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Relevant bibliographies by topics / NDR kinases

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Academic literature on the topic 'NDR kinases'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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Journal articles on the topic "NDR kinases"

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Kohler, Reto S., Debora Schmitz, Hauke Cornils, Brian A. Hemmings, and Alexander Hergovich. "Differential NDR/LATS Interactions with the Human MOB Family Reveal a Negative Role for Human MOB2 in the Regulation of Human NDR Kinases." Molecular and Cellular Biology 30, no. 18 (2010): 4507–20. http://dx.doi.org/10.1128/mcb.00150-10.

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ABSTRACT MOB proteins are integral components of signaling pathways controlling important cellular processes, such as mitotic exit, centrosome duplication, apoptosis, and cell proliferation in eukaryotes. The human MOB protein family consists of six distinct members (human MOB1A [hMOB1A], -1B, -2, -3A, -3B, and -3C), with hMOB1A/B the best studied due to their putative tumor-suppressive functions through the regulation of NDR/LATS kinases. The roles of the other MOB proteins are less well defined. Accordingly, we characterized all six human MOB proteins in the context of NDR/LATS binding and t

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Hergovich, Alexander, Samuel J. Bichsel, and Brian A. Hemmings. "Human NDR Kinases Are Rapidly Activated by MOB Proteins through Recruitment to the Plasma Membrane and Phosphorylation." Molecular and Cellular Biology 25, no. 18 (2005): 8259–72. http://dx.doi.org/10.1128/mcb.25.18.8259-8272.2005.

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ABSTRACT Human nuclear Dbf2-related kinases (NDRs) are up-regulated in certain cancer types, yet their precise function(s) and regulatory mechanism(s) still remain to be defined. Here, we show that active (phosphorylated on Thr444) and inactive human NDRs are both mainly cytoplasmic. Moreover, NDR kinases colocalize at the plasma membrane with human MOBs (hMOBs), which are recently described coactivators of human NDR in vitro. Strikingly, membrane targeting of NDR results in a constitutively active kinase due to phosphorylation on Ser281 and Thr444 that is further activated upon coexpression o

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Stegert, Mario R., Alexander Hergovich, Rastislav Tamaskovic, Samuel J. Bichsel, and Brian A. Hemmings. "Regulation of NDR Protein Kinase by Hydrophobic Motif Phosphorylation Mediated by the Mammalian Ste20-Like Kinase MST3." Molecular and Cellular Biology 25, no. 24 (2005): 11019–29. http://dx.doi.org/10.1128/mcb.25.24.11019-11029.2005.

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ABSTRACT NDR protein kinases are involved in the regulation of cell cycle progression and morphology. NDR1/NDR2 protein kinase is activated by phosphorylation on the activation loop phosphorylation site Ser281/Ser282 and the hydrophobic motif phosphorylation site Thr444/Thr442. Autophosphorylation of NDR is responsible for phosphorylation on Ser281/Ser282, whereas Thr444/Thr442 is targeted by an upstream kinase. Here we show that MST3, a mammalian Ste20-like protein kinase, is able to phosphorylate NDR protein kinase at Thr444/Thr442. In vitro, MST3 selectively phosphorylated Thr442 of NDR2, r

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Zallen, Jennifer A., Erin L. Peckol, David M. Tobin, and Cornelia I. Bargmann. "Neuronal Cell Shape and Neurite Initiation Are Regulated by the Ndr Kinase SAX-1, a Member of the Orb6/COT-1/Warts Serine/Threonine Kinase Family." Molecular Biology of the Cell 11, no. 9 (2000): 3177–90. http://dx.doi.org/10.1091/mbc.11.9.3177.

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The Caenorhabditis elegans sax-1 gene regulates several aspects of neuronal cell shape. sax-1 mutants have expanded cell bodies and ectopic neurites in many classes of neurons, suggesting that SAX-1 functions to restrict cell and neurite growth. The ectopic neurites in sensory neurons of sax-1mutants resemble the defects caused by decreased sensory activity. However, the activity-dependent pathway, mediated in part by the UNC-43 calcium/calmodulin-dependent kinase II, functions in parallel with SAX-1 to suppress neurite initiation. sax-1 encodes a serine/threonine kinase in the Ndr family that

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Gutiérrez-Escribano, Pilar, Alberto González-Novo, M. Belén Suárez, et al. "CDK-dependent phosphorylation of Mob2 is essential for hyphal development in Candida albicans." Molecular Biology of the Cell 22, no. 14 (2011): 2458–69. http://dx.doi.org/10.1091/mbc.e11-03-0205.

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Nuclear Dbf2-related (NDR) protein kinases are essential components of regulatory pathways involved in cell morphogenesis, cell cycle control, and viability in eukaryotic cells. For their activity and function, these kinases require interaction with Mob proteins. However, little is known about how the Mob proteins are regulated. In Candida albicans, the cyclin-dependent kinase (CDK) Cdc28 and the NDR kinase Cbk1 are required for hyphal growth. Here we demonstrate that Mob2, the Cbk1 activator, undergoes a Cdc28-dependent differential phosphorylation on hyphal induction. Mutations in the four C

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He, Ying, Kazuo Emoto, Xiaolan Fang, et al. "Drosophila Mob Family Proteins Interact with the Related Tricornered (Trc) and Warts (Wts) Kinases." Molecular Biology of the Cell 16, no. 9 (2005): 4139–52. http://dx.doi.org/10.1091/mbc.e05-01-0018.

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The function of Tricornered (Trc), the Drosophila Ndr (Nuclear Dbf2-related) serine/threonine protein kinase, is required for the normal morphogenesis of a variety of polarized outgrowths including epidermal hairs, bristles, arista laterals, and dendrites. In yeast the Trc homolog Cbk1 needs to bind Mob2 to activate the RAM pathway. In this report, we provide genetic and biochemical data that Drosophila Trc also interacts with and is activated by Drosophila Dmob proteins. In addition, Drosophila Mob proteins appear to interact with the related Warts/Lats kinase, which functions as a tumor supp

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He, Ying, Xiaolan Fang, Kazuo Emoto, Yuh-Nung Jan, and Paul N. Adler. "The Tricornered Ser/Thr Protein Kinase Is Regulated by Phosphorylation and Interacts with Furry during Drosophila Wing Hair Development." Molecular Biology of the Cell 16, no. 2 (2005): 689–700. http://dx.doi.org/10.1091/mbc.e04-09-0828.

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The Trc/Ndr/Sax1/Cbk1 family of ser/thr kinases plays a key role in the morphogenesis of polarized cell structures in flies, worms, and yeast. Tricornered (Trc), the Drosophila nuclear Dbf2-related (Ndr) serine/threonine protein kinase, is required for the normal morphogenesis of epidermal hairs, bristles, laterals, and dendrites. We obtained in vivo evidence that Trc function was regulated by phosphorylation and that mutations in key regulatory sites resulted in dominant negative alleles. We found that wild-type, but not mutant Trc, is found in growing hairs, and we failed to detect Trc in pu

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Seiler, Stephan, Nico Vogt, Carmit Ziv, Rena Gorovits, and Oded Yarden. "The STE20/Germinal Center Kinase POD6 Interacts with the NDR Kinase COT1 and Is Involved in Polar Tip Extension inNeurospora crassa." Molecular Biology of the Cell 17, no. 9 (2006): 4080–92. http://dx.doi.org/10.1091/mbc.e06-01-0072.

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Members of the Ste20 and NDR protein kinase families are important for normal cell differentiation and morphogenesis in various organisms. We characterized POD6 (NCU02537.2), a novel member of the GCK family of Ste20 kinases that is essential for hyphal tip extension and coordinated branch formation in the filamentous fungus Neurospora crassa. pod-6 and the NDR kinase mutant cot-1 exhibit indistinguishable growth defects, characterized by cessation of cell elongation, hyperbranching, and altered cell-wall composition. We suggest that POD6 and COT1 act in the same genetic pathway, based on the

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Hergovich, Alexander. "The Roles of NDR Protein Kinases in Hippo Signalling." Genes 7, no. 5 (2016): 21. http://dx.doi.org/10.3390/genes7050021.

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Sharif, Ahmad A. D., and Alexander Hergovich. "The NDR/LATS protein kinases in immunology and cancer biology." Seminars in Cancer Biology 48 (February 2018): 104–14. http://dx.doi.org/10.1016/j.semcancer.2017.04.010.

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Dissertations / Theses on the topic "NDR kinases"

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Kastner, Peter Michael. "Cellular and molecular analysis of NDR and LATS kinases in dictyostelium." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-133383.

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Kastner, Peter Michael [Verfasser], and Michael [Akademischer Betreuer] Schleicher. "Cellular and molecular analysis of NDR and LATS kinases in dictyostelium / Peter Michael Kastner. Betreuer: Michael Schleicher." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2010. http://d-nb.info/1015131190/34.

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Stegert, Mario Reinhard. "Functional characterisation of the mammalian NDR1 and NDR2 protein kinases and their regulation by the mammalian Ste20-like kinase MST3 /." Basel : [s.n.], 2005. http://edoc.unibas.ch/diss/DissB_7330.

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MILON, LAURENCE. "La famille des nm23/ndp kinases humaines clonage de l'adnc, caracterisation biochimique et localisation mitochondriale de la nucleoside diphosphate kinase nm23-h4." Paris 6, 2000. http://www.theses.fr/2000PA066332.

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Les nucleoside diphosphate kinases sont les enzymes responsables in vivo de la synthese des nucleosides triphosphates a partir de l'atp. Elles sont impliquees dans des fonctions cellulaires normales et pathologiques, eventuellement independamment de leur activite enzymatique mais les mecanismes mis en jeu sont actuellement mal definis. Chez l'homme, six isoformes sont decrites a ce jour : nm23-h1, nm23-h2, dr-nm23, nm23-h4, nm23-h5 et nm23-h6. Mon travail a consiste en l'etude de nm23-h4, dont l'existence a ete mise en evidence au laboratoire. J'ai clone l'adnc nm23-h4. Le gene est localise su

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Bettoun, Audrey. "The NDR1 Kinase, a New Player in Oncogenic Signalling of Ral GTPases, Functions as a Linchpin Between Cancer Cell Survival and Death." Thesis, Paris 11, 2015. http://www.theses.fr/2015PA11T047.

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Des mutations du gène Ras jouent un rôle essentiel dans le développement tumoral. Les GTPases Ral , RalA et RalB, sont des effecteurs proximaux de l’oncogène Ras. RalA permet la croissance en absence de substrat et RalB est nécessaire à l'autophagie et à la résistance à l'apoptose des cellules cancéreuses. Cette thèse a pour objectif de clarifier les mécanismes moléculaires de la signalisation Ral impliqués dans l’oncogenèse dépendante des protéines Ras.Des criblages par double hydride ont été effectués par notre équipe et un interactome de Ral a été établi. Ce criblage a montré une interactio

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GIL-RAVEH, SHARONA. "Biochemical and structural analysis of human ndp kinase b associated to dna." Paris 6, 2001. http://www.theses.fr/2001PA066104.

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La nucleoside diphosphate kinase catalyse la phosphorylation reversible d'un nucleoside triphosphate a un nucleoside disphosphate. Elle est presente de maniere ubiquitaire dans tous les organismes, de la bacterie a l'humain. Recemment, la ndp kinase a ete impliquee dans les mecanismes de regulation comme la differenciation, la proliferation et la dissemination metastasique des tumeurs humaines. Une des isoformes humaines de cette enzyme, la ndp kinase b codee par le gene nm23-h2 a recemment ete impliquee dans la regulation de l'expression de l'oncogene c-myc. Elle est capable de se fixer a l'a

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Heilig, Yvonne [Verfasser], Stephan [Akademischer Betreuer] Seiler, and Andreas [Akademischer Betreuer] Wodarz. "Characterization of NDR kinase signalling pathways during septum formation in Neurospora crassa / Yvonne Heilig. Gutachter: Stephan Seiler ; Andreas Wodarz. Betreuer: Stephan Seiler." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2013. http://d-nb.info/1044871822/34.

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SELLAM, OLIVIER. "La nucleoside diphosphate kinase des proprietes regulatrices pour une enzyme du metabolisme ? contribution a l'etude de la ndp kinase de dictyostelium discoideum." Paris 7, 1998. http://www.theses.fr/1998PA077149.

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La nucleoside diphosphate kinase (ndp kinase) est une enzyme du metabolisme qui catalyse la synthese des ribo- et desoxyribo-nucleosides triphosphates a partir de leurs precurseurs diphosphates selon un mecanisme de type ping-pong. C'est un hexamere de sous-unites identiques de 17 kda dont la structure tridimensionnelle est connue. L'implication de ndp kinases dans le developpement et la metastase a ete mise en evidence respectivement chez l'homme et la drosophile. Par ailleurs, il a ete recemment montre que la ndp kinase humaine est capable de se fixer sur le promoteur de l'oncogene c-myc et

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Bourens, Myriam. "Rôle du complexe RAM et de la NDR kinase Cbk1p dans la séparation cellulaire, la polarité et la fertilité chez la levure Saccharomyces cerevisiae." Paris 11, 2008. http://www.theses.fr/2008PA112146.

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La polarité cellulaire est un phénomène central dans tous les organismes. Elle organise la cellule en permettant notamment une croissance localisée à un site précis de la membrane, nettement visible dans les neurones. Chez la levure Saccharomyces cerevisiae la polarité est également importante lors de diverses événements cellulaires, la sélection du site de bourgeonnement, la croissance végétative avec ses cellules ovales, la croissance filamenteuse avec ses cellules allongées et au cours du croisement avec la formation d’un long prolongement cytoplasmique, le shmoo permettant la formation d’u

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Ragan, Timothy James. "Regulation of S6K1 Protein Kinae Activation by its C-Terminal Autoinhibitory Domain." Scholarly Repository, 2008. http://scholarlyrepository.miami.edu/oa_dissertations/125.

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Signal transduction kinases lie at the heart of the cell's ability to respond to environmental cues. These kinases are typically controlled by post-translational modification, most commonly by phosphorylation. S6K1alphaII is a member of the AGC subfamily of serine-threonine protein kinases, whereby catalytic activation requires phosphorylation of critical residues in the conserved T-loop (T229) and hydrophobic motif (T389) regions of its catalytic kinase domain. In addition to its kinase domain, S6K1 contains a C-terminal autoinhibitory domain (AID, residues 399-502), which inhibits T-loop an

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Book chapters on the topic "NDR kinases"

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Hergovich, Alexander. "Measuring the Kinase Activities of the LATS/NDR Protein Kinases." In Methods in Molecular Biology. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8910-2_23.

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"NDP Kinases." In Encyclopedia of Cancer. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-16483-5_3990.

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Mari, F., and X. Xie. "Multidimensional NMR investigation of the Neurotoxic Peptide Mastoparan in the Absence and Presence of Calmodulin." In Biological NMR Spectroscopy. Oxford University Press, 1997. http://dx.doi.org/10.1093/oso/9780195094688.003.0019.

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Calmodulin (CaM) is the major Ca2+ receptor in eukaryotic cells (Means and Rasmussen, 1988). This paper begins an investigation into the structural requirements for neurotoxic peptide binding to CaM. In resting cells, CaM is deficient in Ca2+ (the protein has the potential for binding four Ca2+ ions with high affinity, pKd > 6 (Means and Rasmussen, 1988)). Following nerve cell excitation, intracellular levels of Ca2+ increase dramatically, from about 0.1 μM to about 10 μM, allowing CaM to become fully-loaded with Ca2+ . Ca2+ - loaded CaM has the ability to activate a number of neural enzymes, including cyclic nucleotide phosphodiesterase, adenylate cyclase, Ca2+ - CaM kinase and calcineurin (Kennedy, 1989). A tight-binding neurotoxic peptide would be expected to competitively inhibit activation of these enzymes. The high level of intercellular coordination required by higher organisms is attained, in part, by the complex interplay of the nervous and endocrine systems. Two important second messengers are involved in information transfer processes associated with the normal operation of these two systems: cyclic AMP (cAMP) and Ca2+ . Cyclic AMP is involved in trans-membrane information flow following the interaction of cell surface receptors with certain hormones (e.g., glucagon, epinephrine and ACTH), while Ca2+ is the principal information carrier in the nerve cell following stimulation of the system by membrane depolarization. CaM plays a pivotal role in second messenger function in both the nervous and endocrine systems. In the nervous system, calmodulin is the principal target for Ca2+. In the endocrine system, CaM (complexed with Ca2+) is responsible for activating the enzymes responsible for both cAMP synthesis (i.e., adenylate cyclase) and degradation (i.e., cyclic nucleotide phosphodiesterase). Additional linkage between the nervous and endocrine systems is evident from the fact that both systems are responsive to some of the same peptide messengers. For example, insulin, glucagon, angiotensin, and somatostatin have been found in the brain, and may function as neurotransmitters (Malencik and Anderson, 1982) perhaps through CaM mediation.

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Conference papers on the topic "NDR kinases"

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Chan, Kai-Hui, Larry Paris, Lin-Jen Ma, Renn-Shiuan Wei, Choon-Yee Tan, and Christina L. Chang. "Abstract 4074: Alterations of NDP kinase A/ NM23-H1 deregulatec-myctranscription." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-4074.

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Tsao, Ning, Yu-Jyun Deng, Zee-Fen Chang, and Wei Zhang. "Abstract 3014: Identification of the NDP kinase critical for DNA repair." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-3014.

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Smith, M., J. A. Ware, E. T. Fossel, and E. W. Salzman. "MEASUREMENT OF CYTOPLASMIC [MG++] IN PLATELETS BY NMR AND NULL-POINT TITRATION WITH ATOMIC ABSORPTION SPECTROSCOPY." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642818.

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Magnesium is a cofactor for phosphatases, kinases, and synthetases in all cells, and thus the cytoplasmic [Mg++] influences most intracellular processes. The concentration of cytoplasmic free Mg++ varies considerably among different cell types and has been measured in platelets, as most techniques for [Mg++] measurement are suitable only for cells large enough to microinject. Incorrect estimates of this value could markedly affect many Intracellular investigations, including calibration of platelet [Ca++] with aequorin and other Ca++ -sensitive probes. We measured cytoplasmic free [Mg++] by tw

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Ware, J. A., M. Smith, and E. W. Salzman. "DIACYLGLYCEROL AND PHORBOL ESTER REDUCE AEQUORIN-INDICATED [Ca++] ELEVATIONS INDUCED BY THROMBIN OR ADP." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644503.

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Platelet aggregation and secretion induced by phorbol ester (PMA) or diacylglycerol (DAG) are preceded by an increase in [Ca++] that is detected byaequorin, but not by quin2, fura-2, or indo-1, suggesting that these indicatorsreflect different aspects of Ca++ homeostasis, possibly different functional Ca++ pools. Addition of two conventional agonists in subthreold concentrations synergistically enhances the [Ca++] rise and aggregation.However, if PMA or DAG is the first agonist the subsequent quin2-indicated [Ca++] rise after thrombin is reduced.Whether aequorin-indicated [Ca++] is similarly a

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Siess, W., and E. G. Lapetina. "SYNERGISM OF Gi-DISSOCIATION AND PROTEIN KINASE C STIMULATION IN PLATELET ACTIVATION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644511.

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Epinephrine or UK 14304 (a specific (α2-adrenoceptor agonist) synergizes with phorbol esters (phorbol 12,13-dibutyrate, PdBu) or bioactive diacylglycerols (sn-1,2-dioctanoylglycerol, DiC8) to induce aggregation and ATP-secretion of platelets. The effect on aggregation is more pronounced than on secretion, and it is observed in aspirinized platelet-rich plasma or suspensions of washed platelets containing ADP-scavengers. No prior shape change is found. In the presence of epinephrine, DiCg induces reversible aggregation and PdBu evokes irreversible aggregation that correlates with the effects, o

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Kienast, J., J. Arnout, G. Pfliegler, H. Deckmyn, B. Hoet, and J. Vermylen. "DISSOCIATION OF PHOSPHOLIPASE A2 ACTIVATION FROM CYTOSOLIC FREE CA2+ MOBILIZATION IN PLATELETS EXPOSED TO FLUORIDE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644529.

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Elevated cytosolic free Ca2+ concentrations ([Ca2+]i) are thought to be required for phosphol ipase A2 activity to liberate arachidonic acid (AA) from membrane phospholipids in platelets. The major AA metabolite formed during agonist-induced platelet activation is thromboxane A2 (TxA2). We have investigated the effect of sodium fluoride (NaF) on platelet TxAz formation in correlation to platelet functional changes (aggregation and release of ATP) and intracellular events specific for either agonist- or antagonist-induced platelet responses. A first peak in platelet TxAffi formation reaching 30

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Johnson, G. J., P. C. Dunlop, M. J. Rabiet, L. A. Leis, and AH L. From. "THE DIHYDROPYRIDINE CALCIUM CHANNEL AGONIST, BAY K 8644, AND THE ANTAGONIST, NIFEDIPINE, INHIBIT U46619-INDUCED HUMAN PLATELET ACTIVATION BY COMPETITIVE BINDING TO THE THROMBOXANE A22/PGH2 RECEPTOR." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643756.

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The dihydropyridine (DP) Ca2+ channel antagonist, nifedipine (NF), inhibits platelet aggregation .in vitro and ex vivo by an undefined mechanism. Inhibition of Ca2+ influx via Ca2+ channels is a postulated mechanism, but voltage-dependent Ca2+ channels have not been demonstrated in platelets. We previously observed that NF blocked thromboxane A2 (TXA2)-induced platelet aggregation and secretion. In order to further evaluate the mechanism of DP inhibition of platelet activation, we studied the effects of NF and BAY K 8644, (BAY), a DP with opposite (agonist) effects on muscle cells, on human pl

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