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Dissertations / Theses on the topic 'Nerve (Neuroscience)'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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1

Bruno, Martin. "Nerve Growth Factor, Aging and Alzheimer's disease." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18741.

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Since the cholinergic hypothesis of geriatric memory dysfunction was proposed by Bartus and colleagues in 1982, studies conducted in animals and humans so far have failed to obtain evidence for the involvement of NGF in normal Aging and/or in the pathophysiology of Alzheimer's disease (AD). It has been hypothesized that age-related degeneration of basal forebrain cholinergic neurons (BFCN) may be caused by the altered endogenous NGF maturation either by reduced responsiveness to NGF, by reduced NGF transport or by the failure in coupling to second messengers. NGF administered in the CNS of AD

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2

Strochlic, David E. "Molecular and Genetic Analysis of the Vagus Nerve." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467391.

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The vagus nerve serves as a primary neural link between the brain and internal organs, detecting a variety of physiological stimuli and controlling a range of autonomic functions essential to homeostatic regulation. However, despite its fundamental importance, little is known about the repertoire of sensory mechanisms residing in vagal afferents, the cellular logic of information coding within the vagus nerve, and the central representation of internal physiological states. To dissect the neural circuits underlying viscerosensation, we adopted a genome-guided strategy to classify vagal sensor

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3

Longo, Geraldine. "A role for nerve growth factor in arthritic pain." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121208.

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Although chronic pain is the most common symptom of arthritis, relatively little is known about the mechanisms driving it. Upregulation of nerve growth factor (NGF) in inflammatory states has been associated with increased nociception. NGF promotes the growth and survival of sympathetic and primary sensory neurons by exerting its biological activity through its cognate receptor TrkA. Previous research has shown that, in the CNS, NGF is released from cells as a precursor (proNGF) together with the enzymes required for its conversion into the mature form (mNGF) and for its degradation. Interesti

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4

Girolami, Elizabeth Irena. "Anti-inflammatory mechanisms in Wallerian degeneration in injured peripheral nerve." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:8881/R/?func=dbin-jump-full&object_id=92234.

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5

Cheung, Man-hin Matthrew, and 張文騫. "Development of diffusion and functional magnetic resonance imaging techniques for neuroscience." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47147635.

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6

Borthwick, Lindsay. "The regulation and function of interleukin-6 after peripheral nerve transection." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/mq64321.pdf.

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7

Forshee, Danielle L. "Vagus nerve stimulation for reactive attachment disorder." Thesis, Capella University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3637057.

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<p> Reactive Attachment Disorder (RAD) is a potential consequence of pervasive neglectful and unpredictable caregiving behaviors, and has extensive psychological and daunting consequences on the vulnerable and developing young brain. Current treatment strategies for RAD are conspicuously lacking, relying on indiscriminately targeted psychopharmacological therapies with pharmacokinetic and pharmacodynamic complications due to developmental vulnerabilities, and the unavailability of evidence based psychotherapeutic interventions. At present, there is an acute demand for innovative research into

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8

Morrison, Ian. "Analysis of nerve terminal dysfunction in autoimmune neuropathy." Thesis, University of Glasgow, 2008. http://theses.gla.ac.uk/132/.

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In studies on the pathophysiology of the autoimmune neuropathy, Miller Fisher syndrome (MFS), monoclonal antibodies to the disialosyl epitopes on GQ1b, GT1a and GD3 gangliosides have been produced. Antibodies to these complex gangliosides are thought to be crucial in the pathogenesis of MFS. These antibodies have recently been shown to produce complement dependent, glial and/or neuronal injury at mouse neuromuscular junctions (NMJs). Three antibodies (EG1, LB1 and R24) were identified as producing selective terminal Schwann cell (TSC) injury whilst sparing neuronal membranes at NMJs in BALB/c

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9

González, Pérez Francisco J. "Functionalizing artificial nerve guides to promote regeneration and recovery after peripheral nerve injuries." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/382643.

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Las lesiones severas de nervio periférico se caracterizan por la desconexión del soma neuronal con el órgano inervado. Esta desconexión causa una pérdida de control motor, sensitivo y autonómico que conducen a una situación incapacitante para el paciente. Después de una lesión el sistema nervioso periférico tiene la capacidad de regenerar, pero para ello se requiere de un proceso de limpieza en el fragmento distal a la lesión y la promoción de la regeneración a través del extremo proximal. En esta tesis hemos querido centrarnos en el papel de la matriz extracelular en la regeneración de nervi

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10

Boutros, Tarek. "Interferon-beta is a potent promoter of nerve growth factor production by astrocytes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0005/MQ37098.pdf.

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11

Lee, Sena. "ATP and its receptors in nerve injury and repair." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8668.

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Unlike the peripheral nervous system (PNS), adult neurons in the central nervous system (CNS) have limited regenerative capacity after injury. One interesting phenomenon observed nearly four decades ago was that lesion of a peripheral nerve can significantly enhance the regenerative capacity of the central axons of the corresponding dorsal root ganglion (DRG) neurons, termed a ‘conditioning lesion’, but the underlying mechanism is still not fully understood. Since ATP is released after nerve injury and extracellular ATP has a broad range of biological activities, we postulated that ATP might b

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12

Monk, Kelly R. "Consequences of Mast Cell Signaling in Peripheral Nerve." University of Cincinnati / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1147889736.

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13

Maliartchouk, Serguei. "Neurotrophin receptor studies with functional nerve growth factor mimetics." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37772.

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Polypeptide hormone Nerve Growth Factor (NGF) plays a crucial role in the development and maintenance of certain neuronal populations, both within the central and peripheral nervous systems. NGF receptors and the hormone itself have been attractive pharmacological targets in the treatment of several neuropathologies including Alzheimer Disease, ischemia, brain trauma, peripheral neuropathies, neurotoxicity associated with chemotherapy of cancer and chronic inflammatory pain. NGF and its receptors are also expressed in several non-neuronal tissues and participate in their regulation. In additio

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14

Auld, Daniel Scott. "Nerve growth factor modulation of basal forebrain neuron acetylcholine release : new perspectives on a classic interaction." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38452.

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This thesis addresses long- and short-term neurotrophin modulation of basal forebrain cholinergic neurons (BFCNs), focusing on acetylcholine (ACh) release and choline acetyltransferase (ChAT; the enzyme responsible for ACh synthesis) activity. (1) Initially, ACh release was characterized from primary embryonic basal forebrain cultures. Release was vesicular, dependent upon extracellular choline and regulated by negative feedback via M2-like muscarinic receptors. (2) The next step was to determined the long-term (24--96 hour) effects of nerve growth factor (NGF), brain derived neurotrophic fact

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15

Mowla, Seyed Javad. "Differential processing and sorting of nerve growth factor and brain-derived neurotrophic factor in hippocampal neurons." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37790.

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We have examined the biosynthesis, post-translational processing and sorting of neurotrophins in both constitutive and regulated cells infected with a pro-NGF, pro-BDNF and/or pro-NT-3 encoding vaccinia virus. Our results show that: (1) pro-BDNF is generated as a 32 kDa precursor that is N-glycosylated and glyco-sulfated in its prodomain. The precursor undergoes N-terminal cleavage to generate mature BDNF (14 kDa) as well as a truncated form of the precursor (28 kDa). (2) Both 32 and 28 kDa BDNF are released into media and are able to stimulate TrkB auto-phosphorylation. (3) The production of

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16

Personius, Kirkwood Ely 1966. "Degeneration of a muscle following remote nerve damage: Physiological changes and triggering mechanisms." Diss., The University of Arizona, 1998. http://hdl.handle.net/10150/288881.

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Muscle depends on innervation and contraction to maintain a differentiated state. Denervation or disuse, therefore, often leads to muscle atrophy. In grasshoppers, muscle degeneration can also be induced when a hindlimb is lost by autotomy. In this case, the thoracic muscles which degenerate are neither damaged nor denervated, suggesting the existence of transneuronal mechanisms that influence muscle survival. Arbas and Weidner (1991) found that muscle degeneration is induced when the leg nerve (which does not innervate the thoracic muscles) is severed during autotomy. To characterize this aut

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17

Guhde, Isabel C., and Conner Moss. "The Role of Vagal Nerve Stimulation in Mitigating Heart Failure Progression." Digital Commons @ East Tennessee State University, 2021. https://dc.etsu.edu/asrf/2021/presentations/54.

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Cardiovascular disease (CVD) is the leading cause of death worldwide and is expected to increase in prevalence. As a result of the individual and systemic healthcare impacts of CVD, heart failure, and its subsets, focusing on the alleviation of cardiac dysfunction and restoration of autonomic imbalance is paramount. Most research regarding cardiovascular disease is focused on mitigating heart failure from a cardiovascular perspective. However, this review will investigate heart failure from a neuroscientific perspective, highlighting the influence of the renin-angiotensin-aldosterone system, a

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18

Welleford, Andrew. "Autologous Peripheral Nerve Grafts to the Brain for the Treatment of Parkinson's Disease." UKnowledge, 2019. https://uknowledge.uky.edu/neurobio_etds/23.

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Parkinson’s disease (PD) is a disorder of the nervous system that causes problems with movement (motor symptoms) as well as other problems such as mood disorders, cognitive changes, sleep disorders, constipation, pain, and other non-motor symptoms. The severity of PD symptoms worsens over time as the disease progresses, and while there are treatments for the motor and some non-motor symptoms there is no known cure for PD. Thus there is a high demand for therapies to slow the progressive neurodegeneration observed in PD. Two clinical trials at the University of Kentucky College of Medicine (NCT

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19

Kabani, Noor Jehan. "Acetylcholine release in the somatosensory cortex following peripheral nerve injury : a microdialysis and HPLC study." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=39393.

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Acetylcholine has been implicated in the reorganization of cortex using lesion studies. These studies suggest that biochemical changes take place in the cortex following peripheral nerve injury. Using microdialysis, we studied the time-dependent change in the release of acetylcholine in control and sciatic-nerve-sectioned cats. Our first finding was that there is intra-animal variability in the release of acetylcholine. Using each cat as its own control we studied the acetylcholine release on days 1, 3, 5, 7, 9, 11 and 15 after nerve injury. We found that the release of acetylcholine was signi

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20

Battista, Gloria. "The immunocytochemical localization of taurine in developing and adult rabbit retina and optic nerve /." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=69756.

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The retina of a newborn rabbit is not fully mature in terms of morphology, chemical composition or capabilities. Taurine is the predominant component of the free amino acid pool of vertebrate retinas. In the rabbit it is present at birth and increases four-fold by maturity reaching levels close to 50 mM in the adult. However, until the present studies its cellular localization was unknown. This study confirmed the postnatal (PN) increase in retinal taurine levels and examined PN changes in the immunocytochemical localization of retinal and optic nerve taurine. I have localized taurine immunore

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21

Ferguson, Charmaine. "Development of an in vitro model of neuronal differentiation and nerve-target interaction." Thesis, University of Ottawa (Canada), 2006. http://hdl.handle.net/10393/27356.

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My objective was to develop a nerve source for use in a 3-dimensional in vitro model to study neurite extension and target innervation. A hybrid neuroblastoma-DRG cell line (ND-C) with properties of neuronal precursors was examined for its ability to effectively differentiate into neurons, produce extensive neurites, and interact with target cells. Neuronal differentiation of ND-Cs was optimized through a combinatorial approach that involved culturing the cells in the presence of various types of culture media, ECM, and soluble factors in a dose dependent fashion. The proportion of neurons an

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22

Issa, Amalia Mary. "Effects of the protein phosphatase inhibitors calyculin A and okadaic acid at the cholinergic nerve terminal." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0016/NQ44461.pdf.

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23

Jenkins, Robert. "The expression of immediate early genes in neuronal development and regeneration." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260577.

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24

Figueiredo, Bonald Cavalcante de. "Neuronal responses to brain injury : effects of nerve growth factor and acidic fibroblast growth factor on morphological changes and gene expression." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28744.

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The major goal in the work of this thesis was to identify neurotrophic factors (NTFs) capable of rescuing atrophied nucleus basalis magnocellularis (NBM) neurons. Two neurotrophins, brain-derived neurotrophic factor and neurotrophin-3, failed to rescue NBM cholinergic neurons, while a similar dose of acidic fibroblast growth factor (aFGF) was able to rescue them. Notably, lesioned NBM neurons treated with aFGF displayed somata size, as well as neuritic processes (dendrites and axons) and ChAT activity in the NBM similar to sham-operated animals. NBM cholinergic degeneration was consistent with

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25

Berkelaar, J. A. Michelle. "Retinal ganglion cell loss after different types of axotomy in the optic nerve." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=56989.

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To investigate differences in neuronal responses to axotomy in the mammalian central nervous system, I compared the patterns of retinal ganglion cell (RGC) survival after intracranial optic nerve (ON) cut or crush in adult rats. After ON cut, approximately 40% of the RGCs were lost in the second week, followed by a more protracted cell loss, while ON crush gave rise to a slow RGC loss beginning at one week. Retrograde axonal degeneration and macrophage invasion into the ON stump was more marked after ON cut than crush, but progressive retrograde degeneration of axons into the retina did not pr

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26

Huh, You Lim 1980. "Effects of chronic nerve growth factor treatment on synaptic transmission in neurons of the rat medial septum diagonal band of Broca area." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101717.

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Nerve growth factor (NGF) is a neurotrophin important for the survival, growth and function of cholinergic basal forebrain neurons. However, little is known about the function of NGF on other basal forebrain neurons such as glutamatergic or GABAergic neurons. Here, we used neurons from the rat medial septum/diagonal band of Broca (MS-DBB) to test whether chronic exposure to NGF affects the synaptic function of cholinergic, glutamatergic and GABAergic basal forebrain neurons. We isolated single rat MS-DBB neurons in culture, allowing them to establish synaptic contacts onto themselves. One grou

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27

Garofalo, Lorella. "Nerve growth factor- andor monosialoganglioside GM1-induced neuroplasticity in brain of decorticated adult and aged rats." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=41292.

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The ability of two putative trophic agents, nerve growth factor (NGF) and the monosialoganglioside GM1, to induce neurochemical, morphological and behavioral recovery following injury to the adult rat basalo-cortical cholinergic pathway was studied. Treatment of unilaterally decorticated rats with these agents was shown to: attenuate deficits in holinergic markers of the nucleus basalis magnocellularis (NBM), prevent shrinkage of choline acetyltransferase (ChAT)- and p75$ sp{ rm NGFR}$-immunoreactive (IR) NBM neurons, and stimulate cortical ChAT activity and high affinity choline uptake, in a

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Verge, Valerie Mary Kathleen. "Properties of intact and injured sensory neurons with nerve growth factor receptors." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74557.

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The role of nerve growth factor (NGF), a neurotrophic molecule, and its high-affinity receptor in intact and injured adult rat lumbar sensory neurons was examined at a cellular level using quantitative receptor radioautography to localize the NGF high-affinity receptor-positive subpopulation, in conjunction with histochemistry on adjacent sections. The 40-50% of sensory neurons displaying NGF receptors were characterized. Virtually all neurons containing substance P or CGRP were NGF receptor-positive, but not those with somatostatin or thiamine monophosphatase activity. The ability of a neuron

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29

Wang, Yun. "The recurrent inhibition of monosynaptic reflexes and its alteration after peripheral nerve crush in decerebrate rats." Thesis, University of Glasgow, 1995. http://theses.gla.ac.uk/4079/.

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In decerebrate rats, recurrent inhibition between lateral gastrocnemius-soleus (LG-S) and medial gastrocnemius (MG) motor pools was assessed by conditioning monosynaptic reflexes elicited from the cut dorsal roots and recorded either from the LG-S and MG nerves by antidromic volleys delivered to the synergist muscle nerve. The results show that following sciatic nerve crush in both experimental groups there is a significant sustained depression in the level of recurrent inhibition. The reduction in recurrent inhibition observed is less in adult animals when comparisons are made with the result

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30

Brady, Stefen. "A clinicopathological study of inclusion body myositis." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:bf7b9891-3cc1-46c5-bf96-3423a0087b6f.

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Sporadic inclusion body myositis (IBM) is the commonest acquired myopathy in individuals aged over 50 years. Currently, diagnosis is based largely upon specific muscle biopsy findings, though these are thought to lack sensitivity. More recently, many abnormal protein aggregates have been described in IBM and some have been proposed as diagnostic markers. However, their diagnostic utility is untested and how they relate to the pathogenesis is uncertain. The clinical characteristics, pathological findings and disease course in 67 patients with histopathologically diagnosed and clinically diagnos

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31

Tajrine, Dima D. "Effect of nerve growth factor and monosialoganglioside GM1 on non-cholinergic pathways in the cortex of lesioned rats." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=27421.

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In this study, light and electron microscopic quantitative analyses were used to examine whether exogenous nerve growth factor (NGF) and/or monosialoganglioside GM1 treatment could affect non-cholinergic systems in the neocortex of the adult rat brain after a devascularising lesion. The two neuronal systems I looked at were the extrinsic noradrenergic and intrinsic somatostatinergic systems. Immediately after unilateral vascular decortication, adult rats received for seven days, via minipump, vehicle, NGF (12 $ mu$g/day) and/or GM1 (1.5 mg/day) into the cerebroventricular space. Thirty days af

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32

Liu, Jiaqiang. "Do the effects of repetitive transcutaneous electrical nerve stimulation (TENS) on experimental pain cumulate over time?" Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=68203.

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This study investigated the immediate and possible cumulative effects respectively of a single 60 min of TENS and of 10 repeated daily applications on subjective pain sensation and flexion reflex. Twenty young healthy subjects were randomly assigned to a TENS or a placebo group, with 10 in each. TENS or placebo stimulation was applied to the lumbro-sacral region for 60 minutes on 10 treatment days over a two-week period. Before, during and after TENS and placebo stimulation on Day$ sb1$, Day$ sb5$ and Day$ sb{10}$, the FR was elicited by electrically stimulating the sole of subject's right foo

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33

Priest, Christina Marie. "A Biochemical Analysis of the Factors Influencing P0 Oligomerization in Xenopus laevis Peripheral Nerve Myelin." Thesis, Boston College, 2004. http://hdl.handle.net/2345/397.

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Thesis advisor: Daniel A. Kirschner<br>Protein zero (P0), the major structural protein of peripheral nerve myelin, is a ~30 kDa integral membrane glycoprotein consisting of an extracellular domain, a transmembrane domain, and a palmitoylated cytoplasmic domain. In native membranes of Xenopus laevis it exists primarily as a dimer. To determine the effects of glycosylation, acylation, and hydrophobic interactions on protein dimerization, I used SDS polyacrylamide gel electrophoresis (SDS-PAGE), Western blotting, and high-performance thin layer chromatography (HPTLC) to analyze the effects of deg

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34

Pettersson, Jonas. "Biosynthetic conduits and cell transplantation for neural repair." Doctoral thesis, Umeå universitet, Institutionen för integrativ medicinsk biologi (IMB), 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-42440.

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Spinal cord injury results in complete failure of the central neurons to regenerate and is associated with cyst formation and enlargement of the trauma zone. In contrast to the spinal cord, axons in the injured peripheral nerve have the capacity to undergo some spontaneous regeneration. However, significant post-traumatic loss of nervous tissue causing long nerve gap is one of the main reasons for the poor restoration of function following microsurgical repair of injured nerves. The present thesis investigates the effects of biodegradable conduits prepared from fibrin glue and poly-beta-hydrox

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35

Zakutansky, Donald W. "The effect of limb blood flow on peripheral nerve function in adults with type 2 diabetes." [Bloomington, Ind.] : Indiana University, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3324509.

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Thesis (Ph.D.)--Indiana University, School of Health, Physical Education and Recreation, 2008.<br>Title from PDF t.p. (viewed on May 13, 2009). Source: Dissertation Abstracts International, Volume: 69-08, Section: B, page: 4596. Adviser: Janet P. Wallace.

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XIE, WENRUI. "BLOCKADE OF ECTOPIC ACTIVITY AT THE INITIAL STAGE OF PERIPHERAL NERVE INJURY PREVENTS NEUROPATHIC PAIN." University of Cincinnati / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1057691866.

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Shawley, Lucinda. "Women's experiences of Transcutaneous Electrical Nerve Stimulation (TENS) for pain control in labour." Thesis, University of Southampton, 2011. https://eprints.soton.ac.uk/210925/.

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The vision for maternity services focuses on women-centred care with choice, control and promoting normality at its centre, thus emphasising the need to empower women to make choices and decisions regarding their care in labour and birth. Some women will choose the medical model of care, however others prefer to be in control and choose to use non-pharmacological alternatives for pain control in labour such as Transcutaneous Electrical Nerve Stimulation (TENS). TENS has enabled the provision of non-invasive, mobile, self-controlled pain relief for women in labour and is used extensively by wom

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Taylor, Lori Kell. "The identification and characterization of a nerve growth factor-activated Fos kinase from PC12 cells." Case Western Reserve University School of Graduate Studies / OhioLINK, 1994. http://rave.ohiolink.edu/etdc/view?acc_num=case1061215363.

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Kim, Yu Kyung. "Segmental and heterosegmental effects of repeated transcutaneous electrical nerve stimulation (TENS) on voluntary motor functions in spastic hemiparetic subjects." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=22749.

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We conducted two studies to examine the changes in voluntary motor functions in spastic hemiparetic muscles, their relationship to clinical spasticity and the reliability of these measures, as well as to investigate the effects of transcutaneous electrical nerve stimulation (TENS) on spasticity and voluntary motor functions in hemiparetic subjects. In our first study, the alterations in voluntary motor functions in the upper and lower limb muscles of spastic subjects were delineated through a comparative study with age-matched controls. Moreover, the test-retest reliability was evaluated for e

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40

Francoeur, Jason. "Distribution of erbB2, erbB3, and erbB4 in the developing avian nervous system and in mammalian lesioned sciatic nerve and denervated muscle." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23273.

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The neuregulins (GGF/ARIA/NDF/Heregulin) are pleiotrophic growth factors that are involved in the development of the nervous system. The neuregulin receptors, erbB2, erbB3, erbB4, are members of the erbB/epidermal growth factor receptor family of receptor tyrosine kinases. Immunoblot analysis with antisera to peptides derived from the carboxy terminus of erbB2, erbB3, erbB4 demonstrate that the three receptors have unique spatial distribution in the brain and have expression patterns which are differentially regulated during development. At a cellular level, erbB2 and erbB4 are expressed by gl

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Hosking, Kimberley Gowens. "Inhibition of RVLM synaptic activation at peak hyperthermia reduces visceral sympathetic nerve discharge." Thesis, Manhattan, Kan. : Kansas State University, 2010. http://hdl.handle.net/2097/3680.

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Cunningham, Madeleine Elizabeth. "The motor nerve terminal is a novel regulator of anti-ganglioside antibodies in mouse models of autoimmune neuropathy." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6368/.

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Autoimmune neuropathies are a group of conditions resulting from inflammatory attack of the peripheral nervous system (PNS). Guillain-Barré syndrome (GBS), an acute autoimmune neuropathy, presents in both axonal and demyelinating forms. Axonal forms of GBS are caused by autoantibodies which target gangliosides on peripheral nerves. Here, they cause axonal damage via activation of the complement pathway. In ex vivo preparations, anti-ganglioside antibodies have been shown to cause complement-mediated injury to the node of Ranvier and the motor nerve terminal. Of these two vulnerable sites, the

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Suri, Nikita. "Superbursts: Investigation of Abnormal Paroxysmal Bursting Activity in Nerve Cell Networks In Vitro." Thesis, University of North Texas, 2018. https://digital.library.unt.edu/ark:/67531/metadc1157655/.

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Superbursts (SBs) are large, seemingly spontaneous activity fluctuations often encountered in high density neural networks in vitro. Little effort has been put forth to define and analyze SBs which are paroxysmal bursting discharges. Through qualitative and quantitative means, I have described specific occurrences of superbursting activity. A complex of paroxysmal bursting has been termed a "superburst episode," and each individual SB is a "superburst event" which is comprises a fine burst structure. Quantitative calculations (employing overall spike summations and coefficient of variation (CV

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44

Grant, Michael Peter. "Nerve-target interactions in the developing sympathetic nervous system of the rat. Regulation of rat sweat gland secretory function by acetylcholine." Case Western Reserve University School of Graduate Studies / OhioLINK, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=case1059494178.

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Armstrong, Michael G. "Effect of zymosan-induced peritonitis on the expression of substance P in primary sensory neurons and spinal nerve processes." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/honors/328.

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Macrophages and other cells of the innate immune system recognize foreign particles that could be potentially dangerous and respond by initiating an inflammatory response. The biologically active chemical mediators of this response called pro-inflammatory cytokines are produced in various myeloid derived immune cells and can affect other cells of the body. Interleukin-1β, a pro-inflammatory cytokine, has been shown to have direct effects on dorsal root ganglion (DRG) cell bodies including the upregulation and direct release of a nociceptive neurotransmitter called substance P (SP). Using a zym

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Rogers, Edmond A. "Simultaneous Electrophysiological and Morphological Assessment of Impact Damage to Nerve Cell Networks." Thesis, University of North Texas, 2018. https://digital.library.unt.edu/ark:/67531/metadc1157638/.

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A ballistic pendulum impulse generator was used to impact networks in primary culture growing on microelectrode arrays. This approach has the advantage of imparting pure tangential acceleration insults (50 to 300 g) with simultaneous morphological and electrophysiological multichannel monitoring for days before and after the impact. Action potential (AP) production, network activity patterns, and cell electrode coupling of individual units using AP waveshape templates were quantified. Network adhesion was maintained after tangential impacts up to 300g with minimal loss of pre-selected active

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Koneczny, Inga. "Potential mechanisms in MuSK-myasthenia gravis." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:7b81b941-92c0-47ae-a747-62277394638e.

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Autoimmunity is a failure to tolerate circulating or cell surface expressed self antigens,leading to activation of the immune system and attack of self tissues. Muscle-specific kinase (MuSK) myasthenia gravis (MG) is a disease caused by antibodies to MuSK and hallmarked by fatigable muscle weakness. MuSK is a tyrosine kinase that interacts with low-density lipoprotein receptor-related protein 4 (LRP4), resulting in maintenance of the high density of acetylcholine receptors (AChRs) at the neuromuscular junction; this high density is essential for efficient transmission of signals from nerve to

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Maynard, Lance M. "THE ROLE OF NERVE GROWTH FACTOR AND PRE-GANGLIONIC INPUT IN THE REGULATION OF TYROSINE HYDROXYLASE EXPRESSION IN SYMPATHETIC NEURONS." Miami University / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=miami1058455797.

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Liang, Zhifeng. "Understanding Neural Networks in Awake Rat by Resting-State Functional MRI: A Dissertation." eScholarship@UMMS, 2005. http://escholarship.umassmed.edu/gsbs_diss/654.

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Resting-state functional magnetic resonance imaging (rs-fMRI) is a non-invasive neuroimaging technique that utilizes spontaneous low-frequency fluctuations of blood-oxygenation-level dependent (BOLD) signals to examine resting-state functional connectivity in the brain. In the past two decades, this technique has been increasingly utilized to investigate properties of large-scale functional neural networks as well as their alterations in various cognitive and disease states. However, much less is known about large-scale functional neural networks of the rodent brain, particularly in the awake

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Liang, Zhifeng. "Understanding Neural Networks in Awake Rat by Resting-State Functional MRI: A Dissertation." eScholarship@UMMS, 2013. https://escholarship.umassmed.edu/gsbs_diss/654.

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Abstract:

Resting-state functional magnetic resonance imaging (rs-fMRI) is a non-invasive neuroimaging technique that utilizes spontaneous low-frequency fluctuations of blood-oxygenation-level dependent (BOLD) signals to examine resting-state functional connectivity in the brain. In the past two decades, this technique has been increasingly utilized to investigate properties of large-scale functional neural networks as well as their alterations in various cognitive and disease states. However, much less is known about large-scale functional neural networks of the rodent brain, particularly in the awake

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