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Journal articles on the topic 'Negative geotaxis'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Manley, C. J., and S. R. Shaw. "Geotaxis and Phototaxis in Elphidium Crispum (Protozoa: Foraminiferida)." Journal of the Marine Biological Association of the United Kingdom 77, no. 4 (1997): 959–67. http://dx.doi.org/10.1017/s0025315400038558.

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Laboratory experiments were carried out upon Elphidium crispum to determine the mechanism by which this species remains epifaunal, by investigating geotaxism, phototaxism, temporal influence and responses through ontogeny. Different size-classes of specimens were tested for phototaxism and geotaxism, over four and five months respectively. Specimens of the smallest size-class tested (250–355 μm) were significantly phototaxic and geotaxic. Significant positive phototaxism was demonstrated in all tests except one, with specimens in the size-class 500–1000 μm giving particularly significant resul

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Weinersmith, K. L., C. E. Brown, K. B. Clingen, M. C. Jacobsen, L. B. Topper, and R. F. Hechinger. "Euhaplorchis californiensis Cercariae Exhibit Positive Phototaxis and Negative Geotaxis." Journal of Parasitology 104, no. 3 (2018): 329. http://dx.doi.org/10.1645/17-80.

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BAILLY, YANN, FRANK CÉZILLY, and THIERRY RIGAUD. "Stage-dependent behavioural changes but early castration induced by the acanthocephalan parasite Polymorphus minutus in its Gammarus pulex intermediate host." Parasitology 145, no. 3 (2017): 260–68. http://dx.doi.org/10.1017/s0031182017001457.

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SUMMARYMultidimensionality in parasite-induced phenotypic alterations (PIPA) has been observed in a large number of host–parasite associations, particularly in parasites with complex life cycles. However, it is still unclear whether such a syndrome is due to the successive activation of independent PIPAs, or results from the synchronous disruption of a single mechanism. The aim of the present study was to investigate the onset and progression of two PIPAs (a behavioural alteration: reversion of geotaxis, and castration) occurring in the crustacean amphipod Gammarus pulex infected with the acan

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Bradbury, I. R., K. Gardiner, P. VR Snelgrove, S. E. Campana, P. Bentzen, and L. Guan. "Larval transport, vertical distribution, and localized recruitment in anadromous rainbow smelt (Osmerus mordax)." Canadian Journal of Fisheries and Aquatic Sciences 63, no. 12 (2006): 2822–36. http://dx.doi.org/10.1139/f06-164.

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We examined larval dispersal and behaviour in rainbow smelt (Osmerus mordax) from the Salmonier River estuary, Newfoundland, during 2003–2005. Riverine ichthyoplankton surveys indicate that larval transport into the estuary is restricted to a two-week period in late June. A passive drifter experiment and the spatial distribution of larvae and juveniles suggest limited dispersal and low export from the estuary. The estuary exhibited low inflow and stratification in summer and high inflow with a stable freshwater layer in fall. Summer and fall winds are primarily onshore. We hypothesised that la

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Chaudhary, Prakash, and Swati Dhande. "Evaluation of Neuroprotective effect of medicinal plants in Drosophila melanogaster model." Indian Journal of Pharmaceutical and Biological Research 6, no. 03 (2018): 09–12. http://dx.doi.org/10.30750/ijpbr.6.3.2.

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In this study, we investigated the neuroprotective effects of ethanolic extract of Bombax ceiba (EEBC) and ethanolic extract of Gymnemasylvestre (EEGS) against the toxicity induced by rotenone (ROT) in Drosophila melanogaster. Materials and Methods:Adult wild-type flies were concomitantly exposed to ROT (500 μM), EEBC (0.05% w/v and 0.1% w/v) and EEGS (0.05% w/v and 0.1% w/v) in the culture medium for 7 days. Results: ROT treated flies produced marked decreased in locomotor performance (i.e., climbing capability) in the negative geotaxis assay when compared to control group. EEBC and EEGS flie

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Moulin, Thiago C., Tijana Stojanovic, Rasika P. Rajesh, et al. "Effects of Transient Administration of the NMDA Receptor Antagonist MK-801 in Drosophila melanogaster Activity, Sleep, and Negative Geotaxis." Biomedicines 11, no. 1 (2023): 192. http://dx.doi.org/10.3390/biomedicines11010192.

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MK-801, also called dizocilpine, is an N-methyl-D-aspartate (NMDA) receptor antagonist widely used in animal research to model schizophrenia-like phenotypes. Although its effects in rodents are well characterised, little is known about the outcomes of this drug in other organisms. In this study, we characterise the effects of MK-801 on the locomotion, sleep, and negative geotaxis of the fruit fly Drosophila melanogaster. We observed that acute (24 h) and chronic (7 days) administration of MK-801 enhanced negative geotaxis activity in the forced climbing assay for all tested concentrations (0.1

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Tamberg, Laura, Mariliis Jaago, Kristi Säälik, et al. "Daughterless, the Drosophila orthologue of TCF4, is required for associative learning and maintenance of the synaptic proteome." Disease Models & Mechanisms 13, no. 7 (2020): dmm042747. http://dx.doi.org/10.1242/dmm.042747.

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ABSTRACTMammalian transcription factor 4 (TCF4) has been linked to schizophrenia and intellectual disabilities, such as Pitt–Hopkins syndrome (PTHS). Here, we show that similarly to mammalian TCF4, fruit fly orthologue Daughterless (Da) is expressed widely in the Drosophila brain. Furthermore, silencing of da, using several central nervous system-specific Gal4 driver lines, impairs appetitive associative learning of the larvae and leads to decreased levels of the synaptic proteins Synapsin (Syn) and Discs large 1 (Dlg1), suggesting the involvement of Da in memory formation. Here, we demonstrat

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Lowe, B. "The role of Ca2+ in deflection-induced excitation of motile, mechanoresponsive balancer cilia in the ctenophore statocyst." Journal of Experimental Biology 200, no. 11 (1997): 1593–606. http://dx.doi.org/10.1242/jeb.200.11.1593.

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Motile, mechanoresponsive cilia (balancers) in ctenophore statocysts, like vertebrate hair cells, are excited or inhibited depending upon the direction in which they are deflected. Balancers, however, may become either excited (beat rapidly) or inhibited (beat slowly) by deflection in the same direction, depending on the sign of ctenophore geotaxis (positive or negative). The beat frequency of many cilia is controlled by concentrations of Ca2+, membrane potential and neural input. How these factors affect deflection-induced ciliary beating in balancers was investigated. Deflection-induced exci

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Ruhela, Rakesh K., Shringika Soni, Phulen Sarma, Ajay Prakash, and Bikash Medhi. "Negative geotaxis: An early age behavioral hallmark to VPA rat model of autism." Annals of Neurosciences 26, no. 1 (2019): 25–31. http://dx.doi.org/10.5214/ans.0972.7531.260106.

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Linderman, Jessica A., Moria C. Chambers, Avni S. Gupta, and David S. Schneider. "Infection-Related Declines in Chill Coma Recovery and Negative Geotaxis in Drosophila melanogaster." PLoS ONE 7, no. 9 (2012): e41907. http://dx.doi.org/10.1371/journal.pone.0041907.

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Katarachia, Stamatia A., Sophia P. Markaki, Athanassios D. Velentzas, and Dimitrios J. Stravopodis. "Genetic Targeting of dSAMTOR, A Negative dTORC1 Regulator, during Drosophila Aging: A Tissue-Specific Pathology." International Journal of Molecular Sciences 24, no. 11 (2023): 9676. http://dx.doi.org/10.3390/ijms24119676.

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mTORC1 regulates mammalian cell metabolism and growth in response to diverse environmental stimuli. Nutrient signals control the localization of mTORC1 onto lysosome surface scaffolds that are critically implicated in its amino acid-dependent activation. Arginine, leucine and S-adenosyl-methionine (SAM) can serve as major mTORC1-signaling activators, with SAM binding to SAMTOR (SAM + TOR), a fundamental SAM sensor, preventing the protein’s (SAMTOR’s) inhibitory action(s) against mTORC1, thereby triggering its (mTORC1) kinase activity. Given the lack of knowledge regarding the role of SAMTOR in

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Taylor, Matthew J., and Richard I. Tuxworth. "Continuous tracking of startled Drosophila as an alternative to the negative geotaxis climbing assay." Journal of Neurogenetics 33, no. 3 (2019): 190–98. http://dx.doi.org/10.1080/01677063.2019.1634065.

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13

Ibraheem, Omodele, Tosin A. Oyewole, Adeola Adedara, et al. "Ackee (Blighia sapida K.D. Koenig) Leaves and Arils Methanolic Extracts Ameliorate CdCl2-Induced Oxidative Stress Biomarkers in Drosophila melanogaster." Oxidative Medicine and Cellular Longevity 2022 (November 14, 2022): 1–20. http://dx.doi.org/10.1155/2022/3235031.

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Different ethnomedical benefits have been documented on different parts of Ackee (Blighia sapida); however, their roles in ameliorating oxidative damages are not well established. CdCl2 inhibitory effects on some oxidative-stress biomarkers and ameliorative potentials of Ackee leaves (AL) and arils (AS) methanolic extracts were studied using Drosophila melanogaster as a model. One to 3-day-old D. melanogaster flies were orally exposed to different concentrations of CdCl2 in their diet for 7 days. The fly’s survival profile and negative geotaxis assays were subsequently analysed. Methanolic ext

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Salim, Mohamad Agus, and Muhammad Subandi. "Pengaruh Anti-Stres Jus Microgreens Ketumbar (Coriandrum sativum L.) Terhadap Lalat Buah (Drosophila melanogaster) yang Diinduksi Methotrexate." Al-Kauniyah: Jurnal Biologi 15, no. 2 (2022): 243–51. http://dx.doi.org/10.15408/kauniyah.v15i2.18959.

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AbstrakSaat ini, masyarakat dihadapkan pada kondisi kehidupan yang selalu mengganggu metabolisme normalnya dan mengurangi kebugaran tubuh yang dikenal dengan stres. Penelitian ini bertujuan untuk mengevaluasi kemampuan jus microgreens ketumbar (Coriandrum sativum L.) (JMK) sebagai agen anti-stres pada Drosophila melanogaster (selanjutnya disebut Drosophila) jantan tipe liar yang diinduksi methotrexate (MTX). Disiapkan empat kelompok perlakuan, yaitu kelompok pertama Drosophila yang tidak diberi perlakuan sebagai kontrol. Kelompok kedua, Drosophila yang mendapatkan perlakuan 10 ppm MTX, kelompo

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Kokott-Vuong, Alma, Jennifer Jung, Aaron T. Fehr, et al. "Increased Post-Hypoxic Oxidative Stress and Activation of the PERK Branch of the UPR in Trap1-Deficient Drosophila melanogaster Is Abrogated by Metformin." International Journal of Molecular Sciences 22, no. 21 (2021): 11586. http://dx.doi.org/10.3390/ijms222111586.

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Hypoxia is known to impair mitochondrial and endoplasmic reticulum (ER) homeostasis. Post-hypoxic perturbations of the ER proteostasis result in the accumulation of misfolded/unfolded proteins leading to the activation of the Unfolded Protein Response (UPR). Mitochondrial chaperone TNF receptor-associated protein 1 (TRAP1) is reported to preserve mitochondrial membrane potential and to impede reactive oxygen species (ROS) production thereby protecting cells from ER stress as well as oxidative stress. The first-line antidiabetic drug Metformin has been attributed a neuroprotective role after hy

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GARGANO, J., I. MARTIN, P. BHANDARI, and M. GROTEWIEL. "Rapid iterative negative geotaxis (RING): a new method for assessing age-related locomotor decline in." Experimental Gerontology 40, no. 5 (2005): 386–95. http://dx.doi.org/10.1016/j.exger.2005.02.005.

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Kadhim, Mohammed Jawad, Falah Muosa Kadhim AL-Rekabi, and Duriad Abdulhadi Abass. "The neurobehavioral and withdrawal effects of diazepam in adult male rats." Kufa Journal For Veterinary Medical Sciences 5, no. 2 (2014): 306–18. http://dx.doi.org/10.36326/kjvs/2014/v5i24184.

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The study conducted to evaluate the neurobehavioral effects and dependence in adult male rats which showed significant decrease (p<0.05) in exploration, vestibular system (increasing time of rotating on negative geotaxis apparatus), decrease cognition, short term memory, locomotors activity (decrease time of rotating on Rota rod apparatus), where these results was confirmed by histopathological changes of brain which represent by congestion, perivascular edema, focal gliosis and mononuclear cells infiltrations in groups treated with diazepam. The results of withdrawal study after one week o

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18

Ramadhan, M. J., S. Kharomah, S. Kharomah, et al. "Negative Geotaxis Assay in Three Drosophila Strains Consuming Bisphenol A: Duration and Number of Climbing Successes." IOP Conference Series: Earth and Environmental Science 1439, no. 1 (2025): 012010. https://doi.org/10.1088/1755-1315/1439/1/012010.

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Abstract Bisphenol A (BPA) is a substance that can migrate from polycarbonate plastic packaging to food or beverages. Several countries have banned the use of BPA in various food packaging, while other countries still have looser regulations. This study aims to analyze the effect of BPA consumption and strain type on the climbing performance of Drosophila melanogaster. Negative geotaxis assay was conducted on 3 groups of Drosophila: without BPA, consumed 0.25 mg/mL BPA, and consumed 0.50 mg/mL BPA. In the climbing duration, BPA did not have a significant effect (F = 1.682, p = 0.240), strain h

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Sudo, Masaaki, and Masahiro Osakabe. "Geotaxis and leaf-surface preferences mitigate negative effects of a predatory mite on an herbivorous mite." Experimental and Applied Acarology 59, no. 4 (2012): 409–20. http://dx.doi.org/10.1007/s10493-012-9622-1.

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Mogami, Yoshihiro, Chieko Oobayashi, Tomoko Yamaguchi, Yumi Ogiso, and Shoji A. Baba. "Negative Geotaxis in Sea Urchin Larvae: A Possible Role of Mechanoreception in the Late Stages of Development." Journal of Experimental Biology 137, no. 1 (1988): 141–56. http://dx.doi.org/10.1242/jeb.137.1.141.

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Negative geotactic behaviour of sea urchin larvae at various developmental stages from blastula to pluteus was analysed by means of time-exposure dark-field photography of the swimming behaviour of individual larvae. Significant differences in the patterns of behaviour, such as swimming direction and speed, were demonstrated between the early stages (up to the gastrula) and the pluteus, although larvae at any developmental stage showed negative geotactic migration. Larvae in the early stages swam at speeds that varied as a function of the swimming direction with respect to gravity, faster down

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Femi-Akinlosotu, Omowumi Moromoke, and Matthew Temitayo Shokunbi. "Changes in Neuronal Density of the Sensorimotor Cortex and Neurodevelopmental Behaviour in Neonatal Mice with Kaolin-Induced Hydrocephalus." Pediatric Neurosurgery 55, no. 5 (2020): 244–53. http://dx.doi.org/10.1159/000510603.

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<b><i>Introduction:</i></b> Hydrocephalus is a disorder in which the circulation of cerebrospinal fluid is altered in a manner that leads to its accumulation in the ventricles and subarachnoid space. Its impact on the neuronal density and networks in the overlying cerebral cortex in a time-dependent neonatal hydrocephalic process is largely unknown. We hypothesize that hydrocephalus will affect the cytoarchitecture of the cerebral cortical mantle of neonatal hydrocephalic mice, which will in turn modify sensorimotor processing and neurobehaviour. <b><i>Objec

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MONGEAU, R., and C. A. MARSDEN. "EFFECTS OF 5-HT RECEPTOR LIGANDS ON RAT PUP ULTRASONIC VOCALIZATIONS, BEHAVIOUR, RECTAL TEMPERATURE AND NEGATIVE GEOTAXIS." Behavioural Pharmacology 7, Supplement 1 (1996): 71. http://dx.doi.org/10.1097/00008877-199605001-00160.

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Dilliane, Crisley Cheuczuk, Freitas Suelen, Vaz Jaqueline, and Luciano Braguini Welligton. "Valeriana officinalis and melatonin: Evaluation of the effects in Drosophila melanogaster rapid iterative negative geotaxis (RING) test." Journal of Medicinal Plants Research 11, no. 44 (2017): 703–12. http://dx.doi.org/10.5897/jmpr2017.6492.

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Yost, Ryley T., J. Wesley Robinson, Carling M. Baxter, et al. "Abnormal Social Interactions in a Drosophila Mutant of an Autism Candidate Gene: Neuroligin 3." International Journal of Molecular Sciences 21, no. 13 (2020): 4601. http://dx.doi.org/10.3390/ijms21134601.

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Social interactions are typically impaired in neuropsychiatric disorders such as autism, for which the genetic underpinnings are very complex. Social interactions can be modeled by analysis of behaviors, including social spacing, sociability, and aggression, in simpler organisms such as Drosophila melanogaster. Here, we examined the effects of mutants of the autism-related gene neuroligin 3 (nlg3) on fly social and non-social behaviors. Startled-induced negative geotaxis is affected by a loss of function nlg3 mutation. Social space and aggression are also altered in a sex- and social-experienc

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Sarkar, Ambalika, Kayode Balogun, Monica S. Guzman Lenis, Sebastian Acosta, Howard T. Mount, and Lena Serghides. "In utero exposure to protease inhibitor-based antiretroviral regimens delays growth and developmental milestones in mice." PLOS ONE 15, no. 11 (2020): e0242513. http://dx.doi.org/10.1371/journal.pone.0242513.

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Antiretroviral therapy (ART) in pregnancy has dramatically reduced HIV vertical transmission rates. Consequently, there is a growing number of children that are HIV exposed uninfected (CHEUs). Studies suggest that CHEUs exposed in utero to ART may experience developmental delays compared to their peers. We investigated the effects of in utero ART exposure on perinatal neurodevelopment in mice, through assessment of developmental milestones. Developmental milestone tests (parallel to reflex testing in human infants) are reflective of brain maturity and useful in predicting later behavioral outc

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Pearce, B. L., J. A. Owens, M. Dziadek, et al. "162. THE EFFECT OF MATERNAL FOLIC ACID SUPPLEMENTATION THROUGHOUT PREGNANCY ON NEURODEVELOPMENT, MOTOR FUNCTION AND BEHAVIOUR OF PROGENY IN THE RAT." Reproduction, Fertility and Development 21, no. 9 (2009): 80. http://dx.doi.org/10.1071/srb09abs162.

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Background: Maternal folic acid supplementation (mFAS) during early pregnancy is recommended to reduce the incidence of neural tube defects and has recently been associated with improved neurodevelopment in children. However, the effect on neurodevelopment of mFAS from before conception and throughout pregnancy is unknown. We examined the effect of mFAS throughout the gestational period on postnatal growth, neurodevelopment and early adult motor function and behaviour in rat offspring. Methods: Female Wistar Rats were fed either a control (folic acid 2mg/kg, n=6) or moderate mFAS diet (folic a

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Bhocal, Usha, Bijender Singh Sabharwal, and Veer Bhan. "Declines In Chill Coma Recovery and Negative Geotaxis Due To an Enamopathogen in Drosophila Melanogaster the Fruit Flies." IOSR Journal of Biotechnology and Biochemistry 03, no. 03 (2017): 25–31. http://dx.doi.org/10.9790/264x-03032531.

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Pham, Hanh M., Anna Xu, Samuel E. Schriner, Evgueni A. Sevrioukov, and Mahtab Jafari. "Cinnamaldehyde Improves Lifespan and Healthspan in Drosophila melanogaster Models for Alzheimer’s Disease." BioMed Research International 2018 (August 29, 2018): 1–9. http://dx.doi.org/10.1155/2018/3570830.

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Cinnamon extract has been reported to have positive effects in fruit fly and mouse models for Alzheimer’s disease (AD). However, cinnamon contains numerous potential active compounds that have not been individually evaluated. The main objective of this study was to evaluate the impact of cinnamaldehyde, a known putative active compound in cinnamon, on the lifespan and healthspan of Drosophila melanogaster models for Alzheimer’s disease, which overexpress Aβ42 and MAPT (Tau). We found that cinnamaldehyde significantly improved the lifespan of both AD and non-AD flies. Cinnamaldehyde also improv

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Deiró, Teresa Cristina Bomfim de Jesus, Judelita Carvalho, Elizabeth do Nascimento, et al. "Neonatal exposure to citalopram, a serotonin selective reuptake inhibitor, programs a delay in the reflex ontogeny in rats." Arquivos de Neuro-Psiquiatria 66, no. 3b (2008): 736–40. http://dx.doi.org/10.1590/s0004-282x2008000500025.

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Serotonin influences the growth and development of the nervous system, as well as its behavioral manifestations. The possibility exists that increased brain serotonin availability in young animals modulates their neuro-behavioral responses. This study investigated the body weight gain and reflex ontogeny of neonatal rats treated during the suckling period with two doses of citalopram (5 mg, or 10 mg/kg, sc, daily). The time of the appearance of reflexes (palm grasp righting, free-fall righting, vibrissa placing, auditory startle response, negative geotaxis and cliff avoidance) as well as the b

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Rhodenizer, Devin, Ian Martin, Poonam Bhandari, Scott D. Pletcher, and Mike Grotewiel. "Genetic and environmental factors impact age-related impairment of negative geotaxis in Drosophila by altering age-dependent climbing speed." Experimental Gerontology 43, no. 8 (2008): 739–48. http://dx.doi.org/10.1016/j.exger.2008.04.011.

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Ramirez, Ruby Liane, and Linda Patia Spear. "Ontogeny of ethanol-induced motor impairment following acute ethanol: Assessment via the negative geotaxis reflex in adolescent and adult rats." Pharmacology Biochemistry and Behavior 95, no. 2 (2010): 242–48. http://dx.doi.org/10.1016/j.pbb.2010.01.013.

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Ahn, So Yoon, Dong Kyung Sung, Yun Sil Chang, et al. "BDNF-Overexpressing Engineered Mesenchymal Stem Cells Enhances Their Therapeutic Efficacy against Severe Neonatal Hypoxic Ischemic Brain Injury." International Journal of Molecular Sciences 22, no. 21 (2021): 11395. http://dx.doi.org/10.3390/ijms222111395.

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We investigated whether irradiated brain-derived neurotropic factor (BDNF)-overexpressing engineered human mesenchymal stem cells (BDNF-eMSCs) improve paracrine efficiency and, thus, the beneficial potency of naïve MSCs against severe hypoxic ischemic (HI) brain injury in newborn rats. Irradiated BDNF-eMSCs hyper-secreted BDNF > 10 fold and were >5 fold more effective than naïve MSCs in attenuating the oxygen-glucose deprivation-induced increase in cytotoxicity, oxidative stress, and cell death in vitro. Only the irradiated BDNF-eMSCs, but not naïve MSCs, showed significant attenuating e

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Sanches, E. S. A. M., F. Tsuzuki, F. Joinhas, G. B. Figueiras, E. G. Moreira, and M. J. S. Salles. "Paternal exposure to bupropion affects postnatal development in the offspring." Reproduction, Fertility and Development 31, no. 10 (2019): 1539. http://dx.doi.org/10.1071/rd18403.

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The aim of this study was to evaluate whether paternal exposure to bupropion hydrochloride (BUP), an inhibitor of dopamine and noradrenaline reuptake, would affect the postnatal development of offspring. Male mice were divided into a BUP-treated (40mgkg−1day−1 by gavage, 45 days) or control (saline by gavage, 45 days) group (n=20 in each group). From Day 35 to Day 45 of treatment, males were allowed to mate with drug-naïve female mice. Postnatal development of the offspring (both sexes) was evaluated from Postnatal day (PND) 1 to PND60. Physical development parameters (weight gain, body length

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O Imosemi, Innocent, Adu Y. Olawande, Olatunde Owoeye, and Malomo AO. "Lead-induced oxidative stress in postnatal developing cerebellum of Wistar rats: role of aqueous extract of Cucumis sativus Linn and vitamin C." MOJ Anatomy & Physiology 7, no. 4 (2020): 104–13. http://dx.doi.org/10.15406/mojap.2020.07.00299.

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Lead (Pb) is one of the most abundant heavy metal whose toxicity causes environmental and health problems, with the brain being highly sensitive to lead toxicity. There is limited literature regarding the protection of the developing brain against lead-induced toxicity. However, plant-derived products with antioxidant activity have been useful in reducing lead-induced neurotoxicity. This study investigated the role of Cucumis sativus (C. sativus) (Cucumber) and vitamin C in lead-induced oxidative stress in postnatal developing cerebellum of Wistar rats. Twenty-five pregnant Wistar rats weighin

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Bugaeva, L. I., T. D. Denisova, Y. A. Mazanova, N. S. Melichova, and A. A. Ozerov. "POSTNATAL DEVELOPMENT OF POSTERITIES FROM FEMALE RATS TREATED WITH ADEPROFEN DURING PREGNANCY." Journal of Volgograd State Medical University 80, no. 4 (2021): 144–48. http://dx.doi.org/10.19163/1994-9480-2021-4(80)-144-148.

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In researches on the posterities of rats been born from rats of females who received adeprofen substance during pregnancy (a new analogue of the purine nucleoside adenosine) at a dose of 150 mg/kg (15 times the therapeutic dose), it is not established differences with the control by body weight increase, but at it, a noting statistically significant advance of ear otlipanie, eye opening and sensory-motor reflexes maturation, such as: formation of "negative geotaxis,"pupil reflex, "visual stimulus-induced cliff avoidance," and "turning over in free fall". In behavioral activity, in the posterit

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Ringim, Ahmad Halilu, Marta Vicente Crespo, and Barkat Ali Khan. "Toxicity study of Warbugia ugandensis used by traditional healers to treat Herpes zoster in HIV patients using Drosophila melanogaster as a model." Journal of Contemporary Pharmacy 1, no. 1 (2017): 1–7. http://dx.doi.org/10.56770/jcp201701.

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Objectives: To carryout toxicity study of Warbugia ugandensis, also to participate in the compilation of ethnopharmacological knowledge of Rukararwe and makes it available for future research, and also to avail the healers with the information on scientific literature. Methods: Different concentrations of aqueous and ethanol extracts of Warbugia ugandensis with or without food were fed on Drosophila melanogaster and acute toxicity, locomotion assay, longevity study of the flies was done in 3 replicates, together with preliminary phytochemical screening of different extracts. Results: Tradition

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Walker, Richard F., Frederick J. Guerriero, and Patrick J. Wier. "Design of a Primary Screen for Developmental Neurotoxicity." Toxicology and Industrial Health 5, no. 2 (1989): 231–45. http://dx.doi.org/10.1177/074823378900500208.

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A battery of tests was devised for routine use as a primary screen for developmental neurotoxicity. The battery was divided into pre-weaning and postweaning tests using rats as subjects. Since the rat CNS is structurally incomplete at birth, preweaning tests were predominantly physical, using specific landmarks of somatic maturation and regional brain growth as indices of normal development. Pupillary responses to light and positional responses to gravity (negative geotaxis) were also included in the preweaning battery to monitor reflex behavior, a relatively simple CNS function. The postweani

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Filošević Vujnović, Ana, Sara Čabrijan, Martina Mušković, Nela Malatesti, and Rozi Andretić Waldowski. "Systemic Effects of Photoactivated 5,10,15,20-tetrakis(N-methylpyridinium-3-yl) Porphyrin on Healthy Drosophila melanogaster." BioTech 13, no. 3 (2024): 23. http://dx.doi.org/10.3390/biotech13030023.

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Porphyrins are frequently employed in photodynamic therapy (PDT), a non-invasive technique primarily utilized to treat subcutaneous cancers, as photosensitizing agents (PAs). The development of a new PA with improved tissue selectivity and efficacy is crucial for expanding the application of PDT for the management of diverse cancers. We investigated the systemic effects of 5,10,15,20-tetrakis(N-methylpyridinium-3-yl)-porphyrin (TMPyP3) using Drosophila melanogaster adult males. We established the oral administration schedule and demonstrated that TMPyP3 was absorbed and stored higher in neuron

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Valéria Soares de Araújo Pinho, Francisca, Gustavo Felipe da Silva, Giulianna Echeverria Macedo, et al. "Phytochemical Constituents and Toxicity ofDuguetia furfuraceaHydroalcoholic Extract inDrosophila melanogaster." Evidence-Based Complementary and Alternative Medicine 2014 (2014): 1–11. http://dx.doi.org/10.1155/2014/838101.

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Duguetia furfuraceais frequently used as a medicinal plant in Brazil. However, studies have evidenced its cytotoxic, bactericide, and antitumor activities. In the present study we aimed to evaluate the potential toxicity of hydroalcoholic leaves extracts ofD. furfuracea(HEDF) in aDrosophila melanogastermodel. Toxicity was assessed as changes in locomotor performance, mitochondrial activity, oxidative stress, MAPKs phosphorylation, and apoptosis induction after exposure to HEDF concentrations (1–50 mg/mL) for 7 days. The phytoconstituents of the plant were screened for the presence of alkaloids

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Giorgi, Roberta, Cainá Corrêa do Amaral, Renata Leivas de Oliveira, et al. "Nutritional programming of physical development and bone growth of offspring by a maternal high-fat diet." Revista Eletrônica Acervo Saúde 24, no. 2 (2024): e14837. http://dx.doi.org/10.25248/reas.e14837.2024.

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Objective: Investigate the influence of a maternal extended high-fat diet (HFD) consumption, an animal model for the human Western diet pattern, combined to preconceptional obesity on offspring development and growth. Methods: Female Wistar rats were subjected to HFD (52% energy from fat - primarily sourced from lard) or a control diet (12% energy from fat) from 37 days of life until the end of lactation. The dams in the HFD group were obese at the time of mating. Post-weaning, all offspring consumed a standardized diet. Somatic growth, physical maturation, neurobehavioral assessments, locomot

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Liu, Haiyan, Meng Han, Qingyi Li, Xiao Zhang, Wen-An Wang та Fu-De Huang. "Automated rapid iterative negative geotaxis assay and its use in a genetic screen for modifiers of Aβ42-induced locomotor decline in Drosophila". Neuroscience Bulletin 31, № 5 (2015): 541–49. http://dx.doi.org/10.1007/s12264-014-1526-0.

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Parent-Vachon, Madeleine, Francis Beaudry, Denise Carrier, Graziella Di Cristo, and Pascal Vachon. "The Effects of Exercise on Pain and Reproductive Performance in Female Pregnant Mice With Neuropathic Pain." Biological Research For Nursing 21, no. 5 (2019): 500–509. http://dx.doi.org/10.1177/1099800419857812.

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Pain can have negative, physiological and psychological impacts on pregnancy. Pregnant women are fearful of using pain medication because of teratogenic effects. In this study, we evaluated whether exercise could lower pain sensitivity in pregnant mice with neuropathic pain and reduce the negative effects of maternal pain on newborns. We randomly assigned 32 female mice to one of four groups (eight mice/group): Sham surgery with standard environment (SE) or enriched environment (EE) or spare nerve injury (SNI) with SE or EE. Mice in EE groups had access to an exercise wheel. Mothers were evalu

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Li, Chong, Guney Bademci, Asli Subasioglu, et al. "Dysfunction of GRAP, encoding the GRB2-related adaptor protein, is linked to sensorineural hearing loss." Proceedings of the National Academy of Sciences 116, no. 4 (2019): 1347–52. http://dx.doi.org/10.1073/pnas.1810951116.

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We have identified a GRAP variant (c.311A>T; p.Gln104Leu) cosegregating with autosomal recessive nonsyndromic deafness in two unrelated families. GRAP encodes a member of the highly conserved growth factor receptor-bound protein 2 (GRB2)/Sem-5/drk family of proteins, which are involved in Ras signaling; however, the function of the growth factor receptor-bound protein 2 (GRB2)-related adaptor protein (GRAP) in the auditory system is not known. Here, we show that, in mouse, Grap is expressed in the inner ear and the protein localizes to the neuronal fibers innervating cochlear and utricular

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Norton, Stata. "Correlation of Cerebral Cortical Morphology with Behavior." Toxicology and Industrial Health 5, no. 2 (1989): 247–60. http://dx.doi.org/10.1177/074823378900500209.

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Association between functional damage and damage to the central nervous system from toxic agents can be used to determine the value of behavioral tests as predictors of damage to the nervous system. Variability in data from behavioral tests may be caused, in part, by varying levels of structural differences in the nervous system. Stepwise multiple regression is one method for analyzing the relationship between variability in data resulting from linkage between functional and morphological or other parameters of the structure of the nervous system. As an example, the predictive value of four be

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Ishikawa, Takuji, Tomoyuki Tanaka, Yohsuke Imai, Toshihiro Omori, and Daiki Matsunaga. "Deformation of a micro-torque swimmer." Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences 472, no. 2185 (2016): 20150604. http://dx.doi.org/10.1098/rspa.2015.0604.

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The membrane tension of some kinds of ciliates has been suggested to regulate upward and downward swimming velocities under gravity. Despite its biological importance, deformation and membrane tension of a ciliate have not been clarified fully. In this study, we numerically investigated the deformation of a ciliate swimming freely in a fluid otherwise at rest. The cell body was modelled as a capsule with a hyperelastic membrane enclosing a Newtonian fluid. Thrust forces due to the ciliary beat were modelled as torques distributed above the cell body. The effects of membrane elasticity, the asp

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Ismaila, Muhammad Sani, Kamaldeen Olalekan Sanusi, Uwaisu Iliyasu, et al. "Antioxidant and Anti-Inflammatory Properties of Quail Yolk Oil via Upregulation of Superoxide Dismutase 1 and Catalase Genes and Downregulation of EIGER and Unpaired 2 Genes in a D. melanogaster Model." Antioxidants 13, no. 1 (2024): 75. http://dx.doi.org/10.3390/antiox13010075.

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Quail egg yolk oil (QEYO) has a rich history of medicinal use, showcasing heightened antioxidant and bioactive properties in our prior studies. This positions QEYO as a promising candidate for therapeutic and cosmetic applications. In this investigation, QEYO was extracted using ethanol/chloroform and 2-propanol/hexane solvents. GC–MS and FTIR analyses quantified 14 major bioactive compounds in the ethanol/chloroform fraction and 12 in the 2-propanol/hexane fraction. Toxicity evaluations in fruit flies, spanning acute, sub chronic, and chronic exposures, revealed no adverse effects. Negative g

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Azpurua, Jorge, Enas Gad El-Karim, Marvel Tranquille, and Josh Dubnau. "A behavioral screen for mediators of age-dependent TDP-43 neurodegeneration identifies SF2/SRSF1 among a group of potent suppressors in both neurons and glia." PLOS Genetics 17, no. 11 (2021): e1009882. http://dx.doi.org/10.1371/journal.pgen.1009882.

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Cytoplasmic aggregation of Tar-DNA/RNA binding protein 43 (TDP-43) occurs in 97 percent of amyotrophic lateral sclerosis (ALS), ~40% of frontotemporal dementia (FTD) and in many cases of Alzheimer’s disease (AD). Cytoplasmic TDP-43 inclusions are seen in both sporadic and familial forms of these disorders, including those cases that are caused by repeat expansion mutations in the C9orf72 gene. To identify downstream mediators of TDP-43 toxicity, we expressed human TDP-43 in a subset of Drosophila motor neurons. Such expression causes age-dependent deficits in negative geotaxis behavior. Using

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Salazar, Gerson Javier Torres, Assis Ecker, Stephen Adeniyi Adefegha, and José Galberto Martins da Costa. "Advances in Evaluation of Antioxidant and Toxicological Properties of Stryphnodendron rotundifolium Mart. in Drosophila melanogaster Model." Foods 11, no. 15 (2022): 2236. http://dx.doi.org/10.3390/foods11152236.

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This study investigated the flavonoid content, antioxidant activity, and toxicological properties of the acetone–water fraction of stem bark of Stryphnodendron rotundifolium Mart. (TFSR). The total flavonoid content and antioxidant activity were determined, as typified by DPPH● and ABTS●+ radical scavenging abilities, Fe3+ reducing antioxidant power (FRAP), relative antioxidant capacity (RAC), and the inhibition of thiobarbituric acid reactive species (TBARs) in Drosophila melanogaster tissue. Toxicity and locomotor functions were evaluated in adult D. melanogaster flies through aging and surv

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Mu, Chunlong, Angela Pochakom, Raylene A. Reimer, et al. "Addition of Prebiotics to the Ketogenic Diet Improves Metabolic Profile but Does Not Affect Seizures in a Rodent Model of Infantile Spasms Syndrome." Nutrients 14, no. 11 (2022): 2210. http://dx.doi.org/10.3390/nu14112210.

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The ketogenic diet (KD) is an effective treatment for infantile spasms syndrome (IS). However, the KD has implications for somatic growth, development, and the gut microbiota. The impact of incorporating a prebiotic fiber (PRE, oligofructose-enriched inulin, 0.8 g/dL) into a KD diet on spasms, developmental milestones, fecal gut microbiota, metabolites, and hippocampal mitochondrial metabolism were examined. Following IS induction, animals were randomized to KD or KD + PRE diets. A third group without IS and suckled by dams was included as a normally developing reference group (R). PRE inclusi

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Ryabova, Elena V., Pavel A. Melentev, Artem E. Komissarov, et al. "Morpho-Functional Consequences of Swiss Cheese Knockdown in Glia of Drosophila melanogaster." Cells 10, no. 3 (2021): 529. http://dx.doi.org/10.3390/cells10030529.

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Glia are crucial for the normal development and functioning of the nervous system in many animals. Insects are widely used for studies of glia genetics and physiology. Drosophila melanogaster surface glia (perineurial and subperineurial) form a blood–brain barrier in the central nervous system and blood–nerve barrier in the peripheral nervous system. Under the subperineurial glia layer, in the cortical region of the central nervous system, cortex glia encapsulate neuronal cell bodies, whilst in the peripheral nervous system, wrapping glia ensheath axons of peripheral nerves. Here, we show that

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