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Dissertations / Theses on the topic 'Nerves Dendrites'

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Published: 4 June 2021

Last updated: 1 February 2022

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1

De, La Garza Richard. "Determination of neuronal morphology in spinal monolayer cultures." Thesis, University of North Texas, 1989. https://digital.library.unt.edu/ark:/67531/metadc798395/.

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The objective of the completed research was to characterize the morphology of individual neurons within monolayer networks of fetal mouse spinal tissue via intraperikaryal injections of horseradish peroxidase (HRP). Thirty labelled neurons were reconstructed via camera lucida drawings and morphometrically analyzed.

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2

Hill, Donna Monique. "Mechanism of centaurin-alpha-1 control of neuronal differentiation." Birmingham, Ala. : University of Alabama at Birmingham, 2010. https://www.mhsl.uab.edu/dt/2010m/hill.pdf.

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Thesis (M.S.)--University of Alabama at Birmingham, 2009.<br>Title from PDF t.p. (viewed June 30, 2010). Additional advisors: Lori McMahon, Stephen Watts. Includes bibliographical references (p. 31-35).

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3

Shi, Ri Yi. "Neuronal Survival After Dendrite Amputation: Investigation of Injury Current Blockage." Thesis, University of North Texas, 1988. https://digital.library.unt.edu/ark:/67531/metadc501278/.

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After dendrite transection, two primary injury current pathways may acount for cell death: (1) the lesion current at the site of injury and (2) the voltage sensitive calcium channels along the dendrite. Lesions were made with a laser microbeam in mouse spinal monolayer cell cultures. Polylysine was tried as a positively charged "molecular bandage" to block the lesion current. The calcium channel blockers, verapamil and nifedipine, were used to reduce the calcium channel current. Control toxicity curves were obtained for all three compounds. The results show that neither verapamil, nifedipine,

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4

Cruz, Daniel Sanzio Gimenes da. "Caracterização fenotípica e funcional de células dendríticas após vagotomia unilateral cervical em camundongos C57BL/6." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/10/10133/tde-07012014-083924/.

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O nervo vago exerce um papel importante na regulação da homeostase, e seus ramos eferentes emitem sinais capazes de atenuar a resposta inflamatória através da via do reflexo inflamatório. Nossa hipótese foi de que esta via pode também alterar a função das células dendríticas (DCs), uma vez que estas células possuem receptores colinérgicos e podem ser reguladas pelas citocinas inflamatórias. Sendo assim, DCs esplênicas e DCs geradas a partir de células precursoras da medula óssea de animais vagotomizados unilateralmente foram analisadas quanto aos marcadores fenotípicos CD11c e MHC-II e as molé

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5

Karam, Philippe Chucri. "Modeling passive and active mechanisms in motoneuron dendrites." Thesis, Georgia Institute of Technology, 2003. http://hdl.handle.net/1853/13713.

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6

Boucher, Jean-François. "L'effet des potentiels d'action rétropropagés sur la libération de neurotransmetteurs : comment les potentiels dendritiques augmentent le taux d'échec synaptique." Thesis, Université Laval, 2009. http://www.theses.ulaval.ca/2009/26974/26974.pdf.

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7

Oyebode, Oyinlola R. O. "Protection of neuromuscular sensory endings by the WldS gene." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4234.

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The compartmental hypothesis of neurodegeneration proposes that the neurone, long recognized to consist of morphologically and functionally distinct compartments, also houses distinct degeneration mechanisms for the soma, axon and nerve endings. Support for this hypothesis is provided by the phenomenon of the WldS (for Wallerian Degeneration, slow) mouse, a mutant in which axons survive several weeks after transection, rather than degenerating within 24-48 hours as in wild type mice, by virtue of expression of a chimeric Nmnat1/Ube4b protein. In this thesis I used the WldS-mouse to re-examine

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8

Chwalla, Barbara. "Genes and mechanisms underlying the development of dendrites in the central nervous system of the Drosophila embryo." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608389.

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9

Le, Roux Peter David. "Neuron-glial interactions in dendrite growth." Doctoral thesis, University of Cape Town, 1995. http://hdl.handle.net/11427/27039.

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Interactions between neurons and glia occupy a central role in many aspects of development, maintenance, and function of the central nervous system (CNS). A fundamental event in CNS development is the elaboration of two distinct neuronal processes, axons and dendrites. The overall aim of this research was to characterize the interactions between central nervous system neurons and astroglial cells that regulate dendrite growth from cerebral cortical neurons. Embryonic (E18) mouse cerebral cortical neurons were cocultured with early postnatal (P4) rat astroglia derived from cerebral cortex, reti

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10

Titus, Haley E. "Reorganization of Ia afferent synapses on motoneurons after peripheral nerve injuries." Wright State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=wright1245378110.

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11

Moore, Carlene Drucilla. "The role of centaurin alpha-1 in the regulation of neuronal differentiation." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008d/moore.pdf.

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12

Oppong, Francis. "Prenatal Alcohol Exposure Reduces Dendritic Spine Density across Sensory Cortices." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/2482.

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Dendritic spines are the major site of excitatory synapses in cortex, and factors that reduce dendritic spine numbers will produce serious cortical processing deficits, such as has been demonstrated for mental retardation and other psychiatric disorders. Prenatal alcohol exposure also has detrimental effects on brain development that lead to Fetal Alcohol Spectrum Disorder (FASD), which results in reduction of dendritic spine numbers in the hippocampus, prefrontal cortex and somatosensory cortex. FASD also is associated with temporal processing disorders involving sequential auditory stimuli t

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13

Deng, Qingwei 1968. "Identification of dendritic targeting signals of voltage-gated potassium channel 3." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=82219.

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Members of voltage-gated potassium channel subfamily 3 (Kv3) have been extensively demonstrated to play a significant role in facilitating function of "fast-firing" neurons in the central nervous system. Kv3.1 and Kv3.3 channels, members of Kv3 channel subfamily, have different distribution profiles on the regional level of brain and on the subcellular level of neurons in mammals and in weakly electric fish, according to mRNA hybridizations in situ and immunohistochemical analysis. In mammals, Kv3.1 channels are expressed in soma, axon and proximal dendrites as well as presynaptic membr

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14

Laporte, Marine. "Rôle de la protéine Alix dans le système nerveux central : De la neurogenèse à la plasticité synaptique." Thesis, Université Grenoble Alpes (ComUE), 2015. http://www.theses.fr/2015GREAV007/document.

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Alix (ALG-2 Interacting Protein X) est une protéine cytoplasmique impliquée dans divers processus cellulaires allant de l'apoptose à la cytocinèse en passant par le bourgeonnement des virus, la réparation membranaire et la régulation de la voie endosomale. Toutes ces fonctions sont étroitement associées à l'interaction d'Alix avec ses partenaires impliqués dans la déformation des membranes telles que les endophilines A, Tsg-101 et CHMP4B du complexe ESCRT (Endosomal Sorting Complex Required for Transport). Le but de ce projet est de caractériser le phénotype de la souris Alix ko récemment déve

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15

Horne, Eric Andrew. "Regulation of AKAP79/150 targeting to dendritic spines /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.

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Thesis (Ph.D. in Pharmacology) -- University of Colorado Denver, 2007.<br>Typescript. Includes bibliographical references (leaves 132-151). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

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16

Bajwa, Moazzum. "Dendritic Spine Density Varies Between Unisensory and Multisensory Cortical Regions." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/87.

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In the brain, the dendritic spine is a point of information exchange that extends the neuronal surface on which synapses occur, as well as facilitates and stabilizes those contacts. Furthermore, dendritic spines dynamically change in shape and number in response to a variety of factors. Dendritic spine numbers are reduced in mental retardation, enhanced during development, sensory enrichment or physical exercise, or fluctuate during the reproductive cycle. Thus, for a given neuron type, it might be expected that dendritic spine number might achieve a dynamic optimum. Indeed, many studies o

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17

Cruz, Daniel Sanzio Gimenes da. "Papel dos adrenoceptores β em células dendríticas derivadas de monócitos humanos." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/10/10133/tde-21062017-160938/.

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O sistema nervoso simpático (SNS) inerva a maioria dos órgãos linfoides e durante situações de estresse, por meio da liberação da noradrenalina de seus ramos eferentes, emitem sinais capazes de modular as repostas imunes. Nossa hipótese foi de que esta via poderia alterar a função de células dendríticas (DCs) derivadas de monócitos humanos, uma vez que receptores adrenérgicos já foram demonstrados em DCs murinas e pelo fato de que as estas células são chave na iniciação de respostas imunes adaptativas, bem como indutoras de tolerância. Desta forma, DCs diferenciadas a partir de monócitos sangu

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18

Rooney, Timothy M. "Genes Required for Wallerian Degeneration Also Govern Dendrite Degeneration: A Dissertation." eScholarship@UMMS, 2004. http://escholarship.umassmed.edu/gsbs_diss/775.

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Neurons comprise the main information processing cells of the nervous system. To integrate and transmit information, neurons elaborate dendritic structures to receive input and axons to relay that information to other cells. Due to their intricate structures, dendrites and axons are susceptible to damage whether by physical means or via disease mechanisms. Studying responses to axon injury, called Wallerian degeneration, in the neuronal processes of Drosophila melanogaster has allowed the identification of genes that are required for injury responses. Screens in Drosophila have identified dsar

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Rooney, Timothy M. "Genes Required for Wallerian Degeneration Also Govern Dendrite Degeneration: A Dissertation." eScholarship@UMMS, 2015. https://escholarship.umassmed.edu/gsbs_diss/775.

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Neurons comprise the main information processing cells of the nervous system. To integrate and transmit information, neurons elaborate dendritic structures to receive input and axons to relay that information to other cells. Due to their intricate structures, dendrites and axons are susceptible to damage whether by physical means or via disease mechanisms. Studying responses to axon injury, called Wallerian degeneration, in the neuronal processes of Drosophila melanogaster has allowed the identification of genes that are required for injury responses. Screens in Drosophila have identified dsar

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20

Pradhan, Anuradha. "Dissection of protein-protein interactions that regulate dendritic growth and synaptic transmission /." Oklahoma City : [s.n.], 2005.

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21

Cechim, Giovana. "Síntese de proteínas do sistema complemento por células dendríticas derivadas de monócitos na presença de sobrenadante tumoral." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-25052012-085656/.

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O processo de apresentação antigênica realizado pelas células dendríticas (DC) aos linfócitos T constitui o passo inicial da geração da resposta imune anti-tumoral. As neoplasias interferem nesse processo alterando funcionalmente as DCs. Entre os fatores que influenciam a função das DCs, está a proteína C3 do sistema complemento. Assim, este trabalho investigou a influência de fatores solúveis dos sobrenadantes tumorais das linhagens de glioblastoma humano A172 e U87MG sobre a síntese de C3 pelas DCs derivadas de doadores saudáveis in vitro. A fenotipagem indicou que os sobrenadantes, especial

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22

Roussignol, Gautier. "Un problème épineux : rôles fonctionnels de la protéine Shank dans la synaptogenèse et la morphogenèse des épines dendritiques." Montpellier 1, 2005. http://www.theses.fr/2005MON1T006.

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DANS LE SYSTEME NERVEUX CENTRAL DES MAMMIFERES, LES EPINES DENDRITIQUES SUPPORTENT LA MAJORITE DES SYNAPSES EXCITATRICES GLUTAMATERGIQUES. CHAQUE EPINE CONSTITUE UN COMPARTIMENT CELLULAIRE A PART ENTIERE CONTROLANT LE FONCTIONNEMENT DE LA SYNAPSE. PLUSIEURS MODELES DE GENESE DES EPINES DENDRITIQUES ONT ETE PROPOSES. AU NIVEAU DU CERVELET, L'APPARITION D'EPINES DENDRITIQUES DEPOURVUES DE CONTACT AXONAL SUR LES CELLULES DE PURKINJE SUGGERE L'EXISTENCE D'UN MECANISME INTRINSEQUE POST-SYNAPTIQUE D'INDUCTION DES EPINES DENDRITIQUES. AU NIVEAU DES SYNAPSES GLUTAMATERGIQUES, LES RECEPTEURS MEMBRANAIR

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23

Salomon, Steven. "Expression of the formin Daam 1 in pyramidal neurons of the hippocampus affects spine morphology." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=98789.

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Formins, also known as formin homology (FH) proteins, are involved in a wide range of actin-mediated processes. The Diaphanous-related formin Daam1 (Dishevelled-associated activator of morphogenesis) interacts with the PDZ domain protein Dishevelled, and is required to establish planar cell polarity in Xenopus. Through a yeast two-hybrid screen, I characterized a PDZ-mediated interaction between the C-terminus of Daam1 and the PDZ domains 456 of GRIP1. In dissociated rat hippocampal cultures, Daam1 expression was seen throughout the soma and dendrites in a punctate pattern. Furthermore, co-sta

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24

Bauer, Rachel J. "THE EFFECTS OF LONG-TERM DEAFNESS ON DENSITY AND DIAMETER OF DENDRITIC SPINES ON PYRAMIDAL NEURONS IN THE DORSAL ZONE OF THE FELINE AUDITORY CORTEX." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/6028.

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Neuroplasticity has been researched in many different ways, from the growing neonatal brain to neural responses to trauma and injury. According to recent research, neuroplasticity is also prevalent in the ability of the brain to repurpose areas that are not of use, like in the case of a loss of a sense. Specifically, behavioral studies have shown that deaf humans (Bavalier and Neville, 2002) and cats have increased visual ability, and that different areas of the auditory cortex enhance specific kinds of sight. One such behavioral test demonstrated that the dorsal zone (DZ) of the auditory cort

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25

Hamel, Michelle Grace. "Modulation of neural plasticity by the ADAMTSs (a disintegrin and metalloproteinase with thrombospondin motifs)." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001684.

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26

Romanets, Olga. "Study of the role of measles virus receptor CD150 in viral immunopathogenesis and characterization of novel CD150 isoform." Phd thesis, Ecole normale supérieure de lyon - ENS LYON, 2012. http://tel.archives-ouvertes.fr/tel-00923189.

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Measles virus (MV) causes an acute childhood disease, associated in certain cases with the infection of the central nervous system (CNS). MV induces a profound immunosuppression, resulting in high infant mortality. The major cellular receptor for MV is CD150, which binds MV hemagglutinin (MV-H). As dendritic cell (DC) dysfunction is considered to be essential for the MV immunopathogenesis, we analyzed consequences of MV-H interaction with DCs. We developed an experimental model allowing us to analyze the direct CD150-MV-H interaction in the absence of infectious context. This interaction cause

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27

Lajeunesse, Francis. "Modélisation de l'intégration des entrées synaptiques excitatrices chez les cellules thalamocorticales." Thesis, Université Laval, 2011. http://www.theses.ulaval.ca/2011/28114/28114.pdf.

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Les cellules thalamocorticales (TC) du noyau ventro-postéro-latéral (VPL) du thalamus relayent l'information du système somatosensoriel (synapses excitatrices lemniscales aux dendrites proximaux) à la région correspondante du cortex, mais reçoivent également en rétro-propagation des projections du cortex (synapses excitatrices corticothalamiques aux dendrites distaux). Afin d'étudier l'intégration synaptique aux différentes parties de la cellule TC, nous avons bâti un modèle multi-compartimental à partir de reconstructions tridimensionnelles de cellules du noyau VPL, ce qui consiste en une dis

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28

Yang, Shun-Jen. "The Molecular Mechanisms Underlying the Polarized Distribution of Drosophila Dscam in Neurons: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/390.

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Neurons exhibit highly polarized structures, including two morphologically and functionally distinct domains, axons and dendrites. Dendrites and axons receive versus send information, and proper execution of each requires different sets of molecules. Differential distribution of membrane proteins in distinct neuronal compartments plays essential roles in neuronal functions. The major goal of my doctoral thesis was to study the molecular mechanisms that govern the differential distribution of membrane proteins in neurons, using the Drosophilalarval mushroom body (MB) as a model system. My work

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29

Fernández, José R. "Structural characterization and transcriptional regulation of the cytosolic PSD-95 interacting protein (cypin) and its role in neuronal dendrite branching." 2008. http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17468.

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30

Boyle, Lia. "A Precision Medicine Approach to Understanding KIF1A Associated Neurological Disorder." Thesis, 2021. https://doi.org/10.7916/d8-0nef-s787.

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The functional compartmentalization underlying neuronal polarity makes tightly regulated intracellular transport between the cell body, axons, and dendrites essential for proper development and homeostatic maintenance. Disruptions to neuronal trafficking are a major cause of neurodegenerative disease. Pathogenic variants in the microtubule motor protein KIF1A cause KIF1A Associated Neurological Disorder (KAND), a spectrum of rare neurodegenerative conditions. KAND is clinically and genetically heterogeneous, with a broad phenotypic spectrum and over a hundred pathogenic variants identified. KA

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31

Agostinone, Jessica. "The role of insulin in retinal ganglion cell dendrite and synapse regeneration after optic nerve injury : molecular mechanisms and potential therapeutic targets." Thesis, 2019. http://hdl.handle.net/1866/23991.

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Le glaucome, comme beaucoup d’autres maladies neurodégénératives, entraîne la mort des neurones et reste à ce jour incurable, représentant de ce fait un véritable fardeau pour la société. Il y a donc un réel besoin de développer de nouvelles stratégies thérapeutiques afin de ralentir la progression, voire de guérir les maladies neurologiques. Depuis des décennies, les chercheurs qui étudient les blessures ainsi que les maladies qui affectent le système nerveux central (SNC) ont focalisé leur attention sur la compréhension des mécanismes impliqués dans la dégénérescence axonale afin d’identifie

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32

Cheung, Vincent W. "Biocompatible polymer coatings for implants in the peripheral nervous system : in vivo study of polymer-coated microbeads in the rat sciatic model." Thesis, 2020. http://hdl.handle.net/1866/25183.

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Introduction: Les implants dans le système nerveux périphérique (SNP) peuvent potentiellement restaurer les capacités sensorielles et motrices chez les patients avec des amputations des membres supérieures. Cependant, la réaction à un corps étrangers affecte significativement la fonction à long-terme et la biocompatibilité de ces systèmes avec le temps. Le dendrimère (DND) et la Poly-D-Lysine (PDL) sont deux polymères synthétiques qui peuvent potentiellement améliorer la performance de ces implants. Pour cette étude, notre objectif est de déterminer si ces polymères peuvent promouvoir la forma

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33

Terouz, Simone. "Ninjurin-1 est une molécule d'adhérence de la barrière hémato-encéphalique impliquée dans le recrutement de monocytes au sein du système nerveux central." Thèse, 2010. http://hdl.handle.net/1866/4655.

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La sclérose en plaques (SEP) est caractérisée par des infiltrations périvasculaires de cellules immunitaires et par de la démyélinisation au sein du système nerveux central (SNC). Ces deux paramètres de la maladie sont associés à la fragilisation de la barrière hémato-encéphalique (BHE). En ce sens, le recrutement des cellules présentatrices d’antigène (CPA) myéloïdes, telles que les monocytes, les macrophages et les cellules dendritiques, dans le SNC à travers la BHE, est une étape cruciale dans l’initiation et la persistance de l’inflammation cérébrale. Nerve injury-induced protein (Ninjurin

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34

McMorland, Angus John Cathcart. "Shining new light on motoneurons: characterization of motoneuron dendritic spines using light microscopy and novel analytical methods." 2009. http://hdl.handle.net/2292/4268.

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Dendritic spines are fundamental units of information processing within the nervous system, responsible for independent modulation of synaptic input to neurons. Filopodia, often morphologically indistinguishable from spines, are involved in formation of synapses during neuronal development. Despite the importance of these structures for neuronal function, no detailed study of their presence on motoneurons has yet been made. Here, the presence of spines on hypoglossal motoneurons (HMs) is described at three developmental stages: at P0–2 and P9–11, spines are present at an average density of ~0.

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35

Ifergan, Igal. "Modulation de la réponse immunitaire dans le cerveau par la barrière hémato-encéphalique : implication en sclérose en plaques." Thèse, 2011. http://hdl.handle.net/1866/7042.

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La sclérose en plaques (SEP) est une maladie inflammatoire du système nerveux central (SNC) caractérisée par une infiltration périvasculaire de cellules mononucléaires, telles que les lymphocytes T CD4+ et CD8+, les lymphocytes B ainsi que les cellules myéloïdes qui comprend les monocytes, les macrophages et les cellules dendritiques (DCs). Ce phénomène d’infiltration est dû à une fragilisation de la barrière hémato-encéphalique (BHE). L’entrée des cellules immunitaires au SNC va mener à la destruction de la gaine de myéline et donc à l’apparition de plaques de démyélinisation. Ainsi, nous avo

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Corrêa, Sonia A. L., C. J. Hunter, O. Palygin, et al. "MSK1 regulates homeostatic and experience-dependent synaptic plasticity." 2012. http://hdl.handle.net/10454/5942.

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No<br>The ability of neurons to modulate synaptic strength underpins synaptic plasticity, learning and memory, and adaptation to sensory experience. Despite the importance of synaptic adaptation in directing, reinforcing, and revising the behavioral response to environmental influences, the cellular and molecular mechanisms underlying synaptic adaptation are far from clear. Brain-derived neurotrophic factor (BDNF) is a prime initiator of structural and functional synaptic adaptation. However, the signaling cascade activated by BDNF to initiate these adaptive changes has not been elucidated. We

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