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Dissertations / Theses on the topic 'Needlets'

Author: Grafiati

Published: 4 June 2021

Last updated: 13 February 2022

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1

Pham, Ngoc Thanh Mai. "Problèmes inverses et analyse en ondelettes adaptées." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2009. http://tel.archives-ouvertes.fr/tel-00439112.

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Nous abordons l'étude de deux problèmes inverses, le problème des moments de Hausdorff et celui de la déconvolution sur la sphère ainsi qu'un problème de régression en design aléatoire. Le problème des moments de Hausdorff consiste à estimer une densité de probabilité à partir d'une séquence de moments bruités. Nous établissons une borne supérieure pour notre estimateur ainsi qu'une borne inférieure pour la vitesse de convergence, démontrant ainsi que notre estimateur converge à la vitesse optimale pour les classes de régularité de type Sobolev. Quant au problème de déconvolution sur la sphère, nous proposons un nouvel algorithme qui combine la méthode SVD traditionnelle et une procédure de seuillage dans la base des Needlets sphériques. Nous donnons une borne supérieure en perte Lp et menons une étude numérique qui montre des résultats fort prometteurs. Le problème de la régression en design aléatoire est abordé sous le prisme bayésien et sur la base des ondelettes déformées. Nous considérons deux scenarios de modèles a priori faisant intervenir des gaussiennes à faible et à grande variance et fournissons des bornes supérieures pour l'estimateur de la médiane a posteriori. Nous menons aussi une étude numérique qui révèle de bonnes performances numériques.

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2

Monnier, Jean-Baptiste. "Quelques contributions en classification, régression et étude d'un problème inverse en finance." Phd thesis, Université Paris-Diderot - Paris VII, 2011. http://tel.archives-ouvertes.fr/tel-00650930.

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On s'intéresse aux problèmes de régression, classification et à un problème inverse en finance. Nous abordons dans un premier temps le problème de régression en design aléatoire à valeurs dans un espace euclidien et dont la loi admet une densité inconnue. Nous montrons qu'il est possible d'élaborer une stratégie d'estimation optimale par projections localisées sur une analyse multi-résolution. Cette méthode originale offre un avantage calculatoire sur les méthodes d'estimation à noyau traditionnellement utilisées dans un tel contexte. On montre par la même occasion que le classifieur plug-in construit sur cette nouvelle procédure est optimal. De plus, il hérite des avantages calculatoires mentionnés plus haut, ce qui s'avère être un atout crucial dans de nombreuses applications. On se tourne ensuite vers le problème de régression en design aléatoire uniformément distribué sur l'hyper-sphère et on montre comment le tight frame de needlets permet de généraliser les méthodes traditionnelles de régression en ondelettes à ce nouveau contexte. On s'intéresse finalement au problème d'estimation de la densité risque-neutre à partir des prix d'options cotés sur les marchés. On exhibe une décomposition en valeurs singulières explicite d'opérateurs de prix restreints et on montre qu'elle permet d'élaborer une méthode d'estimation de la densité risque-neutre qui repose sur la résolution d'un simple programme quadratique.

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3

Busillo, Eric. "Characterization of plastic hypodermic needles." Thesis, Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/26584.

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Thesis (M. S.)--Mechanical Engineering, Georgia Institute of Technology, 2009.
Committee Chair: Colton, Jonathan; Committee Member: Ku, David; Committee Member: Prausnitz, Mark. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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4

Stellman, Jeffrey Taylor. "Production, development, and characterization of plastic hypodermic needles." Thesis, Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/29748.

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Thesis (M. S.)--Mechanical Engineering, Georgia Institute of Technology, 2009.
Committee Chair: Dr. Jonathan S. Colton; Committee Member: Dr. Mark R. Prausnitz; Committee Member: Dr. Rudolph L. Gleason. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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5

Andersson, Alexandra. "Den stickrädda patienten." Thesis, Högskolan i Gävle, Avdelningen för hälso- och vårdvetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-23256.

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Bakgrund: Studier visa att ca 10 % av världens befolkning lider av stickrädsla. Konsekvenser för person som känner stickrädsla är ångest och oro samt undvikande av medicinska procedurer som innefattar injektioner. Detta kan leda till hälsoproblem för individen och i värsta fall leda till att personen undviker all hälso- och sjukvård. Det är viktig att sjuksköterskan har kunskaper om vilka omvårdnadshandlingar som kan lindra lidande för patienten. Syfte: Syftet med denna litteraturstudie var att utifrån ett sjuksköterskeperspektiv belysa omvårdnadsåtgärder som kan förbygga stickrädsla hos barn. Syftet var också att beskriva urvalsgrupperna i de inkluderade artiklarna. Metod: En litteraturstudie där resultatet av 12 artiklar granskats, analyserats och sammanställts. Sökningar utfördes i databaserna PubMed, CINAHL samt PsycINFO. Huvudresultat: I resultatet framkom att miljöns utformning är viktig då barn ska få injektioner och att barn, behövde var väl förbered på vad som skulle hända innan nålinförandet. I resultatet framkom också att även mindre barn har möjlighet att tillgodogöra sig utbildning om nålrelaterade procedurer. Att anpassa tiden efter barnets behov var viktigt och att det är barnets behov som skulle få styra vården. Distraktion under själva nålinförandet visade på minskad rädsla hos barnen men att det bästa var dock om distraktion inte behövdes. Slutsatser: Vårdmiljöns utformning är viktig när barn ska få ett nålinföranden och sjuksköterska kan minska känslan av sjukhus eller vårdcentral genom att anpassa miljön och att tillhanda ha distraherande leksaker. Det är viktigt att barn vet vad som skulle hända vid ett nålinförande och även mindre barn kan tillgodogöra sig utbildning om nålrelaterade procedurer samt förstå vikten av dem. Sjuksköterskan kan genom att anpassa besökstiden efter barnets behov och bekräfta barnets känslor minska oro och rädsla hos stickrädda barn.
Background: Studies show that about 10% of the world population suffer from needle fear. Consequences for the person with this phobia who knows needle fear is anxiety and avoidance of medical procedures involving injections. This can lead to health problems for the individual and in the worst case lead to the person avoiding all healthcare. It is important that the nurse has knowledge of the factors that can lead to needle fear and what the nursing interventions that can alleviate the suffering of the patient. Aim: The purpose of this study was to highlight nurses nursing care measures required to preclude the fear of needles in children. The aim was also to describe the selection groups in the included articles. Method: A literature review in which the results of the 12 articles reviewed, analyzed and compiled. Searches were conducted in PubMed, CINAHL and PsycINFO. Main Results: The result showed that the environment's design is important as children get injections, and how well the child was prepared for needle insertion. The result showed that even small children have the opportunity to benefit from training on needle insertion procedures. Adjusting the time it takes for a baby and a toddler to adapt must be allowed to steer healthcare. Distraction was used as a method before the needle insertion but that the best were of distraction was not needed. Conclusions: The environment´s design is important as children get injections and nurse can reduce the feeling of a hospital or clinic by adapting the environment and provide for distracting toys. It is important that children know what would happen at the needle insertion procedure and even smaller children can benefit from education about needle injection procedures and understand the importance of them. The nurse can by adjusting the session time for the child's needs and validate the child's feelings reduce anxiety and fear of the needle fearing children.

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6

Montanari, Piero. "Needles in haystack of tweets." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amslaurea.unibo.it/5389/.

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7

McAllister, Devin Vincent. "Microfabricated needles for transdermal drug delivery." Diss., Georgia Institute of Technology, 2000. http://hdl.handle.net/1853/11031.

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8

Foulaadvand, M. Ebrahim, Azadeh Saiidi, and Mohsen Yarifard. "A 2D system of hard needles." Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-198127.

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9

Shek, Ka To. "Hot embossing-injection molding and puncture characterization of polymer hypodermic needle /." View abstract or full-text, 2007. http://library.ust.hk/cgi/db/thesis.pl?MECH%202007%20SHEK.

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10

Kianirad, Hoda. "Contact poling of RKTP with silicon needles." Thesis, KTH, Fysik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-120593.

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11

Lee, Diana Sution. "O sonho americano em Pins and Needles." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/8/8147/tde-02022018-093129/.

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Esta dissertação tem como objetivo a análise do sonho americano em Pins and Needles. Criada na cidade de Nova Iorque em 1937 por dramaturgos ligados ao teatro de esquerda, a peça espalhou-se pelos Estados Unidos, angariou trabalhadores para os sindicatos, influenciou grupos amadores de teatro, parodiou shows populares e satirizou eventos da Grande Depressão, mostrando um humor incomparável. Nos quesitos histórico e cultural, a peça mais popular da década de 1930 é única, por ser representante do apogeu do Movimento Teatral dos Trabalhadores Americanos e da Frente Popular durante o Novo Acordo. Através do que denominamos de os quatro eixos ideológicos do sonho americano, estudamos como o texto dramatúrgico de Pins and Needles, na sua mistura de agitprop e revista musical, questiona se haveria de fato para os trabalhadores igualdade de oportunidades, direito à vida, liberdade e busca da felicidade, (possibilidade de) atuação e mobilidade social como recompensa do trabalho árduo, ajudando-nos a reconceptualizar a ideologia da nação norte-americana.
This dissertation aims at analyzing the American dream in Pins and Needles. Originated in the city of New York in 1937 by playwrights connected to the theater of the left, the play spread throughout the United States, attracted workers to the labor unions, influenced amateur theater groups, parodied popular shows and satirized Great Depression events, by using an incomparable humor. In the historical and cultural requisites, the most popular play in the 1930s is unique, by being the representative of the apogee of the American Workers Theater Movement and of the Popular Front during the New Deal. By observing what we call the four ideological axes of the American dream, we study how the dramaturgical text of Pins and Needles, in its blend of agitprop and musical revue, questions if really there were equality of opportunities, right to Life, Liberty, and the pursuit of Happiness, agency and social mobility as a result of hard work to the workers, helping us to reconceptualize the ideology of the American nation.

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12

Al, Kafri Yaser. "Metals uptake in pine needles (Pinus nigra)." Thesis, Örebro universitet, Institutionen för naturvetenskap och teknik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-84446.

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13

Liao, Xiaochun. "Investigation of needle-tissue interaction during ultrasonic needle intervention." Thesis, University of Dundee, 2015. https://discovery.dundee.ac.uk/en/studentTheses/d84b1d53-3249-4ca0-ac2a-4aa683a6fe37.

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14

Tomashuk, Timothy A. "A comparison of atmospheric PAHs in pine needles and high-volume sampler filters in the dayton metro area." Wright State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=wright1278966475.

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15

Bernardes, Mariana. "Robot assisted steering of flexible needles for percutaneous procedures." Thesis, Montpellier 2, 2012. http://www.theses.fr/2012MON20145.

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Les travaux de cette thèse proposent une nouvelle approche pour le guidage assisté par robots d'aiguilles flexibles pour des procédures percutanées. La méthode est basée sur l'utilisation d'une rotation de l'aiguille avec un rapport cyclique variable pour réaliser une insertion avec des arcs de rayons de courbure différents. Elle combine un retour visuel avec une stratégie de planification adaptative pour compenser les incertitudes du système et les perturbations. Par rapport aux approches présentées précédemment dans la littérature, la stratégie de planification en boucle fermée est adaptée à des scènes dynamiques qui présentent des changements de position des obstacles et de la cible. Cette approche a été implémentée sur un système robotique et les résultats obtenus in vitro confirment tout l'intérêt de cette technique
This thesis proposes a robot-assisted approach for automatic steering of flexible beveled needles in percutaneous procedures. The method uses duty-cycled rotation of the needle to perform insertion with arcs of adjustable curvature, and combines closed-loop imaging feedback with an intraoperative motion replanning strategy to compensate for system uncertainties and disturbances. Differently from previous approaches, the closed-loop replanning strategy is suitable for dynamic scenes that present changes of obstacles and target positions. Indeed, we implemented the proposed system using a robotic manipulator, and the results obtained from in vitro tests confirmed the viability of our method

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16

Schalau, Jeff, and Deborah Young. "Pinyon Needle Scale." College of Agriculture and Life Sciences, University of Arizona (Tucson, AZ), 2003. http://hdl.handle.net/10150/144793.

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2 pp.
Other forest health publications
Pinyon needle scale (Matsucoccus acalyptus) are very small (0.5 mm) sucking insects that feed on pinyon, singleleaf pinyon, and foxtail pines in the southwestern United States. These insects can be effectively controlled using an integrated approach which includes sanitation, supplemental irrigation, and pesticides.

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17

Schalau, Jeff. "Pinyon Needle Scale." College of Agriculture and Life Sciences, University of Arizona (Tucson, AZ), 2011. http://hdl.handle.net/10150/239597.

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18

Holloway, David. "Of pens and needles: Reading the traditional in Tanizaki's "Shisei"." Connect to online resource, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1442935.

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19

Foulaadvand, M. Ebrahim, Azadeh Saiidi, and Mohsen Yarifard. "A 2D system of hard needles: event oriented molecular dynamics." Diffusion fundamentals 24 (2015) 14, S. 1, 2015. https://ul.qucosa.de/id/qucosa%3A14528.

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20

Kukkola, E. (Eija). "Effects of copper and nickel on subarctic Scots pine needles." Doctoral thesis, University of Oulu, 1999. http://urn.fi/urn:isbn:9514253701.

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Abstract Three different studies were conducted to elucidate the effects of copper (Cu) and nickel (Ni) on Scots pine needles. One was the Monchegorsk smelter emission gradient study on the Kola Peninsula, Russia, the second was the 3-year seedling and 6-year adult tree low-level CuNi and acid rain (H2SO4 at pH 3) irrigation study at Kevo, Finland. In the third study seedlings were exposed to Cu and Ni for a one season in Oulu, Finland. Ni accumulated efficiently in needles, and this accumulation was seen in each of the different studies. The Cu concentrations remained low in needles, except near the Monchegorsk smelters. The addition of Ni together with Cu in Oulu seemed to enhance the accumulation of Ni into the needles of Scots pine seedlings. Plasmolysis may be related to both drought and the Ni treatment, as observed in Oulu, because plasmolysis was statistically more abundant in the 15 mg Ni kg-1 dry soil treated needles than in other treatments except in 25 mg Ni kg-1 dry soil. Cu induced lipid peroxidation of chloroplast membranes was visible under transmission electron microscope (TEM) as light colored, swollen thylakoids in chloroplasts near the Monchegorsk smeltersand also in needles exposed to 25 Ni+50 Cu mg kg-1 in soil in Oulu. Some year to year variation in the frost hardening process was seen in metal and acid treated needles, which may have caused the maximum frost hardiness level drop after CuNi, pH3 and CuNi/pH3 treatments. Root growth was increased by 5 mg Ni kg-1 dry soil in soil in Oulu, but 15 mg Ni kg-1 dry soil Ni in soil decreased root growth and increased root tip dieback. 25 Ni+50 Cu mg kg-1 dry soil in soil markedly decreased root growth. The proportion of oxidized glutathione in Cu-treated needles was smaller than in Ni-treated needles, but roots had higher peroxidase activity levels. However, Ni seemed to cause more oxidative stress to seedlings than copper.

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21

Martanto, Wijaya. "Microinjection Into Skin Using Microneedles." Diss., Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/11645.

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The development of microneedles that penetrate the skin barrier, but are small enough not to stimulate nerves, has the potential to deliver drugs across skin in a painless way. Controlled injection by convective flow into skin using hollow microneedles, however, has remained a challenge. To address this challenge, the goals of this study were (i) to provide experimental measurements coupled with numerical simulations to quantitatively describe fluid mechanics of flow within microneedles over a range of experimental conditions and needle geometries, (ii) to demonstrate and study the effects of diffusion-based delivery of insulin to diabetic rats in vivo using solid and hollow microneedles and (iii) to determine the effect of experimental parameters on microinfusion through hollow microneedles into skin to optimize drug delivery protocols and identify rate-limiting barriers to flow. Experimentally, we quantified the relationship between pressure drop and flow rate through microneedles as a function of fluid viscosity and microneedle length, diameter, and cone half-angle. Microneedle tip diameter and taper angle were the primary controlling parameters for flow through conically tapered microneedles as shown by numerical simulations. Flow rates over a range of 1.4 56 l/s were achieved through microneedles (in the absence of skin) with pressure drops in the range of 4.6 196.5 kPa. This work also studied the use of solid and hollow microneedle arrays to insert into the skin of diabetic animals for transdermal delivery of insulin. Blood glucose levels dropped by as much as 80% in diabetic rats in vivo. Larger drops in blood glucose level and larger plasma insulin concentrations were shown due to higher donor solution insulin concentration, shorter microneedles insertion time and fewer repeated insertions. The final scope of this work was to determine the effect of microneedle geometry and infusion protocols on microinfusion flow rate into skin in vitro. Infusion flow rates ranged from 21 to 1130 l/h was demonstrated using glass microneedles. The presence of a bevel at the microneedle tip, larger retraction distance and insertion depth, larger infusion pressure and the presence of hyaluronidase led to larger infusion flow rates.

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22

Wisely, Colin David. "Genealogy of the needle." Thesis, Manchester Metropolitan University, 2014. http://e-space.mmu.ac.uk/332938/.

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The Foucault influenced Opium and the People (1981) has generated considerable interest in its dealing with the construction of the medico-legal persona of the addict and has come to dominate many different interdisciplinary areas of study. An important critique of this work can be found in Henry Bryan Spear’s response to criticisms of civil servant Sir Malcolm Delevigne. These points reveal the operation of the repressive hypothesis in drugs discourse. The limitations of Opium and the People call for a fuller genealogical analysis of the subject of addiction. Discipline and Punish (1991a) and History of Sexuality Part One (1998) are the publications closely associated with the genealogical period of Foucault’s thought. The earlier publication of History of Madness (2006a) and Foucault’s lecture series also enable further interesting insights into the hermeneutics of addiction. One minor area for Opium and the People is the emergence of injection drug use and this phenomenon represents the focus of this thesis. It is through the story of the hypodermic syringe that we can see with more detail how the hermeneutic processes that were intended to eradicate opium use for pleasure ultimately led to the spread of intravenous injection. Beginning with the structural elision of the pain controlling from the pleasure producing elements of opium we can see the unexpected consequences of utopianism in the form of an outbreak of intravenous knowledge in the 1920s New York City following the imposition of a total prohibition on opiates. Through the tale of the hypodermic we can see the creation of the modern day ‘Tom Thumb horror’, the influence of confessional technology and the importance of resistance to bio-technico power in the creation of the phenomenon of intravenous injection drug use. In Part One: ‘Self and Truths’ I outline the methodological project, the role of Friedrich Nietzsche’s thought upon Foucault’s idea of history. Here we will establish the core elements of Foucault’s genealogical method with a specific emphasis on the importance of the repressive hypothesis as outlined in The History of Sexuality Part One (1998) for the creation of the pejorative archetype of the junkie. In Part Two: ‘Structure, Monsters and Poets’ the importance of Descartes’ thought on the experimental enquiry into the control of pain are considered along with the inability to include the euphoria that opium induces. The importance of the History of Madness (2006a) is developed in this section as a key problem in our comprehension of the prohibitive response to the pleasures that are associated with opium. This section considers the importance of juridical process in the creation of the ‘Tom Thumb horror’, a process whereby legal case law is linked to broader medical and legal processes, thus enabling the creation of medico-legal persona that are related to specific jurisprudence. The importance of the creation of the idea of inebriety and the link developed between opium and alcohol enables us to observe this ongoing process. I consider the role of Thomas DeQuincey and Samuel Taylor Coleridge in the creation of the opium eater and the mysterious process whereby these musings became established as legal and medical facts. The significance of DeQuincey’s Stoic method of introspection and its impact on the creation of a new medical condition is developed. In Part Three: ‘The Needle, Inebriety and Resistance’, I explore the invention of the hypodermic and its spread across the globe. I look at the ongoing legal process that led to the abolition and the creation of an industry around a new medico-legal identity of the opium eater. The decline of the opium trade and the eventual prohibition are set against a paradoxical response of a small proportion of opium users that provides clear empirical evidence of a phenomenon that Foucault termed resistance. The importance of the relationship between hermeneutics, public policy and resistance in the creation of the conditions that led to the spread of the knowledge of intravenous injection forms the basis of the main conclusion of this study. In the final section I explore the implications of this study in the present-day and consider a Cynic alternative to the Stoic view of opium addiction.

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23

Fick, Cornelia. "Eye of a needle." Thesis, Rhodes University, 2016. http://hdl.handle.net/10962/d1021210.

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Most of my stories are about interpersonal relationships between the sexes, as well as intrapersonal processes, such as growing old. I have a deep connection to such themes because of my background as a general nurse and midwife; meeting too many abused women in hospitals, and the broader community. Because patterns of abuse tend to become invisible, I use experimental forms of storytelling as well as sharp, ironic and dark humour as a way to make this side of life more visible. My reading has shown me how experimental forms can render seemingly timeless or ageless topics in a fresh, vital way.

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Hue, Eriksson Karin, and Gülfidan Kalkan. "Det är bara ett litet stick. Nålfobi hos ungdomar och vuxna : En litteraturöversikt." Thesis, Högskolan Väst, Avd för vårdvetenskap på grundnivå, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-6375.

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Background Adolescents and adults suffering from needle phobia have an unreasonable fear of needles that leads to negative experiences if they do not get the support they need. Negative experiences lead to patients avoiding health care, or these experiences affect important aspects of life. The suffering that a patient experiences may be obvious to some, but others hide it, and then it will be more difficult to detect. The nurse's role is to recognize the suffering and its different reactions in order to alleviate and prevent unnecessary suffering of the patient. AimThe purpose of this study was to describe about young people's and adults' experiences of having needle phobias. Method A literature review methodology, using eight quantitative articles and one qualitative article relevant for the aim of study.The analysis was done by comparing the similarities and differences from the result's content.Afterwards the most important parts in the result was coded to build categories and themes. Results Patients with needle phobias experience many different physical reactions such aspain, vasovagal reaction and other reactions during venipuncture, injections or just by seeing a needle. Long waiting times worsened the experience and strengthened the response. Patients experience more anxiety and fear because of their previous negative experiences and because of the medical environment. Experiences and reactions differ between ages, gender and level of education. Conclusion Patients with needle phobias have different experiences and reactions vary from person to person. Nurses on care institutions need more knowledge about patient'sexperiencesof needle phobias to better support and ease the suffering that afflicts the patients.

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Kim, Hoyeon. "Fabrication and Analysis of Plastic Hypodermic Needles by Micro Injection Molding." Thesis, Georgia Institute of Technology, 2004. http://hdl.handle.net/1853/5221.

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This thesis explores the analysis and fabrication of plastic hypodermic needles. The hypotheses for this work are that replacing metal hypodermic needles with plastic ones will reduce or eliminate the possibility of the second-hand infections from needle sticks and unsterlized reuse and will be more cost and time efficient to recycle. The most critical structural failure mode for plastic needles is buckling due to their shape (thin walled hollow column). The consideration of buckling is critical to avoid structural failure and to ensure reliability for medical applications. The buckling strength of a cannula is analyzed by analytic (Euler buckling theory) and finite element analysis (FEA) methods. A 22 gage needle model (OD 0.7mm, ID 0.4mm, Length 12.7mm) was analyzed. Euler buckling theory was used to calculate the critical buckling load. Numerical approaches using finite element analyses showed very similar results with analytic results. A skin model was introduced to simulate boundary conditions in the numerical approaches. To verify the results of the analyses, cannulas with the same cross-sectional dimensions were fabricated using a micro injection molding technique. To make the parts hollow, a core assembly of straightened wire was used. Using the tip of a 22 gage needle, cannulas with the inverse shape of an actual hypodermic needle were made. The structural (buckling) characteristics of cannulas were measured by a force-displacement testing machine. When buckling occurred, an arch shape was visible and there was an abrupt change in the load plot. Test results showed the relation between the needles length and the buckling load, which was similar to that predicted by Euler buckling theory. However, test values were 60% of the theoretical or analytical results. Several reasons to explain these discrepancies can be found. The first is that an unexpected bending moment resulted from an eccentric loading due to installation off-center to the center of the testing machine or to the oblique insertion. A cannula that was initially bent during ejection from the mold can add an unexpected bending moment. The quality control of cannulas can be another reason. Bent or misaligned core wires produce eccentric cannulas, and the thinner wall section can buckle or initiate fracture more easily. The last reason may be that Euler buckling theory is not fully valid in short cannula, because the axial stress reaches yield stress before buckling occurs. Inelastic deformation occurs (i.e., the modulus is reduced) during compression in short cannula. The Johnson column formula is introduced to explain this situation. Especially for the nylon nanocomposite material tested, a loss in modulus due to moisture absorption may be another explanation for the discrepancies.

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Park, Jung-Hwan. "Polymeric microneedles for transdermal drug delivery." Diss., Available online, Georgia Institute of Technology, 2004:, 2004. http://etd.gatech.edu/theses/available/etd-06072004-131324/unrestricted/park%5Fjung-hwan%5F200405%5Fphd.pdf.

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27

Hopkins, Alexandra Elizabeth. "Suffering needless pain : a Delphi study of pain management for nurse education." Thesis, University of Wolverhampton, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394005.

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Leifland, Karin. "Comparison of stereotactic fine needle aspiration biopsy and core needle biopsy in breast lesions /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-912-9.

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Syvertsen, Rolf Anders. "Tetrahedral mesh for needle insertion." Thesis, Norwegian University of Science and Technology, Department of Computer and Information Science, 2007. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-8791.

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This is a Master’s thesis in how to make a tetrahedral mesh for use in a needle insertion simulator. It also describes how it is possible to make the simulator, and how to improve it to make it as realistic as possible. The medical simulator uses a haptic device, a haptic scene graph and a FEM for realistic soft tissue deformation and interaction. In this project a tetrahedral mesh is created from a polygon model, and then the mesh has been loaded into the HaptX haptic scene graph. The objects in the mesh have been made as different haptic objects, and then they have got a simple haptic surface to make it possible to touch them. There has not been implemented any code for the Hybrid Condensed FEM that has been described.

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Liu, John (John Hsiao-Yung). "Needle-free injection nozzle geometry." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/119770.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2018.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 155-158).
The development of needle-free injection (NFI) delivery systems has become increasingly important because of the advantages it affords such as increased patient acceptability, enhanced occupational safety for health providers, safe disposal, and increased speed of mass vaccination in the face of pandemic influenza or bioterror emergencies. Jet injection, wherein drug is propelled at high pressure through a narrow orifice to create a high-speed fluid jet sufficient to penetrate tissue, is one of several needle-free methods for administration of drug. Despite promising research and development, few efforts study the fluid dynamics of NFI and address the role of nozzle design. This thesis presents the development of nozzle geometries and the optimization of the nozzle shape for NFI applications. We develop nozzle geometries that produce non-axial jets to expand the range of NFI delivery modalities. A rigid, compact, multi-piece ampoule is designed and fabricated as a platform to conveniently house different nozzle inserts one at a time to offer increased jet consistency and functional flexibility. Two nozzle geometries that respectively produce radial jets and intersecting jets are designed and fabricated. Through high-speed imaging and injection into tissue analog and ex vivo porcine tissue, we demonstrate the utility of these nozzles for a range of injection applications including intradermal, intratympanic, and traditional uses. The presented ampoule is more successful than a commercial jet injection ampoule in adhering to desired position and velocity trajectories and the energy efficiencies of jet ejections are compared. Using computational fluid dynamics, we explore how the geometric elements of nozzle shape affect viscous loss and cavitation within the nozzle, the jet's velocity field at the orifice exit, and nozzle wall structural integrity. These insights inform the creation of an objective function and a class of curves used for nozzle shape optimization. A novel nozzle manufacturing technique is developed using a combination of micro-drilling and sink electrical discharge machining to fabricate axisymmetric nozzle orifices. Optically clear planar nozzles are developed and fabricated to image and compare the cavitation within the interior of nozzles of different shapes. The optimized nozzle demonstrates at least a 7% increase in mechanical efficiency and a decrease in cavitation of two orders of magnitude from a commercial jet injection nozzle.
by John Liu.
Ph. D.

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31

Glennon, Heather Mary. "Effect of copper oxide needles on gastrointestinal parasites in grazing meat goats." NCSU, 2004. http://www.lib.ncsu.edu/theses/available/etd-04142004-152506/.

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Gastrointestinal (GI) parasitism may be the most challenging health problem associated with raising goats. Two trials were conducted to evaluate the effects of copper (Cu) oxide needles (CuON) on trichostrongylid parasites in grazing Boer-cross yearling goats. In trial 1, 18 does and 18 wethers (40 kg BW) were stratified by fecal egg counts (FEC) and sex, and sorted into 6 groups of 6 animals in a randomized complete block design (RCBD) with 3 replications. On d 0, control (CTL) goats received a combined dose of fenbendazole (10 mg/kg BW) and levamisole (11 mg/kg BW) whereas treated goats received a 5 g CuON bolus. In trial 2, 45 wethers (48 kg BW) were stratified by FEC and randomly assigned to 1 of 9 groups of 5 animals each in a RCBD with 3 replications. Treatments were 0 g (CTL), 5 g, or 10 g of a CuON bolus. In both trials, goats were rotationally grazed in separate bermudagrass/crabgrass plots. Fecal and blood samples were taken every 7 d. Liver samples and the abomasum (trial 2 only) were taken when animals were sacrificed on d 77 (trial 1) and d 59, 60 and 63 (trial 2). In trial 1, FEC were lower (P < .06) for CuON goats on d 31 (2,426 vs 4,115 eggs/g feces). Packed cell volume was higher in CTL goats on d 67 (32.2 vs 27.7%, P < .02) and d 74 (28.8 vs 24.6%, P < .03). Total protein was also higher in CTL goats on d 53 (6.6 vs 6.0 g/dL, P < .03) and d 74 (6.4 vs 5.7 g/dL, P < .01). Liver Cu concentrations were higher (P < .044) in CuON goats (395 vs 138 mg/kg DM). Liver lesions and plasma Cu concentrations did not differ. In trial 2, FEC were higher (P < .01) in CTL than 10g CuON goats on d 14 (CTL: 4117; 5 g: 2795; 10 g: 1768 eggs/g feces). Goats on 10 g CuON had lower (P < .04) PCV on d 14 (CTL: 31.3; 5 g: 32.4; 10 g: 29.1%). Liver Cu concentrations increased linearly (P < .01) (CTL: 92; 5 g: 296; 10 g: 386 mg/kg DM). Total protein, plasma Cu concentrations, liver lesions and number of Haemonchus contortus or Trichostrongylus axei found in the abomasum were similar. Although CuON have the potential to become part of an integrated internal parasite program, additional research is needed before CuON can be recommended as a safe and effective anthelmintic.

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32

Hellström, Anna. "Uptake of airborne organic pollutants in pine needles : geographical and seasonal variation /." Uppsala : Dept. of Environmental Assassment, Swedish Univ. of Agricultural Sciences, 2003. http://epsilon.slu.se/a402.pdf.

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33

Hellström, Anna. "Uptake of airborne organic pollutants in pine needles : geographical and seasonal variations /." Uppsala : Swedish University of Agricultural Sciences, 2003. http://diss-epsilon.slu.se/archive/00000275/.

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Thesis (doctoral)--Swedish University of Agricultural Sciences, 2003.
Thesis documentation sheet inserted. Appendix reproduces four papers and manuscripts co-authored with others. Includes bibliographical references. Also issued electronically via World Wide Web in PDF format; online version lacks appendix.

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34

Heffner, Heather Ann. "Analysis of post-use hypodermic needle medical waste disposal." Thesis, Available online, Georgia Institute of Technology, 2004:, 2004. http://etd.gatech.edu/theses/available/etd-06072004-131158/unrestricted/heffner%5Fheather%5Fa%5F200405%5Fms.pdf.

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35

Davis, Shawn Paul. "Hollow microneedles for molecular transport across skin." Diss., Georgia Institute of Technology, 2004. http://hdl.handle.net/1853/8055.

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36

McTiernan, Kevin B. "The effect of climate on the decomposition of chemical constituents of tree litters." Thesis, Lancaster University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266812.

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Davis, Shawn Paul. "Hollow microneedles for molecular transport across skin." Available online, Georgia Institute of Technology, 2004:, 2003. http://etd.gatech.edu/theses/available/etd-06072004-131118/unrestricted/davis%5Fshawn%5Fp%5F200305%5Fphd.pdf.

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38

Sofokleous, P. D. "Investigation of single-needle and multi-needle electrohydrodynamic processes for the preparation of advanced bioproducts." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1434331/.

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Polymeric products with micro/nano dimensions have attracted substantial interest in recent years and it has been shown that complex structures can be generated from solid and encapsulated particles/fibres. Although several techniques have been used to engineer these products their disadvantages such as high processing costs and the need for solvents and additives that are not fully biocompatible, lead to poor controllability and biological stability of the bioactive agents. In contrast, electrohydrodynamic (EHD) and co-axial EHD (CEHD) processes are simple and inexpensive techniques that can produce solid and multicomponent products on the nano/micro scale in a single step and under ambient conditions. The parameters affecting the formation of these products using the EHD process are well-known but on the other hand studies using the CEHD process are limited; hence the first objective of this work was to investigate the different physical and mechanical processing parameters affecting the encapsulated fibres produced by the CEHD process. The second objective of this study was to use a single needle EHD system to prepare and investigate the release of amoxicillin from electrospun polymeric fibrous wound dressing patches for wound healing and infection control. This work establishes a potential method of producing drug-loaded polymeric micro fibres with a controlled release behaviour that can be use in wound care industry. The third objective of this study was to improve the EHD and CEHD processes by designing and constructing an advance multi-needle assembly device where the needle height displacement between the needle tips could be controlled, which was then inserted in a portable handheld electrohydrodynamic spray gun. The spray gun was tested successfully for its ability to engineer solid and encapsulated products. The fourth and last objective was to investigate how the needle height displacement between their needle tips, in a two needle co-axial EHD assembly system, is affecting the production of encapsulated particles/fibres and the percentage number (n%) of the encapsulated products formed. By successfully achieving these objectives it was proved that there are still ways to improve the EHD and CEHD techniques in order to expand their use in many other technological and pharmaceutical fields.

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39

Sutterfield, Ashley. "Microbial translocation of needle-free injection enhanced beef strip loins as compared with traditional needle injection." Thesis, Manhattan, Kan. : Kansas State University, 2009. http://hdl.handle.net/2097/1230.

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40

Ankawi, Brett. "The Effects of Implementation Intentions on Responses to Needle Images in those with High Needle Fear." Ohio University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1426861213.

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41

Gerlach, Bryce Mark. "Incidence and severity of Arcanobacterium pyogenes injection site abscesses with needle and needle-free injection methods." Thesis, Kansas State University, 2010. http://hdl.handle.net/2097/4644.

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Master of Science
Department of Animal Sciences and Industry
Terry A. Houser
Nursery age pigs (n=198) were used to evaluate the difference in the occurrence of injection site abscesses between needle-free jet injection and conventional needle-and-syringe injection systems. Pigs were fed for 21 d prior to treatment administration to acclimate the pigs to the environment of the Kansas State University Segregated Early Weaning (SEW) unit. On d 21 each pig was injected with aluminum hydroxide adjuvant in the neck and ham with needle-free jet injection (Pulse Needle-Free Systems, Lenexa, KS) and conventional needle-and-syringe injection. Needle-free and conventional needle-and-syringe injections were randomly assigned to pig side yielding a total of 396 injections per treatment with a total of 792 injections sites. Immediately prior to injection, the external surface of the injection sites were contaminated with an inoculum of Arcanobacterium pyogenes, a bacterium commonly associated with livestock abscesses. The pigs were then fed for a period of 27 or 28 d. On d 27 or d 28 the pigs were humanely euthanized and sent to the Kansas State Veterinary Diagnostics Laboratory where necropsies were performed and the injection sites harvested for histopathological evaluation. The needle-free jet injection system was associated with more injection site abscesses than the conventional needle-and-syringe injection method for both neck (P=0.0625) and ham (P=0.0313) injection sites. Twelve abscesses were found at injection sites administered via needle-free jet injection method while only 1 abscess was found with the conventional needle-and-syringe injection method. 5 abscesses were found at the neck injection sites and 8 abscesses were found at ham injection sites. There were no significant differences seen in tissue granulation resulting from reaction to the adjuvant. In summary, the implementation of needle-free jet injection systems in market hog production will be beneficial to eliminate needles and needle fragments in meat products but, when in the presence of Arcanobacterium pyogenes, it may increase the occurrence of injection site abscesses in pork carcasses that will need to be trimmed in pork processing plants. Although more abscesses were associated with needle-free jet injection, their occurrence was observed at a very low rate given that all injection sites were intentionally contaminated prior to injection.

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42

Harling, Stalker L. Lynda. "Wool and needles in my casket : knitting as habit among rural Newfoundland women /." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ55508.pdf.

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43

Yu, Tony S. (Tony Sheung). "Solidification in a thin liquid film : growing Alq₃ needles via methanol-vapor annealing." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/65167.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2011.
This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student submitted PDF version of thesis.
Includes bibliographical references (p. 135-145).
Organic electronics hold the promise of low-cost, flexible, large-area electronic and optoelectronic devices. In order to improve the performance of these devices, it is vital to control the morphology (e.g., the crystallinity) of these thin films. This thesis examines how solvent-vapor annealing of thin, amorphous films of Alq₃-i.e., tris-(8-hydroxyquinoline) aluminum-promotes the growth of single-crystal needles; we explore this system through experiments, modeling, and analytical scaling laws. The first part of this thesis describes the growth of single-crystal Alq₃ needles from amorphous, thin films of Alq₃ annealed in methanol vapor. Micrographs captured during annealing reveal needle lengths that grow like power laws, such that Lneedle ~ t[gamma]. We show that the growth exponent, [gamma], decreases when the thickness of the Alq₃ films is increased. In addition to needle growth, the fluid films exhibited dewetting and coarsening behavior: the initially-uniform films broke up into small drops that coalesced to form larger drops. In the second part of this thesis, we develop a mathematical model describing these morphological changes-both drop formation and needle growth-during solvent-vapor annealing. The evolution of the fluid films is modeled by a lubrication equation, and a convection-diffusion equation captures the transport of Alq3 and methanol within the films. We define a dimensionless transport coefficient, [alpha], which describes the relative effects of diffusion and coarsening-driven convection. Numerical simulations based on this 1D model reproduce the films evolution observed in experiments. The final part of this thesis describes scaling laws that govern needle growth. For large [alpha]-values, needle growth matched the theory of 1D, diffusion-driven solidification, such that [gamma]1/2. For low [alpha]-values, flow driven by drop collapses-i.e., coarsening-controls the growth of needles. Within this regime, we identify two cases: needles that were small compared to the typical drop size, and those that were large. For small needles, [gamma]-> 2/5, and for large needles, [gamma]-> 0:29. These scaling laws provide a simple physical picture of needle growth and match numerical simulations.
by Tony S. Yu.
Ph.D.

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44

Inaba, Hiroshi. "Structural design of cell-penetrating protein needles toward development of intracellular delivery systems." 京都大学 (Kyoto University), 2015. http://hdl.handle.net/2433/195979.

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45

Luo, Chwan-Yau 1960. "Mechanisms of mechanical (needle) transmyocardial revascularization." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80325.

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Transmyocardial Revascularization (TMR), a procedure for enhancing myocardial perfusion, is used to treat patients with refractory angina. The mechanism remains elusive. We tested the hypotheses that (a) needle TMR induces nitric oxide synthase (NOS) enzyme, which is potentially capable of causing vasodilatation to augment blood flow; (b) that needle TMR can recruit smooth muscle cells for vessel development (arteriogenesis) in the late phase of TMR; and (c) that needle TMR improves myocardial regional blood flow in the early and late phases of TMR under either rest or stress conditions. We conclude that, both experimentally and clinically, the validity of TMR as an effective therapy for myocardial ischemia remains questionable and that the placebo effect in TMR treatment cannot be excluded.

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46

Draper, Katharine J. "Automatic needle localization in ultrasound images." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ39818.pdf.

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47

Liu, John (John Hsiao-Yung). "Intradermal needle-free powdered drug injection." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/74993.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2012.
Cataloged from PDF version of thesis.
Includes bibliographical references (p. 65-67).
This thesis presents a new method for needle-free powdered drug injection. The design, construction, and testing of a bench-top helium-powered device capable of delivering powder to controllable depths within the dermis is presented. This device uses a jet of gas undergoing choked flow to entrain powder and subsequently penetrates through the skin for delivery of the powder. Different nozzle designs and orifice geometries are also explored. In vitro injection of polymer beads (1-5 [mu]im in diameter) into porcine tissue demonstrate the device's capability of drug delivery to depths of 260 to 5000 [mu]m. The jet parameters of nozzle orifice diameter and applied pressure are shown to affect injection depth, shape, and success rate. The presented device has the potential to be implemented with stabilized formulations of vaccines to address the cold chain problem-the cost and risk of transporting temperature sensitive vaccines to developing countries.
by John Liu.
S.M.

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48

Shergold, Oliver Alexander. "The mechanics of needle-free injection." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.616047.

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49

Jiang, Ninghao. "Ocular drug delivery using microneedles." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2006. http://hdl.handle.net/1853/19796.

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Thesis (Ph.D)--Chemical Engineering, Georgia Institute of Technology, 2007.
Committee Chair: Prausnitz, Mark R.; Committee Member: Allen, Mark; Committee Member: Edelhauser, Henry; Committee Member: Geroski, Dayle; Committee Member: Nickerson, John; Committee Member: Sambanis, Athanassios.

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50

Gunn, Bernard. "Detection of needle wear in an automated sewing process." Thesis, Georgia Institute of Technology, 1991. http://hdl.handle.net/1853/8533.

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