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Academic literature on the topic 'Neoplasms – Therapy – Popular works'

Author: Grafiati
Published: 4 June 2021
Last updated: 27 January 2023

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Journal articles on the topic "Neoplasms – Therapy – Popular works"

1

Wiegand, Susanne, Andreas Dietz, and Gunnar Wichmann. "Malignant Vascular Tumors of the Head and Neck—Which Type of Therapy Works Best?" Cancers 13, no. 24 (December 9, 2021): 6201. http://dx.doi.org/10.3390/cancers13246201.

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Malignant vascular tumors of the head and neck are rare neoplasms with variable clinical presentation, wide age distribution, and variable clinical courses. The heterogeneous presentation of angiosarcomas and epithelioid hemangioendothelioma often leads to misdiagnosis and unsuitable treatment. While risk factors for angiosarcomas are previous radiation, chronic lymphedema, and exposure to arsenic, thorium oxide, or vinyl chloride, there are only limited and retrospective data available on prognostic factors in EHE. In both angiosarcomas and EHE, surgery is the mainstay of treatment. There is limited evidence regarding the role of radiotherapy in EHE, although EHE is considered relatively radiosensitive. In angiosarcomas, adjuvant radiotherapy is recommended according to retrospective case series. A standard medical therapy for metastasized malignant vascular tumors is lacking. Chemotherapy, which is effective in angiosarcoma, is mostly ineffective in EHE. Targeted therapy, antiangiogenetic drugs and immunotherapy have been studied as new treatment options. The goal of this review is to summarize the current data regarding malignant vascular tumors along with their diagnosis and management.
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2

Roex, Gils, Tom Feys, Yves Beguin, Tessa Kerre, Xavier Poiré, Philippe Lewalle, Peter Vandenberghe, Dominique Bron, and Sébastien Anguille. "Chimeric Antigen Receptor-T-Cell Therapy for B-Cell Hematological Malignancies: An Update of the Pivotal Clinical Trial Data." Pharmaceutics 12, no. 2 (February 24, 2020): 194. http://dx.doi.org/10.3390/pharmaceutics12020194.

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Chimeric antigen receptor (CAR)-T-cell therapy is an innovative form of adoptive cell therapy that has revolutionized the treatment of certain hematological malignancies, including B-cell non-Hodgkin lymphoma (NHL) and B-cell acute lymphoblastic leukemia (ALL). The treatment is currently also being studied in other B-cell neoplasms, including multiple myeloma (MM) and chronic lymphocytic leukemia (CLL). CD19 and B-cell maturation antigen (BCMA) have been the most popular target antigens for CAR-T-cell immunotherapy of these malignancies. This review will discuss the efficacy and toxicity data from the pivotal clinical studies of CD19- and BCMA-targeted CAR-T-cell therapies in relapsed/refractory B-cell malignancies (NHL, ALL, CLL) and MM, respectively.
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3

Bouras-vallianatos, Petros. "Clinical Experience in Late Antiquity: Alexander of Tralles and the Therapy of Epilepsy." Medical History 58, no. 3 (June 19, 2014): 337–53. http://dx.doi.org/10.1017/mdh.2014.27.

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AbstractAlexander of Tralles, writing in the late sixth century, combined his wide-ranging practical knowledge with earlier medical theories. This article shows how clinical experience is used in Alexander’s works by concentrating on his therapeutic advice on epilepsy and, in particular, on pharmacology and the group of so-called natural remedies. I argue that clinical testing is used not only for the introduction of new medicines but also as an instrument for checking the therapeutic effect of popular healing practices. On another level, this article discusses Alexander’s role as the author of a medical compendium; it suggests that by marking the cases of clinical testing with a set of recurrent expressions, Alexander leads his audience to reflect on his medical authority and personal contribution.
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4

Vaghasiya, Mahendra Haribhai, Sanjay Kumar Dayani, Ravi Munasing Rathod, Arun Kumar Chatterjee, Balachandra S. Ankad, Saleem Abdulhasanbeg Jamadar, Umesh Omkarlal Agrawal, Jayesh Sanaryia Amrutlal, Mahendra Kumar Singhi, and Mashkoor Ahmed Wani. "Topical therapy of various dermatoses with ImpoyzTM (clobetasol propionate) cream 0.025%." International Journal of Advances in Medicine 9, no. 3 (February 23, 2022): 330. http://dx.doi.org/10.18203/2349-3933.ijam20220438.

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The most widely prescribed drugs for the treatment of a variety of dermatoses are Topical corticosteroids (TC). These medications are approved for the treatment of inflammatory and pruritic manifestations of dermatologic disorders due to their powerful symptom-relieving impact. Clobetasol propionate (CP) is the most popular (TC) used to relieve itching, redness, and oedema caused by a variety of skin disorders. Anti-inflammatory, anti-pruritic, and vasoconstrictive characteristics are all present in it. CP works by binding to cytoplasmic glucocorticoid receptors and activating glucocorticoid receptor-mediated gene expression, resulting in the production of anti-inflammatory proteins while suppressing the production of inflammatory mediators. The formulation is free from known contact allergens, such as propylene glycol, short-chain alcohols, and sorbitol-based emulsifiers, and has demonstrated hypoallergenic effects. The efficacy, safety, and clinical experience of utilizing CP 0.025% cream for the treatment of various dermatologic disorders are discussed in this case series.
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5

Ji, Bo-Ya, Liang-Rui Pan, Ji-Ren Zhou, Zhu-Hong You, and Shao-Liang Peng. "SMMDA: Predicting miRNA-Disease Associations by Incorporating Multiple Similarity Profiles and a Novel Disease Representation." Biology 11, no. 5 (May 20, 2022): 777. http://dx.doi.org/10.3390/biology11050777.

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Increasing evidence has suggested that microRNAs (miRNAs) are significant in research on human diseases. Predicting possible associations between miRNAs and diseases would provide new perspectives on disease diagnosis, pathogenesis, and gene therapy. However, considering the intrinsic time-consuming and expensive cost of traditional Vitro studies, there is an urgent need for a computational approach that would allow researchers to identify potential associations between miRNAs and diseases for further research. In this paper, we presented a novel computational method called SMMDA to predict potential miRNA-disease associations. In particular, SMMDA first utilized a new disease representation method (MeSHHeading2vec) based on the network embedding algorithm and then fused it with Gaussian interaction profile kernel similarity information of miRNAs and diseases, disease semantic similarity, and miRNA functional similarity. Secondly, SMMDA utilized a deep auto-coder network to transform the original features further to achieve a better feature representation. Finally, the ensemble learning model, XGBoost, was used as the underlying training and prediction method for SMMDA. In the results, SMMDA acquired a mean accuracy of 86.68% with a standard deviation of 0.42% and a mean AUC of 94.07% with a standard deviation of 0.23%, outperforming many previous works. Moreover, we also compared the predictive ability of SMMDA with different classifiers and different feature descriptors. In the case studies of three common Human diseases, the top 50 candidate miRNAs have 47 (esophageal neoplasms), 48 (breast neoplasms), and 48 (colon neoplasms) are successfully verified by two other databases. The experimental results proved that SMMDA has a reliable prediction ability in predicting potential miRNA-disease associations. Therefore, it is anticipated that SMMDA could be an effective tool for biomedical researchers.
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6

Tsivyan, Boris L. "ORGANIZATIONAL APPROACHES TO REHABILITATION OF PATIENTS WITH BENIGN NEOPLASMAS OF THE GYNECOLOGICAL SPHERE IN SANATORIC CONDITIONS." Medical and Social Expert Evaluation and Rehabilitation 20, no. 2 (June 15, 2017): 65–68. http://dx.doi.org/10.18821/1560-9537-2017-20-2-65-68.

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The article discusses the issues of providing rehabilitation care in sanatorium-and-spa facilities to patients with benign neoplasms of the gynecological sphere. The importance of this issue is caused by the high percentage of physiological and psychological disorders occurring in patients of this group in the period of postoperative recovery. In the course of the study, there was executed the assessment of the effectiveness of the organization of sanatorium-and-spa care for patients with benign neoplasms of the gynecological sphere on the example of the experience of a foreign sanatorium-and-spa institution. The study was carried out from the position of the study of the medical documentation of this center, as well as the opinion of patients regarding the provision of assistance in these institutions. It was important that every fourth patient who underwent treatment in a sanatorium-resort environment was a woman of a rather young age, of from 31 to 45 years. Climatic therapy and physiotherapy exercises were carried out in all cases of sanatorium treatment of patients with diseases of this group. Such methods of the treatment as psychotherapy, manual therapy and physiotherapy were popular. Based on the results of rehabilitation in a sanatorium and SPA establishment, in almost all cases, a number of important issues is being resolved, such as maintaining working capacity, social integration into society, preventing of possible violations of functions and preventing and reducing the degree of possible disability, maintaining functions in the process of the current pathological condition. It is important that all the interviewed patients are generally satisfied with the treatment provided to them, while 93.7% of them are completely satisfied and 6.3% indicated that «yes, they are more satisfied».
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7

Altunbay, Müzeyyen. "Using Literature in Bibliotheraphy: Biography Sampling." Journal of Education and Training Studies 6, no. 11 (October 9, 2018): 201. http://dx.doi.org/10.11114/jets.v6i11.3593.

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Bibliotherapy is consisted of a combination of the Greek “biblion (book)” and “therapeia (therapy-healing)” which have become popular since the 20th century as one of the alternative therapy methods. It is used to make individuals identify themselves with the works they read through works of high literary and aesthetic value and make them powerful individuals in the spiritual direction by producing solutions to the problems they experience in this way. In other words, bibliotherapy can also be defined as bringing the right books to the individual at the right time. That is, the history of accepting the idea that books are good for man is very old. In this study, the importance of using biographies will be explained in one of the important alternative therapy methods, bibliotherapy. There are some criteria in the selection of books because they are the most important materials that form the basis of bibliotherapy. As it is known, the process is three dimensions as the advisee, book preference and consultant. However, it is not possible to use every work in bibliotherapy. It is important to use the works that are high in reality dimension and keeping a mirror on the problems of the individual in bibliotherapy. This process includes the works that will develop the imaginary world of the individual, as well as the works suitable for real life. As is known, the common point in biographies is not only the success that the person who wrote the biography has achieved, but also this person's struggle for reaching his goal is his patience and perseverance. As a result, in the process of bibliotherapy, reading the biographies that will increase the morale and motivation of the individual and develop self-confidence will contribute positively to the person. Moreover, the preference of the biographies of the positive role-model in the society will be the example for the individual.
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8

Tsalikova, I. K., and S. V. Pakhotina. "The issue of motivation for foreign languages learning in international research works: Scoping review." Education and science journal 23, no. 5 (May 23, 2021): 38–63. http://dx.doi.org/10.17853/1994-5639-2021-5-38-63.

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Introduction. Today, foreign language competence of a person is a necessary means of active social and professional life. Despite this, quite a lot of young people do not always have the desire to learn foreign languages. This paradox made the motivation to learn foreign languages a popular issue to research worldwide. The article presents the scoping review of international studies devoted to the issue of motivation to learn foreign languages. First of all, it is necessary to understand the research trends in the study of this issue in general, and to determine factors, which influence the lack of students' interest to learn foreign languages in particular.The aim of the present research is to outline the current focus trends and to define the gaps in international research papers aimed at investigating the issue of motivation for foreign languages learning.Methodology and research methods. The methodological framework of the current research is based on the qualitative content analysis of relevant empirical research on this issue from the periodicals indexed by the international databases Scopus and Web of Science over the last 15 years. This review will provide an understanding of the degree of knowledge of the analysed issues at the international level.Results. The research works on the issues of motivation for foreign languages learning were divided into two main categories: the research works concentrated on inner - academic and professional factors, and the works which deal with the outer - social factors of influence. Within these groups, the existing research trends and the most promising research areas were identified (for instance, the influence of peers on the motivational sphere of students). Amongst the numerous works investigating external (socio-economic) factors of influence, there is insufficient research on the influence of macro-political and macro-economic factors on the motivation for learning languages (for instance, foreign languages learning preferences). The research outcomes will contribute to understanding the factors, which influence the students' lack of interest in learning foreign languages.The scientific novelty is in the originality of the demonstrated review, which includes many scientific papers performed by scientists from all over the world and based on various research procedures. In the review, the geographical principle of data selection was not used and the publication date was not taken into account. The main selection criterion was a research paper to be published in a journal peer-reviewed by international databases over the last 15 years.Such a principle was necessary to understand research trends in the issue of motivation for mastering a foreign language competence and to determine similar (or specific) factors for different countries, which cause students' lack of interest in learning foreign languages.Practical significance. The results of the obtained analysis will give understanding of the reasons for the lack of students' motivation to study foreign languages. Moreover, it will help to find a solution to this international challenge.
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9

Schmid, Lorrie, Lauren DeMoss, Paige Scarbrough, Carol Ripple, Yasmine White, and Geraldine Dawson. "An Investigation of a Classroom-Based Specialized Music Therapy Model for Children With Autism Spectrum Disorder: Voices Together Using the VOICSS™ Method." Focus on Autism and Other Developmental Disabilities 35, no. 3 (January 31, 2020): 176–85. http://dx.doi.org/10.1177/1088357620902505.

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Students with autism spectrum disorder (ASD) have marked deficits in social communication skills, which can challenge their ability to participate in academic and social activities. Music therapy is a popular intervention for children with ASD, and although research evidence supporting its effectiveness is growing, methodological flaws limit interpretation. The present study proposes a new measure, the DUACS, to assess outcomes associated with a group music therapy program, Voices Together. Participants were 64 elementary students from nine self-contained autism classrooms who attended 16 weekly intervention sessions. Teacher-reported behavior questionnaires and direct student behavioral measures were administered at baseline, during, and after treatment. Increases in communication and social skills suggested program effectiveness, particularly among students with higher baseline skills. Further investigation of this program approach will help to better understand its mechanisms and for whom it works best.
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10

Carvalho, Juliana Santos, Anna Flávia Silva Alves Silva, Maysa Coité Silva, Itala Gomes Santos, Laryssa Pinto Aragão, Larissa Ferreira Lucas, Herbert Henrique de Melo Santos, et al. "First Description of Upfront Target Therapy Treating AML and Bcll Presented Simultaneously As First Line." Blood 136, Supplement 1 (November 5, 2020): 25–26. http://dx.doi.org/10.1182/blood-2020-143224.

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INTRODUCTION: The occurrence of acute myeloid leukemia (AML) and chronic lymphoid leukemia (B-CLL) simultaneously is rarely described. We describe a case report of AML and B-CLL, diagnosed simultaneously, without any previous treatment for any of the hematological neoplasms [1]. The patient received low-dose cytarabine (ARA-C) and Venetoclax, which is medically indicated on label for both hematological neoplasms. CASE REPORT: A 75-year-old male, presented with edema and joint pain one month before hospital admission, showing pancytopenia on a complete blood count and presence of blasts in peripheral blood. The patient was then referred to the hematology service. The morphological analysis of the bone marrow aspirate showed 67.7% of myeloblasts, compatible with AML. Bone marrow immunophenotyping was performed, which identified 34.10% of myeloblasts, compatible with AML and 50.48% of monoclonal B lymphocytes (chronic B-cell lymphoproliferative disease). In flow cytometry there were two distinct populations of myeloblasts. Type 1 myeloblasts labeling CD7 +, CD13 +, CD34 ++, CD38 ++, CD45 ++, CD56 ++, CD117 ++, CD123 +, HLA-DR +++ and MPO + / ++. The second population marked CD13 + / ++, CD34 + / ++, CD38 ++, CD45 +, CD117 ++, CD123 +, HLA-DR ++ / +++ and MPO + (30%). Monoclonal lymphocytes showed CD11c + / ++ (70%), CD19 ++, CD20 + / ++ (84%), CD22 + (39%), CD23 + / ++, CD25 +, CD31 +/-, CD43 ++, CD45 ++ / +++, CD81 + (38%), CD200 + (85%) and Lambda +. The molecular study was negative for genetic abnormalities: FLT3, KIT and NPM, configuring the patient as an intermediate risk for AML. In the cytogenetic analysis there was no growth of metaphases. Patient received simultaneous diagnosis of AML and B-CLL. As he was ineligle to intensive chemotherapy (IC), we started original protocol Subcutaneous Cytarabin+venetoclax(VIALE C). The patient had grade 2-3 AE(neutropenia managed with GCSF) ending the fourth cycle in July 2020. The evolution of hematimetric parameters and diseases are described in graphics. DISCUSSION: This is the first described case in our knowledge treated upfront with bcl2-inh target therapy for two absolutely different hematological neoplasms: AML and BCLL. Nowadays we are experiencing a new therapeutic model in oncohematology, in which the targeted therapy is gaining ground in relation to IC with excellent results. In this way, the importance of comprehension of the pathophysiological mechanism of the neoplasms and the way we can stop the disease proliferation is progressively guiding the new protocols. Elderly patients are more likely to have early treatment-related death and exhibit therapeutic resistance, limiting alternatives. We decided to start first-line treatment with ARA-C and Venetoclax [2]. Venetoclax associated with ARA-C has a manageable safety profile, producing quick and durable remissions in elderly people with AML ineligible for IC, as well as in B CLL, being the best therapeutic alternative for the case, in our opinion. Venetoclax belongs to a group of drugs called Bcl-2 inhibitors, an anti-apoptotic protein, which works by blocking this protein in the body, causing apoptosis of both neoplastic cells. The high rate of remission and low early mortality, combined with fast and durable remission, make Venetoclax and ARA-C a new and attractive treatment for the elderly [2]. In our case, the intention of the product in the first line was not B-CLL, but it would certainly be a good option for this profile of elderly patients. CONCLUSION: We report the first description of simultaneous diagnosis of AML and B CLL treated with a Bcl-2 inhibitor, demonstrating that antitumor mechanisms can be extremely effective in completely different diseases. We have a long way to go in the search for full knowledge of oncohematological diseases and targeted therapies. However, this case report shows that we are on the right track. References: 1. MUSSAED, Eman Al; OSMAN, Hani; ELYAMANY, Ghaleb. Simultaneous existence of acute myeloid leukemia and chronic lymphocytic leukemia: a case report.Bmc Cancer.Springer Science and Business Media LLC. http://dx.doi.org/10.1186/s12885-016-2780-5. 2. WEI, Andrew H.; et al. Venetoclax Combined With Low-Dose Cytarabine for Previously Untreated Patients With Acute Myeloid Leukemia: results from a phase ib/ii study.Journal Of Clinical Oncology, [S.L.], 20 maio 2019. American Society of Clinical Oncology (ASCO). http://dx.doi.org/10.1200/jco.18.01600. Figure Disclosures De Queiroz Crusoe: Janssen:Research Funding.
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Books on the topic "Neoplasms – Therapy – Popular works"

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H, Rosenbaum Ernest, Cable Greg 1946-, and Dollinger Malin, eds. Cancer therapy. 2nd ed. Kansas City: Andrews and McMeel, 1994.

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Judith, McKay, and Judith McKay. The chemotherapy & radiation therapy survival guide. Oakland, CA: New Harbinger Publications, 1998.

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Michael, Lerner. Choices in healing: Integrating the best of conventional and complementary approaches to cancer. Cambridge, Mass: MIT Press, 1996.

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Steeves, Richard A. A cancer patient's guide to radiation therapy. Madison, Wis: Medical Physics Pub., 1992.

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H, Rosenbaum Ernest, and Dollinger Malin, eds. Everyone's guide to cancer therapy: How cancer is diagnosed, treated, and managed day to day. 5th ed. Kansas City: Andrews McMeel Pub., 2007.

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Kornmehl, Carol L. The best news about radiation therapy: How to cope and survive. Howell, NJ: Academic Radiation Oncology Press, 2003.

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Coleman, C. Norman. Understanding cancer: A patient's guide to diagnosis, prognosis, and treatment. 2nd ed. Baltimore: Johns Hopkins University Press, 2006.

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Siegel, Mary-Ellen. The cancer patient's handbook: Everything you need to know about today's care and treatment. New York: Walker, 1986.

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Ko, Andrew H. Everyone's guide to cancer therapy: How cancer is diagnosed, treated, and managed day to day. 5th ed. Kansas City: Andrews McMeel Pub., 2008.

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Benedet, Rosalind Dolores. After mastectomy: Healing physically and emotionally. Omaha, Neb: Addicus Books, 2003.

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Conference papers on the topic "Neoplasms – Therapy – Popular works"

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Agrawal, Sunil K., Glenn Gardner, and Stephen Pledgie. "Design and Fabrication of a Gravity Balanced Planar Mechanism Using Auxiliary Parallelograms." In ASME 2000 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/detc2000/mech-14073.

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Abstract Exercise machines are becoming increasingly popular in rehbilitation and physical therapy. Gravity balancing is an important feature that is sought after in rehabilitative machines in order to make these accessible to patients with low muscular ability. Often, gravity loads in a mechanism are compensated by feed-forward actuator efforts that quasi-statically balance the mechanism in a configuration and are applied in addition to the actuator efforts required to perform a task. Such a scheme works but places large demands on the actuators. Also, actuator efforts are required at every joint in order to keep the mechanism balanced. This paper describes the design and fabrication of a gravity balanced planar mechanism, where auxiliary parallelograms are used to identify the center of mass of the augmented mechanism. A sliding carriage positions a counterweight directly above the center of mass in order to make the system gravity balanced. The sliding carriage uses joint encoder data to compute the location of the center of mass. Experiment results are presented which demonstrate the effectiveness of the approach.
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