach to a hypothetical NDC reform in China.

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Copaciu, Florina-Maria, Dorina Simedru, and Maria-Virginia Coman. "Determination of Three Chromium Textile Azo Dyes in Wastewater by SPE-LC-ESI(–)-MS/MS." Journal of AOAC INTERNATIONAL 101, no. 5 (September 1, 2018): 1422–28. http://dx.doi.org/10.5740/jaoacint.18-0059.

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Abstract In the present work, a procedure to determine three textile azo dyes, chromium-complexes [Nylosan Dark Brown (NDB), Lanasyn Dark Brown (LDB), and Lanasyn Red (LR)], from wastewater using solid-phase extraction (SPE) followed by LC-electrospray ionization negative mode tandem mass spectrometry (LC-ESI(–)-MS/MS) has been developed. The extraction/concentration and recovery degree of these dyes from liquid matrices were done on Strata WAX/NH2 cartridges. The chromatographic separation was performed using a Luna C18 (2) 100Å column by isocratic elution with a methanol–acetonitrile–water (0.2% formic acid and 2 mM ammonium formate) mixture. The linearity, the LOD, and the LOQ were determined for each textile dye. The accuracy, the precision (intra- and inter-day), and the matrix effect were also performed for the validation of the developed procedure. These chromium-complex azo dyes often used in the dyeing process by a textile factory in Romania were monitored in the influent and effluent wastewater from a treatment plant situated in its area. Applying the developed SPE-LC-ESI(–)-MS/MS procedure, the following textile dyes were detected (ng/L) in the collected wastewater samples during a 24-h period: NDB 150.1, LDB 200.6, and LR 89.0–244.0 in influents and NDB 22.8, LDB 78.6, and LR 74.0 in effluents.

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Bezerra, Valdir da Silva. "Institutionalization of the BRICS discourse: How does the NDB embody the group’s views on global financial governance?" BRICS Journal of Economics 4, no. 1 (December 28, 2020): 70–81. http://dx.doi.org/10.38050/2712-7508-2020-1-4-7.

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The architecture of global financial governance has recently been complemented by emerging economies’ efforts to coordinate policies, as exemplified by new coalitions of states and a new set of non-Western international institutions. BRICS, in its turn, has made a significant contribution in this direction by establishing the New Development Bank — an alternative to traditional mechanisms of financing development projects with an emphasis on sustainability. As a representative of the growing cooperation of the BRICS countries in recent decades, the NDB highlights most of the group’s views on financial governance. This paper applies a qualitative/analytical approach to the BRICS and NDB Communiqués and practices in order to demonstrate how the bank has managed to successfully institutionalize the group’s discourse over time.

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Piechota, Janusz, Rafał Tomecki, Kamil Gewartowski, Roman Szczesny, Aleksandra Dmochowska, Marek Kudła, Lien Dybczyńska, Piotr P. Stepien, and Ewa Bartnik. "Differential stability of mitochondrial mRNA in HeLa cells." Acta Biochimica Polonica 53, no. 1 (December 21, 2005): 157–67. http://dx.doi.org/10.18388/abp.2006_3374.

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The physiological significance and metabolism of oligoadenylated and polyadenylated human mitochondrial mRNAs are not known to date. After study of eight mitochondrial transcripts (ND1, ND2, ND3, ND5, CO1, CO2, ATP6/8 and Cyt. b) we found a direct correlation between the half-lives of mitochondrial mRNAs and their steady-state levels. Investigation of the mt-mRNA decay after thiamphenicol treatment indicated that three transcripts (ND2, ND3 and Cyt. b) are significantly stabilized after inhibition of mitochondrial translation. Careful analysis one of them, ND3, showed that inaccurate processing of the H-strand RNA precursor may occasionally occur between the ND3 and tRNA(Arg) locus leading to synthesis of ND3 mRNAs lacking the STOP codon. However, analysis of the oligo(A) fraction observed in case of the ND3 indicates that partially polyadenylated mRNAs are linked rather to the transcription process than to the translation-dependent deadenylation. Analysis of ND3 mRNA turnover in cells with siRNA-mediated knock-down of the mitochondrial poly(A) polymerase shows that strongly decreased polyadenylation does not markedly affect the decay of this transcript. We present a model where oligoadenylated mitochondrial transcripts are precursors of molecules containing full length poly(A) tails.

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Anisimov, M. A., A. V. Bogach, V. V. Glushkov, S. V. Demishev, N. A. Samarin, N. Y. Shitsevalova, and N. E. Sluchanko. "Hall Effect in LaB₆ and NdB₆." Solid State Phenomena 152-153 (April 2009): 525–28. http://dx.doi.org/10.4028/www.scientific.net/ssp.152-153.525.

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To shed more light on the peculiarities of ground state formation in RB6 Hall effect in NdB6 and LaB6 has been investigated on the single crystals at temperatures 2K<T<300K in magnetic fields H < 80kOe. The Hall coefficient RH and resistivity ρ have been measured by the sample rotation technique in fixed magnetic field to be perpendicular to the axis of rotation (<110> for LaB6 and <100> for NdB6). A very similar temperature behavior of RH(T) with the step–like anomaly near T ~ 25K has been established for both magnetic NdB6 and diamagnetic LaB6 at intermediate temperatures T>10K. The temperature independent behaviour of Hall coefficient (RH(LaB6) ~ –3.6•10-4 cm3/C, RH(NdB6) ~ –3.7•10-4 cm3/C) observed in the interval 10K<T<20K allowed to estimate the reduced charge carriers’ concentration n/nR ≈ 1.21±0.03 (nR– the concentration of La (Nd) ions). The Hall mobility μH = RH(T)/ρ(T) estimated for LaB6 and NdB6 was shown to be well fitted by the power law μH ~ T-α where α(LaB6) ≈ 1.5, α(NdB6) ≈ 0.6 at the intermediate temperatures 50K<T<300K and α(LaB6) ≈ 3 in the range 20K<T<50K. The drastic decrease of both the Hall mobility μH and the exponent α is discussed in terms of the magnetic scattering enhancement of conduction electrons on the localized 4ƒ–states of Nd3+ ions.

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Yasunaga, Hideo. "Real World Data in Japan: Chapter I NDB." Annals of Clinical Epidemiology 1, no. 2 (2019): 28–30. http://dx.doi.org/10.37737/ace.1.2_28.

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Giannotti, Fosca, and Dino Pedreschi. "Datalog with non-deterministic choice computes NDB-PTIME." Journal of Logic Programming 35, no. 1 (April 1998): 79–101. http://dx.doi.org/10.1016/s0743-1066(97)10004-8.

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Bydder, Mark, Tanya Chavez, Jessica Lam, Walter Henderson, Nick Pinto, Roxana Chavarria, Alex D. Pham, et al. "Triglyceride Saturation in Patients at Risk of NASH and NAFLD: A Cross-Sectional Study." Biophysica 2, no. 1 (December 30, 2021): 8–15. http://dx.doi.org/10.3390/biophysica2010002.

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Chemical shift magnetic resonance imaging (MRI) is commonly used to estimate the amount of fat in tissues, namely the proton density fat fraction (PDFF). In addition to PDFF, the type of fat can be inferred and characterized in terms of the number of double bonds (NDB), number of methylene-interrupted double bonds (NMIDB) and the chain length (CL) of the fatty acid chains. The saturation index is potentially a marker for metabolic disorders. This study assesses the feasibility of estimating these parameters independently or in a constrained manner. Correlations with spectroscopy were measured in 109 subjects’ subcutaneous and visceral fat depots (p = 2 × 10−28), and with the NAFLD Activity Score (NAS) from histological evaluation of biopsies. The findings indicate that imaging estimates are comparable to spectroscopy (p = 0.0002), but there is no significant association of NDB with NAS (p = 0.1).

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De Sá, Rafaela Mello Rodrigues. "A Atuação do Novo Banco de Desenvolvimento dos BRICS no Enfrentamento da Pandemia de Covid-19 l The BRICS New Development Bank's Role in Overcoming The Effects of Covid-19 Pandemic." Revista Neiba, Cadernos Argentina Brasil 10, no. 1 (November 19, 2021): e58900. http://dx.doi.org/10.12957/neiba.2021.58900.

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Desde o final de 2019, o mundo vem lidando com desafios gerados pela pandemia da Covid-19. Os países que compõem o BRICS têm enfrentado grandes dificuldades, pois todos possuem características que facilitam o contágio do vírus, como por exemplo uma numerosa população. A China foi a primeira a enfrentar a crise, e agora os outros países do BRICS se encontram em posições elevadas no ranking mundial com mais casos de Covid-19. Dessa maneira, o presente artigo visa analisar de que forma o Novo Banco de Desenvolvimento (NBD) vem atuando durante o período de crise econômica gerada pela pandemia, examinando os pacotes de assistência direcionados aos países do BRICS. A partir da análise de documentos oficiais e projetos aprovados pelo banco, é possível constatar que a atuação do NBD é relevante para seus países-membros, os quais já obtiveram US$9 bilhões aprovados pela instituição direcionados ao enfrentamento da pandemia.Palavras-chave: Novo Banco de Desenvolvimento; Covid-19; BRICS.ABSTRACTSince the end of 2019, the world has been dealing with challenges generated by the Covid-19 pandemic. The countries that make up the BRICS have faced great difficulties, mainly because all of them have characteristics that facilitate contagion, such as a large population. China was the first to face the crisis, and now the other BRICS countries are in high positions in the world ranking with more cases of Covid-19. Thus, the present article aims to analyze how the New Development Bank (NDB) has been acting during the period of economic crisis generated by the pandemic, examining the assistance packages targeted at the BRICS countries. From the analysis of official documents and projects approved by the bank, it can be seen that the performance of NDB is relevant for its member countries, which have already obtained US$ 9 billion approved by the institution.Keywords: New Development Bank; COVID-19; BRICS. Recebido em: 03/04/2021 | Aceito em: 14/09/2021.

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BLAIR, D., T. H. LE, L. DESPRÉS, and D. P. McMANUS. "Mitochondrial genes of Schistosoma mansoni." Parasitology 119, no. 3 (September 1999): 303–13. http://dx.doi.org/10.1017/s0031182099004709.

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Two clones, totalling 8068 bp and spanning over half of the coding region of the mitochondrial genome of Schistosoma mansoni, have been sequenced. Complete sequences are presented of the large and small ribosomal RNA subunits, CO2, ND3, ND4, ND6 and ATPase 6 genes. Incomplete sequences were found for the CO1, ND2 and CytB genes. At least 10 tRNAs were also detected and alternative structures for some of these discussed. The gene order of S. mansoni is unique and differs from that of Fasciola hepatica, the only other trematode for which any information is available.

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Gasparik, Cristina, Manuela Maria Manziuc, Alexandru Victor Burde, Javier Ruiz-López, Smaranda Buduru, and Diana Dudea. "Masking Ability of Monolithic and Layered Zirconia Crowns on Discolored Substrates." Materials 15, no. 6 (March 17, 2022): 2233. http://dx.doi.org/10.3390/ma15062233.

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There is scarce information on the colorimetric behavior of monolithic and layered zirconia crowns in combination with various abutment colors. This study evaluated the masking ability on discolored substrates of monolithic and layered zirconia crowns. Anterior crowns were fabricated using 3Y-TZP zirconia and layering ceramic and divided into three groups: monolithic (ML), bi-layer (BL), and tri-layer (TL). The crowns were placed over eleven substrates (ND1-ND9, zirconia, metal), and CIE L*, a*, b*, C*, and h° color coordinates were measured in the cervical, middle, and incisal areas with a spectrophotometer. Masking ability was calculated using the color difference formula, and values were interpreted according to the perceptibility and acceptability thresholds. Data were analyzed statistically (α = 0.001). The L* coordinate was not significantly different between BL and TL crowns, regardless of the measurement area or substrate (p ≥ 0.001). In the middle area, the L* coordinate of the ML group was statistically different from the BL and TL groups only for zirconia and metal substrates, while in the incisal area, only for ND7 and metal substrates. The a* coordinate was significantly different between the ML and layered crowns for all measurement areas and substrates (except zirconia). The b* and C* coordinates differed significantly between the groups only in the cervical area (p < 0.001). The ML crown had better masking ability than the BL and TL crowns. However, the color differences for ML crowns were below the acceptability threshold for ND2, ND3, and ND7 substrates in the cervical and middle areas and below perceptibility threshold only for the incisal area. The lowest masking ability of the crowns was found for ND9 and metal substrates in all measurement areas.

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Berman, Helen M., Christine Zardecki, and John Westbrook. "The Nucleic Acid Database: A Resource for Nucleic Acid Science." Acta Crystallographica Section D Biological Crystallography 54, no. 6 (November 1, 1998): 1095–104. http://dx.doi.org/10.1107/s0907444998007926.

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The Nucleic Acid Database (NDB) distributes information about nucleic acid-containing structures. Here the information content of the database as well as the query capabilities are described. A summary of how the technology developed by this project has been used to develop other macromolecular databases is given.

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Smogorzewski, Kamil. "AIIB i NDB – fundamenty geopolitycznej strategii Chińskiej Republiki Ludowej." Azja-Pacyfik 20, no. 1 (December 31, 2017): 82–97. http://dx.doi.org/10.15804/ap201704.

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George, Chris. "The NDB database specified in the RAISE specification language." Formal Aspects of Computing 4, no. 1 (January 1992): 48–75. http://dx.doi.org/10.1007/bf01214956.

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Škvareková, Iveta, Pavol Pecho, and Július Fedáš. "Measurement of Pilot's Workload During NDB and ILS Approaches." Transportation Research Procedia 59 (2021): 14–20. http://dx.doi.org/10.1016/j.trpro.2021.11.092.

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Kowal, Krzysztof, Angelika Tkaczyk, Tomasz Ząbek, Mariusz Pierzchała, and Brygida Ślaska. "Comparative Analysis of CpG Sites and Islands Distributed in Mitochondrial DNA of Model Organisms." Animals 10, no. 4 (April 11, 2020): 665. http://dx.doi.org/10.3390/ani10040665.

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The information about mtDNA methylation is still limited, thus epigenetic modification remains unclear. The lack of comprehensive information on the comparative epigenomics of mtDNA prompts comprehensive investigations of the epigenomic modification of mtDNA in different species. This is the first study in which the theoretical CpG localization in the mtDNA reference sequences from various species (12) was compared. The aim of the study was to determine the localization of CpG sites and islands in mtDNA of model organisms and to compare their distribution. The results are suitable for further investigations of mtDNA methylation. The analysis involved both strands of mtDNA sequences of animal model organisms representing different taxonomic groups of invertebrates and vertebrates. For each sequence, such parameters as the number, length, and localization of CpG islands were determined with the use of EMBOSS (European Molecular Biology Open Software Suite) software. The number of CpG sites for each sequence was indicated using the newcpgseek algorithm. The results showed that methylation of mtDNA in the analysed species involved mitochondrial gene expression. Our analyses showed that the CpG sites were commonly present in genomic regions including the D-loop, CYTB, ND6, ND5, ND4, ND3, ND2, ND1, COX3, COX2, COX1, ATP6, 16s rRNA, and 12s rRNA. The CpG distribution in animals from different species was diversified. Generally, the number of observed CpG sites of the mitochondrial genome was higher in the vertebrates than in the invertebrates. However, there was no relationship between the frequency of the CpG sites in the mitochondrial genome and the complexity of the analysed organisms. Interestingly, the distribution of the CpG sites for tRNA coding genes was usually cumulated in a larger CpG region in vertebrates. This paper may be a starting point for further research, since the collected information indicates possible methylation regions localized in mtDNA among different species including invertebrates and vertebrates.

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Carvalho, Evandro Menezes de. "A segunda década do BRICS." Idéias 9, no. 2 (December 14, 2018): 265–92. http://dx.doi.org/10.20396/ideias.v9i2.8655191.

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Introdução: BRICS e a agenda reformista; 2) A agenda reformista pela vertente econômica para além dos contornos do BRICS: o Novo Banco de Desenvolvimento (NDB); 3) A agenda reformista pela vertente política para além dos contornos do BRICS: Diálogos de outreach e BRICS Plus; 4) A XI Cúpula do BRICS e o desafio intra-BRICS; 5) Considerações finais.

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Agrawal, Vartika, Yee Him Cheung, Payal Keswarpu, George Somlo, Maysa Abu-Khalaf, William M. Sikov, Vinay Varadan, Lyndsay Harris, and Nevenka Dimitrova. "RNA-Seq to reveal mitochondrial gene fusions in breast cancer." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): e13019-e13019. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e13019.

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e13019 Background: Several mitochondrial DNA (mtDNA) mutations have been identified in various types of human cancer. While gene fusions encoded by the nuclear genome have an important role in tumorigenesis, the contribution of the mitochondrial genome to this process is unclear. mtDNA has limited protective mechanisms compared to that for nuclear DNA (nDNA), and hence more susceptible to genomic aberrations. Methods: We sequenced RNA from pre and post treatment breast cancer samples obtained from neoadjuvant clinical trials BrUOG 211A/211B. Seventy-three of these samples were considered baseline and 61 were from post-treatment samples, 54 samples at both time points. Patients were given a run-in dose of bevacizumab (B), nab- paclitaxel (N) or trastuzumab (T), followed by combination biologic/chemotherapy (HER2- with B/carboplatin/N; HER2+ with T/carboplatin/N). RNA was derived from biopsy pairs obtained pre/post 10-day exposure to run-in monotherapy. We used TopHat-Fusion and deFuse for fusion detection. Results: On average, in each patient 4.6 mtDNA gene fusions were detected at the baseline and 4 in the post treatment samples. In this cohort we detected in total 385 mtDNA fusions across the baseline and 344 across the post-treatment samples. A number of fusions had recurrently shown drastic increase from baseline to post-treatment, such as MT-ATP6:MT-ND2 ( N = 9), MT-ND6:MT-CO2 ( N = 6), MT-ND6:MT-CO1 ( N = 10), and MT-ND4:MT-ATP6 ( N = 9). We observe that some mitochondrial genes such as MT-ND6 have as many as 7 gene partners. MT-ND6 appeared in fusions that were most abundant among both baseline and post-treatment samples with MT:ND4 ( N = 39), MT:ND2 ( N = 37) and MD:ATP6 ( N = 36). Interestingly, gene fusions MT-ND6:J01415.25, MT-CYB:MT-ND2 and MT-ND6:MT-ND1 were observed respectively in 9, 5 and 4 baseline samples but not in their post treatment equivalent. Conclusions: While several studies have examined the presence of mtDNA mutations in breast cancer, the role of mitochondrial gene fusions is unknown in cancer. In our breast cancer cohort we observed quite a high number of mitochondrial fusions, and some of them seem to be recurrent in multiple samples. This could potentially have clinical implications as knowledge of fusions in solid tumours gains.

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Sellmyer, D. J., Z. R. Zhao, Z. S. Shan, and J. G. Zhao. "Permanent magnet properties of sputter‐deposited (FeCo)NdB films (abstract)." Journal of Applied Physics 61, no. 8 (April 15, 1987): 3779. http://dx.doi.org/10.1063/1.338642.

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Sarhan, Mohammad Abdelfattah. "Assessing hydrocarbon prospects in Abu Madi formation using well logging data in El-Qara field, Nile Delta Basin, Egypt." Journal of Petroleum Exploration and Production Technology 11, no. 6 (June 2021): 2539–59. http://dx.doi.org/10.1007/s13202-021-01214-1.

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AbstractIn this work, the petrophysical properties of Abu Madi reservoir in El-Qara Field at northern Nile Delta Basin (NDB) were evaluated depending on well logging data of two wells: El-Qara-2 and El-Qara-3. This evaluation revealed that in El-Qara-2 well, the promising gas zone is detected between depths of 3315 and 3358 m, while in El-Qara-3 well, the best gas interval is detected between depths of 3358 and 3371 m. In addition to the production test parameters (gas rate, condensate rate, gas gravity, condensate gravity, gas-to-oil ratio, flowing tubing head pressure, flowing bottom hole pressure, and static bottom hole pressure), the calculated petrophysical parameters (shale volume, total porosity, effective porosity, and water saturation) for both intervals were relatively similar. This confirms that the investigated wells were drilled at the same reservoir interval within Abu Madi Fm. The depth variation in the examined zones was attributed to the presence of buried normal faults between El-Qara-2 and El-Qara-3 wells. This observation may be supported from the tectonic influence during the deposition of Abu Madi Fm. as a portion of the Messinian syn-rift megasequence beneath the NDB.

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Rizvi, Hira, Francisco Sanchez-Vega, Konnor La, Walid Chatila, Philip Jonsson, Darragh Halpenny, Andrew Plodkowski, et al. "Molecular Determinants of Response to Anti–Programmed Cell Death (PD)-1 and Anti–Programmed Death-Ligand 1 (PD-L1) Blockade in Patients With Non–Small-Cell Lung Cancer Profiled With Targeted Next-Generation Sequencing." Journal of Clinical Oncology 36, no. 7 (March 1, 2018): 633–41. http://dx.doi.org/10.1200/jco.2017.75.3384.

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Purpose Treatment of advanced non–small-cell lung cancer with immune checkpoint inhibitors (ICIs) is characterized by durable responses and improved survival in a subset of patients. Clinically available tools to optimize use of ICIs and understand the molecular determinants of response are needed. Targeted next-generation sequencing (NGS) is increasingly routine, but its role in identifying predictors of response to ICIs is not known. Methods Detailed clinical annotation and response data were collected for patients with advanced non–small-cell lung cancer treated with anti–programmed death-1 or anti–programmed death-ligand 1 [anti-programmed cell death (PD)-1] therapy and profiled by targeted NGS (MSK-IMPACT; n = 240). Efficacy was assessed by Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1, and durable clinical benefit (DCB) was defined as partial response/stable disease that lasted > 6 months. Tumor mutation burden (TMB), fraction of copy number–altered genome, and gene alterations were compared among patients with DCB and no durable benefit (NDB). Whole-exome sequencing (WES) was performed for 49 patients to compare quantification of TMB by targeted NGS versus WES. Results Estimates of TMB by targeted NGS correlated well with WES (ρ = 0.86; P < .001). TMB was greater in patients with DCB than with NDB ( P = .006). DCB was more common, and progression-free survival was longer in patients at increasing thresholds above versus below the 50th percentile of TMB (38.6% v 25.1%; P < .001; hazard ratio, 1.38; P = .024). The fraction of copy number–altered genome was highest in those with NDB. Variants in EGFR and STK11 associated with a lack of benefit. TMB and PD-L1 expression were independent variables, and a composite of TMB plus PD-L1 further enriched for benefit to ICIs. Conclusion Targeted NGS accurately estimates TMB and elevated TMB further improved likelihood of benefit to ICIs. TMB did not correlate with PD-L1 expression; both variables had similar predictive capacity. The incorporation of both TMB and PD-L1 expression into multivariable predictive models should result in greater predictive power.

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Berman, Helen M., John Westbrook, Zukang Feng, Lisa Iype, Bohdan Schneider, and Christine Zardecki. "The Nucleic Acid Database." Acta Crystallographica Section D Biological Crystallography 58, no. 6 (May 29, 2002): 889–98. http://dx.doi.org/10.1107/s0907444902003487.

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The Nucleic Acid Database was established in 1991 as a resource to assemble and distribute structural information about nucleic acids. Over the years, the NDB has developed generalized software for processing, archiving, querying and distributing structural data for nucleic acid-containing structures. The architecture and capabilities of the Nucleic Acid Database, as well as some of the research enabled by this resource, are presented in this article.

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Sobenin, Igor A., Margarita A. Sazonova, Anton Y. Postnov, Yuri V. Bobryshev, and Alexander N. Orekhov. "Mitochondrial Mutations are Associated with Atherosclerotic Lesions in the Human Aorta." Clinical and Developmental Immunology 2012 (2012): 1–5. http://dx.doi.org/10.1155/2012/832464.

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Somatic mutations of the human mitochondrial genome can be a possible determinant of atherosclerosis. To test this possibility, forty mitochondrial mutations were analyzed in the present study in order to see which of these mutations might be associated with atherosclerosis. Ten mitochondrial mutations belonging to mitochondrial genes MT-RNR1 (rRNA 12S); MT-TL1 (tRNA-Leu, recognizes UUR); MT-TL2 (tRNA-Leu, recognizes CUN); MT-ND1, MT-ND2, MT-ND5, and MT-ND6 (subunits 1, 2, 5, and 6, respectively, of NADH dehydrogenase); and MT-CYB (cytochrome b) were potentially associated with atherosclerosis. From 29% (2 of 7 aortic samples) upto 86% (6 of 7 aortic samples) of aortic samples had a significant difference between atherosclerotic plaques and unaffected tissue, with the respect to the level of heteroplasmy for each mutation. Further, the homogenates of affected and normal intimae of 22 aortas were compared to reveal the average level of heteroplasmy for the above-mentioned 10 mutations. For five mutations, the mean level of heteroplasmy was significantly different in atherosclerotic intimal homogenates in comparison with the unaffected tissue. These mutations were A1555G, C3256T, T3336C, G13513A, and G15059A. Thus, it was demonstrated that at least five mitochondrial mutations occurring in MT-RNR1, MT-TL1, MT-ND2, MT-ND5, and MT-CYB genes are associated with atherosclerosis.

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Reisen, Helmut. "Will the AIIB and the NDB Help Reform Multilateral Development Banking?" Global Policy 6, no. 3 (July 14, 2015): 297–304. http://dx.doi.org/10.1111/1758-5899.12250.

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Journal articles on the topic 'NDB'

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