Relevant bibliographies by topics / Neoplastic/drug effects

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Neoplastic/drug effects'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Neoplastic/drug effects"

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Ghanim, Viviane, Harald Herrmann, Gerwin Heller, et al. "5-azacytidine and decitabine exert proapoptotic effects on neoplastic mast cells: role of FAS-demethylation and FAS re-expression, and synergism with FAS-ligand." Blood 119, no. 18 (2012): 4242–52. http://dx.doi.org/10.1182/blood-2011-09-382770.

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Abstract Aggressive systemic mastocytosis (ASM) and mast cell leukemia (MCL) are advanced hematopoietic neoplasms with poor prognosis. In these patients, neoplastic mast cells (MCs) are resistant against various drugs. We examined the effects of 2 demethylating agents, 5-azacytidine and decitabine on growth and survival of neoplastic MCs and the MC line HMC-1. Two HMC-1 subclones were used, HMC-1.1 lacking KIT D816V and HMC-1.2 exhibiting KIT D816V. Both agents induced apoptosis in HMC-1.1 and HMC-1.2 cells. Decitabine, but not 5-azacytidine, also produced a G2/M cell-cycle arrest in HMC-1 cel
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Schneeweiss-Gleixner, Mathias, Yüksel Filik, Gabriele Stefanzl, et al. "CDK4/CDK6 Inhibitors Synergize with Midostaurin, Avapritinib, and Nintedanib in Inducing Growth Inhibition in KIT D816V+ Neoplastic Mast Cells." Cancers 14, no. 13 (2022): 3070. http://dx.doi.org/10.3390/cancers14133070.

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In most patients with advanced systemic mastocytosis (AdvSM), neoplastic mast cells (MC) express KIT D816V. However, despite their disease-modifying potential, KIT D816V-targeting drugs, including midostaurin and avapritinib, may not produce long-term remissions in all patients. Cyclin-dependent kinase (CDK) 4 and CDK6 are promising targets in oncology. We found that shRNA-mediated knockdown of CDK4 and CDK6 results in growth arrest in the KIT D816V+ MC line HMC-1.2. The CDK4/CDK6 inhibitors palbociclib, ribociclib, and abemaciclib suppressed the proliferation in primary neoplastic MC as well
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Ghanim, Viviane, Harald Herrmann, Emir Hadzijusufovic, et al. "5-Azacytidine and Decitabine Induce FAS Re-Expression, Exert Major Proapoptotic Effects, and Cooperate with the FAS Ligand in Producing Apoptosis in Neoplastic Human Mast Cells,." Blood 118, no. 21 (2011): 3457. http://dx.doi.org/10.1182/blood.v118.21.3457.3457.

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Abstract Abstract 3457 Aggressive systemic mastocytosis (ASM) and mast cell leukemia (MCL) are advanced myeloid neoplasms with a poor prognosis. In these patients, neoplastic mast cells (MC) are resistant against most conventional drugs. Demethylating agents reportedly exert beneficial effects in several advanced myelogenous neoplasms, including myelodysplastic syndromes. We examined the effects of two demethylating agents, 5-Azacytidine and 5-Aza-2`Deoxycytidine (Decitabine) on growth and survival (apoptosis) of neoplastic MC and the human MC line HMC-1. Two HMC-1 subclones were used, HMC-1.1
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Ubertini, Valentina, Frida Ponthan, Aude-Marine Bonavita, and James Wilson. "Abstract 2754: Transwell-grown monolayers derived from small intestinal organoids to study the effects of tight junction modulators that may improve the absorption of orally-administered, anti-neoplastic drugs." Cancer Research 83, no. 7_Supplement (2023): 2754. http://dx.doi.org/10.1158/1538-7445.am2023-2754.

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Abstract Although oral dosing is the most convenient route of drug administration, most anti-neoplastic drugs are administered intravenously due to poor bioavailability because of the epithelial barriers. A major organ involved in oral drug absorption is the small intestine where enterocytes are linked together by tight junctions (TJs). TJs regulate paracellular transport by creating a selectively permeable barrier to small molecules, ions, and water, thereby restricting the uptake of drugs. Transient modulation of the TJs is considered a potential strategy to improve drug delivery. Human smal
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Tomas Koltai. "Fundamentals for the repurposing of hydralazine as an anti-neoplastic drug." World Journal of Advanced Pharmaceutical and Life Sciences 5, no. 1 (2023): 012–23. http://dx.doi.org/10.53346/wjapls.2023.5.1.0075.

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Hydralazine (HDZ) is a drug patented in 1949 that has been used for the treatment of arterial hypertension since 1953. New and better anti-hypertensive drugs have almost moved HDZ into oblivion. Interestingly, anti-cancer effects were found and this drug is seriously being considered for repurposing it for cancer treatment. The main mechanism of action against tumors seems to be its ability to act as a demethylator agent. By demethylating the promoter region of tumor suppressor genes HDZ seems to restore the effects of these genes, which are frequently inhibited in cancer through epigenetic me
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Schneeweiss, Mathias A., Gabriele Stefanzl, Daniela Berger, et al. "The CDK4/6 Inhibitor Palbociclib Exerts Growth-Inhibitory Effects on Neoplastic Mast Cells and Synergizes with Midostaurin in Producing Growth Arrest." Blood 132, Supplement 1 (2018): 1363. http://dx.doi.org/10.1182/blood-2018-99-116525.

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Abstract Aggressive systemic mastocytosis (ASM) and mast cell leukemia (MCL) are rare, malignant diseases with an unfavorable prognosis. In a majority of patients, the transforming KIT mutation D816V is detectable. Currently, several drugs are available for the treatment of ASM/MCL, including midostaurin, a KIT D816V-targeting drug that has recently been approved for the treatment of advanced SM in the US and in Europe. However, when applied as single drug, midostaurin usually fails to induce durable remissions in patients with ASM/MCL, and the same holds true for all other drugs tested in the
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Gleixner, K. V., M. Mayerhofer, A. Vales, et al. "The Hsp32/HO-1-targeted drug SMA-ZnPP counteracts the proliferation and viability of neoplastic cells in solid tumors and hematologic neoplasms." Journal of Clinical Oncology 25, no. 18_suppl (2007): 14122. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.14122.

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14122 Background: Heat shock protein 32 (Hsp32) is a stress-related survival factor that is overexpressed in various neoplastic cells. Recently, specific Hsp32- targeting drugs such as styrene maleic acid encapsulated zinc protoporphyrin (SMA-ZnPP) have been developed. Methods: We examined the effects of SMA-ZnPP on proliferation and survival of various tumor cell-lines, including U97MG (glioblastoma), A549 (lung cancer), MDA-MB-231 (breast cancer), BxPC-3 (pancreatic), HepG2 (hepatocellular), Colo201, Colo320DM, DLD-1 (colon), OvCar3 (ovarian carcinoma), KG1, U937, HL60, K562 (myeloid leukemi
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Ubertini, Valentina, Stephanie French, James Wilson, and Frida Ponthan. "Abstract 374: Small intestinal organoids to study the effects of tight junction modulators that may improve the absorption of orally-administered, anti-neoplastic drugs." Cancer Research 82, no. 12_Supplement (2022): 374. http://dx.doi.org/10.1158/1538-7445.am2022-374.

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Abstract Although oral dosing is the most convenient route of drug administration, most anti-neoplastic drugs are administered intravenously due to poor bioavailability because of the epithelial barriers. A major organ involved in oral drug absorption is the small intestine where enterocytes are linked together by tight junctions (TJs). TJs regulate paracellular transport by creating a selectively-permeable barrier to small molecules, ions and water, thereby restricting the uptake of drugs. Transient modulation of the TJs is considered a potential strategy to improve drug delivery. Human small
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Hari, Dr Anupama, Dr Bushra Shereen, and Dr J. Sreeja Shraddha. "Anti-Neoplastic Drug Exposure in Pregnancy and Fetal Haemorrhage: A Rare Teratogenicity." Scholars International Journal of Obstetrics and Gynecology 5, no. 3 (2022): 130–32. http://dx.doi.org/10.36348/sijog.2022.v05i03.011.

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Anti-neoplastic drugs are known to have teratogenic effects on the fetus. In this case report we are presenting a case of a patient who got operated for breast carcinoma, conceived while on chemotherapy and underwent termination of pregnancy in the second trimester. Fetal haemorrhage and ecchymosis lead to further evaluation of the case, which revealed fetal thrombocytopenia, a rare teratogenic effect of the anti-neoplastic drugs.
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Wedeh, Ghaith, Emir Hadzijusufovic, Sabine Cerny-Reiterer, et al. "Bromodomain-Containing Protein 4 (BRD4): A Novel Marker and Drug Target Expressed In Neoplastic Cells In Advanced Mast Cell Neoplasms." Blood 122, no. 21 (2013): 3747. http://dx.doi.org/10.1182/blood.v122.21.3747.3747.

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Abstract Advanced mast cell (MC) neoplasms are characterized by uncontrolled growth and rapid expansion of neoplastic MC in various organ systems and a poor prognosis. In human patients, advanced systemic mastocytosis (SM) is rare and usually presents as aggressive SM (ASM) or mast cell leukemia (MCL). In canines, advanced MC tumors (MCT) are considered one of the most frequent skin tumors. Hence, so far, no effective treatment concept has been established for advanced MC neoplasms in humans or canines. This is due to the fact that neoplastic MC in advanced SM usually are resistant against var
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Dissertations / Theses on the topic "Neoplastic/drug effects"

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Näsman, Margareta. "Effects of anti-neoplastic therapy on tooth and bone formation : clinical and experimental studies /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-3282-4/.

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Castro, Rita de Cássia Borges de. "Efeito do ácido docosahexaenoico (DHA) sobre eventos epigenéticos em diferentes linhagens de câncer de mama." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-03102013-094648/.

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Alterações epigenéticas, como metilação do DNA e modificações pós traducionais em histonas, tem importante papel na carcinogênese mamária. A modulação de eventos epigenéticos constitui relevante alvo terapêutico, devido ao seu caráter reversível. Experimentalmente, o ácido docosahexaenoico (DHA), um membro da família dos ácidos graxos ômega-3, é capaz de diminuir proliferação, induzir morte celular e diminuir o potencial invasivo de células tumorais de mama. No entanto, os mecanismos antitumorais do DHA e sua capacidade de modular eventos epigenéticos ainda não estão totalmente elucidados. Nos
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Jackson, Sonya Grace. "Analysis of apoptosis levels in normal, inflamed and neoplastic colonic mucosa : the effects of non-steroidal anti-inflammatory drugs and 5-aminosalicylic acid on human colonic epithelial cell viability." Thesis, University of Leicester, 2004. http://hdl.handle.net/2381/29479.

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Numerous epidemiological, in vivo and in vitro studies have demonstrated the chemopreventive potential of NSAIDs, and it is thought that this chemoprevention may be due to the induction of apoptosis within malignant cells. The 5-aminosalicyclic acid (5-ASA) compounds are structurally similar to the NSAID aspirin, and have also been shown to reduce tumour growth in recent studies. There are a number of mechanisms by which this chemoprevention may occur, including inhibition of cyclooxygenase expression, induction of apoptosis through alterations in expression of the Bcl-2 family members, and ac
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Sales, Manuela Vasconcelos de Castro. "Efeitos cognitivos da quimioterapia adjuvante em pacientes com câncer de cólon." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-06042018-124633/.

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OBJETIVOS: Evidências consistentes sugerem que a quimioterapia (QT) sistêmica para o tratamento do câncer pode apresentar efeitos deletérios na cognição levando a prejuízos de memória, atenção, velocidade de processamento e função executiva. A maioria dos estudos anteriores, entretanto, foi realizada em mulheres com câncer de mama, o que levanta a possibilidade de que o déficit possa ter sido causado por alterações hormonais e/ou menopausa precoce induzidas pela QT. Pouco se sabe sobre a toxicidade da QT na cognição de pacientes portadores de câncer coloretal (CCR). O objetivo do estudo foi av
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Books on the topic "Neoplastic/drug effects"

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Fred, Nagelkerke J., Dierendonck Jan Hein van, and Noteborn Mathieu H. M, eds. Pharmaceutical intervention in apoptotic pathways. North-Holland Publishers, 1998.

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1947-, Koren Gideon, Lishner M, and Farine D, eds. Cancer in pregnancy: Maternal and fetal risks. Cambridge University Press, 1996.

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Wei, Dai, ed. Checkpoint responses in cancer therapy. Humana Press, 2008.

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E, Maragoudakis Michael, North Atlantic Treaty Organization. Scientific Affairs Division., and NATO Advanced Study Institute on Angiogenesis: Models, Modulators, and Clinical Applications (1997 : Rhodes, Greece), eds. Angiogenesis: Models, modulators, and clinical applications. Plenum Press, 1998.

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Ferner, Robin, and Anthony Cox. Drug-induced neurological disease. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0240.

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An adverse drug reaction is defined as ‘an appreciably harmful or unpleasant reaction, resulting from an intervention related to the use of a medicinal product; adverse effects usually predict hazard from future administration and warrant prevention, or specific treatment, or alteration of the dosage regimen, or withdrawal of the product’ (p. 1255, Edwards IR and Aronson JK. Adverse drug reactions: Definitions, diagnosis, and management. Lancet 2000; 356: 1255–9). Adverse drug reactions can cause or contribute to central and peripheral nervous system disorders, including traumatic, infective,
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Cohen, Gerry, and Ruth A. Roberts. Apoptosis in Toxicology. Taylor & Francis Group, 1999.

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Roberts, Ruth. Apoptosis in Toxicology. Taylor & Francis Group, 1999.

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Bisen, Prakash S., Zakir Khan, and Saurabh Bundela. Biology of Oral Cancer: Key Apoptotic Regulators. Taylor & Francis Group, 2013.

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Bisen, Prakash S., Zakir Khan, and Saurabh Bundela. Biology of Oral Cancer: Key Apoptotic Regulators. Taylor & Francis Group, 2013.

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Bisen, Prakash S. Biology of Oral Cancer: Key Apoptotic Regulators. Taylor & Francis Group, 2013.

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Book chapters on the topic "Neoplastic/drug effects"

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e Maria Qazi, Rida, Zahra Sajid, Chunqiu Zhao, Fawad Ur Rehman, and Afsar Ali Mian. "Nano Titania Applications in Cancer Theranostics." In Updates on Titanium Dioxide. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.111626.

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Titanium is one of the most abundantly utilized nanomaterials for human consumption. Biomedical applications of nano titania include sunscreens, drug delivery, prosthetic implants, bioimaging probes, and antimicrobial and antirheumatic agents for various treatment of diseases, including autoimmune disease, neurogenerative diseases, cardiovascular, musculoskeletal, and cancer. Its applications as a drug delivery vehicle and photosensitizer in cancer therapy and diagnosis are highly appreciated, especially for skin and natural cavities applications. The reactive oxygen species (i.e., H2O2, OH.,
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Hussain, Syed Faisal Jahir, Mohammed Adil A., Durga Munireddy, and Ashok Kumar Kumar Pandurangan. "Effects of Nigella sativa and Its Active Ingredient Thymoquinone on Breast Cancer." In Handbook of Research on Natural Products and Their Bioactive Compounds as Cancer Therapeutics. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-7998-9258-8.ch012.

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Breast cancer (BC) is the most prevalent malignancy in women. The main treatment for BC is surgery and chemotherapy. Generally, the chemotherapeutic drugs used for treatment cause numerous side effects. Substances derived from natural products have proven to exhibit anti-cancer effects without causing side effects. For instance, biochannin A found in cabbage and cauliflower reduced the growth of estrogen dependent MCF 7 cells. Another example is curcumin present in turmeric exhibits anti-proliferative and inhibitory effect against BC. The active compound of Nigella sativa is thymoquinone. The
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Alghamdi, Abdullah A. A., Amr Ahmed WalyEldeen, and Sherif Abdelaziz Ibrahim. "Nanoparticles as a Therapeutic Approach for Tumor Angiogenesis." In Innovative Approaches for Nanobiotechnology in Healthcare Systems. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-7998-8251-0.ch003.

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In cancer, angiogenesis is a hallmark necessary to supply sufficient nutrients for tumor growth and metastasis to distant sites. Therefore, targeting tumor angiogenesis emerges as an attractive therapeutic modality to retard neoplastic cell growth and dissemination using classes of anti-angiogenic drugs. However, multiple administrations of these drugs show adverse effects, precluding their long-term usage. Conventional chemotherapeutic drugs, natural compounds, carbon-based materials, inorganic and metallic elements, genes, siRNAs, shRNAs, and microRNAs can be incorporated into nanovehicles (
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Hadem, Khetbadei Lysinia Hynniewta, Lakhon Kma, Rajeshwar N. Sharan, and Arnab Sen. "Anticancer Effect of Aristolochia tagala and Curcuma caesia Acting Through Tumor Necrosis Factor-a." In Handbook of Research on Advanced Phytochemicals and Plant-Based Drug Discovery. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-6684-5129-8.ch019.

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This chapter begins with a brief description of the events associated with carcinogenesis such as what led a normal cell to transform into a pre-neoplastic one, their multiplication, and development into cancer. The authors also described how reactive oxygen species (ROS) are generated endogenously and from carcinogens, their role in carcinogenesis, and the link between inflammation and cancer. Elucidation of how cancer arises contributes to understanding the molecular mechanisms of action of some natural products. Herbal natural products contain metabolites that exert a physiological action o
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Rigatti, Patrizio, Avidgor Lev, Luigi Filippo Da Pozzo, Andrea Salonia, and Renzo Colombo. "Locally Induced Hyperthermia In Bladder Cancer." In Bladder Cancer. Oxford University PressNew York, NY, 1999. http://dx.doi.org/10.1093/oso/9780192630384.003.0022.

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Abstract For long time now local hyperthermia (LHT) has appeared to be a promisi.ng approach for treating solid tumours, particularly those located on the surface of the body or within a natural body cavity. Unfortunately, lack of a suitable and safe technology has prevented so far the implementation of this therapeutic solution. Based on advances in technology and on knowledge regarding the pathophysiology of the neoplastic diseases, recently acquired, many interesting clinical applications concerning hyperthermia alone or in combination with chemo- and/or radiotherapy in tumour ablation and
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Gluncic, Vicko. "Malignancy." In Basic Anesthesia Review, edited by Alaa Abd-Elsayed. Oxford University PressNew York, 2024. http://dx.doi.org/10.1093/med/9780197584569.003.0105.

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Abstract Approximately 40% of people have a chance to develop cancer during their lifetime, and two-thirds of these patients will undergo anesthesia and surgery. In perioperative care, special consideration should be paid to the patients receiving chemotherapy and/or radiation and/or immunotherapy due to side effects affecting different organ systems. In addition, paraneoplastic syndromes may accompany cancers and cause pathophysiologic disturbances. Anesthesia, surgery, and perioperative analgesia also have immunomodulatory effects and cause stress reaction—both of which can possibly contribu
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Martins, Daiane, Mitzy Stephanny Machado, Juliano Yasuo Oda, André Valério da Silva, Aline Rafaela da Silva Rodrigues Machado, and Alex Martins Machado. "THE IMMUNE CLOCK: HOW AGING REDUCES THE BODY'S DEFENSE AND HOW WE CAN SLOW IT DOWN." In Perspectives on Health: Knowledge for Life. Seven Editora, 2025. https://doi.org/10.56238/sevened2025.020-003.

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Immunosenescence is related to the gradual decline in immune system function associated with aging. This process contributes to increased susceptibility to infections, reduced vaccine response, and higher incidence of inflammatory and neoplastic diseases in the elderly. The main causative factors include quantitative and functional changes in T and B cells, accumulation of senescent cells, chronic low-grade inflammation ("inflammaging"), and imbalance in cytokine production. Advances in medicine have provided promising strategies for coping with this condition. Emerging clinical methods includ
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Kumar Soni, Vivek, Yashwant Kumar Ratre, Arundhati Mehta, et al. "Mushrooms Against Malignancies: from Chemosensitization to Immunopotentiation." In Mushrooms: A Wealth of Nutraceuticals and An Agent of Bioremediation. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815080568123010005.

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Malignancies have been among the diseases which claim most of the lives around the globe. They also impact the socioeconomic level as well as emotional detriments among the near and dear ones. Various strategies and interventions have been devised to combat these life-threatening conditions. The ill effects associated with synthetic drugs comprising most of the anticancer drugs enforce looking for an alternative source for molecules with therapeutic potential. Mushrooms are one of the most prominent sources of bioactive molecules with diverse medicinal properties. Various mushrooms have shown
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Chalco, Lorena, Robert Sánchez, Ana Guerrero, Guido Apolo, and Claudina Pires. "QUIMIOTERAPIA METRONÔMICA EM UM GATO COM CARCINOMA DE CÉLULAS ESCAMOSAS." In Ciência Animal e Veterinária: tópicos atuais em pesquisa - Volume 4. Editora Científica Digital, 2024. http://dx.doi.org/10.37885/230713907.

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Background: Squamous cell carcinoma (SCC) is a malignant neoplasm associated with prolonged exposure to ultraviolet light and lack of skin pigment in white-coated animals. The disease diagnosis is based on the animal's history, clinical signs and histopathology of the samples collected. The therapeutic alternatives are diverse. Among them, one of the most used is the metronomic chemotherapy which is based on the use of cytostatics drugs, applied in low and frequent doses for a longer period of time. One of the mechanisms of action of this type of therapy is the decrease in angiogenesis. Non-st
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Alonazi, Noufa, Talat Abdullah Albukhari, and Naif M. Alruwaili. "Nanotechnology and Precision Medicine." In Molecular Targets and Cancer Therapeutics (Part 2). BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815124606123010008.

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Nanoscience and Nanotechnology are now almost in every field of Science. The field has been growing since it was started in 1959 when the Nobel Prize American physicist, Richard Feynman introduced the concept of nanotechnology; since then, it has involved in almost every field of Science, including chemistry, biology, computer science, physics, and engineering. Nanoscience and nanotechnology are now at the frontline of modernistic research. The term nano referred to a Greek prefix meaning “dwarf” with a scale of one thousand millionths of a meter (10-9 m). Nanoscience is the study of particles
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Conference papers on the topic "Neoplastic/drug effects"

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Pâslaru, Ana Maria, Ana Maria Fătu, Alexandru Nechifor, Laura Florentina Rebegea, Diana Bulgaru Iliescu, and Anamaria Ciubara. "PSYCHO-ONCOLOGY. CASE PRESENTATION." In The European Conference of Psychiatry and Mental Health "Galatia". Archiv Euromedica, 2023. http://dx.doi.org/10.35630/2022/12/psy.ro.35.

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Increased survival of oncology patients brings to attention new aspects of adverse effects due to antineoplastic treatment. Psychiatric disorders, cardiovascular disorders as well as the progressive incidence of multiple primary neoplasia are some of the most common side effects. Aim: Care of the oncology patient undergoes an important period of change, from the management of tumor disease to the multidisciplinary approach, centered on improving the quality of life. Method: We present the case of a 75-year-old patient, whose personal pathological history reveals the presence of a diagnosis of
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Ditto, Andrew J., Nikki K. Robbishaw, Matthew J. Panzner, Wiley J. Youngs, and Yang H. Yun. "Targeting Ovarian Cancer Cells With Rapidly Biodegradable L-Tyrosine Polyphosphate Nanoparticles Decorated With Folate." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53138.

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Chemotherapy employs toxic chemicals to kill rapidly dividing cells. Examples of FDA approved antineoplastic drugs include cisplatin, doxorubicin, and paclitaxel. Since most of these drugs are nonspecific, they also damage normal tissues as well as the aberrant tumors. As a result, non-specific therapies have multiple side effects, which include myelosuppression, mucositis, alopecia, nephrotoxicity, and genotoxcity. In order to minimize these issues, researchers have begun to conjugate antineoplastic chemicals with targeting moieties or encapsulate drugs into nanoparticles decorated with compo
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Lima, Paula Marynella Alves Pereira, Douglas Cardoso Brandão, Raquel Pereira Cruz, et al. "A NEW COPPER TERNARY COMPLEX IS A PROMISED COMPOUND FOR THE TREATMENT OF TRIPLE-NEGATIVE BREAST CANCER." In Abstracts from the Brazilian Breast Cancer Symposium - BBCS 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s2011.

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Objectives: Triple-negative breast cancer (TNBC) is a biologically aggressive tumor with poor prognosis due to the lack of effective therapeutic strategies. Although chemotherapy is widely employed, chemoresistance and severe side effects remain a challenge in controlling this breast cancer subtype. Doxorrubicin (DOX) and platinum-based drugs are commonly used in oncological regimens but with limitations. In this scenario, metallodrugs based on copper element have been emerged as novel and promised compounds, due to the presenting mechanisms of action and biodistribution different from the pla
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Moura, Fernanda Maria Gonçalves de Sousa, Bruno Rezende Trindade Borges, Davi Vargas Freitas Teixeira, and Roberta Arb Saba Rodrigues Pinto. "Phenytoin-induced Chorea: a case report." In XIV Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s1.392.

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A 67-years-old woman, with no significant medical history, presents herself at Hospital do Servidor Público do Estado de São Paulo after a seizure episode following two weeks of a moderate heat trauma at home. At initial evaluation, no neurological deficit was found, but computed tomography showed a mild subdural hemorrhage in the left frontal area that was promptly drained. The patient was discharged with oral phenytoin 100 mg each eight hours. After thirty days, the patient returns to the hospital reporting the progressive onset of involuntary abnormal movements of upper limbs and head, asso
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