Relevant bibliographies by topics / Nephrosphere

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  1. Journal articles
  2. Dissertations / Theses

Academic literature on the topic 'Nephrosphere'

Author: Grafiati
Published: 9 March 2023
Last updated: 31 July 2025

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Journal articles on the topic "Nephrosphere"

1

Bombelli, Silvia, Chiara Meregalli, Chiara Grasselli, et al. "PKHhigh/CD133+/CD24− Renal Stem-Like Cells Isolated from Human Nephrospheres Exhibit In Vitro Multipotency." Cells 9, no. 8 (2020): 1805. http://dx.doi.org/10.3390/cells9081805.

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The mechanism upon which human kidneys undergo regeneration is debated, though different lineage-tracing mouse models have tried to explain the cellular types and the mechanisms involved. Different sources of human renal progenitors have been proposed, but it is difficult to argue whether these populations have the same capacities that have been described in mice. Using the nephrosphere (NS) model, we isolated the quiescent population of adult human renal stem-like PKHhigh/CD133+/CD24− cells (RSC). The aim of this study was to deepen the RSC in vitro multipotency capacity. RSC, not expressing
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Bombelli, Silvia, Chiara Meregalli, Carla Scalia, et al. "Nephrosphere-Derived Cells Are Induced to Multilineage Differentiation when Cultured on Human Decellularized Kidney Scaffolds." American Journal of Pathology 188, no. 1 (2018): 184–95. http://dx.doi.org/10.1016/j.ajpath.2017.09.012.

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3

Bombelli, Silvia, Maria Anna Zipeto, Barbara Torsello, et al. "PKHhigh cells within clonal human nephrospheres provide a purified adult renal stem cell population." Stem Cell Research 11, no. 3 (2013): 1163–77. http://dx.doi.org/10.1016/j.scr.2013.08.004.

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4

Singhal, Sonalika, Scott H. Garrett, Seema Somji, et al. "Arsenite Exposure to Human RPCs (HRTPT) Produces a Reversible Epithelial Mesenchymal Transition (EMT): In-Vitro and In-Silico Study." International Journal of Molecular Sciences 24, no. 6 (2023): 5092. http://dx.doi.org/10.3390/ijms24065092.

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The human kidney is known to possess renal progenitor cells (RPCs) that can assist in the repair of acute tubular injury. The RPCs are sparsely located as single cells throughout the kidney. We recently generated an immortalized human renal progenitor cell line (HRTPT) that co-expresses PROM1/CD24 and expresses features expected on RPCs. This included the ability to form nephrospheres, differentiate on the surface of Matrigel, and undergo adipogenic, neurogenic, and osteogenic differentiation. These cells were used in the present study to determine how the cells would respond when exposed to n
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5

Bombelli, Silvia, Chiara Grasselli, Paolo Mazzola, et al. "Impairment of Renal and Hematopoietic Stem/Progenitor Cell Compartments in Frailty Syndrome: Link with Oxidative Stress, Plasma Cytokine Profiles and Nuclear DNA Damage." Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, July 27, 2024. http://dx.doi.org/10.1093/gerona/glae188.

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Abstract Frailty is an age-related syndrome that drives multiple physiological system impairments in some older adults, and its pathophysiological mechanisms remain unclear. We evaluated whether frailty-related biological processes could impair stem cell compartments, specifically the renal stem compartment, given that kidney dysfunctions are frequent in frailty. A well-characterized in vitro nephrosphere model of human adult renal stem/progenitor cells has been instrumental to and was appropriate for verifying this hypothesis in our current research. Evaluating the effects of plasma from olde
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Knafl, Daniela, Wolfgang Winnicki, Peter Mazal, and Ludwig Wagner. "Urinary nephrospheres indicate recovery from acute kidney injury in renal allograft recipients – a pilot study." BMC Nephrology 20, no. 1 (2019). http://dx.doi.org/10.1186/s12882-019-1454-3.

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Dissertations / Theses on the topic "Nephrosphere"

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BOMBELLI, SILVIA. "Isolamento e caratterizzazione di cellule staminali adulte da rene normale e carcinoma renale." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2010. http://hdl.handle.net/10281/7970.

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In recent years, numerous cancers have been described as having a "cancer stem cell" (CSC) population also known as "cancer initiating cells". CSCs refer to a subset of tumour cells that has the ability to self-renew and generate the diverse cells that comprise the tumor. Their name derives from their "stem-like" properties and ability to continually sustain tumorigenesis. CSCs have the same properties that define a normal tissue adult stem cell, even if they are aberrant: self-renewal and differentiation. Renal cell carcinoma (RCC) accounts for about 3% of adult cancers and is among the 10 m
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GRASSELLI, CHIARA. "Biological conditions related to frailty and their effects on adult renal stem cells cultured as nephrospheres." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2022. http://hdl.handle.net/10281/360937.

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La fragilità è una sindrome geriatrica definita da un progressivo declino età-correlato di diverse facoltà fisiologiche, che si traduce in una ridotta funzionalità d’organo e in un’aumentata vulnerabilità in condizioni di stress. Fried e coll. propongono una definizione operativa delle fragilità. La letteratura riporta un’alta prevalenza di fragilità in individui affetti da insufficienza renale cronica. Tra questi soggetti, il rischio di sviluppare fragilità è aumentato di due/tre volte rispetto ai soggetti sani. Ad oggi, la definizione e la valutazione della fragilità in questi pazienti è anc
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3

MEREGALLI, CHIARA. "STUDY OF MULTIPOTENT RENAL PKHHIGH STEM-LIKE CELLS, ISOLATED FROM HUMAN NEPHROSPHERES: REGENERATIVE ABILITIES AND TRANSCRIPTOMIC PROFILE." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2018. http://hdl.handle.net/10281/199041.

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Il meccanismo alla base della riparazione di un danno a cellule renali è ancora oggi oggetto di dibattito e potrebbe coinvolgere sia cellule terminalmente differenziate che l'esistenza di cellule staminali multipotenti quiescenti. Sfruttando il saggio di formazione di sfere e la tecnica del FACS sorting, il nostro gruppo ha isolato una popolazione di cellule marcate col clorante PKH26 che avessero caratteristiche di cellule staminali renali adulte (PKHhigh). In precedenza abbiamo valutato la capacità di queste cellule di differenziare in vitro in lineage epiteliale, podocitico ed endoteliale.
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