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Journal articles on the topic 'Neoplasm DNA'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 July 2025

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1

Clemo, F. A. S., D. B. DeNicola, W. W. Carlton, W. B. Morrison, and E. Walker. "Flow Cytometric DNA Ploidy Analysis in Canine Transitional Cell Carcinoma of Urinary Bladders." Veterinary Pathology 31, no. 2 (1994): 207–15. http://dx.doi.org/10.1177/030098589403100208.

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Flow cytometric analysis of DNA ploidy was performed on 51 formalin-fixed, paraffin-embedded samples of canine transitional cell carcinoma of the urinary bladder. The DNA ploidy data obtained were compared to several clinicopathologic features. In addition, the DNA ploidy of 15 hyperplastic/inflamed and 8 normal canine urinary bladders was measured. Forty-three of the 51 neoplastic samples had interpretable DNA histograms. DNA aneuploidy was found in 34/43 (79%) of the transitional cell carcinoma samples. Of the 34 aneuploid neoplasms, 16 (47%) were hyperdiploid, 17 (50%) were tetraploid, and

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Tekin, Burak, Sounak Gupta, and Lori A. Erickson. "Sebaceous Neoplasm With Defective DNA Mismatch Repair." Mayo Clinic Proceedings 99, no. 5 (2024): 846–48. http://dx.doi.org/10.1016/j.mayocp.2024.02.021.

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Van Treeck, Benjamin J., Mira Lotfalla, Thomas W. Czeczok, et al. "Molecular and Immunohistochemical Analysis of Mucinous Cystic Neoplasm of the Liver." American Journal of Clinical Pathology 154, no. 6 (2020): 837–47. http://dx.doi.org/10.1093/ajcp/aqaa115.

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Abstract Objectives Mucinous cystic neoplasm of the liver is characterized by neoplastic mucinous and/or biliary epithelium surrounded by ovarian-type stroma. Immunohistochemical studies have shown that the ovarian-type stroma expresses estrogen receptor, suggesting potential hormonal responsiveness. The molecular biology of mucinous cystic neoplasm of the liver remains poorly studied. Methods Transcriptome sequencing and immunohistochemistry were performed on a series of mucinous cystic neoplasms. Results Mucinous cystic neoplasm of the liver exhibited significantly increased RNA expression o

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Wibawa, Bagus Wira, Resti Hardianti Lestari, and Dimas Seto Prasetyo. "Perbandingan HPV DNA Test Hybrid Capture dan Pap Smear untuk Diagnosis Dini Karsinoma Serviks." eJournal Kedokteran Indonesia 12, no. 2 (2024): 187. https://doi.org/10.23886/ejki.12.643.187.

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Kanker serviks adalah kanker paling sering terjadi keempat pada wanita di seluruh dunia. Standar baku yang biasa dipakai untuk diagnosis dini adalah Pap smear. Sensitivitas yang rendah, tingkat negatif palsu yang tinggi, dan variabilitas interobserver menjadi kendala dari Pap smear. Saat ini telah dikembangkan pemeriksaan HPV DNA (hybrid capture) sebagai metode alternatif diagnosis dini karsinoma serviks. Laporan kasus berdasarkan bukti ini bertujuan untuk mengetahui perbandingan akurasi pemeriksaan HPV DNA (hybrid capture) dengan pemeriksaan Pap smear untuk diagnosis dini karsinoma serviks. T

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Hoermann, Gregor. "Clinical Significance of Clonal Hematopoiesis of Indeterminate Potential in Hematology and Cardiovascular Disease." Diagnostics 12, no. 7 (2022): 1613. http://dx.doi.org/10.3390/diagnostics12071613.

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Liquid profiling uses circulating tumor DNA (ctDNA) for minimal invasive tumor mutational profiling from peripheral blood. The presence of somatic mutations in peripheral blood cells without further evidence of a hematologic neoplasm defines clonal hematopoiesis of indeterminate potential (CHIP). CHIP-mutations can be found in the cell-free DNA (cfDNA) of plasma, are a potential cause of false positive results in liquid profiling, and thus limit its usage in screening settings. Various strategies are in place to mitigate the effect of CHIP on the performance of ctDNA assays, but the detection

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Chen, Tsai-Yun, Jiann-Shiuh Chen, Wu-Chou Su, Ming-Shiuan Wu, and Chao-Jung Tsao. "Expression of DNA repair gene Ku80 in lymphoid neoplasm." European Journal of Haematology 74, no. 6 (2005): 481–88. http://dx.doi.org/10.1111/j.1600-0609.2005.00428.x.

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7

Curti, P., P. Beltrami, C. Tallarigo, G. Malossini, A. D'Amico, and D. Schiavone. "Flow Cytometry Role of DNA Analysis." Urologia Journal 61, no. 3 (1994): 226–28. http://dx.doi.org/10.1177/039156039406100313.

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We analyzed the results obtained by flow cytometry DNA analysis in prostatic cancer. We considered the diagnostic role of this investigation and the prognostic value observed from correlating the DNA analysis with usual diagnostic and prognostic factors such as staging, grading, PSA, size, etc. Results in literature suggest that further studies are necessary to explain both the biological and cytometrical heterogeneous aspects of this neoplasm.

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Wang, Xinhua, Yu Chang, Dandan Zhu, et al. "Integrating Circulating Tumor DNA Features and Plasma Protein Markers to Detected Early Lymphoid Neoplasm." Blood 138, Supplement 1 (2021): 4489. http://dx.doi.org/10.1182/blood-2021-145683.

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Abstract Introduction The disease burden of lymphoid neoplasm has been rising in China over the last decade. But most patients manifest with advanced stage disease at initial diagnosis, and the prognosis is poor with a 5-year survival rate of 38.3%. Here we reported a novel multivariate cancer risk score (CRS) model which is used to detect early lymphoid neoplasm from the peripheral blood. It incorporates three cancer hallmarks, copy number aberrations (CNA) and fragment size (FS) via shallow whole genome sequencing (sWGS) from cell-free DNA (cfDNA), and a panel of seven tumor protein markers

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Zaghdoudi, Asma, Olfa Blel, Mohamed Habib Hedhiri, et al. "Case Report: Periocular Malignant Neoplasm." F1000Research 14 (July 7, 2025): 666. https://doi.org/10.12688/f1000research.164464.1.

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Introduction Periocular tissues are exposed to sunlight ultraviolet rays. Unreparable DNA damage may also araise. Thus, uncontrolled tumor proliferation may occur. Surgical excision remains a treatment associated with adjuvant management. Observation A 57-year male presented with optic correction. He was classified as skin prototype III. An ophthalmological examination revealed an ulcerative lower eyelid lesion. He underwent a biopsy with histological analysis confirmed the presence of malignant basaloid tumor cells. Complete excision was performed with 3 mm surgical margins and associated wit

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10

Pronier, Elodie, Carole Almire, Hayat Mokrani, et al. "Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors." Blood 118, no. 9 (2011): 2551–55. http://dx.doi.org/10.1182/blood-2010-12-324707.

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Abstract TET2 converts 5-methylcytosine to 5-hydroxymethylcytosine (5-hmC) in DNA and is frequently mutated in myeloid malignancies, including myeloproliferative neoplasms. Here we show that the level of 5-hmC is decreased in granulocyte DNA from myeloproliferative neoplasm patients with TET2 mutations compared with granulocyte DNA from healthy patients. Inhibition of TET2 by RNA interference decreases 5-hmC levels in both human leukemia cell lines and cord blood CD34+ cells. These results confirm the enzymatic function of TET2 in human hematopoietic cells. Knockdown of TET2 in cord blood CD34

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Maldonado-Rodríguez, Erika, Marisa Hernández-Barrales, Adrián Reyes-López, et al. "Presence of Human Papillomavirus DNA in Malignant Neoplasia and Non-Malignant Breast Disease." Current Issues in Molecular Biology 44, no. 8 (2022): 3648–65. http://dx.doi.org/10.3390/cimb44080250.

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Breast cancer is the leading cause of cancer death among women worldwide. Multiple extrinsic and intrinsic factors are associated with this disease’s development. Various research groups worldwide have reported the presence of human papillomavirus (HPV) DNA in samples of malignant breast tumors. Although its role in mammary carcinogenesis is not fully understood, it is known that the HPV genome, once inserted into host cells, has oncogenic capabilities. The present study aimed to detect the presence of HPV DNA in 116 breast tissue biopsies and classify them according to their histology. It was

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Grady, W. M. "Epigenetic events in the colorectum and in colon cancer." Biochemical Society Transactions 33, no. 4 (2005): 684–88. http://dx.doi.org/10.1042/bst0330684.

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Colon cancers arise from benign neoplasms and evolve into adenocarcinomas through a stepwise histological progression sequence, proceeding from either adenomas or hyperplastic polyps/serrated adenomas. Genetic alterations have been associated with specific steps in this polyp–adenocarcinoma sequence and are believed to drive the histological progression of colon cancer. Recently, epigenetic alterations, which include CGI (CpG island) DNA methylation, have been shown to occur in colon polyps and colon cancer. The aberrant methylation of genes appears to co-operate with the genetic alterations t

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Witte, Hanno M., Axel Künstner, Julian Schwarting, et al. "Genome-Wide DNA Methylation Profiling in Blastic Plasmacytoid Dendritic Cell Neoplasm." Blood 140, Supplement 1 (2022): 11496–97. http://dx.doi.org/10.1182/blood-2022-162212.

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Gulley, Margaret L., and Weihua Tang. "Using Epstein-Barr Viral Load Assays To Diagnose, Monitor, and Prevent Posttransplant Lymphoproliferative Disorder." Clinical Microbiology Reviews 23, no. 2 (2010): 350–66. http://dx.doi.org/10.1128/cmr.00006-09.

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SUMMARYEpstein-Barr virus (EBV) DNA measurement is being incorporated into routine medical practice to help diagnose, monitor, and predict posttransplant lymphoproliferative disorder (PTLD) in immunocompromised graft recipients. PTLD is an aggressive neoplasm that almost always harbors EBV DNA within the neoplastic lymphocytes, and it is often fatal if not recognized and treated promptly. Validated protocols, commercial reagents, and automated instruments facilitate implementation of EBV load assays by real-time PCR. When applied to either whole blood or plasma, EBV DNA levels reflect clinical

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Haferlach, Claudia, Constance Baer, Stephan Hutter, et al. "Primary and Secondary Hematological Neoplasms - Are They Related?" Blood 134, Supplement_1 (2019): 1702. http://dx.doi.org/10.1182/blood-2019-126585.

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Background: The pathogenesis of secondary hematological neoplasms occurring after a primary hematological neoplasm and the relationship between both is still unclear. We set up this study in order to evaluate whether both diseases share genomic alterations. Patients and Methods: We selected 25 patients who were diagnosed with a first hematological neoplasm (FHN) (CLL: n=14, other mature B cell neoplasm: n=6, AML: n=4, CML: n=1) and in median 48 months later (range: 16-119) with a second hematological neoplasm (SHN) (t-MDS: n= 21; t-AML: n=1, CMML: n=1; t-MPN: n=1, t-MDS/MPN: n=1). In 9 cases b

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Raj, Mukut, Manu Priya, Hemant Kumar Singh, and Suryakanta Swain. "Cancer death scenario: A brief concept on cancer related deaths." Indian Journal of Pharmacy and Pharmacology 10, no. 4 (2024): 246–52. http://dx.doi.org/10.18231/j.ijpp.2023.043.

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A mass of aberrant tissue that has grown as a result of excessive, autonomous, and uncontrolled cell proliferation is known as a cancer, neoplasm, or tumour. The loss of the cell's regulatory system and an aberrant chromosome or DNA mutation are both contributing factors to this condition. Neoplasm refers to new growth, and neoplasia refers to the process of cell proliferation. Oncology, which derives from the Greek words oncos, which means tumour, and logos, which means study, is the area of medicine that deals with the thorough examination of a neoplasm (tumour), as well as its growth, diagn

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Latha, Madhavi. "Epidemiological and Prospective Studies of Prostate Cancer." Clinical and Medical Research and Studies 3, no. 1 (2024): 1–2. https://doi.org/10.59468/2836-8525/039.

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Defects in DNA damage-response and in DNA repair often cause an increase in cancer incidence. Roles of the DNA repair are associated with modulation of hormone signaling pathway. Molecular basis for the progression of prostate cancer which is the most common neoplasm in male population remains an important subject in management of the male cancer. In addition, the molecular mechanisms by which pathogenesis may affect the prostate cancer are poorly elucidated.

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Weinerman, David J., Rashid Z. Syed, Isaac Galandauer, and Shireen A. Pais. "Mo1217 Does Fluid DNA Analysis Change the Management of Pancreatic Cystic Neoplasm?" Gastrointestinal Endoscopy 75, no. 4 (2012): AB354. http://dx.doi.org/10.1016/j.gie.2012.03.923.

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Viana, MA, RTG Oliveira, MB Costa, et al. "HYPERMETHYLATION OF DNA REPAIR GENES IS LINKED TO PROGNOSIS OF MYELODYSPLASTIC NEOPLASM." Hematology, Transfusion and Cell Therapy 45 (October 2023): S444. http://dx.doi.org/10.1016/j.htct.2023.09.829.

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Shepro, David, and Michael Miller. "Gemcitabine in Blastic Plasmacytoid Dendritic Cell Neoplasm (CD4+CD56+ hematodermic neoplasm)." Blood 124, no. 21 (2014): 5457. http://dx.doi.org/10.1182/blood.v124.21.5457.5457.

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Abstract Once thought to be a natural killer cell lymphoma, blastic plasmacytoid dendritic cell neoplasm, also termed CD4+CD56+ hematodermic neoplasm, is a rare clinical entity which derives from plasmacytoid dendritic cells. Cutaneous predominant (with better prognosis) and non-cutaneous subtypes (often accompanied by mediastinal involvement and a poorer prognosis) have been described. Many patients are treated with CHOP-like regimens, but the prognosis remains poor. Patients presenting with only skin lesions (median survival 21 months) had a better prognosis than patients presenting with bot

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21

Higgs, Martin R., Sofia Browne, Ryan Collinson, et al. "Mutational Analysis of the Genome Stability Factor BOD1L1 in Myeloproliferative Neoplasm." Blood 142, Supplement 1 (2023): 5677. http://dx.doi.org/10.1182/blood-2023-179125.

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The myeloproliferative neoplasms (MPN) are a group of clonal hematopoietic stem cell disorders that include essential thrombocythemia (ET), polycythemia vera (PV) and myelofibrosis (MF) which arise from somatic mutations in JAK2, MPL or CALR, but which can evolve to acute myeloid leukemia (AML) by the acquisition of additional somatic mutations. To investigate the contribution that mutations might make to the pathogenesis or clinical course of MPNs, 261 genes recurrently mutated in myeloid malignancies were sequenced in DNA from germline and blood samples from patients with AML, ET and MF enro

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22

Dharajiya, Nilesh G., Daniel S. Grosu, Daniel H. Farkas, et al. "Incidental Detection of Maternal Neoplasia in Noninvasive Prenatal Testing." Clinical Chemistry 64, no. 2 (2018): 329–35. http://dx.doi.org/10.1373/clinchem.2017.277517.

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Abstract BACKGROUND Noninvasive prenatal testing (NIPT) uses cell-free DNA (cfDNA) as an analyte to detect copy-number alterations in the fetal genome. Because maternal and fetal cfDNA contributions are comingled, changes in the maternal genome can manifest as abnormal NIPT results. Circulating tumor DNA (ctDNA) present in cases of maternal neoplasia has the potential to distort the NIPT readout to a degree that prevents interpretation, resulting in a nonreportable test result for fetal aneuploidy. METHODS NIPT cases that showed a distortion from normal euploid genomic representation were comm

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de Zoeten, Edwin, Victoria Carr-Brendel, Dubravka Markovic, Joyce Taylor-Papadimitriou, and Edward P. Cohen. "Treatment of Breast Cancer with Fibroblasts Transfected with DNA from Breast Cancer Cells." Journal of Immunology 162, no. 11 (1999): 6934–41. http://dx.doi.org/10.4049/jimmunol.162.11.6934.

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Abstract This investigation was based on the hypothesis that weakly immunogenic, breast cancer-associated Ags, the products of mutant or dysregulated genes in the malignant cells, will be expressed in a highly immunogenic form by semiallogeneic IL-2-secreting fibroblasts transfected with DNA from breast cancer cells. (Classic studies indicate that transfection of genomic DNA can stably alter both the genotype and the phenotype of the cells that take up the exogenous DNA.) To investigate this question, we transfected LM mouse fibroblasts (H-2k) modified to secrete IL-2 with genomic DNA from a b

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Real, Mark, Walid M. Chalhoub та Nadim G. Haddad. "Itʼs in Her DNA: A Case Highlighting the Role of DNA Molecular Analysis in Intraductal Papillary Mucinous Neoplasm". American Journal of Gastroenterology 112 (жовтень 2017): S714—S715. http://dx.doi.org/10.14309/00000434-201710001-01314.

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Hei, Ailian, Hongbo Ma, Maogang Li, et al. "Benefit of Serum Thymidine Kinase 1 Concentration for Risk Assessment from Gastric Neoplasms Progression to Carcinomas: A Systematic Review and Meta-analysis." Clinics of Oncology 06, no. 05 (2022): 01–12. http://dx.doi.org/10.47829/coo.2022.6601.

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Background: Human Thymidine kinase 1 (hTK1), a key enzyme involved in the DNA synthesis during S-phase of the cell cycle and upregulation of cell proliferation, thus it is reliable tumor proliferating biomarker for assessment of tumor proliferation rate in serum and in tissue in oncology. This meta-analysis is investigation whether the serum TK1 concentration（STK1p）based on hTK1-IgY-polyclonal-antibody can provide a benefit for risk assessment from gastric neoplasm progression to gastric carcinoma (GC) as well as for evaluation of treatment effect in GC. 1.2. Methods: Relevant studies were ide

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Stonesifer, KJ, NA Benson, SE Ryden, DF Pawliger, and RC Braylan. "The malignant cells in a Lennert's lymphoma are T lymphocytes with a mature helper surface phenotype. A multiparameter flow cytometric analysis." Blood 68, no. 2 (1986): 426–29. http://dx.doi.org/10.1182/blood.v68.2.426.426.

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Abstract The flow cytometric analysis of DNA content in cells obtained from a case of Lennert's lymphoma demonstrated the presence of a discrete hypotetraploid cell population. Correlated multiparameter analysis of DNA, light scatter, and surface antigens by flow cytometry showed that the hypotetraploid cells were intermediate to large cells expressing T11, T3, and T4 antigens and lacking B1 and T8 antigens. These findings suggest that Lennert's lymphoma represents a malignant neoplasm of T- helper lymphocytes.

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Stonesifer, KJ, NA Benson, SE Ryden, DF Pawliger, and RC Braylan. "The malignant cells in a Lennert's lymphoma are T lymphocytes with a mature helper surface phenotype. A multiparameter flow cytometric analysis." Blood 68, no. 2 (1986): 426–29. http://dx.doi.org/10.1182/blood.v68.2.426.bloodjournal682426.

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The flow cytometric analysis of DNA content in cells obtained from a case of Lennert's lymphoma demonstrated the presence of a discrete hypotetraploid cell population. Correlated multiparameter analysis of DNA, light scatter, and surface antigens by flow cytometry showed that the hypotetraploid cells were intermediate to large cells expressing T11, T3, and T4 antigens and lacking B1 and T8 antigens. These findings suggest that Lennert's lymphoma represents a malignant neoplasm of T- helper lymphocytes.

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Alkan, Serhan, Ediz Cosar, Melek Ergin та Eric Hsi. "Detection of T-Cell Receptor-γ Gene Rearrangement in Lymphoproliferative Disorders by Temperature Gradient Gel Electrophoresis". Archives of Pathology & Laboratory Medicine 125, № 2 (2001): 202–7. http://dx.doi.org/10.5858/2001-125-0202-dotcrg.

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Abstract Objective.—Polymerase chain reaction amplification of DNA for T-cell receptor (TCR) gene rearrangement analysis is helpful in the evaluation of T-cell lymphoproliferative disorders. Detection of polymerase chain reaction products is limited by the poor resolution of bands analyzed by agarose or polyacrylamide gel electrophoresis. To improve the detection of a clonal T-cell population, we used temperature gradient gel electrophoresis (TGGE) as an alternative method for analysis of TCR gene rearrangement. Design.—One hundred eighteen archival DNA samples were randomly selected based on

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Karasaki, Hidenori, Yusuke Ono, Kazuya Koizumi, et al. "Cell-free DNA genotyping using digital PCR for early detection of pancreatic neoplasm." Journal of Clinical Oncology 34, no. 4_suppl (2016): TPS464. http://dx.doi.org/10.1200/jco.2016.34.4_suppl.tps464.

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TPS464 Background: Pancreatic ductal adenocarcinoma (PDA) is still a dismal disease, and there is an urgent need to establish novel tool for early diagnosis of the tumor. There are two main types of pathologically and genetically distinct precursors for PDA — pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasia (IPMN). Non-invasive markers for these precursor lesions have the potential to predict subsequent invasive tumor. Methods: Circulating cell-free DNA (cfDNA) released from tumor cells into the blood has been intensively studied as a novel way to monit

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Wu, Ming-Tsang, Shu-Yi Chen, Trong-Neng Wu, et al. "No association between polymorphisms of the DNA repair geneXRCC1 and cervical neoplasm risk." Environmental Health and Preventive Medicine 8, no. 3 (2003): 100–103. http://dx.doi.org/10.1007/bf02897923.

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Carretta, Chiara, Selene Mallia, Elena Genovese, et al. "Genomic Analysis of Hematopoietic Stem Cell at the Single-Cell Level: Optimization of Cell Fixation and Whole Genome Amplification (WGA) Protocol." International Journal of Molecular Sciences 21, no. 19 (2020): 7366. http://dx.doi.org/10.3390/ijms21197366.

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Single-cell genomics has become the method of choice for the study of heterogeneous cell populations and represents an elective application in defining the architecture and clonal evolution in hematological neoplasms. Reconstructing the clonal evolution of a neoplastic population therefore represents the main way to understand more deeply the pathogenesis of the neoplasm, but it is also a potential tool to understand the evolution of the tumor population with respect to its response to therapy. Pre-analytical phase for single-cell genomics analysis is crucial to obtain a cell population suitab

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Seibel, NL, and IR Kirsch. "Tumor detection through the use of immunoglobulin gene rearrangements combined with tissue in situ hybridization." Blood 74, no. 5 (1989): 1791–95. http://dx.doi.org/10.1182/blood.v74.5.1791.1791.

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Abstract Leukemias and lymphomas can now be classified according to the particular immunoglobulin, T-cell receptor, or growth-affecting genes they are expressing. Recognition of the structural alterations of lymphoid DNA has been used to identify neoplasms of previously uncertain lineage, to aid in diagnosis, and to define the state of differentiation of the neoplasm. We have developed a procedurally simple, rapid turnaround technique for using tumor-specific gene alterations as tumor-specific markers. Probes can be constructed that will recognize only the gene expressed in the tumor and not t

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Seibel, NL, and IR Kirsch. "Tumor detection through the use of immunoglobulin gene rearrangements combined with tissue in situ hybridization." Blood 74, no. 5 (1989): 1791–95. http://dx.doi.org/10.1182/blood.v74.5.1791.bloodjournal7451791.

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Leukemias and lymphomas can now be classified according to the particular immunoglobulin, T-cell receptor, or growth-affecting genes they are expressing. Recognition of the structural alterations of lymphoid DNA has been used to identify neoplasms of previously uncertain lineage, to aid in diagnosis, and to define the state of differentiation of the neoplasm. We have developed a procedurally simple, rapid turnaround technique for using tumor-specific gene alterations as tumor-specific markers. Probes can be constructed that will recognize only the gene expressed in the tumor and not those in a

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Kutyna, Monika M., Li Yan A. Wee, Sharon Paton, et al. "Therapy-Related Myeloid Neoplasm Has a Distinct Pro-Inflammatory Bone Marrow Microenvironment and Delayed DNA Damage Repair." Blood 136, Supplement 1 (2020): 37–38. http://dx.doi.org/10.1182/blood-2020-137277.

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Introduction: Therapy-related myeloid neoplasms (t-MN) are associated with extremely poor clinical outcomes in otherwise long-term cancer survivors. t-MN accounts for ~20% of cases of myeloid neoplasms and is expected to rise due to the increased use of chemotherapy/radiotherapy (CT/RT) and improved cancer survivorship. Historically, t-MN was considered a direct consequence of DNA damage induced in normal hematopoietic stem cells (HSC) by DNA damaging cytotoxics. However, these studies have largely ignored the bone marrow (BM) microenvironment and the effects of age and concurrent/previous can

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Wang, Yongbao, Justin Windham, Shere Billouin-Frazier, and Dan Jones. "Myeloid Lineage-Associated Mutations Are Detected in Blastic Plasmacytoid Dendritic Cell Neoplasm." Blood 120, no. 21 (2012): 5123. http://dx.doi.org/10.1182/blood.v120.21.5123.5123.

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Abstract Abstract 5123 Background/Purpose: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare but highly aggressive hematologic malignancy that frequently presents with skin, lymph node, and leukemic disease. Since BPDCN can evolve into acute myelomonocytic leukemia (AMML) with other cases associated with monocytosis, a close relationship of BPDCN to the myelomonocytic lineage is suspected. Here we investigate the frequency of myeloid-associated DNA mutations in BPDCN using a targeted exon sequencing panel. Methods: Nine cases of BPDCN (5 skin, 1 lymph node, 3 bone marrow clot sect

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Roa López, Gustavo A., Jhon Jairo Suárez, Paola Barato, and Noel Verján García. "Lack of association between Epstein–Barr virus and mammary tumours in dogs." Journal of Veterinary Research 62, no. 3 (2018): 309–15. http://dx.doi.org/10.2478/jvetres-2018-0045.

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AbstractIntroductionEpstein–Barr virus (EBV) is a γ-herpesvirus associated with various neoplasms in humans and is a probable aetiological agent in breast cancer; however, a causal relationship has not yet been established. Because of the epidemiological and clinicopathological similarities between breast cancer and canine mammary tumours, dogs have been proposed as a valid model for breast cancer.Material and MethodsA total of 47 canine mammary gland tumour tissues were processed by routine histopathological technique with haematoxylin-eosin staining and classified according to the type of ne

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Yadav, Rinki, Ashish Srivastava, Suresh Chandra, and A.K. Rai. "ROLE OF EPIGENETIC MECHANISMS IN VARIOUS CANCER THERAPIES." Pharmaceutical and Biological Evaluations 3, no. 2 (2016): 178–84. https://doi.org/10.5281/zenodo.51060.

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Epigenetics play a role not just in the normal functioning of the cell and its development, but also in diseases like neurological diseases and cancer. Epigenetic therapies can help to resolve non-identical problems of these pathophysiological conditions. Cancer is a complex disease with both genetic and epigenetic origins. The importance of epigenetics in cancer has been identified, and the field has emerged rapidly in recent years. Epigenetic and genetic alterations contribute to the initiation and progression of cancer. Epigenetic modifications introduced genetic changes, and usually occur

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Kutler, David I., Bhuvanesh Singh, Jaya Satagopan, et al. "A 20-year perspective on the International Fanconi Anemia Registry (IFAR)." Blood 101, no. 4 (2003): 1249–56. http://dx.doi.org/10.1182/blood-2002-07-2170.

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Fanconi anemia (FA) is an autosomal recessive disorder characterized by cellular hypersensitivity to DNA cross-linking agents and cancer predisposition. Recent evidence for the interactions of ataxia-telangiectasia mutated protein ATM and breast cancer susceptibility proteins BRCA1 and BRCA2 (identified as FANCD1) with other known FA proteins suggests that FA proteins have a significant role in DNA repair/recombination and cell cycle control. The International Fanconi Anemia Registry (IFAR), a prospectively collected database of FA patients, allows us the unique opportunity to analyze the natu

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Gallo, Oreste, Simonetta Di Lollo, Paola Graziani, Ezio Gallina, and Gianna Baroni. "Detection of Epstein-Barr Virus Genome in Sinonasal Undifferentiated Carcinoma by Use of in Situ Hybridization." Otolaryngology–Head and Neck Surgery 112, no. 6 (1995): 659–64. http://dx.doi.org/10.1016/s0194-59989570172-9.

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Associations between Epstein-Barr virus and undifferentiated carcinomas of nasopharynx, parotid gland, and thymus have recently been reported. Epstein-Barr virus has also been associated with malignant lymphoma of the nose and paranasal sinuses. These findings raise the possibility that Epstein-Barr virus may additionally be linked to undifferentiated carcinoma of the nose and paranasal sinuses (SNUC), an uncommon but distinctive and highly aggressive neoplasm. Histologically, SNUC consists of small and medium cells, the precise characterization of which often requires immunocytochemical analy

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Kutyna, Monika M., Amilia Wee, Sharon Paton, et al. "Aberrant Bone Marrow Microenvironment in Therapy Related Myeloid Neoplasm (t-MN)." Blood 134, Supplement_1 (2019): 1694. http://dx.doi.org/10.1182/blood-2019-126457.

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Introduction: Therapy-related myeloid neoplasm (t-MN) is a lethal second hematological malignancy following chemotherapy (CT) and radiotherapy (RT) for primary cancers. It accounts for 15-20% of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). AML and MDS are considered to be hematopoietic stem cell (HSC)-autonomous disorders, in which initiation and progression are mainly driven by HSC-intrinsic genetic events. However, emerging data suggest that bone marrow (BM) microenvironment plays critical role in initiation and evolution of MDS and AML (Raaijmakers et al., 2010). Malign

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Al Alwan, N. A. S. "DNA proliferative index as a marker in Iraqi aneuploid mammary carcinoma." Eastern Mediterranean Health Journal 6, no. 5-6 (2000): 1062–72. http://dx.doi.org/10.26719/2000.6.5-6.1062.

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This study estimated nuclear DNA ploidy and DNA proliferative indices [PI]in mammary ductal carcinomas from 120 Iraqi female patients. Of the examined specimens, 82.7% were aneuploid. DNA ploidy correlated significantly with histological grade and estrogen receptor content of the primary neoplasm. In aneuploid carcinomas, high PI showed a clearer association than aneuploidy with menopausal status and progesterone receptor content of the tumour. PI and percentage aneuploidy were higher in larger tumours; nodal status showed no association with these cytometric findings. Using PI, patients class

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De Luise, Monica, Vito Guarnieri, Claudio Ceccarelli, Leonardo D’Agruma, Anna Maria Porcelli та Giuseppe Gasparre. "A Nonsense Mitochondrial DNA Mutation Associates with Dysfunction of HIF1α in a Von Hippel-Lindau Renal Oncocytoma". Oxidative Medicine and Cellular Longevity 2019 (9 січня 2019): 1–5. http://dx.doi.org/10.1155/2019/8069583.

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The Von Hippel-Lindau (VHL) syndrome has been rarely associated with renal oncocytomas, and tumors usually show HIF1α chronic stabilization. By contrast, oncocytomas mainly associated with respiratory chain (RC) defects due to severe mitochondrial DNA (mtDNA) mutations are incapable of stabilizing HIF1α, since oxygen consumption by the RC is dramatically diminished and prolylhydroxylase activity is increased by α-ketoglutarate accumulation following Krebs cycle slowdown. Here, we investigate the cooccurrence of a pseudohypoxic condition with oncocytic transformation in a case of VHL-associated

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Di Francia, Raffaele, Stefania Crisci, Tommaso Muto, et al. "Optimization of a Low-Cost, Sensitive PNA Clamping PCR Method for JAK2 V617F Variant Detection." Journal of Applied Laboratory Medicine 5, no. 4 (2020): 643–55. http://dx.doi.org/10.1093/jalm/jfaa041.

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Abstract Background The JAK2 V617F variant is diagnostic for myeloproliferative neoplasms, a group of clonal disorders of hematopoietic stem and progenitor cells. Although several approaches have been developed to detect the variant, a gold standard diagnostic method has not yet been defined. We describe a simple, fast, and cost-effective PCR-based approach that enhances test specificity and sensitivity by blocking the amplification of the large excess of wild-type DNA. Methods The method involves using an oligo peptide nucleic acid (PNA) perfectly matching its corresponding DNA sequence. The

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Salta, Sofia, Sandra P. Nunes, Mário Fontes-Sousa, et al. "A DNA Methylation-Based Test for Breast Cancer Detection in Circulating Cell-Free DNA." Journal of Clinical Medicine 7, no. 11 (2018): 420. http://dx.doi.org/10.3390/jcm7110420.

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Background: Breast cancer (BrC) is the most frequent neoplasm in women. New biomarkers, including aberrant DNA methylation, may improve BrC management. Herein, we evaluated the detection and prognostic performance of seven genes’ promoter methylation (APC, BRCA1, CCND2, FOXA1, PSAT1, RASSF1A and SCGB3A1). Methods: Methylation levels were assessed in primary BrC tissues by quantitative methylation-specific polymerase chain reaction (QMSP) and in circulating cell-free DNA (ccfDNA) by multiplex QMSP from two independent cohorts of patients (Cohort #1, n = 137; and Cohort #2, n = 44). Receiver ope

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Gale, Robert, John M. Bennett, and F. Owen Hoffman. "WHO HAS THERAPY-RELATED AML?" Mediterranean Journal of Hematology and Infectious Diseases 9, no. 1 (2017): e2017025. http://dx.doi.org/10.4084/mjhid.2017.025.

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Therapy-related leukemia or therapy-related myeloid neoplasm are widely-used terms to designate leukemia developing in persons who previously received anti-cancer therapy (for example, see references 1, 2), especially if the prior anti-cancer therapy included drugs such as alkylators, DNA-intercalators, topoisomerase-2-inhibitors, purines and/or ionizing radiations. Sometimes specific genes such as AML1, EVI1, NRAS or MLL are mutated by therapy or gene variants are produced which activate mutagens or interfere with DNA repair, such FANC, NQ01 or AML2. 3-5 But how can we know if AML in someone

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Liu, Darren, Lamis Yehia, Andrew Dhawan, Ying Ni, and Charis Eng. "Abstract 979: Cell-free DNA fragmentomics and second malignant neoplasm risk in patients with PTEN hamartoma tumor syndrome." Cancer Research 84, no. 6_Supplement (2024): 979. http://dx.doi.org/10.1158/1538-7445.am2024-979.

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Abstract Individuals with PTEN hamartoma tumor syndrome (PHTS) harbor germline PTEN variants that confer a significantly increased lifetime risk of various organ-specific cancers, and a 7-fold increased risk of second primary malignant neoplasms (SMNs). Currently, there is no reliable biomarker that can accurately predict which individuals with PHTS will develop malignancies, let alone SMN. Currently, there is no reliable biomarker that can accurately predict which individuals with PHTS will develop malignancies, let alone SMN. Despite the highly promising value of cell-free DNA (cfDNA) as a b

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Tsai, H. T. "Association between Quantitative High-Risk Human Papillomavirus DNA Load and Cervical Intraepithelial Neoplasm Risk." Cancer Epidemiology Biomarkers & Prevention 14, no. 11 (2005): 2544–49. http://dx.doi.org/10.1158/1055-9965.epi-05-0240.

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Oliveira, RTG, ME Escócia, LR Sampaio, et al. "SCREENING OF ONCOGENIC VARIANTS IN DNA POLYMERASES WITH TRANSLESION SYNTHESIS ACTIVITY IN MYELODYSPLASTIC NEOPLASM." Hematology, Transfusion and Cell Therapy 45 (October 2023): S443. http://dx.doi.org/10.1016/j.htct.2023.09.828.

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Taylor, Justin, Mark Donoghue, Raajit K. Rampal, et al. "Hematologic Malignancies Arising in Patients with Germ Cell Tumors: Secondary Somatic Differentiation of Hematopoietic Malignancies from Germ Cell Precursors." Blood 132, Supplement 1 (2018): 87. http://dx.doi.org/10.1182/blood-2018-99-111976.

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Abstract Genomic analyses have recently illuminated our understanding of therapy-associated myeloid neoplasms in patients receiving therapy for other cancers. One of the most intriguing relationships between solid tumors and myeloid neoplasms involves a unique clinical entity of patients with germ cell tumors (GCT) and myeloid neoplasms. One in 17 patients with primary mediastinal germ cell tumor (PMGCT) develops a hematologic malignancy (most commonly AML, MDS, or histiocytosis) and the median survival in such patients is poor at only 5 months. Intriguingly, the presence of isochromosome 12p

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Pasic, I., A. Shlien, A. Novokmet, et al. "CONTRIBUTION OF DNA COPY-NUMBER VARIATION (CNV) TO CANCER SUSCEPTIBILITY AND LARGE-SCALE GENOME ALTERATIONS IN OSTEOSARCOMA (OS)." Clinical & Investigative Medicine 31, no. 4 (2008): 19. http://dx.doi.org/10.25011/cim.v31i4.4821.

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Introduction: OS, a common Li-Fraumeni syndrome (LFS)-associated neoplasm, is a common bone malignancy of children and adolescents. Sporadic OS is also characterized by young age of onset and high genomic instability, suggesting a genetic contribution to disease. This study examined the contribution of novel DNA structural variation elements, CNVs, to OS susceptibility. Given our finding of excessive constitutional DNA CNV in LFS patients, which often coincide with cancer-related genes, we hypothesized that constitutional CNV may also provide clues about the aetiology of LFS-related sporadic n

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