Log in

Relevant bibliographies by topics / Nectin-1

Contents

Journal articles
Dissertations / Theses
Book chapters
Conference papers

Academic literature on the topic 'Nectin-1'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Nectin-1.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Nectin-1"

1

Yoshida, Toshiyuki, Yoshimi Takai, and Irma Thesleff. "Cooperation of Nectin-1 and Nectin-3 Is Required for Maintenance of Epidermal Stratification and Proper Hair Shaft Formation in the Mouse." Developmental Biology Journal 2014 (June 30, 2014): 1–12. http://dx.doi.org/10.1155/2014/432043.

Full text

Abstract:

Nectins constitute a family of four cell adhesion molecules which are localized on cell membrane. Mutations in NECTIN-1 gene cause the human ectodermal dysplasia syndrome (CLPED1) manifesting severe defects in skin and its appendages. However, nectin-1 null mutant mice have only a mild defect in epidermal stratification suggesting compensation by other nectins. We have analysed the epidermal and hair phenotypes of nectin-1; nectin-3 compound mutants. Epidermis was fragile and displayed severe defects in stratification, hair follicles were hypoplastic, and hair shaft structure was abnormal. Imm

APA, Harvard, Vancouver, ISO, and other styles

2

Struyf, Frank, Aileen E. Plate, and Patricia G. Spear. "Deletion of the Second Immunoglobulin-Like Domain of Nectin-1 Alters Its Intracellular Processing and Localization and Ability To Mediate Entry of Herpes Simplex Virus." Journal of Virology 79, no. 6 (2005): 3841–45. http://dx.doi.org/10.1128/jvi.79.6.3841-3845.2005.

Full text

Abstract:

ABSTRACT Nectin-1 is an immunoglobulin (Ig)-like entry receptor for herpes simplex virus (HSV). Like other nectins, nectin-1 forms dimers and mediates cell adhesion through interactions with other nectins. We constructed a second-domain deletion mutant of nectin-1 (nectin-1-Δ2) to examine the role of the second Ig-like domain in HSV entry. Nectin-1-Δ2 exhibited a severely reduced ability to mediate HSV entry and accumulated in the endoplasmic reticulum but retained the ability to interact with its HSV ligand, gD. The failure of nectin-1-Δ2 to mediate HSV entry probably resulted from its failur

APA, Harvard, Vancouver, ISO, and other styles

3

Struyf, Frank, Wanda M. Martinez, and Patricia G. Spear. "Mutations in the N-Terminal Domains of Nectin-1 and Nectin-2 Reveal Differences in Requirements for Entry of Various Alphaherpesviruses and for Nectin-Nectin Interactions." Journal of Virology 76, no. 24 (2002): 12940–50. http://dx.doi.org/10.1128/jvi.76.24.12940-12950.2002.

Full text

Abstract:

ABSTRACT Nectin-1 and nectin-2 are related molecules that can function with different specificities as entry receptors for mammalian alphaherpesviruses through interaction with viral glycoprotein D (gD). The normal function of members of the nectin family is to mediate cell-cell adhesion through homotypic and heterotypic nectin-nectin interactions in cadherin-based adherens junctions. We examined mutations in three equivalent regions of the N-terminal V-like domains of nectin-1 and nectin-2 to test the effects on entry of various alphaherpesviruses, nectin-nectin interactions, and interactions

APA, Harvard, Vancouver, ISO, and other styles

4

Krummenacher, Claude, Isabelle Baribaud, Roselyn J. Eisenberg, and Gary H. Cohen. "Cellular Localization of Nectin-1 and Glycoprotein D during Herpes Simplex Virus Infection." Journal of Virology 77, no. 16 (2003): 8985–99. http://dx.doi.org/10.1128/jvi.77.16.8985-8999.2003.

Full text

Abstract:

ABSTRACT During viral entry, herpes simplex virus (HSV) glycoprotein D (gD) interacts with a specific cellular receptor such as nectin-1 (PRR1/HveC/CD111) or the herpesvirus entry mediator A (HVEM/HveA). Nectin-1 is involved in cell-to-cell adhesion. It is located at adherens junctions, where it bridges cells through homophilic or heterophilic interactions with other nectins. Binding of HSV gD prevents nectin-1-mediated cell aggregation. Since HSV gD affects the natural function of nectin-1, we further investigated the effects of gD expression on nectin-1 during HSV infection or in transfected

APA, Harvard, Vancouver, ISO, and other styles

5

Brakeman, Paul R., Kathleen D. Liu, Kazuya Shimizu, Yoshimi Takai, and Keith E. Mostov. "Nectin proteins are expressed at early stages of nephrogenesis and play a role in renal epithelial cell morphogenesis." American Journal of Physiology-Renal Physiology 296, no. 3 (2009): F564—F574. http://dx.doi.org/10.1152/ajprenal.90328.2008.

Full text

Abstract:

Development of the nephron requires conversion of the metanephric mesenchyme into tubular epithelial structures with specifically organized intercellular junctions. The nectin proteins are a family of transmembrane proteins that dimerize to form intercellular junctional complexes between epithelial cells. In this study, we demonstrate that nectin junctions appear during the earliest stages of epithelial cell morphogenesis in the murine nephron concurrently with the transition of mesenchymal cells into epithelial cells. We have defined the role of nectin during epithelial cell morphogenesis by

APA, Harvard, Vancouver, ISO, and other styles

6

Patrusheva, Irina, Ludmila Perelygina, Ivan Torshin, Julia LeCher, and Julia Hilliard. "B Virus (Macacine Herpesvirus 1) Divergence: Variations in Glycoprotein D from Clinical and Laboratory Isolates Diversify Virus Entry Strategies." Journal of Virology 90, no. 20 (2016): 9420–32. http://dx.doi.org/10.1128/jvi.00799-16.

Full text

Abstract:

ABSTRACTB virus (Macacine herpesvirus 1) can cause deadly zoonotic disease in humans. Molecular mechanisms of B virus cell entry are poorly understood for both macaques and humans. Here we investigated the abilities of clinical B virus isolates to use entry receptors of herpes simplex viruses (HSV). We showed that resistant B78H1 cells became susceptible to B virus clinical strains upon expression of either human nectin-2 or nectin-1. Antibody against glycoprotein D (gD) protected these nectin-bearing cells from B virus infection, and a gD-negative recombinant B virus failed to enter these cel

APA, Harvard, Vancouver, ISO, and other styles

7

Chu, Carissa, Martin Sjöström, Emily A. Egusa, et al. "Heterogeneity in Nectin-4 expression across molecular subtypes of urothelial cancer mediates sensitivity to enfortumab vedotin." Journal of Clinical Oncology 39, no. 6_suppl (2021): 463. http://dx.doi.org/10.1200/jco.2021.39.6_suppl.463.

Full text

Abstract:

463 Background: Enfortumab vedotin (EV) is an antibody-drug conjugate (ADC) targeting Nectin-4 (encoded by the PVRL4/NECTIN4 gene ) approved for treatment-refractory metastatic urothelial cancer. Factors that mediate sensitivity or resistance to EV are unknown. In the present study, we sought to 1) examine heterogeneity of NECTIN4 gene expression across molecular subtypes of bladder cancer and 2) determine if Nectin-4 expression mediates EV sensitivity or resistance. Methods: NECTIN4 expression data from seven muscle-invasive bladder cancer clinical cohorts (n = 1912 total patients) were used

APA, Harvard, Vancouver, ISO, and other styles

8

Uchida, Hiroaki, Janet Chan, William F. Goins, et al. "A Double Mutation in Glycoprotein gB Compensates for Ineffective gD-Dependent Initiation of Herpes Simplex Virus Type 1 Infection." Journal of Virology 84, no. 23 (2010): 12200–12209. http://dx.doi.org/10.1128/jvi.01633-10.

Full text

Abstract:

ABSTRACT Herpes simplex virus (HSV) entry into cells is triggered by the binding of envelope glycoprotein D (gD) to a specific receptor, such as nectin-1 or herpesvirus entry mediator (HVEM), resulting in activation of the fusion effectors gB and gH and virus penetration. Here we report the identification of a hyperactive gB allele, D285N/A549T, selected by repeat passage of a gD mutant virus defective for nectin-1 binding through cells that express a gD-binding-impaired mutant nectin-1. The gB allele in a wild-type virus background enabled the use of other nectins as virus entry receptors. In

APA, Harvard, Vancouver, ISO, and other styles

9

Mizoguchi, Akira, Hiroyuki Nakanishi, Kazushi Kimura, et al. "Nectin." Journal of Cell Biology 156, no. 3 (2002): 555–65. http://dx.doi.org/10.1083/jcb.200103113.

Full text

Abstract:

The nectin–afadin system is a novel cell–cell adhesion system that organizes adherens junctions cooperatively with the cadherin–catenin system in epithelial cells. Nectin is an immunoglobulin-like adhesion molecule, and afadin is an actin filament–binding protein that connects nectin to the actin cytoskeleton. Nectin has four isoforms (-1, -2, -3, and -4). Each nectin forms a homo-cis-dimer followed by formation of a homo-trans-dimer, but nectin-3 furthermore forms a hetero-trans-dimer with nectin-1 or -2, and the formation of each hetero-trans-dimer is stronger than that of each homo-trans-di

APA, Harvard, Vancouver, ISO, and other styles

10

Krummenacher, Claude, Isabelle Baribaud, James F. Sanzo, Gary H. Cohen, and Roselyn J. Eisenberg. "Effects of Herpes Simplex Virus on Structure and Function of Nectin-1/HveC." Journal of Virology 76, no. 5 (2002): 2424–33. http://dx.doi.org/10.1128/jvi.76.5.2424-2433.2002.

Full text

Abstract:

ABSTRACT Herpes simplex virus (HSV) entry requires the interaction between the envelope glycoprotein D (gD) and a cellular receptor such as nectin-1 (also named herpesvirus entry mediator C [HveC]) or HveA/HVEM. Nectin-1 is a cell adhesion molecule found at adherens junctions associated with the cytoplasmic actin-binding protein afadin. Nectin-1 can act as its own ligand in a homotypic interaction to bridge cells together. We used a cell aggregation assay to map an adhesive functional site on nectin-1 and identify the effects of gD binding and HSV early infection on nectin-1 function. Soluble

APA, Harvard, Vancouver, ISO, and other styles

More sources

Dissertations / Theses on the topic "Nectin-1"

1

Rinehart, Erica Marie. "Inhibition of Nectin-1 and Herpes Virus Entry Mediator (HVEM) Using Monoclonal Antibodies Decreases HSV-1 Entry into Neuro-2A Cells." Wright State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=wright1438508507.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Ishino, Ryo. "Oncolytic virus therapy with HSV-1 for hematologic malignancies." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263570.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Sun, Jingru. "Nectin-1 is Degraded in Chlamydia trachomatis-Infected Genital Epithelial Cells and is Required for Herpes Simplex Virus Co-Infection-Induced C. trachomatis Persistence." Digital Commons @ East Tennessee State University, 2009. https://dc.etsu.edu/etd/1795.

Full text

Abstract:

The obligate intracellular bacterium Chlamydia trachomatis is the most common bacterial STD agent in the US. This bacterium has a unique biphasic developmental cycle in which the infectious elementary body (EB) infects a host mucosal epithelial cell and differentiates into the replicative form (the reticulate body or RB) within a modified vacuole called an inclusion. The RB later divides and develops back into an EB and is released, perpetuating the infectious cycle. When developing chlamydiae are exposed to unfavorable environmental conditions, they deviate from the normal developmental cycle

APA, Harvard, Vancouver, ISO, and other styles

4

Slade, Jessica A. "In Vitro and In Vivo Characterization of Chlamydia and HSV Co-infection." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etd/3026.

Full text

Abstract:

The obligate intracellular bacterium, Chlamydia trachomatis, and Herpes Simplex Virus Type-2 (HSV-2) are the leading sexually transmitted pathogens in the world. These infections are usually asymptomatic and clinically mild, but complications can be severe. Reports of dual detection of Chlamydia and HSV within the genital tracts of humans led our laboratory to develop an in vitro Chlamydia/HSV co-infection model. Little is known regarding the specific pathogenesis of Chlamydia and HSV co-infections, but HSV-super-infection of Chlamydia-infected cells caused the chlamydiae to deviate from their

APA, Harvard, Vancouver, ISO, and other styles

5

Labani, Motlagh Alireza. "Immune modulation in serous epithelial ovarian cancer : focus on the role of tumor-derived exosomes." Doctoral thesis, Umeå universitet, Institutionen för klinisk mikrobiologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-138264.

Full text

Abstract:

Serous epithelial ovarian cancer (EOC) is a potent suppressor of the immune defense. Here, we studied interactions between EOC and the immune system that lead to escape from tumor immune surveillance. We explored: 1) tumor escape from cytotoxicity by exosome-mediated modulation of the NK-cell receptors NKG2D and DNAM-1; 2) cytokine mRNA profiles in the EOC microenvironment and peripheral blood and their role in the suppression of the anti-tumor immune responses; 3) expression of long non-coding (lnc) RNAs in EOC tumors and exosomes. We found that EOC-secreted exosomes carried MICA/B and ULBP1-

APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "Nectin-1"

1

Mori, Masahiro, Yoshiyuki Rikitake, Kenji Mandai, and Yoshimi Takai. "Roles of Nectins and Nectin-Like Molecules in the Nervous System." In Advances in Neurobiology. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-8090-7_5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Heflik, Włodzimierz. "Problem „świadomości w ogóle” u Kanta i Jaspersa." In Karl Jaspers. Filozofia wieczysta - filozofia czasu. Wydawnictwo Naukowe Uniwersytetu Pedagogicznego w Krakowie, 2021. http://dx.doi.org/10.24917/9788380846616.9.

Full text

Abstract:

In his book on Kant, Jaspers equates consciousness-as-such with transcenden- tal apperception. Within the framework of Kantian philosophy, consciousness as transcendental apperception is treated as: (1) original synthetic unity, and (2) a form of consciousness or form of presentation. I first consider the con- nections between consciousness-as-such and the transcendental subject, the transcendental I and the noumenal I. I then turn to an analysis of Jaspers’ treatment of consciousness-as-such. He understands this term to mean “the encompassing that is the entity that I am (self)”. Consciousness-as-such is considered in two ways, i.e. through a description of (1) what it is in itself, and (2) its relationship with other kinds of encompassing. I limit my discussion to the relationship between consciousness and two main kinds of encompassing, that is Existenz and reason. I focus on the concept of consciousness from the following perspectives: (1) as a form, (2) the role of Existenz as a factor filling in the empty form of consciousness, and (3) as illuminating consciousness through reason.

APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Nectin-1"

1

Fuchs, Bryan C., Toshihiko Kuroda, Suguru Yamada, et al. "Abstract 598: EMT and nectin-1 mediate sensitivity to HSV-1 oncolysis in human HCC cell lines." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-598.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Richards, Paige, Neha Alaparthy, Simranjit Kaur, and Claude Krummenacher. "Assessing the binding of nectin-1 and CD96 in human cells to investigate how herpes simplex virus evades the innate immune system." In Rowan University Biology Student Symposium. Rowan University Libraries, 2020. http://dx.doi.org/10.31986/issn.2689-0690_rdw.buss.1006.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Müller, N., and U. Velten. "FIBRONECTIN CONTENTS AND LEVELS IN BLOOD COMPONENTS DURING STORAGE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644155.

Full text

Abstract:

Fibronectin has been proposed to have an antithrombotic effect, protecting against platelet and fibrinogen consumption after injury. For the supply of platelets the possibility of extending platelet storage is important forthe management of platelet logistics. This study was designed to determine the effect of storage on the contents and levels of fibro-nectin (FN) in whole blood and components suchas packed RBCs, PRPs and platelet concentrates (PC) in two different plastics. For care of critically ill patients the FN present in components often used in large amounts could supplement the use o

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!