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Dissertations / Theses on the topic 'Neisseria gonorrhϾ'

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1

Gbenafa-Agossa, Clémence. "Prévalence et facteurs de risque des infections génitales à Neisseria gonorrhoeae et Chlamydia trachomatis chez les travailleuses de sexe au Bénin en 2003-2004 et évaluation d'un test rapide dans le dépistage de la gonococcie génitale." Master's thesis, Université Laval, 2006. http://hdl.handle.net/20.500.11794/18455.

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2

Berglund, Torsten. "Recent trends in the epidemiology of gonorrhoea in Sweden : the role of importation and core groups /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-692-1/.

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3

ROCK, JOHN PATRICK. "MOLECULAR BIOLOGY OF GONOCOCCAL DEATH FOLLOWING EXPOSURE TO THE GRANULE EXTRACTS OF HUMAN NEUTROPHILS (NEISSERIA GONORRHOEAE, PEPTIDOGLYCAN, MEMBRANE DAMAGE)." Diss., The University of Arizona, 1986. http://hdl.handle.net/10150/183844.

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Gonococci that have been phagocytized by human neutrophils are killed very effectively. While much research has focused on defining the microbicidal mechanisms of the neutrophil arsenal, substantially less is known regarding why phagocytized bacteria die. Gonococci were examined, at the molecular level, following exposure to human neutrophil granule extracts (GE) in an effort to discover the "lethal lesion", that injury to the bacterial cell which results in its death. The cytoplasm-based metabolism of GE-treated gonococci continues to function normally for at least 30 minutes, although these
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4

McMillan, Noto Jennifer. "Analysis of the mechanism of transferrin-iron acquisition by Neisseria gonorrhoeae." Online version unavailable until 9/16/2013, 2008. http://hdl.handle.net/10156/2294.

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5

Hernandez, Diana Raquel. "Regulation of Expression of a Neisseria Gonorrhoeae tRNA-Modification Enzyme (Gcp)." Diss., The University of Arizona, 2012. http://hdl.handle.net/10150/242381.

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Neisseria gonorrhoeae (Ng) encounters different microenvironments during its life-cycle. Some of these niches have different concentrations of oxygen, which influences the rate of Ng growth; as well as iron, an element essential for Ng survival. Differential expression of several proteins allows the bacteria to adapt to the diverse conditions it comes encounters. One protein affected by environmental changes during Ng growth is Gcp, a tRNA-modification enzyme essential for protein synthesis. To study the regulation of expression of Gcp, we first analyzed the sequence of its ORF, gcp. Orthologs
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6

Perry, Elizabeth Holly. "Association of ABO, Lewis and Secretor phenotypes and genotypes with Neisseria gonorrhoeae thesis submitted in (partial) fulfilment of the Master of Applied Science, Auckland University of Technology, November 2003." Full thesis. Abstract, 2003. http://puka2.aut.ac.nz/ait/theses/PerryE.pdf.

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7

DeRocco, Amanda Jean. "Molecular Analysis of Transferrin Binding Protein B in Neisseria Gonorrhoeae." VCU Scholars Compass, 2007. http://scholarscompass.vcu.edu/etd_retro/52.

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The transferrin iron acquisition system of Neisseria consists of two dissimilar proteins, transferrin binding protein A and B (TbpA and TbpB). TbpA and TbpB both specifically and independently bind human transferrin (Tf). TbpA is a TonB-dependent transporter, expression of which is necessary for Tf iron acquisition. In contrast, the lipoprotein TbpB is not necessary for iron internalization; however it makes this process more efficient. The role of TbpB in the transferrin iron acquisition system has not been completely elucidated. It has been suggested that TbpB is entirely surface expose
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8

Pickel, Donnie. "Investigating Complement Regulator Involvement in Innate Immune Evasion by Neisseria gonorrhoeae." Ohio University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1628181973757983.

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9

Wood, Megan Lindsay Falsetta. "Coping with stress: anaerobic respiratory and oxidative stress tolerance mechanisms are critical for Neisseria gonorrhoeae biofilm formation." Diss., University of Iowa, 2009. https://ir.uiowa.edu/etd/450.

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Many illnesses and infections are exacerbated and/or caused by biofilms. Neisseria gonorrhoeae, the etiologic agent of gonorrhea, is frequently asymptomatic in women, which can lead to persistent infection. Persistent infection can result in pelvic inflammatory disease, tubo-ovarian abscesses, infertility, and ectopic pregnancy. N. gonorrhoeae has been shown to form biofilms over glass, primary and immortalized cervical cells, and during natural cervical infection. Asymptomatic infection occurs in only 1% of infected males, and the infection site is subject to periodic rapid fluid flow, which
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10

Bergman, Peter. "Antimicrobial peptides and pathogenic Neisseria : experimental studies in mouse, man and rat /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-428-7/.

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11

Chakraborti, Srinjoy. "Therapeutic Antibody Against Neisseria gonorrhoeae Lipooligosaccharide, a Phase-variable Virulence Factor." eScholarship@UMMS, 2005. http://escholarship.umassmed.edu/gsbs_diss/905.

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Neisseria gonorrhoeae (Ng) which causes gonorrhea has become multidrug-resistant, necessitating the development of novel therapeutics and vaccines. mAb 2C7 which targets an epitope within an important virulence factor, the lipooligosaccharide (LOS), is a candidate therapeutic mAb. Ninety-four percent of clinical isolates express the 2C7-epitope which is also a vaccine target. Ng expresses multiple LOS(s) due to phase-variation (pv) of LOS glycosyltransferase (lgt) genes. mAb 2C7 reactivity requires a lactose extension from the LOS core Heptose (Hep) II (i.e. lgtG ‘ON’ [G+]). Pv results in HepI
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12

Chakraborti, Srinjoy. "Therapeutic Antibody Against Neisseria gonorrhoeae Lipooligosaccharide, a Phase-variable Virulence Factor." eScholarship@UMMS, 2017. https://escholarship.umassmed.edu/gsbs_diss/905.

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Neisseria gonorrhoeae (Ng) which causes gonorrhea has become multidrug-resistant, necessitating the development of novel therapeutics and vaccines. mAb 2C7 which targets an epitope within an important virulence factor, the lipooligosaccharide (LOS), is a candidate therapeutic mAb. Ninety-four percent of clinical isolates express the 2C7-epitope which is also a vaccine target. Ng expresses multiple LOS(s) due to phase-variation (pv) of LOS glycosyltransferase (lgt) genes. mAb 2C7 reactivity requires a lactose extension from the LOS core Heptose (Hep) II (i.e. lgtG ‘ON’ [G+]). Pv results in HepI
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13

Strange, Heather Ruth. "Mechanism of Iron Transport Employed by Neisseria Gonorrhoeae: Contribution of Ferric Binding Protein A." VCU Scholars Compass, 2007. http://scholarscompass.vcu.edu/etd_retro/80.

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FbpA is the periplasmic binding protein of the transferrin and lactoferrin-iron transport systems. FbpA is conserved among neisserial species and is required for Neisseria gonorrhoeae to sustain growth on transferrin and lactoferrin. The identification of other putative TonB-dependent outer membrane transporters suggests that gonococci may employ other uncharacterized iron uptake systems that do not require FbpA. Previous work in our lab demonstrated that gonococcal strain FA19 utilizes iron from a number of xenosiderophores of the catecholate and hydroxamate classes. In this study we cre
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14

Abshier, Patricia Alice. "Chlamydia Trachomatis and Neisseria Gonorrhoeae: Impact of Health Literacy on Prevalence." ScholarWorks, 2015. https://scholarworks.waldenu.edu/dissertations/1769.

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Millions of dollars are spent each year on preventing sexually transmitted diseases (STDs), yet the rates of chlamydia trachomatis (chlamydia) and neisseria gonorrhoeae (gonorrhea) infection continue to be high. Health literacy and its impact have been recognized in diabetes maintenance, control of hypertension, medical adherence, and reproductive health outcomes, yet no research has been conducted regarding the relationship between health literacy and chlamydia and gonorrhea prevalence. This study examined the relationship between health literacy scores and chlamydia and gonorrhea prevalence
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15

Yau, Chong-yee Miranda. "Comparison of two automated DNA amplification systems with culture for detection of Chlamydia trachomatis and Neisseria gonorrhoeae infections in symptomatic men." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B23829709.

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16

邱莊儀 and Chong-yee Miranda Yau. "Comparison of two automated DNA amplification systems with culture fordetection of Chlamydia trachomatis and Neisseria gonorrhoeaeinfections in symptomatic men." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31969872.

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17

Simms, Amy Nicole. "Examination of Neisseria gonorrhoeae opacity protein expression during experimental murine genital tract infection /." Download the dissertation in PDF, 2005. http://www.lrc.usuhs.mil/dissertations/pdf/Simms2005.pdf.

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18

Van, Vuuren S. "Antibiotic resistance in neisseria gonorrhoeae." Thesis, 2014. http://hdl.handle.net/10210/11746.

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19

Chen, Po-Lin, and 陳柏齡. "Clinical Management for Gonorrhea and Gene Analysis of Macrolide Resistance in Neisseria Gonorrhoeae." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/05201985905889859130.

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碩士<br>國立成功大學<br>臨床醫學研究所<br>96<br>Part I. Antimicrobial Therapy and Management for Gonorrhea in an Area with High-Level Antibiotic Resistance Abstract Background The choice of antimicrobial agents for gonorrhea is an important issue of public health in an area where the prevalence of drug resistance is high. Methods During 1999 to 2004, all Neisseria gonorrhoeae isolates causing clinical gonococcal disease were collected in the National Cheng Kung University Hospital. All stored isolates were subcultured in clinical microbiology laboratory and total 65 N. gonorrhoeae isolates were available. I
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20

Magooa, Mahlape Precious. "Detection and molecular epidemiology of ciprofloxacin-resistant Neisseria gonorrhoeae, using a real-time polymerase chain reaction (PCR)." Thesis, 2011. http://hdl.handle.net/10539/9187.

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MSc (Med), Clinical Microbiology and Infectious Diseases, Faculty of Health Sciences, University of the Witwaterstrand<br>Emergence and spread of resistance to ciprofloxacin among Neisseria gonorrhoeae strains has reduced the options of effective treatment for gonococcal infections and has become a concern worldwide. Up until 2008, ciprofloxacin was recommended first-line therapy for treatment of presumptive N. gonorrhoeae infections in South Africa. At the time this MSc project was conceived, ciprofloxacin was still used as first-line therapy for presumptive gonococcal infections. A re
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21

Francis, Ian Patrick. "The characterization of novel transgenic murine models of Neisseria gonorrhoeae infection and development of a natural outer membrane vesicle anti-gonococcal vaccine candidate." Thesis, 2018. https://hdl.handle.net/2144/29993.

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Untreatable gonorrhea, caused by fully antimicrobial resistant Neisseria gonorrhoeae (GC), is a major global health threat. While a vaccine would greatly help address this crisis, development of a GC vaccine is complicated by the lack of lab models of symptomatic gonorrhea. We hypothesized that overt disease in animal models of gonorrhea is limited by the human-restriction of gonococcal virulence factors, and the impact of the reproductive hormone cycle (estrus and diestrus phases). We tested these hypotheses by examining the host response to infection in transgenic mice expressing targets of
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22

"Epidemiologic Approaches to Understanding Gonorrhea Transmission Dynamics and the Development of Antimicrobial Resistance." Thesis, 2016. http://hdl.handle.net/10388/ETD-2016-02-2422.

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Globally, the incidence of infection caused by Neisseria gonorrhoeae is the second highest among the bacterial sexually transmitted infections. In Canada, declining rates during the 1990s suggested progress toward curbing gonorrhea; however, those have been increasing since 1999, with rates in Saskatchewan among the highest in the country. Infection can cause serious complications in men and women, and reported resistance to third-generation cephalosporins could lead to potentially untreatable infections. Increased understanding of gonorrhea transmission dynamics, sexual networks, and predicto
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23

Lin, Chia-Wei, and 林家偉. "Investigation of the antimicrobial usage for the treatment of gonorrhea and the epidemiology of antimicrobial resistance in Neisseria gonorrhoeae in Tainan, Taiwan." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/22443540750765132618.

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碩士<br>國立成功大學<br>公共衛生研究所<br>94<br>A physician-based sentinel surveillance on Neisseria gonorrhoeae (GC) infection has identified hidden epidemic of gonorrhea in a southern Taiwan city (Tainan), where there is no standard national treatment guideline and no definite patterns of antimicrobial resistance are available currently. Therefore, we conducted a study, and the goals of this study include: (1) to determine quinolone resistance in GC positive urine specimens from the surveillance by molecular techniques; and (2) to determine the antimicrobial resistance profiles in GC isolates from a medica
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