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Journal articles on the topic 'NDDs'

Author: Grafiati

Published: 30 June 2021

Last updated: 29 July 2025

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1

Jiang, Yongxi, Tianxiu Lu, Jingmin Pi, and Waseem Anwar. "The Retentivity of Four Kinds of Shadowing Properties in Non-Autonomous Discrete Dynamical Systems." Entropy 24, no. 3 (2022): 397. http://dx.doi.org/10.3390/e24030397.

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In this paper, four kinds of shadowing properties in non-autonomous discrete dynamical systems (NDDSs) are discussed. It is pointed out that if an NDDS has a F-shadowing property (resp. ergodic shadowing property, d¯ shadowing property, d̲ shadowing property), then the compound systems, conjugate systems, and product systems all have accordant shadowing properties. Moreover, the set-valued system (K(X),f¯1,∞) induced by the NDDS (X,f1,∞) has the above four shadowing properties, implying that the NDDS (X,f1,∞) has these properties.

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Anilkumar, Adithya K., Puneet Vij, Samantha Lopez, et al. "Long Non-Coding RNAs: New Insights in Neurodegenerative Diseases." International Journal of Molecular Sciences 25, no. 4 (2024): 2268. http://dx.doi.org/10.3390/ijms25042268.

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Neurodegenerative diseases (NDDs), including Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS), are gradually becoming a burden to society. The adverse effects and mortality/morbidity rates associated with these NDDs are a cause of many healthcare concerns. The pathologic alterations of NDDs are related to mitochondrial dysfunction, oxidative stress, and inflammation, which further stimulate the progression of NDDs. Recently, long non-coding RNAs (lncRNAs) have attracted ample attention as critical mediators in the pathology of NDDs. However, there is

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Toledo, Alma Rosa Lezama, Germán Rivera Monroy, Felipe Esparza Salazar, et al. "Gut–Brain Axis as a Pathological and Therapeutic Target for Neurodegenerative Disorders." International Journal of Molecular Sciences 23, no. 3 (2022): 1184. http://dx.doi.org/10.3390/ijms23031184.

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Human lifestyle and dietary behaviors contribute to disease onset and progression. Neurodegenerative diseases (NDDs), considered multifactorial disorders, have been associated with changes in the gut microbiome. NDDs display pathologies that alter brain functions with a tendency to worsen over time. NDDs are a worldwide health problem; in the US alone, 12 million Americans will suffer from NDDs by 2030. While etiology may vary, the gut microbiome serves as a key element underlying NDD development and prognosis. In particular, an inflammation-associated microbiome plagues NDDs. Conversely, sequ

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Dr., C. S. Parameswari* K. Mounika B. Manasa N. Navya sree M. Sreya M. Rajeswari E. Anusha. "Review Article on Novel Drug Delivery System." International Journal of Pharmaceutical Sciences 2, no. 12 (2024): 1055–71. https://doi.org/10.5281/zenodo.14355738.

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The development of novel drug delivery systems (NDDS) has revolutionized the pharmaceutical industry by enhancing therapeutic efficacy, reducing side effects, and improving patient compliance. This thesis provides an overview of NDDS, classifying them into targeted, controlled, and modulated release systems. The significance of polymers in NDDS is highlighted, with a focus on natural, synthetic, biodegradable, conducting, and smart polymers. The advantages of NDDS, including increased bioavailability, reduced toxicity, and improved patient outcomes, are discussed. The thesis also explores vari

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Heuvel, M. Van den, C. Borkhoff, C. Koroshegyi, et al. "How Well Does the Nipissing District Developmental Screen (NDDS) Identify Communication Problems in Infants?" Paediatrics & Child Health 21, Supplement_5 (2016): e74-e74. http://dx.doi.org/10.1093/pch/21.supp5.e74.

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Abstract BACKGROUND: Communication problems are often the first presenting problem in infants with developmental disabilities. With early detection, intervention can start. The 18-month Nipissing District Developmental Screen (NDDS) was created as a developmental checklist for use in primary care. The Infant Toddler Checklist (ITC) is a validated questionnaire for detecting communication problems. Our objective was to examine how well the 18-month NDDS identifies communication problems. We therefore assessed the convergent validity of the 18-month NDDS with the ITC as a gold standard. OBJECTIV

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Banu, Laila Areju Man, FM Anamul Haque, and Saria Tasnim. "Neurodevelopmental Disorders (NDDs) in Children: Role of Maternal Factors." Bangladesh Journal of Obstetrics & Gynaecology 37, no. 2 (2023): 139–47. http://dx.doi.org/10.3329/bjog.v37i2.69033.

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Neurodevelopmental disorders (NDDs) are disabilities affecting normal brain development and function. The early stages of brain development are critical, and disruption of this process results in neurodevelopmental disorders (NDDs) in children. Common neurodevelopmental disorders in children include autism spectrum disease (ASD), attention deficit hyperactivity disorder (ADHD), cerebral palsy (CP), intellectual disability (ID), epilepsy, learning disability, schizophrenia etc. Though the causes of NDDs are multifactorial, epidemiological studies have shown that a number of maternal factors suc

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Wang, Li, Chao-Chao Yu, Xin-Yuan Liu, Xiao-Ni Deng, Qing Tian, and Yan-Jun Du. "Epigenetic Modulation of Microglia Function and Phenotypes in Neurodegenerative Diseases." Neural Plasticity 2021 (May 29, 2021): 1–13. http://dx.doi.org/10.1155/2021/9912686.

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Microglia-mediated neuroinflammation is one of the most remarkable hallmarks of neurodegenerative diseases (NDDs), including AD, PD, and ALS. Accumulating evidence indicates that microglia play both neuroprotective and detrimental roles in the onset and progression of NDDs. Yet, the specific mechanisms of action surrounding microglia are not clear. Modulation of microglia function and phenotypes appears to be a potential strategy to reverse NDDs. Until recently, research into the epigenetic mechanisms of diseases has been gradually developed, making it possible to elucidate the molecular mecha

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8

Sharifi-Rad, Mehdi, Chintha Lankatillake, Daniel A. Dias, et al. "Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics." Journal of Clinical Medicine 9, no. 4 (2020): 1061. http://dx.doi.org/10.3390/jcm9041061.

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Among the major neurodegenerative disorders (NDDs), Alzheimer’s disease (AD) and Parkinson’s disease (PD), are a huge socioeconomic burden. Over many centuries, people have sought a cure for NDDs from the natural herbals. Many medicinal plants and their secondary metabolites are reported with the ability to alleviate the symptoms of NDDs. The major mechanisms identified, through which phytochemicals exert their neuroprotective effects and potential maintenance of neurological health in ageing, include antioxidant, anti-inflammatory, antithrombotic, antiapoptotic, acetylcholinesterase and monoa

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9

Zhang, Xiaoyan, Weithye Lee, and Jinsong Bian. "Recent Advances in the Study of Na+/K+-ATPase in Neurodegenerative Diseases." Cells 11, no. 24 (2022): 4075. http://dx.doi.org/10.3390/cells11244075.

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Na+/K+-ATPase (NKA), a large transmembrane protein, is expressed in the plasma membrane of most eukaryotic cells. It maintains resting membrane potential, cell volume and secondary transcellular transport of other ions and neurotransmitters. NKA consumes about half of the ATP molecules in the brain, which makes NKA highly sensitive to energy deficiency. Neurodegenerative diseases (NDDs) are a group of diseases characterized by chronic, progressive and irreversible neuronal loss in specific brain areas. The pathogenesis of NDDs is sophisticated, involving protein misfolding and aggregation, mit

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10

Barman, Dhunusmita, Nikita Dey, Srijani Sen, Bibhuti Kakoti, and Catherine Vanlalhriatpuii. "Neuromodulatory effect of plant metabolites." Sciences of Phytochemistry 1, no. 1 (2022): 47–69. http://dx.doi.org/10.58920/sciphy01010047.

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Neurological disorders (NDDs) are diseases that affect the central and peripheral nervous systems. Gradual malfunction and destruction of the neurons or the nerve cells characterize them. Every year, NDDs affect millions of people worldwide. Over the years, several neuromodulatory techniques have been introduced to improve the quality of life for those affected by NDDs. NDDs are chronic and incurable conditions, however, bioactive substances derived from medicinal plants have emerged as the greatest choice for their prevention and treatment. Literature evidences several benefits of plant metab

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11

Garcia-Argibay, Miguel, Sebastian Lundström, Samuele Cortese, and Henrik Larsson. "Trends in Body Mass Index Among Individuals With Neurodevelopmental Disorders." JAMA Network Open 7, no. 9 (2024): e2431543. http://dx.doi.org/10.1001/jamanetworkopen.2024.31543.

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ImportanceNeurodevelopmental disorders (NDDs) such as autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are increasingly common. Individuals with NDDs have heightened obesity risks, but long-term data on body mass index (BMI) trends over time in this population are lacking.ObjectiveTo assess secular BMI changes from 2004 to 2020 among children with NDDs compared with those without NDDs.Design, Setting, and ParticipantsThis repeated cross-sectional study used data from the Child and Adolescent Twin Study in Sweden. Children born between January 1, 1992, and Dece

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12

Guo, Li, Bing-Xiao Li, Mei Deng, et al. "Etiological Analysis of Neurodevelopmental Disabilities: Single-Center Eight-Year Clinical Experience in South China." Journal of Biomedicine and Biotechnology 2011 (2011): 1–11. http://dx.doi.org/10.1155/2011/318616.

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Etiology determination of neurodevelopmental disabilities (NDDs) currently remains a worldwide common challenge on child health. We herein reported the etiology distribution feature in a cohort of 285 Chinese patients with NDDs. Although concrete NDD etiologies in 48.4% of the total patients could not be identified, genetic diseases (with the proportion of 35.8% in the total cases) including inborn errors of metabolism (IEM) and congenital dysmorphic diseases, constituted the commonest etiology category for NDDs in this study. The two key experimental technologies in pediatric metabolomics, ga

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13

Aravamuthan, Bhooma R., Michael Shevell, Young-Min Kim, et al. "Role of child neurologists and neurodevelopmentalists in the diagnosis of cerebral palsy." Neurology 95, no. 21 (2020): 962–72. http://dx.doi.org/10.1212/wnl.0000000000011036.

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ObjectiveTo contextualize the role of child neurologists and neurodevelopmentalists (CNs/NDDs) in cerebral palsy (CP) care, we review the changing landscape of CP diagnosis and survey stakeholder CNs/NDDs regarding their roles in CP care.MethodsThe optimal roles of the multiple specialties involved in CP care are currently unclear, particularly regarding CP diagnosis. We developed recommendations regarding the role of CNs/NDDs noting (1) increasing complexity of CP diagnosis given a growing number of genetic etiologies and treatable motor disorders that can be misdiagnosed as CP and (2) the vi

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14

Rao Khadam, Vinay Kumar, Ravindra Pal Singh, Deepak Prajapati, et al. "An Updated Comprehensive Review on Novel Drug Delivery Systems (NDDS) In the Pharmaceuticals." Asian Journal of Pharmaceutical Research and Development 12, no. 1 (2024): 55–64. http://dx.doi.org/10.22270/ajprd.v12i1.1349.

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The field of pharmaceutical sciences has witnessed a paradigm shift with the advent of Novel Drug Delivery Systems (NDDS), which aim to enhance therapeutic efficacy, reduce side effects, and improve patient compliance. This comprehensive review explores the latest advancements and innovations in NDDS, encompassing a diverse range of delivery platforms and strategies.(NDDs are transforming the landscape of pharmaceutical treatment, offering unparalleled potential for enhanced therapeutic efficacy, improved bioavailability, controlled release, targeted delivery, and enhanced stability. This comp

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15

Cousineau, Jason Patrick, Aimee Maria Dawe, and Melanie Alpaugh. "Investigating the Interplay between Cardiovascular and Neurodegenerative Disease." Biology 13, no. 10 (2024): 764. http://dx.doi.org/10.3390/biology13100764.

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Neurological diseases, including neurodegenerative diseases (NDDs), are the primary cause of disability worldwide and the second leading cause of death. The chronic nature of these conditions and the lack of disease-modifying therapies highlight the urgent need for developing effective therapies. To accomplish this, effective models of NDDs are required to increase our understanding of underlying pathophysiology and for evaluating treatment efficacy. Traditionally, models of NDDs have focused on the central nervous system (CNS). However, evidence points to a relationship between systemic facto

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16

Martínez-Iglesias, Olaia, Vinogran Naidoo, Iván Carrera, Lola Corzo, and Ramón Cacabelos. "Natural Bioactive Products as Epigenetic Modulators for Treating Neurodegenerative Disorders." Pharmaceuticals 16, no. 2 (2023): 216. http://dx.doi.org/10.3390/ph16020216.

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Neurodegenerative disorders (NDDs) are major health issues in Western countries. Despite significant efforts, no effective therapeutics for NDDs exist. Several drugs that target epigenetic mechanisms (epidrugs) have been recently developed for the treatment of NDDs, and several of these are currently being tested in clinical trials. Furthermore, various bioproducts have shown important biological effects for the potential prevention and treatment of these disorders. Here, we review the use of natural products as epidrugs to treat NDDs in order to explore the epigenetic effects and benefits of

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17

Smith, Giuditta, Benedetta Bianchi Janetti, Megha Sarin, and Maria Garraffa. "Grammar in Adults with Neurodevelopmental Disorders: A Scoping Review from the Last 10 Years." Languages 8, no. 4 (2023): 248. http://dx.doi.org/10.3390/languages8040248.

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Little is known of the trajectory of grammar in neurodevelopmental disorders (NDDs) once adulthood and language maturity are reached. Yet, impairments in grammar are reported in children with both communication NDDs, such as Developmental Language Disorder (DLD), and other NDDs, including ASD and ADHD. In the present study, we review studies collected in the last ten years on the grammar of adults with NDDs. Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were applied. Included studies assessed sentence-level grammatical abilities through quantitative experiments

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18

Cory-Slechta, Deborah, Marissa Sobolewski, and Günter Oberdörster. "Air Pollution-Related Brain Metal Dyshomeostasis as a Potential Risk Factor for Neurodevelopmental Disorders and Neurodegenerative Diseases." Atmosphere 11, no. 10 (2020): 1098. http://dx.doi.org/10.3390/atmos11101098.

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Increasing evidence links air pollution (AP) exposure to effects on the central nervous system structure and function. Particulate matter AP, especially the ultrafine (nanoparticle) components, can carry numerous metal and trace element contaminants that can reach the brain in utero and after birth. Excess brain exposure to either essential or non-essential elements can result in brain dyshomeostasis, which has been implicated in both neurodevelopmental disorders (NDDs; autism spectrum disorder, schizophrenia, and attention deficit hyperactivity disorder) and neurodegenerative diseases (NDGDs;

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19

Berglund Melendez, Andrea, Maria Malmsten, Eva-Lena Einberg, Eva K. Clausson, and Pernilla Garmy. "Supporting Students with Neurodevelopment Disorders in School Health Care—School Nurses’ Experiences." International Journal of Environmental Research and Public Health 17, no. 16 (2020): 5752. http://dx.doi.org/10.3390/ijerph17165752.

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Students with neurodevelopmental disorders (NDDs) are present in every school, and most likely, there are a few students in every class. School health care is responsible for providing support to all students, especially those with special needs. The aim of the study was to describe school nurses’ experiences of supporting students with NDDs. A qualitative method consisting of seven focus group interviews (that included a total of 35 school nurses) in Southern Sweden was conducted. Three themes were identified in the findings: helping students with NDDs to interpret sensations, detecting early

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20

Soni, Neetu, Manish Ora, Girish Bathla, et al. "Multiparametric magnetic resonance imaging and positron emission tomography findings in neurodegenerative diseases: Current status and future directions." Neuroradiology Journal 34, no. 4 (2021): 263–88. http://dx.doi.org/10.1177/1971400921998968.

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Neurodegenerative diseases (NDDs) are characterized by progressive neuronal loss, leading to dementia and movement disorders. NDDs broadly include Alzheimer’s disease, frontotemporal lobar degeneration, parkinsonian syndromes, and prion diseases. There is an ever-increasing prevalence of mild cognitive impairment and dementia, with an accompanying immense economic impact, prompting efforts aimed at early identification and effective interventions. Neuroimaging is an essential tool for the early diagnosis of NDDs in both clinical and research settings. Structural, functional, and metabolic imag

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Palmieri, Roberta, Valeria Albano, Silvana Guerriero, et al. "Beyond Diagnosis: Preliminary Study of Impact on Children and Parents in Neurodevelopmental Disorders and Juvenile Idiopathic Arthritis-Associated Uveitis." Diagnostics 14, no. 3 (2024): 275. http://dx.doi.org/10.3390/diagnostics14030275.

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Chronic diseases are a growing problem for global health due to the large number of people they involve, the repercussions they have on the mental and physical well-being of those affected, and the costs to society. Particularly, chronic illnesses of childhood have important psychological implications, not only for affected children but also for their parents. Among these pathologies, neurodevelopmental disorders (NDDs) and uveitis associated with juvenile idiopathic arthritis (JIA-U) may affect mental and physical health, emotions, memory, learning, and socializing. This study evaluates the p

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Islam, Md Irteja, Bernadette Yan Yue Lam, Tuguy Esgin, and Alexandra Martiniuk. "Thriving Beyond Adversity: A Prospective Longitudinal Cohort Study Using a Strength-Based Approach Depicts Indigenous Adolescents with Less Adverse Childhood Experiences (ACEs) Had Fewer Neurodevelopmental Disorders (NDDs)." Behavioral Sciences 14, no. 11 (2024): 1047. http://dx.doi.org/10.3390/bs14111047.

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Improving social and emotional well-being (SEWB) among Indigenous adolescents is crucial. Since neurodevelopmental disorders (NDDs) are common in Indigenous people and adverse childhood experiences (ACEs) are important contributors to negative health outcomes throughout the lifespan, we investigated whether limited ACE exposure is associated with reduced risk of NDDs in Australian Indigenous teens using the data from multiple waves (Wave 1 to Wave 9, and Wave 11) of the Longitudinal Study of Indigenous Children (LSIC). We also examined the role of other protective factors, such as Indigenous c

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Bogár, Ferenc, Lívia Fülöp, and Botond Penke. "Novel Therapeutic Target for Prevention of Neurodegenerative Diseases: Modulation of Neuroinflammation with Sig-1R Ligands." Biomolecules 12, no. 3 (2022): 363. http://dx.doi.org/10.3390/biom12030363.

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Neurodegenerative diseases (NDDs) are characterized by progressive deterioration of the structure and function of cells and their networks in the nervous system. There are currently no drugs or other treatments that can stop the progression of NDDs. NDDs have many similarities and common pathways, e.g., formation of misfolded amyloid proteins, intra- and extracellular amyloid deposits, and chronic inflammation. Initially, the inflammation process has a cytoprotective function; however, an elevated and prolonged immune response has damaging effects and causes cell death. Neuroinflammation has b

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Kolpakova, A. F., R. N. Sharipov та O. A. Volkova. "Оn the relationship of neurodergenerative diseases with air pollution by particulate matter". Russian neurological journal 27, № 4 (2022): 5–15. http://dx.doi.org/10.30629/2658-7947-2022-27-4-5-15.

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The review highlights the current understanding of the relationship between particulate matter (PM) in air pollution and the risk of neurodegenerative diseases (NDDs). For this purpose, materials from articles indexed in the PubMed and RSCI databases were used. The results of the short-term and long-term eﬀects of PM on the occurrence and progression of NDDs depending on their size, chemical composition and age of the subjects are considered. PMs with an aerodynamic diameter of ≤ 2.5 microns are recognized as the most dangerous. Epidemiological, clinical and experimental studies have conﬁrmed

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Bravo-Vázquez, Luis Alberto, Erick Octavio Mora-Hernández, Alma L. Rodríguez, et al. "Current Advances of Plant-Based Vaccines for Neurodegenerative Diseases." Pharmaceutics 15, no. 2 (2023): 711. http://dx.doi.org/10.3390/pharmaceutics15020711.

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Neurodegenerative diseases (NDDs) are characterized by the progressive degeneration and/or loss of neurons belonging to the central nervous system, and represent one of the major global health issues. Therefore, a number of immunotherapeutic approaches targeting the non-functional or toxic proteins that induce neurodegeneration in NDDs have been designed in the last decades. In this context, due to unprecedented advances in genetic engineering techniques and molecular farming technology, pioneering plant-based immunogenic antigen expression systems have been developed aiming to offer reliable

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Shubham, Mane Vidya Kale. "A Review on Novel Drug Delivery System." International Journal of Pharmaceutical Sciences 2, no. 6 (2024): 1099–111. https://doi.org/10.5281/zenodo.12491082.

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Quest for Novel Drug Delivery System (NDDS) has started since long back, but it has got momentum since last few decades. NDDS has several advantages over the conventional dosage form which includes better therapeutic outcome. NDDS is also preferred in the new patent regimen as this is one of the ways to introduce new products in the regulated market. Several types of NDDS have been developed during last few decades which are- Microparticles, Nanoparticles, Osmotically Modulated Drug Delivery Systems, Transdermal Therapeutic Systems (TTS), Aquasome, Dendrimers, Multiple Emulsions, Microemulsion

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Gupta, Swapnil, Panpan You, Tanima SenGupta, Hilde Nilsen, and Kulbhushan Sharma. "Crosstalk between Different DNA Repair Pathways Contributes to Neurodegenerative Diseases." Biology 10, no. 2 (2021): 163. http://dx.doi.org/10.3390/biology10020163.

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Genomic integrity is maintained by DNA repair and the DNA damage response (DDR). Defects in certain DNA repair genes give rise to many rare progressive neurodegenerative diseases (NDDs), such as ocular motor ataxia, Huntington disease (HD), and spinocerebellar ataxias (SCA). Dysregulation or dysfunction of DDR is also proposed to contribute to more common NDDs, such as Parkinson’s disease (PD), Alzheimer’s disease (AD), and Amyotrophic Lateral Sclerosis (ALS). Here, we present mechanisms that link DDR with neurodegeneration in rare NDDs caused by defects in the DDR and discuss the relevance fo

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Sanghai, Nitesh, and Geoffrey K. Tranmer. "Biochemical and Molecular Pathways in Neurodegenerative Diseases: An Integrated View." Cells 12, no. 18 (2023): 2318. http://dx.doi.org/10.3390/cells12182318.

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Neurodegenerative diseases (NDDs) like Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS) are defined by a myriad of complex aetiologies. Understanding the common biochemical molecular pathologies among NDDs gives an opportunity to decipher the overlapping and numerous cross-talk mechanisms of neurodegeneration. Numerous interrelated pathways lead to the progression of neurodegeneration. We present evidence from the past pieces of literature for the most usual global convergent hallmarks like ageing, oxidative stress, excitotoxicity-induced calcium butt

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Gulati, Sheffali. "Neurodevelopmental Disorders: The Journey, the Dreams and their Realization." Annals of the National Academy of Medical Sciences (India) 53, no. 01 (2017): 030–35. http://dx.doi.org/10.1055/s-0040-1712742.

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ABSTRACTNeuro Developmental Disorders (NDDs) are associated with signiﬁcant morbidity. This involves early identiﬁcation of the disorder, the correct management of the disorder and associated disabilities. In India, the paucity of trained personnel and lack of knowledge about these disorders has been instrumental in inadequate management and recognition of these NDDs. The Child Neurology Division, Department of Pediatrics at All India Institute of Medical Sciences has made few noteworthy and meaningful contributions in these aspects: devising a DM curriculum for pediatric neurology, developing

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Bayazid, Al Borhan, and Beong Ou Lim. "Quercetin Is An Active Agent in Berries against Neurodegenerative Diseases Progression through Modulation of Nrf2/HO1." Nutrients 14, no. 23 (2022): 5132. http://dx.doi.org/10.3390/nu14235132.

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Berries are well-known fruits for their antioxidant effects due to their high content of flavonoids, and quercetin is one of the potent bioactive flavonoids. Although oxidative stress is an inevitable outcome in cells due to energy uptake and metabolism and other factors, excessive oxidative stress is considered a pivotal mediator for the cell death and leads to the progression of neurodegenerative diseases (NDDs). Furthermore, oxidative stress triggers inflammation that leads to neuronal cell loss. Alzheimer’s, Parkinson’s, Huntington’s disease, amyotrophic lateral sclerosis, multiple scleros

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Ashwin, JV, Astha Singh, Mohit Kumar Shahi, Bhupendra Singh, and Rama Appala Narasimha Reddy Challa. "Prevalence of bruxism in neurodegenerative disorders in the elderly: A systematic review and meta-analysis." Industrial Psychiatry Journal 34, no. 1 (2025): 4–10. https://doi.org/10.4103/ipj.ipj_152_24.

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Bruxism, characterized by the rhythmic grinding and clenching of teeth, is a common parafunctional behavior with implications beyond oral health. Recent interest has emerged in exploring its association with neurodegenerative disorders (NDDs), such as Parkinson’s disease (PD), Alzheimer’s disease (AD), and frontotemporal dementia (FTD). This systematic review and meta-analysis aimed to investigate the prevalence of bruxism in individuals with NDDs, synthesizing existing evidence and identifying areas for further investigation. A comprehensive search strategy was implemented across electronic d

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Gunaseelan, Vinusha, Patricia Parkin, Imaan Bayoumi, et al. "EVALUATING THE PREDICTIVE VALIDITY OF THE NIPISSING DISTRICT DEVELOPMENTAL SCREEN IN PRIMARY CARE SETTINGS AT THE 18-MONTH HEALTH SUPERVISION VISIT." Paediatrics & Child Health 23, suppl_1 (2018): e37-e37. http://dx.doi.org/10.1093/pch/pxy054.096.

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Abstract BACKGROUND The Canadian Paediatric Society (CPS) recommends that every Canadian physician caring for young children provide an enhanced 18-month well-baby visit including the use of a developmental screening tool, such as the Nipissing District Developmental Screen (NDDS). The Province of Ontario implemented an enhanced 18-month well-baby visit specifically emphasizing the NDDS, which is now widely used in Ontario primary care. However, the diagnostic accuracy of the NDDS in identifying early developmental delays in real-world clinical settings is unknown. OBJECTIVES To assess the pre

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Ozlu, Can, Rachel M. Bailey, Sarah Sinnett, and Kimberly D. Goodspeed. "Gene Transfer Therapy for Neurodevelopmental Disorders." Developmental Neuroscience 43, no. 3-4 (2021): 230–40. http://dx.doi.org/10.1159/000515434.

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Neurodevelopmental disorders (NDDs) include a broad spectrum of disorders that disrupt normal brain development. Though some NDDs are caused by acquired insults (i.e., toxic or infectious encephalopathy) or may be cryptogenic, many NDDs are caused by variants in a single gene or groups of genes that disrupt neuronal development or function. In this review, we will focus on those NDDs with a genetic etiology. The exact mechanism, timing, and progression of the molecular pathology are seldom well known; however, the abnormalities in development typically manifest in similar patterns such as dela

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R Senthil Prabhu. "Advances in NDDS: An expansive menu of choices in the management of pandemic." International Journal of Frontiers in Biology and Pharmacy Research 2, no. 2 (2022): 001–6. http://dx.doi.org/10.53294/ijfbpr.2022.2.2.0031.

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Novel Drug Delivery System (NDDS) is a novel approach to deliver the drug that addresses the limitations of the traditional drug delivery systems with enhanced patient care and site specific drug delivery. Besides several NDDS are currently used for treating Coronavirus disease (COVID-19), nanovaccines, liposomes and nanoparticles are gaining more interest towards research and manufacturing in pharmaceutical industry. COVID-19 is an infectious disease caused by the SARS-CoV-2 virus. It has found its roots from China and has declared as a pandemic all over the world by World Health Organization

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Xu, Rongmei, Qiaoju Kang, Xuefei Yang, Ping Yi, and Rongying Zhang. "Unraveling Molecular Targets for Neurodegenerative Diseases Through Caenorhabditis elegans Models." International Journal of Molecular Sciences 26, no. 7 (2025): 3030. https://doi.org/10.3390/ijms26073030.

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Neurodegenerative diseases (NDDs), including Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), and prion disease, represent a group of age-related disorders that pose a growing and formidable challenge to global health. Despite decades of extensive research that has uncovered key genetic factors and biochemical pathways, the precise molecular mechanisms underlying these diseases and effective therapeutic strategies remain elusive. Caenorhabditis elegans (C. elegans) has emerged as a powerful model organism for studying NDDs due

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Ayeni, Emmanuel A., Ahmad M. Aldossary, Daniel A. Ayejoto, et al. "Neurodegenerative Diseases: Implications of Environmental and Climatic Influences on Neurotransmitters and Neuronal Hormones Activities." International Journal of Environmental Research and Public Health 19, no. 19 (2022): 12495. http://dx.doi.org/10.3390/ijerph191912495.

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Neurodegenerative and neuronal-related diseases are major public health concerns. Human vulnerability to neurodegenerative diseases (NDDs) increases with age. Neuronal hormones and neurotransmitters are major determinant factors regulating brain structure and functions. The implications of environmental and climatic changes emerged recently as influence factors on numerous diseases. However, the complex interaction of neurotransmitters and neuronal hormones and their depletion under environmental and climatic influences on NDDs are not well established in the literature. In this review, we aim

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Todinova, Svetla, Sashka Krumova, Desislava Bogdanova, et al. "Red Blood Cells’ Thermodynamic Behavior in Neurodegenerative Pathologies and Aging." Biomolecules 11, no. 10 (2021): 1500. http://dx.doi.org/10.3390/biom11101500.

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The main trend of current research in neurodegenerative diseases (NDDs) is directed towards the discovery of novel biomarkers for disease diagnostics and progression. The pathological features of NDDs suggest that diagnostic markers can be found in peripheral fluids and cells. Herein, we investigated the thermodynamic behavior of the peripheral red blood cells (RBCs) derived from patients diagnosed with three common NDDs—Parkinson’s disease (PD), Alzheimer’s disease (AD), and amyotrophic lateral sclerosis (ALS) and compared it with that of healthy individuals, evaluating both fresh and aged RB

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Seigfried, Franziska Anna, and Stefan Britsch. "The Role of Bcl11 Transcription Factors in Neurodevelopmental Disorders." Biology 13, no. 2 (2024): 126. http://dx.doi.org/10.3390/biology13020126.

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Neurodevelopmental disorders (NDDs) comprise a diverse group of diseases, including developmental delay, autism spectrum disorder (ASD), intellectual disability (ID), and attention-deficit/hyperactivity disorder (ADHD). NDDs are caused by aberrant brain development due to genetic and environmental factors. To establish specific and curative therapeutic approaches, it is indispensable to gain precise mechanistic insight into the cellular and molecular pathogenesis of NDDs. Mutations of BCL11A and BCL11B, two closely related, ultra-conserved zinc-finger transcription factors, were recently repor

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Onyango, Silas, Margaret Nampijja, Paul Otwate, et al. "Nurturing care practices for children with developmental disabilities in sub-Saharan Africa: A scoping review protocol." PLOS ONE 19, no. 5 (2024): e0291839. http://dx.doi.org/10.1371/journal.pone.0291839.

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Background The majority of children with neurodevelopmental disorders (NDDs) reside in low- and middle-income countries (LMICs). NDDs are a public health concern in countries in sub-Saharan Africa (SSA). Nurturing care has been recommended as a pathway for addressing the developmental needs and unlocking the full potential of children, including those with NDDs. However, little information exists on the strategies to support children with NDDs using the Nurturing Care Framework in many countries in SSA. This review aims to synthesize information on nurturing care practices for children with ND

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Zhang, Yi, Tao Wang, Yan Wang, Kun Xia, Jinchen Li, and Zhongsheng Sun. "Targeted sequencing and integrative analysis to prioritize candidate genes in neurodevelopmental disorders." Molecular Neurobiology 58, no. 8 (2021): 3863–73. http://dx.doi.org/10.1007/s12035-021-02377-y.

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AbstractNeurodevelopmental disorders (NDDs) are a group of diseases characterized by high heterogeneity and frequently co-occurring symptoms. The mutational spectrum in patients with NDDs is largely incomplete. Here, we sequenced 547 genes from 1102 patients with NDDs and validated 1271 potential functional variants, including 108 de novo variants (DNVs) in 78 autosomal genes and seven inherited hemizygous variants in six X chromosomal genes. Notably, 36 of these 78 genes are the first to be reported in Chinese patients with NDDs. By integrating our genetic data with public data, we prioritize

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Miteva, Dimitrina, Georgi V. Vasilev, and Tsvetelina Velikova. "Role of Specific Autoantibodies in Neurodegenerative Diseases: Pathogenic Antibodies or Promising Biomarkers for Diagnosis." Antibodies 12, no. 4 (2023): 81. http://dx.doi.org/10.3390/antib12040081.

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Neurodegenerative diseases (NDDs) affect millions of people worldwide. They develop due to the pathological accumulation and aggregation of various misfolded proteins, axonal and synaptic loss and dysfunction, inflammation, cytoskeletal abnormalities, defects in DNA and RNA, and neuronal death. This leads to the activation of immune responses and the release of the antibodies against them. Recently, it has become clear that autoantibodies (Aabs) can contribute to demyelination, axonal loss, and brain and cognitive dysfunction. This has significantly changed the understanding of the participati

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Fakhri, Sajad, Mohammad Mehdi Gravandi, Sadaf Abdian, Esra Küpeli Akkol, Mohammad Hosein Farzaei, and Eduardo Sobarzo-Sánchez. "The Neuroprotective Role of Polydatin: Neuropharmacological Mechanisms, Molecular Targets, Therapeutic Potentials, and Clinical Perspective." Molecules 26, no. 19 (2021): 5985. http://dx.doi.org/10.3390/molecules26195985.

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Neurodegenerative diseases (NDDs) are one of the leading causes of death and disability in humans. From a mechanistic perspective, the complexity of pathophysiological mechanisms contributes to NDDs. Therefore, there is an urgency to provide novel multi-target agents towards the simultaneous modulation of dysregulated pathways against NDDs. Besides, their lack of effectiveness and associated side effects have contributed to the lack of conventional therapies as suitable therapeutic agents. Prevailing reports have introduced plant secondary metabolites as promising multi-target agents in combat

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Dominguez, Gaea, Yongji Wu, and Jian Zhou. "Epigenetic Regulation and Neurodevelopmental Disorders: From MeCP2 to the TCF20/PHF14 Complex." Genes 15, no. 12 (2024): 1653. https://doi.org/10.3390/genes15121653.

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Background: Neurodevelopmental disorders (NDDs) affect approximately 15% of children and adolescents worldwide. This group of disorders is often polygenic with varying risk factors, with many associated genes converging on shared molecular pathways, including chromatin regulation and transcriptional control. Understanding how NDD-associated chromatin regulators and protein complexes orchestrate these regulatory pathways is crucial for elucidating NDD pathogenesis and developing targeted therapeutic strategies. Recently, the TCF20/PHF14 chromatin complex was identified in the mammalian brain, e

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Firdaus, Zeba, and Xiaogang Li. "Unraveling the Genetic Landscape of Neurological Disorders: Insights into Pathogenesis, Techniques for Variant Identification, and Therapeutic Approaches." International Journal of Molecular Sciences 25, no. 4 (2024): 2320. http://dx.doi.org/10.3390/ijms25042320.

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Genetic abnormalities play a crucial role in the development of neurodegenerative disorders (NDDs). Genetic exploration has indeed contributed to unraveling the molecular complexities responsible for the etiology and progression of various NDDs. The intricate nature of rare and common variants in NDDs contributes to a limited understanding of the genetic risk factors associated with them. Advancements in next-generation sequencing have made whole-genome sequencing and whole-exome sequencing possible, allowing the identification of rare variants with substantial effects, and improving the under

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Wang, Jing, Xueying Yan, Wenfei Wang, et al. "Rab21-Targeted Nano Drug Delivery System-Based FFPG for Efficient Paclitaxel Delivery to Inhibit Lung Cancer Progression." Pharmaceutics 17, no. 1 (2025): 94. https://doi.org/10.3390/pharmaceutics17010094.

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Background/Objectives: Platycodon grandiflorus (PG) has been widely researched as a conductant drug for the treatment of lung diseases by ancient and modern traditional Chinese medicine (TCM) practitioners. Inspired by the mechanism and our previous finding about fructans and fructooligosaccharides from Platycodon grandiflorus (FFPG), we developed a nano drug delivery system (NDDS) targeting lung cancer. The aim was to improve the efficiency of the liposomal delivery of Paclitaxel (PTX) and enhance the anti-tumor efficacy. Methods: The FFPG-Lip-PTX NDDS was prepared by electrostatic adsorption

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Liu, Jingjing, Xinye Qi, Rizhen Wang, et al. "The Physical Developmental Characterization of Children with Nutritional Deficiencies and Attributed Specific Categories." Nutrients 17, no. 1 (2024): 86. https://doi.org/10.3390/nu17010086.

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Background: There are few studies examining the physical developmental phenotypes of nutritional deficiency diseases (NDDs) among Chinese children aged 1–7 years by anthropometrics and clarifying the specific NDD categories that caused growth faltering. Methods: A total of 3054 cases of NDDs in children aged 1–7 years were investigated. The age, height, and weight of children with NDDs were adjusted by using the skewness coefficient–median–coefficient of variation method, and the results were compared with the WHO standardized level. Comparisons of specific categories of NDDs were performed wi

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Lee, Ga Young, Kyeong Sun Cha, Chan Yoon Park, Seung Eun Lee, Mun Kyong Pae, and Sung Nim Han. "Differential Effect of Vitamin D Supplementation on Natural Killer Cell Activity in Normal and Obese Mice." FASEB Journal 31, S1 (2017). http://dx.doi.org/10.1096/fasebj.31.1_supplement.964.9.

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Vitamin D has an immunomodulatory effect on both innate and adaptive immune responses. Vitamin D has been reported to induce differentiation of monocytes into macrophages, inhibit maturation and differentiation of dendritic cells, and suppress adaptive immunity. Although there are some in vitro studies which showed that vitamin D suppressed Natural Killer (NK) cell activity and IFN‐γ secretion, little is known about the in vivo effect of vitamin D on NK cell functions. In this study, we investigated the in vivo effect of vitamin D on NK cell functions by measuring NK activity, cytokine secreti

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Shao, Xiaotong, Changkuo Shi, Shuqing Wu, Fei Wang, and Wenliang Li. "Review of the pharmacokinetics of nanodrugs." Nanotechnology Reviews 12, no. 1 (2023). http://dx.doi.org/10.1515/ntrev-2022-0525.

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Abstract Nanodrug delivery systems (NDDSs) are a hotspot of new drug delivery systems with great development potential. They provide new approaches to fighting against diseases. NDDSs are specially designed to serve as carriers for the delivery of active pharmaceutical ingredients to their target sites, and their unique physicochemical characteristics allow for prolonged circulation time, improved targeting, and avoidance of drug resistance. Despite remarkable progress achieved in the preparation and efficacy evaluation of NDDSs, the understanding of the in vivo pharmacokinetics of NDDSs is st

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Tal-Saban, Miri, Shahar Zaguri-Vittenberg, and Yonat Ivzori. "Enhancing Occupational Therapists’ Intervention Capabilities With Adolescents With Neurodevelopmental Disorders." Canadian Journal of Occupational Therapy, August 9, 2024. http://dx.doi.org/10.1177/00084174241272010.

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Background. Adolescents with neurodevelopmental disorders (NDDs) have an increased risk of participation limitations. Occupational therapy faces knowledge-to-practice gaps among this population. Purpose. To examine the effectiveness of a continuing-education program for occupational therapists working with adolescents with NDDs. Methods. The study used a mixed-method design, including pre–post comparisons of competence and sense of self-efficacy of occupational therapists to work with adolescents with NDDs. Interviews regarding the program's perceived contribution to practice were conducted. R

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Ye, Qiuyan, Xue Li, Wei Gao, et al. "Role of Rho-associated kinases and their inhibitor fasudil in neurodegenerative diseases." Frontiers in Neuroscience 18 (November 19, 2024). http://dx.doi.org/10.3389/fnins.2024.1481983.

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Neurodegenerative diseases (NDDs) are prevalent in the elderly. The pathogenesis of NDDs is complex, and currently, there is no cure available. With the increase in aging population, over 20 million people are affected by common NDDs alone (Alzheimer’s disease and Parkinson’s disease). Therefore, NDDs have profound negative impacts on patients, their families, and society, making them a major global health concern. Rho-associated kinases (ROCKs) belong to the serine/threonine protein kinases family, which modulate diverse cellular processes (e.g., apoptosis). ROCKs may elevate the risk of vari

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