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Ananya, Debbarma, and C. Mehta Neeta. "A STUDY TO COMPARE NERVE CONDUCTION VELOCITIES IN DOMINANT AND NONDOMINANT HANDS OF ADULTS." International Journal of Basic and Applied Physiology 7, no. 1 (2018): 75–80. https://doi.org/10.5281/zenodo.4481499.
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Background and Objectives: Nerve Conduction Velocity(NCV) study is a part of Clinical Neurophysiology. Nerve Conduction Study is a test commonly used to evaluate the functions of the motor and sensory nerves of the body. It has emerged as a major tool for diagnosis of nerve function disorders. Handedness also known as chirality is a human nature due to unequal distribution of fine motor skills between the left and right hands. The aim was to compare the NCV between left handed and right handed subjects using median, ulnar and radial nerve and find out whether there is any difference in NCV(motor or sensory) with handedness. Method: The Nerve conduction study was performed on a RMS EMG EPMK II Electrophysiology machine. Motor and sensory NCV of the median, ulnar and radial nerves in the left and right upper limbs was compared in 50 right and 50 left handed subjects of both gender between 18 to 40 years. Result: Data analysis was performed through standard statistical methods. Median motor NCV was higher in right handed subjects. Sensory NCV were higher in left handed subjects Conclusion: Different range of values of motor and sensory nerve conduction velocity for left and right handed persons.
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Dipti, Thakker, J. Shah N, and Trivedi R.S. "TO STUDY THE EFFECT OF BMI ON NERVE CONDUCTION VELOCITY." TO STUDY THE EFFECT OF BMI ON NERVE CONDUCTION VELOCITY 8, no. 1 (2019): 73–77. https://doi.org/10.5281/zenodo.4485084.
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<strong>Background & objectives:</strong> Age, height and weight are the physiological factors which influence the nerve conduction velocity. Obesity is a growing public health concern and it is associated with various disorders. Body mass index (BMI) is an important parameter to measure obesity. Present study is an effort to determine relationship between nerve conduction velocity of median, ulnar and radial nerves and obesity in healthy individuals. <strong>Methods:</strong> In the present study the effect of Body Mass Index (BMI) on Median, Ulnar and Radial motor and sensory nerve conduction velocities of healthy individuals is compared. Standardized protocol was followed while execution nerve conduction study in all the subjects. <strong>Results</strong>: Comparison of NCV findings with BMI shows the values of median motor, ulnar motor, median sensory, ulnar sensory and radial sensory nerves of left hand and median motor, median sensory, ulnar sensory and radial sensory nerve conduction velocities of right hand are significantly reduced (p value < 0.05) in obese individual as compared to normal weight individuals. <strong>Interpretation & conclusion</strong>: The findings of our study suggest that there is significant correlation with NCV and BMI. People with higher BMI have reduction in NCV of various motor and sensory nerves. This could be due to thicker subcutaneous tissue in persons with higher BMI.
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Kunipuri, Sarala, Pavani R., Devasena Indla., and Lakshmi S. "Nerve Conduction Studyin Type 2 Diabetic Patients." International Journal of Pharmaceutical and Clinical Research 15, no. 12 (2023): 895–98. https://doi.org/10.5281/zenodo.11194224.
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Nerve conduction velocity (NCV) test measures the speed of conduction of an electrical impulse through a nerve. The NCV test can establish nerve damage and devastation. Nerve conduction studies (NCS) are regularly conducted to identify the neuropathy. This study will help to observe the difference in nerve conduction velocity between non diabetic and type II diabetic individuals. The present study was undertaken for a period of subjects, both males and females aged between 40-50 years, informed written consent was taken from the subjects. The study group consisted of 25 diabetic patients, with history of diabetes for 1-10 years and controls (Non Diabetics) were 30 age and sex matched healthy individuals. Comparison of sensory nerve parameters in Control Group (non diabetics) and diabetics shows there is highly significant slowing of sensory nerves median & ulnar (p<0.001) and decrease in amplitude of Median nerve(p<0.05) in diabetics compared to controls. The study proved neuronal involvement in the diabetes mellitus which is accelerated by poor glycaemic control. Therefore nerve conduction studies should be carried out for the early detection and management of neuropathy in the diabetic patients.
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Priyanka, Abhishek Kumar, and Prasad Anjali Krishna. "Survey of body mass index (BMI) on median motor nerve conduction velocity (NCV) in normal population of Malwa region." Indian Journal of Clinical Anatomy and Physiology 10, no. 2 (2023): 104–7. http://dx.doi.org/10.18231/j.ijcap.2023.022.
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: Nerve conduction studies reveal technique to work on peripheral nerve being capable in revealing nerve-related issue. It aids in distinguishing from a nerve injury to situation where muscles are affected due to a nerve lesion. While, in that respect much dissimilarity persist in use of Nerve Conduction Velocity (NCV) in different nerves with regard to place, sex, mass & other ethnographical facts i.e. Span of life. This has been viewed in performing nerve conduction studies while ethnograpical part differs for different geological region.: The purpose of present work is to do the Nerve Conduction Variables (NCV) studies in rt. median nerve in usual well young of Malwa region and to study the outcome of B.M.I on it. : A total 110 healthy participants from the periods of 20 and 50 years, with none nerve lesion, being examined at IMCHRC, Indore. All trial were completed on JAVA RMSAleron-201 series. Scrutiny on SPSS 10.0 series. : The mean of NCV firstly rises among periods of 20-30 yrs, 31-40 yrs & 40-50years, preceded by a fall in the mean NCV of elbow–wrist segment which significantly fall while the mean of B.M.I rises with increasing length of life. It is to be noted that NCV was inversely related to an increase in B.M.I in the volunteer the mean NCV of Set 1 &#62; Set2, Set3, Set 4 with P &#60; 0.05 that toply relevant.Usual parameter for conduction in peripheral nerves to be used in the test of peripheral nerve lesion. B.M.I has a definitive effect on NCV. So, this factor has been put into concern during interpretation of results during nerve conduction studies. Therefore, it should also be used for research purposes & in prognosis approach.
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Maurya, Lavkush, Shraddha Singh, and S. C. Chaudhary. "Impact of Type 2 Diabetes Mellitus Duration on Sural Nerve Conduction Velocity: A Cross-Sectional Study." International Journal of Health Sciences and Research 14, no. 9 (2024): 225–31. http://dx.doi.org/10.52403/ijhsr.20240929.
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Objective: To evaluate the nerve conduction velocity (NCV) of the sural nerve in patients with Type 2 Diabetes Mellitus (T2DM) and compare it with healthy controls, focusing on the impact of the disease's duration on NCV. Methods: This cross-sectional study included 90 T2DM patients divided into two groups based on disease duration (<5 years and >10 years) and 45 healthy controls. Sural nerve NCV was measured using an Octopus NCV/EMG/EP machine. Statistical analysis was performed using SPSS. Results: The NCV of the sural nerve was significantly lower in T2DM patients compared to controls (p<0.001). NCV decreased significantly with increasing duration of diabetes, showing a reduction of approximately 1.80 m/s per year for the left sural nerve and 1.97 m/s per year for the right sural nerve. Conclusions: Prolonged T2DM is associated with a significant reduction in sural nerve conduction velocity, indicating progressive nerve damage. Early diagnosis and management are crucial to prevent severe neuropathic complications. Key words: Nerve Conduction Velocity, Sural Nerve, Type 2 Diabetes Mellitus, Diabetic Neuropathy
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Prashant, Praveen, Sat Pal, Abhishek Bansal, and Sanjay Fotedar. "Nerve conduction velocity studies in diabetic peripheral neuropathy involving sural nerve—A meta-analysis." Journal of Family Medicine and Primary Care 13, no. 10 (2024): 4469–75. http://dx.doi.org/10.4103/jfmpc.jfmpc_304_24.
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ABSTRACT Introduction: Diabetes mellitus (DM) poses a significant health burden globally, impacting millions due to its metabolic disruptions. Among its complications, diabetic peripheral neuropathy (DPN) is a prevalent concern, affecting sensory and motor nerves. While various diagnostic methods exist, discrepancies persist in prevalence estimates of DPN among diabetic populations. Objective: This meta-analysis aimed to assess the prevalence of DPN in individuals with DM, focusing on sural nerve conduction velocity (NCV) measurements. Additionally, the study explored how different evaluation techniques influenced prevalence estimates. Methods: A systematic literature search was conducted following PRISMA guidelines across multiple databases. Studies reporting sural nerve NCV measurements in diabetic patients were included. Data extraction, quality assessment, and statistical analyses were performed to synthesize findings. Results: Twenty-six studies met the inclusion criteria, providing insights into sural nerve NCV among diabetic individuals. Pooled analysis revealed a mean sural nerve NCV of 42.12 m/s (95% CI: 39.87-44.36), indicative of reduced conduction velocity in diabetic populations. Furthermore, sural nerve amplitude was significantly lower in diabetic individuals, with a pooled mean of 4.68 μV (95% CI: 3.11-6.25). Conclusion: Individuals with type 2 DM exhibit impaired sural nerve function, as evidenced by reduced NCV and amplitude measurements. Timely NCV assessment, alongside glycemic monitoring, is crucial for identifying and managing DPN to prevent further complications. Interventions addressing glycemic control, dietary regulation, and lifestyle modifications are recommended to mitigate the progression of neuropathy in diabetic populations.
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Reed, T. Edward, and Arthur R. Jensen. "Arm nerve conduction velocity (NCV), brain NCV, reaction time, and intelligence." Intelligence 15, no. 1 (1991): 33–47. http://dx.doi.org/10.1016/0160-2896(91)90021-5.
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Bhavna, Gupta, Batham Chhaya, Waghmare Shilpa, and Verma Pratibha. "Nerve Conduction Velocity and Effect of Different Phases of Menstrual Cycle on it." International Journal of Pharmaceutical and Clinical Research 15, no. 6 (2023): 1779–84. https://doi.org/10.5281/zenodo.12516558.
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<strong>Objective: </strong>The study was done to find out the effect of different phases of menstrual cycle on the Nerve conduction velocity in females. <strong>Methods: </strong>50 normal menstruating women with age between 18 to 24 years, with regular menstrual cycle were randomly selected from the nearest nursing college hostel and were included in the study. Evoked electromyogram (EMG) was used to measure the nerve conduction velocity of median nerve in all the three phases of menstrual cycle i.e. proliferative, secretory and menstrual phase. Their mean values were calculated and compared in all the three phases. <strong>Results:</strong> When the mean of nerve conduction velocities in different phases of menstrual cycle were compared, a decrease in the NCV was observed in the secretory phase as compared to the menstrual and proliferative phase but the p value was not significant. <strong>Conclusion:</strong> Nerve conduction velocity of the peripheral nerves does not vary significantly during the different phases of the menstrual cycle. However these parameters should be kept in mind while conducting studies on nerve conduction velocities.
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Nobue, Ayaka, and Masaki Ishikawa. "Sex-Specific Differences in Peripheral Nerve Properties: A Comparative Analysis of Conduction Velocity and Cross-Sectional Area in Upper and Lower Limbs." Diagnostics 14, no. 23 (2024): 2711. https://doi.org/10.3390/diagnostics14232711.
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Background/Objectives: Peripheral nerve conduction velocity (NCV) and nerve cross-sectional area (nCSA) are crucial parameters in neurophysiological assessments, yet their sex-specific differences are not fully understood. This study investigated sex-based variations in NCV and nCSA between upper and lower limbs. Methods: Twenty participants (ten males and ten females) were recruited for this study. The NCV and nCSA of the ulnar and tibial nerves were measured in both the upper and lower limbs. NCV was measured using supramaximal electric stimulation, and nCSA was assessed using peripheral nerve ultrasonography at three regions for each nerve. Supramaximal electric stimulations were applied superficially to the ulnar and tibial nerves at each measurement point. Action potentials were recorded from the abductor digiti minimi and soleus muscles for the ulnar and tibial nerves, respectively. Results: The ulnar nCSA of the upper limbs was significantly greater in males than in females (p < 0.05). However, ulnar NCV was significantly higher in females than in males (p < 0.05). In the lower limbs, no sex differences were observed in tibial NCV or nCSA. Conclusions: These findings reveal sex-specific differences in upper limb peripheral nerve characteristics that may have important implications for clinical assessments and treatment strategies. The contrasting patterns between upper and lower limbs suggest that both developmental and functional factors influence peripheral nerve properties.
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Almuklass, Awad M., Abdulmajeed Mansour Alassaf, Rakan F. Alanazi, Turki Rashed Alnafisah, Thamir Ali Alrehaily, and Yaser Al Malik. "Nerve conduction, latency, and its association with hand function in young men." PLOS ONE 19, no. 9 (2024): e0310813. http://dx.doi.org/10.1371/journal.pone.0310813.
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Introduction The median and ulnar nerves have been suggested to play a significant role in hand function; however, there are insufficient data to determine the strength of this association. This study aimed to investigate the correlation between hand function as measured with the Grooved pegboard test (GPT) and conduction velocity and latency of the median and ulnar nerves. Methods We collected convenience samples in the College of Medicine, KSAU-HS. We used GPT to characterize hand function and performed measured nerve conduction velocity (NCV) and latency of the ulnar and median nerves of both hands. We used the Edinburgh handedness inventory (EHI) to determine hand dominance. Results We recruited 28 healthy medical students aged 20–29 years (mean: 21.46 ± 1.62 years). Most were right-handed (n = 25, 89.3%), with a mean EHI score of 302 ± 210. The mean GPT time was significantly faster in the dominant (65.5 ± 6.4 s) than in the non-dominant (75.0 ± 9.6 s) hand. The NCV for the ulnar nerve of the dominant hand was significantly correlated with GPT (r = -0.52, p = 0.005) while median nerve was not correlated (0.24, p = 0.21). Regression analysis and collinearity test showed that the ulnar NCV explained 20% of the variance in GPT of the dominant hand (R2 = 0.203, p = 0.016). Conclusion The ulnar nerve conduction velocity, explained 20% of the variance in GPT times of the young men. Performance on this biomarker of neurological health seems to be more influenced by other factors in healthy young individuals.
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Anand, Ravi, Sneha Bhushan, and Bharat Bhushan. "Comparative Analysis of Diabetic Neuropathy Examination Scores and Nerve Conduction Velocity in Patients with Diabetic Neuropathy." International Journal of Medical and Biomedical Studies 8, no. 3 (2024): 143–50. http://dx.doi.org/10.32553/ijmbs.v8i3.2829.
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Background: Diabetic neuropathy is a prevalent consequence of diabetes, resulting in substantial morbidity. Precise evaluation is essential for prompt intervention and control. The study assessed the correlation and effectiveness of the Diabetic Neuropathy Examination (DNE) scores and Nerve Conduction Velocity (NCV) as diagnostic tools in individuals with diabetic neuropathy. Methods: An observational research was done, comprising 200 diabetic patients who were diagnosed with diabetic sensory-motor polyneuropathy. Participants completed Dynamic Neuromuscular Examination (DNE) grading and Nerve Conduction Velocity (NCV) testing. The data were analysed using SPSS version 20.0. Results: The study found a considerable negative correlation (r = -0.68, p < 0.001) between DNE scores and NCV results. Higher DNE scores were associated with lower NCV values. Specifically, 20% of participants had mild neuropathy, 40% had moderate neuropathy, and 40% had severe neuropathy according to DNE scores. NCV testing revealed that 65% of participants had abnormal nerve conduction, with 25% showing mild reduction, 25% moderate reduction, and 15% severe reduction. Multivariate regression confirmed that DNE scores are significant predictors of NCV outcomes (Beta = -0.52, p < 0.001), even after adjusting for confounding variables such as gender, age, diabetes duration, and HbA1C levels. Conclusion: DNE scoring is a reliable tool for assessing neuropathy severity in diabetic patients, correlating well with NCV results. Integrating DNE scoring in routine clinical practice can enhance the early detection and management of diabetic neuropathy. Recommendations: Routine use of DNE scoring along with NCV testing is recommended for comprehensive evaluation of diabetic neuropathy. Further research should explore additional diagnostic tools to improve early detection and intervention. Keywords: Diabetic Neuropathy, Diabetic Neuropathy Examination Score, Nerve Conduction Velocity Testing, Diabetic Polyneuropathy, Neuropathy Assessment..
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Prathusha, Nerella, Ashwini Namanandi, and Vempati Alekhya. "Study of Nerve Conduction Velocity in Type-2 Diabetic Patients with Neuropathy in Tamil Nadu Population." International Journal of Pharmaceutical and Clinical Research 15, no. 8 (2023): 851–55. https://doi.org/10.5281/zenodo.11506941.
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<strong>Background:</strong> Neuropathy in Type -2 diabetic patients mainly causes sensory symptoms and signs of nerve dysfunction which are more subjective. Hence, a neuro-physiological study has to be done to study the pathophysiology, severity and prognosis of neuropathy in these patients. <strong>Method:</strong> 95 patients diagnosed with Type-2 DM of duration more than 1 year to more than five years were studied. Electro-physiological tests were done for measuring NCV and SNAP of median, peroneal and sural nerves. These tests were carried out using the EMG/NCV/EP ALERON 202 channel machine. <strong>Results:</strong> In each nerve, NCV and SNAP values were higher in newly diagnosed patients and diabetic patients of 1 year duration and quite less in those diagnosed with more than 5 years duration. <strong>Conclusion:</strong> The present parameters of NCV and SNAP will help the physician, endocrinologist, and neurophysician predict the prognosis of nerve dysfunction in Type -2 Diabetes patients and treat them efficiently to avoid mortality and morbidity among those patients.
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Rattan, Yamini, Shikha Jhamb, and Avnish Kumar. "Nerve conduction study: A reliable approach to assess the effect of electromagnetic waves on median nerve." National Journal of Physiology, Pharmacy and Pharmacology 14, no. 5 (2024): 1. http://dx.doi.org/10.5455/njppp.2023.13.08392202329092023.
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Background: Mobile phones and other touchscreen devices emit dangerous electromagnetic radiation that negatively affect nerve function, with the median nerve being the most vulnerable because it is mostly utilized for mobile phone typing. Nerve conduction studies (NCSs) can be used to successfully diagnose this change in nerve function NCS. Aims and Objectives: The goal of the study was to ascertain the impact of electromagnetic waves from mobile phones on the median nerve’s nerve conduction velocity (NCV). Materials and Methods: 150 young, healthy medical students participated in a cross-sectional (observational) study, and they were split into two groups based on how long they used their mobile phones: Group 1 (<30 min usage) and Group 2 (>30 min usage). The median nerves in both upper limbs were measured for their NCV, and the results were statistically analyzed using the student “t” test for equal variance for various parameters. Results: The research found that Group 1 participants, who use cell phones more frequently and for longer periods of time, had significantly reduced (impaired) sensory NCV of the median nerve. Conclusion: Smartphones and other touchscreen gadgets, depending on time of exposure and usage frequency, can negatively impact nerve function, resulting in a decrease in the median nerve’s conduction velocity, and this can be very efficiently diagnosed with the use of NCSs.
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Anita, Verma, Mahajan Swati, and Khadayate Prashant. "Sensory Nerve Conduction Studies In Non-Insulin Dependent Diabetes Mellitus (NIDDM) Patients Without Symptoms Of Peripheral Neuropathy And Healthy Volunteers: A Comparative Study." International Journal of Basic and Applied Physiology 2, no. 1 (2013): 158–62. https://doi.org/10.5281/zenodo.4490507.
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NIDDM is one of the chronic diseases all over the world. Prevalence and incidence is highest in Asian countries. Diabetic Neuropathy is one of the commonest long term complications of NIDDM Electro diagnostic tests can be used to detect diabetic neuropathy at an early stage (before development of the signs or symptoms of neuropathy). Nerve conduction study (NCV) is considered to be the most sensitive reliable noninvasive and objective means of investigations of diabetic polyneuropathy. Diabetic neuropathy is curable, and hence if detected, the proper treatment can be instituted in early stages, which again, can give rise to good outcome. As the peripheral nerve has the ability to regenerate, line of treatment can be planned. Aim & Objective: To use recent advancement of technology as a means of assessing the functional status of sensory fiber with particular emphasis upon the correlation between non-insulin dependent diabetes mellitus (NIDDM) and the degree of Neuropathy. Method: 50 diabetic & 50 non diabetic controls of comparable age & BMI were selected. Sensory nerve conduction velocity was measured by orthodromic stimulation with the help of the EMG-NCV recording machine, Neuroperfect plus of Medicaid systems. Result: Out of 50 randomly selected Diabetics, 20 cases showed attenuation of amplitude and slowing of conduction velocity. It suggests 40 percent of total cases are having Neuropathy. Conclusion: Nerve conduction studies can diagnose Diabetic Neuropathy at a very early stage even before symptoms & signs set in. Hence, NCS being simple, harmless, non-invasive and objective technique along with easy interpretation of results can be used routinely to obtain considerable information and evaluate the status of nerves in patients with NIDDM.
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Ito, Azusa, Hiroshi Kunikata, Masayuki Yasuda, et al. "The Relationship between Peripheral Nerve Conduction Velocity and Ophthalmological Findings in Type 2 Diabetes Patients with Early Diabetic Retinopathy." Journal of Ophthalmology 2018 (2018): 1–7. http://dx.doi.org/10.1155/2018/2439691.
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Purpose. Nerve conduction velocity (NCV) is an indicator of neuronal damage in the distal segment of the peripheral nerves. Here, we determined the association between NCV and other systemic and ocular clinical findings, in type 2 diabetes patients with early diabetic retinopathy (DR). Methods. This study included 42 eyes of 42 type 2 diabetes patients (median age: 54 years) with no DR or with mild nonproliferative DR. Standard statistical techniques were used to determine associations between clinical findings. Results. Sural sensory conduction velocity (SCV) and tibial motor conduction velocity (MCV) were significantly lower in mild nonproliferative DR patients than patients with no DR (P=0.008 and P=0.01, resp.). Furthermore, logistic regression analyses revealed that sural SCV and tibial MCV were independent factors contributing to the presence of mild nonproliferative DR (OR 0.83, P=0.012 and OR 0.69 P=0.02, resp.). Tibial MCV was correlated with choroidal thickness (CT) (P=0.01), and a multiple regression analysis revealed that age, tibial MCV, and carotid intima-media thickness were independent associating factors with CT (P=0.035, P=0.015, and P=0.008, resp.). Conclusions. Our findings suggest that reduced NCV may be closely associated with early DR in type 2 diabetes patients. Thus, reduced nerve conduction is a potential early biomarker of DR.
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Orzheshkovskyi, V. V. "СOMPARATIVE CHARACTERISTIC OF NERVE CONDUCTION STUDIES AT CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY AND HEREDITARY MOTORSENSORY NEUROPATHY TYPE 1". National Journal of Neurology 1, № 18 (2018): 22–28. http://dx.doi.org/10.61788/njn.v1i18.03.
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Results of the carried-out comparative analysis of nerve conduction studies indicators of 78 patients with demyelinating polyneuropathy (40 patients with the chronic inflammatory demyelinating polyneuropathy (CIDP) and 38 with hereditary motor and sensory neuropathy (NMSN) of type 1). It is revealed that nerve conduction studies characteristics of CIDP and NMSN of type 1 have similar lines in connection with the similar mechanism of a pathogeny - demyelination. The distinctive characteristic is uniformity of distribution of demyelinationat NMSN of type 1 in the form of uniform reduction of motor nerve conduction velocity (NCV) and compound motor action potential in the majority of the lesion peripheral nerves of extremities and high correlation dependence of indicators of NCV on tibialis on a longitudinal axis and with NCV on n.medialis and amplitude indicators at stimulation of n.medialis at patients with NMSN of type 1; patients with CIDP have a high variability and a symmetry of defeat with existence of conduction blocks and high correlation communication of amplitude indicators at stimulation of n.tibialis in distal and proximal departments.
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Maalmi, Haifa, Kristiaan Wouters, Hans H. C. M. Savelberg, et al. "Associations of cells from both innate and adaptive immunity with lower nerve conduction velocity: the Maastricht Study." BMJ Open Diabetes Research & Care 9, no. 1 (2021): e001698. http://dx.doi.org/10.1136/bmjdrc-2020-001698.
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IntroductionDistal sensorimotor polyneuropathy (DSPN) is common in people with diabetes but is also found in pre-diabetes. Peripheral nerve myelin damage, which can be assessed by reduced nerve conduction velocity (NCV), is an essential feature of DSPN. Emerging evidence indicates that the development of DSPN may involve the activation of the immune system. However, available studies have mainly investigated circulating immune mediators, whereas the role of immune cells remains unclear. Therefore, we aimed to test whether leukocyte subsets are associated with NCV.Research design and methodsThis cross-sectional study analyzed data from 850 individuals (of whom 252 and 118 had type 2 diabetes and pre-diabetes, respectively) of the Maastricht Study. NCV was measured in the peroneal and tibial motor nerves and the sural sensory nerve and summed to calculate a standardized NCV sum score. Associations between percentages of leukocyte subsets and NCV sum scores were estimated using linear regression models adjusted for demographic, lifestyle, metabolic and clinical covariates.ResultsAfter adjustment for covariates, higher percentages of basophils and CD4+ T cells were associated with lower NCV (p=0.014 and p=0.005, respectively). The percentage of CD8+ T cells was positively associated with NCV (p=0.022). These associations were not modified by glucose metabolism status (all pinteraction >0.05). No associations were found for monocytes, eosinophils, neutrophils, lymphocytes, total T cells, Treg cells and B cells.ConclusionsThe associations of basophils, CD4+ and CD8+ T cells with NCV suggest that cell types from both innate and adaptive immunity may be implicated in the development of DSPN.
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Bhowmik, Nirmalendu Bikash, Md Rashedul Islam, Rumana Habib, Aminur Rahman, Zahid Hassan, and Md Amirul Haque. "Abnormal Nerve Conduction Parameters in Young Diabetic Patients at Diagnosis." BIRDEM Medical Journal 5, no. 1 (2016): 14–19. http://dx.doi.org/10.3329/birdem.v5i1.28368.
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Background and Objectives: Diabetes in the young patients, less than 30 years of age, usually has sudden onset and severe hyperglycemia who are resistant to ketosis. Taking the advantage of this uniqueness of this group of patients the present study was aimed to evaluate their peripheral nerve functional status, explore its relationship with glycemic status and find out utility of nerve conduction study for detection of neuropathy at diagnosis to introduce timely intervention in the necessary cases.Materials and Methods: A total number of 32 newly diagnosed untreated diabetic patients, age 30 years or less, consecutively attending the BIRDEM Out-patient department were recruited. Age-matched healthy subjects (n=30) with no family history of diabetes served as controls. Motor and sensory conduction velocities (NCV), distal latencies (DL), compound muscle and sensory nerve action potentials (CAMP, SNAP) of ulnar, peroneal and sural nerves were studied following standard protocol. Glucose was determined by glucose-oxidase, Fructosamine by enzymatic colorimetric method.Results: Ulnar motor NCV (m/sec, mean±SD) was significantly slower in diabetic group compared to the controls [58.29±6.88 vs 66.56±6.13; p<0.001]. CAMP [(?v, median] of ulnar nerve was significantly lower in diabetic patients [4.5 vs 5.8; p<0.05]. Motor nerve conduction velocity of peroneal nerve was significantly slower (p<0.0001) in diabetic patients. Peroneal nerve CMAP [?v, median] amplitude showed similar trends [5.5 vs 8.7 p<0.001]. Sural sensory NCV was significantly slower [35.22±14.04 vs 42.38±8.52; p<0.05] in diabetic patients. Peroneal nerve conduction velocity showed significant negative correlation with fasting glucose (r= -0.456, p<0.001). Peroneal motor distal latency showed positive correlation with serum fructosamine value [r=0.439, p<0.05]. Peroneal and ulnar NCV was negatively correlated [p<0.001 and p<0.05 respectively] with fructosamine. Sural sensory nerve action potential was also negatively correlated [r=-0.400 p<0.05]. S. Fructosamine was negatively correlated with sensory ulnar nerve action potential.Conclusion: The result suggest that in the newly diagnosed untreated young diabetics of Bangladesh, abnormalities of nerve conduction parameters are detected early by doing nerve conduction study; motor nerve conduction parameters are affected more than sensory ones. Abnormal nerve conduction parameters seem to be related to degree of hyperglycaemia in early neuropathic patients.Birdem Med J 2015; 5(1): 14-19
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Luo, T. David, Amy P. Trammell, Luke P. Hedrick, Ethan R. Wiesler, Francis O. Walker, and Mark J. Warburton. "Ulnar Nerve Enlargement at the Medial Epicondyle Negatively Correlates With Nerve Conduction Velocity in Cubital Tunnel Syndrome." HAND 15, no. 2 (2018): 165–69. http://dx.doi.org/10.1177/1558944718792275.
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Background: In cubital tunnel syndrome (CuTS), chronic compression often occurs at the origin of the flexor carpi ulnaris at the medial epicondyle. Motor nerve conduction velocity (NCV) across the elbow is assessed preoperatively to corroborate the clinical impression of CuTS. The purpose of this study was to correlate preoperative NCV to the direct measurements of ulnar nerve size about the elbow at the time of surgery in patients with clinical and/or electrodiagnostic evidence of CuTS. Methods: Data from 51 consecutive patients who underwent cubital tunnel release over a 2-year period were reviewed. Intraoperative measurements of the decompressed nerve were taken at 3 locations: at 4 cm proximal to the medial epicondyle, at the medial epicondyle, and at the distal aspect of Osborne fascia at the flexor aponeurotic origin. Correlation analysis was performed comparing nerve size measurements to slowing of ulnar motor nerve conduction velocities (NCV) below the normal threshold of 49 m/s across the elbow. Results: Enlargement of the ulnar nerve at the medial epicondyle and nerve compression at the flexor aponeurotic origin was a consistent finding. The mean calculated cross-sectional area of the ulnar nerve was 0.21 cm2 above the medial epicondyle, 0.30 cm2 at the medial epicondyle, and 0.20 cm2 at the flexor aponeurotic origin ( P < .001). There was an inverse correlation between change in nerve diameter and NCV slowing ( r = −0.529, P < .001). Conclusions: For patients with significantly reduced preoperative NCV and clinical findings of advanced ulnar neuropathy, surgeons can expect nerve enlargement, all of which may affect their surgical decision-making.
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Puneet, Nag, Raj Prajapati Gopal, and Mathur Anshu. "Comparing Diabetic Neuropathy Examination Scores and Nerve Conduction Velocity in Patients with Diabetic Neuropathy." International Journal of Pharmaceutical and Clinical Research 16, no. 6 (2024): 2342–45. https://doi.org/10.5281/zenodo.13364201.
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This study examined the efficacy of Diabetic Neuropathy Examination (DNE) scoring and Nerve Conduction Velocity (NCV) in the diagnosis and monitoring of diabetic neuropathy over 1.5 years. The research was conducted on a sample of 100 patients at Dr. S. N. Medical College in Jodhpur. The findings revealed a notable rise in DNE scores and a decline in NCV, with a robust negative correlation (r = -0.72) between the two, suggesting the progressive nature of neuropathy. The study emphasizes the importance of using DNE scoring and NCV together to provide a thorough evaluation and treatment of diabetic neuropathy. It suggests incorporating these methods into regular clinical practice to enhance patient outcomes. This approach promotes timely intervention and customized treatment strategies, improving the overall management of complications related to diabetes.
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Palve, Suchitra Sachin, and Sachin Bhaskar Palve. "Impact of Aging on Nerve Conduction Velocities and Late Responses in Healthy Individuals." Journal of Neurosciences in Rural Practice 09, no. 01 (2018): 112–16. http://dx.doi.org/10.4103/jnrp.jnrp_323_17.
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ABSTRACT Background: Nerve conduction studies are performed to diagnose the disorders of the peripheral nervous system. The reference values for nerve conduction velocity (NCV) and late responses for different nerves considerably vary in different group and type of population. Physiological factors such as age, temperature, height, and gender affect the NCV. However, there are very few studies which show the age group at which these changes become significant. Aim and Objectives: The aim of the study was to establish the electrophysiological data of the specific age group at which changes in NCV as well as late responses of median common peroneal nerve and also see the late response in the form of F-waves and H-reflex. Methodology: Study groups were divided into three categories based on the age: Group I (18–30 years) (n = 80), Group II (31–45 years) (n = 43), and Group III (46–60 years) (n = 27). Out of which, 93 patients were male and 57 were female. The NCVs were determined for median, common peroneal nerve (motor component and sensory component) along with late responses in the form of H-reflex and F-waves. Results: The mean and standard deviation of median, ulnar, peroneal, and tibial nerve was studied for latencies, amplitude, and velocities for both sensory and motor components. Patients with older age had longer latencies, smaller amplitudes, and slower conduction velocities compared with the younger age group. The change with age was greater in sensory nerve conduction and late responses in all the peripheral nerves. Conclusions: Aging has a definite correlation with the NCV and late responses of different peripheral nerves. There is a need to have reference values with relation to age.
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Hathaiareerug, Chanasak, and Niksa Tanongsakmontri. "DIAGNOSTIC VALUE OF MEDIAN NERVE CONDUCTION VELOCITY ACROSS WRIST AMONG PATIENTS WITH SUSPECTED CARPAL TUNNEL SYNDROME." Journal of Southeast Asian Medical Research 7 (May 13, 2023): e0159. http://dx.doi.org/10.55374/jseamed.v7.159.
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Background: Carpal Tunnel Syndrome (CTS) is the most prevalent type of compressive neuropathy. At present, electrodiagnosis is considered the gold standard in diagnosing CTS. However, no clear cutoff point has been established regarding the diagnostic value of the median nerve conduction velocity, across the carpal tunnel area, among patients with CTS.
 Objectives: This study aimed to determine the cutoff point for patients’ median nerve conduction velocity (NCV), to diagnose CTS among suspected patients, which is determined using electrical stimulations conducted across the carpal tunnel area. The present study also aimed to determine the diagnostic value of the median nerve conduction velocity across the carpal tunnel area, compared with the standard method.
 Methods: This cross-sectional study was conducted among 56 participants (106 wrists) suspected of CTS. Motor and sensory NCV across the carpal tunnel was investigated to yield diagnostic value of CTS compared with the standard technique.
 Results: The optimal cutoff point in diagnosing CTS using the wrist to midpalm conduction velocity, was 40 m/s (with a sensitivity of 87.04% and specificity of 87.18%) for the sensory nerve conduction study, and 35 m/s (with a sensitivity of 88.06% and specificity of 89.74%) for the motor nerve conduction study.
 Conclusion: Our study determined that the optimal cutoff conduction velocities for CTS diagnosis, using the wrist-to-midpalm electrical stimulation method, was 40 m/s for the sensory nerve, and 35 m/s for the motor nerve.
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Kruti, Patel, Bachlaus Neeta, and Parmar Dharitri. "THE RELATIONSHIP BETWEEN NERVE CONDUCTION STUDY AND LONG WORKING HOURS IN COMPUTER WORKERS." International Journal of Basic and Applied Physiology 7, no. 1 (2018): 66–71. https://doi.org/10.5281/zenodo.4481448.
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Background: Increase of computer work coincided with a decreased nerve conduction velocities of peripheral nerves (median and ulnar). Objective: Aim of study is to measure the abnormality of nerve conduction entrapment of the median and ulnar nerves in the mouse-operating limb. Material and Methods: Nerve conduction study was performed on 60 computer operators: group I, with 30 right handed office workers who worked at a computer for minimum of 6 - 8 hours per day in the college; and group II, with 30 right handed individuals who worked at computer for < 2 hours/ week. Results: We observed decreased conduction velocity in median and ulnar nerve of both motor and sensory division in computer operators working for 6-8 hours/day. Conclusion: NCV is a simple, reliable, and sensitive tool to measure and describe nerve conduction entrapment abnormality.
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Ul Haque, Muhammad Z., Peng Du, and Leo K. Cheng. "A combined functional dorsal nerve model of the foot." Mathematical Biosciences and Engineering 19, no. 9 (2022): 9321–34. http://dx.doi.org/10.3934/mbe.2022433.
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<abstract> <p>The nerves in the skin surface of the foot are comprised of unmyelinated smaller somatic nerves and larger myelinated sensory nerves. Current diagnostic methods are unable to evaluate combined nerve conduction velocity (NCV) from both unmyelinated smaller somatic nerve (USSN) and myelinated larger nerves (MLN) respectively. Computational models may provide an alternative tool to determine the NCV of the combined nerve. Therefore, a combined functional dorsal nerve model (CFDNM) of the various dorsal nerves along with its associated nerve ending of the human foot is proposed and constructed. The combined dorsal nerve model consists of synthetic USSN (SUSSN) and dorsal MLN of the foot. The unmyelinated as well as myelinated electrophysiological nerve models were used to simulate selected SUSSN and MLN of the foot by injecting an external stimulus at the most distal part of SUSSN of the foot through the use of bidomain model. Results from our work demonstrated that the action potential propagated from the most distal part to proximal part of distinct dorsal nerves of the foot, e.g., the simulated NCV of the combined intermediate dorsal cutaneous nerve (IDCN) of the foot was 28.4 m s<sup>-1</sup>. The CFDNM will provide a vital tool for diagnosis initially small fibre neuropathy (SFN) by computing NCV in the prospective studies.</p> </abstract>
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Silva, Paula Fabiana Sobral da, Maria Carolina Martins de Lima, José Natal Figueiroa, and Otávio Gomes Lins. "Temporal branch of facial nerve: a normative study of nerve conduction." Arquivos de Neuro-Psiquiatria 68, no. 4 (2010): 619–22. http://dx.doi.org/10.1590/s0004-282x2010000400026.
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The temporal branch of the facial nerve is particularly vulnerable to traumatic injuries during surgical procedures. It may also be affected in clinical conditions. Electrodiagnostic studies may add additional information about the type and severity of injuries, thus allowing prognostic inferences. The objective of the present study was to develop and standardize an electrophysiological technique to specifically evaluate the temporal branch of the facial nerve. METHOD: Healthy volunteers (n=115) underwent stimulation of two points along the nerve trajectory, on both sides of the face. The stimulated points were distal (on the temple, over the temporal branch) and proximal (in retro-auricular region). Activities were recorded on the ipsilateral frontalis muscle. The following variables were studied: amplitude (A), distal motor latency (DML) and conduction velocity (NCV). RESULTS: Differences between the sides were not significant. The proposed reference values were: A >0.4 mV, DML <3.9 ms and NCV >40 m/s. Variation between hemifaces should account for less than 60% for amplitudes and latency, and should be inferior to 20% for conduction velocity. CONCLUSION: These measurements are an adequate way for proposing normative values for the electrophysiological evaluation of the temporal branch.
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Paunikar, Vaishali. "Peripheral neuropathy in severe iron deficiency anemia: A case report." Journal of School of Advanced Studies 5, no. 1 (2022): 26–28. http://dx.doi.org/10.54054/jsas.2022518.
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Anemia is a global health problem that need medical attention. Iron deficiency anemia (IDA), in particular is the most common nutritional deficiency anemia prevalent in India. Iron essential for effective myelination of peripheral nervous system.1 Nerve conduction studies are one of the neurophysiological investigations that can quantitatively detect peripheral nerve dysfunction.2 In this case report, we present findings of nerve conduction studies performed on a case of severe iron deficiency anemia and the associated peripheral neurodeficit observed in the case study. Nerve conduction study (NCS) was performed in bilateral median and ulnar motor and sensory nerves. CMAP (compound muscle action potential) and SNAP(sensory nerve action potential) and motor and sensory NCV (nerve conduction velocity) was decreased and the distal latency was prolonged in both ulnar and median nerves. These observations indicate a sensorimotor demyelinating and axonal peripheral neuropathy in the patient due to iron deficiency.
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Khalid, Naman, Msy Rita Dewi, RM Indra, et al. "Nerve conduction parameters in children with severe acute malnutrition treated with standard nutritional therapy." Paediatrica Indonesiana 65, no. 1 (2025): 54–60. https://doi.org/10.14238/pi65.1.2025.54-60.
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Background Nerve damage has been found in malnourished patients due to deficiencies in micronutrients and macronutrients. Studies on nerve conduction in malnourished children are scarce, specifically those comparing nerve conduction parameters before and after nutritional intervention, are few. Objective To identify nerve conduction changes in children with severe acute malnutrition (SAM) treated with standard nutritional therapy. Methods This was a one-group pretest-posttest quasi-experimental study on children with SAM aged 1 month to 18 years who received standard nutritional therapy for 3 months. We recorded anthropometric data and measured motor and sensory nerve conduction velocity (NCV) of the upper and lower limb nerves before and after the nutritional intervention. Results Thirty participants were included in the study; only 27 underwent post-treatment follow-up nerve conduction testing. All anthropometric indices increased after the intervention, except for body length/height. Moderate correlations were observed between pre-intervention weight and NCVs of the right sural sensory (r=0.496; P=0.005) and left median motor (r=-0.502; P=0.024) nerves. After intervention, conduction velocities of the left median sensory nerve (r=0.750; P=<0.001), right median motor nerves (r=0.521; P=0.015), left ulnar motor nerves (r=0.628; P=0.005), and left tibial motor nerves (r=0.419; P=0.047), had moderate to strong correlations with weight. There were moderate post-treatment correlations between BMI and NCV in the right ulnar (r=0.534; P=0.013) and right fibular (r=0.441; P=0.031) motor NCVs. Conclusion There are significant correlations between weight and some motor and sensory NCVs, as well as between BMI and motor NCVs, after 3 months of receiving nutritional therapy.
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Anantharaman, Ganapathy, Dhanalakshmi.Y, .T Chitra, Marie Feula A. Jothi, and Kumar.B Arun. "ASSESSMENT OF SENSORY NERVE CONDUCTION IN ANAEMIC SOUTH INDIAN WOMEN." International Journal of Basic and Applied Physiology 8, no. 1 (2019): 52–56. https://doi.org/10.5281/zenodo.4483346.
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<strong>Background & objectives</strong>: Anaemia is a major health problem worldwide, as it affects nearly 500 million women and more than 1 billion women are at risk. Anaemia also leads to defects in neurotransmitter development and myelination which can slow down the conduction rate in neurons. This study was aimed to assess Sensory nerve conduction of median nerve in upper limb and Sural nerve in lower limb, to compare the sensory nerve conduction velocity (NCV) and amplitude between anaemic and non anaemic women and to correlate nerve conduction velocity and haemoglobin concentration. <strong>Methods</strong>: This was a cross sectional study. Individuals who met the inclusion criteria were recruited into the study. The subjects were screened for Complete Blood Count (CBC) Parameters and were selected accordingly. The Haemoglobin concentration was estimated using auto analyser by Spectrophotometry method. For this 2 mL of venous blood was withdrawn from the volunteers following aseptic precautions. The number of volunteers screened were 45. The numbers of volunteers recruited into study group were 33. Nerve conduction studies for the study and control subjects were conducted at the Electrophysiology lab, Department of Physiology. Sensory nerve conduction of the median nerve in upper limb and sural nerve in Lower limb were studied.<strong> Interpretation and Results</strong>: Subjects in the study and control groups were age, height and weight matched. Sensory nerve conduction velocity of median nerve was significantly reduced and the latency was prolonged in study group when compared to the control group. In sural nerve, the conduction velocity was reduced in the study group.<strong> Conclusion</strong>: We conclude from our study that, due to decreased myelination and decreased rate and amount of neurotransmitter synthesis, The Nerve conduction Velocity of peripheral nerves decrease and their latencies increase in Anaemic women when compared to Non-Anaemic women.
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Richards, Jim, Antonin Gechev, Jill Alexander, Liane Macedo, Karen A. May, and Steven B. Lindley. "The Effect of Local Cooling at the Elbow on Nerve Conduction Velocity and Motor Unit Behaviour: An Exploration of a Novel Neurological Assessment." Sensors 21, no. 20 (2021): 6703. http://dx.doi.org/10.3390/s21206703.
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Background: This study aimed to determine the effects of a standard therapeutic cooling protocol using crushed ice on the elbow to explore if changes in the motor unit (MU) firing rates in the first dorsal interosseous (FDI) muscle are comparable to known changes in sensory and motor nerve conduction velocity (NCV) due to a regional temperature drop around a peripheral nerve. Methods: Twelve healthy individuals were assessed before cooling, immediately after cooling, and 15 min of rewarming. Assessments included two standard non-invasive nerve conduction velocity tests and a non-invasive investigation of the MU firing rates using surface electromyography decomposition (dEMG). Results: Repeated ANOVAs showed significant differences in the MU firing rates and NCV between time points (p = 0.01 and p < 0.001). All measures showed significant differences between pre and post cooling and between pre-cooling and 15 min of passive re-warming, however, no changes were seen between post cooling and rewarming except in the sensory NCV, which increased but did not return to the pre-cooled state. Conclusions: This current study showed a significant, temporary, and reversible reduction in ulnar NCV across the elbow in healthy subjects, which was associated with a significant decrease in mean MU firing rates in the FDI muscle.
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Yu, Cai-Guo, Fang-Fei Wei, Wen-Yi Yang, et al. "Heart rate variability and peripheral nerve conduction velocity in relation to blood lead in newly hired lead workers." Occupational and Environmental Medicine 76, no. 6 (2019): 382–88. http://dx.doi.org/10.1136/oemed-2018-105379.
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ObjectivesPrevious studies relating nervous activity to blood lead (BL) levels have limited relevance, because over time environmental and occupational exposure substantially dropped. We investigated the association of heart rate variability (HRV) and median nerve conduction velocity (NCV) with BL using the baseline measurements collected in the Study for Promotion of Health in Recycling Lead (NCT02243904).MethodsIn 328 newly hired men (mean age 28.3 years; participation rate 82.7%), we derived HRV measures (power expressed in normalised units (nu) in the high-frequency (HF) and low-frequency (LF) domains, and LF/HF) prior to long-term occupational lead exposure. Five-minute ECG recordings, obtained in the supine and standing positions, were analysed by Fourier transform or autoregressive modelling, using Cardiax software. Motor NCV was measured at the median nerve by a handheld device (Brevio Nerve Conduction Monitoring System, NeuMed, West Trenton, NJ, USA). BL was determined by inductively coupled plasma mass spectrometry.ResultsMean BL was 4.54 µg/dL (IQR 2.60–8.90 µg/dL). Mean supine and standing values of LF, HF and LF/HF were 50.5 and 21.1 nu and 2.63, and 59.7 and 10.9 nu and 6.31, respectively. Orthostatic stress decreased HF and increased LF (p<0.001). NCV averaged 3.74 m/s. Analyses across thirds of the BL distribution and multivariable-adjusted regression analyses failed to demonstrate any association of HRV or NCV with BL.ConclusionsAt the exposure levels observed in our study, autonomous nervous activity and NCV were not associated with BL.Trial registration numberNCT02243904
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Onapito, John S., Marc R. Raffe, and Victor S. Cox. "Pressure-induced changes in fibular motor nerve conduction velocity and fibularis (peroneus) tertius muscle-evoked potentials in a goat model of the downer cow syndrome." American Journal of Veterinary Research 47, no. 8 (1986): 1747–50. https://doi.org/10.2460/ajvr.1986.47.08.1747.
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SUMMARY A study was conducted to determine the acceptable fibular motor nerve conduction velocity (ncv) in goats and to characterize pressure-induced changes in conduction velocity and muscle-evoked potentials (mep). The acceptable motor ncv in the adult goat was determined to be 95.9 ± 6.8 m/s. Limb compression in recumbent cows was modeled by application of external compression to the goat pelvic limb to increase im pressure to a minimum of 50 mm of Hg. This pressure, when applied for a 6-hour period, caused a 30% to 100% reduction of fibular motor ncv and a 10% to 100% reduction of amplitude of mep measured from fibularis (peroneus) tertius muscle. The reduction of motor ncv and mep was associated with clinically evident limb dysfunction. The changes detected by the electrodiagnostic tests were proportional to the magnitude and duration of the locomotor deficits. The limb dysfunction was accompanied by muscular damage indicated by an increase of serum creatine kinase activity.
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Kumar, Sandeep, Manjeet Singh, Tarun Tarun, Jeewandeep Kaur, and Swaran Kaur Saluja. "TO STUDY NERVE CONDUCTION PARAMETERS IN PREDIABETICS AND HEALTHY INDIVIDUALS." International Journal of Advanced Research 13, no. 01 (2025): 557–72. https://doi.org/10.21474/ijar01/20229.
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Background: It has been found in various observational studies done till now that many micro and macro vascular complications start developing earlier to the diagnosis of T2DM. So, it becomes very important to diagnose this earlier stage of T2DM i.e. Prediabetes. It is at this stage when one can prevent progression of Pre diabetes to frank T2DM. Objective: Primiray Objective:To compare Nerve Conduction parameters in Prediabetics and healthy individuals (sensory and motor nerve). Secondary Objective:To correlate HbA1c with nerve conduction parameters in Prediabetic individuals. Material And Methods: A study on nerve conduction was conducted on the motor median, motor ulnar, motor tibial, sensory median and sural nerves. Prediabetic cases and healthy controls not associated with any pathology mentioned in exclusion criteria were included in the study. Their clinical history had taken and all routine and special investigations have carried out as per patient proforma. After collecting the blood samples, patients were referred from medicine to Physiology department for nerve conduction study, in which NCV parameters (Nerve conduction velocity and amplitude) were recorded.After explaining the purpose of the study and requisite details regarding the same, written informed consent was obtained from all patients as per ethical board guidelines. Control Group (Group 1): comprise of 65 healthy individuals (NGT). Prediabetic Group (Group 2): comprise of 65 individuals diagnosed with prediabetes (IGT). Results: Ncv and Amplitude was reduced in prediabetics compared to healthy individuals.Significantnegativecorrelation was found between HbA1cand nerve conduction parameters in Prediabetic individuals. Conclusion: By diagnosing it early in the course of prediabetes, morbidity and mortality secondary to neuropathy can be prevented. It may assist the physicians in early detection of nerve damage and to start timely intervention, if required to prevent further complications. So, it is suggested that nerve conduction study should be inducted in routine investigations of prediabetic cases for early diagnosis of cognitive decline.
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Ege, Fahrettin, Gülhan Sarıçam Yapar, and Memet Aslanyavrusu. "Normative Values of Whole Plantar Nerve Conduction Study in Healthy Individuals." Neurological Sciences and Neurophysiology 42, no. 1 (2025): 1–6. https://doi.org/10.4103/nsn.nsn_132_24.
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ABSTRACT Introduction: Whole plantar nerve conduction study (WPNCS) is the method, in which medial and lateral plantar nerves are stimulated simultaneously with appropriate surface electrodes, and compound nerve action potentials (CNAPs) are recorded with bipolar surface electrodes proximal to the flexor retinaculum. Our aim was to determine normative values of nerve conduction study results. Methods: The study included 90 healthy volunteers of both sexes aged between 18 and 60 years. To record CNAPs, a bipolar disc electrode was placed in a proximal position near the flexor retinaculum on the ankle. Medial and lateral plantar nerves were stimulated simultaneously from the anterior transverse arch of the sole. Results: The mean CNAP amplitude was 22.82 ± 8.16 (95% confidence interval [CI]: 21.62–24.02) μV, with a lower limit of 10.1 and a 5th percentile value of 11.69. The mean CNAP maximum nerve conduction velocity (NCV) was 58.33 ± 5.47 (95% CI: 57.52–59.13) m/s, with a lower limit of 45.2 and a 5th percentile value of 50.0. The mean CNAP negative peak NCV was 42.95 ± 3.67 (95% CI: 42.41–43.49) m/s, with a lower limit of 34.6 and a 5th percentile value of 37.0. Conclusion: This study represents an electrophysiology investigation to determine normative values in a large number of volunteers with a slight technical modification after the description of the WPNCS method in 2015. It is anticipated that these limit values will be employed in the future for the diagnosis of peripheral nervous system pathologies.
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Ishibashi, Fukashi, Rie Kojima, Miki Taniguchi, Aiko Kosaka, Harumi Uetake, and Mitra Tavakoli. "The Expanded Bead Size of Corneal C-Nerve Fibers Visualized by Corneal Confocal Microscopy Is Associated with Slow Conduction Velocity of the Peripheral Nerves in Patients with Type 2 Diabetes Mellitus." Journal of Diabetes Research 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/3653459.
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This study aims to establish the corneal nerve fiber (CNF) morphological alterations in a large cohort of type 2 diabetic patients and to investigate the association between the bead size, a novel parameter representing composite of accumulated mitochondria, glycogen particles, and vesicles in CNF, and the neurophysiological dysfunctions of the peripheral nerves. 162 type 2 diabetic patients and 45 healthy control subjects were studied in detail with a battery of clinical and neurological examinations and corneal confocal microscopy. Compared with controls, patients had abnormal CNF parameters. In particular the patients had reduced density and length of CNF and beading frequency and increased bead size. Alterations in CNF parameters were significant even in patients without neuropathy. The HbA1c levels were tightly associated with the bead size, which was inversely related to the motor and sensory nerve conduction velocity (NCV) and to the distal latency period of the median nerve positively. The CNF density and length positively correlated with the NCV and amplitude. The hyperglycemia-induced expansion of beads in CNF might be a predictor of slow NCV in peripheral nerves in type 2 diabetic patients.
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Gupta, Rashmi, Shalini Sharma, Raj Kumar Sharma, and Saurabh Sharma. "Effect of Neurodynamic Mobilisation Plus Core Stability on Pain and Motor Nerve Conduction Velocity in Athletes with Lumbar Radiculopathy." Polish Journal of Sport and Tourism 28, no. 3 (2021): 3–7. http://dx.doi.org/10.2478/pjst-2021-0013.
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Abstract Introduction. Lumbar radiculopathy (LR) is a common debilitating disorder of neuromuscular origin that affects athletes. Material and Methods. This study was a parallel group design and a total of 24 clinically diagnosed athletes with LR were recruited for the study and randomly assigned to one of the two groups, i.e. neurodynamic mobilisation plus core stability group (NDS plus CS) and core stability group only (CS). NDS plus CS underwent neural mobilisation of the tibial nerve and core stability exercises, while CS group performed core stability for a total of 14 sessions on alternate days. The outcome measures of motor nerve conduction velocity (m NCV) of the tibial nerve and pain intensity were recorded before the start of the intervention, at midpoint (7th session) and at the end of the intervention (14th session). Results. Baseline scores of pain and m NCV (NDS plus CS: 6.75 ± 0.62, 38.10 ± 7.21 and CS: 6.58 ± 0.79, 38.92 ± 6.37) were non-significant. The outcome measures improved significantly during treatment in NDS plus CS group (baseline to 7th session, 7th to 14th session and overall mean change for pain and m NCV was found to be 4.74 ± 0.37 and -6.43 ± 3.08, respectively. Non-significant improvement was reported for CS group. Two-way repeated measures (2 x 3) ANOVA was used to analyse the change in the outcome measures and revealed that NDS plus CS group showed statistically significant main effects for group on pain level (F (2, 5.34) = 0.89, p < 0.001 and m NCV (F (2, 5.21) = 0.40, p < 0.03. Significant time and group x time interaction effects were also found. Conclusions. The findings of the study revealed that neurodynamic mobilisation plus core stability were found effective in improving pain level and motor nerve conduction velocity of the tibial nerve in athletes with lumbar radiculopathy.
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Prasad, Dr Manish A., Dr Rakesh Peshane, Dr S. Z. Quazi, and Dr Abhay Mudey. "A comparative study to assess Nerve Conduction Velocity (NCV) test among agricultural workers who sprayed pesticide and non- agriculture workers in Wardha District in Central India." International Journal of Medical Science and Clinical invention 7, no. 01 (2020): 4707–13. http://dx.doi.org/10.18535/ijmsci/v7i01.07.
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Background: Pesticides are very harmful for human health especially for farmers who are more in contact with them.
 Objective: To compare Nerve Conduction Test among agricultural workers exposed to pesticide and non-agricultural workers.
 Method: A sample size of 83 in each group was selected. A pretested questionnaire was prepared comprising of socio-demographic profile, work practices followed by agricultural pesticide sprayers, detail clinical history & findings of Nerve Conduction Test.
 Result: The mean Latency in occasional pesticide sprayer was 3.12 ± 0.95 and in regular pesticide sprayer was 3.88 ± 1.08, on applying student t test the result was observed to be significant. The mean conduction velocity in occasional pesticide sprayer was 52.95 ± 11.28 and regular pesticide sprayer was 43.96 ± 12.34, on applying student t test the result was significant.
 Conclusion: agricultural workers, pesticide sprayers, nerve conduction test, occupational health
 Keywords: Pesticide, agriculture workers, Nerve Conduction Velocity (NCV) test, Personal Protective Equipments (PPE).
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Aida Fitri, Aida Fitri, Hasan Sjahrir Hasan Sjahrir, Adang Bachtiar Adang Bachtiar, and Muhammad Ichwan Muhammad Ichwan. "Effect of Vitamin D on Aldose Reductase in Indonesian Diabetic Polyneuropathy Patients a Randomized Clinical Trial." Sains Malaysiana 51, no. 1 (2022): 209–15. http://dx.doi.org/10.17576/jsm-2022-5101-17.
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Aldose Reductase (AR) is an important factor in the pathogenesis of several Diabetes Mellitus (DM) complications, including diabetic neuropathy (DN). Vitamin D has a direct effect on the pathogenesis of DN. Aldose reductase inhibition is an important element in the prevention of DM complications. The objective of this paper was to assess the effect of vitamin D on AR in Indonesian diabetic polyneuropathy (DPN) patients. This cohort study was undertaken at Haji Adam Malik General Hospital Medan, North Sumatera, Indonesia. In a double-blind, placebo-controlled, clinical trial, eligible patients were randomized to receive vitamin D 50,000 IU/week or placebo for 10 weeks. The primary end-point was mean changes of nerve conduction velocity (NCV) from baseline and after 10 weeks of supplementation. There was no significant correlation between mean changes of vitamin D and AR levels. There was significant correlation with negative direction and weak strength between mean changes of AR level and NCV of motor Tibial nerve (p<0.05; r=-0.337). There was significant correlation with positive direction and moderate strength between mean changes of vitamin D level and NCV of motor Median and Peroneal nerves, and motor and sensory Ulnar nerves (p<0.001; r=0.438 – 0.527). In conclusion, vitamin D supplementation had no effect on AR level in Indonesian DPN patients. Higher AR level was correlated with decreased NCV of motor Tibial nerve. Vitamin D supplementation improved NCV in DPN.
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Morimoto, Jiro, Yutaka Suzuki, Ai Tada, Megumi Akui, Yuri Ozawa, and Taro Maruyama. "Time-course changes in nerve conduction velocity (NCV) in type 2 diabetes." Journal of Diabetes and its Complications 26, no. 3 (2012): 237–40. http://dx.doi.org/10.1016/j.jdiacomp.2012.03.008.
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Schamarek, Imke, Christian Herder, Bettina Nowotny, et al. "Adiponectin, markers of subclinical inflammation and nerve conduction in individuals with recently diagnosed type 1 and type 2 diabetes." European Journal of Endocrinology 174, no. 4 (2016): 433–43. http://dx.doi.org/10.1530/eje-15-1010.
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ObjectiveSubclinical inflammation has been implicated in the development of diabetic sensorimotor polyneuropathy (DSPN), but studies using electrophysiological assessment as outcomes are scarce. Therefore, we aimed to investigate associations of biomarkers reflecting different aspects of subclinical inflammation with motor and sensory nerve conduction velocity (NCV) in individuals with diabetes.Design and methodsMotor and sensory NCV was assessed in individuals with recently diagnosed type 2 (n=352) or type 1 diabetes (n=161) from the baseline cohort of the observational German Diabetes Study. NCV sum scores were calculated for median, ulnar and peroneal motor as well as median, ulnar and sural sensory nerves. Associations between inflammation-related biomarkers, DSPN and NCV sum scores were estimated using multiple regression models.ResultsIn type 2 diabetes, high serum interleukin (IL)-6 was associated with the presence of DSPN and reduced motor NCV. Moreover, higher levels of high-molecular weight (HMW) adiponectin, total adiponectin and their ratio were associated with prevalent DSPN and both diminished motor and sensory NCV, whereas no consistent associations were observed for C-reactive protein, IL18, soluble intercellular adhesion molecule-1 and E-selectin. In type 1 diabetes, only HMW and total adiponectin showed positive associations with motor NCV.ConclusionsOur results point to a link between IL6 and both DSPN and slowed motor NCV in recently diagnosed type 2 diabetes. The reverse associations between adiponectin and NCV in type 1 and type 2 diabetes are intriguing, and further studies should explore whether they may reflect differences in the pathogenesis of DSPN in both diabetes types.
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A, Lalithamma, Vadivel S, Johnson W, Jacob V, and Chitra T. "EFFECT OF NERVE CONDUCTION STUDIES IN HYPOTHYROIDISM - AN OBSERVATIONAL STUDY." Asian Journal of Pharmaceutical and Clinical Research 11, no. 8 (2018): 326. http://dx.doi.org/10.22159/ajpcr.2018.v11i8.25696.
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Objective: This observational study was conducted during the year 2016–2017 to assess the electrodiagnostic evidence of peripheral nerve dysfunction among newly diagnosed hypothyroid patients attending a tertiary care hospital and to find the effect of hormonal treatment after short duration. Methods: An observational study was conducted in 25 newly diagnosed hypothyroid patients with the age group of 20–60 were included. After obtaining informed consent, all participants were examined with electrodiagnostic workup performed at the initial time of diagnosis and after short duration for median and ulnar nerves of upper limb by (NeuroStim -NS2, EMG/EP/NCV, and MEDICAID SYSTEMS). Electrophysiological parameters such as distal motor latency, amplitude, and conduction velocity were evaluated. Results: The mean age of study population was 42.7±12.1 (23–61) years. The mean values of nerve conduction velocity of motor and sensory median before the treatment were 42.8±15.7 and 40.13±4.19 and motor and sensory ulnar before treatment were 41.18±22.4 and 39.46±11.9. The mean values of nerve conduction velocity of motor and sensory median after treatment were 53.35±4.7 and 57.3±5.6 and motor and sensory ulnar After treatment were 54.56±2.99 and 54.09±12.17. The result of the study. Shows that there were reduction of conduction velocity before treatment and statistically significant after 3 months duration of treatment with appropriate doses. Conclusion: After treatment, total triiodothyronine, total thyroxin, free triiodothyronine, free thyroxin, thyroid-stimulating hormone, and median and ulnar nerve motor and sensory functions were normal with appropriate treatment. The involvement of sensory fibers is more than that of the motor fibers.
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Herrera, Esperanza, Maria C. Sandoval, Diana M. Camargo, and Tania F. Salvini. "Motor and Sensory Nerve Conduction Are Affected Differently by Ice Pack, Ice Massage, and Cold Water Immersion." Physical Therapy 90, no. 4 (2010): 581–91. http://dx.doi.org/10.2522/ptj.20090131.
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Background It is well known that reducing tissue temperature changes sensory and motor nerve conduction. However, few studies have compared the effect of different cold modalities on nerve conduction parameters. Objective The purpose of this study was to compare the effects of ice pack, ice massage, and cold water immersion on the conduction parameters of the sural (sensorial) and tibial motor nerves. Design An experimental study was conducted in which the participants were randomly assigned to 1 of 3 intervention groups (n=12 per group). Independent variables were cold modality and pre- and post-cooling measurement time. Dependent variables were skin temperature and nerve conduction parameters. Methods Thirty-six people who were healthy, with a mean (SD) age of 20.5 (1.9) years, participated in the study. Each group received 1 of the 3 cold modalities, applied to the right calf region for 15 minutes. Skin temperature and nerve conduction parameters were measured before and immediately after cooling. Results All 3 modalities reduced skin temperature (mean=18.2°C). There also was a reduction in amplitude and an increase in latency and duration of the compound action potential. Ice massage, ice pack, and cold water immersion reduced sensory nerve conduction velocity (NCV) by 20.4, 16.7, and 22.6 m/s and motor NCV by 2.5, 2.1, and 8.3 m/s, respectively. Cold water immersion was the most effective modality in changing nerve conduction parameters. Limitations The cooling area of the ice massage and ice pack was smaller than that of the cold water immersion. The examiner was not blinded to the treatment group. The population included only participants who were healthy and young. Conclusions All 3 modalities were effective in reducing skin temperature and changing sensory conduction at a physiological level that is sufficient to induce a hypoalgesic effect. The results suggest that cold water immersion, as applied in this study, is the most indicated modality for inducing therapeutic effects associated with the reduction of motor nerve conduction.
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Vishwajit, Kumar, Kumar Jha Pawan, and Krishna Prasad Bijay. "Effect of Aging on Nerve Conduction Study of Median Nerve and Ulnar Nerves in Healthy Individuals: A Cross-Sectional Study." International Journal of Pharmaceutical and Clinical Research 16, no. 6 (2024): 593–98. https://doi.org/10.5281/zenodo.12734593.
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<strong>Background: </strong>Numerous physiological and environmental factors are known to have an impact on nerve conduction studies (NCS). The purpose of the current investigation was to ascertain how aging affected the nerve conduction velocity (NCV) of the two often studied upper limb nerves, the ulnar and median, in subjects of varying ages. Moreover, the goal was to gather reference information for use in clinically relevant nerve diagnostic tests. The objectives of this study were to examine how aging affects the median and ulnar nerve’s nerve conduction velocities and to track changes in the NCS of these two nerves in relation to age. <strong>Methods: </strong>In this cross-sectional and observational study, 110 healthy participants (60 males and 50 females) were involved. Medical students and staff members, both teaching and non-teaching, at the ANMMCH in Gaya, Bihar, volunteered to be the study’s subjects between April 2023 and December 2023. Group I (18–30 years old) (n = 38), Group II (31–45 years old) (n = 38), and Group III (46–60 years old) (n = 34) were the age groups into which the subjects were divided. The amplitudes, NCVs, and motor and sensory distal latencies of the ulnar and median nerves were measured, and the results were assessed. <strong>Results: </strong>For both the sensory and motor components, the latencies, amplitudes, and velocities of the median and ulnar nerves were examined, together with their mean and standard deviation. In comparison to the younger age group, patients who were older had longer latencies (median: Motor and sensory P < 0.001, ulnar: Motor = 0.013 and sensory = 0.006), smaller amplitudes (median: Motor P = 0.013 and sensory <0.001, ulnar: Motor P = 0.014, and sensory = 0.008), and slower conduction velocities (median: Motor P < 0.001 and sensory = 0.006, ulnar: Motor P = 0.003 and sensory = 0.069). This change was clearly noticeable in the age group of ≥46 years. The ulnar and median nerves’ sensory nerve conduction changed more with aging. <strong>Conclusion: </strong>The findings of our study show a substantial correlation between age and each of the three nerve conduction characteristics that were measured from both nerves. The findings of routine testing should be compared age-wise in order to improve NCS’s diagnostic sensitivity.
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Karishmabanu, Kazi. "Electrophysiological Evaluation Of Peripheral Nerves In Patients With Chronic Obstructive Pulmonary Disease." International Journal of Basic and Applied Physiology 1, no. 1 (2012): 83–87. https://doi.org/10.5281/zenodo.4468673.
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Background and objectives: COPD is the fourth leading cause of death worldwide1. Due to COPD hypoxaemia occurs which can cause negative effect on peripheral nervous system. The main aim is to evaluate nerve conduction velocity in patients with COPD to find out neuropathy if present and also to find out correlation among Stages of Chronic Obstructive Pulmonary Disease, severity of hypoxemia, Smoking and peripheral neuropathy. Method: For this study 50 cases of COPD having no other apparent pathology that can affect peripheral nerves were included. Their clinical neurological assessment was done and nerve conduction velocity was measured for ulnar, median, sural and peroneal nerves by RMS electromyography. The patients were grouped according to stages of COPD, PaO2 level and smoking history. Results: In this study we found strong positive association of stages of COPD2 and neuropathy. By electromyography, 96% patients were found to have neuropathy, commonly sensory and most commonly affected nerve was sural nerve. Interpretation and conclusion: In this study I found that as severity of disease increases, COPD patients suffer from subclinical neuropathy, so drugs causing neuropathy as adverse reaction should be avoided.
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Kim, Jae Yoon, Eunkyung Kim, Hyung Seok Shim, et al. "Reference Standards for Nerve Conduction Studies of Individual Nerves of Lower Extremity With Expanded Uncertainty in Healthy Korean Adults." Annals of Rehabilitation Medicine 46, no. 1 (2022): 9–23. http://dx.doi.org/10.5535/arm.21170.
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Objective To develop a set of reference standards for tibial motor, common peroneal motor, sural sensory, and superficial peroneal sensory nerve conduction studies (NCSs) with expanded uncertainty in a healthy Korean population.Methods Standardized procedures were conducted for individual lower extremity NCSs of 199 healthy participants in their 20s (n=100) and 50s (n=99). Mean values and expanded uncertainties for parameters were analyzed with thorough consideration of multiple uncertainty factors under the International Guide to the Expression of Uncertainty in Measurement. In addition, side-to-side differences in onset latency, amplitude, and nerve conduction velocity (NCV) were analyzed.Results Mean (reference range) for distal onset latency, baseline to negative peak amplitude, NCV of tibial motor nerve in males in their 20s were 4.3 ms (3.1–5.4 ms), 7.1 mV (3.4–10.9 mV), and 50.7 m/s (42.2–59.3 m/s), respectively; sural sensory nerve baseline to negative peak amplitude in males in their 20s was 21.7 μV (8.3–35.2 μV). Including the aforementioned data, we present a vast dataset of normative mean values and expanded uncertainties for NCSs of the leg in a healthy Korean population. Furthermore, upper limits for normal side-to-side differences for onset latency, amplitude, and NCV of each nerve are suggested.Conclusion To our knowledge, this is the first study to present the reference standards of leg NCSs with consideration for multifactorial uncertainties in an Asian population. We expect these results to help practitioners make reliable and reproducible clinical decisions.
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Martin, J. True. "Letter to the Editor: The Continuing Challenge of Evaluating Carpal Tunnel Syndrome Impairment." Guides Newsletter 5, no. 5 (2000): 3–3. http://dx.doi.org/10.1001/amaguidesnewsletters.2000.sepoct02.
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Abstract The author responds to The Continuing Challenge of Evaluating Carpal Tunnel Syndrome Impairment in the March/April 2000 issue of The Guides Newsletter. Carpal Tunnel Syndrome (CTS) is a clinical diagnosis based on the patient's history and objective findings on examination. Patients present with dull, aching discomfort of the hand, forearm, or upper arm; paresthesias and tingling of the hand; subjective weakness or numbness; and, occasionally, autonomic changes. Nerve conduction velocity studies are highly accurate in documenting median nerve entrapment at the level of the wrists, but this is an anatomic finding and does not mean that the entrapment produces any symptoms. An electrophysiologic study does not predict if or when the median nerve entrapment will become symptomatic, which is based on the patient's history. Electromyography (EMG) and nerve conduction velocity (NCV) studies do not help distinguish among the many etiologies of CTS. EMG/NCV testing can provide significant, highly accurate information regarding the physiologic function of the median nerve at the level of the wrist, but physicians must know how to interpret this information in the clinical setting. [The Editor responds: Several traditional findings of CTS have little or no diagnostic value, and electrodiagnosis is the diagnostic test of choice, although reported sensitivities range from 49% to 84% with specificities of 95% to 97%.]
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Xu, Lingling, Dou Tang, Meiping Guan, Cuihua Xie, and Yaoming Xue. "Effect of High-Fat Diet on Peripheral Neuropathy in C57BL/6 Mice." International Journal of Endocrinology 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/305205.
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Objective. Dyslipidemia may contribute to the development of peripheral neuropathy, even in prediabetics; however, few studies have evaluated vascular dysfunction and oxidative stress in patients with peripheral neuropathy.Methods. Using high-fat diet- (HFD-) induced prediabetic C57BL/6 mice, we assessed motor and sensory nerve conduction velocity (NCV) using a BIOPAC System and thermal algesia with a Plantar Test (Hargreaves’ method) Analgesia Meter. Intraepidermal nerve fiber density and mean dendrite length were tested following standard protocols. Vascular endothelial growth factor-A (VEGF-A) and 12/15-lipoxygenase (12/15-LOX) were evaluated by immunohistochemistry and Western blot, respectively.Results. HFD-fed mice showed deficits in motor and sensory NCV, thermal hyperalgesia, reduced mean dendrite length, and VEGF-A expression in the plantar skin and increased 12/15-LOX in the sciatic nerve (P<0.05compared with controls).Conclusion. HFD may cause large myelinated nerve and small sensory nerve fiber damage, thus leading to neuropathy. The mean dendrite length may be a more sensitive marker for early detection of peripheral neuropathy. Reduced blood supply to the nerves and increased oxidative stress may contribute to the development and severity of peripheral neuropathy.
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Toupchizadeh, Vahid, MohammadSadegh Sedigh Mostofi, and Hassan Arkani. "Comparison of Nerve Conduction Velocity (NCV) In Chronic Renal Failure & Transplanted patients." Pars of Jahrom University of Medical Sciences 1, no. 1 (2004): 20–24. http://dx.doi.org/10.29252/jmj.1.1.5.
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Saha, Ishita, Sujoy P. Bhattacharyya, and Debabrata Bandyopadhyay. "A comparative study of the conduction velocity of motor and sensory fibres of ulnar and median nerves among leprosy patients and normal subjects." International Journal of Research in Medical Sciences 8, no. 6 (2020): 2088. http://dx.doi.org/10.18203/2320-6012.ijrms20202248.
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Background: Leprosy and the associated scourge have affected humanity for thousands of years. One of the most debilitating consequences of leprosy is peripheral neuropathy. Nerve Conduction Velocity study provides us with a non-invasive modality to assess peripheral nerve involvement in leprosy.Methods: With this in mind, a cross-sectional observational study was conducted including 30 leprosy patients as "Cases" and 30 age-matched healthy subjects, not suffering from any kind of neurological disorders, as "Controls". Using a digital electromyography machine, the Latency, Amplitude and Conduction Velocities of Motor and Sensory fibres of Ulnar and Median nerves were recorded. The results were compared among controls and cases using suitable statistical tests (descriptive statistics and significance testing using unpaired t-test).Results: In this study, with regard to Sensory Nerve conduction Velocity (SNCV), statistically very significant difference was noted in case of right (p 0.0011) and left (p 0.0037) ulnar nerves among controls and cases. The difference in the amplitude of Motor Action potential (MAP) with regard to right median nerve, among cases and controls, was also statistically significant (p 0.0127). Further the amplitude of Sensory Nerve Action Potential (SNAP) values were higher among cases compared to controls.Conclusions: As such, the findings of this study (and which is also corroborated by many previous studies) lead us to the conclusion that NCV studies can detect lepromatous neuropathy much before the emergence of frank clinical signs and this type of neuropathy is predominantly demyelinating in nature with occasional axonal loss.
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Lindholm, Bengt, and Richard Tegner. "Deterioration of Peripheral Nerve Function during Continuous Ambulatory Peritoneal Dialysis." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 6, no. 1 (1986): 20–24. http://dx.doi.org/10.1177/089686088600600107.
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Peripheral neuropathy during CAPD, was investigated in 27 nondiabetic patients at the start of CAPD and after a mean of 24 months on CAPD with measurements of nerve conduction velocity (NCV) and vibratory perception threshold (VT). The clinical signs of neuropathy were quantified according to a fixed protocol. During the study period, motor NCV decreased 7% in the median nerve, and 9% in the peroneal nerve (p < 0.05); VT increased 45% in the hand (p < 0.01), and 135% on the foot (p < 0.001); and the clinical status improved in five and deteriorated in 14 patients (NS). We conclude (1) that the neuropathy may deteriorate during CAPD, although it remains mild in most instances, and (2) that the most characteristic finding is a markedly impaired vibratory sensitivity.
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Kiran, Thorat, Goyal Manish, Bansal Priyanka, and Singhal Shefali. "Evaluation of Hazards of Ionizing Radiation on Nerve Conduction in Superior Extremity with Duration of Exposure at Tertiary Care Institute: A Comparative Study." International Journal of Pharmaceutical and Clinical Research 15, no. 4 (2023): 1038–45. https://doi.org/10.5281/zenodo.12677940.
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<strong>Introduction: </strong>Peripheral neuropathies are unfavorable consequences of radiation treatment. Tissue changes due to Radiation Exposure result in inflammation and fibrosis that affect the peripheral nerve and lead to peripheral neuropathies. Since the introduction of numerous new radiologic procedures, uses of radiation are increasing in modern medicine. Radiation exposure of Radiologic Technologists (RTs) is about two times higher than that of other occupation groups in the fields , such as physicians, dentists, dental hygienists, and nurses. For better understanding peripheral nerves functioning Nerve Conduction Study (NCS) are most frequently used in neurophysiological laboratories. <sup>.</sup> we tried to study the effect of chronic radiation exposure on peripheral nerve conduction study parameters in RTs. <strong>Material and Methods: </strong>The Present study is a cross-sectional analytic prospective hospital-based study. In present hospital-based study a sum of 60 individuals were selected, of which all of them were Radiologic Technologists (study group/cases), were grouped upon duration of occupational radiation exposure. Group I-RTs with duration of exposure <10 years averaging 6.27 ± 2.05 years. Group II – RTs with duration of occupational radiation exposure 11-25 years averaging 14.44 ± 3.35 years and Group III – RTs with duration of occupational radiation exposure >20 years averaging 23.60±5.21. The Nerve conduction study parameters were recorded with the help of computerized RMS EMG EP Mark –II, made 2015 machine, Panchkula, Haryana, using conducting jelly and recording electrodes. <strong>Results & Discussion: </strong>We found changes in both sensory and motor nerve conduction study parameters in RTs of different duration of occupational exposure. With increase in duration of exposure nerve distal latencies were increased and, Amplitudes (CMAP/SNAP) and NCV were reduced among group I and III. Group II showed variable results. Nerve Conduction velocity showed a reducing trend with the increasing duration of radiation exposure, this may be due to the reason that Nerve Conduction velocity excludes the individual anthropometric variations. <strong>Conclusion:</strong> Conclusion of our study is that ionizing radiations are harmful to all the body tissues including the peripheral nerves. Radiations appear to cause both demyelination and axonal loss.