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1

Kane, J. "Commentary: Consensus Statement on Negative Symptoms." Schizophrenia Bulletin 32, no. 2 (October 12, 2005): 223–24. http://dx.doi.org/10.1093/schbul/sbj010.

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2

Conway, Michael, Roberto Difazio, and François Bonneville. "Consensus and Causal Attributions for Negative Affect." Journal of Social Psychology 130, no. 3 (June 1990): 375–84. http://dx.doi.org/10.1080/00224545.1990.9924593.

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3

Kirschbaum, Charles. "Painful Consensus: negative ties and dyadic agreement." Academy of Management Proceedings 2012, no. 1 (July 2012): 13016. http://dx.doi.org/10.5465/ambpp.2012.13016abstract.

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4

Kirkpatrick, B., W. S. Fenton, W. T. Carpenter, and S. R. Marder. "The NIMH-MATRICS Consensus Statement on Negative Symptoms." Schizophrenia Bulletin 32, no. 2 (February 15, 2006): 214–19. http://dx.doi.org/10.1093/schbul/sbj053.

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5

Zhang, Yao-feng, Hong-ye Duan, and Zhi-lin Geng. "Evolutionary Mechanism of Frangibility in Social Consensus System Based on Negative Emotions Spread." Complexity 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/4037049.

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To study the social consensus system under the spread of negative emotions, the nonlinear emergence model of frangibility of social consensus system is established based on Multiagent method, and effects of emotions spread frequency, opinion leaders, and shielding behavior of government on the frangibility of social consensus system are revealed. The simulation results show that the low-frequency negative emotions spread is better than the high-frequency one for reducing the frangibility of social consensus system. Low-frequency negative emotions spread will lead to the group polarization, while high frequency will lead to the collapse of system. The joining of opinion leaders who are with negative emotions can promote the frangibility of social consensus system, and collapse speed of social consensus system tends to increase with the influence of opinion leaders. Shielding behavior of government cannot effectively block the spread of negative emotions. On the contrary, it will enhance the frangibility of social consensus system.
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6

Wang, Jianan, Alexander Lanzon, and Ian R. Petersen. "Robust Output Feedback Consensus for Networked Negative-Imaginary Systems." IEEE Transactions on Automatic Control 60, no. 9 (September 2015): 2547–52. http://dx.doi.org/10.1109/tac.2015.2395472.

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7

Wang, Xiao Ling, Housheng Su, Michael Z. Q. Chen, Xiao Fan Wang, and Guanrong Chen. "Reaching Non-Negative Edge Consensus of Networked Dynamical Systems." IEEE Transactions on Cybernetics 48, no. 9 (September 2018): 2712–22. http://dx.doi.org/10.1109/tcyb.2017.2748990.

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8

Willy, Christian, Animesh Agarwal, Charles A. Andersen, Giorgio De Santis, Allen Gabriel, Onnen Grauhan, Omar M. Guerra, et al. "Closed incision negative pressure therapy: international multidisciplinary consensus recommendations." International Wound Journal 14, no. 2 (May 12, 2016): 385–98. http://dx.doi.org/10.1111/iwj.12612.

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9

KUCHKOVSKY, V. "BLOCKCHAIN SYSTEM CONSENSUS ALGORITHMS." HERALD OF KHMELNYTSKYI NATIONAL UNIVERSITY 297, no. 3 (July 2, 2021): 30–33. http://dx.doi.org/10.31891/2307-5732-2021-297-3-30-33.

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This article describes the main consensus algorithms, their positive and negative aspects. Consensus in the general sense means a way to come to an agreement. In the blockchain, which is a decentralized system that does not have a single governing body, various algorithms have been developed to achieve consensus. In a blockchain network, it does not matter whether the system participants trust each other or not. They must agree on certain principles of work that will apply to everyone. And this is a direct function of the consensus mechanism. Algorithms are described and an example of solving this problem is given, namely the problem of choosing a consensus for future systems. An example of using multiple consensuses in blockchain networks is given. Such consensuses as Proof of Work (PoW), proof of Capacity (PoC), proof of Authority (PoA), proof of activity (PoAA), proof of Importance (PoI), proof of Burn (PoB), proof of Stake (PoS) are described, as well as its subspecies: Leased Proof-of-Stake (LPoS), Delegated Proof-of-Stake (DPoS). Many different nuances about the mixed type of consensus are described and examples of such cryptocurrencies and systems are given. The subtleties of mining for each consensus are described. Examples of hash functions, masternodes, nodes, algorithms, as well as key features of certain cryptocurrencies with mixed consensus are given. It is concluded that the choice of consensus for building systems based on blockchain.
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10

Payton, Jonathan D. "The logical form of negative action sentences." Canadian Journal of Philosophy 46, no. 6 (December 2016): 855–76. http://dx.doi.org/10.1080/00455091.2016.1193406.

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AbstractIt is typically assumed that actions are events, but there is a growing consensus that negative actions, like omissions and refrainments, are not events, but absences thereof. If so, then we must either deny the obvious, that we can exercise our agency by omitting and refrainment, or give up on event-based theories of agency. I trace the consensus to the assumption that negative action sentences are negative-existentials, and argue that this is false. The best analysis of negative action sentences treats them as quantifying over omissions and refrainments, conceived of as events.
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11

Kim, Paul J., Christopher E. Attinger, Thomas Constantine, Brett D. Crist, Elizabeth Faust, Christoph R. Hirche, Lawrence A. Lavery, et al. "Negative pressure wound therapy with instillation: International consensus guidelines update." International Wound Journal 17, no. 1 (October 30, 2019): 174–86. http://dx.doi.org/10.1111/iwj.13254.

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12

de Luna, Antonio Bayés, Wojciech Zareba, Miquel Fiol, Kjell Nikus, Yochai Birnbaum, Rafael Baranowski, Diego Goldwasser, et al. "Negative T Wave in Ischemic Heart Disease: A Consensus Article." Annals of Noninvasive Electrocardiology 19, no. 5 (September 2014): 426–41. http://dx.doi.org/10.1111/anec.12193.

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13

Bonadonna, Gianni. "Adjuvant chemotherapy in node-negative breast cancer NCI consensus conference." European Journal of Cancer and Clinical Oncology 26, no. 7 (January 1990): 844–45. http://dx.doi.org/10.1016/0277-5379(90)90168-s.

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14

Suwandee, Sasithorn, Jiraporn Surachartkumtonkun, and Aurathai Lertwannawit. "EWOM firestorm: young consumers and online community." Young Consumers 21, no. 1 (September 20, 2019): 1–15. http://dx.doi.org/10.1108/yc-03-2019-0982.

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Purpose This study aims to examine the influence of homophily in an online community and the effect of electronic word of mouth (eWOM) consensus on young consumers’ attitudes. Design/methodology/approach This study implemented an experimental research design using a two (low/high homophily) × two (low/high eWOM consensus) mixed factorial design. This study explores young consumers’ changes in brand attitude after encountering negative eWOM. Findings The results indicate that a high consensus of negative eWOM among online community members leads to significant changes in attitude, while a low consensus of negative eWOM does not produce such an effect. Negative eWOM from either high or low homophilous sources produces significant changes in attitude. There are significant attitude changes when a strong consensus of negative eWOM is received from a source with a high level of homophily. Research limitations/implications Service failures in offline service settings lead to the dissemination of negative eWOM on social media. To handle and prevent social media crises, researchers should understand online crises antecedents relating to information characteristics i.e. eWOM consensus and characteristics of online community members to evaluate the crises impact. Brands should monitor tone and dialogue of online community member on social media to remedy and diminish any damage done to their brand image from negative eWOM. Originality/value This study contributes to the application of social network theory by understanding the role of nodes on negative eWOM effect in social media.
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15

Anan'in, O., R. Khaitkulov, and D. Shestakov. "Washington Consensus: Landscape after Battles." World Economy and International Relations, no. 12 (2010): 15–27. http://dx.doi.org/10.20542/0131-2227-2010-12-15-27.

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The essence of the Washington Consensus, its implementation in 1990s – early 2000s, and its influence on Russia's economic policy development during this period is thoroughly examined in the article. Both positive and negative aspects of the Consensus, as well as the role of John Williamson, the English economist who formulated these economic policy guidelines for the Latin American countries, further extended to all developing countries, are specified.
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16

Hazinski, MF, TJ Iberti, NR MacIntyre, MM Parker, D. Tribett, S. Prion, and H. Chmel. "Epidemiology, pathophysiology and clinical presentation of gram-negative sepsis." American Journal of Critical Care 2, no. 3 (May 1, 1993): 224–35. http://dx.doi.org/10.4037/ajcc1993.2.3.224.

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OBJECTIVE: To review the epidemiology and pathophysiology of gram-negative sepsis and the new consensus terminology describing the clinical signs of sepsis. DATA SOURCES: Review of the medical literature and compiled data from animal and clinical trials. PARTICIPANTS: Members of the Society of Critical Care Medicine, American College of Chest Physicians and American Association of Critical-Care Nurses with expertise on the subject of sepsis and its complications. RESULTS: Preconference and general sessions were offered at the National Teaching Institutes of the American Association of Critical-Care Nurses, with the goal of clarifying the epidemiology, risk factors and pathophysiology of gram-negative sepsis. In addition, current terminology and new (1992) consensus terminology describing the clinical signs of sepsis were presented. Special emphasis was placed on the role of the healthcare provider in the prevention and recognition of sepsis and the role of the septic mediators in the septic cascade. CONCLUSIONS: If the incidence of sepsis is to be reduced, the healthcare provider must be aware of the risk factors for sepsis and methods of reducing nosocomial infections. A thorough understanding of the role of mediators and consensus terminology used to describe sepsis, severe sepsis, septic shock and multiple organ dysfunction syndrome is necessary to recognize early or progressive signs of sepsis and to initiate state-of-the-art therapy.
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17

Miller, Myrna M., Keith W. Jarosinski, and Karel A. Schat. "Positive and Negative Regulation of Chicken Anemia Virus Transcription." Journal of Virology 79, no. 5 (March 1, 2005): 2859–68. http://dx.doi.org/10.1128/jvi.79.5.2859-2868.2005.

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ABSTRACT Chicken anemia virus (CAV) is a small circular single-stranded DNA virus with a single promoter-enhancer region containing four consensus cyclic AMP response element sequences (AGCTCA), which are similar to the estrogen response element (ERE) consensus half-sites (A)GGTCA. These sequences are arranged as direct repeats, an arrangement that can be recognized by members of the nuclear receptor superfamily. Transient-transfection assays which use a short CAV promoter construct that ended at the transcription start site and drive expression of enhanced green fluorescent protein (EGFP) showed high basal activity in DF-1, LMH, LMH/2A, and primary theca and granulosa cells. The estrogen receptor-enhanced cell line, LMH/2A, had significantly greater expression than LMH cells, and this expression was significantly increased with estrogen treatment. A long promoter construct which included GGTCA-like sequences downstream of the first CAV protein translation start site was found to have significantly less EGFP expression in DF-1 cells than the short promoter, which was largely due to decreased RNA transcription. DNA-protein binding assays indicated that proteins recognizing a consensus ERE palindrome also bind GGTCA-like sequences in the CAV promoter. Estrogen receptor and other members of the nuclear receptor superfamily may provide a mechanism to regulate CAV activity in situations of low virus copy number.
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18

Rangarao, R., B. K. Smruti, K. Singh, A. Gupta, S. Batra, R. K. Choudhary, A. Gupta, et al. "Practical consensus recommendations on management of triple-negative metastatic breast cancer." South Asian Journal of Cancer 07, no. 02 (April 2018): 127–31. http://dx.doi.org/10.4103/sajc.sajc_118_18.

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AbstractPatients with breast cancer along with metastatic estrogen and progesterone receptor (ER/PR)- and human epidermal growth factor receptor 2 (HER2)-negative tumors are referred to as having metastatic triple-negative breast cancer (mTNBC) disease. Resistance to current standard therapies such as anthracyclines or taxanes limits the available options for previously treated patients with metastatic TNBC to a small number of non-cross-resistant regimens, and there is currently no preferred standard chemotherapy. Clinical experience suggests that many women with triple-negative metastatic breast cancer (MBC) relapse quickly. Expert oncologist discussed about new chemotherapeutic strategies and agents used in treatment of mTNBC and the expert group used data from published literature, practical experience and opinion of a large group of academic oncologists to arrive at this practical consensus recommendations for the benefit of community oncologists.
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19

Wang, Jianan, Alexander Lanzon, and Ian R. Petersen. "A Robust Output Feedback Consensus Protocol for Networked Negative-Imaginary Systems." IFAC Proceedings Volumes 47, no. 3 (2014): 2878–83. http://dx.doi.org/10.3182/20140824-6-za-1003.00716.

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20

Alphs, L. "An Industry Perspective on the NIMH Consensus Statement on Negative Symptoms." Schizophrenia Bulletin 32, no. 2 (February 9, 2006): 225–30. http://dx.doi.org/10.1093/schbul/sbj056.

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21

Rozental, Alexander, Gerhard Andersson, Johanna Boettcher, David Daniel Ebert, Pim Cuijpers, Christine Knaevelsrud, Brjánn Ljótsson, Viktor Kaldo, Nickolai Titov, and Per Carlbring. "Consensus statement on defining and measuring negative effects of Internet interventions." Internet Interventions 1, no. 1 (March 2014): 12–19. http://dx.doi.org/10.1016/j.invent.2014.02.001.

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22

Zheng, Chunlei, and Rong Xu. "Molecular subtyping of Alzheimer’s disease with consensus non-negative matrix factorization." PLOS ONE 16, no. 5 (May 20, 2021): e0250278. http://dx.doi.org/10.1371/journal.pone.0250278.

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Alzheimer’s disease (AD) is a heterogeneous disease and exhibits diverse clinical presentations and disease progression. Some pathological and anatomical subtypes have been proposed. However, these subtypes provide a limited mechanistic understanding for AD. Leveraging gene expression data of 222 AD patients from The Religious Orders Study and Memory and Aging Project (ROSMAP) Study, we identified two AD molecular subtypes (synaptic type and inflammatory type) using consensus non-negative matrix factorization (NMF). Synaptic type is characterized by disrupted synaptic vesicle priming and recycling and synaptic plasticity. Inflammatory type is characterized by disrupted IL2, interferon alpha and gamma pathways. The two AD molecular subtypes were validated using independent data from Gene Expression Omnibus. We further demonstrated that the two molecular subtypes are associated with APOE genotypes, with synaptic type more prevalent in AD patients with E3E4 genotype and inflammatory type more prevalent in AD patients with E3E3 genotype (p = 0.031). In addition, two molecular subtypes are differentially represented in male and female AD, with synaptic type more prevalent in male and inflammatory type in female patients (p = 0.051). Identification of AD molecular subtypes has potential in facilitating disease mechanism understanding, clinical trial design, drug discovery, and precision medicine for AD.
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23

Shi, Kanghong, Igor G. Vladimirov, and Ian R. Petersen. "Robust Output Feedback Consensus for Networked Identical Nonlinear Negative-Imaginary Systems." IFAC-PapersOnLine 54, no. 9 (2021): 239–44. http://dx.doi.org/10.1016/j.ifacol.2021.06.081.

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24

Elghazaly, Hesham, Hope S. Rugo, Hamdy A. Azim, Sandra M. Swain, Banu Arun, Matti Aapro, Edith A. Perez, et al. "Breast-Gynaecological & Immuno-Oncology International Cancer Conference (BGICC) Consensus and Recommendations for the Management of Triple-Negative Breast Cancer." Cancers 13, no. 9 (May 8, 2021): 2262. http://dx.doi.org/10.3390/cancers13092262.

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Background: The management of patients with triple-negative breast cancer (TNBC) is challenging with several controversies and unmet needs. During the 12th Breast-Gynaecological & Immuno-oncology International Cancer Conference (BGICC) Egypt, 2020, a panel of 35 breast cancer experts from 13 countries voted on consensus guidelines for the clinical management of TNBC. The consensus was subsequently updated based on the most recent data evolved lately. Methods: A consensus conference approach adapted from the American Society of Clinical Oncology (ASCO) was utilized. The panellists voted anonymously on each question, and a consensus was achieved when ≥75% of voters selected an answer. The final consensus was later circulated to the panellists for critical revision of important intellectual content. Results and conclusion: These recommendations represent the available clinical evidence and expert opinion when evidence is scarce. The percentage of the consensus votes, levels of evidence and grades of recommendation are presented for each statement. The consensus covered all the aspects of TNBC management starting from defining TNBC to the management of metastatic disease and highlighted the rapidly evolving landscape in this field. Consensus was reached in 70% of the statements (35/50). In addition, areas of warranted research were identified to guide future prospective clinical trials.
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25

Ariizumi, K., H. Takahashi, M. Nakamura, and H. Ariga. "Negative transcriptional regulatory element that functions in embryonal carcinoma cells." Molecular and Cellular Biology 9, no. 9 (September 1989): 4032–37. http://dx.doi.org/10.1128/mcb.9.9.4032.

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We have cloned the polyomavirus mutant fPyF9, which persists in an episomal state in F9 embryonal carcinoma cells (K. Ariizumi and H. Ariga, Mol. Cell. Biol. 6:3920-3927, 1986). fPyF9 carries three copies of exogenous sequences, the prototype of which is a 21-base-pair repeat (box DNA), in the region of the enhancer B domain of wild-type polyomavirus DNA. The consensus sequence, GCATTCCATTGTT, is 13 base pairs long. The box DNA inserted into fPyF9 appeared to come from a cellular sequence and was present in many kinds of DNAs, including F9 chromosomal DNA. The biological function of box DNA was analyzed by chloramphenicol acetyltransferase expression assays, using chimeric plasmids containing box DNA conjugated with simian virus 40 promoter elements. The results showed that box DNA repressed the activities both of the simian virus 40 promoter and enhancer only in transfected undifferentiated F9 cells and not in differentiated LTK- cells. Box DNA functioned independently of orientation and position with respect to the promoter in an enhancerlike manner, although the effect of box DNA was opposite that of the enhancer. The XhoI linker insertion into the consensus sequences of box DNA abolished the repression activity, and the protein(s) recognizing the consensus sequences was identified only in F9 cells, not in L cells. These analyses suggest that box DNA may be a negative regulatory element that functions in undifferentiated cells.
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26

Ariizumi, K., H. Takahashi, M. Nakamura, and H. Ariga. "Negative transcriptional regulatory element that functions in embryonal carcinoma cells." Molecular and Cellular Biology 9, no. 9 (September 1989): 4032–37. http://dx.doi.org/10.1128/mcb.9.9.4032-4037.1989.

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We have cloned the polyomavirus mutant fPyF9, which persists in an episomal state in F9 embryonal carcinoma cells (K. Ariizumi and H. Ariga, Mol. Cell. Biol. 6:3920-3927, 1986). fPyF9 carries three copies of exogenous sequences, the prototype of which is a 21-base-pair repeat (box DNA), in the region of the enhancer B domain of wild-type polyomavirus DNA. The consensus sequence, GCATTCCATTGTT, is 13 base pairs long. The box DNA inserted into fPyF9 appeared to come from a cellular sequence and was present in many kinds of DNAs, including F9 chromosomal DNA. The biological function of box DNA was analyzed by chloramphenicol acetyltransferase expression assays, using chimeric plasmids containing box DNA conjugated with simian virus 40 promoter elements. The results showed that box DNA repressed the activities both of the simian virus 40 promoter and enhancer only in transfected undifferentiated F9 cells and not in differentiated LTK- cells. Box DNA functioned independently of orientation and position with respect to the promoter in an enhancerlike manner, although the effect of box DNA was opposite that of the enhancer. The XhoI linker insertion into the consensus sequences of box DNA abolished the repression activity, and the protein(s) recognizing the consensus sequences was identified only in F9 cells, not in L cells. These analyses suggest that box DNA may be a negative regulatory element that functions in undifferentiated cells.
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27

Wagner, Elias, John M. Kane, Christoph U. Correll, Oliver Howes, Dan Siskind, William G. Honer, Jimmy Lee, Peter Falkai, Thomas Schneider-Axmann, and Alkomiet Hasan. "Clozapine Combination and Augmentation Strategies in Patients With Schizophrenia —Recommendations From an International Expert Survey Among the Treatment Response and Resistance in Psychosis (TRRIP) Working Group." Schizophrenia Bulletin 46, no. 6 (May 18, 2020): 1459–70. http://dx.doi.org/10.1093/schbul/sbaa060.

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Abstract Background Evidence for the management of inadequate clinical response to clozapine in treatment-resistant schizophrenia is sparse. Accordingly, an international initiative was undertaken with the aim of developing consensus recommendations for treatment strategies for clozapine-refractory patients with schizophrenia. Methods We conducted an online survey among members of the Treatment Response and Resistance in Psychosis (TRRIP) working group. An agreement threshold of ≥75% (responses “agree” + “strongly agree”) was set to define a first-round consensus. Questions achieving agreement or disagreement proportions of >50% in the first round, were re-presented to develop second-round final consensus recommendations. Results Forty-four (first round) and 49 (second round) of 63 TRRIP members participated. Expert recommendations at ≥75% agreement included raising clozapine plasma levels to ≥350 ng/ml for refractory positive, negative, and mixed symptoms. Where plasma level-guided dose escalation was ineffective for persistent positive symptoms, waiting for a delayed response was recommended. For clozapine-refractory positive symptoms, combination with a second antipsychotic (amisulpride and oral aripiprazole) and augmentation with ECT achieved consensus. For negative symptoms, waiting for a delayed response was recommended, and as an intervention for clozapine-refractory negative symptoms, clozapine augmentation with an antidepressant reached consensus. For clozapine-refractory suicidality, augmentation with antidepressants or mood-stabilizers, and ECT met consensus criteria. For clozapine-refractory aggression, augmentation with a mood-stabilizer or antipsychotic medication achieved consensus. Generally, cognitive-behavioral therapy and psychosocial interventions reached consensus. Conclusions Given the limited evidence from randomized trials of treatment strategies for clozapine-resistant schizophrenia (CRS), this consensus-based series of recommendations provides a framework for decision making to manage this challenging clinical situation.
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Bhattacharyya, G. S., M. Walia, M. Nandi, A. Murli, S. Salim, S. Rajpurohit, S. Shinde, S. Aggarwal, and P. M. Parikh. "Practical consensus recommendations for neo-adjuvant chemotherapy in triple negative breast cancer." South Asian Journal of Cancer 07, no. 02 (April 2018): 156–58. http://dx.doi.org/10.4103/sajc.sajc_126_18.

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29

Petreski, Marjan, Blagica Petreski, Despina Tumanoska, Edlira Narazani, Fatush Kazazi, Galjina Ognjanov, Irena Jankovic, Arben Mustafa, and Tereza Kochovska. "The Size and Effects of Emigration and Remittances in the Western Balkans. A Forecasting Based on a Delphi Process." Südosteuropa 65, no. 4 (January 26, 2018): 679–95. http://dx.doi.org/10.1515/soeu-2017-0044.

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Abstract This paper aims at forecasting the size and effects of remittances and emigration in Macedonia, Albania, Serbia, and Kosovo, using a qualitative forecasting method, a Delphi questionnaire. The authors examined consensus building within and between two groups of respondents: ten experts and twenty remittance receivers per country, in three subsequent rounds–two on the same group and a third cross-round. Consensual results suggest that remittances in the projected five-year period will increase in Macedonia and Serbia, and will reduce in Albania and Kosovo. With less consensus, the results forecast that emigration will decelerate, except in Serbia. Emigration effects for the society have been forecast as predominantly negative due to skilled labour emigration, while remittances were forecast to maintain their effect on poverty in Macedonia and Serbia, and weaken in Albania. Consensus has been reached, except in Macedonia, that remittances will support labour market activity.
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Skeik, Ola, and Alexander Lanzon. "Robust output consensus of homogeneous multi-agent systems with negative imaginary dynamics." Automatica 113 (March 2020): 108799. http://dx.doi.org/10.1016/j.automatica.2019.108799.

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31

Zhou, Yanling, Guannan Li, Dan Li, Hongmei Cui, and Yuping Ning. "Dose reduction of risperidone and olanzapine can improve cognitive function and negative symptoms in stable schizophrenic patients: A single-blinded, 52-week, randomized controlled study." Journal of Psychopharmacology 32, no. 5 (March 1, 2018): 524–32. http://dx.doi.org/10.1177/0269881118756062.

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Background: The long-term effects of dose reduction of atypical antipsychotics on cognitive function and symptomatology in stable patients with schizophrenia remain unclear. We sought to determine the change in cognitive function and symptomatology after reducing risperidone or olanzapine dosage in stable schizophrenic patients. Methods: Seventy-five stabilized schizophrenic patients prescribed risperidone (≥4 mg/day) or olanzapine (≥10 mg/day) were randomly divided into a dose-reduction group ( n=37) and a maintenance group ( n=38). For the dose-reduction group, the dose of antipsychotics was reduced by 50%; for the maintenance group, the dose remained unchanged throughout the whole study. The Positive and Negative Syndrome Scale, Negative Symptom Assessment-16, Rating Scale for Extrapyramidal Side Effects, and Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery were measured at baseline, 12, 28, and 52 weeks. Linear mixed models were performed to compare the Positive and Negative Syndrome Scale, Negative Symptom Assessment-16, Rating Scale for Extrapyramidal Side Effects and MATRICS Consensus Cognitive Battery scores between groups. Results: The linear mixed model showed significant time by group interactions on the Positive and Negative Syndrome Scale negative symptoms, Negative Symptom Assessment-16, Rating Scale for Extrapyramidal Side Effects, speed of processing, attention/vigilance, working memory and total score of MATRICS Consensus Cognitive Battery (all p<0.05). Post hoc analyses showed significant improvement in Positive and Negative Syndrome Scale negative subscale, Negative Symptom Assessment-16, Rating Scale for Extrapyramidal Side Effects, speed of processing, working memory and total score of MATRICS Consensus Cognitive Battery for the dose reduction group compared with those for the maintenance group (all p<0.05). Conclusions: This study indicated that a risperidone or olanzapine dose reduction of 50% may not lead to more severe symptomatology but can improve speed of processing, working memory and negative symptoms in patients with stabilized schizophrenia.
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32

Bloomfield, Robert, and Jeffrey Hales. "An Experimental Investigation of the Positive and Negative Effects of Mutual Observation." Accounting Review 84, no. 2 (March 1, 2009): 331–54. http://dx.doi.org/10.2308/accr.2009.84.2.331.

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ABSTRACT: We use two experiments to test predictions about the positive and negative impacts of allowing analysts to revise their forecasts in light of the consensus forecasts. We find that such mutual observation not only facilitates information aggregation, but also induces free riding, which offsets the benefits of information aggregation unless incentives for accuracy are high. In our second experiment, we find that participants acting as investors anticipate these effects in the consensus and adjust their own forecasts accordingly. Our study demonstrates that the positive and negative effects of mutual observation are more complex than typically portrayed in the debate about analyst independence, and provides a framework that can be used in future research on the interactive nature of public forecasting.
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33

Studenikin, Vladimir M., K. A. Kazakova, Yu S. Akoev, and A. V. Migali. "RICKETS, VITAMIN D DEFICIENCY, AND GLOBAL CONSENSUS RECOMMENDATIONS ON PREVENTION AND MANAGEMENT OF NUTRITIONAL RICKETS: RUSSIAN PEDIATRICIANS’ OPINION." Russian Pediatric Journal 20, no. 2 (April 30, 2019): 116–22. http://dx.doi.org/10.18821/1560-9561-2017-20-2-116-122.

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The article focuses on Global Consensus recommendations on prevention and management of nutritional rickets (2016), created by 33 foreign experts, representing 11 pediatric communities from 18 countries. Positive and negative aspects of these Consensus recommendations are reviewed and carped when necessary. The need for the development of Russian national consensus on rickets prevention and management is noted.
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34

Pretsch, Johanna, Nina Heckmann, Barbara Flunger, and Manfred Schmitt. "Agree or Disagree?" European Journal of Psychological Assessment 30, no. 1 (May 1, 2014): 31–39. http://dx.doi.org/10.1027/1015-5759/a000165.

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Consensus obtained in personality judgments based on thin slices of behavior was examined by manipulating the shared meaning of the traits being judged, the accountability for the judgments, and the amount of target information. 160 judges rated a total of 60 teachers on the Big Five personality dimensions. Consensus was approached from a judge and from a target perspective. A shared meaning had a negative effect on consensus in Extraversion ratings. Accountability had a consistently negative effect across consensus perspectives. A positive effect for amount of target information was found for Neuroticism. Additionally, it was shown that, under different conditions, judgments were based more or less on shared stereotypes. Results suggest that the degree to which we agree on our judgments of others can easily be manipulated by external influences, thus involving significant practical implication for various contexts.
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35

Bilanchone, V. W., J. A. Claypool, P. T. Kinsey, and S. B. Sandmeyer. "Positive and negative regulatory elements control expression of the yeast retrotransposon Ty3." Genetics 134, no. 3 (July 1, 1993): 685–700. http://dx.doi.org/10.1093/genetics/134.3.685.

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Abstract We report the results of an analysis of Ty3 transcription and identification of Ty3 regions that mediate pheromone and mating-type regulation to coordinate its expression with the yeast life cycle. A set of strains was constructed which was isogenic except for the number of Ty3 elements, which varied from zero to three. Analysis of Ty3 expression in these strains showed that each of the three elements was transcribed and that each element was regulated. Dissection of the long terminal repeat regulatory region by Northern blot analysis of deletion mutants and reporter gene analysis showed that the upstream junction of Ty3 with flanking chromosomal sequences contained a negative control region. A 19-bp fragment (positions 56-74) containing one consensus copy and one 7 of 8-bp match to the pheromone response element (PRE) consensus was sufficient to mediate pheromone induction in either haploid cell type. Deletion of this region, however, did not abolish expression, indicating that other sequences also activate transcription. A 24-bp block immediately downstream of the PRE region contained a sequence similar to the a1-alpha 2 consensus that conferred mating-type control. A single base pair mutation in the region separating the PRE and a1-alpha 2 sequences blocked pheromone induction, but not mating-type control. Thus, the long terminal repeat of Ty3 is a compact, highly regulated, mobile promoter which is responsive to cell type and mating.
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36

Hébert-Croteau, Nicole, Jacques Brisson, Jean Latreille, Gilles Gariépy, Caty Blanchette, and Luc Deschênes. "Time Trends in Systemic Adjuvant Treatment for Node-Negative Breast Cancer." Journal of Clinical Oncology 17, no. 5 (May 1999): 1458. http://dx.doi.org/10.1200/jco.1999.17.5.1458.

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PURPOSE: We conducted a population-based study in Quebec, Canada, to assess longitudinal changes in systemic adjuvant therapy for node-negative breast cancer. MATERIALS AND METHODS: A stratified random sample was selected among women with newly diagnosed node-negative breast cancer in 1988, 1991, and 1993. Information on the patient, her tumor, source of care, and treatment was abstracted from medical charts. Patients were classified as being at minimal, moderate, or high risk of recurrence on the basis of criteria proposed at the 4th International Conference on Adjuvant Therapy of Primary Breast Cancer (St. Gallen, Switzerland, 1992), and systemic adjuvant treatment received was dichotomized as being consistent or not consistent with consensus recommendations. RESULTS: Overall, 1,578 cases of invasive breast carcinoma were reviewed. The proportion of patients who were given hormonal or cytotoxic treatment increased from 51.7% to 73.1% from 1988 to 1993. Virtually all women at minimal risk were treated in 1991 and 1993 according to the consensus statement. The proportions of women so treated were 75.0% and 65.4% in the moderate- and high-risk categories, respectively, in 1991. In 1993, these proportions were 71.4% and 67.0%, respectively. Omission of chemotherapy, especially in high-risk women with estrogen receptor–negative tumors who were 50 to 69 years of age, was the most frequent inconsistency with guidelines. CONCLUSION: Systemic adjuvant therapy for node-negative breast cancer has gained acceptance. Better understanding of the decision-making process, of the perception of the risks and benefits involved, and of the impact of alternative strategies for the dissemination of consensus recommendations are needed to promote the use of chemotherapy in specific categories of women who are at high risk of recurrence.
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37

Gustafson, Abel, and Ronald E. Rice. "A review of the effects of uncertainty in public science communication." Public Understanding of Science 29, no. 6 (July 17, 2020): 614–33. http://dx.doi.org/10.1177/0963662520942122.

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Uncertainty is inherent to science and science communication. However, the evidence appears mixed regarding whether portraying uncertainty in science communication has positive or negative effects. We review a diverse range of experimental literature ( k = 48; from 40 searches and 8000 retrievals), summarize the extant findings, and observe how the effects vary across four different types of communicated uncertainty ( deficient, technical, scientific, and consensus uncertainty). The results indicate that most findings of negative effects (such as reduced credibility and beliefs) are from experiments that operationalized uncertainty as disagreement or conflict in science ( consensus uncertainty). In this review, consensus uncertainty was never found to have positive effects. In contrast, uncertainty in the form of quantified error ranges and probabilities ( technical uncertainty) in these studies has had only positive or null effects, not negative effects. We also highlight frequent moderators of the effects of uncertainty, such as prior beliefs and worldviews.
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38

Herold, Manfred, Werner Klotz, Luis E. C. Andrade, Karsten Conrad, Wilson de Melo Cruvinel, Jan Damoiseaux, Marvin J. Fritzler, Carlos A. von Muhlen, Minoru Satoh, and Edward K. L. Chan. "International Consensus on Antinuclear Antibody Patterns: defining negative results and reporting unidentified patterns." Clinical Chemistry and Laboratory Medicine (CCLM) 56, no. 10 (September 25, 2018): 1799–802. http://dx.doi.org/10.1515/cclm-2018-0052.

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39

Hu, Ai-Hua, Man-Feng Hu, Liu-Xiao Guo, and Jin-De Cao. "Consensus of a leader-following multi-agent system with negative weights and noises." IET Control Theory & Applications 8, no. 2 (January 16, 2014): 114–19. http://dx.doi.org/10.1049/iet-cta.2013.0216.

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40

Su, Housheng, Yaping Sun, and Zhigang Zeng. "Semiglobal Observer-Based Non-Negative Edge Consensus of Networked Systems With Actuator Saturation." IEEE Transactions on Cybernetics 50, no. 6 (June 2020): 2827–36. http://dx.doi.org/10.1109/tcyb.2019.2917006.

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41

Montgomery, S. A., and B. van Zwieten-Boot. "ECNP consensus meeting. Negative, depressive and cognitive symptoms of schizophrenia. Nice, March 2004." European Neuropsychopharmacology 17, no. 1 (January 2007): 70–77. http://dx.doi.org/10.1016/j.euroneuro.2006.05.004.

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42

Wagner, Elias, John Kane, Christoph Correll, Oliver Howes, Dan Siskind, William G. Honer, Jimmy Lee, Peter Falkai, Thomas Schneider-Axmann, and Alkomiet Hasan. "T204. CLOZAPINE COMBINATION AND AUGMENTATION STRATEGIES IN PATIENTS WITH SCHIZOPHRENIA –RECOMMENDATIONS FROM AN INTERNATIONAL EXPERT SURVEY AMONG THE TREATMENT RESPONSE AND RESISTANCE IN PSYCHOSIS (TRRIP) WORKING GROUP." Schizophrenia Bulletin 46, Supplement_1 (April 2020): S309—S310. http://dx.doi.org/10.1093/schbul/sbaa029.764.

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Abstract Background Evidence for the management of inadequate clinical response to clozapine in treatment-resistant schizophrenia is sparse. Accordingly, an international initiative aimed to develop consensus recommendations for treatment strategies for clozapine-refractory patients with schizophrenia. Methods We conducted an online survey among members of the Treatment Response and Resistance in Psychosis (TRRIP) working group. An agreement threshold of ≥75% (responses “agree”+“strongly agree”) was set to define a first-round consensus. Questions achieving agreement or disagreement proportions of &gt;50% in the first round, were re-presented to develop second-round final consensus recommendations. Results From a total of 61 TRRIP members 44 (first round) and 49 (second round) participated in the consensus-process. Expert recommendations included raising clozapine plasma levels to ≥350 ng/mL for refractory positive, negative and mixed symptoms. In case of ineffective plasma level-guided dose escalation waiting for a delayed response was recommended for persistent positive symptoms. For ongoing clozapine-refractory positive symptoms, combination with a second antipsychotic, (amisulpride and oral aripiprazole) and augmentation with ECT achieved consensus. For clozapine-refractory negative symptoms, waiting for a delayed response was recommended, and as an intervention, clozapine augmentation with an antidepressant reached consensus. For clozapine-refractory suicidality, augmentation with antidepressants or mood-stabilisers, and ECT met consensus criteria. For aggression, augmentation with a mood-stabiliser or combination with antipsychotic medication achieved consensus. Generally, cognitive-behavioural therapy (CBT) and psychosocial interventions reached consensus. Discussion This consensus-based series of recommendations provides a framework for decision-making to manage the challenging clinical situation of CRS, where the evidence from randomised-controlled trials remains sparse.
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43

Zandvoort, H. "Globalisation, environmental harm, and progress:the role of consensus and liability." Water Science and Technology 52, no. 6 (September 1, 2005): 43–50. http://dx.doi.org/10.2166/wst.2005.0149.

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Two conditions are stated that must be fulfilled to make sure that the negative effects of environmental pollution and risks stemming from the spread of free markets and technology do not outweigh the beneficial effects of this development. (1) For all activities, all those who may experience the negative effects of the activities must have given their consent to the activities and the conditions under which they are performed. (2) Those who engage in activities without this consent must be held to unlimited and unconditional liability for the negative effects that the activities may cause for those who did not give their consent. These conditions are necessary principles for the responsible management of environmental harm and risks. If the conditions are not satisfied, then the belief that the global spread of free markets and technology is beneficial for all, or does not harm anyone, cannot be justified. Neither of the conditions is fulfilled at present. This is illustrated using examples drawn from international legislation regarding liability for oil transportation, energy production, genetically modified organisms and chemicals in the environment. Directions for improving existing liability legislation are identified. The relationship between the conditions and the precautionary principle is explained.
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44

Dance, David A. B., Michael Knappik, Sabine Dittrich, Viengmon Davong, Joy Silisouk, Manivanh Vongsouvath, Sayaphet Rattanavong, et al. "Evaluation of consensus method for the culture of Burkholderia pseudomallei in soil samples from Laos." Wellcome Open Research 3 (October 15, 2018): 132. http://dx.doi.org/10.12688/wellcomeopenres.14851.1.

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Background: We have previously shown that PCR following enrichment culture is the most sensitive method to detect Burkholderia pseudomallei in environmental samples. Here we report an evaluation of the published consensus method for the culture of B. pseudomallei from Lao soil in comparison with our conventional culture method and with PCR with or without prior broth enrichment. Methods: One hundred soil samples were collected from a field known to contain B. pseudomallei and processed by: (i) the conventional method, (ii-iii) the consensus method using media prepared in either Laos or Thailand, and (iv) the consensus method performed in Thailand, as well as by (v) PCR following direct extraction of DNA from soil and (vi) PCR following broth pre-enrichment. Results: The numbers of samples in which B. pseudomallei was detected were 42, 10, 7, 6, 6 and 84, respectively. However, two samples were positive by the consensus method but negative by conventional culture, and one sample was negative by PCR following enrichment although B. pseudomallei was isolated by the conventional culture method. Conclusions/Discussion: The results show that no single method will detect all environmental samples that contain B. pseudomallei. People conducting environmental surveys for this organism should be aware of the possibility of false-negative results using the consensus culture method. An approach that entails screening using PCR after enrichment, followed by the evaluation of a range of different culture methods on PCR-positive samples to determine which works best in each setting, is recommended.
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Dance, David A. B., Michael Knappik, Sabine Dittrich, Viengmon Davong, Joy Silisouk, Manivanh Vongsouvath, Sayaphet Rattanavong, et al. "Evaluation of consensus method for the culture of Burkholderia pseudomallei in soil samples from Laos." Wellcome Open Research 3 (November 21, 2018): 132. http://dx.doi.org/10.12688/wellcomeopenres.14851.2.

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Background: We have previously shown that PCR following enrichment culture is the most sensitive method to detect Burkholderia pseudomallei in environmental samples. Here we report an evaluation of the published consensus method for the culture of B. pseudomallei from Lao soil in comparison with our conventional culture method and with PCR with or without prior broth enrichment. Methods: One hundred soil samples were collected from a field known to contain B. pseudomallei and processed by: (i) the conventional method, (ii-iii) the consensus method using media prepared in either Laos or Thailand, and (iv) the consensus method performed in Thailand, as well as by (v) PCR following direct extraction of DNA from soil and (vi) PCR following broth pre-enrichment. Results: The numbers of samples in which B. pseudomallei was detected were 42, 10, 7, 6, 6 and 84, respectively. However, two samples were positive by the consensus method but negative by conventional culture, and one sample was negative by PCR following enrichment although B. pseudomallei was isolated by the conventional culture method. Conclusions/Discussion: The results show that no single method will detect all environmental samples that contain B. pseudomallei. People conducting environmental surveys for this organism should be aware of the possibility of false-negative results using the consensus culture method. An approach that entails screening using PCR after enrichment, followed by the evaluation of a range of different culture methods on PCR-positive samples to determine which works best in each setting, is recommended.
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46

Leslie, Alasdair, Daniel Kavanagh, Isobella Honeyborne, Katja Pfafferott, Charles Edwards, Tilly Pillay, Louise Hilton, et al. "Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA." Journal of Experimental Medicine 201, no. 6 (March 21, 2005): 891–902. http://dx.doi.org/10.1084/jem.20041455.

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Human immunodeficiency virus (HIV)-1 amino acid sequence polymorphisms associated with expression of specific human histocompatibility leukocyte antigen (HLA) class I alleles suggest sites of cytotoxic T lymphocyte (CTL)-mediated selection pressure and immune escape. The associations most frequently observed are between expression of an HLA class I molecule and variation from the consensus sequence. However, a substantial number of sites have been identified in which particular HLA class I allele expression is associated with preservation of the consensus sequence. The mechanism behind this is so far unexplained. The current studies, focusing on two examples of “negatively associated” or apparently preserved epitopes, suggest an explanation for this phenomenon: negative associations can arise as a result of positive selection of an escape mutation, which is stable on transmission and therefore accumulates in the population to the point at which it defines the consensus sequence. Such negative associations may only be in evidence transiently, because the statistical power to detect them diminishes as the mutations accumulate. If an escape variant reaches fixation in the population, the epitope will be lost as a potential target to the immune system. These data help to explain how HIV is evolving at a population level. Understanding the direction of HIV evolution has important implications for vaccine development.
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47

Korenaga, Risa, Joji Ando, Keisuke Kosaki, Masashi Isshiki, Yoshio Takada, and Akira Kamiya. "Negative transcriptional regulation of the VCAM-1 gene by fluid shear stress in murine endothelial cells." American Journal of Physiology-Cell Physiology 273, no. 5 (November 1, 1997): C1506—C1515. http://dx.doi.org/10.1152/ajpcell.1997.273.5.c1506.

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To explore the mechanism of shear stress-induced downregulation of vascular cell adhesion molecule 1 (VCAM-1) expression in murine endothelial cells (ECs), we examined the effect of shear stress on VCAM-1 gene transcription and assessed the cis-acting elements involved in this phenomenon. VCAM-1 mRNA expression was downregulated at the transcriptional level as defined by nuclear run-on assay and transient transfection of VCAM-1 promoter-luciferase gene constructs. The luciferase assay on the VCAM-1 deletion mutants revealed that the cis-acting element is contained between −694 and −329 bp upstream from the transcription initiation site. Gel shift assay using overlapping oligonucleotide probes of this region showed that oligonucleotides containing a double AP-1 consensus sequence (TGACTCA) formed distinct complexes with nuclear proteins extracted from shear-stressed cells. Mutation of either one or both of two AP-1 consensus sequences completely abolished the ability of the promoter to respond to shear stress. These results suggest that fluid shear stress downregulates the transcription of the VCAM-1 gene via an upstream cis-element, a double AP-1 consensus sequence, in murine lymph node venule ECs.
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48

Leenhardt, Romain, Cynthia Li, Anastasios Koulaouzidis, Flaminia Cavallaro, Franck Cholet, Rami Eliakim, Ignacio Fernandez-Urien, et al. "Nomenclature and semantic description of vascular lesions in small bowel capsule endoscopy: an international Delphi consensus statement." Endoscopy International Open 07, no. 03 (February 28, 2019): E372—E379. http://dx.doi.org/10.1055/a-0761-9742.

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Abstract Background and study aims Nomenclature and descriptions of small bowel (SB) vascular lesions in capsule endoscopy (CE) are scarce in the medical literature. They are mostly based on the reader's opinion and thus differ between experts, with a potential negative impact on clinical care, teaching and research regarding SBCE. Our aim was to better define a nomenclature and to give a description of the most frequent vascular lesions in SBCE. Methods A panel of 18 European expert SBCE readers was formed during the UEGW 2016 meeting. Three experts constructed an Internet-based four-round Delphi consensus, but did not participate in the voting process. They built questionnaires that included various still frames of vascular lesions obtained with a third-generation SBCE system. The 15 remaining participants were asked to rate different proposals and description of the most common SB vascular lesions. A 6-point rating scale (varying from ‘strongly disagree’ to ‘strongly agree’) was used successive rounds. The consensus was reached when at least 80 % voting members scored the statement within the ‘agree’ or ‘strongly agree’. Results Consensual terms and descriptions were reached for angiectasia/angiodysplasia, erythematous patch, red spot/dot, and phlebectasia. A consensual description was reached for more subtle vascular lesions tentatively named “diminutive angiectasia” but no consensus was reached for this term. Conclusion An international group has reached a consensus on the nomenclature and descriptions of the most frequent and relevant SB vascular lesions in CE. These terms and descriptions are useful in daily practice, for teaching and for medical research purposes.
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Wang, Peng, Hui Ai, Jie Huo, Feng-Chun Pan, and Xu-Ming Wang. "How can we reach consensus? The answer from the micro-configurations of a 2-D Ising model." International Journal of Modern Physics C 31, no. 07 (July 2020): 2050098. http://dx.doi.org/10.1142/s0129183120500989.

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We study opinion formation by uncovering the relevant aspects hiding in the distribution of micro-configurations in a 2-D Ising model. The external field denotes the external influence such as guiding viewpoint, and temperature represents randomness of the agents. The full-positive configuration or the full-negative configuration means consensus. We find that the probability of the full-positive configuration and the full-negative configuration can reach [Formula: see text] (which implies the equal splitting of a group) if the interaction is strong enough and the system is free from external field; the probability of the full-positive configuration can reach 1 (which means consensus) if the positive external field is strong enough under condition of given interaction and temperature. These phenomena are regarded as the reversing mechanism of the full-negative configuration induced by the external field — an opinion reversal. The equal splitting and consensus can be broken down as temperature rises. We discuss the dependence of interaction strength [Formula: see text] (with which the equal splitting occurs) on temperature [Formula: see text], the dependence of external field strength [Formula: see text] (with which the consensus occurs) on interaction strength [Formula: see text] at a certain temperature, as well as the scaling relations responsible for the probability of the full-negative configuration varying with temperature under different conditions. The findings provide us with a good description to understand opinion formation.
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50

Iqbal, Fahad M., Jeremy P. Reid, and Raghavan Vidya. "Oncoplastic breast surgery: the role of negative pressure wound therapy." Journal of Wound Care 29, no. 12 (December 2, 2020): 777–80. http://dx.doi.org/10.12968/jowc.2020.29.12.777.

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Wound-related problems following breast surgery are common. Delayed wound healing can lead to poor cosmesis and, among breast cancer patients, can result in delays in receiving adjuvant treatment. The aim of our review was to look at the literature in relation to the role of negative pressure wound therapy in oncoplastic breast surgery, as at the time of writing, there is no consensus on the use of prophylactic negative pressure dressings in closed wounds following breast surgery.
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