Relevant bibliographies by topics / Negative Elongation Factor complex

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Negative Elongation Factor complex'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Negative Elongation Factor complex"

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Huang, Mengling, Abrar Ahmed, Wei Wang, et al. "Negative Elongation Factor (NELF) Inhibits Premature Granulocytic Development in Zebrafish." International Journal of Molecular Sciences 23, no. 7 (2022): 3833. http://dx.doi.org/10.3390/ijms23073833.

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Gene expression is tightly regulated during hematopoiesis. Recent studies have suggested that RNA polymerase II (Pol II) promoter proximal pausing, a temporary stalling downstream of the promoter region after initiation, plays a critical role in regulating the expression of various genes in metazoans. However, the function of proximal pausing in hematopoietic gene regulation remains largely unknown. The negative elongation factor (NELF) complex is a key factor important for this proximal pausing. Previous studies have suggested that NELF regulates granulocytic differentiation in vitro, but its
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Yamaguchi, Yuki, Naoto Inukai, Takashi Narita, Tadashi Wada, and Hiroshi Handa. "Evidence that Negative Elongation Factor Represses Transcription Elongation through Binding to a DRB Sensitivity-Inducing Factor/RNA Polymerase II Complex and RNA." Molecular and Cellular Biology 22, no. 9 (2002): 2918–27. http://dx.doi.org/10.1128/mcb.22.9.2918-2927.2002.

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ABSTRACT Negative elongation factor (NELF) is a human transcription factor complex that cooperates with DRB sensitivity-inducing factor (DSIF)/hSpt4-hSpt5 to repress elongation by RNA polymerase II (RNAPII). NELF activity is associated with five polypeptides, including NELF-A, a candidate gene product for Wolf-Hirschhorn syndrome, and NELF-E, a putative RNA-binding protein with arginine-aspartic acid (RD) dipeptide repeats. Here we report several important findings regarding the DSIF/NELF-dependent elongation control. First, we have established an effective method for purifying the active NELF
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Missra, A., and D. S. Gilmour. "Interactions between DSIF (DRB sensitivity inducing factor), NELF (negative elongation factor), and the Drosophila RNA polymerase II transcription elongation complex." Proceedings of the National Academy of Sciences 107, no. 25 (2010): 11301–6. http://dx.doi.org/10.1073/pnas.1000681107.

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Yu, Li, Bin Zhang, Dinesh Deochand, et al. "Negative elongation factor complex enables macrophage inflammatory responses by controlling anti-inflammatory gene expression." Journal of Immunology 204, no. 1_Supplement (2020): 152.28. http://dx.doi.org/10.4049/jimmunol.204.supp.152.28.

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Abstract Studies on macrophage gene expression have historically focused on events leading to RNA polymerase II recruitment and transcription initiation whereas the contribution of post-initiation steps to macrophage activation remains poorly understood. Here, we report widespread promoter-proximal RNA polymerase II pausing in resting macrophages, marked by broad co-localization of the negative elongation factor (NELF) complex and facilitated by PU.1. Upon inflammatory stimulation, over 60% of activated transcriptome is regulated by polymerase pause-release and a transient genome-wide NELF dis
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Ruiz, Brittany Natalie, Alvaro Lucci, Anna Barry, Kai Zhang, and Hien Dang. "Abstract 1492: Interaction between Argonaute-2 and Negative Elongation Factor-E in hepatocellular carcinoma." Cancer Research 83, no. 7_Supplement (2023): 1492. http://dx.doi.org/10.1158/1538-7445.am2023-1492.

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Abstract Hepatocellular carcinoma (HCC) continues to be one of the leading cause of cancer-related deaths globally, whose incidence is on the rise in the United States. We and others have shown that high levels of AGO2 is associated with a worse prognosis in HCC patients. Specifically, we showed AGO2 promotes HCC progression by modulating MYC mRNA stability in an RNAi-independent manner. In addition to its canonical role as an RNA binding protein, AGO2 has been demonstrated to regulate gene expression by affecting RNA polymerase II (Pol II) pausing through the Negative Elongation Factor (NELF)
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Jadlowsky, Julie K., Masanori Nojima, Takashi Okamoto, and Koh Fujinaga. "Dominant negative mutant cyclin T1 proteins that inhibit HIV transcription by forming a kinase inactive complex with Tat." Journal of General Virology 89, no. 11 (2008): 2783–87. http://dx.doi.org/10.1099/vir.0.2008/002857-0.

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Transcription of the human immunodeficiency virus type 1 (HIV) requires the interaction of the cyclin T1 (CycT1) subunit of a host cellular factor, the positive transcription elongation factor b (P-TEFb), with the viral Tat protein, at the transactivation response element (TAR) of nascent transcripts. Because of this virus-specific interaction, CycT1 may potentially serve as a target for the development of anti-HIV therapies. Here we report the development of a mutant CycT1 protein, containing three threonine-to-alanine substitutions in the linker region between two of the cyclin boxes, which
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Zhang, Zhiqiang, Alicia Klatt, David S. Gilmour, and Andrew J. Henderson. "Negative Elongation Factor NELF Represses Human Immunodeficiency Virus Transcription by Pausing the RNA Polymerase II Complex." Journal of Biological Chemistry 282, no. 23 (2007): 16981–88. http://dx.doi.org/10.1074/jbc.m610688200.

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Zhou, Meisheng, Keven Huang, Kyung-Jin Jung, et al. "Bromodomain Protein Brd4 Regulates Human Immunodeficiency Virus Transcription through Phosphorylation of CDK9 at Threonine 29." Journal of Virology 83, no. 2 (2008): 1036–44. http://dx.doi.org/10.1128/jvi.01316-08.

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ABSTRACT Positive transcription elongation factor b (P-TEFb), composed of cyclin-dependent kinase 9 (CDK9) and cyclin T, is a global transcription factor for eukaryotic gene expression, as well as a key factor for human immunodeficiency virus (HIV) transcription elongation. P-TEFb phosphorylates the carboxyl-terminal domain (CTD) of the large subunit of RNA polymerase II (RNAP II), facilitating the transition from nonprocessive to processive transcription elongation. Recently, the bromodomain protein Brd4 has been shown to interact with the low-molecular-weight, active P-TEFb complex and recru
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Fu, Junjiang, Ho-Geun Yoon, Jun Qin, and Jiemin Wong. "Regulation of P-TEFb Elongation Complex Activity by CDK9 Acetylation." Molecular and Cellular Biology 27, no. 13 (2007): 4641–51. http://dx.doi.org/10.1128/mcb.00857-06.

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ABSTRACT P-TEFb, comprised of CDK9 and a cyclin T subunit, is a global transcriptional elongation factor important for most RNA polymerase II (pol II) transcription. P-TEFb facilitates transcription elongation in part by phosphorylating Ser2 of the heptapeptide repeat of the carboxy-terminal domain (CTD) of the largest subunit of pol II. Previous studies have shown that P-TEFb is subjected to negative regulation by forming an inactive complex with 7SK small RNA and HEXIM1. In an effort to investigate the molecular mechanism by which corepressor N-CoR mediates transcription repression, we ident
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Abbas, Ata, Roshan Padmanabhan, Todd Romigh, and Charis Eng. "PTEN modulates gene transcription by redistributing genome-wide RNA polymerase II occupancy." Human Molecular Genetics 28, no. 17 (2019): 2826–34. http://dx.doi.org/10.1093/hmg/ddz112.

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Abstract Control of gene expression is one of the most complex yet continuous physiological processes impacting cellular homeostasis. RNA polymerase II (Pol II) transcription is tightly regulated at promoter-proximal regions by intricate dynamic processes including Pol II pausing, release into elongation and premature termination. Pol II pausing is a phenomenon where Pol II complex pauses within 30–60 nucleotides after initiating the transcription. Negative elongation factor (NELF) and DRB sensitivity inducing factor (DSIF) contribute in the establishment of Pol II pausing, and positive transc
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Dissertations / Theses on the topic "Negative Elongation Factor complex"

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Cruz-Gordillo, Peter G. "Unmasking Oncogene Addiction to the Epidermal Growth Factor Receptor in Triple Negative Breast Cancer: a Lesson in Intrinsic Resistance." eScholarship@UMMS, 2020. https://escholarship.umassmed.edu/gsbs_diss/1101.

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The rationale behind targeted molecular therapy in cancer, oncogene addiction, is that tumors rely on driver oncogenes to control their proliferation and survival. Therefore, an efficacious targeted therapy should induce a dual, detrimental response to the tumor. While there have been clinical success stories using targeted therapies, even tumors that are initially sensitive invariably develop resistance. In the case of triple negative breast cancer (TNBC), despite extensive evidence pointing to its driver oncogene status, inhibitors of the Epidermal Growth Factor Receptor (EGFR) are considere
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Kettenberger, Hubert. "Structure of the Complete RNA Polymerase II Elongation Complex and its Interaction with the Elongation Factor TFIIS." Diss., lmu, 2005. http://nbn-resolving.de/urn:nbn:de:bvb:19-39070.

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Pöllmann, David [Verfasser], and Patrick [Akademischer Betreuer] Cramer. "Structural and functional studies on the negative elongation factor / David Pöllmann. Betreuer: Patrick Cramer." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2015. http://d-nb.info/1112465774/34.

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Sun, Jianlong. "Role of negative elongation factor in regulation of gene expression and breast cancer progression a dissertation /." San Antonio : UTHSC, 2009. http://learningobjects.library.uthscsa.edu/cdm4/item_viewer.php?CISOROOT=/theses&CISOPTR=47&CISOBOX=1&REC=11.

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Jadlowsky, Julie Kendal. "Dual control of HIV transcription elongation virus-specific negative control by NELF-E is counterbalanced by positive transcription factor P-TEFb /." Cleveland, Ohio : Case Western Reserve University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1228234927.

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Chanarat, Sittinan. "The Prp19 complex is a novel transcription elongation factor required for TREX occupancy at transcribed genes." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-132497.

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Guo, Xieyang. "Regulation of transcription : structural studies of an RNA polymerase elongation complex bound to transcription factor NusA." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ071/document.

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La pause transcriptionnelle marquée par les ARN polymérases (RNAP) est un mécanisme clé pour réguler l'expression des gènes dans tous les règnes de la vie et est une condition préalable à la terminaison de la transcription. Le facteur de transcription bactérien essentiel NusA stimule à la fois la pause et la terminaison de la transcription, jouant ainsi un rôle central. Ici, je présente des reconstructions par cryo-microscopie électronique (cryo-EM) à une seule particule de NusA lié à des complexes d'élongation en présence et en absence d’ARN en épingle à cheveux dans le canal de sortie de l'A
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Jadlowsky, Julie Kendal. "Dual Control of HIV Transcription Elongation: Virus-Specific Negative Control by NELF-E is Counterbalanced by Positive Transcription Factor P-TEFb." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1228234927.

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Wong, Julian Y. "THE ROLE OF NEGATIVE ELONGATION FACTOR NELF IN THE REGULATION OF HIV TRANSCRIPTION, VIRAL LATENCY AND THE CONTROL OF CELLULAR GENE EXPRESSION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1333481631.

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[Verfasser], Sittinan Chanarat, and Patrick [Akademischer Betreuer] Cramer. "The Prp19 complex is a novel transcription elongation factor required for TREX occupancy at transcribed genes / Sittinan Chanarat. Betreuer: Patrick Cramer." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2011. http://d-nb.info/1015084141/34.

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Books on the topic "Negative Elongation Factor complex"

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Morales, Harold D. The 9/11 Factor. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190852603.003.0005.

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In contrast to self-produced media like reversion stories, chapter 4 documents and assesses journalistic representations of Latino Muslims. In a post-9/11 media context, Latino Muslims received increased attention from journalists. It argues that these news stories have, however, reductively focused on “conversion” at the expense of more complex and diverse representations. Although much of this coverage has been reductive, it has generally not been overtly negative. An exception to this pattern is Spanish language news media, which has represented Latino Muslims in negative ways that echo the
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Korkeila, Maarit, Bengt Lindholm, and Peter Stenvinkel. The obese patient (metabolic syndrome). Edited by Giuseppe Remuzzi. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0168.

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Overweight and obesity cause pathophysiological changes in renal function and increase the risk for chronic kidney disease in otherwise healthy subjects. This should not be a surprise as the risk factors for metabolic syndrome largely overlap with those for chronic kidney disease. Intentional weight loss has beneficial effects on risk factors, but long term effects are less clear. Bariatric surgery does seem to achieve rapid benefits on blood pressure and proteinuria as well as on other aspects of metabolic syndrome, but its long term implications for kidney function are less clear cut as ther
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Book chapters on the topic "Negative Elongation Factor complex"

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Semenza, Gregg L. "Trans-Acting Factors." In Transcription Factors and Huinan Disease. Oxford University PressNew York, NY, 1998. http://dx.doi.org/10.1093/oso/9780195112399.003.0003.

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Abstract Transcription factors are trans-acting proteins that affect the rate of transcription by specific interactions with DNA and/or other proteins (see Chapter 1). Transcriptional activators and repressors have positive and negative effects, respectively, on the rate of transcription. Transcriptional regulators may affect the rate of transcription initiation and/or mRNA elongation. In addition to DNA-binding activators and repressors, a variety of coactivators, corepressors, and other cofactors have been identified that do not bind to DNA directly but instead interact with the DNA-binding
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Yudkowsky, Eliezer. "Artificial Intelligence as a positive and negative factor in global risk." In Global Catastrophic Risks. Oxford University Press, 2008. http://dx.doi.org/10.1093/oso/9780198570509.003.0021.

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By far the greatest danger of Artificial Intelligence (AI) is that people conclude too early that they understand it. Of course, this problem is not limited to the field of AI. Jacques Monod wrote: ‘A curious aspect of the theory of evolution is that everybody thinks he understands it’ (Monod, 1974). The problem seems to be unusually acute in Artificial Intelligence. The field of AI has a reputation for making huge promises and then failing to deliver on them. Most observers conclude that AI is hard, as indeed it is. But the embarrassment does not stem from the difficulty. It is difficult to b
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Peck, Stephanie Knatz, Stuart B. Murray, and Walter H. Kaye. "Clinical Guidelines for the Treatment of Anxiety in Eating Disorders." In Clinical Handbook of Complex and Atypical Eating Disorders, edited by Leslie K. Anderson, Stuart B. Murray, and Walter H. Kaye. Oxford University Press, 2017. http://dx.doi.org/10.1093/med-psych/9780190630409.003.0002.

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Approximately two-thirds of individuals diagnosed with eating disorders have had one or more concurrent anxiety disorders in their lifetime. Anxiety symptoms most often predate the onset of an eating disorder and are associated with worse outcomes, implicating anxiety as a possible vulnerability factor in the onset and maintenance of an eating disorder. Individuals with eating disorders also tend to possess personality traits associated with anxiety. This significant comorbidity is likely a result of a shared underlying temperament profile that may predispose individuals to both an eating diso
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Grover, Purva. "Hide and Seek." In Legal and Ethical Issues in Emergency Medicine. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780190066420.003.0010.

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The system of mandatory reporting was created in response to a growing recognition of devastation that child abuse was causing in the United States. All states designate people in certain professions as “mandated reporters.” This has led to discussion regarding unintended consequences or negative effects of mandatory reporting. What are our obligations toward adult patients who confide that they were abused as a child but are unsure if they want to report this now? Are we still the mandated reporters? How does patient autonomy factor into this? These laws and statutes are complex, and our lega
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Zhang, Yongqin, and Kory Iman. "Using Geospatial Analysis to Assist with Clean Vehicle Infrastructure." In GIS and Spatial Analysis [Working Title]. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.110864.

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Fuel-based vehicles are a significant source of greenhouse gas emissions in America. Electric vehicles (EVs) offer a potential solution to this problem as a cleaner transportation technology. However, to promote the use of EVs, it is crucial to establish a robust infrastructure of charging stations. This research utilized a multi-factor geospatial analysis to address the complex problem of establishing an optimal EV infrastructure. Several factors, such as land use, demographics, and employment centers, were individually analyzed to determine their suitability for EV charging stations. By cons
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Feeley, Malcolm M., and Malcolm Langford. "Introduction." In The Limits of the Legal Complex. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780192848413.003.0001.

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This chapter situates the examination of Nordic lawyers in this book within the broader scholarship on lawyer’s engagement with politics and liberalism. It charts firstly the revisionist body of scholarly work in the 1970s that challenged the conventional understanding that the legal profession enjoyed the status of a “high calling”. Instead, the legal profession was overwhelming devoted to protecting and expanding its privileges and prestige. This realist conception is later moderated by some scholars who make the more modest claim that legal complexes emerge to fight for political liberalism
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Wigand, Moritz E., and Thomas Becker. "Social constructs and diagnostic perspectives." In Oxford Textbook of Social Psychiatry, edited by Dinesh Bhugra, Driss Moussaoui, and Tom J. Craig. Oxford University PressOxford, 2022. http://dx.doi.org/10.1093/med/9780198861478.003.0004.

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Abstract The aim of this chapter is to summarize different diagnostic concepts of mental illness. There are opposing (or complementary) views of mental illness ranging from neurobiological to social concepts, and psychiatry is prone to cyclical paradigm shifts, which emerge from complex social processes. To organize psychopathological data, different approaches such as dimensional concepts, categorical concepts, and the concept of ideal types have been proposed. For research purposes, there are several concepts such as the Research Domain Criteria (RDoC), the Hierarchical Taxonomy of Psychopat
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Olsnes, S. "Pseudomonas aeruginosa exotoxin A." In Guidebook to Protein Toxins and Their Use in Cell Biology. Oxford University PressOxford, 1997. http://dx.doi.org/10.1093/oso/9780198599555.003.0017.

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Abstract Pseudomonas aeruginosa exotoxin A (PEA, MW 66 kDa, 613 amino acids, sequence accession number: PSEETA K01397) consists of three major domains (Allured et al. 1986), as indicated in Fig. 1. The N-terminal domain la (amino acids 1-252) binds to the ai-macroglobulin receptor at the cell surface (Kounnas et al. 1992), domain II (amino acids 253-364) mediates translocation of itself and domain Ill to the cytosol, and the (-terminal domain Ill (amino acids 405-613) catalyses the transfer of ADP-ribose from NAD to the diphthamide residue of elongation factor 2, which is thereby inactivated (
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Batrymenko, Oleg, and Vitalii Turenko. "POLICY OF TOLERANCE AS FACTOR IN REDUCING INTELECTUAL MIGRATION IN UKRAINE." In Scientific space: integration of traditional and innovative processes. Publishing House “Baltija Publishing”, 2023. http://dx.doi.org/10.30525/978-9934-26-310-1-15.

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Study of the peculiarities of the dynamics of intellectual migration at all levels (secondary, higher school and highly qualified personnel) in independent Ukraine, as well as consideration of the importance of tolerance in migration processes and key factors in the formation and functioning of the relevant policy in our country. Methodology. The key methodological basis was the interdisciplinary approach, which made it possible to apply the work of both political scientists and state managers, as well as economists, sociologists and psychologists, in the given problem. Also, important methods
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Ellison, Nick. "The whys and wherefores of Brexit." In Social Policy Review 29. Policy Press, 2017. http://dx.doi.org/10.1332/policypress/9781447336211.003.0001.

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This introductory chapter examines the ‘whys and wherefores of Brexit’, considering not just the political roots of the referendum result but also its complex social and economic roots. The analysis suggests that although voters were largely influenced by a narrow range of core issues — notably the impact of rising net migration, anxieties about sovereignty and fears about the trajectory of the UK economy — these concerns may in turn have been provoked by two factors. First, labour markets became increasingly ‘flexible’ and less secure as a result of globalisation, and, second, this insecurity
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Conference papers on the topic "Negative Elongation Factor complex"

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Evertz, T., and V. Flaxa. "Improved Test Method for Analysis of SOHIC- and NNSCC Susceptibility to Cracking by Cyclic Loading." In CORROSION 2003. NACE International, 2003. https://doi.org/10.5006/c2003-03525.

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Abstract Susceptibility of steel pipes to cracking in subsequently contact with solutions -either wet sour gas or near neutral solutions- is a dominant factor for residual life of gas-linepipes. Three different cracking phenomens are cause of a major concern for applications in wet H2S environments, namely Hydrogen Induced Cracking (HIC), Sulfide Stress Cracking (SSC) and Stress Orientated Hydrogen Induced Cracking (SOHIC). Whereas laboratory test methods for HIC without mechanical loading are established for pipeline steels the situation is different in cases with external stress or additiona
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Баранов, Д. Ю., С. В. Долгов, and В. Р. Тимербаев. "KNOCKOUT OF TOMATO TRANSLATION ELONGATION FACTOR GENES USING CRISPR-CAS9 TECHNOLOGY." In Биотехнология в растениеводстве, животноводстве и сельскохозяйственной микробиологии. Crossref, 2022. http://dx.doi.org/10.48397/arriab.2022.22.xxii.094.

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Фитопатогенные вирусы наносят значительный вред сельскохозяйственному производству. Несмотря на развитие технологий по сдерживанию вирусных болезней томата, включающих как методы классической селекции, так и биотехнологические методы, данные заболевания вызывают серьезные потери урожая по всему миру. Самовоспроизведение фитовирусов включает взаимодействие между вирусными компонентами и факторами растения-хозяина, поэтому мутации в соответствующих генах последних могут обеспечить резистентность к вирусной инфекции. В настоящее время, имеются данные, что белки комплекса эукариотического фактора
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Molkaraie, Mehdi, and Hans-Andrea Loeliger. "Extending monte carlo methods to factor graphs with negative and complex factors." In 2012 IEEE Information Theory Workshop (ITW 2012). IEEE, 2012. http://dx.doi.org/10.1109/itw.2012.6404694.

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Kabil, Nashwa N., Recep Bayraktar, Nermin Kahraman, and Bulent Ozpolat. "Abstract 3249: Thymoquinone inhibits elongation factor 2 kinase signaling axis by inducing tumor suppressor miR-603 in triple negative breast cancer cells." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-3249.

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Mokhlis, Hamada Ahmed, Nermin Kahraman, Seyda Baydogan, et al. "Abstract 4262: MiR-873 is the master regulator of autophagy genes through a novel negative feedback mechanism mediated by Elongation factor 2 kinase (eEF-2K) and suppresses tumor growth and progression of triple negative breast cancer." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-4262.

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Mokhlis, Hamada Ahmed, Nermin Kahraman, Seyda Baydogan, et al. "Abstract 4262: MiR-873 is the master regulator of autophagy genes through a novel negative feedback mechanism mediated by Elongation factor 2 kinase (eEF-2K) and suppresses tumor growth and progression of triple negative breast cancer." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-4262.

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Bayraktar, Recep, Martin Pichler Pichler, Cristina Ivan, George Calin, and Bulent Ozpolat. "Abstract 1092: miR-603 acts as a tumor suppressor in triple-negative breast cancer and inhibits cell proliferation, invasiveness and tumorigenesis by targeting elongation factor 2-kinase (eEF2K)." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-1092.

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Parapia, L., A. Minford, and J. B. Hamilton. "MONOCLONAL PURIFIED FACTOR VIII:C (MONOCLATE) TREATMENT IN A PREVIOUSLY UNTREATED HAEMOPHILIA." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644846.

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Monoclate is a new generation of Factor VIII concentrate produced by purification using mouse monoclonal anti-Factor VIII:R antibody. As the- Factor VIII:C does not interact with the antibody it can be eluted by disrupting the Factor VIII:C - Factor VIII:R complex using a high concentration of calcium ions. The eluted Factor VIII:C is concentrated and purified. The method of manufacture has demonstrated efficacy in the elimination of infectious viral particles.The first “virgin” haemophiliac to be treated by this has completed 20 weeks follow-up. The patient, a child of 18 months with a Factor
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Roberts, Patrick Dean, and Scott Naro-Norman. "Automated Forming Outputs for Compound Curvature." In SNAME Maritime Convention. SNAME, 2024. http://dx.doi.org/10.5957/smc-2024-032.

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Many shipyards and fabricators have equipment supporting complex compound curve forming, which contain many manual processes where mistakes can occur through looking up data and interpreting data. When an error occurs, it is not immediately noticed and causes significant negative schedule impacts as well as costly production rework. The Nieland press is once such piece of equipment, it is an efficient and useful tool many shipyards and fabricators use to form compound curves and shape in plate. The Nieland press, like many presses of this type, are operated by an individual who uses a graphica
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Kumar, N., B. Varela, and H. Ghoneim. "Effective Damping of a Flexible-Matrix-Composite Laminate With a Negative Effective Poisson’s Ratio." In ASME 2015 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/imece2015-50365.

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Two very important factors which determine the effectiveness of a pump are its volumetric and energy efficiencies. Yin and Ghoneim constructed a prototype of a flexible body pump with a very high volumetric efficiency or pumping potential (the relative volume reduction due to a relative input stroke) [1]. The high volumetric efficiency is attributed to the geometry of the pump’s structure (hyperboloid) as well as the high negative effective Poisson’s ratio of the 3-layer ([θ/β/θ]) flexible-matrix-composite (carbon/polyurethane) laminate adopted for the body of the pump. The energy efficiency w
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Reports on the topic "Negative Elongation Factor complex"

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Weiss, David, and Neil Olszewski. Manipulation of GA Levels and GA Signal Transduction in Anthers to Generate Male Sterility. United States Department of Agriculture, 2000. http://dx.doi.org/10.32747/2000.7580678.bard.

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The original objectives of the research were: i. To study the role of GA in anther development, ii. To manipulate GA and/or GA signal transduction levels in the anthers in order to generate male sterility. iii. To characterize the GA signal transduction repressor, SPY. Previous studies have suggested that gibberellins (GAs) are required for normal anther development. In this work, we studied the role of GA in the regulation of anther development in petunia. When plants were treated with the GA-biosynthesis inhibitor paclobutrazol, anther development was arrested. Microscopic analysis of these
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Panta, Manisha, Padam Thapa, Md Hoque, et al. Application of deep learning for segmenting seepages in levee systems. Engineer Research and Development Center (U.S.), 2024. http://dx.doi.org/10.21079/11681/49453.

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Seepage is a typical hydraulic factor that can initiate the breaching process in a levee system. If not identified and treated on time, seepages can be a severe problem for levees, weakening the levee structure and eventually leading to collapse. Therefore, it is essential always to be vigilant with regular monitoring procedures to identify seepages throughout these levee systems and perform adequate repairs to limit potential threats from unforeseen levee failures. This paper introduces a fully convolutional neural network to identify and segment seepage from the image in levee systems. To th
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Lunn, Pete, Marek Bohacek, Jason Somerville, Áine Ní Choisdealbha, and Féidhlim McGowan. PRICE Lab: An Investigation of Consumers’ Capabilities with Complex Products. ESRI, 2016. https://doi.org/10.26504/bkmnext306.

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Executive Summary This report describes a series of experiments carried out by PRICE Lab, a research programme at the Economic and Social Research Institute (ESRI) jointly funded by the Central Bank of Ireland, the Commission for Energy Regulation, the Competition and Consumer Protection Commission and the Commission for Communications Regulation. The experiments were conducted with samples of Irish consumers aged 18-70 years and were designed to answer the following general research question: At what point do products become too complex for consumers to choose accurately between the good ones
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Chamovitz, Daniel, and Albrecht Von Arnim. Translational regulation and light signal transduction in plants: the link between eIF3 and the COP9 signalosome. United States Department of Agriculture, 2006. http://dx.doi.org/10.32747/2006.7696515.bard.

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The COP9 signalosome (CSN) is an eight-subunit protein complex that is highly conserved among eukaryotes. Genetic analysis of the signalosome in the plant model species Arabidopsis thaliana has shown that the signalosome is a repressor of light dependent seedling development as mutant Arabidopsis seedlings that lack this complex develop in complete darkness as if exposed to light. These mutant plants die following the seedling stage, even when exposed to light, indicating that the COP9 signalosome also has a central role in the regulation of normal photomorphogenic development. The biochemical
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Philosoph-Hadas, Sonia, Peter Kaufman, Shimon Meir, and Abraham Halevy. Signal Transduction Pathway of Hormonal Action in Control and Regulation of the Gravitropic Response of Cut Flowering Stems during Storage and Transport. United States Department of Agriculture, 1999. http://dx.doi.org/10.32747/1999.7695838.bard.

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Original objectives: The basic goal of the present project was to increase our understanding of the cellular mechanisms operating during the gravitropic response of cut flowers, for solving their bending problem without affecting flower quality. Thus, several elements operating at the 3 levels o the gravity-induced signal transduction pathway, were proposed to be examined in snapdragon stems according to the following research goals: 1) Signaling: characterize the signal transduction pathway leading to the gravitropic response, regarding the involvement of [Ca2+]cyt as a mediator of IAA moveme
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