Relevant bibliographies by topics / NDSR

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'NDSR'

Author: Grafiati
Published: 4 June 2021
Last updated: 15 February 2022

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Journal articles on the topic "NDSR"

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Lloyd-Baynes, Frances, Erin Barsan, Meg Black, and Heidi Raatz. "NDSR Art @ Mia." Art Documentation: Journal of the Art Libraries Society of North America 38, no. 2 (September 2019): 262–78. http://dx.doi.org/10.1086/706102.

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Lin, Annie, Nancy Morgan, Agnes Kwon, Christy Tangney, Linda Van Horn, and Bonnie Spring. "Comparison of Food Composition Databases from Two Popular Commercial Nutrition Apps with a Research Food and Nutrient Database." Current Developments in Nutrition 4, Supplement_2 (May 29, 2020): 1369. http://dx.doi.org/10.1093/cdn/nzaa060_007.

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Abstract Objectives Increasing interest in using commercial nutrition apps to evaluate energy intake and diet quality warrants further investigation of how diet data are being analyzed by clinicians. Few studies have compared food composition databases from commercial apps with a validated nutrient database used by the scientific community. We investigated the reliability of MyFitnessPal (v19.4.0) and 2017 CalorieKing databases with the 2017 Nutrition Coordinating Center Nutrition Data System for Research (NDSR) database. Methods The 50 most consumed foods were identified from an urban weight loss study. A single investigator searched each database to document data on calories and nutrients (i.e., total carbohydrates, sugars, fiber, protein, and total and saturated fat). Intraclass correlation coefficient (ICC) analyses evaluated the reliability between each commercial database with the NDSR; an ICC ≥ 0.90 was considered excellent; 0.75 to < 0.90 as good; 0.50 to < 0.75 as moderate; and < 0.50 as poor. Sensitivity analyses determined whether reliability differed by most frequently consumed food groups. Results The 3 most frequently consumed food groups were Fruits (15 items), Vegetables (13 items) and Protein (9 items). There was excellent reliability between CalorieKing and NDSR for all diet data (ICC range = 0.90–1.00). Between MyFitnessPal and NDSR, calories and nutrients had excellent reliability (ICC range = 0.90–1.00), except for total fat (ICC = 0.89) and fiber (ICC = 0.67). Sensitivity analyses showed good to excellent reliability between both commercial databases with NDSR for Vegetables and Protein groups (ICC range = 0.86–1.00). However, MyFitnessPal and NCC had poor reliability in calories, total carbohydrate, and fiber within the Fruit group (ICC range = 0.33–0.43). Conclusions CalorieKing had stronger agreement with NDSR. The wide range of ICCs between MyFitnessPal and NDSR is attributed to poor reliability among foods within the Fruit group. Our findings illustrate variability in nutrient data across commercial databases that can impact use in clinical nutrition analysis and translation of evidence-based interventions into practice. Future studies are needed to compare other popular commercial mobile nutrition apps with NDSR and/or other validated nutrient databases. Funding Sources The first author is supported by the National Cancer Institute.
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Chin, Elizabeth L., Gabriel Simmons, Yasmine Y. Bouzid, Annie Kan, Dustin J. Burnett, Ilias Tagkopoulos, and Danielle G. Lemay. "Nutrient Estimation from 24-Hour Food Recalls Using Machine Learning and Database Mapping: A Case Study with Lactose." Nutrients 11, no. 12 (December 13, 2019): 3045. http://dx.doi.org/10.3390/nu11123045.

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The Automated Self-Administered 24-Hour Dietary Assessment Tool (ASA24) is a free dietary recall system that outputs fewer nutrients than the Nutrition Data System for Research (NDSR). NDSR uses the Nutrition Coordinating Center (NCC) Food and Nutrient Database, both of which require a license. Manual lookup of ASA24 foods into NDSR is time-consuming but currently the only way to acquire NCC-exclusive nutrients. Using lactose as an example, we evaluated machine learning and database matching methods to estimate this NCC-exclusive nutrient from ASA24 reports. ASA24-reported foods were manually looked up into NDSR to obtain lactose estimates and split into training (n = 378) and test (n = 189) datasets. Nine machine learning models were developed to predict lactose from the nutrients common between ASA24 and the NCC database. Database matching algorithms were developed to match NCC foods to an ASA24 food using only nutrients (“Nutrient-Only”) or the nutrient and food descriptions (“Nutrient + Text”). For both methods, the lactose values were compared to the manual curation. Among machine learning models, the XGB-Regressor model performed best on held-out test data (R2 = 0.33). For the database matching method, Nutrient + Text matching yielded the best lactose estimates (R2 = 0.76), a vast improvement over the status quo of no estimate. These results suggest that computational methods can successfully estimate an NCC-exclusive nutrient for foods reported in ASA24.
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Miller, Paige E., Diane C. Mitchell, Priscilla L. Harala, Janet M. Pettit, Helen Smiciklas-Wright, and Terryl J. Hartman. "Development and evaluation of a method for calculating the Healthy Eating Index-2005 using the Nutrition Data System for Research." Public Health Nutrition 14, no. 2 (June 25, 2010): 306–13. http://dx.doi.org/10.1017/s1368980010001655.

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AbstractObjectiveTo develop and evaluate a method for calculating the Healthy Eating Index-2005 (HEI-2005) with the widely used Nutrition Data System for Research (NDSR) based on the method developed for use with the US Department of Agriculture’s (USDA) Food and Nutrient Dietary Data System (FNDDS) and MyPyramid Equivalents Database (MPED).DesignCross-sectional.SettingNon-institutionalized, community-dwelling adults aged 70 years and above.SubjectsTwo hundred and seventy-one adults participating in the Geisinger Rural Aging Study (GRAS) and 620 age- and race-matched adults from the National Health and Nutrition Examination Survey 2001–2002 (NHANES) were included in the analysis. The HEI-2005 scores were generated using NDSR in GRAS and compared to scores generated using FNDDS and MPED in NHANES.ResultsSimilar total HEI-2005 scores (mean 62·0 (se 0·75) in GRAS v. 57·4 (se 0·55) in NHANES) were estimated, and the individual components most strongly correlated with total score in both samples were compared. Cronbach’s coefficient α values of HEI-2005 were 0·52 in GRAS and 0·43 in NHANES.ConclusionsSince NDSR is commonly used for educational purposes, in clinical settings and in nutrition research, it is important to develop methodology for assessing diet quality through the use of HEI-2005 with this dietary analysis software application and its accompanying food and nutrient database. Results from the present study show that HEI-2005 scores can be generated with NDSR using the method described in the present study and the detailed USDA Center for Nutrition Policy and Promotion technical report as guidance.
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Griffiths, Carly, Lisa Harnack, and Mark A. Pereira. "Assessment of the accuracy of nutrient calculations of five popular nutrition tracking applications." Public Health Nutrition 21, no. 8 (March 14, 2018): 1495–502. http://dx.doi.org/10.1017/s1368980018000393.

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AbstractObjectiveTo assess the accuracy of nutrient intake calculations from leading nutrition tracking applications (apps).DesignNutrient intake estimates from thirty 24 h dietary recalls collected using Nutrition Data System for Research (NDSR) were compared with intake calculations from these recalls entered by the researcher into five free nutrition tracking apps. Apps were selected from the Apple App Store based on consumer popularity from the list of free ‘Health and Fitness’ apps classified as a nutrition tracking apps.SubjectsDietary recall data collected from thirty lower-income adults.ResultsCorrelations between nutrient intake calculations from NDSR and the nutrition tracking apps ranged from 0·73 to 0·96 for energy and macronutrients. Correlations for the other nutrients examined (Na, total sugars, fibre, cholesterol, saturated fat) ranged from 0·57 to 0·93. For each app, one or more mean nutrient intake calculations were significantly lower than those from NDSR. These differences included total protein (P=0·03), total fat (P=0·005), Na (P=0·02) and cholesterol (P=0·005) for MyFitnessPal; dietary fibre (P=0·04) for Fitbit; total protein (P=0·0004), total fat (P=0·008), Na (P=0·002), sugars (P=0·007), cholesterol (P=0·0006) and saturated fat (P=0·005) for Lose It!; Na (P=0·03) and dietary fibre (P=0·005) for MyPlate; and total fat (P=0·03) for Lifesum.ConclusionsFindings suggest that nutrient calculations from leading nutrition tracking apps tend to be lower than those from NDSR, a dietary analysis software developed for research purposes. Further research is needed to evaluate the validity of the apps when foods consumed are entered by consumers.
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Ghosh, Dipak K., and Richard St J. Lambert. "NdSr isotopic study of Proterozoic to Triassic sediments from southeastern British Columbia." Earth and Planetary Science Letters 94, no. 1-2 (August 1989): 29–44. http://dx.doi.org/10.1016/0012-821x(89)90081-2.

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Vecchione, A., M. Gombos, S. Pace, L. Marchese, G. Cerrato, C. Tedesco, P. W. Stephens, and C. Noce. "Crystal structure and morphology of the NdSr 2 RuCu 2 O y compound." European Physical Journal B 26, no. 1 (March 2002): 51–55. http://dx.doi.org/10.1140/epjb/e20020065.

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VECCHIONE, A., M. GOMBOS, C. TEDESCO, A. IMMIRZI, L. MARCHESE, A. FRACHE, C. NOCE, and S. PACE. "SYNTHESIS, MORPHOLOGY AND STRUCTURAL PROPERTIES OF (GD,ND)SR2RUCU2O8 SAMPLES." International Journal of Modern Physics B 17, no. 04n06 (March 10, 2003): 899–904. http://dx.doi.org/10.1142/s0217979203016790.

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NdSr 2 RuCu 2 O x material has been prepared as polycrystalline powder by solid state reaction. The compound has been investigated by synchrotron x-ray powder diffraction and scanning electron microscopy. The experimental results show that the average crystal structure is a disordered cubic perovskite with Nd and Sr cations occupying the same site and the same substitution is found for Cu and Ru atoms. A comparison between the crystal structure and morphology of this compound and the superconducting tetragonal GdSr 2 RuCu 2 O 8 is also discussed.
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Uporov, S. A., V. Ya Mitrofanov, O. M. Fedorova, and A. M. Yankin. "Influence of thermal processing on magnetotransport characteristics of NdSr 2 Mn 2 O 7+ δ." Materials Research Bulletin 67 (July 2015): 201–6. http://dx.doi.org/10.1016/j.materresbull.2015.03.007.

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Lee, H. K., and K. D. Kim. "Occurrence of Superconductivity in Ba-Doped NdSr2(Cu,Mo)3Oz." International Journal of Modern Physics B 17, no. 18n20 (August 10, 2003): 3622–28. http://dx.doi.org/10.1142/s0217979203021514.

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Polycrystalline samples of Nd ( Sr 2-y Ba y)( Cu 3-x Mo x) O z (0 ≤ y ≤ 0.5, 0.1 ≤ x ≤ 0.3) with tetragonal structure were synthesized and investigated by powder X-ray diffraction, electrical resistivity, magnetic susceptibility and thermoelectric power measurements. Contrary to the absence of superconductivity of the Ba-free samples, superconductivity can be achieved by partially substituting Ba for Sr in semiconducting NdSr 2( Cu 3-x Mo x) O z (0.15 ≤ x ≤ 0.3). Thermoelectric power measurements reveal that all the samples are in the underdoped state and the partial substitution of Ba for Sr results in an increase of the carrier density on the superconducting layers.
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Dissertations / Theses on the topic "NDSR"

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CARBONARO, DANIELLE P. "Designing a Database and Pilot Testing to Properly Track Food Group Consumption in Overweight/Obese Postpartum Women Enrolled in a Dietary Intervention Study." University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1218058036.

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Quiroz, Rojas Edward Alberto. "Vulnerabilidad sísmica de una edificación escolar típica módulo 780 Pre NDSR-1997 mediante modelos no lineales." Master's thesis, Pontificia Universidad Católica del Perú, 2017. http://tesis.pucp.edu.pe/repositorio/handle/123456789/8610.

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La presente tesis denominada “Vulnerabilidad sísmica de una edificación escolar típica módulo 780 Pre NDSR-1997 mediante modelos no lineales” comprende el estudio de dos módulos escolares de dos y tres pisos denominados 780 Pre NDSR-1997 en el departamento de Lima, específicamente en Lima Metropolitana, esta denominación se debe a que fueron construidos bajo los lineamientos normativos antes de la norma de diseño sismorresistente del año 1997. La vulnerabilidad sísmica de los módulos se obtuvo partir de las “funciones de vulnerabilidad” en el que se relacionó la distorsión máxima de la estructura y el daño esperado obtenido a partir de la curva de capacidad bilinealizada relacionando los desplazamientos máximos en el techo con cada nivel de daño dado. Para la determinación de la respuesta de la estructura en términos de distorsión máxima se empleó la metodología propuesta por Miranda con parámetros en el rango elástico y parámetros en el rango inelástico. En el capítulo I se muestra una descripción estadística de la problemática de los colegios existentes, y los lineamientos seguidos por el Gobierno a través del PRONIED a fin de mitigar los daños ocasionados por eventos sísmicos a estas construcciones. Se describen además los objetivos del estudio. En el capítulo II se describen los antecedentes de estudios que preceden a la presente investigación específicamente estudios de desempeño y vulnerabilidad sísmica a colegios pre y post Norma de diseño sismorresistente del año 2007. En el capítulo III se presenta el marco teórico y conceptual de los procedimientos tomados para realizar el presente estudio. Se ven temas como modelos no lineales de los materiales, respuesta no lineal de los elementos y de la estructura, procedimientos y métodos para evaluar el daño de estructura y los niveles de desempeño sísmico de las mismas. En los capítulos IV y V se describen los procedimientos para la evaluación de la vulnerabilidad y los resultados de los análisis realizados.
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Gallo, Solange Leda. "Texto : como apre(e)nder essa materia?" [s.n.], 1990. http://repositorio.unicamp.br/jspui/handle/REPOSIP/270673.

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Orientador: Eni P. Orlandi
Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Estudos da Linguagem
Made available in DSpace on 2018-07-19T00:49:06Z (GMT). No. of bitstreams: 1 Gallo_SolangeLeda_D.pdf: 3066400 bytes, checksum: cc5f51c9c3d2fed23149138427e645e3 (MD5) Previous issue date: 1994
Resumo: A tese "Texto: como apre(e)nder essa matéria?" apresenta uma proposta de trabalho com textos no 1o. grau (5a. a 8a. série). Trata-se de uma prática, a Textualização, proposta dentro de uma concepção discursiva da linguagem. Essa prática é apresentada na tese à vista da análise de uma experiência realizada em uma escola de 1o. grau da França e a noção de "Textualização" é construída a partir da noção de Escrita.
Abstract: Not informed.
Doutorado
Doutor em Linguística
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Zakaria, Ryadh Abdullah. "NDIR instrumentation design for Carbon Dioxide gas sensing." Thesis, Cranfield University, 2010. http://dspace.lib.cranfield.ac.uk/handle/1826/6784.

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In this thesis the development of a single pass non-dispersive infrared (NDIR) CO2 gas sensor with a path length of 30mm and with a lowest level CO2 detectivity of 20 ppm is described. A single pass NDIR CO2 sensor was developed in order to better understand the effect of the different sensor components i.e. the infrared source, thermal detector and the interference filter has on the NDIR CO2 gas sensor’s sensing ability for the industrial gas sensing application. . The study of various IR sources, detectors and filters has resulted in developing methodology that can be used for characterising IR sources detectors and filters from an application point of view. The obtained result from such application specific characterisation shows a more realistic measure of the NDIR CO2 sensor’s individual components performance characteristic, than what is quoted by the manufacturer of the IR sources, detectors and filters. The developed characterisation methodology is novel in its own right as such methodology currently to the author’s knowledge does not exist in the available literature. In order to better understand the effect of different infrared (IR) source, detectors and filters four different types of IR sources (microbulb, membrane type source, IR-LED source and ICX 2Dmetallo photonic crystal sources/detector pair), three different type of IR detectors Pyroelectric detectors, Thermopile detectors and 2D-metallo photonic crystal source/detector pair and two interference filters were investigated. A new amplitude modulation (AM) scheme was developed for driving the 2D-metallo photonic crystal device as a detector. This has resulted in an improvement of the 2D-metallo photonic crystal devices detectivity by a factor of 102 compared to the standard / conventional / recommended scheme. Demonstrations of the performance of the developed NDIR CO2 gas sensor are also shown in this thesis.
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Areal, Francisco Jose. "Production quotas, environmental goods and spatial dependence nder the CAP." Thesis, University of Reading, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.520110.

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Keimig, Kelsey Anne. "The Veracity of Self-Reported Criminal Records among NDSU Students." Thesis, North Dakota State University, 2013. https://hdl.handle.net/10365/27031.

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Campus safety and security are important concerns for colleges and universities. One way security is addressed is through utilization of self-report questions about criminal backgrounds during the admissions process. The current study evaluates this admissions policy by using a systematic random sample of 1,400 students to compare self-reported criminal backgrounds with criminal records listed in four online databases. Results indicate that two individuals within the sample failed to report their criminal backgrounds which included simple assault, burglary, theft, possession of controlled substance, and drug paraphernalia. While the failed reporting rate appears low, caution should be taken interpreting the results. A number of policy implications and directions for future research are discussed.
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Carlsson, Pernilla. "Cellular design of heparan sulfate : The NDST enzymes and their regulation." Doctoral thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9231.

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Heparan sulfate proteoglycans are proteins with long, unbranched heparan sulfate (HS) polysaccharide chains attached to them. They are found on cell surfaces and in basement membranes where they exert their action by interacting with a wide range of enzymes and signaling molecules and are thereby involved in a range of various processes both during embryonic development and in adult physiology.

A great part of the biological functionality of proteoglycans can be directly related to the polysaccharide part. HS chains display very variable sulfation patterns where highly sulfated regions are responsible for a large part of the biological activity. The biosynthesis of HS is a complex process in which a number of enzymes are involved. Better comprehension of how this process is regulated could reveal clues to how formation of HS sulfation patterns occurs, and thereby how HS functionality is controlled.

This thesis is focusing on regulation of one of the enzymes responsible for HS sulfation, glucosaminyl N-deacetylase/N-sulfotransferase (NDST), in an attempt to understand these mechanisms better. Different aspects of NDST regulation were studied in three projects:

I) “Heparin/heparan sulfate biosynthesis: Processive formation of N-sulfated domains”, where the sulfate donor PAPS is shown to influence the manner in which NDST modifies the substrate, affecting the domain structure of the polysaccharide.

II) “Heparan sulfate biosynthesis: Characterization of an NDST1 splice variant”, where a splice variant of NDST1 which appears to influence NDST1 protein levels and affect HS structure is described.

III) “Heparan sulfate biosynthesis in zebrafish: Five NDST genes with distinct expression patterns during embryonic development”, in which five zebrafish NDSTs were cloned and shown to be expressed in a temporally and spatially regulated manner.

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Ilehag, Rebecca. "Exploitation of Digital Surface Models from Optical Satellites for the Identification of Buildings in High Resolution SAR Imagery." Thesis, KTH, Geoinformatik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-191203.

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Interpreting a Synthetic Aperture Radar (SAR) image and detecting buildings can be a difficult task visually. In order acquire an overview of an area that has been affected by a disaster, such as an earthquake, SAR is useful due to its independence of weather conditions and the time of the day. GeoRaySAR, a simulator that has been developed by German Aerospace Center (DLR) and the Technical University of Munich (TUM), uses prior knowledge about the geometry extracted, from e.g. a Digital Surface Model (DSM), in order to identify buildings in high resolution SAR data. The simulator has previously utilized DSMs generated from Light Detection And Ranging (LiDAR) data with a vertical and horizontal resolution of 0.1 meters and 1 meter respectively without vegetation. However, DSMs of such high quality is not available everywhere. The objective of this thesis is to evaluate DSMs generated from high-resolution optical data for identifying building in high resolution SAR data in GeoRaySAR. Specifically, images from the spaceborne sensor WorldView-2 have been utilized in this thesis for the extraction of the geometry. The DSMs have been preprocessed in terms of removal of vegetation and reduction of the noise level. The SAR images, acquired from TerraSAR-X, were utilized in GeoRaySAR in order to detect buildings with the assistance of the DSM. An image size limitation that existed in GeoRaySAR has been addressed by adding tiling, which is based on the size of the study scene. Normalized DSM (nDSM) can be determined by calculating the difference between a DSM and a DTM. A nDSM, that received some adjustments, was used as input to GeoRaySAR and compared with the results from the normal DSM. Study areas in three cities, Munich, London and Istanbul, have been used to determine the advantages and limitations of GeoRaySAR and the impact the quality of the DSM has on the building extraction results. The results indicate that building extents can be detected with DSMs generated from optical data with various success, dependent on the quality of the DSM and on which incidence angle the SAR image was acquired in. The ability to interpret a scene increases with the usage of DSMs of higher quality and with SAR images taken in less steep incidence angles. The building DSM depends heavily on the quality of the DTM, but indicates good results and little data loss in study scenes where the DTM successfully removed all objects above ground.
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Hatlman, Petr. "Ekonomická strategie NDR v osmdesátých letech a její výsledky." Master's thesis, Vysoká škola ekonomická v Praze, 2007. http://www.nusl.cz/ntk/nusl-4484.

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V práci analyzuji hospodářskou politiku NDR v osmdesátých letech. Popisuji její příčiny, vývoj, záměry a důsledky. Politika NDR byla velmi centralistická. Pozici NDR můžeme charakterizovat třemi body. Za prvé ortodoxnost vůči Sovětskému svazu, za druhé sousedství s velmi vyspělou SRN a konečně za třetí silná ekonomická i politická závislost na SSSR. Během osmdesátých let musela NDR učinit opatření ke zmírnění dopadu cenových šoků způsobených zvýšením cen ropy. Zároveň musela reagovat na nespokojenost vlastních občanů. NDR se o to pokusila prostřednitvím sociálních opatření, které ale pro ni byly příliš drahé. Za této situace začal narůstat dluh, který NDR nebyla schopna snižovat.
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Bettoun, Audrey. "The NDR1 Kinase, a New Player in Oncogenic Signalling of Ral GTPases, Functions as a Linchpin Between Cancer Cell Survival and Death." Thesis, Paris 11, 2015. http://www.theses.fr/2015PA11T047.

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Des mutations du gène Ras jouent un rôle essentiel dans le développement tumoral. Les GTPases Ral , RalA et RalB, sont des effecteurs proximaux de l’oncogène Ras. RalA permet la croissance en absence de substrat et RalB est nécessaire à l'autophagie et à la résistance à l'apoptose des cellules cancéreuses. Cette thèse a pour objectif de clarifier les mécanismes moléculaires de la signalisation Ral impliqués dans l’oncogenèse dépendante des protéines Ras.Des criblages par double hydride ont été effectués par notre équipe et un interactome de Ral a été établi. Ce criblage a montré une interaction entre des protéines de la signalisation Ral et la protéine NDR1, une kinase pro-apoptotique appartenant à la voie " suppresseur de tumeur" Hippo. Le Projet 1 montre la régulation de NDR1 par la voie RalA-Exocyste- MAP4K4 en réponse au stress osmotique, oxydatif ou au traitement par le TNF-α. Dans cette voie, la kinase MAP4K4, un effecteur de RalA, via le complexe exocyste active directement NDR1. En outre, nous avons montré que la voie RalA-MAP4K4-NDR1 était nécessaire à l'apoptose déclenchée par le TNF-α ou par la surexpression de RASSF1A, suppresseur de tumeur appartenant à la voie Hippo. Nous avons donc montré que RalA a un rôle pro-apoptotique inattendue qui agit via la kinase NDR1, en plus de son rôle connu de proto-oncogène en aval de Ras.Le projet 2 montre que la protéine kinase NDR1 est un régulateur de l'autophagie. Des criblages par double hydride ont été effectués par notre équipe avec NDR1 comme appât et ont permis de montrer une interaction entre Beclin 1, une protéine majeure de l’autophagie, et NDR1. Nous avons montré que NDR1 était nécessaire à l'autophagie et à la formation des autophagosomes chez l'humain et la Drosophile. De plus, NDR1 est nécessaire à la formation du complexe Exo84 de l'exocyste, Beclin1 et RalB nécessaire à l'initiation de l'autophagie. Nous montrons également que RalB régule l'état d'activation de NDR 1 après induction de l'autophagie. En effet, en absence de RalB, nous avons observé une hyper - activation de NDR1 menant les cellules vers l'apoptose. Ainsi nous avons montré que NDR1 joue le rôle d'interrupteur favorisant l'autophagie ou favorisant l'apoptose suivant son état d'activation.Le projet 3 étudie l'implication de la voie RalGTPases-NDR1 dans l'oncogenèse dépendante de Ras et dissèque par quels mécanismes NDR1 y contribue
Constitutive Ras signalling is one of the most frequent oncogenic event in human cancers. Thus, it is imperative to identify new therapeutic options targeting downstream effectors of Ras signalling. Ras-like GTPases RalA and RalB are proximal effectors of oncogenic Ras. RalA was reported to support anchorage independent proliferation and RalB regulates autophagy and inhibits apoptosis of cancer cells. Ral proteins execute these functions via several direct effectors as the exocyst, an octameric complex originally identified as regulator of vesicles trafficking. The global goal of this PhD was to better decipher the molecular mechanisms underlying the functions of Ral GTPases in oncogenesis.To extend the Ral interactome, i.e. the protein-protein interaction network centered on Ral, we performed yeast-two hybrid screenings which led to the identification of the NDR1 kinase, belonging to the tumor suppressor Hippo pathway. NDR1 functions in oncogenesis were investigated in the context of three projects.In Project 1, we showed that NDR1-dependent apoptosis is regulated by a RalA/Exocyst/MAP4K4/NDR1 cascade. We reported that under osmotic or oxidative stresses or TNF-α treatment, the Ste20-like MAP4K4 kinase, an effector of RalA via the exocyst complex, directly activates NDR1. Moreover, we found that TNF-α treatment or overexpression of the tumor suppressor RASSF1A, which belongs to the Hippo pathway, leads to apoptosis through this RalA/Exocyst/MAP4K4/NDR1 pathway. This novel and unexpected pro-apoptotic role of RalA suggests that the RalA GTPase can positively signal in tumor suppressor pathways via the kinase NDR1, in addition to its proto-oncogenic role downstream of Ras. In Project 2, we described the NDR1 protein kinase as a conserved regulator of autophagy. Using NDR1 as bait in yeast two hybrid screens, we fished Beclin1, a key regulator of autophagy, and we validated the existence of a direct biochemical NDR1-Beclin1 interaction. We showed that NDR1promotes autophagosome formation in human cells and Drosophila larvae. Furthermore, we observed that NDR1 supports the interaction of the exocyst component Exo84 with Beclin1 and RalB, which is required to initiate autophagosome formation. Very interestingly, under prolonged autophagy, RalB depletion triggers hyperactivation of NDR1 resulting in NDR1-dependent apoptosis. Thus, it appears that the NDR1 kinase could act as a switch between autophagy (=survival) or apoptosis (=death), under the control of RalB. In Project 3, we addressed the role of the newly identified RalGTPases-NDR1axis in Ras - induced oncogenesis and tumorigenesis
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Books on the topic "NDSR"

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Tirta, Mark. Mitologjia ndër shqiptarë. Tiranë: Akademia e Shkencave e Shqipërisë Instituti i Kulturës Popullore, Dega e Etnologjisë, 2004.

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Tirta, Mark. Mitologjia ndër shqiptarë. Tiranë: Akademia e Shkencave e Shqipërisë Instituti i Kulturës Popullore, Dega e Etnologjisë, 2004.

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Bèye, Alioune Badara. Nder en flammes: Théâtre. Dakar: Nouvelle Editions Africaines du Sénégal, 1990.

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Hughes, Jeffrey F. NDS for NT. Foster City, CA: IDG Books Worldwide, 1998.

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Minaev, B. A. NDS: Aktualʹnye voprosy. Moskva: Glavbukh, 1999.

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Kronologjia iliro-shqiptare ndër shekuj. Tiranë: Instituti i Integrimit të Kulturës Shqiptare (IIKSH), 2011.

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Asani, Skender. Shqiptarët e Shkupit ndër shekuj--. Shkup: Shkupi, 2009.

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Mustafa, Avzi. Gjurmë ndër vite: (përmbledhje studimesh). Shkup: Botoi UISHM, 2014.

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Les lumières d'une cité: Ndar. Dakar, Sénégal: Presses universitaires de Dakar, 2003.

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Asani, Skender. Shqiptarët e Shkupit ndër shekuj--. Shkup: Shkupi, 2009.

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Book chapters on the topic "NDSR"

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Tiro, Jasmin, Simon J. Craddock Lee, Steven E. Lipshultz, Tracie L. Miller, James D. Wilkinson, Miriam A. Mestre, Barbara Resnick, et al. "Nutrition Data System for Research (NDSR)." In Encyclopedia of Behavioral Medicine, 1348–50. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1005-9_1683.

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Harnack, Lisa. "Nutrition Data System for Research (NDSR)." In Encyclopedia of Behavioral Medicine, 1519–20. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-39903-0_1683.

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Spalt, Johannes. "nder Klapptisch (englisch)." In Klapptische / Folding Tables, 61. Basel: Birkhäuser Basel, 1987. http://dx.doi.org/10.1007/978-3-0348-6207-3_25.

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Suski, W., and T. Palewski. "(NdS)1.23CrS2." In Pnictides and Chalcogenides II, 812–14. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/10713485_216.

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Suski, W., and T. Palewski. "(NdS)1.2NbS2." In Pnictides and Chalcogenides II, 817–19. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/10713485_218.

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Suski, W., and T. Palewski. "(NdS)1.16TaS2." In Pnictides and Chalcogenides II, 801–2. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/10713485_212.

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Suski, W., and T. Palewski. "(NdS)1.17TaS2." In Pnictides and Chalcogenides II, 803–4. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/10713485_213.

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Suski, W., and T. Palewski. "(NdS)1.18NbS2." In Pnictides and Chalcogenides II, 808–11. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/10713485_215.

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Suski, W., and T. Palewski. "(NdS)1.23VS2." In Pnictides and Chalcogenides II, 815–16. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/10713485_217.

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Hall, Dorothy K., and George A. Riggs. "Normalized-Difference Snow Index (NDSI)." In Encyclopedia of Earth Sciences Series, 779–80. Dordrecht: Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-90-481-2642-2_376.

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Conference papers on the topic "NDSR"

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Stolberg-Rohr, T., R. Buchner, A. Krishna, L. Munch, K. Pihl, J. S. Hansen, S. Tojaga, H. G. Moos, and J. M. Jensen. "NDIR humidity measurement." In 2011 IEEE Sensors. IEEE, 2011. http://dx.doi.org/10.1109/icsens.2011.6127237.

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Chen, Z., Y. Lim, and D. Brown. "Substitution of Ce for NdPr in melt-spun (NdPr)-Fe-B powders." In 2015 IEEE International Magnetics Conference (INTERMAG). IEEE, 2015. http://dx.doi.org/10.1109/intmag.2015.7156671.

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"nDS 2007." In 2007 International Workshop on Multidimensional (nD) Systems. IEEE, 2007. http://dx.doi.org/10.1109/nds.2007.4509524.

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Daly, Jim, Mark McNeal, Bill Gully, and Frank Swanson. "CW simulant detection by NDIR." In Optics East 2005, edited by Arthur J. SedlacekIII, Steven D. Christesen, Roger J. Combs, and Tuan Vo-Dinh. SPIE, 2005. http://dx.doi.org/10.1117/12.630888.

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"nDS 2007 Committees." In 2007 International Workshop on Multidimensional (nD) Systems. IEEE, 2007. http://dx.doi.org/10.1109/nds.2007.4509529.

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Wei-Lian Guo, Wei Wang, Ping-Juan Niu, Xiao-yun Li, Xin Yu, Lu-hong Mao, Hongwei Liu, Guang-hua Yang, and Rui-liang Song. "CMOS-NDR transistor." In 2008 9th International Conference on Solid-State and Integrated-Circuit Technology (ICSICT). IEEE, 2008. http://dx.doi.org/10.1109/icsict.2008.4734479.

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Chen, Shuo, Junwei Cao, and Lipeng Zhu. "NDSS: A Named Data Storage System." In 2015 International Conference on Cloud and Autonomic Computing (ICCAC). IEEE, 2015. http://dx.doi.org/10.1109/iccac.2015.12.

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Ayerden, N. P., Ger de Graaf, Peter Enoksson, and Reinoud F. Wolffenbuttel. "A highly miniaturized NDIR methane sensor." In SPIE Photonics Europe, edited by Hugo Thienpont, Jürgen Mohr, Hans Zappe, and Hirochika Nakajima. SPIE, 2016. http://dx.doi.org/10.1117/12.2225924.

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Strukov, Dmitri B., and Konstantin K. Likharev. "All-NDR crossbar logic." In 2011 IEEE 11th International Conference on Nanotechnology (IEEE-NANO). IEEE, 2011. http://dx.doi.org/10.1109/nano.2011.6144663.

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Zhang, Xue-Qing, Mark Chen, Robert Lam, Xiaoyang Xu, Eiji Osawa, and Dean Ho. "A Platform Approach to Gene Delivery via Surface Modified Nanodiamonds." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13340.

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Abstract:
The purpose of gene therapy is to introduce foreign genetic material into host cells to either supplement aberrant genes or to endow additional biological functions. To date, however, there has been only modest progress towards this goal, mainly due to the lack of safe, effective and broadly applicable delivery methods. Functional nanodiamonds (NDs) are rapidly emerging as promising platform carriers for next-generation therapeutics due to their innate biocompatibility, scalability, precise particle distribution, high surface area-to-volume ratio, near-spherical aspect ratio, and easily adaptable carbon surface for bioagent attachment. NDs have been functionalized with a range of therapeutics, proteins, antibodies, DNA, polymers, and other assorted biological agents. Furthermore, NDs are stable and dispersible in water, making them a promising and clinically important modality in improving the efficacy of the treatment of diseases and even some cancers at the molecular level. Mitochondrial function (MTT) and luminescent ATP production assays have demonstrated that NDs are not toxic to a wide variety of cell types. In this study, we functionalized NDs with amine groups via either covalent attachment of (3-aminopropyl) trimethoxysilane or surface immobilization of 800 Da low molecular weight polyethyleneimine (LMW PEI800) for plasmid DNA delivery. The latter delivery approach combines complementary characteristics of PEI800 and NDs to create a hybrid material that exhibits the high transfection efficiency of high molecular weight PEI, but without the inherent high cytotoxicity.
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Reports on the topic "NDSR"

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Pazuchanics, Peter David. U1A.03 NDSE Detector Design Review. Office of Scientific and Technical Information (OSTI), May 2020. http://dx.doi.org/10.2172/1623420.

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Boudjouk, Philip. Advancing Science Through Computation at NDSU (Final Report). Office of Scientific and Technical Information (OSTI), December 2018. http://dx.doi.org/10.2172/1523404.

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DeYoung, Anemarie, Vincent Yuan, George Morgan, Richard Anderson, Timothy Beller, Andrew Cooper, Theresa Cutler, et al. NDSE Static Series V & VI Test Results. Office of Scientific and Technical Information (OSTI), September 2020. http://dx.doi.org/10.2172/1660590.

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Mazumder, Pinaki, George I. Haddad, and Jack R. East. NDR Devices and their Digital Applications. Fort Belvoir, VA: Defense Technical Information Center, August 2000. http://dx.doi.org/10.21236/ada387626.

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Beller, T., M. Boswell, T. Cutler, A. DeYoung, D. Dinwiddie, T. Dugan, M. Fowler, et al. Primary Assessment Technologies FY2017 Milestone Report: NDSE Development Using DPF. Office of Scientific and Technical Information (OSTI), October 2018. http://dx.doi.org/10.2172/1477614.

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Lestone, John Paul, and Madison Theresa Andrews. Models for HEU objects in the NDSE IV and III series. Office of Scientific and Technical Information (OSTI), June 2019. http://dx.doi.org/10.2172/1529511.

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Montain, Scott J., Susan J. McGraw, Matther R. Ely, Frederick Dupont, and William J. Tharion. On-The-Move Nutrient Delivery System (NDS): User Acceptability of Rotary Flow Control Version. Fort Belvoir, VA: Defense Technical Information Center, April 2009. http://dx.doi.org/10.21236/ada496714.

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