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Journal articles on the topic 'Nephroprotective Activity [1]'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Bhusnar, Hanumant, Sushil Patil, Soma Das, and Laxmikant Borse. "Network Pharmacology Approach to Evaluate the Therapeutic Effects of Caesalpinia bonduc (L.) Components for the Nephroprotective Activity." Innovation of Chemistry & Materials for Sustainability 2, no. 1 (2025): 23–31. https://doi.org/10.63654/icms.2025.02023.

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Caesalpinia bonduc (L.) (Family: Caesalpiniaceae) commonly known as Bonduc Nut and Fever Nut is the main ingredients in Hjam-hbras formulation, a single herb formulation documented in Buddha Shakamuni for treating renal diseases. C. bonduc seed extract is also scientifically validated for having renal protective effects but its exact mechanism by which it showed renal protective effect is still unknown. In this study, we aimed to evaluate the nephroprotective mechanism of action of C. bonduc seed by performing Network pharmacology analysis. ADMET property analysis reveals 21 out of 190 phytoch

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Afroz, Mehdi and Dr. Fazil ahmad. "NEPHROPROTECTIVE ACTIVITYOF ACORUS CALAMUS LEAVES EXTRACT AGAINST LITHIUM INDUCED NEPHROTOXICITY IN WISTAR RATS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 04 (2018): 3132–43. https://doi.org/10.5281/zenodo.1237980.

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Acorus calamus is a tall perennial herb. It is a wetland monocot of the Acoraceae family, in the genus Acorus.It is also called sweet flag or calamus. Sweet Sedge is 30 to 100 cm tall. Tufts of basal leaves arises from a spreading rhizome. Calamus is used as sedative, diuretic, laxative and as a carminative agent in modern herbal science medicines. Its use in siddha and ayurvedic medicine is also reported where in stems, leaves, roots, barks plays magnificent role. Few uses approved for calamus is as a flavour for pipe tobacco from the rhizome essence and is also used as essential oil in perfu

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Aljutaily, Thamer, Sarah M. Almutairi, and Hend F. Alharbi. "The Nephroprotective Potential of Brassica nigra Sprout Hydroalcoholic Extract against Carbon Tetrachloride-Induced Renal Toxicity in Rats." Foods 12, no. 21 (2023): 3906. http://dx.doi.org/10.3390/foods12213906.

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The nephroprotective potential of the Brassica nigra sprout (BNS) hydroalcoholic extract against carbon tetrachloride (CCl4)-induced renal toxicity in rats was the object of this study. B. nigra sprouts were prepared in the lab to monitor the bio-changes in bioactive compounds during the sprouting for up to 7 days at 17 ± 1 °C and 90% relative humidity. Subsequently, 6-day sprouts of B. nigra were selected according to their phenolics and antioxidant activity, extracted, and examined for their nephroprotective and antioxidative stress potential at 250 and 500 mg sprout extracts kg−1 bw, in viv

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Afjal, MA, SA Hasan Abdi, S. Sharma, et al. "Anti-inflammatory role of tempol (4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl) in nephroprotection." Human & Experimental Toxicology 38, no. 6 (2019): 713–23. http://dx.doi.org/10.1177/0960327119836203.

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Inflammation is one of the mechanisms involved in the acute kidney injury (AKI) caused by cisplatin (CP)-induced nephrotoxicity. Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl) has powerful antioxidant activity. We investigated its potential nephroprotective effects and the underlying mechanisms that may add further benefits to its clinical usefulness in a CP-induced AKI model. Male Swiss albino mice were divided randomly into four groups: control, CP (20 mg/kg intraperitoneally), tempol (100 mg/kg/day, per os) + CP, and tempol only treatments. Blood samples were collected to analyze re

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Rosnizar, Nyoman Ehrich Lister I, Edy Fachrial, Shahna, and Sukirman Lie. "Nephroprotective effect of mengkudu (Morinda citrifolia) on rats induced by doxorubicin." Journal of Inventions in Biomedical and Pharmaceutical Sciences 5, no. 2 (2020): 10–17. http://dx.doi.org/10.26452/jibps.v5i2.1437.

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Chronic kidney disease in the world is currently experiencing an increase and become a serious health problem. Doxorubicin clinical efficacy is hampered by dose-related organotoxic (heart, liver, and kidney) potential. The purpose of this study was to determine the nephroprotective activity of mengkudu fruit ethanol extract against the rats induced by doxorubicin. Mengkudu fruit ethanol extract was obtained by maceration. Nephroprotective activity test is done by measuring urea and creatinine. Animals were induced with doxorubicin (DOX) 5 mg/kgbw on day 1, 7, 14 and 20th. Administration of men

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Rosita, Rosita, Yuandani Yuandani, and Marianne Marianne. "NEPHROPROTECTIVE ACTIVITY OF ETHANOL EXTRACT OF CURCUMA MANGGA VAL. IN PARACETAMOL-INDUCED MALE MICE." Asian Journal of Pharmaceutical and Clinical Research 11, no. 13 (2018): 126. http://dx.doi.org/10.22159/ajpcr.2018.v11s1.26585.

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Objective: This study aimed to evaluate nephroprotective activity of Curcuma mangga in paracetamol-induced male mice.Methods: Male mice were divided into several groups including normal control, negative, positive, and treatment groups. Treatment groups were orally administered with C. mangga extract at doses of 100, 200, and 400 mg/kg bw for 7 days. On day 7after 1 h of treatment, the mice were induced with paracetamol 1.05 g/kg bw. Serum creatinine level measurement and histopathotlogy study were performed at the end of experiment.Results: C. mangga extract was able to inhibit the increase o

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Zhou, Lu, Peng Yu, Ting-ting Wang, et al. "Polydatin Attenuates Cisplatin-Induced Acute Kidney Injury by Inhibiting Ferroptosis." Oxidative Medicine and Cellular Longevity 2022 (January 15, 2022): 1–14. http://dx.doi.org/10.1155/2022/9947191.

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Cisplatin is widely used in the treatment of solid tumors, but its application is greatly limited due to its nephrotoxicity; thus, there is still no effective medicine for the treatment of cisplatin-induced acute kidney injury (Cis-AKI). We previously identified that polydatin (PD) exerts nephroprotective effects by antioxidative stress in AKI models. Recent evidence suggests that oxidative stress-induced molecular events overlap with the process of ferroptosis and that there are common molecular targets, such as glutathione (GSH) depletion and lipid peroxidation. Nevertheless, whether the nep

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Shiyan, Shaum, Herlina Herlina, and Lita Rizkika Sari. "NEPHROPROTECTIVE OF ANTHOCYANIN PIGMENTS EXTRACT FROM RED CABBAGE (BRASSICA OLERACEA L. VAR. CAPITATA F. RUBRA) AGAINST GENTAMICIN-CAPTOPRIL-INDUCED NEPHROTOXICITY IN RATS." Asian Journal of Pharmaceutical and Clinical Research 11, no. 4 (2018): 432. http://dx.doi.org/10.22159/ajpcr.2018.v11i4.20373.

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Objective: Red cabbage (Brassica oleracea L. var. Capitata f. rubra) has a fairly high anthocyanin content and is a source of powerful antioxidants. This study is basic for the development of a nutraceutical, which has nephroprotective activity.Methods: Red cabbage was extracted using ethanol and water with a mixture of citric acid with a variation of 1, 2, and 3%. The total anthocyanin was determined with pH-differential method. The Wistar strain male rats were divided into five groups. Group 1 as a negative control, Group 2 as a positive control treated with Vitamin E dose of 400 mg/kg BW da

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Heeba, Gehan H., Marwa A. M. Ali, and Azza A. K. El-Sheikh. "Rosuvastatin Induces Renal HO-1 Activity and Expression Levels as a Main Protective Mechanism against STZ-Induced Diabetic Nephropathy." Medicina 58, no. 3 (2022): 425. http://dx.doi.org/10.3390/medicina58030425.

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Background and Objectives: Nephroprotective effect of statins is still controversial. The aim of this study was to investigate the possible hemin-like nephroprotective effect of rosuvastatin (RSV) in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: DN was induced in rats via a single dose of 50 mg/kg STZ i.p., with or without RSV (10 mg/kg orally) for 30 days. To investigate hemin-like effect of RSV on renal heme oxygenase-1 (HO-1), RSV was administered in the presence or absence of an inhibitor of HO-1; zinc protoporphyrin-XI (ZnPP), in a dose of 50 µmol/kg i.p. Results: Ind

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Sultana, Mst Shahin, Rekha Rani Saha, Sheikh Nazrul Islam, Tasnin Afrin, Rumana Afroz, and Mahbuba Jahan Lotus. "Nephroprotective Activity of Aqueous Extract of Carica Papaya Seeds in Carbon Tetrachloride Induced Nephrotoxic Rats." Ibrahim Cardiac Medical Journal 12, no. 1 (2023): 9–17. http://dx.doi.org/10.3329/icmj.v12i1.69540.

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Background & objective: The kidney plays a dominant role in homeostasis by excreting the metabolic waste products and excess of necessary substances. It is a major excretory organ regulating water and electrolyte balance and conserving necessary products according to body needs. Nephrotoxicity is one of the most common kidney problems. A number of therapeutic agents can adversely affect the kidney resulting in acute renal failure, chronic interstitial nephritis and nephritic syndrome. Nephroprotective agents are the substances which possess protective activity against Nephrotoxicity. Early

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Nikitha Suvarna J, Amrita Parida, Basavaraj Poojar, Sumanjali Daggupati, Manju V, and Rashmi R. Rao. "Nephroprotective activity of Sinapis alba in gentamicin induced murine model of renotoxicity." International Journal of Research in Pharmaceutical Sciences 10, no. 4 (2019): 3761–67. http://dx.doi.org/10.26452/ijrps.v10i4.1766.

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Sinapis alba, belongs to the family Brassicaceae and is known to possess an antioxidant capacity. Based on this background, this study was planned to look for the nephroprotective activity of Sinapis alba seed extract against nephrotoxicity caused by gentamicin in rats. Sinapis alba seeds were dried in the shade and then powdered. Then, the powder was subjected to extraction with 95% ethanol and brought to a syrup consistency by distilling the solvent and reducing the pressure using a water bath. Animals were divided into four groups. Each group had six animals in it. Group 1 serves as normal

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Bubnova, M. G. "ARB I olmesartan interruption in cardiovascular and cardiorenal continuum: antihypertensive and nephroprotective effects (part 1)." CardioSomatics 5, no. 3-4 (2014): 32–40. http://dx.doi.org/10.26442/cs45121.

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The article provides an overview of the efficacy and tolerability of one of the representatives of the class angiotensin receptor blockers II - olmesartan medoxomil (Kardosal). Analyzed are the characteristics and pharmacological activity of olmesartan medoxomil antihypertensive monotherapy, in combination with other antihypertensive drugs, in different groups of patients. The article describes the renal protective properties of the drug, its safety profile. It also discusses the reasons for poor adherence therapy in patients with arterial hypertension.

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Svyrydova, N. K. "Why carnitine deficiency is relevant in the treatment of patients with neurological disorders." East European Journal of Neurology, no. 1(1) (March 20, 2015): 33–38. http://dx.doi.org/10.33444/2411-5797.2015.1(1).33-38.

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L-carnitine holds an important place among the medicines that affect the metabolism,. Carnitine-based medications are highly effective and can seriously contribute to a regression of clinical manifestations of the disease or decrease the intensity of the disease. The metabolic activity of Cardonat Sperco Ukraine, the anabolic properties of its components, as well as their cardio-, neuro-, and hepato¬ and nephroprotective properties give reason to consider Cardonat it the first polyprotector anabolic. All of the above makes it possible to use Cardonat in cardio-neurological, gastroenterological

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Aslam, Mohammad, Mohammed Ali, Rameshwar Dayal, and Kalim Javed. "Coumarins and a Naphthyl Labdanoate Diarabinoside from the Fruits of Peucedanum grande C. B. Clarke." Zeitschrift für Naturforschung C 67, no. 11-12 (2012): 580–86. http://dx.doi.org/10.1515/znc-2012-11-1208.

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Phytochemical investigations of the methanolic extract of the fruits of Peucedanum grande C. B. Clarke (Apiaceae) led to the identification of three coumarins and a naphthyl labdanoate diarabinoside characterized as 5-hydroxy-6-isopranyl coumarin (1), 5,6-furanocoumarin (2), 7-methoxy-5,6-furanocoumarin (3), and labdanyl-3α-ol-18-(3’’’-methoxy-2’’’- naphthyl-oate)-3α-L-arabinofuranosyl-(2’→1’’)-α-L-arabinofuranoside (4). The structures of these compounds were identified on the basis of spectral data analysis and chemical reactions. The methanolic extract and 4 showed nephroprotective activity

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Barakat, Hassan, Ibrahim Ali Alkabeer, Sami A. Althwab, et al. "Nephroprotective Effect of Fennel (Foeniculum vulgare) Seeds and Their Sprouts on CCl4-Induced Nephrotoxicity and Oxidative Stress in Rats." Antioxidants 12, no. 2 (2023): 325. http://dx.doi.org/10.3390/antiox12020325.

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Functional and nutritional characteristics of seed sprouts and their association with oxidative stress-related disorders have recently become a focus of scientific investigations. The biological activities of fennel seeds (FS) and fennel seed sprouts (FSS) were investigated in vitro and in vivo. The total phenolic content (TPC), total flavonoids (TF), total flavonols (TFF), and antioxidant activity (AOA) of FS and FSS were examined. HPLC and GC–MS analyses for FS and FSS were carried out. Consequently, the nephroprotective and antioxidative stress potential of FS and FSS extracts at 300 and 60

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Abdel-Kader, Maged S., and Saleh I. Alqasoumi. "In Vivo Hepatoprotective and Nephroprotective Activity of Acylated Iridoid Glycosides from Scrophularia hepericifolia." Biology 10, no. 2 (2021): 145. http://dx.doi.org/10.3390/biology10020145.

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Phytochemical investigation of the chloroform fraction obtained from Scrophularia hypericifolia aerial parts led to the isolation of nine acylated iridoid glycosides. The new compounds were identified as 6-O-α-L(2″-acetyl, 3″,4″-di-O-trans-cinnamoyl) rhamnopyranosyl-6′-acetyl catalpol (6′-acetyl hypericifolin A) (1), 6-O-α-L(2″, 4″-diacetyl, 3″-O-trans-cinnamoyl) rhamnopyranosyl-6′-acetyl catalpol (6′-acetyl hypericifolin B) (2), 6-O-α-L(2″-acetyl, 3″,4″-di-O-trans-cinnamoyl) rhamnopyranosyl catalpol (hypericifolin A) (3) and 6-O-α-L(2″, 4″-diacetyl, 3″-O-trans-cinnamoyl) rhamnopyranosyl catal

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Hasan, Abdulhakeem, Reem Issa, Lidia Al-Halaseh, Manal A. Abbas, Nariman Al-Jawabri, and Rawan Al-Suhaimat. "Investigation of the nephroprotective activity of Moringa peregrina leaves aqueous extract in mice." Pharmacia 69, no. 4 (2022): 1095–102. http://dx.doi.org/10.3897/pharmacia.69.e90506.

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Traditional remedies for Moringa peregrina leaves have a variety of uses with confirmed biological and therapeutic effects, as per published reports. The current study aims to evaluate the ability of the leaves aqueous extract to protect from nephrotoxicity in gentamicin-treated mice. Phytochemical analysis for the aqueous extract was performed using DPPH (2,2-Diphenyl-1-picrylhydrazyl) assay for antioxidants, Folin-Ciocalteu, AlCl3 and HPLC- MS/MS analysis, focusing on phenol and flavonoid content. The nephroprotective activity of the prepared extract was evaluated by means of variable bioche

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Hasan, Abdulhakeem, Reem Issa, Lidia Al-Halaseh, Manal A. Abbas, Nariman Al-Jawabri, and Rawan Al-Suhaimat. "Investigation of the nephroprotective activity of Moringa peregrina leaves aqueous extract in mice." Pharmacia 69, no. (4) (2022): 1095–102. https://doi.org/10.3897/pharmacia.69.e90506.

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Traditional remedies for Moringa peregrina leaves have a variety of uses with confirmed biological and therapeutic effects, as per published reports. The current study aims to evaluate the ability of the leaves aqueous extract to protect from nephrotoxicity in gentamicin-treated mice. Phytochemical analysis for the aqueous extract was performed using DPPH (2,2-Diphenyl-1-picrylhydrazyl) assay for antioxidants, Folin-Ciocalteu, AlCl<sub>3</sub> and HPLC- MS/MS analysis, focusing on phenol and flavonoid content. The nephroprotective activity of the prepared extract was evaluated by means of vari

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Naushad, Mohd, Mohd Urooj, Tasleem Ahmed, et al. "NEPHROPROTECTIVE EFFECT OF TUKHME KARAFS (APIUM GRAVEOLENS L.) AGAINST GENTAMICIN INDUCED NEPHROTOXICITY IN EXPERIMENTAL ANIMALS." INDIAN DRUGS 57, no. 07 (2020): 63–69. http://dx.doi.org/10.53879/id.57.07.12276.

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Tukhme Karafs is the seed of Apium graveolens L., which is an important aromatic plant grown globally as a fresh herb and widely used as salad crop. This seed possesses potential pharmacological activity like hepatoprotective, diuretic and lithotriptic. The present study was designed to evaluate nephroprotective effect of Tukhme Karafs against gentamicin (80 mg/kg BW) induced nephrotoxicity in male Wistar rats. The effect was tested at two dose levels i.e. 500 mg/kg and 1000 mg/kg BW (calculated based on clinical dose mentioned in Unani literature). The study was divided into curative and prot

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Hui, Wu, Yuan Yongliang, Chen Yongde, et al. "Hypouricemic and Nephroprotective Effects of Emodinol in Oxonate-Induced Hyperuricemic Mice are Mediated by Organic Ion Transporters and OIT3." Planta Medica 82, no. 04 (2015): 289–97. http://dx.doi.org/10.1055/s-0035-1558212.

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AbstractEmodinol, 1β,3β,23-trihydroxyolean-12-en-28-acid, as the main active ingredient firstly extracted from the rhizomes of Elaeagus pungens by our research group, has been demonstrated to exhibit uricosuric activity by our previous study. The aim of this study was to evaluate the uricosuric and nephroprotective effects of emodinol and explore its possible mechanisms in potassium oxonate-induced hyperuricemic mice with renal dysfunction. Mice were orally administrated 250 mg/kg of potassium oxonate once daily for 7 consecutive days to induce hyperuricemia with renal dysfunction. Emodinol wa

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Uhrinová, A., and N. Poľančíková. "Antioxidant Activity of the Fungus Cordyceps sinensis Grown on Two Different Media." Folia Veterinaria 62, no. 3 (2018): 68–73. http://dx.doi.org/10.2478/fv-2018-0030.

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Abstract Cordyceps sinensis, a species of the genus Ascomycetes, is recognised as the most famous tonic herb and natural remedy in traditional Chinese medicine for centuries. Various pharmacological actions of the chemical constituents of C. sinensis have been reported, including: antitumour effects, hepatoprotective and anti-inflammatory effects, and antioxidant, nephroprotective and anti-apoptotic properties. In this study we tested the antioxidant activity of extracts of the fungus C. sinensis grown on two subspecies of rice, Oryza sativa var. Indica and Oryza sativa var. Japonica. The extr

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Zrouri, Hassan, Amine Elbouzidi, Mohamed Bouhrim, et al. "Phytochemical analysis, antioxidant activity, and nephroprotective effect of the Raphanus sativus aqueous extract." Mediterranean Journal of Chemistry 11, no. 1 (2021): 84. http://dx.doi.org/10.13171/mjc02101211565lk.

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<p class="Default">In Morocco, Raphanus sativus is a widespread traditional medicinal plant used to treat various kidney diseases such as nephropathy.</p><p class="Mabstract"><strong>Objective</strong>:<strong> </strong>The present study aims to evaluate the protective effect of the <em>R. sativus </em>aqueous extract against the gentamicin-induced acute nephrotoxicity in rats.</p><p class="Mabstract"><strong>Methods</strong>: Rats were randomly separated into four groups (n=6; ♂/ ♀=1). The control group was treated

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Sinaeve, Sébastien, Cécile Husson, Marie-Hélène Antoine, Stéphane Welti, Caroline Stévigny, and Joëlle Nortier. "Nephroprotective Effects of Two Ganoderma Species Methanolic Extracts in an In Vitro Model of Cisplatin Induced Tubulotoxicity." Journal of Fungi 8, no. 10 (2022): 1002. http://dx.doi.org/10.3390/jof8101002.

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Although cisplatin is used as a first-line therapy in many cancers, its nephrotoxicity remains a real problem. Acute kidney injuries induced by cisplatin can cause proximal tubular necrosis, possibly leading to interstitial fibrosis, chronic dysfunction, and finally to a cessation of chemotherapy. There are only a few nephroprotective actions that can help reduce cisplatin nephrotoxicity. This study aims to identify new prophylactic properties with respect to medicinal mushrooms. Among five Ganoderma species, the methanolic extracts of Ganoderma tuberculosum Murill., Ganoderma parvigibbosum We

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Ali Haimoud, Safia, Rachida Allem, Meriem Medjekane, et al. "Antispasmodic and nephroprotective potentials of native Algerian propolis and bee pollen: An experimental study in mice." International Food Research Journal 30, no. 1 (2023): 109–18. http://dx.doi.org/10.47836/ifrj.30.1.08.

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The present work examined the in vivo antispasmodic and nephroprotective potentials of methanolic extracts obtained from Algerian native propolis and bee pollen. The in vivo antispasmodic activity was assessed by the intraperitoneal injection of acetic acid (1%) which induced long-lasting visceral pain in mice. The renal damage was modelled by intraperitoneal injection of a cisplatin (CP; 10 mg/kg) followed by histopathological changes in kidneys. In addition, the beehive by-products were screened for their bioactive content and in vitro antioxidant activities. The propolis and bee pollen are

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Ansar, S., and M. Iqbal. "Antioxidant and nephroprotective potential of butylated hydroxyanisole against ferric nitrilotriacetate-induced oxidative stress and early tumor events." Human & Experimental Toxicology 35, no. 4 (2015): 448–53. http://dx.doi.org/10.1177/0960327115591378.

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The present study was aimed to study protective effect of butylated hydroxyanisole (BHA), a phenolic antioxidant used in foods on ferric nitrilotriacetate (Fe-NTA)–induced nephrotoxicity. Male albino rats of Wistar strain (4–6 weeks old) weighing 125–150 g were used in this study. Animals were given a single dose of Fe-NTA (9 mg kg−1 body weight) after treatment with BHA (1 and 2 mg animal−1 day−1). Fe-NTA treatment enhanced ornithine decarboxylase (ODC) activity to 5.3-fold, and [3H]-thymidine incorporation in DNA to 2.5-fold in kidney compared with the corresponding saline-treated control, w

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Alaaeldin, Rania, Sally M. Bakkar, Reham H. Mohyeldin, Fares E. M. Ali, Nehad M. Reda Abdel-Maqsoud та Moustafa Fathy. "Azilsartan Modulates HMGB1/NF-κB/p38/ERK1/2/JNK and Apoptosis Pathways during Renal Ischemia Reperfusion Injury". Cells 12, № 1 (2023): 185. http://dx.doi.org/10.3390/cells12010185.

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Renal ischemia/reperfusion (IR) injury is characterized by an unexpected impairment of blood flow to the kidney. Azilsartan is an angiotensin receptor blocker that is approved for the management of hypertension. The present study aimed to investigate, on molecular basics, the nephroprotective activity of azilsartan on renal IR injury in rats. Rats were assigned into four groups: (1) Sham group, (2) Azilsartan group, (3) IR group, and (4) IR/Azilsartan-treated group. Histological examination and renal function were evaluated. Levels of KIM-1, HMGB1, caspase 3, GPX, SOD, NF-κB, and p53 proteins

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Prasanth, Dsnbk, Lingala Siva Sankar Reddy, Tharani Dasari, et al. "LC/MS-Based Profiling of Hedyotis aspera Whole-Plant Methanolic Extract and Evaluation of Its Nephroprotective Potential against Gentamicin-Induced Nephrotoxicity in Rats Supported by In Silico Studies." Separations 10, no. 11 (2023): 552. http://dx.doi.org/10.3390/separations10110552.

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Many high-altitude plants, such as Hedyotis aspera, need to be explored for their possible medicinal value. The current study explored the protective effect of Hedyotis aspera methanolic extract whole plant (HAME) against gentamicin-induced nephrotoxicity in rats. It profiled their phytocontents using HPLC-QTOF-MS/MS analytic methods. The LC-MS analysis of HAME revealed 27 compounds. Eight compounds followed Lipinski’s rule of five and were found to be potential TNF-α inhibitors with binding affinities of −6.9, −6.3, −6.3, and −6.3 Kcal/mol, such as 14,19-Dihydroaspidospermatine, coumeroic aci

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Yoon, Joobyoung, Hyunyong Lee, Hwan Bong Chang та ін. "DW1029M, a novel botanical drug candidate, inhibits advanced glycation end-product formation, rat lens aldose reductase activity, and TGF-β1 signaling". American Journal of Physiology-Renal Physiology 306, № 10 (2014): F1161—F1170. http://dx.doi.org/10.1152/ajprenal.00651.2013.

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DW1029M is a botanical extract consisting of Morus bark and Puerariae radix, produced by Dong-Wha Pharmaceutical, for nephroprotective drug development; it has been in phase II clinical trials in Korea. In our mechanistic investigations, we found that DW1029M inhibits advanced glycation end products (AGEs), rat lens aldose reductase (RLAR), and transforming growth factor (TGF)-β1 signaling, all of which are implicated in diabetic complications such as diabetic nephropathy and diabetic retinopathy. DW1029M inhibits AGE formation via Fe2+ chelation. The extract contains 13 active constituents th

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Egbuonu, Anthony C. C., Prince O. Alaebo, Chiemeziem A. Obike, et al. "Antioxidant and Nephroprotective Studies on Telfairia occidentalis Pod in Experimental Rats." Nigerian Journal of Biochemistry and Molecular Biology 39, no. 2 (2024): 99–105. http://dx.doi.org/10.4314/njbmb.v39i2.9.

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Monosodium glutamate (MSG) induces nephrotoxicity accompanied with oxidative stress at high dose (8000 mg/kg). Medicinal prospects of underutilized Telfairia occidentalis pod, TOP was suggested recently. This study investigated the in vitro antioxidant potentials, and in vivo antioxidant, renal function and histologic outcomes of TOP extract, TOPE, in MSG-challenged rats after oral exposure for 14 days. In vitro, ferric reducing antioxidant power (FRAP), total antioxidant capacity (TAC) and 2,2-diphynyl-1-picrylhydrazyl (DPPH) scavenging activity of TOPE concentration-dependently peaked at the

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Dezoti Fonseca, Cassiane, Mirian Watanabe, and Maria de Fátima Fernandes Vattimo. "Role of Heme Oxygenase-1 in Polymyxin B-Induced Nephrotoxicity in Rats." Antimicrobial Agents and Chemotherapy 56, no. 10 (2012): 5082–87. http://dx.doi.org/10.1128/aac.00925-12.

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ABSTRACTPolymyxin B (PMB) is a cationic polypeptide antibiotic with activity against multidrug-resistant Gram-negative bacteria. PMB-induced nephrotoxicity consists of direct toxicity to the renal tubules and the release of reactive oxygen species (ROS) with oxidative damage. This study evaluated the nephroprotective effect of heme oxygenase-1 (HO-1) against PMB-induced nephrotoxicity in rats. Adult male Wistar rats, weighing 286 ± 12 g, were treated intraperitoneally once a day for 5 days with saline, hemin (HO-1 inducer; 10 mg/kg), zinc protoporphyrin (ZnPP) (HO-1 inhibitor; 50 μmol/kg, admi

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Rojano Toimil, Alba, and Andreea Ciudin. "GLP-1 Receptor Agonists in Diabetic Kidney Disease: From Physiology to Clinical Outcomes." Journal of Clinical Medicine 10, no. 17 (2021): 3955. http://dx.doi.org/10.3390/jcm10173955.

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Diabetic kidney disease (DKD) is one of the most common complications in type 2 diabetes mellitus (T2D) and a major cause of morbidity and mortality in diabetes. Despite the widespread use of nephroprotective treatment of T2D, the incidence of DKD is increasing, and it is expected to become the fifth cause of death worldwide within 20 years. Previous studies have demonstrated that GLP-1 receptor agonists (GLP-1 RA) have improved macrovascular and microvascular outcomes independent of glycemic differences, including DKD. GLP-1Ras’ improvement on kidney physiology is mediated by natriuresis, red

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SEKEDE ET AL, Kodjovi Dovi. "In vitro antioxidant, anti-inflammatory and ex vivo nephroprotective activities of Chenopodium ambrosioides." International Journal of Pharmaceutical, Physico-chemical and Nutritional Analysis 1, no. 2 (2023): 9–15. http://dx.doi.org/10.61585/ucad-ijppna-v1i203.

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Chenopodium ambrosioides is a medicinal plant used in Togo to treat nephropathy and other diseases. The present study was undertaken to evaluate the in vitro antioxidant and anti-inflammatory capacity and the ex vivo nephroprotective capacity of Chenopodium ambrosioides extract. Antioxidant potential was determined in vitro by 2,2-Diphenyl-1-picrylhydrazyl (DPPH) scavenging, total antioxidant capacity and reducing power tests. Egg albumin denaturation and membrane stabilization tests were carried out to assess its anti-inflammatory effect. The ex vivo nephroprotective activity of the extract w

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oboh, Ganiyu, Adedayo O. Ademiluyi, and Ayodele J. Akinyemi. "Inhibitory Effect of Phenolic Extract from Garlic on Angiotensin-1 Converting Enzyme and Cisplatin induced Lipid Peroxidation - In Vitro." International Journal of Biomedical Science 9, no. 2 (2013): 98–106. http://dx.doi.org/10.59566/ijbs.2013.9098.

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Allium sativum have been an important food ingredient in the management or treatment of renal disease. Therefore, this study sought to determine the inhibitory effect of phenolic-rich extract from A. sativum on angiotensin 1 converting enzyme (ACE) activity (key enzyme linked to renal dysfunction) and cisplatin-induced lipid peroxidation in rat kidney in vitro. The free phenolics were extracted with 80% acetone, while the bound phenolics were extracted from the alkaline and acid hydrolyzed residue with ethyl acetate. Thereafter, their inhibitory effect on angiotensin 1 converting enzyme (ACE)

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Nair, Dhanya Renuka, and Ansary PY. "Nephroprotective effect of the combination of Nisha and Amalaki in Alloxan-induced hyperglycaemic rats." International Journal of Ayurvedic Medicine 15, no. 4 (2025): 1158–65. https://doi.org/10.47552/ijam.v15i4.5165.

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Background: Experimental studies have shown that Nisha (Curcuma longa L) rhizomes and Amalaki (Phyllanthus emblica L) fruits possess antidiabetic, antioxidant and nephroprotective activity. Their combination is effective in Type-2 Diabetes. The present study was an attempt to assess the nephroprotective activity of the combination of powder of Nisha rhizomes and Amalaki fruits in alloxan induced hyperglycaemic albino rats. Methods: The in-vivo study was conducted at the facility in Govt. Ayurveda College, Thiruvananthapuram. Wistar rats of both sexes weighing 150-200 gm were induced with hyper

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Murtuza, Bohra, Patel Poonam, Dighe Kamayani, Ali Khan Rahat, and Ahmed Khan Aijaz. "Nephroprotective Role of Nigella Sativa Oil Against Gentamicin Induced Nephrotoxicity: An Experimental Study in Rats." International Journal of Toxicological and Pharmacological Research 12, no. 6 (2022): 91–101. https://doi.org/10.5281/zenodo.11658986.

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The objective of this study is to evaluate the nephroprotective activity and antioxidant potential of <em>Nigella sativa oil</em> against Gentamicin-induced nephrotoxicity. Healthy adult albino rats of either sex (100-200 g) was randomly divided into six groups of five animals each. Group I (normal control) were administered distilled water intra peritoneally for 8 days. Group II (LNSO). were administered low dose nigella sativa oil 1ml/kg orally for 10 days. Group III (HNSO) were administered High dose nigella sativa oil 2ml/kg orally for 10 days. Group IV (GNCG)Gentamicin negative

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Dinar, Nadhira M., Sheila Pratiwi, Rain Kihara, Nadia G. Paramita, Nazilla R. Fathurrahman, and Jutti Levita. "HEPATO-NEPHROPROTECTIVE ACTIVITY OF NIGELLA SATIVA OIL ON PARACETAMOL-INDUCED NEW ZEALAND RABBITS (ORYCTOLAGUS CUNICULUS)." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 10 (2017): 225. http://dx.doi.org/10.22159/ijpps.2017v9i11.21854.

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Objective: The objective of this work was to investigate the hepato-nephroprotective activity of Nigella sativa (Ranunculaceae) oil on paracetamol-induced New Zealand rabbits (Oryctolagus cuniculus).Methods: Hepato-nephroprotective activity of Nigella sativa oil was demonstrated on six groups of paracetamol-induced New Zealand rabbits (Oryctolagus cuniculus) aged 3-4 mo, three in each group (2 males, 1 female). Group I was normal control (water 1.0 ml/kg of body weight per oral), group II was negative control (water 1.0 ml/kg of body weight per oral), group III was positive control (silymarin

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Zaaba, Nur Elena, Suhail Al-Salam, Sumaya Beegam, Ozaz Elzaki, Javed Yasin та Abderrahim Nemmar. "Catalpol Attenuates Oxidative Stress and Inflammation via Mechanisms Involving Sirtuin-1 Activation and NF-κB Inhibition in Experimentally-Induced Chronic Kidney Disease". Nutrients 15, № 1 (2023): 237. http://dx.doi.org/10.3390/nu15010237.

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Chronic kidney disease (CKD) is a stealthy disease, and its development is linked to mechanisms including inflammation and oxidative stress. Catalpol (CAT), an iridoid glucoside from the root of Rehmannia glutinosa, is reported to manifest anti-inflammatory, antioxidant, antiapoptotic and antifibrotic properties. Hence, we studied the possible nephroprotective effects of CAT and its mechanisms in an adenine-induced (0.2% w/w in feed for 4 weeks) murine model of CKD by administering 5 mg/kg CAT to BALB/c mice for the duration of 4 weeks except during weekends. Upon sacrifice, the kidney, plasma

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Almundarij, Tariq I., Yousef M. Alharbi, Hassan A. Abdel-Rahman, and Hassan Barakat. "Antioxidant Activity, Phenolic Profile, and Nephroprotective Potential of Anastatica hierochuntica Ethanolic and Aqueous Extracts against CCl4-Induced Nephrotoxicity in Rats." Nutrients 13, no. 9 (2021): 2973. http://dx.doi.org/10.3390/nu13092973.

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Kaff-e-Maryam (Anastatica hierochuntica L.) is extensively used to treat a range of health problems, most notably to ease childbirth and alleviate reproductive system-related disorders. This study aimed to evaluate the effect of A. hierochuntica ethanolic (KEE), and aqueous (KAE) extracts on CCl4-induced oxidative stress and nephrotoxicity in rats using the biochemical markers for renal functions and antioxidant status as well as histopathological examinations of kidney tissue. A. hierochuntica contained 67.49 mg GAE g−1 of total phenolic compounds (TPC), 3.51 µg g−1 of total carotenoids (TC),

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Tan, Seyhmus, Bulent Kaya, Ercan Akburak, et al. "The Effect of Dapagliflozin, a Sodium–Glucose Co-Transporter 2 Inhibitor, on Vancomycin-Induced Nephrotoxicity in Rats." Biomedicines 13, no. 7 (2025): 1582. https://doi.org/10.3390/biomedicines13071582.

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Background/Objectives: Vancomycin-induced nephrotoxicity (VIN) remains a significant clinical challenge, with no effective nephroprotective agent currently established. This study aimed to evaluate the protective effects of the sodium–glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin (DAPA) against VIN in a Wistar albino rat model. Methods: Rats were randomly assigned to four groups: control, VA (vancomycin), DAPA (dapagliflozin), and VA+DAPA. Renal function was assessed by measuring serum urea and creatinine. Oxidative stress markers [malondialdehyde (MDA), total oxidant status (TOS), a

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Warsinah, Warsinah, Eka Prasasti Nur Rachmani, and Hartiwi Diastuti. "Preliminary Phytochemical Studies, GC-MS Analysis, and Anti-Nephrototic Activity of Ethanol Extract of Phoenix dactylifera L." Molekul 17, no. 3 (2022): 346. http://dx.doi.org/10.20884/1.jm.2022.17.3.5881.

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   Date palm seeds (Phoenix dactylifera L.) are known to contain phenolic compounds that have the potential as natural nephroprotective agents. Phenolics with solvents suitable for polarity and compounds identified by phytochemical screening, GC-MS analysis, and activity assays. This research went through 3 stages, screening with exploration and qualitative analysis of GCMS. The anti-nephrotoxic activity test used a pre-posttest controlled group design. In this study, rats have divided into six groups, namely Healthy control, negative control, and three treatment groups with

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Kanasaki, Keizo. "The role of renal dipeptidyl peptidase-4 in kidney disease: renal effects of dipeptidyl peptidase-4 inhibitors with a focus on linagliptin." Clinical Science 132, no. 4 (2018): 489–507. http://dx.doi.org/10.1042/cs20180031.

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Emerging evidence suggests that dipeptidyl peptidase-4 (DPP-4) inhibitors used to treat type 2 diabetes may have nephroprotective effects beyond the reduced renal risk conferred by glycemic control. DPP-4 is a ubiquitous protein with exopeptidase activity that exists in cell membrane-bound and soluble forms. The kidneys contain the highest levels of DPP-4, which is increased in diabetic nephropathy. DPP-4 inhibitors are a chemically heterogeneous class of drugs with important pharmacological differences. Of the globally marketed DPP-4 inhibitors, linagliptin is of particular interest for diabe

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Lopes, Matheus Tenório, Fernanda Carolina Ribeiro Dias, Mariana de França Oliveira da Silva, Caio Vinícius de Andrade Jesus, Katharina Medeiros Costa Gomes, and Valdemiro Amaro da Silva–Júnior. "Nephroprotective effect of Cannabis sativa oil nanoemulsion in rats exposed to valproic acid during the intrauterine period." Revista Eletrônica Acervo Saúde 25, no. 5 (2025): e20141. https://doi.org/10.25248/reas.e20141.2025.

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Objective: To evaluate the therapeutic effects of Cannabis sativa oil nanoemulsion (CBDON) on renal alterations induced by valproic acid (VPA) in rats. Methods: Pregnant female Wistar rats were exposed to VPA, and their offspring received treatment with CBD nanoemulsion at concentrations of 1% and 2%. After 60 days, evaluations were performed by means of body biometry, renal morphometry and oxidative stress analyses, with quantification of malondialdehyde (MDA) and antioxidant enzyme activity. Data were analyzed by descriptive and inferential statistics. Results: VPA caused a reduction in body

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Karaban, Łukasz, Tadeusz Kuźnieców, Monika Paszkowska, et al. "GLP-1 Receptor Agonists: Therapeutic Benefits in Renal Function, Cardiovascular Risk, and Physical Activity - A Systematic Review." Quality in Sport 41 (May 9, 2025): 60343. https://doi.org/10.12775/qs.2025.41.60343.

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Introduction: Type 2 diabetes is one of the greatest challenges of modern medicine. Its growing prevalence and numerous complications, especially cardiovascular ones, demand constant improvement of treatment strategies. Cardiovascular disease remains the leading cause of death in these patients, highlighting the importance of therapies that address both glycaemic control and cardiovascular risk. Aim of the study: This paper discusses the effects of GLP-1 receptor agonists (GLP-1 RA) and analyses recent data on their impact on cardiovascular risk, renal function, and interaction with physical a

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Sonfack, Christelle Stéphanie, Elvine Pami Nguelefack-Mbuyo, Jacquy Joyce Kojom, et al. "The Aqueous Extract from the Stem Bark of Garcinia lucida Vesque (Clusiaceae) Exhibits Cardioprotective and Nephroprotective Effects in Adenine-Induced Chronic Kidney Disease in Rats." Evidence-Based Complementary and Alternative Medicine 2021 (March 13, 2021): 1–11. http://dx.doi.org/10.1155/2021/5581041.

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Chronic kidney disease (CKD) is a serious health problem with high morbidity and mortality, mainly attributable to cardiovascular risk. Garcinia lucida is traditionally used in Cameroon for the management of cardiovascular diseases. The aim of this study was to evaluate the cardioprotective and nephroprotective effects of the aqueous extract from the stem bark of G. lucida (AEGL). The in vitro antioxidant effect of AEGL was assessed at concentrations ranging 1–300 μg/mL against DPPH, lipid peroxidation, and AAPH-induced hemolysis. The reducing power and phenolic and flavonoids contents were al

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Hegazy, Marwa G. A., Manal A. Emam, Hemmat I. Khattab, and Nesma M. Helal. "Biological activity of Echinops spinosus on inhibition of paracetamol-induced renal inflammation." Biochemistry and Cell Biology 97, no. 2 (2019): 176–86. http://dx.doi.org/10.1139/bcb-2018-0212.

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This study was designed to evaluate the possible mechanisms through which Echinops spinosus (ES) extract demonstrates nephroprotective effect on the paracetamol acetominophen (N-acetyl-p-aminophenol (APAP)) induced nephrotoxicity in rats. Twenty-four Swiss albino rats were divided into four groups (six rats each). The placebo group was orally administered sterile saline, the APAP group received APAP (200 mg·kg–1·day–1 i.p.) daily, the ES group was given ES extract orally (250 mg/kg), and the APAP + ES group received APAP as for the APAP group and administrated the ES extract as for the ES grou

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Sana, Sadik Attar* Shamal Kadam Amaan Inamdar Sakshi Jadhav Aanand Jadhav. "Herbal Approach to Chronic Kidney Disease: A Study on Multi-Herb Powder Formulation." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 5143–59. https://doi.org/10.5281/zenodo.15561174.

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The present study focuses on the formulation and evaluation of a polyherbal powder composed of Punarnava, Ashwagandha, Gokshura, Tulsi, and Amla, traditionally known for their beneficial effects on kidney health. The objective was to develop a natural formulation aimed at supporting the management of chronic kidney disease (CKD) through a safe and effective herbal approach. Each plant ingredient was selected based on its pharmacological properties such as anti-inflammatory, diuretic, antioxidant, and nephroprotective effects. Preliminary phytochemical analysis of the prepared polyherbal powder

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Lutsenko, R. V. "EFFECT OF 2-HYDROXY-N-NAPHTHALENE-1-YL-2-(2-OXO-1,2-DIHYDRO-INDOLE-3-YLYDENE)-ACETAMIDE ON KIDNEY FUNCTION IN EXPERIMENTAL RENAL FAILURE." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 23, no. 1 (2023): 94–97. http://dx.doi.org/10.31718/2077-1096.23.1.94.

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Heterocyclic compounds are the basis for a significant number of medicinal substances. Among them, there is indole and derivatives of 2-oxoindolin-3-glyoxylic acid. This group of compounds has been found out to have neurotropic effects as well as cardio- and hepatoprotective properties. This preceded the study of their nephroprotective activity in the experimental pathology. The aim of the work is to study the effect of 2-hydroxy-N-naphthalen-1-yl-2(2-oxo-1,2-dihydro-indol-3-ylidene)-acetamide on the excretory function of kidneys in the experimental acute renal failure. Materials and met

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Sherif, Al-Shaalan, and Sabry. "Ginkgo Biloba Extract Alleviates Methotrexate-Induced Renal Injury: New Impact on PI3K/Akt/mTOR Signaling and MALAT1 Expression." Biomolecules 9, no. 11 (2019): 691. http://dx.doi.org/10.3390/biom9110691.

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Renal injury induced by the chemotherapeutic agent methotrexate (MTX) is a serious adverse effect that has limited its use in the treatment of various clinical conditions. The antioxidant activity of Ginkgo biloba extract (GB) was reported to mitigate renal injury induced by MTX. Our research was conducted to examine the nephroprotective role of GB versus MTX-induced renal injury for the first time through its impact on the regulation of phosphatidylinositol 3-kinase/protein kinase B/ mammalian target of rapamycin (PI3K/Akt/mTOR) signaling together with the renal level of TGF-β mRNA and long n

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Strutynska, O. B., and A. V. Melnyk. "Morphological changes in the kidney tissue of rats with experimental diabetes mellitus and during correction with metformin and modulators of hydrogen sulfide metabolism." Reports of Vinnytsia National Medical University 27, no. 1 (2023): 10–16. http://dx.doi.org/10.31393/reports-vnmedical-2023-27(1)-02.

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Annotation. Metformin is widely used for pharmacocorrection of diabetic nephropathy in type 2 diabetes mellitus. However, the mechanisms of the protective effect of metformin on the kidneys remain unclear, in particular, the contribution of the hydrogen sulfide system to metformin’s nephroprotective effect is unknown. Therefore, the aim of our study was to assess the role of metformin and its combination with modulators of hydrogen sulfide metabolism in the correction of histological changes in the kidneys of streptozotocin-induced diabetic rats. The studies were performed on 30 white non-line

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SOMSAK, Voravuth, and Somrudee NAKINCHAT. "Antimalarial, Anti-hemolytic, Hepatoprotective, and Nephroprotective Activities of Gynostemma pentaphyllum Leaf Extract in Plasmodium berghei Infection in Mice." Walailak Journal of Science and Technology (WJST) 15, no. 2 (2017): 143–50. http://dx.doi.org/10.48048/wjst.2018.4290.

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Malaria is still a major problem around the world, especially in tropical and sub-tropical zones. Malaria-associated hemolysis and liver and renal injuries have been reported to be causes of death in malaria cases. In this respect, finding plant extracts which have a protective effect against these pathologies induced by malaria are urgently needed. The present study aimed to evaluate the antimalarial, anti-hemolytic, hepatoprotective, and nephroprotective properties of Gynostemma pentaphyllum leaf extract (GPE) in Plasmodium berghei infected mice. ICR mice were infected intraperitoneally with

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