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Journal articles on the topic 'Neisseria gonorrhœæ'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Tabize Olivier, Mutendela, Freddy Munyololo Muganza, Leshweni Jeremia Shai, and Stanley Sechene Gololo. "Rutin Inhibits F, G, N and O gonorrhea strains, 2008 WHO N-gonorrhea Reference strains, in vitro." Interdisciplinary Research Journal and Archives 1 (December 16, 2020): 41–49. http://dx.doi.org/10.36966/irjar2020.13.

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Rutin was isolated from methanol extract of the aerial part of Asparagus suaveolens using precipitation method. South Africans use Asparagus suaveolens to treat gonorrhea infections. The obtained Nuclear Magnetic Resonance (NMR) and Liquid Chromatography-Mass Spectroscopy (LC-MS) data and visiting the published data on the isolation of rutin confirmed the structure. The 2008 WHO Neisseria gonorrhea reference strains were used to evaluate microbial activity of rutin against the gonorrhea strains. Rutin found to be bacteriostatic against WHO 2008 Neisseria gonorrhoea F, G, N and O strains with t

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DE, Bitet. "Neisseria Gonorrheae: A Cause of Male Infertility." Open Access Journal of Microbiology & Biotechnology 6, no. 1 (2021): 1–7. http://dx.doi.org/10.23880/oajmb-16000183.

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Background: Gonorrhoea is a sexually transmitted infection that is commonly related to male infertility. The infection affects sperm transport through the urinary tract and subsequent damage of the testicular tubes. The infection also impair sperm production as the infection is rarely asymptomatic and can be difficult to diagnose, it is possible that its contribution to male infertility is underestimated. Infection of the genitals results in a purulent (pus-like) discharge from the genitals which may be foul smelling, inflammation, redness, swelling, dysuria, and a burning sensation during uri

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3

Suay-García, Beatriz, and María-Teresa Pérez-Gracia. "Neisseria gonorrhoeae Infections." Pathogens 9, no. 8 (2020): 647. http://dx.doi.org/10.3390/pathogens9080647.

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Gonorrhea is a sexually transmitted disease with a high morbidity burden. Despite having guidelines for its treatment, the incidence of the disease follows an increasing trend worldwide. This is mainly due to the appearance of antibiotic-resistant strains, inefficient diagnostic methods and poor sexual education. Without an effective vaccine available, the key priorities for the control of the disease include sexual education, contact notification, epidemiological surveillance, diagnosis and effective antibiotic treatment. This Special Issue focuses on some of these important issues such as th

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Burhannuddin, Burhannuddin. "IDENTIFIKASI DAN UJI SENSITIVITAS BAKTERI Neisseria gonorrhoeae TERHADAP ANTIBIOTIK SEFIKSIM PADA PEKERJA SEKS KOMERSIAL DI PUSKESMAS II DENPASAR SELATAN." Meditory : The Journal of Medical Laboratory 9, no. 1 (2021): 1–11. http://dx.doi.org/10.33992/m.v9i1.1306.

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Gonorrhea is a sexually transmitted disease caused by Neisseria gonorrhoeae. Gonorrhea infection varies greatly in the community, especially in sexually active women. Infection cases in women are often asymptomatic, that can causes complication can easily occur. The aims of this study are to identify and determine sensitivity of Neisseria gonorrhoeae bacteria against cefixime antibiotics. This study was using a descriptive method and used 30 samples. Neisseria gonorrhoeae was isolatd from the vaginal swab sample of Commercial Sex Workers at Puskesmas II Denpasar Selatan. The cultured bacteria

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Setyowatie, Lita, Tantari SHW, and Inneke Yulian. "Susceptibility Pattern of Neisseria gonorrhoeae towards Cefixime and Ceftriaxone using Kirby-Bauer Method in Dr. Saiful Anwar General Hospital Malang." Berkala Ilmu Kesehatan Kulit dan Kelamin 32, no. 2 (2020): 103. http://dx.doi.org/10.20473/bikk.v32.2.2020.103-110.

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Background: Gonorrhea remains the second most common sexually transmitted infection (STI) in the world with an increasing number of cases. Oral cefixime and IM ceftriaxone are still the mainstay therapy for gonorrhea in Indonesia. However, previous studies suggested possible resistance to ceftriaxone and cefixime, which are the first-line treatment of gonorrhea. To date, there are no data available regarding the susceptibility of these antibiotics for the treatment of gonorrhea in Dr. Saiful Anwar General Hospital (RSSA) Malang. Purpose: Determine susceptibility pattern of Neisseria gonorrhoea

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Nepal, Anand, Kapil Subedi, Jitendra Shah, and Manoj Koirala. "Clinical and Bacteriological Profile of Male Patients with Urethral Discharge at Western Regional Hospital, Nepal." Medical Journal of Pokhara Academy of Health Sciences 2, no. 2 (2019): 178–82. http://dx.doi.org/10.3126/mjpahs.v2i2.28088.

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Background: Urethral discharge is a symptom of urethritis. Common organisms causing urethral discharge are Neisseria gonorrhea and Chlamydia trachomatis. Cephalosporines, Macrolides and Tetracycline groups of drugs are commonly used for the treatment. Materials and Methods: This was a prospective, cross sectional, observational study. The patients were enrolled from the Sexually Transmitted Infections clinic and also from the hospital laboratory in between the period of one year. All the male cases with urethral discharge at STI clinic in between this period were included for clinical ex

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7

Isa Adamu, Ibrahim, and Sulaiman Usman. "Mathematical Model for the Dynamics of Neisseria Gonorrhea Disease with Natural Immunity and Treatment Effects." Journal of Mathematics Research 10, no. 2 (2018): 151. http://dx.doi.org/10.5539/jmr.v10n2p151.

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Neisseria gonorrhea infection; a sexually transmitted disease, is caused primarily by a type of germ; a bacteria called neisseria gonorrhea. The infection is a major public health challenge today due to the high incidence of infections accompanied by a dwindling number of treatment options especially in developing and underdeveloped countries. In this paper, we developed a mathematical model for the transmission dynamics of neisseria gonorrhea infection and studied the effect of natural immunity and treatment as the only available control interventions on the spread of the disease in a populat

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Nadir qızı Kərimova, Sevinc. "Gonorrhea in women." NATURE AND SCIENCE 07, no. 02 (2021): 16–18. http://dx.doi.org/10.36719/2707-1146/07/16-18.

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Gonorrhea is a sexually transmitted infection. It is caused by gonococci of the genus Neisseria. The literal translation of the disease means "semen flow". Hygienic rules must be followed. Treatment must be carried out correctly. Key words: gonorrhea, preqnancy, gonococcus

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9

Hamid, Hamid, Dirk Runtuboi, and Lucky V. Waworuntu. "Uji Sensitivitas Neisseria gonorrhoeae terhadap Beberapa Antibiotik Pada Wanita Penjaja Seks (WPS) di Lokalisasi Tanjung Elmo Kabupaten Jayapura." JURNAL BIOLOGI PAPUA 6, no. 2 (2018): 60–69. http://dx.doi.org/10.31957/jbp.460.

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The purpose of this research is to study the sensitivity of quinolon antibiotic group against Neisseria gonorrhea. The bacteria which were found from endoservic vaginal from local sexual worker of Tanjung Elmo, Jayapura were isolated using neck duck sterile. This study was done on Health Laboratory of Jayapura from June to September 2013. The swab was planted on Thayer-Martin medium and incubated at 37 ºC for 2 x 24 hours. The grown colonies were sub-cultured to get the specific colonies. The bacterial identification is done by some rapid test including examination of grams, oxidation tests, b

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Queirós, Catarina Soares, and João Borges da Costa. "Gonorrhea: Antimicrobial Resistance and New Drugs." Journal of the Portuguese Society of Dermatology and Venereology 77, no. 3 (2019): 233–38. http://dx.doi.org/10.29021/spdv.77.3.1089.

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The global burden of sexually transmitted infections remains high, with significant associated morbidity and mortality. Gonorrhea is the second most notified sexually transmitted infection in Europe, and its incidence has been increasing in the last years. Although traditionally considered a treatable infection, antimicrobial resistance of Neisseria gonorrhoeaeincludes at present also macrolides, tetracyclines, sulfonamides and trimethoprim combinations, quinolones, and even cephalosporins. These high levels of gonococcal resistance to antimicrobials resulting in untreatable infections in the

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Hook, Edward W., Lori Newman, George Drusano, et al. "Development of New Antimicrobials for Urogenital Gonorrhea Therapy: Clinical Trial Design Considerations." Clinical Infectious Diseases 70, no. 7 (2019): 1495–500. http://dx.doi.org/10.1093/cid/ciz899.

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Abstract Gonorrhea remains a major public health challenge, and current recommendations for gonorrhea treatment are threatened by evolving antimicrobial resistance and a diminished pipeline for new antibiotics. Evaluations of potential new treatments for gonorrhea currently make limited use of new understanding of the pharmacokinetic and pharmacodynamic contributors to effective therapy, the prevention of antimicrobial resistance, and newer designs for clinical trials. They are hampered by the requirement to utilize combination ceftriaxone/azithromycin therapy as the comparator regimen in noni

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Olivier, Mutendela Tabize, Freddy Munyololo Muganza, Leshweni Jeremia Shai, and Stanley Sechene Gololo. "In vitro Antigonorrhea Activity of the Aerial Part of Asparagus suaveolens n-Hexane Fraction and Palmitone as a Bioactive Compound." Natural Product Communications 11, no. 9 (2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100935.

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Asparagus suaveolens is a medicinal plant used in Lesotho and South Africa to treat epilepsy and gonorrhea. The current investigation identifies the compound responsible for the antiepileptic and antimicrobial properties as palmitone which showed antigonorrhea activities against WHO 2008 Neisseria gonorrhea F and O strains more than the standard used, gentamicin. These results support the traditional use of A. suaveolens for treatment of gonorrhea and epilepsy since palmitone is known as an anticonvulsant agent. This is the first study indicating the presence of palmitone in the Asparagus genu

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Jefferson, Amber, Amanda Smith, Pius S. Fasinu, and Dorothea K. Thompson. "Sexually Transmitted Neisseria gonorrhoeae Infections—Update on Drug Treatment and Vaccine Development." Medicines 8, no. 2 (2021): 11. http://dx.doi.org/10.3390/medicines8020011.

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Background: Sexually transmitted gonorrhea, caused by the Gram-negative diplococcus Neisseria gonorrhoeae, continues to be a serious global health challenge despite efforts to eradicate it. Multidrug resistance among clinical N. gonorrhoeae isolates has limited treatment options, and attempts to develop vaccines have not been successful. Methods: A search of published literature was conducted, and information extracted to provide an update on the status of therapeutics and vaccine development for gonorrheal infection. Results: Recommended pharmacological treatment for gonorrhea has changed mul

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Peace, Nakiwala, Ahabwe Elliot, Nseera Lawrence, Twiine Felix, and Richard Onyuthi Apecu. "Prevalence and antimicrobial susceptibility patterns of Neisseria gonorrhea among the Symptomatic Patients attending Outpatient Department in Lyatonde District Hospital Southwestern Uganda." International Journal of Scientific Reports 5, no. 2 (2019): 52. http://dx.doi.org/10.18203/issn.2454-2156.intjscirep20190252.

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<p class="abstract"><strong>Background:</strong> Neisseria gonorrhea is one of the neglected diseases of public health importance causing symptomatic, suppurative discharge in males and being asymptomatic in females. This cross-sectional study was aimed at determining the prevalence and susceptibility pattern of <em>Neisseria gonorrhea</em> to the commonly used antibiotics among symptomatic patients attending outpatient department in Lyatonde district hospital.</p><p class="abstract"><strong>Methods:</strong> Urethral and endocervical swabs

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Barbee, Lindley A., Olusegun O. Soge, Jennifer Morgan, et al. "Gentamicin Alone Is Inadequate to Eradicate Neisseria Gonorrhoeae From the Pharynx." Clinical Infectious Diseases 71, no. 8 (2019): 1877–82. http://dx.doi.org/10.1093/cid/ciz1109.

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Abstract Background Centers for Disease Control and Prevention (CDC) guidelines recommend 240 mg gentamicin plus 2 g azithromycin for the treatment of gonorrhea in cephalosporin-allergic patients. The efficacy of gentamicin alone in the treatment of pharyngeal gonorrhea is uncertain. Methods Between September 2018 and March 2019, we enrolled men who have sex with men with nucleic acid amplification test–diagnosed pharyngeal gonorrhea in a single-arm, unblinded clinical trial. Men received a single 360-mg intramuscular dose of gentamicin and underwent test of cure by culture 4–7 days later. The

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Waseem, Hafsa, Afnan Naeem, Sakhawat Ali, Sharjeel Sarfraz, Javaid Usman, and Mehreen Gilani. "MULTIPLEX POLYMERASE CHAIN REACTION (PCR) FOR THE DETECTION OF NEISSERIA GONORRHOEAE AND THE QUINOLONE RESISTANCE GENE IN PAKISTAN." PAFMJ 71, no. 3 (2021): 866–69. http://dx.doi.org/10.51253/pafmj.v71i3.4692.

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Objective: To detect Neisseria gonorrhoeae from the urine of male patients reporting with active urethral discharge using multiplex polymerase chain reaction (PCR). And the simultaneous detection of the quinolone resistance determining region (QRDR) on the Neisseria gonorrhoeae gene using multiplex polymerase chain reaction. Study Design: Cross sectional study. Place and Duration of Study: Microbiology department, Army Medical College Rawalpindi Pakistan, from Mar to Dec 2018. Methodology: Male patients with active urethral discharge with no past history of antibiotic use for

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17

Leduc, Isabelle, Kristie L. Connolly, Afrin Begum, et al. "The serogroup B meningococcal outer membrane vesicle-based vaccine 4CMenB induces cross-species protection against Neisseria gonorrhoeae." PLOS Pathogens 16, no. 12 (2020): e1008602. http://dx.doi.org/10.1371/journal.ppat.1008602.

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There is a pressing need for a gonorrhea vaccine due to the high disease burden associated with gonococcal infections globally and the rapid evolution of antibiotic resistance in Neisseria gonorrhoeae (Ng). Current gonorrhea vaccine research is in the stages of antigen discovery and the identification of protective immune responses, and no vaccine has been tested in clinical trials in over 30 years. Recently, however, it was reported in a retrospective case-control study that vaccination of humans with a serogroup B Neisseria meningitidis (Nm) outer membrane vesicle (OMV) vaccine (MeNZB) was a

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Hirk, Sonja, Sarah Lepuschitz, Adriana Cabal Rosel, et al. "Draft Genome Sequences of Interpatient and Intrapatient Epidemiologically Linked Neisseria gonorrhoeae Isolates." Genome Announcements 6, no. 16 (2018): e00319-18. http://dx.doi.org/10.1128/genomea.00319-18.

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ABSTRACT Neisseria gonorrhoeae is the causative agent of gonorrhea and was identified by the World Health Organization as an urgent public health threat due to emerging antibiotic resistance. Here, we report 13 draft genome sequences of N. gonorrhoeae isolates derived from two epidemiologically linked cases from Austria.

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Van Dijck, Christophe, Jolein G. E. Laumen, Sheeba S. Manoharan-Basil, and Chris Kenyon. "Commensal Neisseria Are Shared between Sexual Partners: Implications for Gonococcal and Meningococcal Antimicrobial Resistance." Pathogens 9, no. 3 (2020): 228. http://dx.doi.org/10.3390/pathogens9030228.

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Antimicrobial resistance in pathogenic Neisseria parallels reduced antimicrobial susceptibility in commensal Neisseria in certain populations, like men who have sex with men (MSM). Although this reduced susceptibility can be a consequence of frequent antimicrobial exposure at the individual level, we hypothesized that commensal Neisseria are transmitted between sexual partners. We used data from a 2014 microbiome study in which saliva and tongue swabs were taken from 21 couples (42 individuals). Samples were analyzed using 16S rRNA gene sequencing. We compared intimate partners with unrelated

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Goytia, Maira, Symone T. Thompson, Skylar V. L. Jordan, and Kacey A. King. "Antimicrobial Resistance Profiles of Human Commensal Neisseria Species." Antibiotics 10, no. 5 (2021): 538. http://dx.doi.org/10.3390/antibiotics10050538.

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Pathogenic Neisseria gonorrhoeae causes the sexually transmitted infection gonorrhea. N. gonorrhoeae has evolved high levels of antimicrobial resistance (AR) leading to therapeutic failures even in dual-therapy treatment with azithromycin and ceftriaxone. AR mechanisms can be acquired by genetic transfer from closely related species, such as naturally competent commensal Neisseria species. At present, little is known about the antimicrobial resistance profiles of commensal Neisseria. Here, we characterized the phenotypic resistance profile of four commensal Neisseria species (N. lactamica, N.

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Hook, E. W., G. B. Pinson, C. J. Blalock, and R. B. Johnson. "Dose-ranging study of CP-99,219 (trovafloxacin) for treatment of uncomplicated gonorrhea." Antimicrobial Agents and Chemotherapy 40, no. 7 (1996): 1720–21. http://dx.doi.org/10.1128/aac.40.7.1720.

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Thirty-nine patients with uncomplicated gonorrhea were randomized to receive single, oral 50-, 100-, or 200-mg doses of trovafloxacin (CP-99,219), a new quinolone antibiotic. All 31 evaluable patients were cured of infection. Trovafloxacin was well tolerated. The trovafloxacin MICs at which 50 and 90% of 36 Neisseria gonorrhoeae isolates are inhibited were 0.002 and 0.004 mg/liter, respectively (MIC range, < 0.0005 to 0.008 mg/liter). These preliminary studies suggest that trovafloxacin is effective for the treatment of uncomplicated gonorrhea at single oral doses as low as 50 mg.

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Chung, Gyung Tae, Jeong Sik Yoo, Hee Bok Oh, et al. "Complete Genome Sequence of Neisseria gonorrhoeae NCCP11945." Journal of Bacteriology 190, no. 17 (2008): 6035–36. http://dx.doi.org/10.1128/jb.00566-08.

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ABSTRACT Neisseria gonorrhoeae is an obligate human pathogen that is the etiological agent of gonorrhea. We explored variations in the genes of a multidrug-resistant N. gonorrhoeae isolate from a Korean patient in an effort to understand the prevalence, antibiotic resistance, and importance of horizontal gene transfer within this important, naturally competent organism. Here, we report the complete annotated genome sequence of N. gonorrhoeae strain NCCP11945.

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Pettus, Kevin, Samera Sharpe, and John R. Papp. "In VitroAssessment of Dual Drug Combinations To Inhibit Growth of Neisseria gonorrhoeae." Antimicrobial Agents and Chemotherapy 59, no. 4 (2015): 2443–45. http://dx.doi.org/10.1128/aac.04127-14.

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ABSTRACTThe development of resistance to first-line antimicrobial therapies has led to recommendations for combination therapies for the treatment of gonorrhea infection. Recent studies have shown the success of combination therapies in treating patients, but few have reported on thein vitroactivities of these drug combinations. Anin vitroassessment of azithromycin in combination with gentamicin demonstrated inhibition of growth and suggests that clinical trials may be warranted to assess the utility of this combination in treating gonorrhea infections.

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Sehgal, Virender N., and G. Srivastava. "Gonorrhea and the Story of Resistant Neisseria gonorrhoeae." International Journal of Dermatology 26, no. 4 (1987): 206–14. http://dx.doi.org/10.1111/j.1365-4362.1987.tb00901.x.

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Roochvarg, L. B., J. C. Lovchik, and C. M. Brown. "The pearynmx-whether to screen for Neisseria gonorrhea." Journal of Adolescent Health Care 11, no. 3 (1990): 275. http://dx.doi.org/10.1016/0197-0070(90)90403-o.

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Workneh, Meklit, Mohammed Lamorde, Francis Kakooza, et al. "High-Level Neisseria gonorrhea Resistance Detected in a Newly Implemented Surveillance Program in Kampala, Uganda." Open Forum Infectious Diseases 4, suppl_1 (2017): S103. http://dx.doi.org/10.1093/ofid/ofx163.091.

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Abstract Background Neisseria gonorrhea resistance is a growing problem in Uganda with recent data showing increasing ciprofloxacin resistance up to 100% in this population. The WHO Enhanced Gonococcal Antimicrobial Surveillance Programme (EGASP) was initiated in Uganda in September 2016 to monitor resistance trends. Methods Urethral swabs were collected from men presenting with urethral discharge to the five sentinel clinic sites from September 2016 to March 2017. Samples were transported to a reference laboratory site. Presumptive identification of N. gonorrhea was based on growth of typical

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Fitriany, Nasyifa Nurul, Raden Ganang Ibnusantosa, Titik Respati, Deis Hikmawati, and Tony S. Djajakusumah. "Pengetahuan tentang Dampak Infeksi Gonore pada Pasien Pria dengan Gonore." Jurnal Integrasi Kesehatan & Sains 1, no. 1 (2019): 1–5. http://dx.doi.org/10.29313/jiks.v1i1.4198.

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Gonore merupakan infeksi menular seksual yang disebabkan oleh Neisseria gonorrhoeae. Salah satu karakteristik yang memengaruhi seseorang terkena gonore antara lain pengetahuan mengenai infeksi gonore. Gonore memiliki komplikasi seperti epididimitis, orkitis, prostatitis, cowperitis, bahkan infertilitas. Di samping itu, gonore dapat meningkatkan angka kejadian HIV. Tujuan penelitian ini mengetahui karakteristik dan tingkat pengetahuan dampak infeksi gonore pada pasien pria dengan gonore berdasar atas karakteristik usia dan jenis pasangan di salah satu Klinik IMS di Kota Bandung periode Maret–Me

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Belda Junior, Walter, Paulo Eduardo Neves Ferreira Velho, Luiz Jorge Fagundes, and Marcelo Arnone. "Evaluation of the in vitro activity of six antimicrobial agents against Neisseria gonorrhoeae." Revista do Instituto de Medicina Tropical de São Paulo 49, no. 1 (2007): 55–58. http://dx.doi.org/10.1590/s0036-46652007000100010.

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Use of antimicrobials for the treatment of gonorrhea started in 1930 with the utilization of sulfonamides. With the years other drugs were used for its treatment such as penicillin, tetracycline, spectinomycin, and others. Although highly specific in the beginning, these drugs, with time did not show anymore the expected therapeutic results because of aspects of chromosomal and plasmid-mediated resistance. The purpose of this study was to evaluate the susceptibility of Neisseria gonorrhoeae strains to six drugs used for its treatment (penicillin, tetracycline, cefoxitin, thiamphenicol, spectin

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Workneh, Meklit, Matthew M. Hamill, Francis Kakooza, et al. "Antimicrobial Resistance of Neisseria Gonorrhoeae in a Newly Implemented Surveillance Program in Uganda: Surveillance Report." JMIR Public Health and Surveillance 6, no. 2 (2020): e17009. http://dx.doi.org/10.2196/17009.

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Background Neisseria gonorrhoeae (commonly known as gonorrhea) has developed resistance to all first-line therapy in Southeast Asia. East Africa has historically had absent or rudimentary gonorrhea surveillance programs and, while the existence of antimicrobial-resistant gonorrhea is recognized, the extent of its resistance is largely unknown. In 2016, the World Health Organization’s Enhanced Gonococcal Antimicrobial Surveillance Program (EGASP) was initiated in Uganda to monitor resistance trends. Objective This study characterizes gonorrhea and antibiotic resistance in a large surveillance p

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Hook, E. W., W. M. McCormack, D. Martin, R. B. Jones, K. Bean, and A. N. Maroli. "Comparison of single-dose oral grepafloxacin with cefixime for treatment of uncomplicated gonorrhea in men. The STD Study Group." Antimicrobial Agents and Chemotherapy 41, no. 8 (1997): 1843–45. http://dx.doi.org/10.1128/aac.41.8.1843.

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In a randomized open study, 351 male patients with uncomplicated gonorrhea were given single oral doses of grepafloxacin (400 mg) or cefixime (400 mg). In the 299 microbiologically evaluable patients, urethral infections were cured in 99% (147 of 149) of those receiving grepafloxacin and 97% (145 of 150) of those given cefixime. Eradication rates for both regimens were 100% in the 16% (47 of 299) of participants who were infected with penicillin-resistant Neisseria gonorrhoeae and 97% in the 21% (62 of 299) of participants infected with tetracycline-resistant strains. Grepafloxacin is a well-t

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Cehovin, Ana, Odile B. Harrison, Steven B. Lewis, et al. "Identification of Novel Neisseria gonorrhoeae Lineages Harboring Resistance Plasmids in Coastal Kenya." Journal of Infectious Diseases 218, no. 5 (2018): 801–8. http://dx.doi.org/10.1093/infdis/jiy240.

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AbstractBackgroundAfrica has the highest incidence of gonorrhea in the world. However, little is known about gonococcal populations in this continent or mechanisms of antimicrobial resistance (AMR).MethodsWhole-genome sequence data were analyzed from 103 Neisseria gonorrhoeae isolates from 73 patients, mainly men who have sex with men, from coastal Kenya. We annotated loci, defined the core genome, defined mechanisms of AMR, and performed phylogenetic analysis. For patients with multiple episodes of gonorrhea, we determined whether infections occurred with related strains.ResultsWe identified

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Wilkinson, Laura A., Michael T. Carter, Bethany A. Wattengel, Alan J. Lesse, John A. Sellick, and Kari A. Mergenhagen. "Societal factors contributing to infections caused by Chlamydia trachomatis and Neisseria gonorrhoeae in a veteran population." International Journal of STD & AIDS 32, no. 9 (2021): 845–51. http://dx.doi.org/10.1177/0956462421999276.

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Background: Veterans have a higher incidence of sexually transmitted infections (STIs) compared to the general population. The objective of this study is to evaluate the association of societal factors on the risk of chlamydia or gonorrhea. Methods: This retrospective cohort study evaluated data from Veteran Health Administration. Patients tested for chlamydia or gonorrhea between January 2009 and January 2019 were included. Descriptive statistics and regression were used to evaluate societal factors. Results: A total of 1,232,173 tests for chlamydia or gonorrhea were performed. There were 51,

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Chow, Eric P. F., Sepehr N. Tabrizi, Samuel Phillips, et al. "Neisseria gonorrhoeae Bacterial DNA Load in the Pharynges and Saliva of Men Who Have Sex with Men." Journal of Clinical Microbiology 54, no. 10 (2016): 2485–90. http://dx.doi.org/10.1128/jcm.01186-16.

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Neisseria gonorrhoeaecan be cultured in the saliva of individuals with pharyngeal gonorrhea. The aim of this study was to quantify the gonococcal bacterial DNA loads in the pharynges and saliva among men who have sex with men (MSM) with untreated pharyngeal gonorrhea. Untreated MSM who tested positive for pharyngeal gonorrhea by culture and returned for antibiotic treatment within 14 days at the Melbourne Sexual Health Centre between October 2014 and March 2015 were eligible for this study. The gonococcal bacterial DNA load was measured using real-time quantitative PCR. The median gonococcal b

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Akhtar, Rahat, Nadia Taj, Sumera Mehnaz, Aamir Furqan, Mehnaz Khakwani, and Hajira Masood. "SUBFERTILE WOMEN;." Professional Medical Journal 24, no. 04 (2017): 507–10. http://dx.doi.org/10.29309/tpmj/2017.24.04.1453.

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Objectives: To determine the frequency of factors leading to tubal blockagein subfertile women evaluated by laparoscopy. Study Design: Cross-sectional study. Period:Six months from 1 February 2015 to 31 July 2015. Setting: Department of Obstetrics &Gynaecology of Nishter Hospital Multan. Methods: Two hundred and eighty (280) marriedprimary subfertile females presenting with primary and secondary subfertility of age more than20 and less than 40 years were included. Laparoscopy was done in every patient. Data wasanalyzed by SPSS 19. Descriptive statistics was used to calculate mean+SD for co

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Feinberg, B. "Gonorrhea in little girls." Journal of obstetrics and women's diseases 7, no. 1 (2020): 83–85. http://dx.doi.org/10.17816/jowd7183-85.

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Since then, as vulvo-vaginitis in young girls began to manifest itself both epidemic and endemic, special attention has been paid to this disease. The first was Pott (1883), who pointed out that this disease is based on infection with tripe poison, vaccinated by mothers or close relatives; later and other authors: Widmark, Csri, Frnkel, and in recent times Prochownik, Pott, Dusch and Spaeth found diplococcus in the genital area of such girls, very similar to Neisser's gonococcus.

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Putra, Teri Ade, Raja Ayu Mahessya, Pradani Ayu Widya Purnama, and Reza Suriadinata. "Design of Expert System for Diagnosis of Gonorrhea Disease by using Web-Based Naïve Bayes Method." Journal of Computer Networks, Architecture and High Performance Computing 3, no. 2 (2021): 223–33. http://dx.doi.org/10.47709/cnahpc.v3i2.1026.

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Gonorrhea is a sexually transmitted disease caused by the bacterium Neisseria gonorrhea that infects the lining of the bladder, cervix, rectum, throat, and the whites of the eyes. This disease is spread through the bloodstream to other parts of the body, especially the skin and joints and is generally transmitted through sexual contact. Gonorrhea not only affects adult men and women, but babies and even newborns can get gonorrhea from their mothers. An expert system is a system that seeks to adopt human knowledge into computers, so that computers can solve problems like an expert. With this ex

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He, Yingxia, Song Zhang, Yingmiao Zhang, et al. "Distinct Patterns of Host Adherence by Neisseria gonorrhoeae Isolated from Experimental Gonorrhea." Canadian Journal of Infectious Diseases and Medical Microbiology 2021 (May 13, 2021): 1–9. http://dx.doi.org/10.1155/2021/7865405.

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Neisseria gonorrhoeae (N. gonorrhoeae, gonococci, or GC), the etiologic agent of gonorrhea, is a human-obligate bacterial pathogen. The GC surface contains pili that mediate the adherence to host cells. Studies have shown that GC pili, coded by pilin genes, undergo remarkable changes during human experimental gonorrhea, possibly generated by DNA phase variation during infection. The question that arises is whether the changes in pilins can alter the adherence capacity of N. gonorrhoeae to host cells. In this study, six variants initially isolated from male volunteers infected with one single c

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Krivosheev, N. P. "To the Neisser's gonococcus staining technique." Kazan medical journal 18, no. 2 (2021): 72–83. http://dx.doi.org/10.17816/kazmj79871.

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Soon after the appearance of the first message of Neisser about gonococcus as the causative agent of gonorrhea, a number of authors (Krause, Jlirschberg, cklund, Gama Pinto, Sternberg, Lustgarten, Hague r, Frnkel, etc.) opposed this doctrine with complete denial virulence and specificity of this microorganism).

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Bissessor, M., D. M. Whiley, D. M. Lee, et al. "Detection of Neisseria gonorrhoeae Isolates from Tonsils and Posterior Oropharynx." Journal of Clinical Microbiology 53, no. 11 (2015): 3624–26. http://dx.doi.org/10.1128/jcm.01647-15.

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We examined the factors influencing gonorrhea detection at the pharynx. One hundred men infected withNeisseria gonorrhoeaewere swabbed from the tonsils and posterior oropharynx.N. gonorrhoeaewas reisolated from the tonsils and posterior oropharynx in 62% and 52%, respectively (P= 0.041). Culture positivity was greater with higher gonococcal DNA loads at the tonsils (P= 0.001) and oropharynx (P< 0.001).N. gonorrhoeaecan be cultured from the tonsils and posterior oropharynx with greater isolation rates where gonococcal loads are higher.

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KRAUS, STEPHEN J., GLADYS H. REYNOLDS, and ROBERT T. ROLFS. "Therapy of Uncomplicated Gonorrhea Due to Antibiotic-Resistant Neisseria gonorrhoeae." Sexually Transmitted Diseases 15, no. 4 (1988): 234–43. http://dx.doi.org/10.1097/00007435-198810000-00010.

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Lo, Janice Y. C., K. M. Ho, Anna O. C. Leung, et al. "Ceftibuten Resistance and Treatment Failure of Neisseria gonorrhoeae Infection." Antimicrobial Agents and Chemotherapy 52, no. 10 (2008): 3564–67. http://dx.doi.org/10.1128/aac.00198-08.

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ABSTRACT Neisseria gonorrhoeae infections have been empirically treated in Hong Kong with a single oral 400-mg dose of ceftibuten since 1997. Following anecdotal reports of the treatment failure of gonorrhea with oral extended-spectrum cephalosporins, the current study was undertaken to determine the antimicrobial susceptibility pattern and molecular characteristics of isolates of N. gonorrhoeae among patients with putative treatment failure in a sexually transmitted disease clinic setting. Between October 2006 and August 2007, 44 isolates of N. gonorrhoeae were studied from patients identifie

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Humbert, Maria Victoria, and Myron Christodoulides. "Atypical, Yet Not Infrequent, Infections with Neisseria Species." Pathogens 9, no. 1 (2019): 10. http://dx.doi.org/10.3390/pathogens9010010.

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Neisseria species are extremely well-adapted to their mammalian hosts and they display unique phenotypes that account for their ability to thrive within niche-specific conditions. The closely related species N. gonorrhoeae and N. meningitidis are the only two species of the genus recognized as strict human pathogens, causing the sexually transmitted disease gonorrhea and meningitis and sepsis, respectively. Gonococci colonize the mucosal epithelium of the male urethra and female endo/ectocervix, whereas meningococci colonize the mucosal epithelium of the human nasopharynx. The pathophysiologic

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Jabeen, Kauser, Summiya Nizamuddin, Seema Irfan, Erum Khan, Faisal Malik, and Afia Zafar. "Increasing Trend of Resistance to Penicillin, Tetracycline, and Fluoroquinolone Resistance inNeisseria gonorrhoeaefrom Pakistan (1992–2009)." Journal of Tropical Medicine 2011 (2011): 1–5. http://dx.doi.org/10.1155/2011/960501.

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Emergence and spread of drug resistant Neisseria gonorrhoeae is global concern. We evaluated trends of antimicrobial resistance in Neisseria gonorrhoeae over years 1992–2009 in Pakistan. Resistance rates were compared between years (2007–2009) and (1992–2006). Antimicrobial susceptibility testing was performed and interpreted according to Clinical Laboratory Standards Institute (CLSI) criteria using the disk diffusion methodology against penicillin, ceftriaxone, tetracycline and ofloxacin. Additional antibiotics tested in 100 strains isolated during 2007–2009, included cefotaxime, cefoxitin, c

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Jeong, Jieun, Jae-Seok Kim, Junghyeon Lee, Yu Ri Seo, Eugene C. Yi, and Kristine M. Kim. "Neisseria gonorrhoeae Multivalent Maxibody with a Broad Spectrum of Strain Specificity and Sensitivity for Gonorrhea Diagnosis." Biomolecules 11, no. 3 (2021): 484. http://dx.doi.org/10.3390/biom11030484.

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Gonorrhea is one of the most common, but still hidden and insidious, sexually transmitted diseases caused by Neisseria gonorrhoeae (gonococci). However, the diagnosis and treatment of gonorrhea are hampered by antigenic variability among gonococci, the lack of acquired immunity, and antimicrobial resistance. Further, strains resistant to cephalosporins, including ceftriaxone, the last line of defense, represent a growing threat, which prompted us to develop gonococci-specific diagnostic antibodies with broad-spectrum binding to gonococci strains to generate gonorrhea-detecting reagents. This s

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Schwebke, J. R., W. Whittington, R. J. Rice, H. H. Handsfield, J. Hale, and K. K. Holmes. "Trends in susceptibility of Neisseria gonorrhoeae to ceftriaxone from 1985 through 1991." Antimicrobial Agents and Chemotherapy 39, no. 4 (1995): 917–20. http://dx.doi.org/10.1128/aac.39.4.917.

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The antimicrobial susceptibilities of 16,441 gonococcal isolates from Seattle-King County were determined for ceftriaxone, cefoxitin, penicillin G, and tetracycline. From 1985 to 1989, ceftriaxone, in combination with doxycycline, was increasingly used for treatment of gonorrhea, and by 1989, it was used as therapy for > 80% of cases in Seattle-King County. MICs of ceftriaxone correlated significantly (P < 0.001) with those of the other beta-lactam antibodies included in this study. Geometric mean MICs of penicillin G for isolates that did not produce beta-lactamase increased from 1985 t

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Dong, Huan, Hoa Thi Nguyen, Minh Binh Xuan Nguyen, et al. "The Impact of Recent Antibiotic Usage on Oropharyngeal Neisseria spp. in MSM of Hanoi, Vietnam." Open Forum Infectious Diseases 4, suppl_1 (2017): S105. http://dx.doi.org/10.1093/ofid/ofx163.099.

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Abstract Background Neisseria gonorrhea (NG) has a long history of gaining resistance to nearly all antimicrobials used for treatment since the 1930s, which makes susceptibility to last-line cephalosporins of dire importance. Horizontal gene transmission is highly prevalent among the Neisseria genus, with genetic fragments from common commensal Neisseria having been found in resistant NG strains. Globally, NG disproportionately affects men-who-have-sex-with-men (MSM) and nearly all ceftriaxone-resistant cases have been reported from pharyngeal samples. Our study aims to assess the impact of an

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Anderson, Mark T., Luke Byerly, Michael A. Apicella, and H. Steven Seifert. "Seminal Plasma Promotes Neisseria gonorrhoeae Aggregation and Biofilm Formation." Journal of Bacteriology 198, no. 16 (2016): 2228–35. http://dx.doi.org/10.1128/jb.00165-16.

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ABSTRACTNeisseria gonorrhoeaecauses the human-specific disease gonorrhea and is transmitted from person to person primarily via sexual contact. During transmission,N. gonorrhoeaeis often exposed to seminal fluid and must adapt to this change in environment. Previous work demonstrated that seminal fluid facilitatesN. gonorrhoeaemotility and alters epithelial cell interactions. In this study, exposure to seminal fluid was found to decrease surface adherence of gonococci in a manner that was independent of Opa adhesin proteins or type IV pilus retraction. Semen was also shown to cause dispersal o

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Barbee, Lindley A., Olusegun O. Soge, Negusse Ocbamichael, Angela LeClair, and Matthew R. Golden. "Single-Arm Open-Label Clinical Trial of Two Grams of Aztreonam for the Treatment of Neisseria gonorrhoeae." Antimicrobial Agents and Chemotherapy 65, no. 1 (2020): e01739-20. http://dx.doi.org/10.1128/aac.01739-20.

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ABSTRACTThe threat of ceftriaxone-resistant Neisseria gonorrhoeae necessitates new gonorrhea treatment regimens. Repurposing older antibiotics not routinely used for N. gonorrhoeae may expeditiously identify new therapies. Ideally, all recommended therapies should eradicate gonorrhea at the pharynx. Between April and September 2019, we enrolled men in an open-label, one-arm clinical trial of single-dose intramuscular aztreonam (2 g). Enrollment criterion included (i) nucleic acid amplification test (NAAT)-positive pharyngeal gonorrhea for ≤14 days or (ii) Gram stain-positive gonococcal urethri

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Zhou, Xiyou, Xi Gao, Peter M. Broglie, et al. "Hexa-Acylated Lipid A Is Required for Host Inflammatory Response to Neisseria gonorrhoeae in Experimental Gonorrhea." Infection and Immunity 82, no. 1 (2013): 184–92. http://dx.doi.org/10.1128/iai.00890-13.

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ABSTRACTNeisseria gonorrhoeaecauses gonorrhea, a sexually transmitted infection characterized by inflammation of the cervix or urethra. However, a significant subset of patients withN. gonorrhoeaeremain asymptomatic, without evidence of localized inflammation. Inflammatory responses toN. gonorrhoeaeare generated by host innate immune recognition ofN. gonorrhoeaeby several innate immune signaling pathways, including lipooligosaccharide (LOS) and other pathogen-derived molecules through activation of innate immune signaling systems, including toll-like receptor 4 (TLR4) and the interleukin-1β (I

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Cwikel, Julie G., Tal Lazer, Fernanda Press, and Simcha Lazer. "Sexually transmissible infections among female sex workers: an international review with an emphasis on hard-to-access populations." Sexual Health 5, no. 1 (2008): 9. http://dx.doi.org/10.1071/sh07024.

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Background: Women who work commercially in sex work (female sex workers [FSW]) are considered a high-risk group for sexually transmissible infections (STI), yet the level of reported pathogens varies in studies around the world. This study reviewed STI rates reported in 42 studies of FSW around the world published between 1995 and 2006 and analysed the trends and types of populations surveyed, emphasising difficult to access FSW populations. Methods:Studies were retrieved by PUBMED and other search engines and were included if two or more pathogens were studied and valid laboratory methods wer

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