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Dissertations / Theses on the topic 'Neonatal Respiratory Distress Syndrome'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Ainsworth, Sean B. "The impact of exogenous surfactant in neonatal respiratory distress syndrome." Thesis, University of Edinburgh, 2002. http://hdl.handle.net/1842/23306.

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Several exogenous surfactants are currently available and whilst controlled trials have demonstrated surfactant therapy is better than placebo, there are several unanswered questions that this thesis addresses through a review of existing evidence; 1. Which surfactant preparation is clinically more efficacious? 2. The choice between “rescue” (treatment after the development of RDS) or “prophylaxis” (prevention of RDS). 3. How many doses of surfactant are needed and what is the evidence for the size of the doses currently used? Four exogenous surfactant preparations - two synthetic and two anim

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2

Sefic, Pasic Irmina. "The role of lung ultrasonography in the evaluation of neonatal respiratory distress syndrome." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/669429.

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Objetivo de nuestro estudio fue evaluar la capacidad diagnóstica de la ecografía pulmonar en el diagnóstico del Síndrome del Distrés Respiratorio (SDR), así como en el seguimiento de la respuesta al tratamiento. La ecografía pulmonar se comparó con los rayos X como método estándar de diagnóstico y seguimiento de pacientes con SDR. La escala radiográfica de cuatro grados se comparó con perfiles de ultrasonido de tres grados. El segundo objetivo era hacer un cálculo de las dosis recibidas debido a la radiografía de tórax en niños incluidos en el estudio. También se compararon los hallazgos

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3

Clark, Simon John. "Right ventricular function in respiratory distress syndrome." Thesis, University of Liverpool, 2001. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250478.

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4

Raine, Joseph. "The use of continuous negative extrathoracic pressure in the neonatal respiratory distress syndrome." Thesis, University of Manchester, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.508168.

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Our aim was to re-evaluate the role of CNEP in RDS using a modified CNEP chamber. The new CNEP system comprised a thin (0.25 mm) rubber neck seal, facilities for routine and emergency patient access and an air controlled incubator heater. The protocol of the randomised controlled trial of CNEP in RDS is presented. There were 122 matched pairs in the trial. The trial showed that CNEP leads to a fall in the mean duration of oxygen therapy (-15.3, 95% CI -30.4 to -0.2 days), and to a decrease in the incidence of BPD (-12, 95% CI -23 to -1%). Patients in the CNEP limb also had a substantially decr

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5

Saha, Sipra. "mPGES-1 : a key regulator of fever and neonatal respiratory depression /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-750-2/.

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6

St, Clair Caryn M. "Neonatal Respiratory Distress Syndrome as a Function of Gestational Age and the Lecithin/Sphingomyelin Ratio." [New Haven, Conn. : s.n.], 2007. http://ymtdl.med.yale.edu/theses/available/etd-08272007-123115/.

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7

Espinosa, Frank F. (Frank Francis). "Exogenous surfactant transport through the pulmonary airways : improving surfactant replacement therapy for neonatal respiratory distress syndrome." Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/10974.

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8

Mockridge, J. N. A. "A computer-controlled synchronous ventilator for neonates." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282930.

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9

Haataja, R. (Ritva). "The role of surfactant protein A and B genes in heritable susceptibility to neonatal respiratory distress syndrome." Doctoral thesis, University of Oulu, 2001. http://urn.fi/urn:isbn:9514265254.

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Abstract Respiratory distress syndrome (RDS) is a disease characterized by neonatal respiratory failure. It is principally caused by a deficiency of pulmonary surfactant, which is a lipoprotein mixture essential for reducing surface tension at the air-liquid interface of the alveolus. Prematurity is the major risk factor predisposing to RDS. Several pieces of evidence suggest the role of genetic factors in the susceptibility to this multifactorial disease. The present study was performed to determine whether polymorphisms of the surfactant protein SP-A1, SP-A2 and SP-B genes associate

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10

Jorgensen, Ashley. "Comparison of poractant versus beractant in the treatment of respiratory distress syndrome in premature neonates in a tertiary academic medical center." The University of Arizona, 2012. http://hdl.handle.net/10150/623645.

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Class of 2012 Abstract<br>Specific Aims: The objective of this study is to evaluate and compare clinical outcomes and economic impact involved with the use of beractant (B) compared to poractant (P) for the treatment of respiratory distress syndrome (RDS) in premature neonates admitted to a neonatal intensive care unit. Methods: Patients were included if they were less than 35 weeks gestational age at birth, survived at least 48 hours, and admitted to the neonatal intensive care unit and treated with P or B for RDS. The primary outcome of this study is the change in the fraction of inspired o

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11

Hendriks, Hans Jurgen. "Is CPAP a feasible treatment modality in a rural district hospital for neonates with respiratory distress syndrome." Thesis, Stellenbosch : University of Stellenbosch, 2015. http://hdl.handle.net/10019.1/97244.

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Introduction: Limited facilities exist at rural hospitals for the management of newborn infants with respiratory distress syndrome (RDS). Furthermore, the secondary and tertiary hospitals are under severe strain to accept all the referrals from rural hospitals. Many of these infants require intubation and ventilation with a resuscitation bag which must be sustained for hours until the transport team arrives. Not only is lung damage inflicted by the prolonged ventilation, but transferring the infant by helicopter and ambulance is expensive. CPAP (continuous positive airway pressure), a non-

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12

Alves, Alexssandra Maia. "Morbidade RespiratÃria Neonatal e Fatores Associados ao Ãbito por SÃndrome do Desconforto RespiratÃrio em Unidades de Terapia Intensiva no MunicÃpio de Fortaleza." Universidade Federal do CearÃ, 2009. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=4609.

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Este estudo teve como objetivo descrever o perfil e o padrÃo de prÃticas assistenciais de recÃm-nascidos com distÃrbios respiratÃrios, internados nas unidades de terapia intensiva em Fortaleza e analisar fatores associados ao Ãbito em recÃm-nascidos de muito baixo peso com SÃndrome do Desconforto RespiratÃrio. Trata-se de um estudo de coorte prospectiva de base hospitalar, realizado em 773 recÃm-nascidos em cinco hospitais, de julho a dezembro de 2007. Foram duas etapas uma descritiva e a outra, analÃtica. A maioria era prÃ-termo (80,7%). Entre o primeiro e quinto minuto, houve queda no Apgar

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13

Carvalho, Marcos Giovanni Santos. "Avaliação das repercussões da corticoterapia pré-natal em recém-nascidos em maternidade de referência de Manaus - AM." Universidade Federal do Amazonas, 2012. http://tede.ufam.edu.br/handle/tede/2305.

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Made available in DSpace on 2015-04-11T13:41:12Z (GMT). No. of bitstreams: 1 Marcos Giovanni Santos Carvalho.pdf: 4299748 bytes, checksum: 026ddef622b0abee7f254cf45582e0de (MD5) Previous issue date: 2012-11-23<br>CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Introduction: Prematurity is a serious problem for health services across the world, and the respiratory distress syndrome (RDS) is the largest lung problem during the neonatal period. The deployment of new technologies such as prenatal corticosteroids has shown an important role in reducing neonatal morbidity

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14

Nasrollah, Kimia. "Comparison of poractant versus beractant in the treatment of respiratory distress syndrome in premature neonates in a tertiary academic medical center." The University of Arizona, 2012. http://hdl.handle.net/10150/623606.

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Class of 2012 Abstract<br>Specific Aims: The purpose of this study is to evaluate and compare clinical outcomes and cost involved with use of poractant versus beractant for the treatment of respiratory distress syndrome (RDS) in a level III, neonatal intensive care unit (NICU) within an academic medical center. Methods: This retrospective cohort study included patients if they were admitted to the NICU for RDS between April 1, 2010 to November 30, 2010 and December 1, 2010 to June 30, 2011 treated with beractant and poractant respectively. Patients were excluded from the study if they were gr

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15

Nasrollah, Kimia, and Hanna Phan. "Comparison of Poractant Versus Beractant in the Treatment of Respiratory Distress Syndrome in Premature Neonates in a Tertiary Academic Medical Center." The University of Arizona, 2012. http://hdl.handle.net/10150/614483.

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Class of 2012 Abstract<br>Specific Aims: The purpose of this study is to evaluate and compare clinical outcomes and cost involved with use of poractant versus beractant for the treatment of respiratory distress syndrome (RDS) in a level III, neonatal intensive care unit (NICU) within an academic medical center. Methods: This retrospective cohort study included patients if they were admitted to the NICU for RDS between April 1, 2010 to November 30, 2010 and December 1, 2010 to June 30, 2011 treated with beractant and poractant respectively. Patients were excluded from the study if they were

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16

Guimarães, André Gustavo Moura. "Influência da dor neonatal e as variáveis fisiológicas mediante as condutas fisioterapêuticas em prematuros com síndrome do desconforto respiratório na unidade de terapia intensiva." Universidade Nove de Julho, 2018. http://bibliotecatede.uninove.br/handle/tede/1888.

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Submitted by Nadir Basilio (nadirsb@uninove.br) on 2018-07-20T19:48:50Z No. of bitstreams: 1 André Gustavo Moura Guimarães.pdf: 1691381 bytes, checksum: b4f575802538a0af96f868e24171236c (MD5)<br>Made available in DSpace on 2018-07-20T19:48:50Z (GMT). No. of bitstreams: 1 André Gustavo Moura Guimarães.pdf: 1691381 bytes, checksum: b4f575802538a0af96f868e24171236c (MD5) Previous issue date: 2018-03-06<br>Introduction: neonatal pain results in neurobiological effects, and changes in behavioral reactions of children who were born prematurely. There is no clear description about the pain caused b

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17

Hendriks, Hans Jurgen. "Is CPAP a feasible treatment modality in a rural district hospital for neonates with respiratory distress syndrome?" Thesis, Stellenbosch : Stellenbosch University, 2010. http://hdl.handle.net/10019.1/20453.

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Thesis (MMed) -- Stellenbosch University, 2010.<br>ENGLISH ABSTRACT: Introduction: Limited facilities exist at rural hospitals for the management of newborn infants with respiratory distress syndrome (RDS). Furthermore, the secondary and tertiary hospitals are under severe strain to accept all the referrals from rural hospitals. Many of these infants require intubation and ventilation with a resuscitation bag which must be sustained for hours until the transport team arrives. Not only is lung damage inflicted by the prolonged ventilation, but transferring the infant by helicopter and ambulanc

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18

Jorgensen, Ashley, and Hanna Phan. "Comparison of Poractant Versus Beractant in the Treatment of Respiratory Distress Syndrome in Premature Neonates in a Tertiary Academic Medical Center." The University of Arizona, 2012. http://hdl.handle.net/10150/614514.

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Class of 2012 Abstract<br>Specific Aims: The objective of this study is to evaluate and compare clinical outcomes and economic impact involved with the use of beractant (B) compared to poractant (P) for the treatment of respiratory distress syndrome (RDS) in premature neonates admitted to a neonatal intensive care unit. Methods: Patients were included if they were less than 35 weeks gestational age at birth, survived at least 48 hours, and admitted to the neonatal intensive care unit and treated with P or B for RDS. The primary outcome of this study is the change in the fraction of inspired

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19

Lucheta, Thaís Giorgeto Pereira [UNESP]. "Doenças respiratórias neonatais em prematuros de mães hipertensas e normotensas." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/99232.

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Made available in DSpace on 2014-06-11T19:29:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-02-25Bitstream added on 2014-06-13T19:39:23Z : No. of bitstreams: 1 lucheta_tgp_me_botfm.pdf: 272316 bytes, checksum: 26f7a39028c22662ca263fe0ec2a7d86 (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>As síndromes hipertensivas da gestação constituem importante causa de prematuridade. Os distúrbios respiratórios representam a principal morbidade de prematuros e a literatura é controversa quanto ao prognóstico respiratório de prematuros de mães hipertensas. Investigar

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20

Lucheta, Thaís Giorgeto Pereira. "Doenças respiratórias neonatais em prematuros de mães hipertensas e normotensas /." Botucatu : [s.n.], 2011. http://hdl.handle.net/11449/99232.

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Orientador: Lígia Maria Suppo Souza Rugolo<br>Banca: Lilian Dos Santos Rodrigues Sadeck<br>Banca: Maria Regina Bentlin<br>Resumo: As síndromes hipertensivas da gestação constituem importante causa de prematuridade. Os distúrbios respiratórios representam a principal morbidade de prematuros e a literatura é controversa quanto ao prognóstico respiratório de prematuros de mães hipertensas. Investigar a incidência de doenças respiratórias em prematuros e a associação entre as síndromes hipertensivas da gestação e a síndrome do desconforto respiratório (SDR). Estudo unicêntrico, observacional prosp

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21

Peltoniemi, O. M. (Outi-Maria). "Corticosteroid treatment in the perinatal period:efficacy and safety of antenatal and neonatal corticosteroids in the prevention of acute and long-term morbidity and mortality in preterm infants." Doctoral thesis, University of Oulu, 2007. http://urn.fi/urn:isbn:9789514284601.

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Abstract The aim of the study was to evaluate the efficacy and safety of antenatal and postnatal corticosteroids in the prevention for mortality and acute and long-term morbidity in preterm infants. Altogether 109 eligible preterm infants participated in a randomized, multi-center, double-blinded controlled trial studying the efficacy of early dexamethasone (DX) treatment. The infants received either four doses of DX or placebo. DX treatment did not have a detectable influence on survival without bronchopulmonary dysplasia (BPD), severe intracranial hemorrhage, or periventricular leukomalacia

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22

Rocker, Graeme Martin. "Studies on adult respiratory distress syndrome." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235866.

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23

Wetterberg, Torbjörn. "Treatment of critical respiratory failure in adult respiratory distress syndrome." Lund : Dept. of Anesthesiology and Intensive Care, Lund University, University Hospital, 1992. http://books.google.com/books?id=WBVsAAAAMAAJ.

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24

Dushianthan, Ahilanandan. "Phospholipid kinetics in acute respiratory distress syndrome." Thesis, University of Southampton, 2014. https://eprints.soton.ac.uk/374568/.

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25

Davet, Dominique. "A nonlinear model of heart rate variability applied to cardiorespiratory interactions in adults and infants." Thesis, Georgia Institute of Technology, 1988. http://hdl.handle.net/1853/17614.

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26

Henderson, William Roy. "Expiratory time constant heterogeneity in experimental acute respiratory distress syndrome." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/58370.

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Purpose This thesis evaluated regional heterogeneity of pulmonary mechanical values within models of lung injury. To this end four separate studies were completed. I evaluated regional expiratory time constant (τE) heterogeneity and tissue strain (ε) in a lung model using functional respiratory imaging (FRI) (Study 1, Chapter 2), and developed an in vivo porcine model of lung injury (Study 2, Chapter 3). This model was used to assess changes in τE due to manipulations of respiratory gas density (Study 3, Chapter 4) and mechanical ventilation parameters (Study 4, Chapter 5). Methods Study

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27

San, Angelo Donna. "THE EFFECT OF BODY POSITION ON RESPIRATORY FUNCTION IN THE INFANT WITH RESPIRATORY DISTRESS SYNDROME." Thesis, The University of Arizona, 1986. http://hdl.handle.net/10150/275429.

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28

Muzaffar, Saima. "Reactive oxygen species and the pathophysiology of adult respiratory distress syndrome." Thesis, University of Bristol, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271916.

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29

Greene, Michelle Kathleen. "Therapeutic evaluation of an immunomodulatory nanoparticle in acute respiratory distress syndrome." Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.680123.

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Acute Respiratory Distress Syndrome (ARDS) is characterised by dysregulated inflammation within the lungs, which can severely compromise pulmonary architecture and function. Despite intensive efforts to develop therapies for ARDS, there are no curative pharmacological interventions at present. Instead, management of ARDS is primarily supportive and the syndrome is associated with substantial mortality, morbidity and healthcare expenditure. In pursuit of an effective ARDS therapy, this thesis explored the potential application of a novel sialic acid-functionalised nanoparticle (SNP). This nanop

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30

Lidegran, Marika. "Advanced radiological imaging in patients treated with extracorporeal membrane oxygenation /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-933-5/.

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31

Thommasen, Harvey Victor. "The role of the polymorphonuclear leukocyte in the pathogenesis of the adult respiratory distress syndrome." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/25058.

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This study was designed to follow up a chance observation in patients with an admission white blood cell (WBC) count showing an absolute lymphocytosis and relative neutropenia that changed to a lymphopenia and neutrophilia within 24 hours. As 15 of the 20 patients were admitted following trauma, we examined this association further by reviewing charts of 69 patients who had sustained stab wounds to the chest and abdomen. A prospective study involving 40 patients in the Intensive Care Unit was also undertaken because of the related hypothesis that the Adult Respiratory Distress Syndrome (ARD

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32

Wang, Jiu-Yao. "Expression and functional characterization of carbohydrate recognition domains of bovine conglutinin and human lung surfactant protein D." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318456.

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33

Davreux, Christopher J. "Antioxidant therapy for the management and prevention of adult respiratory distress syndrome." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0003/MQ34060.pdf.

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34

Lindwall, Robert B. I. "Respiratory distress syndrome : aspects of inhaled nitric oxide surfactant and nasal CPAP /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-297-7/.

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35

Halahakoon, W. L. D. C. N. "A study of cerebral function following surfactant treatment for respiratory distress syndrome." Thesis, Queen's University Belfast, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301741.

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36

Jia, Xiaoming M. Eng Massachusetts Institute of Technology. "The effects of mechanical ventilation on the development of Acute Respiratory Distress Syndrome." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/41629.

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Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2007.<br>Includes bibliographical references (p. 74-76).<br>Acute Respiratory Distress Syndrome (ARDS) is a severe lung illness characterized by inflammation and fluid accumulation in the respiratory system. Historically, ARDS and other forms of respiratory failure have been treated using mechanical ventilation to help maintain gas exchange in the lungs. However, clinical investigators are beginning to discover the adverse effects of mechanical ventilation if it is not applied properl

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37

ISAK, ILENA. "STABLE ISOTOPE TRACERS TO ESTIMATE SURFACTANT METABOLISM IN NEWBORNS WITH RESPIRATORY DISTRESS SYNDROME." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3427467.

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Aims of the thesis are to describe new applications of stable isotope tracers, applied to study pulmonary surfactant kinetics in human newborns. My PhD project was initially focused on the most suitable metabolic substrate to measure surfactant DSPC synthesis and more specifically on the difference between de-novo synthesis an remodeling synthesis using free fatty acids derived from the circulating blood. In the second part a newly synthesized stable isotope tracer, 2H3-U13C PA-DPPC, was used to investigate the different kinetics of the sn-1 and sn-2 palmitate moieties in infants with differ

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38

Jordan, Simon James. "The pathogenesis of lung injury following cardiothoracic surgery." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249727.

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39

Quinlan, Gregory John. "Oxidative damage to extracellular proteins and lipids during acute lung injury." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281713.

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40

Aggarwal, Anjna. "Mediators and mechanisms of persistent pulmonary neutrophilia in acute lung injury." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289880.

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41

Peters, Mark John. "The role of platelets in acute inflammation." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271069.

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42

Rocksʹen, David. "Acute lung injury : study of pathogenesis and therapeutic interventions /." Umeå : Univ, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-161.

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43

Harkin, Denis William. "Modulation of the systemic inflammatory response syndrome in lower limb ischaemia-reperfusion injury." Thesis, Queen's University Belfast, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326388.

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44

Zhai, Ruoyang. "Effects of sevoflurane in the treatment of Acute Respiratory Distress Syndrome : a translational approach." Electronic Thesis or Diss., Université Clermont Auvergne (2021-...), 2023. http://www.theses.fr/2023UCFA0077.

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Le syndrome de détresse respiratoire aiguë est une cause majeure d'insuffisance respiratoire avec un taux de mortalité élevé. Elle se caractérise par des lésions alvéolaires diffuses, un œdème alvéolaire et une défaillance respiratoire hypoxémique qui entraînent de lourds coûts de santé. Actuellement, les traitements disponibles pour le SDRA restent principalement de soutien, et aucune approche pharmacologique n'est traduite avec succès en application clinique. Il existe deux processus majeurs au cours du développement physiopathologique du SDRA qui conduisent à la formation d'un œdème pulmona

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45

Todd, Susan Katharine. "Shock assisted ventilation." Thesis, University of Surrey, 1999. http://epubs.surrey.ac.uk/843314/.

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Respiratory distress syndrome is the major cause of mortality in premature babies. Increasing numbers of neonates are now surviving the disease due to advances in techniques used in neonatal intensive care units. Mechanical ventilation is an essential part of the treatment for respiratory distress syndrome and is an area in which improvements and modifications are constantly being made. In the early 1980's a new infant ventilator was introduced involving ventilation by a distal jet. As yet, the mechanisms by which the distal jet ventilator enhances gas exchange are unknown. Original experiment

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46

Baker, Cathy Sue. "Rationale for surfactant replacement therapy in patients with acute lung injury." Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243281.

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47

Pitt, Tracy Shawn. "Effects of temperature and anticoagulant on the in vitro quantitation of Leukocyre Expressed Mac-1 and Post-traumatic assay to predict the development of ARDS." Youngstown State University / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ysu996864777.

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48

Bätzel, Carolin. "Verbesserung der medizinischen Versorgung und des Outcomes sehr kleiner und leichter Frühgeborener durch klinisches Benchmarking." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2006. http://dx.doi.org/10.18452/15454.

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In der vorliegenden Arbeit wurde anhand der im Rahmen des Vermont-Oxford-Neonatal-Networks erhobenen Daten an der Berliner Klinik für Neonatologie der Charité Campus Mitte und der Abteilung für neonatologische Intensivmedizin der Universitätskinderklinik in Innsbruck ein Benchmarking-Projekt für die Jahre 1997 bis 2001 durchgeführt. Nach der Analyse des Outcomes wurde eine Analyse der externen Evidenz anhand von Literatursuche in PubMed und der Cochrane Datenbank für systematische Reviews durchgeführt. Danach wurde ein Fragebogen entworfen, der gezielt Handlungsstrategien und -richtlinien bezü

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49

Camprubí, Rimblas Marta. "Nebulized anti-coagulants as a therapy for acute lung injury and acute respiratory distress syndrome." Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/663961.

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La síndrome de distrés respiratori agut (ARDS) és una insuficiència respiratòria aguda amb una incidència global a Europa de 17,9 per cada 100.000 persones-any. Tot i els avenços en el tractament de suport dels pacients amb ARDS, la mortalitat continua sent alta (40%) i els pacients que sobreviuen presenten seqüeles persistents. Actualment no existeix un tractament efectiu. La fisiopatologia de l’ARDS es caracteritza per l’activació de la coagulació i la inflamació a nivell pulmonar, juntament amb el trencament de la barrera alveolar-capil·lar. Això comporta la formació d’edema proteic, la in

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Morrison, Thomas. "Human mesenchymal stromal cell regulation of pulmonary macrophage populations in the Acute Respiratory Distress Syndrome." Thesis, Queen's University Belfast, 2017. https://pure.qub.ac.uk/portal/en/theses/human-mesenchymal-stromal-cell-regulation-of-pulmonary-macrophage-populations-in-the-acute-respiratory-distress-syndrome(da547b07-7974-436a-8943-7e2ddf3933cc).html.

Full text

Abstract:

The Acute Respiratory Distress Syndrome (ARDS) is a devastating clinical disorder characterised by excessive inflammation in the alveolar compartment resulting in oedema of the airspaces due to loss of integrity in the alveolar epithelial-endothelial barrier. ARDS is associated with high mortality rates and there are currently no effective pharmacological therapies available. Human Mesenchymal Stromal Cells (hMSCs) are a promising candidate therapy which are currently being investigated in clinical trials for ARDS. However their mechanisms of effects in lung injury are not fully elucidated. A

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