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Journal articles on the topic 'Neisseria infections'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 February 2022

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1

Suay-García, Beatriz, and María-Teresa Pérez-Gracia. "Neisseria gonorrhoeae Infections." Pathogens 9, no. 8 (August 12, 2020): 647. http://dx.doi.org/10.3390/pathogens9080647.

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Gonorrhea is a sexually transmitted disease with a high morbidity burden. Despite having guidelines for its treatment, the incidence of the disease follows an increasing trend worldwide. This is mainly due to the appearance of antibiotic-resistant strains, inefficient diagnostic methods and poor sexual education. Without an effective vaccine available, the key priorities for the control of the disease include sexual education, contact notification, epidemiological surveillance, diagnosis and effective antibiotic treatment. This Special Issue focuses on some of these important issues such as the molecular mechanisms of the disease, diagnostic tests and different treatment strategies to combat gonorrhea.

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2

Lee, Hoan Jong. "Neisseria meningitidis Infections." Korean Journal of Pediatric Infectious Diseases 10, no. 1 (2003): 13. http://dx.doi.org/10.14776/kjpid.2003.10.1.13.

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3

Smith, Roxanne P., Biswaranjan Mohanty, Shakeel Mowlaboccus, Jason J. Paxman, Martin L. Williams, Stephen J. Headey, Geqing Wang, et al. "Structural and biochemical insights into the disulfide reductase mechanism of DsbD, an essential enzyme for neisserial pathogens." Journal of Biological Chemistry 293, no. 43 (September 4, 2018): 16559–71. http://dx.doi.org/10.1074/jbc.ra118.004847.

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The worldwide incidence of neisserial infections, particularly gonococcal infections, is increasingly associated with antibiotic-resistant strains. In particular, extensively drug-resistant Neisseria gonorrhoeae strains that are resistant to third-generation cephalosporins are a major public health concern. There is a pressing clinical need to identify new targets for the development of antibiotics effective against Neisseria-specific processes. In this study, we report that the bacterial disulfide reductase DsbD is highly prevalent and conserved among Neisseria spp. and that this enzyme is essential for survival of N. gonorrhoeae. DsbD is a membrane-bound protein that consists of two periplasmic domains, n-DsbD and c-DsbD, which flank the transmembrane domain t-DsbD. In this work, we show that the two functionally essential periplasmic domains of Neisseria DsbD catalyze electron transfer reactions through unidirectional interdomain interactions, from reduced c-DsbD to oxidized n-DsbD, and that this process is not dictated by their redox potentials. Structural characterization of the Neisseria n- and c-DsbD domains in both redox states provides evidence that steric hindrance reduces interactions between the two periplasmic domains when n-DsbD is reduced, thereby preventing a futile redox cycle. Finally, we propose a conserved mechanism of electron transfer for DsbD and define the residues involved in domain–domain recognition. Inhibitors of the interaction of the two DsbD domains have the potential to be developed as anti-neisserial agents.

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Jacinto, Teresa, Helena Rego, Juan Gonçalves, and Virgílio Paz Ferreira. "Artrite Séptica Meningocócica Primária em Lactente de Dois Meses." Acta Médica Portuguesa 28, no. 1 (February 27, 2015): 117. http://dx.doi.org/10.20344/amp.4976.

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Meningococcal septic arthritis, ocurring without signs of sepsis, is rare, including at pediatric age. The confinement of infection to a single articulation (monoarticular form) is even rarer in infections by Neisseria spp. We discuss the case of a two month-old caucasian girl, presenting with fever and persistent crying during nappy change. Absence of clinical sepsis was notable. She had had no previous anti-meningococcal immunizations. The ultrasound of the left hip revealed the presence of intra-articular fluid. Culture of the purulent<br />sample after drainage by arthrotomy produced Neisseria meningitidis. She had a good clinical response to the antibiotics. Follow-up showed no sequels. Albeit a rare entity, primary meningococcal arthritis is a mandatory differential diagnosis concerning a feverish child with articular complaints.<br /><strong>Keywords:</strong> Arthritis, Infectious; Infant; Meningococcal Infections; Neisseria meningitidis.

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5

Catalan, F., J. M. Bohbot, P. Sednaoui, and J. Y. Riou. "Infections génitales à Neisseria meningitidis." Médecine et Maladies Infectieuses 21, no. 3 (March 1991): 212–15. http://dx.doi.org/10.1016/s0399-077x(05)80040-x.

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6

MORAN, JOHN S. "Treating Uncomplicated Neisseria gonorrhoeae Infections." Sexually Transmitted Diseases 22, no. 1 (January 1995): 39–47. http://dx.doi.org/10.1097/00007435-199501000-00007.

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7

Valejo Coelho, Margarida Moura, Eugénia Matos-Pires, Vasco Serrão, Ana Rodrigues, and Cândida Fernandes. "Extragenital Gonorrhoea in Men Who Have Sex with Men: A Retrospective Study in a STI Clinic in Lisbon, Portugal." Acta Médica Portuguesa 31, no. 5 (May 30, 2018): 247. http://dx.doi.org/10.20344/amp.10146.

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Introduction: Recent studies worldwide reveal a significant prevalence of extragenital infections by Neisseria gonorrhoeae among men who have sex with men. We aimed to analyse the frequency and characteristics of extragenital gonococcal infections diagnosed in men who have sex with men in a walk-in Sexually Transmitted Infection clinic in Lisbon, Portugal.Material and Methods: We conducted a cross-sectional, retrospective study of the anorectal and/or oropharyngeal Neisseria gonorrhoeae infections in men who have sex with men, diagnosed in our Sexually Transmitted Infection clinic between January 2014 and December 2016.Results: We found extragenital infection in 87 cases of gonorrhoea identified in men who have sex with men in this period, including: 49 cases of anorectal disease, 9 of oropharyngeal disease, 13 cases of infection at both extragenital sites, and 16 of simultaneous extragenital and urogenital gonorrhoea. Patients’ ages ranged from 17 to 64 years (median: 28 years). Forty-seven (54%) of the patients did not present with any extragenital symptoms. Thirty (35%) were human immunodeficiency virus-1-positive.Discussion: Since most extragenital Neisseria gonorrhoeae infections are asymptomatic, they may be missed and go untreated unless actively investigated. Current international guidelines recommend the screening of gonorrhoea at extragenital sites in men who have sex with men because anorectal and oropharyngeal infections constitute a potential disease reservoir, and may facilitate transmission and/or acquisition of human immunodeficiency virus infection.Conclusion: Our results highlight the relevance of testing men who have sex with men for Neisseria gonorrhoeae at extragenital sites, regardless of the existence of local complaints. The implementation of adequate screening programmes in Portugal should be considered. We also reinforce the need to raise awareness in the population regarding the adoption of prophylactic measures against transmission of sexually transmitted infections during anal and/or oral sexual exposure.

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8

Tinoco, I., A. Jarrell, L. Correa, J. Bissler, J. DeVincenzo, Ivan Tinoco, Amber Jarrell, Lauren Correa, John J. Bissler, and John P. DeVincenzo. "#92: What Is the Optimal Management of Patients Immunosuppressed with the Anti-compliment Monoclonal Antibody, Eculizumab? A Case Report and Review." Journal of the Pediatric Infectious Diseases Society 10, Supplement_1 (March 1, 2021): S12. http://dx.doi.org/10.1093/jpids/piaa170.034.

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Abstract Background Patients with deficiencies of terminal components of complement are at hundreds to thousands fold increased risk of severe and fatal Neisseria spp. infections compared with the general population. Eculizumab is a newly approved monoclonal antibody C5 complement inhibitor. It is indicated for the treatment of atypical hemolytic uremic syndrome (atypical HUS), myasthenia gravis, and paroxysmal nocturnal hemoglobinuria. Because of the complement-depleting effect of Eculizumab dosing (Soliris®, Alexion Pharmaceuticals, Munich, Germany), patients are immunosuppressed for specific infectious pathogens (including Neisseria species) against which protection partially relies on normal complement activity. Because Eculizumab treatment is associated with a dramatically increased risk of Neisseria species. infections, recommendations for Neisseria meningitidis vaccination and antibiotic prophylaxis are contained in Eculizumab prescribing information. However, the most appropriate prevention of infections after Eculizumab has yet to be determined. Methods Case report and literature review. Results A previously healthy 7-year-old male was diagnosed with atypical HUS which included renal failure progressing to dialysis, persistent thrombocytopenia, hemolytic anemia, and hemoglobinuria. Stool cultures and a stool multiplex PCR panel did not detect Shiga-like producing E. coli nor E. coli O157/H7. Eculizumab dosing was therefore planned and Infectious Diseases consultation was obtained for appropriate preventions. The FDA Prescribing Information recommends Neisseria meningitidis vaccination before starting Eculizumab or, if immediate Eculizumab is necessary, to use antibiotic prophylaxis until 2 weeks after vaccination. The accepted protective titer after meningococcal vaccination is population based and uses the serum bactericidal assay (SBA). An antibody titer of >1:4 (human compliment) or 1:8 (rabbit complement) is considered protective. However, this “gold standard” assay incorporates the use of exogenous human or rabbit complement. The protective SBA titers in subjects with terminal complement component deficiencies may not be properly assessed using these same SBA titer protective thresholds. Furthermore, serious meningococcal infections have occurred after appropriate vaccination in patients receiving chronic Eculizumab treatments (ie for paroxysmal nocturnal hemoglobinuria). Finally, SBA protective levels after single Neisseria meningitidis vaccination have not been achieved in majorities of patients with renal failure receiving dialysis and or transplant immunosuppression. Conclusions The current Eculizumab prescribing information recommendations for vaccination and antimicrobial prophylaxis may be inadequate to prevent serious Neisseria infections. Repeated Neisseria meningitidis vaccination and extended antibiotic prophylaxis may afford better protection in patients chronically dosed with Eculizumab.

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9

Alonso, J. M., and M. Taha. "Actualité des infections à Neisseria meningitidis." Revue Française des Laboratoires 2002, no. 344 (June 2002): 14. http://dx.doi.org/10.1016/s0338-9898(02)80011-7.

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10

Thangkhiew, I., S. M. Drake, M. Walzman, and A. A. Wade. "Genital infections due to Neisseria meningitidis." Sexually Transmitted Infections 66, no. 4 (August 1, 1990): 305–6. http://dx.doi.org/10.1136/sti.66.4.305-b.

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11

Klausner, Jeffrey D., and Peter Kerndt. "Cephalosporin Resistance in Neisseria gonorrhoeae Infections." JAMA 309, no. 19 (May 15, 2013): 1989. http://dx.doi.org/10.1001/jama.2013.4078.

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12

Queirós, Catarina Soares, and João Borges da Costa. "Gonorrhea: Antimicrobial Resistance and New Drugs." Journal of the Portuguese Society of Dermatology and Venereology 77, no. 3 (October 10, 2019): 233–38. http://dx.doi.org/10.29021/spdv.77.3.1089.

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The global burden of sexually transmitted infections remains high, with significant associated morbidity and mortality. Gonorrhea is the second most notified sexually transmitted infection in Europe, and its incidence has been increasing in the last years. Although traditionally considered a treatable infection, antimicrobial resistance of Neisseria gonorrhoeaeincludes at present also macrolides, tetracyclines, sulfonamides and trimethoprim combinations, quinolones, and even cephalosporins. These high levels of gonococcal resistance to antimicrobials resulting in untreatable infections in the future may become one of the greatest challenges to the prevention and control of sexually transmitted infections, which may be a significant major public health issue. Therefore, the development of novel antimicrobials and/or new dual antimicrobial therapy regimens is urgently needed. In this paper, evolution of antimicrobial resistance of Neisseria gonorrhoeae is reviewed, along with new drugs currently under development for the treatment of this infection.

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13

Huengsberg, M., D. Mullis, J. Gray, R. S. Sawers, and K. W. Radcliffe. "Liaison between gynaecologists, microbiologists and genitourinary medicine clinics in the management of patients with genital chlamydia and gonococcal infections." International Journal of STD & AIDS 9, no. 3 (March 1, 1998): 162–63. http://dx.doi.org/10.1258/0956462981921936.

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Inadequate treatment and follow-up of women with genital infection with Chlamydia trachomatis and Neisseria gonorrhoeae can cause long-term morbidity1,2. Inadequate contact tracing can predispose to re-infection3. As some women with genital infections present to agencies other than genitourinary medicine (GUM) clinics, improved liaison between these and GUM departments are important in safeguarding proper follow-up and contact tracing4.

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Meda, N., S. Ledru, M. Fofana, S. Lankoandé, G. Soula, A. J. Bazié, and J. P. Chiron. "Sexually Transmitted Diseases and Human Immunodeficiency Virus Infection among Women with Genital Infections in Burkina Faso." International Journal of STD & AIDS 6, no. 4 (July 1995): 273–77. http://dx.doi.org/10.1177/095646249500600410.

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Summary: This study reports the prevalence of sexually transmitted diseases (STDs) among gynaecological outpatients presenting at the Bobo-Dioulasso Hospital (Burkina Faso) with genital infections and examines the factors associated with HIV infection in this population. Of 245 eligible non-pregnant women, 220 consented to participate in the study. Seventy-seven per cent had sexually transmitted infections. The most common were: Trichomonas vaginalis (28%), Chlamydia trachomatis (27%), bacterial vaginosis (20%), Candida albicans (17%), Neisseria gonorrhoeae (11%). The prevalence of HIV infection was 42% (95% ci. 35.3, 48.3). Logistic regression analyses revealed Neisseria gonorrhoeae to be the only STD significantly associated with infection with HIV ( P = 0.04). A sedimentation rate greater than or equal to 100 mm in the first hour was also associated with HIV infection ( P < 0.001). Women consulting for genital infections constitute a high risk group for HIV infection and other STDs. Management of these women should focus on the early diagnosis and treatment of STDs.

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Grad, Alecsandra Iulia, Mihaela Laura Vica, Horea Vladi Matei, Doru Lucian Grad, Ioan Coman, and Dumitru Alexandru Tataru. "POLYMERASE CHAIN REACTION AS A DIAGNOSTIC TOOL FOR SIX SEXUALLY TRANSMITTED INFECTIONS - PRELIMINARY RESULTS." Medicine and Pharmacy Reports 88, no. 1 (January 28, 2015): 33–37. http://dx.doi.org/10.15386/cjmed-373.

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Background and aim. Sexually transmitted infections are a very frequent and under-diagnosed cause of illness worldwide. A high number of detection methods and a large range of specimens in which sexually transmitted infections can be determined are available at the moment. Polymerase chain reaction performed on first void urine offers the advantage of being non-invasive, self-collectable and has high sensitivity and specificity. We looked to determine the frequency of Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Mycoplasma hominis, Mycoplasma genitalium and Ureaplasma urealyticum in symptomatic and asymptomatic patients.Methods. Six sexually transmitted infections were determined in the first void urine of 15 symptomatic and asymptomatic patients by polymerase chain reaction. We used “Epicenter MasterPure™ Complete DNA and RNA Purification Kit” for the DNA purification and “Seeplex® STD6 ACE Detection” for the DNA amplification. The results were examined in UV light.Results. A number of 5 patients had positive results for Chlamydia trachomatis or Neisseria gonorrhoeae. Sexually transmitted infections are more frequent in men between 27 and 40 years old.Conclusions. Polymerase chain reaction is a good diagnostic tool for sexually transmitted infections because it has a high sensitivity and specificity. Chlamydia trachomatis is the most frequent sexually transmitted infection, followed by Neisseria gonorrhoeae.

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Isa Adamu, Ibrahim, and Sulaiman Usman. "Mathematical Model for the Dynamics of Neisseria Gonorrhea Disease with Natural Immunity and Treatment Effects." Journal of Mathematics Research 10, no. 2 (March 29, 2018): 151. http://dx.doi.org/10.5539/jmr.v10n2p151.

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Neisseria gonorrhea infection; a sexually transmitted disease, is caused primarily by a type of germ; a bacteria called neisseria gonorrhea. The infection is a major public health challenge today due to the high incidence of infections accompanied by a dwindling number of treatment options especially in developing and underdeveloped countries. In this paper, we developed a mathematical model for the transmission dynamics of neisseria gonorrhea infection and studied the effect of natural immunity and treatment as the only available control interventions on the spread of the disease in a population. We computed the model disease-free equilibrium and analyzed its local and global stability in a well-defined positively invariant and attracting set Ω using the next-generation matrix plus linearization method and the comparison theorem respectively. The disease-free equilibrium was proved to be both locally and globally asymptotically stable if $R_0<1$ and unstable if $R_0>1$. We conducted sensitivity analysis of parameters in the basic reproduction number $R_0$ using the normalized forward sensitivity index method. Results of the analysis revealed that $R_0$ decreases with increase in treatment and natural immunity rates. The results of the numerical simulations carried out using MATLAB R2012B showed that there is increase in new infections due to increased contact with infected individuals in the susceptible population and that, with increased treatment rate and controlled death due to the disease in the population, neisseria gonorrhea infection would be wiped out within 300 days of the treatment intervention.

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Mulakoli, Festus. "Chlamydia trachomatis and Neisseria gonorrhoea Co-Infection Among Patients Attending a Teaching Hospital in Nairobi County: A Retrospective Study." East Africa Science 3, no. 1 (March 15, 2021): 51–57. http://dx.doi.org/10.24248/easci-d-20-00008.

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Background: Chlamydia trachomatis and Neisseria gonorrhoea are microbes that have been associated with urethritis in both male and female genders, which often may lead to complicated conditions such as pelvic inflammatory disease (PID) and infertility globally among others health complications. In Kenya and other developing countries, sexually transmitted infections associated with Chlamydia trachomatis and Neisseria gonorrhoea still pose a challenge in public health. Methods: A retrospective study was conducted by reviewing laboratory data from Jan 2018 to Dec 2018 to estimate the prevalence of C trachomatis and N gonorrhoea coinfections in patients attending a tertiary institution and its satellite clinics spread across the country. A total of 1228 patient’s data aged 3-69 years was reviewed; with age, gender and Chlamydia trachomatis and Neisseria gonorrhoea status being analyzed. Results: A total of 1228 patients who visited the hospital in 2018 had their urine samples being tested for Chlamydia trachomatis and Neisseria gonorrhoea by use of a PCR technique. Majority of the patients were males (63.7%). The patients who tested for Chlamydia trachomatis and Neisseria gonorrhoea had an average age of 34 years (range: 3–69 years). Of those 1.4% tested positive for both Chlamydia trachomatis and Neisseria gonorrhoea infections, and males were more infected than females (1.1% vs 0.3). From the information gathered during the study period, the proportion of patients with Chlamydia trachomatis infection was (16.1 %) (95 % CI 9.5, 17.9), and with N. gonorrhoea infection was 5.4%. Coinfection was highest among sexually active group that is those aged between 21 years to 40 years. Conclusion: The prevalence of C. trachomatis is significantly high among male patients. We recommend the implement a molecular screening for Chlamydia trachomatis and Neisseria gonorrhoea to identifying asymptomatic female cases. This study further provides evidence on the importance of contact tracing in the management of Chlamydia trachomatis and other STIs. There is an urgent need for studies designed to investigate the prevalence and risk factors of Chlamydia trachomatis and Neisseria gonorrhoea among female patients who are majorly asymptomatic in Kenya.

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Crew, Page E., Winston E. Abara, Lynda McCulley, Peter E. Waldron, Robert D. Kirkcaldy, Emily J. Weston, Kyle T. Bernstein, S. Christopher Jones, and Susan J. Bersoff-Matcha. "Disseminated Gonococcal Infections in Patients Receiving Eculizumab: A Case Series." Clinical Infectious Diseases 69, no. 4 (November 12, 2018): 596–600. http://dx.doi.org/10.1093/cid/ciy958.

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Abstract Background Gonorrhea is the second most commonly reported notifiable condition in the United States. Infrequently, Neisseria gonorrhoeae can cause disseminated gonococcal infection (DGI). Eculizumab, a monoclonal antibody, inhibits terminal complement activation, which impairs the ability of the immune system to respond effectively to Neisseria infections. This series describes cases of N. gonorrhoeae infection among patients receiving eculizumab. Methods Pre- and postmarketing safety reports of N. gonorrhoeae infection in patients receiving eculizumab worldwide were obtained from US Food and Drug Administration safety databases and the medical literature, including reports from the start of pivotal clinical trials in 2004 through 31 December 2017. Included patients had at least 1 eculizumab dose within the 3 months prior to N. gonorrhoeae infection. Results Nine cases of N. gonorrhoeae infection were identified; 8 were classified as disseminated (89%). Of the disseminated cases, 8 patients required hospitalization, 7 had positive blood cultures, and 2 required vasopressor support. One patient required mechanical ventilation. Neisseria gonorrhoeae may have contributed to complications prior to death in 1 patient; however, the fatality was attributed to underlying disease per the reporter. Conclusions Patients receiving eculizumab may be at higher risk for DGI than the general population. Prescribers are encouraged to educate patients receiving eculizumab on their risk for serious gonococcal infections and perform screening for sexually transmitted diseases (STDs) per the Centers for Disease Control and Prevention STD treatment guidelines or in suspected cases. If antimicrobial prophylaxis is used during eculizumab therapy, prescribers should consider trends in gonococcal antimicrobial susceptibility due to emerging resistance concerns.

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Emonts, M., JA Hazelzet, R. de Groot, and PWM Hermans. "Host genetic determinants of Neisseria meningitidis infections." Lancet Infectious Diseases 3, no. 9 (September 2003): 565–77. http://dx.doi.org/10.1016/s1473-3099(03)00740-0.

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Mahon, Barbara E., Marc B. Rosenman, Marilyn F. Graham, and J. Dennis Fortenberry. "Postpartum Chlamydia trachomatis and Neisseria gonorrhoeae infections." American Journal of Obstetrics and Gynecology 186, no. 6 (June 2002): 1320–25. http://dx.doi.org/10.1067/mob.2002.122405.

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21

Sesnan, Kevin, Bernadette Gillespie, and Martin Blooms. "Penicillinase‐producing Neisseria gonorrhoeae infections in Perth." Medical Journal of Australia 160, no. 9 (May 1994): 586. http://dx.doi.org/10.5694/j.1326-5377.1994.tb138368.x.

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Kirkcaldy, Robert D., Gail A. Bolan, and Judith N. Wasserheit. "Cephalosporin Resistance in Neisseria gonorrhoeae Infections—Reply." JAMA 309, no. 19 (May 15, 2013): 1989. http://dx.doi.org/10.1001/jama.2013.4084.

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Allen, Vanessa G., Roberto G. Melano, and Donald E. Low. "Cephalosporin Resistance in Neisseria gonorrhoeae Infections—Reply." JAMA 309, no. 19 (May 15, 2013): 1989. http://dx.doi.org/10.1001/jama.2013.4087.

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CHRISTENSEN, J. J., O. GADEBERG, and B. BRUUN. "Neisseria meningitidis:Occurrence in non-pneumonic pulmonary infections." APMIS 96, no. 1-6 (January 1988): 218–22. http://dx.doi.org/10.1111/j.1699-0463.1988.tb05294.x.

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Stern, Marc F., Gary E. Rosenthal, and C. Seth Landefeld. "Diagnosing chlamydia trachomatis and neisseria gonorrhoeae infections." Journal of General Internal Medicine 6, no. 2 (March 1991): 183. http://dx.doi.org/10.1007/bf02598326.

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Hughes, G., and K. A. Fenton. "Recent trends in gonorrhoea – an emerging public health issue ?" Eurosurveillance 5, no. 1 (January 1, 2000): 1–2. http://dx.doi.org/10.2807/esm.05.01.00012-en.

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Neisseria gonorrhoeae infection remains one of the commonest bacterial sexually transmitted infections (STIs) in many developed countries. Its disproportionate burden on deprived, inner city populations and association with infertility have made its contr

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Nemes-Nikodém, Éva, Alexandra Brunner, Béla Tóth, Veronika Tóth, András Bánvölgyi, and Eszter Ostorházi. "Antimicrobal resistance ofNeisseria gonorrhoeaestrains in Hungary." Orvosi Hetilap 156, no. 6 (February 2015): 226–29. http://dx.doi.org/10.1556/oh.2015.30079.

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Introduction: European guidelines on the treatment of Neisseria gonorrhoeae are based mostly on Western European data, although these recommendations may not be optimised for the circumstances in Hungary. Aim: The aim of the authors was to assess current antimicrobial resistance of Neisseria gonorrhoeae strains in order to enhance gonococcal antimicrobial surveillance in Hungary. Neisseria gonorrhoeae strains were isolated at the National Center of Sexually Transmitted Infections at the Department of Dermatology, Venerology and Dermatooncology of Semmelweis University in the period between January 2011 and June 2014. Method: Antimicrobial resistance was determined with minimum inhibitory concentration measurement. Neisseria gonorrhoeae Multiantigen Sequence typing was used as molecular typing method. Results: Resistance to the currently recommended extended spectrum cephalosporins is rare in Hungary, but there is an emerging azithromycin resistance among the Neisseria gonorrhoeae strains. Conclusions: Revision of the national treatment guideline must consider that the most frequent sequence types of Neisseria gonorrhoeae strains causing infections in Hungary are mainly resistant to azithromycin. Orv. Hetil., 2015, 156(6), 226–229.

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Humbert, Maria Victoria, and Myron Christodoulides. "Atypical, Yet Not Infrequent, Infections with Neisseria Species." Pathogens 9, no. 1 (December 20, 2019): 10. http://dx.doi.org/10.3390/pathogens9010010.

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Neisseria species are extremely well-adapted to their mammalian hosts and they display unique phenotypes that account for their ability to thrive within niche-specific conditions. The closely related species N. gonorrhoeae and N. meningitidis are the only two species of the genus recognized as strict human pathogens, causing the sexually transmitted disease gonorrhea and meningitis and sepsis, respectively. Gonococci colonize the mucosal epithelium of the male urethra and female endo/ectocervix, whereas meningococci colonize the mucosal epithelium of the human nasopharynx. The pathophysiological host responses to gonococcal and meningococcal infection are distinct. However, medical evidence dating back to the early 1900s demonstrates that these two species can cross-colonize anatomical niches, with patients often presenting with clinically-indistinguishable infections. The remaining Neisseria species are not commonly associated with disease and are considered as commensals within the normal microbiota of the human and animal nasopharynx. Nonetheless, clinical case reports suggest that they can behave as opportunistic pathogens. In this review, we describe the diversity of the genus Neisseria in the clinical context and raise the attention of microbiologists and clinicians for more cautious approaches in the diagnosis and treatment of the many pathologies these species may cause.

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Low, Sharon Y. Y., Catherine W. M. Ong, Po-Ren Hsueh, Paul Ananth Tambyah, and Tseng Tsai Yeo. "Neisseria gonorrhoeae paravertebral abscess." Journal of Neurosurgery: Spine 17, no. 1 (July 2012): 93–97. http://dx.doi.org/10.3171/2012.4.spine11914.

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The authors present the case of an isolated gonococcal paravertebral abscess with an epidural component in a 42-year-old man. A primary epidural abscess of the spine is a rare condition and is most commonly caused by Staphylococcus aureus. In this report, the authors present their therapeutic decisions and review the relevant literature on disseminated gonococcal infection in a patient presenting with an epidural abscess. A 42-year-old Indonesian man was admitted with symptoms of neck and upper back pain and bilateral lower-limb weakness. Clinical examination was unremarkable apart from tenderness over the lower cervical spine. Postgadolinium T1-weighted MRI of the cervical and thoracic spine demonstrated an enhancing lesion in the right paraspinal and epidural soft tissue at C-6 to T1–2, in keeping with a spinal epidural abscess. The patient underwent laminectomy of C-7 and T-1 with abscess drainage. Tissue cultures subsequently grew Neisseria gonorrhoeae that was resistant to quinolones by genotyping. Upon further questioning, the patient admitted to unprotected sexual intercourse with commercial sex workers. Further investigations showed that he was negative for other sexually transmitted infections. Postoperatively, he received a course of beta-lactam antibiotics with good recovery. Clinicians should be aware of this unusual disseminated gonococcal infection manifested in any patient with the relevant risk factors.

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Bhatta, DR, S. Gokhale, MT Ansari, HK Tiwari, A. Gaur, JP Mathuria, and AN Ghosh. "Gonococcal infections: The trends of antimicrobial susceptibility of Neisseria gonorrhoeae in Western Nepal." Nepal Journal of Medical Sciences 1, no. 2 (August 2, 2012): 74–78. http://dx.doi.org/10.3126/njms.v1i2.6603.

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Background: Gonorrhea is caused by Neisseria gonorrhoeae, is an important public health problem and is the second most common reportable sexually transmitted bacterial infection. Present study was conducted to determine the antimicrobial resistance pattern of Neisseria gonorrhoeae isolates from various clinical specimens. Methods: This is a hospital based retrospective study conducted at Manipal Teaching Hospital, Pokhara, Nepal. Various clinical specimens (urethral, cervical and conjunctival discharges) were collected from the suspected cases of gonococcal infections between January 2004 to December 2010. Specimens were subjected to Gram stain and culture on chocolate agar. Antibiotic susceptibility testing was performed on chocolate agar by Kirby Bauer’s disc diffusion method. Results: A total of 119 patients were tested for gonococcal infections. Forty-eight patients were diagnosed as having gonococcal infections, of which 40 cases were culture positive. Penicillin resistance was seen in 27 (67%) cases while all isolates were sensitive to ceftriaxone. Conclusion: Neisseria gonorrhoeae isolates are becoming increasingly resistant to antibiotics like penicillin, ciprofloxacin and tetracycline. Therefore, continuous surveillance of antibiotic resistance pattern is required in order to start empirical antibiotic therapy in high risk population like commercial sex workers. DOI: http://dx.doi.org/10.3126/njms.v1i2.6603 Nepal Journal of Medical Sciences. 2012;1(2): 74-78

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Katyal, Nakul, Latika Nirola, Naureen Narula, and Raghav Govindarajan. "Diffuse Gonococcal Infection (DGI) in a Patient with Treatment-Refractory Acetylcholine Receptor Antibody-Positive (AChR+) Generalized Myasthenia Gravis (gMG) Treated with Eculizumab." Case Reports in Neurological Medicine 2021 (June 14, 2021): 1–3. http://dx.doi.org/10.1155/2021/9713413.

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Patients receiving complement inhibitor, eculizumab, are at high risk for infections with encapsulated organisms such as Neisseria due to impaired opsonophagocytic activity. Impaired complement immunity may increase the risk for dissemination of asymptomatic Neisseria gonorrhoeae. Disseminated Gonococcal Infection (DGI) is a rare but potentially life-threatening complication associated with eculizumab. Physicians should obtain adequate sexual histories from the patients and educate them on safe sexual practices. Here, we describe a case of DGI in a 32-year-old African American female patient with acetylcholine receptor antibody-positive (AChR+) generalized myasthenia gravis (gMG), receiving eculizumab.

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Farraj, Mohammad A., Gabi M. Abusada, Abed Alraoof M. Saleem, Ayyub Y. Joaidi, Raba M. Radad, Hiba N. Atrash, Israr N. Sabri, and Tamer A. Essawi. "Detection of Neisseria gonorrhoeae in Palestinian women using polymerase chain reaction." Asian Biomedicine 4, no. 4 (August 1, 2010): 637–40. http://dx.doi.org/10.2478/abm-2010-0081.

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Abstract Background: Neisseria gonorrohoeae is an exclusive human pathogen that primarily infects the urogenital epithelia. Infections caused by N. gonorrhoeae are considered the second major cause of sexually transmitted disease after Chlamydiae worldwide. Although the urethra and the uterine cervix serve as the initial sites for gonococcal infections in men and women, infection of the conjunctiva, pharynx, tendons, joints, as well as rectal mucosa are also reported. Objectives: The objectives of this study were to introduce molecular techniques such as polymerase chain reaction (PCR) to detect N. gonorrhoeae directly from endocervical swabs. In addition, it provides a picture of Neisseria gonorrohea infection among a sample of Palestinian women in West Bank. Methods: Two hundred and thirteen endocervical swabs were collected from sexually active married women with endocervical abnormalities attending healthcare clinics. DNA was extracted directly from the swabs and PCR was performed using specific primers targeting the orf1 region of the genome. Results: The results obtained indicated that the percentage of positive cases of N. gonorrhoeae among the women tested was 1.40%. Conclusion: Implementing guidelines for comprehensive screening of men and women with more sensitive tests may improve detection and management of sexually transmitted infections.

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CHAISILWATTANA, PONGSAKDI, and NEWTON G. OSBORNE. "Antibiotic Treatment of Neisseria gonorrhoeae Infections in Women." Journal of Gynecologic Surgery 10, no. 1 (January 1994): 55–56. http://dx.doi.org/10.1089/gyn.1994.10.55.

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Gupta, Ruchi, Fatma Levent, C. Mary Healy, and Morven S. Edwards. "Unusual Soft Tissue Manifestations of Neisseria Meningitidis Infections." Clinical Pediatrics 47, no. 4 (May 2008): 400–403. http://dx.doi.org/10.1177/0009922807310248.

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Rice, Roselyn J. "Treatment of Uncomplicated Infections due to Neisseria gonorrhoeae." JAMA 255, no. 13 (April 4, 1986): 1739. http://dx.doi.org/10.1001/jama.1986.03370130095031.

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del Castillo, C. M., J. A. Vázquez, J. Romero, and A. Pascual. "Infections by Neisseria meningitidis serogroup X in Spain." Clinical Microbiology and Infection 9, no. 9 (September 2003): 964–65. http://dx.doi.org/10.1046/j.1469-0691.2003.00685.x.

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Han, X. Y., T. Hong, and E. Falsen. "Neisseria bacilliformis sp. nov. Isolated from Human Infections." Journal of Clinical Microbiology 44, no. 2 (February 1, 2006): 474–79. http://dx.doi.org/10.1128/jcm.44.2.474-479.2006.

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Nassif, X., and M. So. "Interaction of pathogenic neisseriae with nonphagocytic cells." Clinical Microbiology Reviews 8, no. 3 (July 1995): 376–88. http://dx.doi.org/10.1128/cmr.8.3.376.

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The ability to interact with nonphagocytic cells is a crucial virulence attribute of the meningococcus and the genococcus. Like most bacterial pathogens, Neisseria meningitidis and Neisseria gonorrhoeae initiate infections by colonizing the mucosal epithelium, which serves as the site of entry. After this step, both bacteria cross the intact mucosal barrier. While N. gonorrhoeae is likely to remain in the subepithelial matrix, where it initiates an intense inflammatory reaction, N. meningitidis enters the bloodstream, and eventually the cerebrospinal fluid to cause meningitis. Both pathogens have evolved very similar mechanisms for interacting with host cells. Surface structures that influence bacterium-host interactions include pili, the meningococcal class 5 outer membrane proteins or the gonococcal opacity proteins, lipooligosaccharide, and the meningococcal capsule. This review examines what is known about the roles these structures play in bacterial adhesion and invasion, with special emphasis, on pilus-mediated adhesion. Finally, the importance of these structures in neisserial pathogenesis is discussed.

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’diah, Halimatussa, Urip Urip, and Yunan Jiwintarum. "Variasi Suhu Terhadap Pertumbuhan Neisseria Gonorrhoeae pada Media Coklat Agar Plate." Quality : Jurnal Kesehatan 11, no. 2 (November 1, 2018): 74–77. http://dx.doi.org/10.36082/qjk.v11i2.71.

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ABSTRACT Sexually transmitted infections (STI) are infections whose transmission is mainly through sexual intercourse. Gonorrhoeae is a disease that has a high incidence among sexually transmitted infections (STDs). The purpose of this study was to determine the effect of temperature variations on the growth of Neisseria gonorrhoeae. This study was pre-experimental with 6 treatments and 4 replications, namely heating water with direct inoculation to the media, without heating, temperature 40˚C, 50˚C, 60˚C, and 70˚C. It was examined by obtaining the results that from each treatment there was no colony growth on the Chocolate Agar Plate media. Those who experienced growth were only treated with direct inoculation on the media so that it could be concluded that there was no effect on the variation of water heating temperature on the growth of Neisseria gonorrhoeae on CAP media. Keywords : Neisseria gonorrhoeae, Growth, Temperature

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Wijers, Juliën, Christian Hoebe, Nicole Dukers-Muijrers, Petra Wolffs, and Geneviève van Liere. "The Characteristics of Patients Frequently Tested and Repeatedly Infected with Neisseria gonorrhoeae." International Journal of Environmental Research and Public Health 17, no. 5 (February 26, 2020): 1495. http://dx.doi.org/10.3390/ijerph17051495.

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We assessed whether patients repeatedly infected with Neisseria gonorrhoeae (NG) were different compared to patients repeatedly tested negative, to obtain insight into the characteristics of patients frequently tested and infected with NG. All patients tested for NG (n = 16,662) between January 2011 and July 2018 were included. Multivariable logistic regression analyses were performed for the outcomes “repeat NG infections” and “once NG positive and not retested” versus patients “repeatedly tested NG negative”. Of the individuals tested for NG, 0.2% (40/16,662) had repeat (≥2) NG infections, and accounted for 23% of all diagnosed NG infections. STI clinic patients, men (mostly men who have sex with men (MSM)), patients aged ≥25 years, and patients co-infected with HIV or Chlamydia trachomatis (CT) more often had repeat NG infections. The number of patients not retested after their initial NG diagnosis was 29.9% (92/308). Men (mostly MSM), HIV positive patients, and patients notified for sexually transmitted infections (STIs) were more often NG positive and not retested. Concluding, only 40 patients tested for NG accounted for one in four diagnosed NG infections. However, re-infections are likely to be missed among MSM and HIV positive patients, as they were mainly not retested after NG infection. It remains important to test and re-test for NG, especially in MSM, in order to halt transmission.

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Bicoll, Paige S., Ashima Goyal, Neal B. Blatt, and Bishara J. Freij. "Eculizumab-Associated Moraxella lacunata Bacteremia and Systemic Inflammatory Response Syndrome in a Toddler with Atypical Hemolytic Uremic Syndrome." Clinical Medicine Insights: Pediatrics 15 (January 2021): 117955652199236. http://dx.doi.org/10.1177/1179556521992367.

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Moraxella lacunata, a low-virulence Gram-negative coccobacillus, is classically associated with conjunctivitis and upper respiratory tract infections; systemic infections such as sepsis have rarely been reported, especially in children. We describe a 28-month-old girl with atypical hemolytic uremic syndrome and stage II chronic kidney disease on long-term eculizumab therapy who presented with systemic inflammatory response syndrome and was found to have Moraxella lacunata bloodstream infection. Eculizumab, a humanized monoclonal anti-C5 antibody, has been associated with susceptibility to infections with encapsulated bacteria, especially Neisseria meningitidis. This is the first report of an invasive bacterial infection with Moraxella lacunata in a pediatric eculizumab recipient.

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Cater, Kathryn, Ryszard Międzybrodzki, Vera Morozova, Sławomir Letkiewicz, Marzanna Łusiak-Szelachowska, Justyna Rękas, Beata Weber-Dąbrowska, and Andrzej Górski. "Potential for Phages in the Treatment of Bacterial Sexually Transmitted Infections." Antibiotics 10, no. 9 (August 24, 2021): 1030. http://dx.doi.org/10.3390/antibiotics10091030.

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Bacterial sexually transmitted infections (BSTIs) are becoming increasingly significant with the approach of a post-antibiotic era. While treatment options dwindle, the transmission of many notable BSTIs, including Neisseria gonorrhoeae, Chlamydia trachomatis, and Treponema pallidum, continues to increase. Bacteriophage therapy has been utilized in Poland, Russia and Georgia in the treatment of bacterial illnesses, but not in the treatment of bacterial sexually transmitted infections. With the ever-increasing likelihood of antibiotic resistance prevailing and the continuous transmission of BSTIs, alternative treatments must be explored. This paper discusses the potentiality and practicality of phage therapy to treat BSTIs, including Neisseria gonorrhoeae, Chlamydia trachomatis, Treponema pallidum, Streptococcus agalactiae, Haemophilus ducreyi, Calymmatobacterium granulomatis, Mycoplasma genitalium, Ureaplasma parvum, Ureaplasma urealyticum, Shigella flexneri and Shigella sonnei. The challenges associated with the potential for phage in treatments vary for each bacterial sexually transmitted infection. Phage availability, bacterial structure and bacterial growth may impact the potential success of future phage treatments. Additional research is needed before BSTIs can be successfully clinically treated with phage therapy or phage-derived enzymes.

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Vrielink, Alice, Anandhi Anandan, Susannah Piek, Isabel Moares, and Charlene Kahler. "Structure of an endotoxin modifying enzyme and virulence factor in Neisseria." Acta Crystallographica Section A Foundations and Advances 70, a1 (August 5, 2014): C1047. http://dx.doi.org/10.1107/s2053273314089529.

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Multiple drug resistance (MDR) in Gram-negative bacteria represents one of the most intractable problems facing modern medicine. Not only is antibiotic resistance incrementally increasing during clinical treatment of infections, but also the evolution and acquisition of new mechanisms of antibiotic resistance lead to the sudden loss of the capacity to treat infections. The most recent superbug, MDR-Neisseria gonorrhoeae, causes the untreatable sexually transmitted infection gonorrhoeae. Chronic gonococcal infections have a high morbidity rate and, due to the explosion in cases worldwide, the community burden is enormous. N. gonorrhoeae colonizes the mucosal surfaces of the human body and has a number of virulence mechanisms that prevent clearance by the human immune system. The most important of these mechanisms is decoration of the lipooligosaccharide lipid A headgroups with phosphoethanolamine (PEA) by the enzyme, lipid A PEA transferase (LptA). Inactivation of the LptA results in the complete loss of PEA groups from lipid A, loss of bacterial colonisation of epithelial cells (Takahashi et al., 2008), increased sensitivity to cationic antimicrobial peptides (Tzeng et al., 2005) and reduced resistance to human complement mediated killing (Lewis et al., 2013). LptA knockouts of N. gonorrhoeae also result in the complete loss of virulence in models of human and mouse infections. Based on these findings we have undertaken a structure-guided approach to develop inhibitors of LptA that will assist in controlling infection and transmission by this important human pathogen. LptA is a membrane protein that interacts with two different lipid substrates. We have determined the crystal structure of the enzyme to 2.75Å resolution. The structure provides insights into the mechanism of substrate binding and catalysis and suggests that significant conformational changes occur through its catalytic cycle.

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Barbee, Lindley A., and Matthew R. Golden. "Aztreonam for Neisseria gonorrhoeae: a systematic review and meta-analysis." Journal of Antimicrobial Chemotherapy 75, no. 7 (April 7, 2020): 1685–88. http://dx.doi.org/10.1093/jac/dkaa108.

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Abstract Background Ceftriaxone is the only consistently active antimicrobial agent recommended for the treatment of Neisseria gonorrhoeae. Although some new antimicrobials are in development, the necessity to expand treatment options in the near term may require using older drugs that have not been widely used to treat gonorrhoea. Methods We conducted a literature review of clinical trials and case series, published from 1983 to 2017, reporting treatment efficacy results following administration of 1 g aztreonam intramuscularly or IV for uncomplicated gonococcal infections. We summed trial data, stratified by anatomical site of infection, and calculated summary efficacy estimates and 95% CI for each site of infection. Results The 10 identified clinical trials enrolled 678, 38 and 16 individuals with urogenital, rectal and pharyngeal gonorrhoea, respectively. Aztreonam had an efficacy of 98.6% (95% CI: 97.5%–99.4%) for urogenital, 94.7% (95% CI: 82.3%–99.4%) for rectal and 81.3% (95% CI: 54.4%–96.0%) for pharyngeal gonococcal infections. Conclusions Although most clinical trials included in this meta-analysis were conducted >30 years ago, aztreonam appears to have excellent efficacy for urogenital gonorrhoea; its efficacy at extragenital sites remains uncertain.

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Makino, Herica, Alessandra Tammy Hayakawa Ito De Sousa, Lucas Avelino Dandolini Pavelegini, Yolanda Paim Arruda Trevisan, Edson Moleta Colodel, Valéria Régia Franco Sousa, Valéria Dutra, and Luciano Nakazato. "Pneumonia in Cats associated with Neisseria sp." Acta Veterinaria 71, no. 2 (June 1, 2021): 211–18. http://dx.doi.org/10.2478/acve-2021-0018.

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Abstract Neisseria sp. is a Gram-negative diplococcus bacterium usually present on the mucosal surfaces of animals without causing an obvious pathology. The objective of this study was to report the isolation of Neisseria sp. from severe cases of pyogranulomatous pneumonia with the formation of a Splendore-Hoeppli structure in two cats treated at a veterinary hospital. This paper suggests that the Neisseria genus members may be involved in lower respiratory tract infections in cats, with the molecular diagnosis being a necessary method for the correct identification of this bacteria in animals.

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Sbiti, Mohammd, Imane Benbella, Rabii Behraoui, and lhoussaïn Louzi. "Neisseria Gonorrhoeae Infections: Biological Diagnosis, Antibiotic Resistance and Treatment." Acta Scientific Microbiology 2, no. 9 (October 15, 2019): 41–50. http://dx.doi.org/10.31080/asmi.2019.02.0397.

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Moulignier, A., D. Binet, P. Lesavre, M. Eliaszewicz, M. C. Meyohas, and J. Frottier. "Deficit en C7 et infections successives a Neisseria spp." Médecine et Maladies Infectieuses 19, no. 10 (October 1989): 454–55. http://dx.doi.org/10.1016/s0399-077x(89)80133-7.

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Chanal, Johan, François Lassau, Philippe Morand, Michel Janier, and Nicolas Dupin. "Actualités diagnostique et thérapeutique des infections à Neisseria gonorrhoeae." La Presse Médicale 42, no. 4 (April 2013): 454–58. http://dx.doi.org/10.1016/j.lpm.2012.09.023.

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Fifer, Helen, and Gwenda Hughes. "Oropharyngeal Neisseria gonorrhoeae infections: should women be routinely tested?" Lancet Infectious Diseases 21, no. 6 (June 2021): 754–56. http://dx.doi.org/10.1016/s1473-3099(20)30777-5.

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Li, Jin, Shenghua Chang, Haiying Guo, Yaoting Ji, Han Jiang, Lianguo Ruan, and Minquan Du. "Altered Salivary Microbiome in the Early Stage of HIV Infections among Young Chinese Men Who Have Sex with Men (MSM)." Pathogens 9, no. 11 (November 19, 2020): 960. http://dx.doi.org/10.3390/pathogens9110960.

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Human immunodeficiency virus (HIV) infections are spiking in Chinese young men who have sex with men (MSM). To explore alterations in the salivary microbiome and its correlation with demographic characteristics, CD4+ T cell count and viral load (VL) in HIV infections, samples of unstimulated whole saliva were analyzed by 16S rRNA gene sequencing using the Illumina MiSeq platform in 20 HIV newly infected patients before the initiation of antiretroviral therapy (ART) and at three and six months after, and in 20 age- and gender-paired healthy Chinese people. The results showed that the alpha diversity of salivary microbiota in HIV infections did not show differences from the healthy controls, but was reduced after six months under ART treatment. Comparative analysis revealed that Streptococcus was enriched in HIV-infected individuals, while Neisseria was enriched in the healthy control group. After effective ART, the salivary microbiota composition was not completely restored, although some microbiota recovered. In addition, we found Provotella_7, Neisseria and Haemophilus were correlated negatively with CD4+ T cell count, while Neisseria was correlated positively with VL. We conclude that HIV infections experience a dysbiosis of the salivary microbiome. The salivary microbiome test could be a substitute for the blood tests in the diagnosis and prognosis of diseases.

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