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Journal articles on the topic 'NEMO-related protein'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Wu, Chuan-Jin. "NEMO Family of Proteins as Polyubiquitin Receptors: Illustrating Non-Degradative Polyubiquitination’s Roles in Health and Disease." Cells 14, no. 4 (2025): 304. https://doi.org/10.3390/cells14040304.

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The IκB kinase (IKK) complex plays a central role in many signaling pathways that activate NF-κB, which turns on a battery of genes important for immune response, inflammation, and cancer development. Ubiquitination is one of the most prevalent post-translational modifications of proteins and is best known for targeting substrates for proteasomal degradation. The investigations of NF-κB signaling pathway primed the unveiling of the non-degradative roles of protein ubiquitination. The NF-κB-essential modulator (NEMO) is the IKK regulatory subunit that is essential for IKK activation by diverse

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Clark, Kristopher, Mark Peggie, Lorna Plater, et al. "Novel cross-talk within the IKK family controls innate immunity." Biochemical Journal 434, no. 1 (2011): 93–104. http://dx.doi.org/10.1042/bj20101701.

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Members of the IKK {IκB [inhibitor of NF-κB (nuclear factor κB)] kinase} family play a central role in innate immunity by inducing NF-κB- and IRF [IFN (interferon) regulatory factor]-dependent gene transcription programmes required for the production of pro-inflammatory cytokines and IFNs. However, the molecular mechanisms that activate these protein kinases and their complement of physiological substrates remain poorly defined. Using MRT67307, a novel inhibitor of IKKϵ/TBK1 (TANK {TRAF [TNF (tumour-necrosis-factor)-receptor-associated factor]-associated NF-κB activator}-binding kinase 1) and

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Tono, Chikako, Yoshihiro Takahashi, Kiminori Terui, et al. "Correction of Immunodeficiency Associated with NEMO Mutation by Umbilical Cord Stem Cell Transplantation Using a Reduced-Intensity Conditioning Regimen." Blood 108, no. 11 (2006): 5392. http://dx.doi.org/10.1182/blood.v108.11.5392.5392.

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Abstract X-linked recessive anhidrotic ectodermal dysplasia with immunodeficiency (XL-EDA-ID) is a developmental and immunologic disorder caused by hypomorphic mutations in the nuclear factor-κB essential modulator (NEMO) gene. NEMO is the regulatory subunit of the IκB kinase (IKK) complex, which phosphorylates and degrades NF-κB inhibitor α (IκBα), causing NF-κB activation. Following the identification of amorphic NEMO mutations causing familial incontinentia pigmenti (IP), hypomorphic mutations in NEMO have been identified in XL-EDA-ID patients. Affected boys are susceptible to infections wi

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Sarry, Morgan, Grégory Caignard, Juliette Dupré, et al. "Host-Specific Interplay between Foot-and-Mouth Disease Virus 3D Polymerase and the Type-I Interferon Pathway." Viruses 15, no. 3 (2023): 666. http://dx.doi.org/10.3390/v15030666.

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Foot-and-mouth disease (FMD) is a highly contagious viral disease affecting cloven-hoofed animals. One of the issues related to this disease is the persistence of its causative agent, foot-and-mouth disease virus (FMDV). While the mechanisms of FMDV persistence remain unclear, there are clues that it may be related to protein–protein interactions (PPI) between viral proteins and cellular proteins involved in the interferon (IFN) response. Since FMDV persistence has been described in cattle, sheep and goats but not in swine, we screened PPI involving FMDV proteins and sixteen major type-I IFN p

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Hansberger, Mark W., Jacquelyn A. Campbell, Pranav Danthi та ін. "IκB Kinase Subunits α and γ Are Required for Activation of NF-κB and Induction of Apoptosis by Mammalian Reovirus". Journal of Virology 81, № 3 (2006): 1360–71. http://dx.doi.org/10.1128/jvi.01860-06.

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ABSTRACT Reoviruses induce apoptosis both in cultured cells and in vivo. Apoptosis plays a major role in the pathogenesis of reovirus encephalitis and myocarditis in infected mice. Reovirus-induced apoptosis is dependent on the activation of transcription factor NF-κB and downstream cellular genes. To better understand the mechanism of NF-κB activation by reovirus, NF-κB signaling intermediates under reovirus control were investigated at the level of Rel, IκB, and IκB kinase (IKK) proteins. We found that reovirus infection leads initially to nuclear translocation of p50 and RelA, followed by d

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Shamilov, Rambon, Olga Vinogradova, and Brian J. Aneskievich. "The Anti-Inflammatory Protein TNIP1 Is Intrinsically Disordered with Structural Flexibility Contributed by Its AHD1-UBAN Domain." Biomolecules 10, no. 11 (2020): 1531. http://dx.doi.org/10.3390/biom10111531.

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TNFAIP3 interacting protein 1 (TNIP1) interacts with numerous non-related cellular, viral, and bacterial proteins. TNIP1 is also linked with multiple chronic inflammatory disorders on the gene and protein levels, through numerous single-nucleotide polymorphisms and reduced protein amounts. Despite the importance of TNIP1 function, there is limited investigation as to how its conformation may impact its apparent multiple roles. Hub proteins like TNIP1 are often intrinsically disordered proteins. Our initial in silico assessments suggested TNIP1 is natively unstructured, featuring numerous poten

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Qu, Changju, Yadong Liu, Kranthi Kunkalla, Nitin K. Agarwal та Francisco Vega. "Smoothened (SMO) Activates NF-Kb Pathway Through Activation of PKCβ/CARMA1 and TRAF6 Stabilization in Diffuse Large B-Cell Lymphoma". Blood 120, № 21 (2012): 1298. http://dx.doi.org/10.1182/blood.v120.21.1298.1298.

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Abstract Abstract 1298 Aberrant activation of hedgehog (Hh) and NF-kB pathways contribute to tumor cell growth, survival and chemotolerance in diffuse large B-cell lymphoma (DLBCL). Previously, we documented a functional crosstalk between hedgehog (Hh) and NF-kB pathways that contribute to tumor cell growth and survival in diffuse large B-cell lymphoma (DLBCL). However, the molecular mechanisms that link Hh with NF-kB pathway have not been defined. Based on that smoothened (SMO) has been associated with heterotrimeric G protein members of the Gα i family and established as a GPCRs-like protein

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Panezai, Jeneen, Ambereen Ghaffar, Mohammad Altamash, et al. "Periodontal Disease Augments Cardiovascular Disease Risk Biomarkers in Rheumatoid Arthritis." Biomedicines 10, no. 3 (2022): 714. http://dx.doi.org/10.3390/biomedicines10030714.

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Objectives: Periodontal disease (PD) and rheumatoid arthritis (RA) are known chronic conditions with sustained inflammation leading to osteolysis. Cardiovascular diseases (CVD) are frequent comorbidities that may arise from sustained inflammation associated with both PD and RA. In order to determine CVD risk, alterations at the molecular level need to be identified. The objective of this study, therefore, was to assess the relationship of CVD associated biomarkers in RA patients and how it is influenced by PD. Methods: The study consisted of patient (26 RA with PD, 21 RA without PD, 51 patient

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Sandstedt, Joakim, Karin Vargmar, Kristina Björkman, et al. "COMP (Cartilage Oligomeric Matrix Protein) Neoepitope." Arteriosclerosis, Thrombosis, and Vascular Biology 41, no. 3 (2021): 1218–28. http://dx.doi.org/10.1161/atvbaha.120.314720.

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Objective: COMP (cartilage oligomeric matrix protein) is abundantly expressed in the cardiovascular system, cartilage, and atherosclerotic plaques. We investigated if the total COMP (COMPtotal) and COMP neoepitope (COMPneo) with other cardiovascular markers and clinical parameters could identify symptomatic carotid stenosis. Approach and Results: Blood samples were collected from patients with symptomatic carotid stenosis (stenosis, n=50), patients with stroke without carotid stenosis but small plaques (plaque, n=50), and control subjects (n=50). COMPtotal and COMPneo were measured using an EL

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Chen, Rui, Guangda Xin, and Xiaofei Zhang. "Long non-coding RNA HCP5 serves as a ceRNA sponging miR-17-5p and miR-27a/b to regulate the pathogenesis of childhood obesity via the MAPK signaling pathway." Journal of Pediatric Endocrinology and Metabolism 32, no. 12 (2019): 1327–39. http://dx.doi.org/10.1515/jpem-2018-0432.

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Abstract Background This study aimed to investigate the completing endogenous RNA (ceRNA) network involved in childhood obesity. Methods The microarray dataset GSE9624 was downloaded from the Gene Expression Omnibus (GEO) database. Differentially expressed long non-coding RNAs (lncRNAs) (DELs) and messenger RNAs (DEMs) were isolated between the childhood obesity and non-obesity tissue samples. Then, Gene Ontology (GO) functional and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses of isolated DEMs were performed. DELs and DEMs targeted miRNAs were predicted to construct a ce

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Ahn, Yong-Tae, Boli Huang, Lisa McPherson, Carol Clayberger, and Alan M. Krensky. "Dynamic Interplay of Transcriptional Machinery and Chromatin Regulates “Late” Expression of the Chemokine RANTES in T Lymphocytes." Molecular and Cellular Biology 27, no. 1 (2007): 253–66. http://dx.doi.org/10.1128/mcb.01071-06.

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ABSTRACT The chemokine RANTES (regulated upon activation normal T cell expressed and secreted) is expressed “late” (3 to 5 days) after activation in T lymphocytes. In order to understand the molecular events that accompany changes in gene expression, a detailed analysis of the interplay between transcriptional machinery and chromatin on the RANTES promoter over time was undertaken. Krüppel-like factor 13 (KLF13), a sequence-specific DNA binding transcription factor, orchestrates the induction of RANTES expression in T lymphocytes by ordered recruitment of effector molecules, including Nemo-li

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Ishitani, Tohru, Jun Ninomiya-Tsuji та Kunihiro Matsumoto. "Regulation of Lymphoid Enhancer Factor 1/T-Cell Factor by Mitogen-Activated Protein Kinase-Related Nemo-Like Kinase-Dependent Phosphorylation in Wnt/β-Catenin Signaling". Molecular and Cellular Biology 23, № 4 (2003): 1379–89. http://dx.doi.org/10.1128/mcb.23.4.1379-1389.2003.

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ABSTRACT The Wnt/β-catenin signaling pathway regulates many developmental processes by modulating gene expression. Wnt signaling induces the stabilization of cytosolic β-catenin, which then associates with lymphoid enhancer factor and T-cell factor (LEF-1/TCF) to form a transcription complex that activates Wnt target genes. Previously, we have shown that a specific mitogen-activated protein (MAP) kinase pathway involving the MAP kinase kinase kinase TAK1 and MAP kinase-related Nemo-like kinase (NLK) suppresses Wnt signaling. In this study, we investigated the relationships among NLK, β-catenin

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Martínez-Sánchez, Sara María, Horacio Pérez-Sánchez, José Antonio Gabaldón, José Abellán-Alemán, and Silvia Montoro-García. "Multifunctional Peptides from Spanish Dry-Cured Pork Ham: Endothelial Responses and Molecular Modeling Studies." International Journal of Molecular Sciences 20, no. 17 (2019): 4204. http://dx.doi.org/10.3390/ijms20174204.

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Food peptides contain a very wide range of diversified structures, which explains their diverse range of functional activities. Proatherogenic endothelium is related to vasoconstriction, inflammation, and oxidative stress. In this line, four synthetic bioactive peptides from dry-cured pork ham, previously identified according to their Angiotensin I Converting Enzyme (ACE) inhibitory capacity and high bioavailability, were tested. Among them, KPVAAP displayed an estimated IC50 of 59.22 µM for human ACE inhibition, and docking simulations demonstrated the consistency of the noncompetitive bindin

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Tereshchenko, S. Yu, and M. V. Smolnikova. "Congenitally impaired pattern-recognition receptors in pathogenesis of pediatric invasive and recurrent pneumococcal infection." Russian Journal of Infection and Immunity 9, no. 2 (2019): 229–38. http://dx.doi.org/10.15789/2220-7619-2019-2-229-238.

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Here we review currently available data showing that innate immune signs predisposing to recurrent and invasive pneumococcal infections were identified in children. Streptococcus pneumoniae (pneumococcus) belongs to Grampositive bacteria being the major cause of morbidity and mortality in infants, especially in developing countries and in communities with low socioeconomic status. Due to the lack of anti-pneumococcal vaccination, the significant proportion of pneumococcus carriers develop non-invasive (pneumonia, otitis media, sinusitis) and severe invasive (bacteremia/septicemia, meningitis)

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15

Gleason, Catherine E., Alban Ordureau, Robert Gourlay, J. Simon C. Arthur та Philip Cohen. "Polyubiquitin Binding to Optineurin Is Required for Optimal Activation of TANK-binding Kinase 1 and Production of Interferon β". Journal of Biological Chemistry 286, № 41 (2011): 35663–74. http://dx.doi.org/10.1074/jbc.m111.267567.

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TANK-binding kinase (TBK1) is essential for transcription of the interferon (IFN) β gene in response to lipopolysaccharide (LPS) and double-stranded RNA, but the molecular mechanisms that underlie the activation of TBK1 are incompletely understood. Previously, we identified the NF-κB essential modulator (NEMO)-related polyubiquitin-binding protein, optineurin (OPTN), as a novel binding partner of TBK1. To determine whether the ubiquitin-binding function of OPTN is involved in regulating TBK1 and IFNβ production, we generated a mouse in which wild-type optineurin was replaced by the polyubiquit

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16

Yang, Biaolong, Shiqi Chen, and Yuansheng Zang. "The Mechanism of Nemo-Like Kinase (NLK) in Non-Small Cell Lung Cancer (NSCLC) Cells by Regulating Vascular Endothelial Growth Factor (VEGF)." Journal of Biomaterials and Tissue Engineering 12, no. 12 (2022): 2352–57. http://dx.doi.org/10.1166/jbt.2022.3193.

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Nemo-like kinase (NLK) is abnormally expressed in several tumors, but its role in NSCLC have not been reported. Real time PCR and Western blot were used to assess NLK level in tumor tissues and adjacent tissues of NSCLC. NSCLC cell line A549 cells were divided into three groups; NC group and si-NLK group which was transfected with NLK negative control or NLK siRNA respectively followed by analysis of NLK expression by real time PCR and Western blot, cell proliferation by MTT assay, cell migration by cell wound healing assay, cell invasion by transwell chamber and MMP-9 and VEGF expression by W

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Jimi, Eijiro, та Takenobu Katagiri. "Critical Roles of NF-κB Signaling Molecules in Bone Metabolism Revealed by Genetic Mutations in Osteopetrosis". International Journal of Molecular Sciences 23, № 14 (2022): 7995. http://dx.doi.org/10.3390/ijms23147995.

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The nuclear factor-κB (NF-κB) transcription factor family consists of five related proteins, RelA (p65), c-Rel, RelB, p50/p105 (NF-κB1), and p52/p100 (NF-κB2). These proteins are important not only for inflammation and the immune response but also for bone metabolism. Activation of NF-κB occurs via the classic and alternative pathways. Inflammatory cytokines, such as tumor necrosis factor (TNF)-α and interleukin (IL)-1β, activate the former, and cytokines involved in lymph node formation, such as receptor activator of NF-κB ligand (RANKL) and CD40L, activate the latter. p50 and p52 double-knoc

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18

Björk, Albin, Gudny Ella Thorlacius, Johannes Mofors, et al. "Viral antigens elicit augmented immune responses in primary Sjögren’s syndrome." Rheumatology 59, no. 7 (2019): 1651–61. http://dx.doi.org/10.1093/rheumatology/kez509.

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Abstract Objectives Infections have been suggested in the pathogenesis of primary SS (pSS). Systematic studies of immune responses to microbial antigens in vivo may be performed during vaccination. In the present study, we therefore longitudinally followed patients with pSS and controls during split-virion influenza vaccination to identify pSS-specific cellular, transcriptomic and serological responses. Methods Patients without treatment (pSSUntr, n = 17), on hydroxychloroquine-treatment (pSSHCQ, n = 8), and healthy controls (n = 16) were included. Antibody titres were determined by ELISA. Pla

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Glynn, Rebecca A., Katharina E. Hayer, and Craig H. Bassing. "ATM-dependent Phosphorylation of Nemo SQ Motifs Is Dispensable for Nemo-mediated Gene Expression Changes in Response to DNA Double-Strand Breaks." Journal of Immunology, July 15, 2024. http://dx.doi.org/10.4049/jimmunol.2300139.

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Abstract In response to DNA double-strand breaks (DSBs), the ATM kinase activates NF-κB factors to stimulate gene expression changes that promote survival and allow time for cells to repair damage. In cell lines, ATM can activate NF-κB transcription factors via two independent, convergent mechanisms. One is ATM-mediated phosphorylation of nuclear NF-κB essential modulator (Nemo) protein, which leads to monoubiquitylation and export of Nemo to the cytoplasm where it engages the IκB kinase (IKK) complex to activate NF-κB. Another is DSB-triggered migration of ATM into the cytoplasm, where it pro

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Zhou, Yucheng, Zhaoyang Bu, Jing Qian та ін. "Brucella melitensis UGPase inhibits the activation of NF-κB by modulating the ubiquitination of NEMO". BMC Veterinary Research 17, № 1 (2021). http://dx.doi.org/10.1186/s12917-021-02993-9.

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Abstract Background UTP-glucose-1-phosphoryl transferase (UGPase) catalyzes the synthesis of UDP-glucose, which is essential for generating the glycogen needed for the synthesis of bacterial lipopolysaccharide (LPS) and capsular polysaccharide, which play important roles in bacterial virulence. However, the molecular function of UGPase in Brucella is still unknown. Results In this study, the ubiquitination modification of host immune-related protein in cells infected with UGPase-deleted or wild-type Brucella was analyzed using ubiquitination proteomics technology. The ubiquitination modificati

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Zhan, Wenjuan, Huifang Zhang, Yufei Su та Li Yin. "TRIM47 promotes HDM‐induced bronchial epithelial pyroptosis by regulating NEMO ubiquitination to activate NF‐κB/NLRP3 signaling". Cell Biology International, 20 травня 2024. http://dx.doi.org/10.1002/cbin.12186.

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AbstractAsthma is an inflammatory disease. Airway epithelial cell pyroptosis and cytokine secretion promote asthma progression. Tripartite motif 47 (TRIM47) belongs to the E3 ubiquitin ligase family and is associated with apoptosis and inflammation in a range of diseases. However, the role of TRIM47 in asthma has not been explored. In this study, the human bronchial epithelial cell line BEAS‐2B was treated with house dust mite (HDM) and TRIM47 expression was detected by RT‐qPCR and Western blot. After transfection with TRIM47 interfering and overexpressing plasmids, the synthesis and secretion

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Ye. "Finding a novel interacting protein of the hepatic carcinoma related gene MIP: NF-κB essential modulator (NEMO)". Oncology Reports 25, № 1 (2010). http://dx.doi.org/10.3892/or_00001065.

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Sato, Yusuke, Seigo Terawaki, Daisuke Oikawa, et al. "Involvement of heterologous ubiquitination including linear ubiquitination in Alzheimer’s disease and amyotrophic lateral sclerosis." Frontiers in Molecular Biosciences 10 (January 16, 2023). http://dx.doi.org/10.3389/fmolb.2023.1089213.

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In neurodegenerative diseases such as Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS), the progressive accumulation of ubiquitin-positive cytoplasmic inclusions leads to proteinopathy and neurodegeneration. Along with the seven types of Lys-linked ubiquitin chains, the linear ubiquitin chain assembly complex (LUBAC)-mediated Met1-linked linear ubiquitin chain, which activates the canonical NF-κB pathway, is also involved in cytoplasmic inclusions of tau in AD and TAR DNA-binding protein 43 in ALS. Post-translational modifications, including heterologous ubiquitination, affect

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Lin, Yuanbang, Mingwei Sheng, Hua Qin та ін. "Caspase 6 promotes innate immune activation by functional crosstalk between RIPK1-IκBα axis in liver inflammation". Cell Communication and Signaling 21, № 1 (2023). http://dx.doi.org/10.1186/s12964-023-01287-x.

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Abstract Background Caspase 6 is an essential regulator in innate immunity, inflammasome activation and host defense. We aimed to characterize the causal mechanism of Caspase 6 in liver sterile inflammatory injury. Methods Human liver tissues were harvested from patients undergoing ischemia-related hepatectomy to evaluate Caspase 6 expression. Subsequently, we created Caspase 6-knockout (Caspase 6KO) mice to analyze roles and molecular mechanisms of macrophage Caspase 6 in murine models of liver ischemia/reperfusion (IR) injury. Results In human liver biopsies, Caspase 6 expression was positiv

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Bhuiyan, Mohammad Iqbal H., Cullen B. Young, Israt Jahan та ін. "NF-κB Signaling-Mediated Activation of WNK-SPAK-NKCC1 Cascade in Worsened Stroke Outcomes of Ang II–Hypertensive Mice". Stroke, 11 березня 2022. http://dx.doi.org/10.1161/strokeaha.121.038351.

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Background: Worsened stroke outcomes with hypertension comorbidity are insensitive to blood pressure-lowering therapies. In an experimental stroke model with comorbid hypertension, we investigated causal roles of ang II (angiotensin II)–mediated stimulation of the brain WNK (with no lysine [K] kinases)-SPAK (STE20/SPS1-related proline/alanine-rich kinase)-NKCC1 (Na-K-Cl cotransporter) complex in worsened outcomes. Methods: Saline- or ang II–infused C57BL/6J male mice underwent stroke induced by permanent occlusion of the distal branches of the middle cerebral artery. Mice were randomly assigne

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He, Li-Bin, Hui-Yu Luo, and Le-Yun Zheng. "Atmosphere and room temperature plasma alters the m6A methylome profiles and regulates gene expression associated with color mutation in clownfish (Amphiprion ocellaris)." Frontiers in Marine Science 10 (June 9, 2023). http://dx.doi.org/10.3389/fmars.2023.1173215.

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Since the release of the movie Finding Nemo, clownfish have been known and loved by many people. Clownfish have a very vivid skin color and extreme ornamental value. However, there are few species of clownfish, which greatly limits the breeding of new varieties. In this study, the Atmosphere and room temperature plasma (ARTP) method was used to treat clownfish-fertilized eggs and successfully screened out mutants that exhibited a skin color change from black to red in their offspring. To elucidate the molecular mechanism underlying this color mutation, more than 17,000 methylated peaks were ob

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Alshafie, Walaa, Maryam Fotouhi, Irina Shlaifer, Thomas M. Durcan, Peter S. McPherson, and Carl Laflamme. "Antibody Characterization Report for Optineurin." April 30, 2021. https://doi.org/10.5281/zenodo.4730992.

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Head to head comparison of available commercial antibodies against Optineurin by immunoblot (Western blot), immunoprecipitation and immunofluorescence. The following study was funded in part by Genome Québec's Genomics Integration Program, awarded to the laboratory of Peter S. McPherson. This work is part of the ALS-Reproducible Antibody Platform (ALS-RAP), established as a public-private partnership by three prominent ALS charities - the ALS Association (USA), the Motor Neurone Disease Association (UK), and the ALS Society of Canada.

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Ruíz, Moleón Vera, Maryam Fotouhi, Charles Alende, et al. "Antibody Characterization Report for Optineurin (2023)." November 9, 2023. https://doi.org/10.5281/zenodo.10091740.

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This report presents a guide to selecting high-quality commercial antibodies against Optineurin by immunoblot (Western blot), immunoprecipitation and immunofluorescence, using a knockout based validation approach. The research displayed in this study can be considered a subsequent study following the initial Optineurin report published to the YCharOS community in 2021 (DOI:10.5281/zenodo.4730992). Antibodies ab213556**, 60293-1-Ig*, 702766** and 711879**, previously characterized in the initial report, were retested in all three applications, employing our revised standardized protocols.

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Dahlin, Maria, Tommy Stödberg, Elin Ekman, Virpi Töhönen, and Anna Wedell. "Genetic aetiologies in relation to response to the ketogenic diet in 226 children with epilepsy." Brain Communications, April 5, 2025. https://doi.org/10.1093/braincomms/fcaf134.

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Abstract A ketogenic diet is used in children with drug-resistant epilepsy but predictors for efficacy are largely lacking. Our aim was to evaluate if causative genetic variants could predict seizure response to the ketogenic diet. A cohort study of 226 children with refractory epilepsy and classic ketogenic diet treatment for at least 3 months (76.9% of the 294 who started) was performed. The median age at diet start was 5.1 years (range 0.1-17.8), 118 were girls and 108 boys. They had previous trials of a median of 6.0 antiseizure medications (range 0-12) and intellectual disability was foun

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Briggs, Louise C., A. W. Edith Chan, Christopher A. Davis та ін. "IKKγ-Mimetic Peptides Block the Resistance to Apoptosis Associated with Kaposi's Sarcoma-Associated Herpesvirus Infection". Journal of Virology 91, № 23 (2017). http://dx.doi.org/10.1128/jvi.01170-17.

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ABSTRACT Primary effusion lymphoma (PEL) is a lymphogenic disorder associated with Kaposi's sarcoma-associated herpesvirus (KSHV) infection. Key to the survival and proliferation of PEL is the canonical NF-κB pathway, which becomes constitutively activated following overexpression of the viral oncoprotein KSHV vFLIP (ks-vFLIP). This arises from its capacity to form a complex with the modulatory subunit of the IκB kinase (IKK) kinase, IKKγ (or NEMO), resulting in the overproduction of proteins that promote cellular survival and prevent apoptosis, both of which are important drivers of tumorigen

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