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Journal articles on the topic 'NDM-Kp'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

Dobreva, Elina, Ivan Ivanov, Deyan Donchev, et al. "In vitro Investigation of Antibiotic Combinations against Multi- and Extensively Drug-Resistant Klebsiella pneumoniae." Open Access Macedonian Journal of Medical Sciences 10, B (2022): 1308–14. http://dx.doi.org/10.3889/oamjms.2022.8934.

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Objectives: Community and hospital acquired K. pneumoniae infections have become a ubiquitous medical issue due to the limited treatment options and high mortality rate therefore the aims of this study are in vitro investigation of double antimicrobial combinations against multidrug resistant (MDR) and extensively drug resistant (XDR) isolates. Materials and Methods: Antimicrobial susceptibility of twelve isolates from eight Bulgarian hospitals was determined to study the interaction effect of selected double combinations in accordance to fractional inhibitory concentration (FIC) method.

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2

Hernández-García, Marta, Blanca Pérez-Viso, Ricardo León-Sampedro, et al. "Outbreak of NDM-1+CTX-M-15+DHA-1-producing Klebsiella pneumoniae high-risk clone in Spain owing to an undetectable colonised patient from Pakistan." International Journal of Antimicrobial Agents 54 (May 21, 2019): 233–39. https://doi.org/10.1016/j.ijantimicag.2019.05.021.

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Description of an outbreak due to NDM-1 + CTX-M-15 + DHA-1-producing Klebsiella pneumoniae (NDM- 1-Kp) in Spain related to a patient previously admitted to a healthcare centre in an endemic area (Pakistan).

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Belati, Alessandra, Davide Fiore Bavaro, Lucia Diella, Nicolò De Gennaro, Francesco Di Gennaro, and Annalisa Saracino. "Meropenem/Vaborbactam Plus Aztreonam as a Possible Treatment Strategy for Bloodstream Infections Caused by Ceftazidime/Avibactam-Resistant Klebsiella pneumoniae: A Retrospective Case Series and Literature Review." Antibiotics 11, no. 3 (2022): 373. http://dx.doi.org/10.3390/antibiotics11030373.

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Objectives: The aim of this study was to describe our experience of a combination treatment including meropenem/vaborbactam (M/V) plus aztreonam (ATM) for bloodstream infections (BSIs) due to ceftazidime/avibactam-resistant Klebsiella pneumoniae (CAZ/AVI-R-Kp), for which gene typing was not available at the time the blood culture (BC) results were obtained. Methods: Between 20 July and 22 August 2021, in our hospital laboratory, the molecular test for carbapenemase gene typing was not available. All Gram-negative bloodstream infections were recorded, and characteristics of patients were analys

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Wysocka, Magdalena, Roxana Zamudio, Marco R. Oggioni, Justyna Gołębiewska, Marek Bronk, and Beata Krawczyk. "Genetic Background and Antibiotic Resistance Profiles of K. pneumoniae NDM-1 Strains Isolated from UTI, ABU, and the GI Tract, from One Hospital in Poland, in Relation to Strains Nationally and Worldwide." Genes 12, no. 8 (2021): 1285. http://dx.doi.org/10.3390/genes12081285.

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In recent years, there has been an observed increase in infections caused by carbapenem-resistant Klebsiella pneumonia (Kp) strains. The aim of this study was the phenotypic and genotypic analysis of eight K. pneumoniae NDM (Kp NDM) isolates, recovered in Poland during the years 2016 and 2018 from seven patients with urinary tract infections (UTIs), asymptomatic bacteriuria (ABU), or colonization of the gut. PCR melting profile genotyping indicated a close relationship between the strains derived from 2018, which were not related to the strain isolated in 2016. WGS results were analyzed in rel

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Tocco Tussardi, Ilaria, Gloria Stevanin, Livio Montesarchio, et al. "Rapid Response and Containment of an NDM-Producing Klebsiella Pneumoniae Outbreak in a Hematology Ward: Case Study from an Italian Hospital." Healthcare 13, no. 12 (2025): 1457. https://doi.org/10.3390/healthcare13121457.

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Antimicrobial resistance (AMR) constitutes a critical threat to global public health, with carbapenem-resistant Enterobacterales (CRE) presenting significant challenges due to their resistance to last-line antibiotics. Among these, New Delhi metallo-beta-lactamase (NDM)-producing Klebsiella pneumoniae (KP) is of particular concern. This study describes an outbreak of NDM-producing KP in the hematology unit of the University Hospital of Verona, Italy. This represents the second reported hospital outbreak of this strain in Italy, and the first to occur within a hematology ward. The outbreak invo

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Gopinath, Ramya, Patrice Savard, Karen C. Carroll, Lucy E. Wilson, B. Mark Landrum та Trish M. Perl. "Infection Prevention Considerations Related to New Delhi Metallo-β-Lactamase Enterobacteriaceae A Case Report". Infection Control & Hospital Epidemiology 34, № 1 (2013): 99–100. http://dx.doi.org/10.1086/668782.

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A 60-year-old American man who was hospitalized in India for 4 weeks after an intracranial bleed was transferred by air ambulance to a 249-bed community hospital in Maryland in January 2011. His clinical course is described elsewhere. Here, we describe the infection prevention considerations surrounding his care in the hospital. A sputum sample obtained from the patient grew a New Delhi metallo-β-lactamase-producing (NDM) Klebsiella pneumoniae (NDM-KP) strain and panresistant Acinetobacter species, among other pathogens. Two weeks later, a perirectal swab sample grew an NDM-1 Salmonella Senfte

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Qamar, Muhammad Usman, Hasan Ejaz, Timothy R. Walsh та ін. "Clonal relatedness and plasmid profiling of extensively drug-resistant New Delhi metallo-β-lactamase-producing Klebsiella pneumoniae clinical isolates". Future Microbiology 16, № 4 (2021): 229–39. http://dx.doi.org/10.2217/fmb-2020-0315.

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Aim: Carbapenem-resistant Klebsiella pneumoniae (CR-KP) particularly New Delhi metallo-β-lactamase (NDM) is a serious public health concern globally. The aim of the study to determine the molecular epidemiology of blaNDM-producing clinically isolated K. pneumoniae. Methods: Carbapenem-resistant K. pneumoniae isolates (n = 100) were collected from tertiary care hospital Lahore. Isolates were confirmed by VITEK® 2 system and MALDI-TOF. Minimum inhibitory concentration was performed by VITEK 2 and molecular characterization was done by PCR, PFGE, DNA hybridization and replicon typing. Results: Of

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Oliveira, Pâmela Maria, Célio Faria-Junior, Daniely Martins Silva, Larissa Fernandes Matos, and Alex Leite Pereira. "Clonal complexes of carbapenem-resistant Klebsiella pneumoniae recovered from community sewage." Journal of Water and Health 21, no. 1 (2023): 94–108. http://dx.doi.org/10.2166/wh.2023.237.

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Abstract Carbapenem-resistant Klebsiella pneumoniae (CR-Kp) are life-threatening multidrug-resistant bacteria. In this study, CR-Kp strains isolated from sewage treatment plants (STPs) (n = 12) were tested for carbapenemase genes (blaKPC, blaNDM, blaIMP, blaVIM and blaOXA-48) and had their sequence types (ST) and clonal complexes (CCs) defined. A collection of clinical CR-Kp strains recovered in local hospitals was added to phylogenetic analyses along with sewage strains in order to infer clonality among CR-Kp strains. A total of 154 CR-Kp strains were isolated from raw sewage [55.8% (86/154)]

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Pons, Maria J., Marta Marí-Almirall, Barbara Ymaña, et al. "Spread of ST348 Klebsiella pneumoniae Producing NDM-1 in a Peruvian Hospital." Microorganisms 8, no. 9 (2020): 1392. http://dx.doi.org/10.3390/microorganisms8091392.

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The aim of this study was to characterize carbapenem-resistant Klebsiella pneumoniae (CR-Kp) isolates recovered from adults and children with severe bacteremia in a Peruvian Hospital in June 2018. Antimicrobial susceptibility was determined by disc/gradient diffusion and broth microdilution when necessary. Antibiotic resistance mechanisms were evaluated by PCR and DNA sequencing. Clonal relatedness was assessed using pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). Plasmid typing was performed with a PCR-based method. Thirty CR-Kp isolates were recovered in June 2

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Novikova, I. E., Z. Z. Sadeeva, E. A. Samoylova, O. V. Karaseva, O. G. Yanyushkina та A. V. Lazareva. "Сharacterization of Klebsiella pneumoniae paired strains isolated from pediatric patients". Clinical Microbiology and Antimicrobial Chemotherapy 26, № 4 (2024): 496–504. https://doi.org/10.36488/cmac.2024.4.496-504.

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Objective. To analyze and compare multidrug-resistant Klebsiella pneumoniae (KP) strains isolated from different sites of the same patients. Materials and Methods. A total of 30 KP strains isolated from 15 patients treated in intensive care and surgical units in 2020–2021 were studied. Two strains isolated from one child were selected for analyses. One strain was isolated from a clinically significant site (blood/urine/wound/endotracheal aspirate or sputum), the other from a monitoring site (stool). Antibiotic susceptibility was determined using the broth microdilution method. The presence of

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Taing, Meng-Wong, Jean-Thomas Pierson, Paul N. Shaw, et al. "Mango Fruit Extracts Differentially Affect Proliferation and Intracellular Calcium Signalling in MCF-7 Human Breast Cancer Cells." Journal of Chemistry 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/613268.

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The assessment of human cancer cell proliferation is a common approach in identifying plant extracts that have potential bioactive effects. In this study, we tested the hypothesis that methanolic extracts of peel and flesh from three archetypal mango cultivars, Irwin (IW), Nam Doc Mai (NDM), and Kensington Pride (KP), differentially affect proliferation, extracellular signal-regulated kinase (ERK) activity, and intracellular calcium ([Ca2+]I) signalling in MCF-7 human breast cancer cells. Mango flesh extracts from all three cultivars did not inhibit cell growth, and of the peel extracts only N

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Cismaru, Ioana Miriana, Maria Cristina Văcăroiu, Elif Soium, et al. "Synergistic Combination of Aztreonam and Ceftazidime–Avibactam—A Promising Defense Strategy against OXA-48 + NDM Klebsiella pneumoniae in Romania." Antibiotics 13, no. 6 (2024): 550. http://dx.doi.org/10.3390/antibiotics13060550.

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With the increasing burden of carbapenem-resistant Klebsiella pneumoniae (CR-Kp), including high rates of healthcare-associated infections, treatment failure, and mortality, a good therapeutic strategy for attacking this multi-resistant pathogen is one of the main goals in current medical practice and necessitates the use of novel antibiotics or new drug combinations. Objectives: We reviewed the clinical and microbiological outcomes of seven patients treated at the “Agrippa Ionescu” Clinical Emergency Hospital between October 2023 and January 2024, aiming to demonstrate the synergistic activit

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Krapp, Fiorella, Catherine Amaro, Karen Ocampo, et al. "1189. A Comprehensive Characterization of the Emerging Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates From a Public Hospital in Lima, Peru." Open Forum Infectious Diseases 5, suppl_1 (2018): S359—S360. http://dx.doi.org/10.1093/ofid/ofy210.1022.

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Abstract Background In contrast with other countries in Latin America, Peru had been notoriously spared by the global dissemination of carbapenem-resistant Klebsiella pneumoniae (CR-Kp), until recently. Even though, isolated cases of KPC-producing K. pneumoniae had been reported since 2013, it was not until 2016 that the first outbreak of NDM- producing K. pneumoniae was described in Peru. By 2017, rapid emergence of CR-Kp took place in Hospital Cayetano Heredia (HCH), a tertiary care hospital in Lima. Here, we provide a description of clinical, microbiological and molecular characteristics of

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Jaisal, Shashikant, Amit Singh, Rajesh K. Verma, et al. "Evaluation of biofilm formation and carbapenem resistance in Klebsiella pneumoniae isolated from clinical samples at a rural hospital in western Uttar Pradesh." Journal of Family Medicine and Primary Care 13, no. 11 (2024): 4894–900. http://dx.doi.org/10.4103/jfmpc.jfmpc_1178_23.

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ABSTRACT Introduction: Klebsiella pneumoniae commonly causes healthcare-associated infections and shows multidrug resistance. K. pneumoniae can produce biofilm. Carbapenem resistance in K. pneumoniae is due to the production of carbapenemases mainly. This study was done to evaluate the formation of biofilm and carbapenemase resistance in K. pneumoniae isolates. Material and Methods: A total of 110 K. pneumoniae isolated from various clinical samples were taken, the antibiotic susceptibility test was done by the Kirby disk diffusion method, and biofilm detection was done by the tissue culture p

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Khan, Ayesha, Blake Hanson, An Dinh, et al. "705. Four Superbugs Isolated From a Single Patient in the United States: E. coli (EC) and K. pneumoniae (KP) Harboring NDM-5, P. aeruginosa (PA) Harboring NDM-1 and Candida auris." Open Forum Infectious Diseases 5, suppl_1 (2018): S254. http://dx.doi.org/10.1093/ofid/ofy210.712.

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Abstract Background The spread of carbapenem resistance in Enterobacteriacae (CRE) and PA is an urgent public health concern. Candida auris (CA) is also an emerging threat, with the epicenter of US cases on the East Coast. Transcontinental spread of multi-drug-resistant (MDR) organisms has the potential to change local susceptibility patterns via dissemination of resistance determinants or high-risk clones. Here, we report and characterize MDR-isolates of EC, KP, PA and CA, all isolated from a single patient admitted to an ICU in Houston, Texas after complications from plastic surgery in India

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Liu, Shuli, Xiaobo Wang, Jingjing Ge, et al. "Analysis of Carbapenemase-Resistant Genotypes of Highly Virulent Klebsiella pneumoniae and Clinical Infection Characteristics of Different MLST Types." Evidence-Based Complementary and Alternative Medicine 2021 (September 30, 2021): 1–9. http://dx.doi.org/10.1155/2021/3455121.

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Carbapenemase-resistant Klebsiella pneumoniae (CR-KP) has become one of the nosocomial infections that seriously threaten the lives of patients, greatly increasing the burden on patients. In order to explore the resistance mechanism of clinically isolated CR-KP to carbapenems and perform multilocus sequence typing (MLST), to study the clinical characteristics of patients with different ST types of infection, we collected 74 CR-KP strains clinically isolated from the main 6 hospitals in Zhejiang province from January 2018 to July 2020. The sensitivity of the tested strains to 23 antibacterial d

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Ocampo, Ana M., Liang Chen, Astrid V. Cienfuegos, et al. "A Two-Year Surveillance in Five Colombian Tertiary Care Hospitals Reveals High Frequency of Non-CG258 Clones of Carbapenem-Resistant Klebsiella pneumoniae with Distinct Clinical Characteristics." Antimicrobial Agents and Chemotherapy 60, no. 1 (2015): 332–42. http://dx.doi.org/10.1128/aac.01775-15.

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ABSTRACTThe global spread of carbapenem-resistantKlebsiella pneumoniae(CR-Kp) has been largely associated with sequence type 258 (ST258) and its related variants (clonal group 258 [CG258]). Here we describe the molecular epidemiology of CR-Kp from five tertiary care hospitals in Medellín, the second largest city in Colombia. All CR-Kp-infected patients admitted from June 2012 to June 2014 were included (n= 193). Patients' clinical information was obtained from medical records. Carbapenemase KPC, VIM, IMP, NDM, and OXA-48 genes were detected by PCR. A CG258-tonB79cluster-specific real-time PCR

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Tängdén, T., R. A. Hickman, P. Forsberg, P. Lagerbäck, C. G. Giske, and O. Cars. "Evaluation of Double- and Triple-Antibiotic Combinations for VIM- and NDM-Producing Klebsiella pneumoniae byIn VitroTime-Kill Experiments." Antimicrobial Agents and Chemotherapy 58, no. 3 (2014): 1757–62. http://dx.doi.org/10.1128/aac.00741-13.

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ABSTRACTCombination therapy is recommended for infections with carbapenemase-producingKlebsiella pneumoniae. However, limited data exist on which antibiotic combinations are the most effective. The aim of this study was to find effective antibiotic combinations against metallo-beta-lactamase-producingK. pneumoniae(MBL-KP). Two VIM- and two NDM-producingK. pneumoniaestrains, all susceptible to colistin, were exposed to antibiotics at clinically relevant static concentrations during 24-h time-kill experiments. Double- and triple-antibiotic combinations of aztreonam, ciprofloxacin, colistin, dapt

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Avery, Lindsay M., Salvador Vernacchio, Lisa McLaughlin, Luigi Xerri, Greg Moeck та Daniel Pevear. "1263. Assessment of Cefepime (FEP)-Taniborbactam (TAN) Human Exposures to Suppress the Emergence of Resistance among Serine (SBL)- and Metallo-β-Lactamase (MBL)-Producing Gram-Negative Bacteria (GNB) in a Hollow Fiber Infection Model (HFIM)". Open Forum Infectious Diseases 7, Supplement_1 (2020): S648. http://dx.doi.org/10.1093/ofid/ofaa439.1447.

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Abstract Background FEP-TAN (FTB) efficacy and safety are currently being evaluated in a Phase 3 trial (NCT03840148). TAN, a boronic acid-based β-lactamase inhibitor, restores susceptibility to FEP when resistance is driven by SBL or MBL (ie, NDM, VIM). This in vitro study assessed whether clinical FTB exposures suppress treatment-emergent resistance in pathogenic Enterobacterales and Pseudomonas aeruginosa. Methods Bioreactors (C2011, FiberCell) were inoculated with clinical GNB strains (N=6) using highly concentrated log phase cultures (&gt; 108 CFU). Syringe pumps supplied humanized exp

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Li, Bin, Xiao-hong Xu, Zhi-chang Zhao, Mei-hua Wang та Ying-ping Cao. "High prevalence of metallo-β-lactamase among carbapenem-resistant Klebsiella pneumoniae in a teaching hospital in China". Canadian Journal of Microbiology 60, № 10 (2014): 691–95. http://dx.doi.org/10.1139/cjm-2014-0291.

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The aim of this study was to characterize the carbapenemases in carbapenem-resistant Klebsiella pneumoniae (CR-KP) from a Chinese teaching hospital. A total of 40 CR-KPs were screened for the presence of carbapenemases. Minimum inhibitory concentrations were determined by agar dilution. The modified Hodge test was used for the detection of carbapenemase production. Carbapenemase, extended-spectrum β-lactamase, and AmpC genes were detected using polymerase chain reaction (PCR) and sequencing. A conjugation test was performed using a broth culture mating method, transferred plasmids were typed b

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Critchley, Ian A., Nicole Cotroneo, Rodrigo E. Mendes, and Michael J. Pucci. "1226. In Vitro Activity of Tebipenem and Comparators Against Enterobacterales Collected from Patients with Bloodstream Infections as Part of the 2019 Global STEWARD Surveillance Program." Open Forum Infectious Diseases 8, Supplement_1 (2021): S702. http://dx.doi.org/10.1093/ofid/ofab466.1418.

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Abstract Background Bloodstream infections (BSI) are a significant cause of morbidity and mortality. Enterobacterales (ENT) are frequently implicated in BSI with an increase in organisms producing extended-spectrum β-lactamase (ESBL). This challenges a possible transition to current oral agents due to co-resistance. Carbapenems are active against ESBL-ENT and tebipenem (TBP) is a new oral carbapenem in clinical development. The aim of the study was to assess resistance (R) among BSI isolates and activity of TBP and comparators against ENT collected in a 2019 surveillance study. Methods 2612 EN

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Popivanov, Georgi, Rumyana Markovska, Ivanka Gergova, et al. "An Intra-Hospital Spread of Colistin-Resistant K. pneumoniae Isolates—Epidemiological, Clinical, and Genetic Analysis." Medicina 60, no. 3 (2024): 511. http://dx.doi.org/10.3390/medicina60030511.

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Background and Objective: Klebsiella pneumoniae appears to be a significant problem due to its ability to accumulate antibiotic-resistance genes. After 2013, alarming colistin resistance rates among carbapenem-resistant K. pneumoniae have been reported in the Balkans. The study aims to perform an epidemiological, clinical, and genetic analysis of a local outbreak of COLr CR-Kp. Material and Methods: All carbapenem-resistant and colistin-resistant K. pneumoniae isolates observed among patients in the ICU unit of Military Medical Academy, Sofia, from 1 January to 31 October 2023, were included.

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Lin, Lynn-Yao, Ian Critchley та David Melnick. "Ceftazidime-avibactam and Meropenem Double Disk Diffusion Test for Identifying Carbapanem-Resistant Enterobacteriaceae and Distinguishing Between Serine and Metallo-β-Lactamase Producing Organisms". Open Forum Infectious Diseases 4, suppl_1 (2017): S375. http://dx.doi.org/10.1093/ofid/ofx163.923.

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Abstract Background Early detection of carbapenem-resistant Enterobacteriaceae(CRE) is crucial for selection of effective treatment. While KPC is the most prevalent carbapenemase in the US, phenotypic screening methods, such as the carbapenemase inactivation method (CIM) and CarbaNP, cannot easily distinguish between serine and metallo-β-lactamases (MBL). The aim of this study was to evaluate a simple double disk diffusion (DD) test to confirm carbapenem (meropenem) resistance (MER disk) and that resistance was due to a serine carbapenemase as indicated by susceptibility to ceftazidime-avibact

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Weber-Dąbrowska, Beata, Maciej Żaczek, Małgorzata Łobocka, et al. "Characteristics of Environmental Klebsiella pneumoniae and Klebsiella oxytoca Bacteriophages and Their Therapeutic Applications." Pharmaceutics 15, no. 2 (2023): 434. http://dx.doi.org/10.3390/pharmaceutics15020434.

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In recent years, multidrug-resistant (MDR) strains of Klebsiella pneumoniae have spread globally, being responsible for the occurrence and severity of nosocomial infections. The NDM-1-kp, VIM-1 carbapenemase-producing isolates as well as extended-spectrum beta lactamase-producing (ESBL) isolates along with Klebsiella oxytoca strains have become emerging pathogens. Due to the growing problem of antibiotic resistance, bacteriophage therapy may be a potential alternative to combat such multidrug-resistant Klebsiella strains. Here, we present the results of a long-term study on the isolation and b

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Ahmed El-Domany, Ramadan, Tarek El-Banna, Fatma Sonbol, and Samar Hamed Abu-Sayedahmed. "Co-existence of NDM-1 and OXA-48 genes in Carbapenem Resistant Klebsiella pneumoniae clinical isolates in Kafrelsheikh, Egypt." African Health Sciences 21, no. 2 (2021): 489–96. http://dx.doi.org/10.4314/ahs.v21i2.2.

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Background: The noteworthy spread of carbapenem-resistant K. pneumoniae (CR-KP) isolates represents a significant safety threat. Objective: Determination of the carbapenemase genes incidence among CR-KP clinical isolates in Kafrelsheikh, Egypt. Methods: A total of 230 K. pneumoniae isolates were recovered from four hospitals in Kafrelsheikh, Egypt. Susceptibility testing was conducted using Kirby-Bauer method and automated-Vitek2 system. CR-KP isolates were tested using modified Hodge test (MHT) and combined disk synergy test. PCR and DNA sequencing were conducted for CR-KP isolate

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Manju, Amandeep Kaur, Ashwini Manhas та ін. "A Comprehensive Study of Phenotypic and Genotypic Techniques to Detect Metallo-β-lactamases in Carbapenem-resistant Escherichia coli (E. coli) and Klebsiella pneumoniae (KP) Strains Derived through Numerous Clinical Specimens in Advanced Health care Facilities". Journal of Pure and Applied Microbiology 17, № 3 (2023): 1887–92. http://dx.doi.org/10.22207/jpam.17.3.54.

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In recent years, an increase in Escherichia coli and Klebsiella pneumoniae resistant to carbapenem was reported globally. Due to their high prevalence and extensive range of medical conditions, Escherichia coli and Klebsiella pneumoniae are both confirmed to be major public health concerns. Furthermore, carbapenem resistance restricts treatment options for individuals infected with these bacteria. Consequently, early detection of carbapenem resistance is essential for starting effective therapy, achieving successful management, and avoiding the infection from spreading further in the future. T

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Ran, Xia, Xue Chen, Cai Wang, Haiping Wang, Wei Xie, and Chunmei Jing. "Carbapenem-resistant Klebsiella pneumoniae infections in Chinese children: in vitro activities of ceftazidime-avibactam and aztreonam-avibactam against carbapenemase-producing strains in a two-center study." Frontiers in Cellular and Infection Microbiology 15 (March 26, 2025). https://doi.org/10.3389/fcimb.2025.1545999.

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ObjectiveThis study assessed epidemiology characteristics, carbapenem-resistance genes, and drug resistance to ceftazidime-avibactam (CZA) and aztreonam-avibactam (AZA) in children with carbapenem-resistant Klebsiella Pneumoniae (CRKP) infections.MethodsA total of 363 non-repetitive CRKP strains were collected from children who underwent two tertiary children’s hospital between 1 January 2021 and 30 June 2024 in Chongqing and Kunming in Southwest China. Carbapenem resistance genes and antimicrobial susceptibility were analyzed. Basic clinical characteristics of the patients were obtained from

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Yang, Ann Fan, Adrienne Sherman, Elizabeth Nazarian та ін. "Evidence of transmission of New Delhi metallo-β-lactamase-producing Klebsiella pneumoniae through a gastrointestinal endoscope without an elevator channel". Infection Control & Hospital Epidemiology, 2 квітня 2024, 1–6. http://dx.doi.org/10.1017/ice.2024.55.

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Abstract Objective: To investigate the source and transmission dynamics of an endoscope-associated New Delhi metallo-β-lactamase-producing Klebsiella pneumonia (NDM-KP) outbreak. Design: Epidemiological and genomic investigation. Setting: Academic acute care hospital in New Jersey. Patients: Five patients with active NDM-KP infection identified on clinical isolates, and four NDM-KP colonized patients identified via rectal swab screening. Results: Over a twelve-month period, nine patients were identified with NDM-KP infection or colonization. Whole-genome sequencing (WGS) revealed that all of t

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Coppi, Marco, Alberto Antonelli, Claudia Niccolai, et al. "Nosocomial outbreak by NDM-1-producing Klebsiella pneumoniae highly resistant to cefiderocol, Florence, Italy, August 2021 to June 2022." Eurosurveillance 27, no. 43 (2022). http://dx.doi.org/10.2807/1560-7917.es.2022.27.43.2200795.

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A nosocomial outbreak by cefiderocol (FDC)-resistant NDM-1-producing Klebsiella pneumoniae (NDM-Kp) occurred in a large tertiary care hospital from August 2021–June 2022 in Florence, Italy, an area where NDM-Kp strains have become endemic. Retrospective analysis of NDM-Kp from cases observed in January 2021–June 2022 revealed that 21/52 were FDC-resistant. The outbreak was mostly sustained by clonal expansion of a mutant with inactivated cirA siderophore receptor gene, which exhibited high-level resistance to FDC (MIC ≥ 32 mg/L) and spread independently of FDC exposure.

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Fu, Bo, Dandan Yin, Chengtao Sun, et al. "Clonal and Horizontal Transmission of bla _NDM among Klebsiella pneumoniae in Children’s Intensive Care Units." Microbiology Spectrum, June 27, 2022. http://dx.doi.org/10.1128/spectrum.01574-21.

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The bla NDM gene is playing an increasingly important role in infections caused by CR-KP, especially in children. However, systematic detection and bioinformatics analysis of NDM-KP in children's hospitals are lacking in China.

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Bakthavatchalam, Yamuna Devi, Abirami Shankar, Dhiviya Prabaa Muthuirulandi Sethuvel, Kalaiarasi Asokan, Kalaiarasi Kanthan, and Balaji Veeraraghavan. "Synergistic activity of fosfomycin–meropenem and fosfomycin–colistin against carbapenem resistant Klebsiella pneumoniae: an in vitro evidence." Future Science OA, February 26, 2020, FSO461. http://dx.doi.org/10.2144/fsoa-2019-0074.

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Aim: To evaluate the antibacterial activity of fosfomycin–meropenem and fosfomycin–colistin combinations against carbapenem-resistant Klebsiella pneumoniae (CR-Kp). Methods: A total of 50 CR-Kp isolates recovered from blood cultures were included in this study. All the CR-Kp isolates were screened for the presence of carbapenem resistant genes blaIMP. blaVIM. blaNDM. blaOXA-48 like, blaKPC. blaGES.#x00A0;and blaSPM. Combination testing of fosfomycin–meropenem and fosfomycin–colistin were performed using time-kill assay. Results: Fosfomycin–meropenem combination showed synergy in 20% of the tes

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Moulin, Estelle, Paraskevas Filippidis, Corinne Aymon Paire-Ficout, Dominique S. Blanc, Bruno Grandbastien, and Laurence Senn. "Successful control of an environmental reservoir of NDM-producing Klebsiella pneumoniae associated with nosocomial transmissions in a low-incidence setting." Antimicrobial Resistance & Infection Control 13, no. 1 (2024). http://dx.doi.org/10.1186/s13756-024-01488-0.

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Abstract Background The hospital wastewater system has been reported as a source of nosocomial acquisition of carbapenemase producing Enterobacteriaceae (CPE) in various settings. Cleaning and disinfection protocols or replacement of contaminated equipment often fail to eradicate these environmental reservoirs, which can lead to long-term transmission of CPE. We report a successful multimodal approach to control a New Delhi metallo-beta-lactamase positive Klebsiella pneumoniae (NDM-KP) nosocomial outbreak implicating contamination of sink traps in a low-incidence setting. Methods Following the

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Posteraro, Brunella, Flavio De Maio, Yair Motro, et al. "In-depth characterization of multidrug-resistant NDM-1 and KPC-3 co-producing Klebsiella pneumoniae bloodstream isolates from Italian hospital patients." Microbiology Spectrum, February 27, 2024. http://dx.doi.org/10.1128/spectrum.03305-23.

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ABSTRACT Bloodstream infection (BSI) caused by carbapenem-resistant Klebsiella pneumoniae (KP) poses significant challenges, particularly when the infecting isolate carries multiple antimicrobial resistance (AMR) genes/determinants. This study, employing short- and long-read whole-genome sequencing, characterizes six New Delhi metallo-β-lactamase (NDM) 1 and KP carbapenemase (KPC) 3 co-producing KP isolates, the largest cohort investigated in Europe to date. Five [sequence type (ST) 512] and one (ST11) isolates were recovered from patients who developed BSI from February to August 2022 or Febr

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Guzek, Aneta, Zbigniew Rybicki, Dariusz Tomaszewski, Katarzyna Mackiewicz, Wiesław Piechota, and Andrzej Chciałowski. "Outcomes of 23 patients diagnosed with New Delhi metallo-beta-lactamase (NDM)-producing Klebsiella pneumoniae infection treated with ceftazidime/avibactam and aztreonam at a single center in Poland." European Journal of Clinical Microbiology & Infectious Diseases, May 29, 2024. http://dx.doi.org/10.1007/s10096-024-04859-y.

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Abstract Purpose Amongst all etiologic hospital-acquired infection factors, K. pneumoniae strains producing New Delhi metallo-β-lactamase (KP-NDM) belong to pathogens with the most effective antibiotic resistance mechanisms. Clinical guidelines recommend using ceftazidime/avibactam with aztreonam (CZA + AT) as the preferred option for NDM-producing Enterobacterales. However, the number of observations on such treatment regimen is limited. This retrospective study reports the clinical and microbiological outcomes of 23 patients with KP-NDM hospital-acquired infection treated with CZA + AT at a

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Mileto, Irene, Greta Petazzoni, Marta Corbella, et al. "Rapid spread of a novel NDM-producing clone of Klebsiella pneumoniae CC147, Northern Italy, February to August 2023." Eurosurveillance 28, no. 42 (2023). http://dx.doi.org/10.2807/1560-7917.es.2023.28.42.2300522.

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New Delhi metallo-beta-lactamase (NDM)-producing Klebsiella pneumoniae (Kp) ST147 caused a large multi-hospital outbreak in Italy from 2018 to 2021. We describe a new ST6668 NDM-producing Kp clone, belonging to CC147, which rapidly spread across hospitals in the Pavia province (Northern Italy) from February to August 2023. Genomic analyses revealed that ST6668 is different from ST147 and fast evolving. As shown here, genomic surveillance programmes are useful for tracking the spread of new clones with reduced susceptibility to most antibiotics.

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Rodríguez-Noriega, Eduardo, Elvira Garza-González, Paola Bocanegra-Ibarias, et al. "A case–control study of infections caused by Klebsiella pneumoniae producing New Delhi metallo-beta-lactamase-1: Predictors and outcomes." Frontiers in Cellular and Infection Microbiology 12 (July 28, 2022). http://dx.doi.org/10.3389/fcimb.2022.867347.

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IntroductionInfections caused by antimicrobial-resistant bacteria are a significant cause of death worldwide, and carbapenemase-producing bacteria are the principal agents. New Delhi metallo-beta-lactamase-1 producing Klebsiella pneumoniae (KP-NDM-1) is an extensively drug-resistant bacterium that has been previously reported in Mexico. Our aim was to conduct a case–control study to describe the risk factors associated with nosocomial infections caused by K. pneumoniae producing NDM-1 in a tertiary-care hospital in Mexico.MethodsA retrospective case–control study with patients hospitalized fro

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Sattler, Janko, Christoph M. Ernst, Janine Zweigner, and Axel Hamprecht. "High frequency of acquired virulence factors in carbapenemase-producing Klebsiella pneumoniae isolates from a large German university hospital, 2013–2021." Antimicrobial Agents and Chemotherapy, October 4, 2024. http://dx.doi.org/10.1128/aac.00602-24.

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ABSTRACT Carbapenemase-producing Klebsiella pneumoniae (CP-Kp) isolates are a public health concern as they can cause severe hospital-acquired infections that are difficult to treat. It has recently been shown that CP-Kp can take up virulence factors from hypervirulent K. pneumoniae lineages. In this study, 109 clinical CP-Kp isolates from the University Hospital Cologne were examined for the presence of acquired virulence factors using whole-genome sequencing and phenotypic tests, and results were linked to clinical data. The virulence factor iuc was present in 18/109 of the CP-Kp isolates. O

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Yang, Chengcheng, Liang Wang, Jingnan Lv, et al. "Effects of different carbapenemase and siderophore production on cefiderocol susceptibility in Klebsiella pneumoniae." Antimicrobial Agents and Chemotherapy, October 29, 2024. http://dx.doi.org/10.1128/aac.01019-24.

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ABSTRACT The resistance mechanism of Gram-negative bacteria to the siderophore antibiotic cefiderocol is primarily attributed to carbapenemase and siderophore uptake pathways; however, specific factors and their relationships remain to be fully elucidated. Here, we constructed cefiderocol-resistant Klebsiella pneumoniae (CRKP) strains carrying different carbapenemases and knocked out siderophore genes to investigate the roles of various carbapenemases and siderophores in the development of cefiderocol resistance. Antimicrobial susceptibility testing revealed that both bla NDM and bla KPC signi

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Veloso, Marcelo, Patricio Arros, Joaquin Acosta, et al. "Antimicrobial resistance, pathogenic potential, and genomic features of carbapenem-resistant Klebsiella pneumoniae isolated in Chile: high-risk ST25 clones and novel mobile elements." Microbiology Spectrum, September 14, 2023. http://dx.doi.org/10.1128/spectrum.00399-23.

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ABSTRACT Multidrug- and carbapenem-resistant Klebsiella pneumoniae (CR- Kp ) are critical threats to global health and key traffickers of resistance genes to other pathogens. Despite the sustained increase in CR- Kp infections in Chile, few strains have been described at the genomic level, lacking details of their resistance and virulence determinants and the mobile elements mediating their dissemination. In this work, we studied the antimicrobial susceptibility and performed a comparative genomic analysis of 10 CR- Kp isolates from the Chilean surveillance of carbapenem-resistant Enterobacter

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Xu, Qi, Ruanyang Sun, Xiaoxuan Liu, et al. "Global dissemination of conjugative virulence plasmids co-harboring hypervirulence and multidrug resistance genes in Klebsiella pneumoniae." mSystems, March 25, 2025. https://doi.org/10.1128/msystems.01675-24.

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ABSTRACT Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hv Kp ) has led to a high mortality rate in the clinical setting and garnered significant attention in the clinical and scientific communities. It is still not clear which major mechanisms mediate the rapid evolution of hv Kp in clinical settings since the plasmid-encoding hypervirulence phenotype is considered non-conjugative. In this study, we revealed a conjugative plasmid, p16HN200-Vir, encoding virulence-associated iuc operon ( iucABCDiutA ) and resulting in a hypervirulent phenotype. In silico analysis of Kp strains fr

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Zhang, Xiaotuan, Weiliang Zeng, Jingchun Kong, et al. "The prevalence and mechanisms of heteroresistance to ceftazidime/avibactam in KPC-producing Klebsiella pneumoniae." Journal of Antimicrobial Chemotherapy, June 6, 2024. http://dx.doi.org/10.1093/jac/dkae174.

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Abstract Objectives To investigate the prevalence and mechanisms of ceftazidime/avibactam heteroresistance in KPC-producing Klebsiella pneumoniae (KPC-KP) isolates, as well as the role of heteroresistance in the transition of ceftazidime/avibactam susceptibility to resistance. Methods Clinical KPC-KP isolates were obtained from a tertiary hospital in China from 2016 to 2017 and 2019 to 2020. Antimicrobial susceptibility was determined by the broth microdilution method. Population analysis profiles were used to assess ceftazidime/avibactam heteroresistance. WGS and molecular cloning were conduc

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Alvarez, Carla, Marcela Nastro, Beatriz Goyheneche, et al. "NDM-5-producing Klebsiella pneumoniae ST258 in a university hospital in Argentina." Journal of Antimicrobial Chemotherapy, September 23, 2024. http://dx.doi.org/10.1093/jac/dkae337.

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Abstract Background A drastic increase in carbapenem resistance among Klebsiella pneumoniae isolates occurred during the period 2019–22. Three epidemiological changes could be evidenced: (i) NDM became the predominant carbapenemase; (ii) NDM-5 replaced NDM-1; and (iii) the emergence of NDM-producing K. pneumoniae ST258 (NDM-KpST258). Materials and methods Carbapenem-resistant K. pneumoniae isolates from patients on the ICU of a university hospital of Buenos Aires were studied during the period 2019–22. Identification was performed by MS and susceptibility by the Phoenix system (broth microdilu

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Tocco Tussardi, I., G. Stevanin, L. Montesarchio, et al. "Management and control of an outbreak of NDM-producing Klebsiella pneumoniae in a teaching hospital." European Journal of Public Health 33, Supplement_2 (2023). http://dx.doi.org/10.1093/eurpub/ckad160.1045.

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Abstract Background Outbreaks caused by New Delhi metallo-β-lactamase (NDM)-producing Enterobacteriaceae are a major public health threat. We report an outbreak caused by NDM-producing Klebsiella pneumoniae (KP) in an Italian teaching hospital and describe the composite management approach that led to a successful containment. Methods On August 12 2022, a 39-year old Ukrainian patient with known colonization (rectal swab) by NDM-producing KP was admitted to the Hematology Unit of the University Hospital of Verona, Italy. Six days after, a second patient tested positive for carbapenem-resistant

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Yang, Yunxing, Haiyang Liu, Lingxia Chen, et al. "Molecular characterization and comparison of bla _NDM-1 -carrying and bla _NDM-5 -harboring IncX3-type plasmids in carbapenem-resistant Klebsiella pneumoniae." Microbiology Spectrum, August 25, 2023. http://dx.doi.org/10.1128/spectrum.01028-23.

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ABSTRACT Carbapenem-resistant Klebsiella pneumoniae (CRKP), which harbors the bla NDM plasmid, has been reported extensively and is considered a global threat clinically. However, characterization and comparisons of bla NDM-1 -carrying and bla NDM-5 -harboring IncX3-type plasmids in CRKP are lacking. Here, we systematically compared the differences in the characteristics, genetic backgrounds, transferability, and fitness costs between bla NDM-1 -carrying and bla NDM-5 -carrying plasmids in K. pneumoniae isolates. Fifteen NDM-producing CRKP isolates were recovered from 1376 CRKP isolates betwee

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Bolano-Ardila, Nalleth Danieyis, Elsa De La Cadena, José Y. Rodríguez, Adriana Marin, Maria Virginia Villegas, and Maria F. Mojica. "P-1357. Molecular Mechanisms of Carbapenemase Genes Dissemination in Klebsiella pneumoniae in Two Colombian Cities (2018-2021)." Open Forum Infectious Diseases 12, Supplement_1 (2025). https://doi.org/10.1093/ofid/ofae631.1534.

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Abstract Background Colombia has been endemic for KPC for decades, mainly due to the clonal dissemination of blaKPC-3 among carbapenemase-producing K. pneumoniae (CP-Kp) sequence type (ST) 258 and plasmid dissemination of blaKPC-2 among different species of Gram-negatives. However, a recent surge in the detection of blaNDM among CP-Kp has raised concerns. Herein, we aimed to understand the dynamics of transmission of carbapenemase genes among CP-Kp clinical isolates in two cities of Colombia.Fig. 1.Molecular characterization of 31 CP-Kp collected between 2018 - 2019.MLST: Multi-locus sequence

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Xie, Xiaofang, Yaxuan Zhai, Zhichen Zhu, et al. "Genomic characteristics of ST6115 carbapenem-resistant Klebsiella pneumoniae coharboring blaNDM-1 and blaIMP-4." Frontiers in Microbiology 16 (February 5, 2025). https://doi.org/10.3389/fmicb.2025.1545161.

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ObjectivesThe aim of this study is to characterize the genomic features of ST6115 carbapenem-resistant Klebsiella pneumoniae (CRKP) co-harboring blaNDM-1 and blaIMP-4.MethodsThe genome sequences of one ST6115 Klebsiella pneumoniae (KP) strain and 12 ST17 KP strain were obtained through whole genome sequencing (WGS). Subsequently, a phylogenetic analysis was employed to ascertain the clonal relationship of these strains. The antimicrobial susceptibility testing (AST) was evaluated through the application of the minimum inhibitory concentration (MIC) methodology by the broth microdilution method

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Zomorodi, Abolfazl Rafati, Himen Salimizand, Niloufar Mohseni, et al. "Genomic Characterization of NDM‐1 Harboring Extensively‐Drug Resistance Klebsiella pneumoniae Isolate From ICU‐Admitted Patient With COVID‐19." Journal of Tropical Medicine 2025, no. 1 (2025). https://doi.org/10.1155/jotm/6616950.

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Currently, carbapenem‐resistant Klebsiella pneumoniae (CR‐KP) strains, particularly those producing New Delhi metallo‐beta‐lactamase (NDM), are increasingly recognized as a significant threat to global health. The present study aimed to conduct a genomic analysis of an NDM‐1‐producing CR‐KP strain isolated from patients with coronavirus disease of 2019 (COVID‐19) admitted to the intensive care unit (ICU). The K. pneumoniae isolate was obtained from the bronchoalveolar lavage fluid of a 68 year‐old male patient hospitalized in the ICU with COVID‐19 at Besat Hospital in Sanandaj, Iran. The minim

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Che, Haoyue, Bo Hu, Xiaoming Cui, et al. "Carbapenem treatment options for metallo-beta-lactamase: drug screening and dose optimization of meropenem-based combinations against NDM- or IMP-producing Klebsiella pneumoniae." Frontiers in Microbiology 16 (April 15, 2025). https://doi.org/10.3389/fmicb.2025.1490372.

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BackgroundThe global dissemination of carbapenemase-producing Klebsiella pneumoniae (CPKP) has been occurring at an alarming pace, especially for the metallo-β-lactamase (MBL) group. Current clinical data suggest that carbapenem is still irreplaceable in terms of safety and efficacy. For MBL-producing Klebsiella pneumoniae (MBL-KP), how to use carbapenem judiciously in the context of advocating carbapenem-sparing strategies remains largely undetermined.MethodsFour strains carrying different MBLs (two IMPs and two NDMs) were collected. The genome sequence, drug resistance phenotype, and synergi

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Kot, Barbara, Małgorzata Piechota, Piotr Szweda, et al. "Virulence analysis and antibiotic resistance of Klebsiella pneumoniae isolates from hospitalised patients in Poland." Scientific Reports 13, no. 1 (2023). http://dx.doi.org/10.1038/s41598-023-31086-w.

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AbstractKlebsiella pneumoniae (KP) is a nosocomial pathogen causing difficult-to-treat infections. The presence of virulence genes and antibiotic resistance of 109 KP isolates from hospitalized patients were investigated. Among them, 68.8% were multi-drug resistant (MDR) and 59.6% produced extended‐spectrum beta‐lactamases (ESBLs). Metallo-β-lactamases (MBLs) were produced by 22% of isolates (mainly from anus), including 16.5% of isolates producing New Delhi metallo-β-lactamase (NDM-1). The genes encoding adhesins (fimH—91.7%, mrkD—96.3%), enterobactin (entB—100%) and yersiniabactin (irp-1—88%

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Yin, Lijun, Lu Lu, Leiyan He, et al. "Molecular characteristics of carbapenem-resistant gram-negative bacilli in pediatric patients in China." BMC Microbiology 23, no. 1 (2023). http://dx.doi.org/10.1186/s12866-023-02875-0.

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Abstract Background Carbapenem-resistant gram-negative bacilli (CR-GNB) have been increasingly reported in China. However, dynamic monitoring data on molecular epidemiology of CR-GNB are limited in pediatric patients. Results 300 CR-GNB isolates (200 Carbapenem-resistant K. pneumoniae (CRKP), 50 carbapenem-resistant A.baumannii (CRAB) and 50 carbapenem-resistant P. aeruginosa (CRPA)) were investigated. The predominant carbapenemase gene was blaNDM−1 (73%) and blaKPC−2 (65%) in neonates and non-neonates. Meanwhile, the predominant STs were ST11 (54%) in neonates and ST17 (27.0%) and ST278 (20.0

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