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Journal articles on the topic 'Neonatal Seizure Detector'

Author: Grafiati

Published: 14 March 2023

Last updated: 31 July 2025

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1

Chen, Hongyu, Zaihao Wang, Chunmei Lu, et al. "Neonatal Seizure Detection Using a Wearable Multi-Sensor System." Bioengineering 10, no. 6 (2023): 658. http://dx.doi.org/10.3390/bioengineering10060658.

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Neonatal seizure is an important clinical symptom of brain dysfunction, which is more common in infancy than in childhood. At present, video electroencephalogram (VEEG) technology is widely used in clinical practice. However, video electroencephalogram technology has several disadvantages. For example, the wires connecting the medical instruments may interfere with the infant’s movement and the gel patch electrode or disk electrode commonly used to monitor EEG may cause skin allergies or even tears. For the above reasons, we developed a wearable multi-sensor platform for newborns to collect ph

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Ansari, Amir H., Perumpillichira J. Cherian, Alexander Caicedo, Gunnar Naulaers, Maarten De Vos, and Sabine Van Huffel. "Neonatal Seizure Detection Using Deep Convolutional Neural Networks." International Journal of Neural Systems 29, no. 04 (2019): 1850011. http://dx.doi.org/10.1142/s0129065718500119.

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Identifying a core set of features is one of the most important steps in the development of an automated seizure detector. In most of the published studies describing features and seizure classifiers, the features were hand-engineered, which may not be optimal. The main goal of the present paper is using deep convolutional neural networks (CNNs) and random forest to automatically optimize feature selection and classification. The input of the proposed classifier is raw multi-channel EEG and the output is the class label: seizure/nonseizure. By training this network, the required features are o

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Borovac, Ana, Thomas Philip Runarsson, Gardar Thorvardsson, and Steinn Gudmundsson. "Neonatal seizure detection algorithms: The effect of channel count." Current Directions in Biomedical Engineering 8, no. 2 (2022): 604–7. http://dx.doi.org/10.1515/cdbme-2022-1154.

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Abstract The number of electrodes used to acquire neonatal EEG signals varies between institutions. Therefore, tools for automatic EEG analysis, such as neonatal seizure detection algorithms, need to be able to handle different electrode montages in order to find widespread use. The aim of this study was to analyse the effect of montage on neonatal seizure detector performance. A full 18-channel montage was compared to reduced 3- and 8-channel montages using a convolutional neural network for seizure detection. Sensitivity decreased by 10 - 18 % for the reduced montages while specificity was m

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Duckworth, Eleanor, Daniyal Motan, Kitty Howse, Stewart Boyd, Ronit Pressler, and Maria Chalia. "Diagnostic Accuracy of the Persyst Automated Seizure Detector in the Neonatal Population." Journal of Integrative Neuroscience 23, no. 8 (2024): 150. http://dx.doi.org/10.31083/j.jin2308150.

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Temko, Andriy, William Marnane, Geraldine Boylan, and Gordon Lightbody. "A Data-Driven Energy Based Estimator of EEG Channel Importance for Improved Patient-Adaptive Neonatal Seizure Detector." IFAC Proceedings Volumes 44, no. 1 (2011): 13770–75. http://dx.doi.org/10.3182/20110828-6-it-1002.03457.

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Buraniqi, Ersida, Arnold J. Sansevere, Kush Kapur, Ann M. Bergin, Phillip L. Pearl, and Tobias Loddenkemper. "Electrographic Seizures in Preterm Neonates in the Neonatal Intensive Care Unit." Journal of Child Neurology 32, no. 10 (2017): 880–85. http://dx.doi.org/10.1177/0883073817713918.

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Objective: Characterize clinical and electroencephalography (EEG) characteristics of preterm neonates undergoing continuous EEG in the neonatal intensive care unit. Methods: Retrospective study of preterm neonates born less than 37 weeks’ gestational age undergoing continuous EEG in the neonatal intensive care unit at Boston Children’s Hospital over a 2-year period. Results: Fifty-two preterms (46% male) had a mean gestational age of 32.8 weeks (standard deviation = 4.17). Seizures were detected in 12/52 (23%), with EEG seizures detected in 4/12 (33%). The median time from EEG to the first sei

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Durgesh, Kannam, and Sandeep Reddy Chinthireddy. "A Study of Clinical and Biochemical Profile of Neonatal Seizures." International Journal of Toxicological and Pharmacological Research 12, no. 11 (2022): 1–7. https://doi.org/10.5281/zenodo.11420695.

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<strong>Background:</strong> One of the most prevalent and recognizable clinical signs of a neurological system in failure is neonatal seizures. Neonatal seizures are the outcome of the developing nervous system’s reactions to various shocks and can cause significant neonatal death and morbidity as well as childhood physical and cognitive deficits. Preterm infants are more likely to experience newborn seizures than term infants, and metabolic disorders are a frequent cause of neonatal seizures. <strong>Methods:</strong> Based on the inclusion and exclusion criteria a total

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Buttle, Sarah Grace, Brigitte Lemyre, Erick Sell, et al. "Combined Conventional and Amplitude-Integrated EEG Monitoring in Neonates: A Prospective Study." Journal of Child Neurology 34, no. 6 (2019): 313–20. http://dx.doi.org/10.1177/0883073819829256.

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Background/Objective: Seizure monitoring via amplitude-integrated EEG is standard of care in many neonatal intensive care units; however, conventional EEG is the gold standard for seizure detection. We compared the diagnostic yield of amplitude-integrated EEG interpreted at the bedside, amplitude-integrated EEG interpreted by an expert, and conventional EEG. Methods: Neonates requiring seizure monitoring received amplitude-integrated EEG and conventional EEG in parallel. Clinical events and amplitude-integrated EEG were interpreted at bedside. Subsequently, amplitude-integrated EEG and convent

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Abbasi, Hamid, Joanne O. Davidson, Simerdeep K. Dhillon, et al. "Deep Learning for Generalized EEG Seizure Detection after Hypoxia–Ischemia—Preclinical Validation." Bioengineering 11, no. 3 (2024): 217. http://dx.doi.org/10.3390/bioengineering11030217.

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Brain maturity and many clinical treatments such as therapeutic hypothermia (TH) can significantly influence the morphology of neonatal EEG seizures after hypoxia–ischemia (HI), and so there is a need for generalized automatic seizure identification. This study validates efficacy of advanced deep-learning pattern classifiers based on a convolutional neural network (CNN) for seizure detection after HI in fetal sheep and determines the effects of maturation and brain cooling on their accuracy. The cohorts included HI–normothermia term (n = 7), HI–hypothermia term (n = 14), sham–normothermia term

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Buttle, SG, B. Lemyre, E. Sell, et al. "P.056 Combined conventional and amplitude-integrated EEG monitoring in neonates: a prospective study." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 46, s1 (2019): S29. http://dx.doi.org/10.1017/cjn.2019.156.

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Background: Seizure monitoring via amplitude-integrated EEG (aEEG) is standard of care in many NICUs; however, conventional EEG (cEEG) is the gold standard for seizure detection. We compared the diagnostic yield of aEEG interpreted at the bedside, aEEG interpreted by an expert, and cEEG. Methods: Neonates received aEEG and cEEG in parallel. Clinical events and aEEG were interpreted at bedside and subsequently independently analyzed by experienced neonatology and neurology readers. Sensitivity and specificity of bedside aEEG as compared to expert aEEG interpretation and cEEG were evaluated. Res

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Asaduzzaman, Mohammad, Md Mizanur Rahman, and Mohammad Nadim Hasan. "Clinical Predictors of Poorly-Controlled Childhood Epilepsy: A Case-Control Study." Medicine Today 32, no. 2 (2020): 85–90. http://dx.doi.org/10.3329/medtoday.v32i2.48819.

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Introduction:The aim of the present study was to determine clinical factors associated with poorly controlled epilepsy. Materials and Methods: This retrospective study was performed from January 2007 to December 2008 at Paediatric Neurology outpatient department in Bangabandhu Sheikh Mujib Medical University, Dhaka, among the children with epilepsy of 7 months to 15 years age who had history of at least 6 months treatment with rational antiepileptic drugs daily with adequate compliance. There were two groups of patients; group 1, consisted of 50 poorly controlled epilepsy patients and gr

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Pereira, Matheus Martins, and Marcos Alves Pavione. "PERFIL DOS RECÉM NASCIDOS MONITORIZADOS POR MEIO DE ELETROENCEFALOGRAMA DE AMPLITUDE INTEGRADA EM UMA MATERNIDADE PRIVADA DO NORDESTE DO BRAZIL." Revista ft 29, no. 140 (2024): 52–53. http://dx.doi.org/10.69849/revistaft/ni10202411071352.

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Neonatal seizures are a prevalent emergency, with mortality rates of 20-40% and morbidity rates of 40-60%. Defined as motor, behavioral, or autonomic neurological changes, seizures manifest within the first 28 days of life in term neonates or up to 44 weeks corrected gestational age in preterm infants. Incidence varies between 1-5 per 1,000 live births, increasing to 10-130 per 1,000 in preterm infants. Main causes include hypoxic-ischemic encephalopathy (HIE), ischemic stroke, intracranial hemorrhage, brain malformations, metabolic disorders, infections, and hypoglycemia. The primary goal is

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Temko, A., E. Thomas, W. Marnane, G. Lightbody, and G. B. Boylan. "Performance assessment for EEG-based neonatal seizure detectors." Clinical Neurophysiology 122, no. 3 (2011): 474–82. http://dx.doi.org/10.1016/j.clinph.2010.06.035.

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AL-Naddawi, Mahjoob N., Numan N. Hameed, and Meisloon J. Kadum. "Clinical types and possible etiologies of neonatal seizures: A hospital based study." Journal of the Faculty of Medicine Baghdad 53, no. 1 (2011): 1–5. http://dx.doi.org/10.32007/jfacmedbagdad.531898.

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Background: Seizures in the neonatal period are common. They can present as focal clonic, focal tonic, myoclonic, generalized tonic and subtle seizures. They can be caused by a variety ofconditions, ranging from benign self-limited illnesses to severe life-threatening disorders.Patients and methods: A prospective study included 75 neonates with seizures in the first 28 days of life were admitted to neonatal care unit in Children Welfare Teaching Hospital from January 15th 2009 to August 15th 2009. A Full history was obtained and patients were examined by a specialist in the neonatal care unit

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Kozhanova, T. V., S. S. Zhilina, T. I. Mescheryakova, et al. "Mutation of the ALDH7A1 gene in a patient with pyridoxal phosphate-dependent neonatal epileptic encephalopathy: a clinical case." Epilepsia and paroxysmal conditions 11, no. 1 (2019): 70–78. http://dx.doi.org/10.17749/2077-8333.2019.11.1.70-78.

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The article presents a clinical case of severe infantile generalized idiopathic epilepsy with status-like seizures, muscular dystonia and developmental delay. The examination included a phenotypic analysis: the course of the perinatal period, the nature of seizures, cognitive and behavioral disorders; video electroencephalography, and brain MRI. Using the targeted exome sequencing of genes associated with epileptic encephalopathy (NGS), we detected a nucleotide heterozygous variant of the ALDH7A1 gene (previously not described). This mutation led to the appearance of a stop codon in position 8

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Edwards, David A., Hina P. Shah, Wengang Cao, Nikolaus Gravenstein, Christoph N. Seubert, and Anatoly E. Martynyuk. "Bumetanide Alleviates Epileptogenic and Neurotoxic Effects of Sevoflurane in Neonatal Rat Brain." Anesthesiology 112, no. 3 (2010): 567–75. http://dx.doi.org/10.1097/aln.0b013e3181cf9138.

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Background We tested the hypothesis that in newborn rats, sevoflurane may cause seizures, neurotoxicity, and impairment in synaptic plasticity-effects that may be diminished by the Na-K-2Cl cotransporter 1 inhibitor, bumetanide. Methods Electroencephalography, activated caspase-3, and hippocampal long-term potentiation were measured in rats exposed to 2.1% sevoflurane for 0.5-6 h at postnatal days 4-17 (P4-P17). Results Arterial blood gas samples drawn at a sevoflurane concentration of 2.1% showed no evidence of either hypoxia or hypoventilation in spontaneously breathing rats. Higher doses of

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17

Harsono, Mimily, Massroor Pourcyrous, Elliott J. Jolly, et al. "Selective head cooling during neonatal seizures prevents postictal cerebral vascular dysfunction without reducing epileptiform activity." American Journal of Physiology-Heart and Circulatory Physiology 311, no. 5 (2016): H1202—H1213. http://dx.doi.org/10.1152/ajpheart.00227.2016.

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Epileptic seizures in neonates cause cerebrovascular injury and impairment of cerebral blood flow (CBF) regulation. In the bicuculline model of seizures in newborn pigs, we tested the hypothesis that selective head cooling prevents deleterious effects of seizures on cerebral vascular functions. Preventive or therapeutic ictal head cooling was achieved by placing two head ice packs during the preictal and/or ictal states, respectively, for the ∼2-h period of seizures. Head cooling lowered the brain and core temperatures to 25.6 ± 0.3 and 33.5 ± 0.1°C, respectively. Head cooling had no anticonvu

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18

Cao, Binbin, Bingwei Peng, Yang Tian, et al. "Clinical and genetic analysis of 18 patients with <i>KCNQ2 </i>mutations from South China." Turkish Journal of Pediatrics 66, no. 2 (2024): 191–204. http://dx.doi.org/10.24953/turkjpediatr.2024.4593.

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Background. We aimed to delineate the genotype and phenotype of patients with KCNQ2 mutations from South China. Methods. Clinical manifestations and characteristics of KCNQ2 mutations of patients from South China were analyzed. Previous patients with mutations detected in this study were reviewed. Results. Eighteen epilepsy patients with KCNQ2 mutations, including seven self-limited neonatal epilepsy (SeLNE), two self-limited infantile epilepsy (SeLIE) and nine developmental and epileptic encephalopathy (DEE) were enrolled. The age of onset (p=0.006), mutation types (p=0.029), hypertonia (p=0.

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Morozova, E. A., R. R. Sergeeva, and D. V. Morozov. "Practical aspects of diagnosis and treatment of neonatal seizures." Epilepsia and paroxyzmal conditions 10, no. 4 (2019): 17–25. http://dx.doi.org/10.17749/2077-8333.2018.10.4.017-025.

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Aim– analyze the current practice of management in patients with neonatal seizures and perinatal brain disorders, and determine the ways to prevent long-term neurological complications.Materials and methods.The study group included 140 children (aged from 2 weeks to 18 months) with neonatal seizures and perinatal brain abnormalities. In these cases, the obstetric and early postnatal history was analyzed; all patients underwent video-EEG monitoring, cervical spine X-ray, neuroimaging, and a Doppler ultrasound test.Results.We found a number of reliable ante- and intra- partum predictors of neona

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Paprocka, Justyna, Magdalena Nowak, Magdalena Machnikowska-Sokołowska, Karolina Rutkowska, and Rafał Płoski. "Leukodystrophy with Macrocephaly, Refractory Epilepsy, and Severe Hyponatremia—The Neonatal Type of Alexander Disease." Genes 15, no. 3 (2024): 350. http://dx.doi.org/10.3390/genes15030350.

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Introduction: Alexander disease (AxD) is a rare neurodegenerative condition that represents the group of leukodystrophies. The disease is caused by GFAP mutation. Symptoms usually occur in the infantile age with macrocephaly, developmental deterioration, progressive quadriparesis, and seizures as the most characteristic features. In this case report, we provide a detailed clinical description of the neonatal type of AxD. Method: Next-Generation Sequencing (NGS), including a panel of 49 genes related to Early Infantile Epileptic Encephalopathy (EIEE), was carried out, and then Whole Exome Seque

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De Vos, M., W. Deburchgraeve, P. J. Cherian, et al. "PW7-3 Automated neonatal seizure detectors 1: heuristic approach and experience." Clinical Neurophysiology 121 (October 2010): S90. http://dx.doi.org/10.1016/s1388-2457(10)60381-1.

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Toet, Mona C., Floris Groenendaal, Damjan Osredkar, Alexander C. van Huffelen, and Linda S. de Vries. "Postneonatal epilepsy following amplitude-integrated EEG-detected neonatal seizures." Pediatric Neurology 32, no. 4 (2005): 241–47. http://dx.doi.org/10.1016/j.pediatrneurol.2004.11.005.

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Vanhatalo, Sampsa. "Development of neonatal seizure detectors: An elusive target and stretching measuring tapes." Clinical Neurophysiology 122, no. 3 (2011): 435–37. http://dx.doi.org/10.1016/j.clinph.2010.07.021.

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Stevenson, N. J. "PW7-4 Automated neonatal seizure detectors 2: systematic approach and clinical application." Clinical Neurophysiology 121 (October 2010): S90—S91. http://dx.doi.org/10.1016/s1388-2457(10)60382-3.

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Safarova, A. G. "CHARACTERISTICS OF GLYCEMIC AND MINERAL HEMOSTASIS WHILE NEONATAL CONVULSIONS." National Journal of Neurology 1, no. 19 (2019): 58–62. http://dx.doi.org/10.61788/njn.v1i19.06.

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This article is devoted to the disbalance of glycemic and mineral hemostasis in the etiopathogenetic mechanism of neonatal seizures. The purpose of the article: to assess the state of glycemic and mineral hemostasis in patients with neonatal convulsions. Materials and methods. 73 patients with neonatal convulsions were under observation. A blood glucose, sodium, potassium, magnesium and calcium content were investigated in all patients. Results. Among patients with neonatal convulsions hypoglycemia was detected 34.3±5.6%, hypocalcemia – 34.3±5.6%, hypomagnesaemia – 9.6±3.1%, combination of hyp

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van Rooij, L. G. M., M. C. Toet, A. C. van Huffelen, et al. "Effect of Treatment of Subclinical Neonatal Seizures Detected With aEEG: Randomized, Controlled Trial." PEDIATRICS 125, no. 2 (2010): e358-e366. http://dx.doi.org/10.1542/peds.2009-0136.

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Xu, Xiongfei, Zhongzhuang Wang, Quan Li, et al. "Endothelial Nitric Oxide Synthase Expression Is Progressively Increased in Primary Cerebral Microvascular Endothelial Cells During Hyperbaric Oxygen Exposure." Oxidative Medicine and Cellular Longevity 2, no. 1 (2009): 7–13. http://dx.doi.org/10.4161/oxim.2.1.7697.

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Exposure to hyperbaric oxygen (HBO) can lead to seizures. Many studies have demonstrated that there exist a very close relationship between the alteration of cerebral blood flow (CBF) and the onset of seizures. Nitric oxide (NO) may play a key role in the change of CBF during exposure, and modulation of endothelial nitric oxide synthase (eNOS)-derived NO by HBO is responsible for early vasoconstriction, whereas late HBO-induced vasodilation depends upon a large amount of NO from both eNOS and neuronal nitric oxide synthase (nNOS). To investigate the effect of HBO on the activity and expression

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Deeg, Karl-Heinz. "Sonographic and Doppler Sonographic Diagnosis of Neonatal Ischemic Stroke." Ultraschall in der Medizin - European Journal of Ultrasound 38, no. 04 (2017): 360–76. http://dx.doi.org/10.1055/s-0043-114409.

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AbstractChildren are particularly at risk for stroke in the neonatal period. 1/3 of all strokes in children occur during the perinatal period. The incidence of perinatal stroke is 1:4000. A differentiation is made between ischemic stroke and hemorrhagic stroke. Ischemic strokes are caused by arterial occlusion due to thrombosis or embolism. As a result of the nonspecific clinical symptoms in this age group, diagnosis is usually made too late. The only relatively specific symptom is focal cerebral seizure during the first week of life. Therefore, stroke should be ruled out by diagnostic imaging

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Deeg, Karl-Heinz. "Duplex Sonographic Diagnosis of Perinatal Hemorrhagic Stroke." Ultraschall in der Medizin - European Journal of Ultrasound 38, no. 05 (2017): 484–98. http://dx.doi.org/10.1055/s-0043-115107.

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AbstractChildren are particularly at risk for stroke in the neonatal period. Neonatal hemorrhagic stroke is rarer than ischemic stroke. The incidence is 40.7/100 000 live births. Hemorrhagic stroke is caused by a disruption in venous drainage usually due to local thrombosis. As a result of the nonspecific clinical symptoms in this age group, diagnosis is usually made too late. The only relatively specific symptom is a cerebral seizure during the first week of life. Therefore, stroke should be ruled out by diagnostic imaging in the case of any seizure in the first days of life. The diagnostic m

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Freitas, Alessandra, Erasmo B. Casella, Marcelo Valente, Carlos A. Buchpiguel, and Kette D. R. Valente. "Neonatal seizures: the overlap between diagnosis of metabolic disorders and structural abnormalities. Case report." Arquivos de Neuro-Psiquiatria 61, no. 2B (2003): 478–81. http://dx.doi.org/10.1590/s0004-282x2003000300029.

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Inborn metabolic errors (IME) and cortical developmental malformations are uncommon etiologies of neonatal seizures, however they may represent treatable causes of refractory epilepsy and for this reason must be considered as possible etiological factors. This case report aims to demonstrate the importance of neuroimaging studies in one patient with neonatal seizures, even when there are clues pointing to a metabolic disorder. CASE REPORT: A previously healthy 14 day-old child started presenting reiterated focal motor seizures (FMS) which evolved to status epilepticus. Exams showed high serum

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Zavadenko, A. N., M. I. Medvedev, M. G. Degtyareva, S. O. Rogatkin, and N. N. Zavadenko. "Etiologies of neonatal seizures in infants of different gestational age." Epilepsia and paroxyzmal conditions 10, no. 3 (2018): 19–30. http://dx.doi.org/10.17749/2077-8333.2018.10.3.019-030.

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Aim:To determine main etiologies and clinical features of neonatal seizures (NS) in groups of newborns of different gestational age (GA).Materials and Methods. Main etiologies of NS were evaluated in 165 newborns divided into four groups: I – 84 early preterm newborns with GA of 28 weeks or less, II – 52 newborns with 29-32 weeks GA, III – 12 newborns with 33-36 weeks GA, and IV – 17 term infants with GA between 37 and 41 wks.Results. In the above 165 infants, the following causes of NS were found: perinatal hypoxia-ischemia – 72.1% of cases, grade III-IV intracranial hemorrhage – 6.1%, congen

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Bertram, Edward H. "How Epilepsy Changes Sodium Channels." Epilepsy Currents 3, no. 2 (2003): 72. http://dx.doi.org/10.1111/j.1535-7597.2003.03215.x.

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Induction of Neonatal Sodium Channel II and III α-Isoform mRNAs in Neurons and Microglia After Status Epilepticus in the Rat Hippocampus Aronica E, Yankaya B, Troost D, van Vliet EA, Lopes da Silva FH, Gorter JA Eur J Neurosci 2001;13(6):1261 Sodium channels (NaChs) regulate neuronal excitability in both physiologic and pathological conditions, including epilepsy, and are therefore an important target for antiepileptic drugs (AEDs). In the present study, we examined the distribution of messenger RNAs (mRNAs) encoding neonatal NaChs II and III α-isoforms in control rat hippocampus and after ele

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Elzeblawy Hassan, Hanan. "Fetal and neonatal complications of pregnancy induced hypertension." American Research Journal of Public Health 3, no. 1 (2020): 1–3. http://dx.doi.org/10.21694/2639-3042.20003.

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Most pregnancy leаd to а successful outcome without complicаtionHowever, many factors can interfere with the normal process of pregnancy and may threat to the health of the mother or the development of the fetus. These fаctors can be detected at the beginning of pregnancy by reviewing the dаnger signs that may indicate complication. Pre-eclаmpsiа (PE) is а multi-system disorder of the mother that affects the fetus because of utero-plаcental insufficiency. In consequence, these children are at risk for intrа-uterine growth restriction and may be delivered premаturely. They may also suffer from

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Sharpe, Cynthia, Suzanne L. Davis, Gail E. Reiner, et al. "Assessing the Feasibility of Providing a Real-Time Response to Seizures Detected With Continuous Long-Term Neonatal Electroencephalography Monitoring." Journal of Clinical Neurophysiology 36, no. 1 (2019): 9–13. http://dx.doi.org/10.1097/wnp.0000000000000525.

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Che, Yuanyuan, Jianmin Zhong, Yong Chen, et al. "A newborn with convulsions 12 days after birth was misdiagnosed as neonatal intracranial hemorrhage: Case report." Medicine 102, no. 52 (2023): e36675. http://dx.doi.org/10.1097/md.0000000000036675.

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Introduction: Cases with early diagnosis of neonatal tuberous sclerosis syndrome (TSC) are relatively seldom seen, and misdiagnosis of intracranial hemorrhage is even more rare. We retrospectively analyzed the clinical data of a case of neonatal tuberous sclerosis with atypical early symptoms and misdiagnosed as more common intracranial hemorrhage of the newborn. Patient concerns: The child was female and had no obvious cause of convulsion 12 days after birth. The local hospital was initially diagnosed as “neonatal intracranial hemorrhage, congenital heart disease,” and still had convulsions a

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Hawisa, Karima T., and Nehad Gabassa. "Comparative study between intermittent auscultation and cardiotocogram in low risk group during labour in Libya." Libyan Journal of Medical Research 8, no. 1 (2014): 8–13. http://dx.doi.org/10.54361/ljmr.v8i1.02.

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The goal of fetal heart rate monitoring has been early identification of the fetus at risk for hypoxic insult. The aim of this study is to establish the relation between FHR monitoring (CTG, intermittent auscultation) and fetal outcome and mode of delivery. It is prospective observational comparative study carried out in Zawia hospital maternity word. Study population consists of 200 women in labor having the criteria of low risk group included singleton pregnancies between 37 - 40 weeks gestation, half of them monitored by intermittent auscultation and the other half by CTG. In this study, 20

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Vasiljevic, Brankica, Svjetlana Maglajlic-Djukic, and Miroslava Gojnic. "The prognostic value of amplitude-integrated electroencephalography in neonates with hypoxic-ischemic encephalopathy." Vojnosanitetski pregled 69, no. 6 (2012): 492–99. http://dx.doi.org/10.2298/vsp1206492v.

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Background/Aim. Diagnosis of perinatal hypoxic-ischemic encephalopathy (HIE) and early prediction neurological outcome is important and difficult. The aim of this study was to determine the prognostic value of amplitude integrated electroencephalography (aEEG) for abnormal neurodevelopment outcome in a neonate with HIE. Methods. A total of 90 neonates > 32 gestational age (GA) with HIE were enrolled prospectively. All neonates with HIE were categorized into three grades according to the Sarnat and Sarnat clinical scoring system (mild HIE, moderate HIE and severe HIE). aEEG traces were recor

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Seubert, Christoph N., Wanting Zhu, Christopher Pavlinec, Nikolaus Gravenstein, and Anatoly E. Martynyuk. "Developmental Effects of Neonatal Isoflurane and Sevoflurane Exposure in Rats." Anesthesiology 119, no. 2 (2013): 358–64. http://dx.doi.org/10.1097/aln.0b013e318291c04e.

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Abstract Background: The general anesthetics, isoflurane and sevoflurane, cause developmental abnormalities in neonatal animal models via incompletely understood mechanisms. Despite many common molecular targets, isoflurane and sevoflurane exhibit substantial differences in their actions. The authors sought to determine whether these differences can also be detected at the level of neurodevelopmental effects. Methods: Postnatal rats, 4–6 days old, were exposed to 1.2% isoflurane or 2.1% sevoflurane for 1–6 h and studied for immediate and delayed effects. Results: Isoflurane exposure was associ

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Kapoor, S., M. Nemcovic, J. Folbergrova, et al. "N-glycans Profiling in Pilocarpine Induced Status Epilepticus in Immature Rats." European Pharmaceutical Journal 69, no. 2 (2022): 1–4. http://dx.doi.org/10.2478/afpuc-2022-0011.

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Abstract Status epilepticus (SE) is a common neurological emergency in children and a well-known epileptogenic insult. Neonates are extremely susceptible to seizures in the neonatal period due to the higher vulnerability. Neonatal SE is associated with significant mortality and morbidity. There is an evident need for attention on neonatal SE in research due to the incredibly limited diagnostic and treatment options in current neonatology, and its serious long-term consequences. The aim of the present study was to characterize the glycoprofiles in the pilocarpine-induced SE model in immature ra

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Qureshi, Umar Amin, Abdus Sami Bhat, Muzaffar Jan, and Uruj Qureshi. "Late Onset Hypocalcemic Seizures in Formula-Fed, Vitamin D Deficient Babies: Revisited." Journal of Neonatology 34, no. 1-2 (2020): 15–18. http://dx.doi.org/10.1177/0973217920927903.

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Purpose: Late onset neonatal hypocalcemia (LNH) is defined as hypocalcemia detected after day 3 of life. Its occurrence in babies fed with cow’s milk is well understood. Since the advent of modern-day formulas, the incidence has however decreased. Methods: A prospective descriptive study (January 2017 to December 2017) of LNH seizures in neonates was conducted. LNH was defined as the total serum calcium of less than 7 mg/dL in preterm or less than 8 mg/dL in term newborns after 72 h of life. Results: 14 neonates were presented with myoclonic and focal seizures due to late hypocalcemia. All wer

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Patil, Madhoosudan, Brock Matter, Yogendra Raol, David Bourne, Ryan Kelley, and Uday Kompella. "Brain Distribution and Metabolism of Flupirtine, a Nonopioid Analgesic Drug with Antiseizure Effects, in Neonatal Rats." Pharmaceutics 10, no. 4 (2018): 281. http://dx.doi.org/10.3390/pharmaceutics10040281.

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Flupirtine, a nonopioid analgesic drug, is effective in treating neonatal seizures. However, its brain delivery and pharmacokinetics are unknown in neonatal mammals. The purpose of this study was to determine the pharmacokinetics of flupirtine and the formation of its active metabolite D-13223 in various tissues such as brain in neonate animals. On postnatal day 7, rat pups received 25 mg/kg of flupirtine intraperitoneally. Liver; heart; kidney; lung; spleen; retina; serum; and brain regions hippocampus, cortex, and the remaining brain (devoid of cerebellum) were harvested up to 24-h postdosin

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Polise, Olivia, and Desi Newberry. "The Use of Cerebral Near-Infrared Spectroscopy in Neonatal Hypoxic-Ischemic Encephalopathy." Advances in Neonatal Care 23, no. 6 (2023): 547–54. http://dx.doi.org/10.1097/anc.0000000000001114.

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Background: Cerebral near-infrared spectroscopy (cNIRS) is a noninvasive technology used to trend cerebral perfusion at the bedside. cNIRS has potential as a valuable tool in the evaluation of infants with suspected hypoxic-ischemic encephalopathy (HIE). Trending cerebral perfusion with cNIRS can provide information regarding cerebral metabolism as HIE is evolving, which may offer insight into the extent of brain injury. Purpose: The purpose of this systematic review is to investigate the use of cNIRS as a neurocritical tool in the management of neonatal HIE by evaluating its ability to detect

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Kowalczyk, Emilia, Sylwia Koziej, Martyna Niemczuk, Adrianna Jasiuk, and Mateusz Wiekiera. "Congenital toxoplasmosis: potential outcomes and therapeutic challenges - a complex case report of the newborn with treatment-resistant manifestations." Journal of Education, Health and Sport 54 (January 21, 2024): 187–99. http://dx.doi.org/10.12775/jehs.2024.54.014.

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Introduction and purpose Toxoplasmosis, a prevalent parasitic infection caused by Toxoplasma gondii, impacts approximately one-third of the global population. Among congenital infections, Congenital Toxoplasmosis (CT) ranks second only to CMV infection in neonates. The severity of fetal and neonatal clinical manifestations depends on factors such as gestational age during infection, parasite load, infectious strain virulence, and maternal immune status. The organogenesis stage in the second trimester is identified as the critical period (10th-24th gestational weeks). Fetal CT may present with

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Lu, Yang, Stephan Waltz, Katja Stenzel, Hiltrud Muhle, and Ulrich Stephani. "Photosensitivity in epileptic syndromes of childhood and adolescence." Epileptic Disorders 10, no. 2 (2008): 136–43. http://dx.doi.org/10.1684/epd.2008.0183.

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ABSTRACT Purpose Photosensitivity, a reaction of the brain to external photic stimulation, can be graded from 1 to 4, and is most frequently seen in the first decades of life. This study investigated photosensitivity in children with epilepsy. Methods A retrospective study performed in the neuropaediatric department of the largest paediatric hospital in Kiel, treating patients at all medical care levels. The clinical data and EEG records of 566 patients with the most common epileptic syndromes were analyzed, in particular regarding photosensitivity. Their EEGs included application of intermitt

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V. V., Lakshmi Aparna Devi, Chapay Soren, M. Umadevi, and R. Pradeep. "Incidence of meningitis in term neonates with sepsis and antibiotic sensitivity pattern: an observational study." International Journal of Contemporary Pediatrics 7, no. 1 (2019): 99. http://dx.doi.org/10.18203/2349-3291.ijcp20195734.

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Background: To find out the incidence of meningitis in neonatal sepsis and antibiotic sensitivity pattern in term neonates.Methods: This prospective observational cohort study was done in a tertiary care hospital located in rural South India for a period of 2 years. Blood culture and lumbar puncture were performed for all term babies with clinically suspected sepsis. Growth, if detected was followed by antibiotic sensitivity testing.Results: Of a total of 50 neonates investigated with blood culture, 32(64%) were found to be culture positive for neonatal septicemia, 16 were diagnosed to have me

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Jiang, Liang-Liang, Shao-Hua Bi, Jing Yu, Feng-Xia Zhao, Maggie Teng, and Ru-Jeng Teng. "Severe hemolytic disease of the newborn caused by JKb antibody: Two case reports and literature review." Medicine 102, no. 30 (2023): e34390. http://dx.doi.org/10.1097/md.0000000000034390.

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Background: JKb antibody rarely causes severe hemolytic disease in the newborn except in 1 case, required blood exchange transfusion but later died of intractable seizure and renal failure. Here we describe 2 cases of JKb-induced severe neonatal jaundice requiring blood exchange transfusion with good neurological outcome. Case presentation: Two female Chinese, ethnic Han, term infants with severe jaundice were transferred to us at the age of 5- and 4-day with a total bilirubin of 30.9 and 25.9 mg/dL while reticulocyte counts were 3.2% and 2.2%, respectively. Both infants were not the firstborn

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Sousa, Tainã Maria Alves de, Vinicius Siessere Gugelmin, Geraldo Magela Fernandes, Carlos Nogueira Aucélio, Karina Nascimento Costa, and Rosana Maria Tristão. "Comparison of conventional, amplitude-integrated and geodesic sensor net EEG used in premature neonates: a systematic review." Arquivos de Neuro-Psiquiatria 77, no. 4 (2019): 260–67. http://dx.doi.org/10.1590/0004-282x20190030.

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ABSTRACT The use of methods to evaluate cortical activity in neonates has great importance in modern medicine, as it allows the observation and evaluation of several clinical aspects, which guarantees that the health team has knowledge about possible intervention measures that may be necessary in the treatment of newborns. Objective: This systematic review aimed to compare the main technologies available for the evaluation of brain functions in neonates, among them: the conventional electroencephalogram (EEG), the amplitude-integrated electroencephalogram (aEEG) and the geodesic sensor net EEG

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Odenwald, Brigitte, Uta Nennstiel-Ratzel, Helmuth-Günther Dörr, Heinrich Schmidt, Manfred Wildner, and Walter Bonfig. "Children with classic congenital adrenal hyperplasia experience salt loss and hypoglycemia: evaluation of adrenal crises during the first 6 years of life." European Journal of Endocrinology 174, no. 2 (2016): 177–86. http://dx.doi.org/10.1530/eje-15-0775.

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ObjectiveTo evaluate adrenal crises after the start of treatment up to the age of 6 years in children with classic congenital adrenal hyperplasia (CAH).DesignAnalysis of data extracted from a population-based prospective long-term follow-up study of children detected in neonatal screening.MethodsData of 102 Bavarian children with classic CAH due to 21-hydroxylase deficiency were analyzed, using parental questionnaires and medical reports. Parent-reported hospital admissions of children diagnosed with acute health impairment were included in the analysis if salt loss (hyponatremia) or hypoglyce

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Khani, Soghra, Mina Barzegari, Zahra Esmaeilizadeh, et al. "The treatment and clinical follow-up outcome in Iranian patients with tetrahydrobiopterin deficiency." Journal of Pediatric Endocrinology and Metabolism 34, no. 9 (2021): 1157–67. http://dx.doi.org/10.1515/jpem-2021-0155.

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Abstract Objectives This study aimed to evaluate the biochemical factors, genetic mutations, outcome of treatment, and clinical follow-up data of Iranian patients with tetrahydrobiopterin (BH4) deficiency from April/2016 to March/2020. Methods Forty-seven BH4 deficiency patients were included in the study and underwent biochemical and genetic analyses. The clinical outcomes of the patients were evaluated after long-term treatment. Results Out of the 47 (25 females and 22 males) BH4 deficiency patients enrolled in the study, 23 were Dihydropteridine reductase (DHPR) deficient patients, 23 were

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Dipak, Niraj Kumar, and Nadia Shagufta. "Malignant Infantile Osteopetrosis: A Rare Cause of Refractory Hypocalcemia." Indian Pediatrics Case Reports 3, no. 4 (2023): 229–33. http://dx.doi.org/10.4103/ipcares.ipcares_70_23.

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Background: Infantile malignant osteopetrosis (IMO) is a rare autosomal recessive disease characterized by a higher bone density in bone marrow caused by the dysfunction of bone resorption. Clinical Description: A 2-month-old baby boy presented with features of lower respiratory tract infection, along with a swollen right upper arm due to fracture of humerus, along with signs of bicytopenia and hepatosplenomegaly. He had a history of hypocalcemic seizures at 8th day of life. Management and Outcome: Current hospitalization revealed refractory hypocalcemia and hypophosphatemia with normal to inc

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