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1
O'Shea, M. "Introduction to neuropeptides: perspectives for the parasitologist." Parasitology 102, S1 (1991): S71—S75. http://dx.doi.org/10.1017/s0031182000073303.
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At the cellular and molecular levels, the small and simpler nervous systems of invertebrates do not differ fundamentally from the larger more complex ones of vertebrates. It seems therefore that the special properties of the human brain arise more from the fact that it has ten trillion cellular components than from any unusual properties of the components themselves. By studying invertebrates we can gain insight into what basic functions are performed by the cells and molecules of the nervous system and this will contribute to a more fundamental understanding of what goes on in a system in which the same functions are performed by uncountable numbers of neurones. Invertebrate studies are also important for an entirely different reason; they are interesting and important in their own right. Moreover, a relatively small number of invertebrates are pests; either parasites, vectors of serious parasitic diseases or pests of our agricultural production. It is no accident that most of the methods that are used to control such organisms act on their nervous system. That is because the nervous system is a complex chemical machine which works through a great variety of chemical interactions between a wide diversity of receptors and ligands. Many currently used control methods work because they disrupt these interactions. For this reason I would imagine that the new generation of compounds developed to control invertebrates will depend for their activity on interactions with the nervous system. Since most of the chemical effectors (transmitters, modulators and hormones) in the nervous system are peptides, a number of these newly developed approaches will depend upon a fundamental knowledge of peptidergic systems in parasites. This essay is about peptidergic systems and indicates how we might exploit their vulner-ability to interference.
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Deidda, Irene, Roberta Russo, Rosa Bonaventura, Caterina Costa, Francesca Zito, and Nadia Lampiasi. "Neurotoxicity in Marine Invertebrates: An Update." Biology 10, no. 2 (2021): 161. http://dx.doi.org/10.3390/biology10020161.
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Invertebrates represent about 95% of existing species, and most of them belong to aquatic ecosystems. Marine invertebrates are found at intermediate levels of the food chain and, therefore, they play a central role in the biodiversity of ecosystems. Furthermore, these organisms have a short life cycle, easy laboratory manipulation, and high sensitivity to marine pollution and, therefore, they are considered to be optimal bioindicators for assessing detrimental chemical agents that are related to the marine environment and with potential toxicity to human health, including neurotoxicity. In general, albeit simple, the nervous system of marine invertebrates is composed of neuronal and glial cells, and it exhibits biochemical and functional similarities with the vertebrate nervous system, including humans. In recent decades, new genetic and transcriptomic technologies have made the identification of many neural genes and transcription factors homologous to those in humans possible. Neuroinflammation, oxidative stress, and altered levels of neurotransmitters are some of the aspects of neurotoxic effects that can also occur in marine invertebrate organisms. The purpose of this review is to provide an overview of major marine pollutants, such as heavy metals, pesticides, and micro and nano-plastics, with a focus on their neurotoxic effects in marine invertebrate organisms. This review could be a stimulus to bio-research towards the use of invertebrate model systems other than traditional, ethically questionable, time-consuming, and highly expensive mammalian models.
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Bittner, G. "Zoophysiology: Nervous System Regeneration in the Invertebrates." Trends in Neurosciences 20, no. 1 (1997): 49. http://dx.doi.org/10.1016/s0166-2236(96)60039-3.
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van Haeften, Theo, and Floris G. Wouterlood. "Methods for studying the nervous system of invertebrates." Journal of Neuroscience Methods 69, no. 1 (1996): 1. http://dx.doi.org/10.1016/s0165-0270(96)00015-5.
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Juricek, Ludmila, and Xavier Coumoul. "The Aryl Hydrocarbon Receptor and the Nervous System." International Journal of Molecular Sciences 19, no. 9 (2018): 2504. http://dx.doi.org/10.3390/ijms19092504.
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The aryl hydrocarbon receptor (or AhR) is a cytoplasmic receptor of pollutants. It translocates into the nucleus upon binding to its ligands, and forms a heterodimer with ARNT (AhR nuclear translocator). The heterodimer is a transcription factor, which regulates the transcription of xenobiotic metabolizing enzymes. Expressed in many cells in vertebrates, it is mostly present in neuronal cell types in invertebrates, where it regulates dendritic morphology or feeding behavior. Surprisingly, few investigations have been conducted to unravel the function of the AhR in the central or peripheral nervous systems of vertebrates. In this review, we will present how the AhR regulates neural functions in both invertebrates and vertebrates as deduced mainly from the effects of xenobiotics. We will introduce some of the molecular mechanisms triggered by the well-known AhR ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which impact on neuronal proliferation, differentiation, and survival. Finally, we will point out the common features found in mice that are exposed to pollutants, and in AhR knockout mice.
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Singh, Rajani. "Is the Tubular Nervous System Related with the Development of Skeletal Muscle in Chordates? – A Review." Journal of Morphological Sciences 35, no. 04 (2018): 207–11. http://dx.doi.org/10.1055/s-0038-1675617.
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AbstractMany theories and arguments have been proposed regarding the ancestors of the vertebrates and the factors that lead to the evolution of the tubular nervous system. Invertebrates had simpler smooth muscles. Vertebrates acquired additional skeletal muscles. The skeletal muscles were found to be associated with a new type of tubular nervous system. There were three stages in the evolution of the nervous system. The most primitive was the network type, in which there was neither a polarization nor a centralization of neurons. The second stage was characterized by the evolution of a ganglionic nervous system. Then, the tubular type of nervous system appeared for the first time in chordates. Therefore, the author hypothesizes that the skeletal muscle developed simultaneously with the tubular nervous system. The chorda mesoderm and, thereby, the skeletal muscle, induced the formation of a tubular nervous system in chordates. In the present article, the author aims to analyze the nervous system, starting from invertebrates and moving on to chordates.
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Frasnelli, Elisa, Giorgio Vallortigara, and Lesley J. Rogers. "Left–right asymmetries of behaviour and nervous system in invertebrates." Neuroscience & Biobehavioral Reviews 36, no. 4 (2012): 1273–91. http://dx.doi.org/10.1016/j.neubiorev.2012.02.006.
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RIDGWAY, RICHARD L., and STACIA B. MOFFETT. "Introduction to the Symposium: Nervous System Regeneration in the Invertebrates." American Zoologist 28, no. 4 (1988): 1051–52. http://dx.doi.org/10.1093/icb/28.4.1051.
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Burrell, Brian D. "Comparative biology of pain: What invertebrates can tell us about how nociception works." Journal of Neurophysiology 117, no. 4 (2017): 1461–73. http://dx.doi.org/10.1152/jn.00600.2016.
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The inability to adequately treat chronic pain is a worldwide health care crisis. Pain has both an emotional and a sensory component, and this latter component, nociception, refers specifically to the detection of damaging or potentially damaging stimuli. Nociception represents a critical interaction between an animal and its environment and exhibits considerable evolutionary conservation across species. Using comparative approaches to understand the basic biology of nociception could promote the development of novel therapeutic strategies to treat pain, and studies of nociception in invertebrates can provide especially useful insights toward this goal. Both vertebrates and invertebrates exhibit segregated sensory pathways for nociceptive and nonnociceptive information, injury-induced sensitization to nociceptive and nonnociceptive stimuli, and even similar antinociceptive modulatory processes. In a number of invertebrate species, the central nervous system is understood in considerable detail, and it is often possible to record from and/or manipulate single identifiable neurons through either molecular genetic or physiological approaches. Invertebrates also provide an opportunity to study nociception in an ethologically relevant context that can provide novel insights into the nature of how injury-inducing stimuli produce persistent changes in behavior. Despite these advantages, invertebrates have been underutilized in nociception research. In this review, findings from invertebrate nociception studies are summarized, and proposals for how research using invertebrates can address questions about the fundamental mechanisms of nociception are presented.
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Arendt, Detlev, Alexandru S. Denes, Gáspár Jékely, and Kristin Tessmar-Raible. "The evolution of nervous system centralization." Philosophical Transactions of the Royal Society B: Biological Sciences 363, no. 1496 (2008): 1523–28. http://dx.doi.org/10.1098/rstb.2007.2242.
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It is yet unknown when and in what form the central nervous system in Bilateria first came into place and how it further evolved in the different bilaterian phyla. To find out, a series of recent molecular studies have compared neurodevelopment in slow-evolving deuterostome and protostome invertebrates, such as the enteropneust hemichordate Saccoglossus and the polychaete annelid Platynereis . These studies focus on the spatially different activation and, when accessible, function of genes that set up the molecular anatomy of the neuroectoderm and specify neuron types that emerge from distinct molecular coordinates. Complex similarities are detected, which reveal aspects of neurodevelopment that most likely occurred already in a similar manner in the last common ancestor of the bilaterians, Urbilateria. This way, different aspects of the molecular architecture of the urbilaterian nervous system are reconstructed and yield insight into the degree of centralization that was in place in the bilaterian ancestors.
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Kasuya, Y., H. Kobayashi, and H. Uemura. "Endothelin-Like Immunoreactivity in the Nervous System of Invertebrates and Fish." Journal of Cardiovascular Pharmacology 17 (1991): S463–466. http://dx.doi.org/10.1097/00005344-199100177-00133.
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Spong, Kristin E., R. David Andrew, and R. Meldrum Robertson. "Mechanisms of spreading depolarization in vertebrate and insect central nervous systems." Journal of Neurophysiology 116, no. 3 (2016): 1117–27. http://dx.doi.org/10.1152/jn.00352.2016.
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Spreading depolarization (SD) is generated in the central nervous systems of both vertebrates and invertebrates. SD manifests as a propagating wave of electrical depression caused by a massive redistribution of ions. Mammalian SD underlies a continuum of human pathologies from migraine to stroke damage, whereas insect SD is associated with environmental stress-induced neural shutdown. The general cellular mechanisms underlying SD seem to be evolutionarily conserved throughout the animal kingdom. In particular, SD in the central nervous system of Locusta migratoria and Drosophila melanogaster has all the hallmarks of mammalian SD. Locust SD is easily induced and monitored within the metathoracic ganglion (MTG) and can be modulated both pharmacologically and by preconditioning treatments. The finding that the fly brain supports repetitive waves of SD is relatively recent but noteworthy, since it provides a genetically tractable model system. Due to the human suffering caused by SD manifestations, elucidating control mechanisms that could ultimately attenuate brain susceptibility is essential. Here we review mechanisms of SD focusing on the similarities between mammalian and insect systems. Additionally we discuss advantages of using invertebrate model systems and propose insect SD as a valuable model for providing new insights to mammalian SD.
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Hartenstein, Volker. "The neuroendocrine system of invertebrates: a developmental and evolutionary perspective." Journal of Endocrinology 190, no. 3 (2006): 555–70. http://dx.doi.org/10.1677/joe.1.06964.
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Neuroendocrine control mechanisms are observed in all animals that possess a nervous system. Recent analyses of neuroendocrine functions in invertebrate model systems reveal a great degree of similarity between phyla as far apart as nematodes, arthropods, and chordates. Developmental studies that emphasize the comparison between different animal groups will help to shed light on questions regarding the evolutionary origin and possible homologies between neuroendocrine systems. This review intends to provide a brief overview of invertebrate neuroendocrine systems and to discuss aspects of their development that appear to be conserved between insects and vertebrates.
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Holland, Nicholas D. "Nervous systems and scenarios for the invertebrate-to-vertebrate transition." Philosophical Transactions of the Royal Society B: Biological Sciences 371, no. 1685 (2016): 20150047. http://dx.doi.org/10.1098/rstb.2015.0047.
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Older evolutionary scenarios for the origin of vertebrates often gave nervous systems top billing in accordance with the notion that a big-brained Homo sapiens crowned a tree of life shaped mainly by progressive evolution. Now, however, tree thinking positions all extant organisms equidistant from the tree's root, and molecular phylogenies indicate that regressive evolution is more common than previously suspected. Even so, contemporary theories of vertebrate origin still focus on the nervous system because of its functional importance, its richness in characters for comparative biology, and its central position in the two currently prominent scenarios for the invertebrate-to-vertebrate transition, which grew out of the markedly neurocentric annelid and enteropneust theories of the nineteenth century. Both these scenarios compare phyla with diverse overall body plans. This diversity, exacerbated by the scarcity of relevant fossil data, makes it challenging to establish plausible homologies between component parts (e.g. nervous system regions). In addition, our current understanding of the relation between genotype and phenotype is too preliminary to permit us to convert gene network data into structural features in any simple way. These issues are discussed here with special reference to the evolution of nervous systems during proposed transitions from invertebrates to vertebrates.
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Rothwell, Cailin M., Eric de Hoog, and Gaynor E. Spencer. "The role of retinoic acid in the formation and modulation of invertebrate central synapses." Journal of Neurophysiology 117, no. 2 (2017): 692–704. http://dx.doi.org/10.1152/jn.00737.2016.
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Trophic factors can influence many aspects of nervous system function, such as neurite outgrowth, synapse formation, and synapse modulation. The vitamin A metabolite, retinoic acid, can exert trophic effects to promote neuronal survival and outgrowth in many species and is also known to modulate vertebrate hippocampal synapses. However, its role in synaptogenesis has not been well studied, and whether it can modulate existing invertebrate synapses is also not known. In this study, we first examined a potential trophic effect of retinoic acid on the formation of excitatory synapses, independently of its role in neurite outgrowth, using cultured neurons of the mollusc Lymnaea stagnalis. We also investigated its role in modulating both chemical and electrical synapses between various Lymnaea neurons in cell culture. Although we found no evidence to suggest retinoic acid affected short-term synaptic plasticity in the form of post-tetanic potentiation, we did find a significant cell type-specific modulation of electrical synapses. Given the prevalence of electrical synapses in invertebrate nervous systems, these findings highlight the potential for retinoic acid to modulate network function in the central nervous system of at least some invertebrates. NEW & NOTEWORTHY This study performed the first electrophysiological analysis of the ability of the vitamin A metabolite, retinoic acid, to exert trophic influences during synaptogenesis independently of its effects in supporting neurite outgrowth. It was also the first study to examine the ability of retinoic acid to modify both chemical and electrical synapses in any invertebrate, nonchordate species. We provide evidence that all-trans retinoic acid can modify invertebrate electrical synapses of central neurons in a cell-specific manner.
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Lacbawan, Felicitas L., and Maximilian Muenke. "Central Nervous System Embryogenesis and Its Failures." Pediatric and Developmental Pathology 5, no. 5 (2002): 425–47. http://dx.doi.org/10.1007/s10024-002-0003-3.
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The well-orchestrated development of the central nervous system (CNS) requires highly integrated regulatory processes to ensure its precise spatial organization that provides the foundation for proper function. As emphasized in this review, the type, timing, and location of regulatory molecules influence the different stages of development from neuronal induction, regional specification, neuronal specification, and neuronal migration to axonal growth and guidance, neuronal survival, and synapse formation. The known molecular mechanisms are summarized from studies of invertebrates and lower vertebrates, in which we have learned more about the different ligands, receptors, transcription factors, and the intracellular signaling pathways that play specific roles in the different stages of development. Despite known molecular mechanisms of some disturbances, most of the clinical entities that arise from failures of CNS embryogenesis remain unexplained. As more novel genes and their functions are discovered, existing mechanisms will be refined and tenable explanations will be made. With these limitations, two specific clinical entities that have been relatively well studied, holoprosen-cephaly and neuronal migration defects, are discussed in more detail to illustrate the complexity of regulatory mechanisms that govern well-defined stages of CNS development.
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Marinković, Milena, Jürgen Berger, and Gáspár Jékely. "Neuronal coordination of motile cilia in locomotion and feeding." Philosophical Transactions of the Royal Society B: Biological Sciences 375, no. 1792 (2019): 20190165. http://dx.doi.org/10.1098/rstb.2019.0165.
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Efficient ciliary locomotion and transport require the coordination of motile cilia. Short-range coordination of ciliary beats can occur by biophysical mechanisms. Long-range coordination across large or disjointed ciliated fields often requires nervous system control and innervation of ciliated cells by ciliomotor neurons. The neuronal control of cilia is best understood in invertebrate ciliated microswimmers, but similar mechanisms may operate in the vertebrate body. Here, we review how the study of aquatic invertebrates contributed to our understanding of the neuronal control of cilia. We summarize the anatomy of ciliomotor systems and the physiological mechanisms that can alter ciliary activity. We also discuss the most well-characterized ciliomotor system, that of the larval annelid Platynereis . Here, pacemaker neurons drive the rhythmic activation of cholinergic and serotonergic ciliomotor neurons to induce ciliary arrests and beating. The Platynereis ciliomotor neurons form a distinct part of the larval nervous system. Similar ciliomotor systems likely operate in other ciliated larvae, such as mollusc veligers. We discuss the possible ancestry and conservation of ciliomotor circuits and highlight how comparative experimental approaches could contribute to a better understanding of the evolution and function of ciliary systems. This article is part of the Theo Murphy meeting issue ‘Unity and diversity of cilia in locomotion and transport’.
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Fujii, Ken, and Naokuni Takeda. "Phylogenetic detection of serotonin immunoreactive cells in the central nervous system of invertebrates." Comparative Biochemistry and Physiology Part C: Comparative Pharmacology 89, no. 2 (1988): 233–39. http://dx.doi.org/10.1016/0742-8413(88)90217-4.
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Chittka, L., and P. Skorupski. "Information processing in miniature brains." Proceedings of the Royal Society B: Biological Sciences 278, no. 1707 (2011): 885–88. http://dx.doi.org/10.1098/rspb.2010.2699.
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Since a comprehensive understanding of brain function and evolution in vertebrates is often hobbled by the sheer size of the nervous system, as well as ethical concerns, major research efforts have been made to understand the neural circuitry underpinning behaviour and cognition in invertebrates, and its costs and benefits under natural conditions. This special feature of Proceedings of the Royal Society B contains an idiosyncratic range of current research perspectives on neural underpinnings and adaptive benefits (and costs) of such diverse phenomena as spatial memory, colour vision, attention, spontaneous behaviour initiation, memory dynamics, relational rule learning and sleep, in a range of animals from marine invertebrates with exquisitely simple nervous systems to social insects forming societies with many thousands of individuals working together as a ‘superorganism’. This introduction provides context and history to tie the various approaches together, and concludes that there is an urgent need to understand the full neuron-to-neuron circuitry underlying various forms of information processing—not just to explore brain function comprehensively, but also to understand how (and how easily) cognitive capacities might evolve in the face of pertinent selection pressures. In the invertebrates, reaching these goals is becoming increasingly realistic.
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Giachello, Carlo Natale Giuseppe, Pier Giorgio Montarolo, and Mirella Ghirardi. "Synaptic Functions of Invertebrate Varicosities: What Molecular Mechanisms Lie Beneath." Neural Plasticity 2012 (2012): 1–14. http://dx.doi.org/10.1155/2012/670821.
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In mammalian brain, the cellular and molecular events occurring in both synapse formation and plasticity are difficult to study due to the large number of factors involved in these processes and because the contribution of each component is not well defined. Invertebrates, such asDrosophila, Aplysia, Helix, Lymnaea,andHelisoma, have proven to be useful models for studying synaptic assembly and elementary forms of learning. Simple nervous system, cellular accessibility, and genetic simplicity are some examples of the invertebrate advantages that allowed to improve our knowledge about evolutionary neuronal conserved mechanisms. In this paper, we present an overview of progresses that elucidates cellular and molecular mechanisms underlying synaptogenesis and synapse plasticity in invertebrate varicosities and their validation in vertebrates. In particular, the role of invertebrate synapsin in the formation of presynaptic terminals and the cell-to-cell interactions that induce specific structural and functional changes in their respective targets will be analyzed.
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Jin, Eugene Jennifer, Seungmee Park, Xiaohui Lyu, and Yishi Jin. "Gap junctions: historical discoveries and new findings in the Caenorhabditiselegans nervous system." Biology Open 9, no. 8 (2020): bio053983. http://dx.doi.org/10.1242/bio.053983.
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ABSTRACTGap junctions are evolutionarily conserved structures at close membrane contacts between two cells. In the nervous system, they mediate rapid, often bi-directional, transmission of signals through channels called innexins in invertebrates and connexins in vertebrates. Connectomic studies from Caenorhabditis elegans have uncovered a vast number of gap junctions present in the nervous system and non-neuronal tissues. The genome also has 25 innexin genes that are expressed in spatial and temporal dynamic pattern. Recent findings have begun to reveal novel roles of innexins in the regulation of multiple processes during formation and function of neural circuits both in normal conditions and under stress. Here, we highlight the diverse roles of gap junctions and innexins in the C. elegans nervous system. These findings contribute to fundamental understanding of gap junctions in all animals.
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Bacqué-Cazenave, Julien, Rahul Bharatiya, Grégory Barrière, et al. "Serotonin in Animal Cognition and Behavior." International Journal of Molecular Sciences 21, no. 5 (2020): 1649. http://dx.doi.org/10.3390/ijms21051649.
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Serotonin (5-hydroxytryptamine, 5-HT) is acknowledged as a major neuromodulator of nervous systems in both invertebrates and vertebrates. It has been proposed for several decades that it impacts animal cognition and behavior. In spite of a completely distinct organization of the 5-HT systems across the animal kingdom, several lines of evidence suggest that the influences of 5-HT on behavior and cognition are evolutionary conserved. In this review, we have selected some behaviors classically evoked when addressing the roles of 5-HT on nervous system functions. In particular, we focus on the motor activity, arousal, sleep and circadian rhythm, feeding, social interactions and aggressiveness, anxiety, mood, learning and memory, or impulsive/compulsive dimension and behavioral flexibility. The roles of 5-HT, illustrated in both invertebrates and vertebrates, show that it is more able to potentiate or mitigate the neuronal responses necessary for the fine-tuning of most behaviors, rather than to trigger or halt a specific behavior. 5-HT is, therefore, the prototypical neuromodulator fundamentally involved in the adaptation of all organisms across the animal kingdom.
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Li, Yongbin, Di Zhao, Takeo Horie, et al. "Conserved gene regulatory module specifies lateral neural borders across bilaterians." Proceedings of the National Academy of Sciences 114, no. 31 (2017): E6352—E6360. http://dx.doi.org/10.1073/pnas.1704194114.
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The lateral neural plate border (NPB), the neural part of the vertebrate neural border, is composed of central nervous system (CNS) progenitors and peripheral nervous system (PNS) progenitors. In invertebrates, PNS progenitors are also juxtaposed to the lateral boundary of the CNS. Whether there are conserved molecular mechanisms determining vertebrate and invertebrate lateral neural borders remains unclear. Using single-cell-resolution gene-expression profiling and genetic analysis, we present evidence that orthologs of the NPB specification module specify the invertebrate lateral neural border, which is composed of CNS and PNS progenitors. First, like in vertebrates, the conserved neuroectoderm lateral border specifier Msx/vab-15 specifies lateral neuroblasts in Caenorhabditis elegans. Second, orthologs of the vertebrate NPB specification module (Msx/vab-15, Pax3/7/pax-3, and Zic/ref-2) are significantly enriched in worm lateral neuroblasts. In addition, like in other bilaterians, the expression domain of Msx/vab-15 is more lateral than those of Pax3/7/pax-3 and Zic/ref-2 in C. elegans. Third, we show that Msx/vab-15 regulates the development of mechanosensory neurons derived from lateral neural progenitors in multiple invertebrate species, including C. elegans, Drosophila melanogaster, and Ciona intestinalis. We also identify a novel lateral neural border specifier, ZNF703/tlp-1, which functions synergistically with Msx/vab-15 in both C. elegans and Xenopus laevis. These data suggest a common origin of the molecular mechanism specifying lateral neural borders across bilaterians.
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Moroz, L. L., R. Gillette, and J. V. Sweedler. "Single-cell analyses of nitrergic neurons in simple nervous systems." Journal of Experimental Biology 202, no. 4 (1999): 333–41. http://dx.doi.org/10.1242/jeb.202.4.333.
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Understanding the role of the gaseous messenger nitric oxide (NO) in the nervous system is complicated by the heterogeneity of its nerve cells; analyses carried out at the single cell level are therefore important, if not critical. Some invertebrate preparations, most especially those from the gastropod molluscs, provide large, hardy and identified neurons that are useful both for the development of analytical methodologies and for cellular analyses of NO metabolism and its actions. Recent modifications of capillary electrophoresis (CE) allow the use of a small fraction of an individual neuron to perform direct, quantitative and simultaneous assays of the major metabolites of the NO-citrulline cycle and associated biochemical pathways. These chemical species include the products of NO oxidation (NO2-/NO3-), l-arginine, l-citrulline, l-ornithine, l-argininosuccinate, as well as selected NO synthase inhibitors and cofactors such as NADPH, biopterin, FMN and FAD. Diverse cotransmitters can also be identified in the same nitrergic neuron. The sensitivity of CE methods is in the femtomole to attomole range, depending on the species analysed and on the specific detector used. CE analysis can be combined with prior in vivo electrophysiological and pharmacological manipulations and measurements to yield multiple physiological and biochemical values from single cells. The methodologies and instrumentation developed and tested using the convenient molluscan cell model can be adapted to the smaller and more delicate neurons of other invertebrates and chordates.
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Katz, Paul S. "Neural mechanisms underlying the evolvability of behaviour." Philosophical Transactions of the Royal Society B: Biological Sciences 366, no. 1574 (2011): 2086–99. http://dx.doi.org/10.1098/rstb.2010.0336.
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The complexity of nervous systems alters the evolvability of behaviour. Complex nervous systems are phylogenetically constrained; nevertheless particular species-specific behaviours have repeatedly evolved, suggesting a predisposition towards those behaviours. Independently evolved behaviours in animals that share a common neural architecture are generally produced by homologous neural structures, homologous neural pathways and even in the case of some invertebrates, homologous identified neurons. Such parallel evolution has been documented in the chromatic sensitivity of visual systems, motor behaviours and complex social behaviours such as pair-bonding. The appearance of homoplasious behaviours produced by homologous neural substrates suggests that there might be features of these nervous systems that favoured the repeated evolution of particular behaviours. Neuromodulation may be one such feature because it allows anatomically defined neural circuitry to be re-purposed. The developmental, genetic and physiological mechanisms that contribute to nervous system complexity may also bias the evolution of behaviour, thereby affecting the evolvability of species-specific behaviour.
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Newland, N. L., P. J. S. Smith, and E. A. Howes. "REGENERATING ADULT COCKROACH DORSAL UNPAIRED MEDIAN NEURONES IN VITRO RETAIN THEIR IN VIVO MEMBRANE CHARACTERISTICS." Journal of Experimental Biology 179, no. 1 (1993): 323–29. http://dx.doi.org/10.1242/jeb.179.1.323.
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The ability of differentiated neurones to recover from disease or injury depends upon both intrinsic and extrinsic factors. Whereas most mammalian neurones have a limited capacity for regeneration, regulated, in part, by physical and chemical cues in the brain microenvironment (Bray et al. 1987; Caroni and Schwab, 1988, 1989), invertebrates, and in particular insects, exhibit a far greater capacity for repair of central neurones and circuits (Treherne et al. 1988). Studies of the cues that regulate the regenerative process are made easier by the use of individual, identified neurones, cultured under controlled conditions. Invertebrates are particularly useful in this regard; neurones from mature nervous systems of both annelids and molluscs have been grown successfully in culture and their growth can be influenced by changes in the culture conditions (Acklin and Nicholls, 1990; Dagan and Levitan, 1981; Ready and Nicholls, 1979; Syed et al. 1990). Routine and long-term culture of identified neurones from the insect central nervous system (CNS) has proved more elusive, preventing the use of neurones from these well-studied systems. Recently, however, cultures of cockroach (Howes et al. 1991), locust (Kirchoff and Bicker, 1992) and moth (Hayashi and Levine, 1992) adult neurones have been described.
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Sower, Stacia A., Kunimasa Suzuki, and Karen L. Reed. "Perspective: Research Activity of Enteropancreatic and Brain/Central Nervous System Hormones Across Invertebrates and Vertebrates1." American Zoologist 40, no. 2 (2000): 165–78. http://dx.doi.org/10.1668/0003-1569(2000)040[0165:praoea]2.0.co;2.
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Sower, Stacia A., Kunimasa Suzuki, and Karen L. Reed. "Perspective: Research Activity of Enteropancreatic and Brain/Central Nervous System Hormones Across Invertebrates and Vertebrates." American Zoologist 40, no. 2 (2000): 165–78. http://dx.doi.org/10.1093/icb/40.2.165.
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Montanari, Martina, and Julien Royet. "Impact of Microorganisms and Parasites on Neuronally Controlled Drosophila Behaviours." Cells 10, no. 9 (2021): 2350. http://dx.doi.org/10.3390/cells10092350.
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Like all invertebrates, flies such as Drosophila lack an adaptive immune system and depend on their innate immune system to protect them against pathogenic microorganisms and parasites. In recent years, it appears that the nervous systems of eucaryotes not only control animal behavior but also cooperate and synergize very strongly with the animals’ immune systems to detect and fight potential pathogenic threats, and allow them to adapt their behavior to the presence of microorganisms and parasites that coexist with them. This review puts into perspective the latest progress made using the Drosophila model system, in this field of research, which remains in its infancy.
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Kawada, Tsuyoshi, Michio Ogasawara, Toshio Sekiguchi, et al. "Peptidomic Analysis of the Central Nervous System of the Protochordate, Ciona intestinalis: Homologs and Prototypes of Vertebrate Peptides and Novel Peptides." Endocrinology 152, no. 6 (2011): 2416–27. http://dx.doi.org/10.1210/en.2010-1348.
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The phylogenetic position of ascidians as the chordate invertebrates closest to vertebrates suggests that they might possess homologs and/or prototypes of vertebrate peptide hormones and neuropeptides as well as ascidian-specific peptides. However, only a small number of peptides have so far been identified in ascidians. In the present study, we have identified various peptides in the ascidian, Ciona intestinalis. Mass spectrometry-based peptidomic analysis detected 33 peptides, including 26 novel peptides, from C. intestinalis. The ascidian peptides are largely classified into three categories: 1) prototypes and homologs of vertebrate peptides, such as galanin/galanin-like peptide, which have never been identified in any invertebrates; 2) peptides partially homologous with vertebrate peptides, including novel neurotesin-like peptides; 3) novel peptides. These results not only provide evidence that C. intestinalis possesses various homologs and prototypes of vertebrate neuropeptides and peptide hormones but also suggest that several of these peptides might have diverged in the ascidian-specific evolutionary lineage. All Ciona peptide genes were expressed in the neural complex, whereas several peptide gene transcripts were also distributed in peripheral tissues, including the ovary. Furthermore, a Ciona neurotensin-like peptide, C. intestinalis neurotensin-like peptide 6, was shown to down-regulate growth of Ciona vitellogenic oocytes. These results suggest that the Ciona peptides act not only as neuropeptides in the neural tissue but also as hormones in nonneuronal tissues and that ascidians, unlike other invertebrates, such as nematodes, insects, and sea urchins, established an evolutionary origin of the peptidergic neuroendocrine, endocrine, and nervous systems of vertebrates with certain specific molecular diversity.
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Ramirez, Jan-Marino, and Nathan Baertsch. "Defining the Rhythmogenic Elements of Mammalian Breathing." Physiology 33, no. 5 (2018): 302–16. http://dx.doi.org/10.1152/physiol.00025.2018.
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Breathing’s remarkable ability to adapt to changes in metabolic, environmental, and behavioral demands stems from a complex integration of its rhythm-generating network within the wider nervous system. Yet, this integration complicates identification of its specific rhythmogenic elements. Based on principles learned from smaller rhythmic networks of invertebrates, we define criteria that identify rhythmogenic elements of the mammalian breathing network and discuss how they interact to produce robust, dynamic breathing.
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Coppola, Ugo, Paola Olivo, Enrico D’Aniello, Christopher J. Johnson, Alberto Stolfi, and Filomena Ristoratore. "Rimbp, a New Marker for the Nervous System of the Tunicate Ciona robusta." Genes 11, no. 9 (2020): 1006. http://dx.doi.org/10.3390/genes11091006.
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Establishment of presynaptic mechanisms by proteins that regulate neurotransmitter release in the presynaptic active zone is considered a fundamental step in animal evolution. Rab3 interacting molecule-binding proteins (Rimbps) are crucial components of the presynaptic active zone and key players in calcium homeostasis. Although Rimbp involvement in these dynamics has been described in distantly related models such as fly and human, the role of this family in most invertebrates remains obscure. To fill this gap, we defined the evolutionary history of Rimbp family in animals, from sponges to mammals. We report, for the first time, the expression of the two isoforms of the unique Rimbp family member in Ciona robusta in distinct domains of the larval nervous system. We identify intronic enhancers that are able to drive expression in different nervous system territories partially corresponding to Rimbp endogenous expression. The analysis of gene expression patterns and the identification of regulatory elements of Rimbp will positively impact our understanding of this family of genes in the context of Ciona embryogenesis.
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Sánchez, Alejandro, Carlos Castro, Dora-Luz Flores, Everardo Gutiérrez, and Pierre Baldi. "Gap Junction Channels of Innexins and Connexins: Relations and Computational Perspectives." International Journal of Molecular Sciences 20, no. 10 (2019): 2476. http://dx.doi.org/10.3390/ijms20102476.
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Gap junction (GJ) channels in invertebrates have been used to understand cell-to-cell communication in vertebrates. GJs are a common form of intercellular communication channels which connect the cytoplasm of adjacent cells. Dysregulation and structural alteration of the gap junction-mediated communication have been proven to be associated with a myriad of symptoms and tissue-specific pathologies. Animal models relying on the invertebrate nervous system have exposed a relationship between GJs and the formation of electrical synapses during embryogenesis and adulthood. The modulation of GJs as a therapeutic and clinical tool may eventually provide an alternative for treating tissue formation-related diseases and cell propagation. This review concerns the similarities between Hirudo medicinalis innexins and human connexins from nucleotide and protein sequence level perspectives. It also sets forth evidence of computational techniques applied to the study of proteins, sequences, and molecular dynamics. Furthermore, we propose machine learning techniques as a method that could be used to study protein structure, gap junction inhibition, metabolism, and drug development.
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Weinmaster, G., V. J. Roberts, and G. Lemke. "A homolog of Drosophila Notch expressed during mammalian development." Development 113, no. 1 (1991): 199–205. http://dx.doi.org/10.1242/dev.113.1.199.
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Drosophila Notch and the related Caenorhabditis elegans proteins lin-12 and glp-1 function as mediators of local cell-cell interactions required for cell-fate decisions during invertebrate development. To investigate the possibility that similar proteins play determinative roles during mammalian development, we isolated cDNA clones encoding rat Notch. The deduced amino acid sequence of this protein contains 36 epidermal growth factor (EGF)-like repeats, and is remarkably similar in both its extracellular and cytoplasmic domains to the sequence of Xenopus Xotch and Drosophila Notch. In the developing central nervous system, in situ hybridisation analyses revealed that Notch transcripts were dramatically restricted to the ventricular proliferative zones of embryonic neuroepithelia. Notch was also strongly expressed during development of non-neural tissues, such as hair follicles and tooth buds, whose correct differentiation requires epithelial-mesenchymal interactions. These data support the hypothesis that Notch plays an essential role in mammalian development and pattern formation that closely parallels its role in the development of invertebrates.
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Elphick, Maurice R., and Michaelà Egertova. "The neurobiology and evolution of cannabinoid signalling." Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 356, no. 1407 (2001): 381–408. http://dx.doi.org/10.1098/rstb.2000.0787.
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The plant Cannabis sativa has been used by humans for thousands of years because of its psychoactivity. The major psychoactive ingredient of cannabis is δ 9 –tetrahydrocannabinol, which exerts effects in the brain by binding to a G–protein–coupled receptor known as the CB 1 cannabinoid receptor. The discovery of this receptor indicated that endogenous cannabinoids may occur in the brain, which act as physiological ligands for CB 1 . Two putative endocannabinoid ligands, arachidonylethanolamide (‘anandamide’) and 2–arachidonylglycerol, have been identified, giving rise to the concept of a cannabinoid signalling system. Little is known about how or where these compounds are synthesized in the brain and how this relates to CB 1 expression. However, detailed neuroanatomical and electrophysiological analysis of mammalian nervous systems has revealed that the CB 1 receptor is targeted to the presynaptic terminals of neurons where it acts to inhibit release of ‘classical’ neurotransmitters. Moreover, an enzyme that inactivates endocannabinoids, fatty acid amide hydrolase, appears to be preferentially targeted to the somatodendritic compartment of neurons that are postsynaptic to CB 1 –expressing axon terminals. Based on these findings, we present here a model of cannabinoid signalling in which anandamide is synthesized by postsynaptic cells and acts as a retrograde messenger molecule to modulate neurotransmitter release from presynaptic terminals. Using this model as a framework, we discuss the role of cannabinoid signalling in different regions of the nervous system in relation to the characteristic physiological actions of cannabinoids in mammals, which include effects on movement, memory, pain and smooth muscle contractility. The discovery of the cannabinoid signalling system in mammals has prompted investigation of the occurrence of this pathway in non–mammalian animals. Here we review the evidence for the existence of cannabinoid receptors in non–mammalian vertebrates and invertebrates and discuss the evolution of the cannabinoid signalling system. Genes encoding orthologues of the mammalian CB 1 receptor have been identified in a fish, an amphibian and a bird, indicating that CB 1 receptors may occur throughout the vertebrates. Pharmacological actions of cannabinoids and specific binding sites for cannabinoids have been reported in several invertebrate species, but the molecular basis for these effects is not known. Importantly, however, the genomes of the protostomian invertebrates Drosophila melanogaster and Caenorhabditis elegans do not contain CB 1 orthologues, indicating that CB 1 –like cannabinoid receptors may have evolved after the divergence of deuterostomes (e.g. vertebrates and echinoderms) and protostomes. Phylogenetic analysis of the relationship of vertebrate CB 1 receptors with other G–protein–coupled receptors reveals that the paralogues that appear to share the most recent common evolutionary origin with CB 1 are lysophospholipid receptors, melanocortin receptors and adenosine receptors. Interestingly, as with CB 1 , each of these receptor types does not appear to have Drosophila orthologues , indicating that this group of receptors may not occur in protostomian invertebrates. We conclude that the cannabinoid signalling system may be quite restricted in its phylogenetic distribution, probably occurring only in the deuterostomian clade of the animal kingdom and possibly only in vertebrates.
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Moroz, K. O. "Functional asymmetry of invertebrates’ nervous system on the example of spatial orientation of the Tentyriini tribe beetles." Biosystems Diversity 18, no. 2 (2010): 39–45. http://dx.doi.org/10.15421/011024.
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The functional asymmetry of the nervous system of insects was studied on an example of two taxonomically and ecologically closed darkling beetles: Anatolica eremita (Steven, 1829) and Tentiria nomas taurica (Pallas, 1781). Species-specificity of motor-spatial asymmetry is revealed for imago of these species. Spatial differentiation of specimens’ movement for “right-handers”, “left-handers” and “ambidexters” with different degree of the sign display was investigated. Fluctuations and distributing of values of the asymmetry ratio for both species of the darkling beetles were determined. Influence of the first priority of the locomotion direction on further orientational manifestations was analysed.
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Zulfiker, Abu Hasanat, Gian Mariottini, Ji Qi, I. Grice, and Ming Wei. "Indolealkylamines from Toad Vertebrates and Sea Invertebrates - Their Identification and Potential Activities on the Central Nervous System." Central Nervous System Agents in Medicinal Chemistry 16, no. 3 (2016): 197–207. http://dx.doi.org/10.2174/1871524915666150724100245.
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Scotland, Paula, Daixing Zhou, Helene Benveniste, and Vann Bennett. "Nervous System Defects of AnkyrinB (−/−) Mice Suggest Functional Overlap between the Cell Adhesion Molecule L1 and 440-kD AnkyrinB in Premyelinated Axons." Journal of Cell Biology 143, no. 5 (1998): 1305–15. http://dx.doi.org/10.1083/jcb.143.5.1305.
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The L1 CAM family of cell adhesion molecules and the ankyrin family of spectrin-binding proteins are candidates to collaborate in transcellular complexes used in diverse contexts in nervous systems of vertebrates and invertebrates. This report presents evidence for functional coupling between L1 and 440-kD ankyrinB in premyelinated axons in the mouse nervous system. L1 and 440-kD ankyrinB are colocalized in premyelinated axon tracts in the developing nervous system and are both down-regulated after myelination. AnkyrinB (−/−) mice exhibit a phenotype similar to, but more severe, than L1 (−/−) mice and share features of human patients with L1 mutations. AnkyrinB (−/−) mice exhibit hypoplasia of the corpus callosum and pyramidal tracts, dilated ventricles, and extensive degeneration of the optic nerve, and they die by postnatal day 21. AnkyrinB (−/−) mice have reduced L1 in premyelinated axons of long fiber tracts, including the corpus callosum, fimbria, and internal capsule in the brain, and pyramidal tracts and lateral columns of the spinal cord. L1 was evident in the optic nerve at postnatal day 1 but disappeared by postnatal day 7 in mutant mice while NCAM was unchanged. Optic nerve axons of ankyrinB (−/−) mice become dilated with diameters up to eightfold greater than normal, and they degenerated by day 20. These findings provide the first evidence for a role of ankyrinB in the nervous system and support an interaction between 440-kD ankyrinB and L1 that is essential for maintenance of premyelinated axons in vivo.
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Malin, Jennifer, and Claude Desplan. "Neural specification, targeting, and circuit formation during visual system assembly." Proceedings of the National Academy of Sciences 118, no. 28 (2021): e2101823118. http://dx.doi.org/10.1073/pnas.2101823118.
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Like other sensory systems, the visual system is topographically organized: Its sensory neurons, the photoreceptors, and their targets maintain point-to-point correspondence in physical space, forming a retinotopic map. The iterative wiring of circuits in the visual system conveniently facilitates the study of its development. Over the past few decades, experiments in Drosophila have shed light on the principles that guide the specification and connectivity of visual system neurons. In this review, we describe the main findings unearthed by the study of the Drosophila visual system and compare them with similar events in mammals. We focus on how temporal and spatial patterning generates diverse cell types, how guidance molecules distribute the axons and dendrites of neurons within the correct target regions, how vertebrates and invertebrates generate their retinotopic map, and the molecules and mechanisms required for neuronal migration. We suggest that basic principles used to wire the fly visual system are broadly applicable to other systems and highlight its importance as a model to study nervous system development.
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Yonesi, Mahdi, Mario Garcia-Nieto, Gustavo V. Guinea, Fivos Panetsos, José Pérez-Rigueiro, and Daniel González-Nieto. "Silk Fibroin: An Ancient Material for Repairing the Injured Nervous System." Pharmaceutics 13, no. 3 (2021): 429. http://dx.doi.org/10.3390/pharmaceutics13030429.
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Silk refers to a family of natural fibers spun by several species of invertebrates such as spiders and silkworms. In particular, silkworm silk, the silk spun by Bombyx mori larvae, has been primarily used in the textile industry and in clinical settings as a main component of sutures for tissue repairing and wound ligation. The biocompatibility, remarkable mechanical performance, controllable degradation, and the possibility of producing silk-based materials in several formats, have laid the basic principles that have triggered and extended the use of this material in regenerative medicine. The field of neural soft tissue engineering is not an exception, as it has taken advantage of the properties of silk to promote neuronal growth and nerve guidance. In addition, silk has notable intrinsic properties and the by-products derived from its degradation show anti-inflammatory and antioxidant properties. Finally, this material can be employed for the controlled release of factors and drugs, as well as for the encapsulation and implantation of exogenous stem and progenitor cells with therapeutic capacity. In this article, we review the state of the art on manufacturing methodologies and properties of fiber-based and non-fiber-based formats, as well as the application of silk-based biomaterials to neuroprotect and regenerate the damaged nervous system. We review previous studies that strategically have used silk to enhance therapeutics dealing with highly prevalent central and peripheral disorders such as stroke, Alzheimer’s disease, Parkinson’s disease, and peripheral trauma. Finally, we discuss previous research focused on the modification of this biomaterial, through biofunctionalization techniques and/or the creation of novel composite formulations, that aim to transform silk, beyond its natural performance, into more efficient silk-based-polymers towards the clinical arena of neuroprotection and regeneration in nervous system diseases.
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Sarnat, Harvey B., and Martin G. Netsky. "The Brain of the Planarian as the Ancestor of the Human Brain." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 12, no. 4 (1985): 296–302. http://dx.doi.org/10.1017/s031716710003537x.
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ABSTRACT:The planarian is the simplest living animal having a body plan of bilateral symmetry and cephalization. The brain of these free-living flatworms is a biiobed structure with a cortex of nerve cells and a core of nerve fibres including some that decussate to form commissures. Special sensory input from chemoreceptors, photoreceptor cells of primitive eyes, and tactile receptors are integrated to provide motor responses of the entire body, and local reflexes. Many morphological, electrophysiological, and pharmacological features of planarian neurons, as well as synaptic organization, are reminiscent of the vertebrate brain. Multipolar neurons and dendritic spines are rare in higher invertebrates, but are found in the planarian. Several neurotransmitter substances identified in the human brain also occur in the planarian nervous system. The planarian evolved before the divergence of the phylogenetic line leading to vertebrates. This simple worm therefore is suggested as a living example of the early evolution of the vertebrate brain. An extraordinary plasticity and regenerative capacity, and sensitivity to neurotoxins, provide unique opportunities for studying the reorganization of the nervous system after injury. Study of this simple organism may also contribute to a better understanding of the evolution of the human nervous system.
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Nave, Klaus-Armin, and Hauke B. Werner. "Ensheathment and Myelination of Axons: Evolution of Glial Functions." Annual Review of Neuroscience 44, no. 1 (2021): 197–219. http://dx.doi.org/10.1146/annurev-neuro-100120-122621.
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Myelination of axons provides the structural basis for rapid saltatory impulse propagation along vertebrate fiber tracts, a well-established neurophysiological concept. However, myelinating oligodendrocytes and Schwann cells serve additional functions in neuronal energy metabolism that are remarkably similar to those of axon-ensheathing glial cells in unmyelinated invertebrates. Here we discuss myelin evolution and physiological glial functions, beginning with the role of ensheathing glia in preventing ephaptic coupling, axoglial metabolic support, and eliminating oxidative radicals. In both vertebrates and invertebrates, axoglial interactions are bidirectional, serving to regulate cell fate, nerve conduction, and behavioral performance. One key step in the evolution of compact myelin in the vertebrate lineage was the emergence of the open reading frame for myelin basic protein within another gene. Several other proteins were neofunctionalized as myelin constituents and help maintain a healthy nervous system. Myelination in vertebrates became a major prerequisite of inhabiting new ecological niches.
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Negrón-Piñeiro, Lenny J., Yushi Wu, and Anna Di Gregorio. "Transcription Factors of the bHLH Family Delineate Vertebrate Landmarks in the Nervous System of a Simple Chordate." Genes 11, no. 11 (2020): 1262. http://dx.doi.org/10.3390/genes11111262.
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Tunicates are marine invertebrates whose tadpole-like larvae feature a highly simplified version of the chordate body plan. Similar to their distant vertebrate relatives, tunicate larvae develop a regionalized central nervous system and form distinct neural structures, which include a rostral sensory vesicle, a motor ganglion, and a caudal nerve cord. The sensory vesicle contains a photoreceptive complex and a statocyst, and based on the comparable expression patterns of evolutionarily conserved marker genes, it is believed to include proto-hypothalamic and proto-retinal territories. The evolutionarily conserved molecular fingerprints of these landmarks of the vertebrate brain consist of genes encoding for different transcription factors, and of the gene batteries that they control, and include several members of the bHLH family. Here we review the complement of bHLH genes present in the streamlined genome of the tunicate Ciona robusta and their current classification, and summarize recent studies on proneural bHLH transcription factors and their expression territories. We discuss the possible roles of bHLH genes in establishing the molecular compartmentalization of the enticing nervous system of this unassuming chordate.
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Fodor, István, Réka Svigruha, György Kemenes, Ildikó Kemenes, and Zsolt Pirger. "The Great Pond Snail (Lymnaea stagnalis) as a Model of Aging and Age-Related Memory Impairment: An Overview." Journals of Gerontology: Series A 76, no. 6 (2021): 975–82. http://dx.doi.org/10.1093/gerona/glab014.
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Abstract With the increase of life span, normal aging and age-related memory decline are affecting an increasing number of people; however, many aspects of these processes are still not fully understood. Although vertebrate models have provided considerable insights into the molecular and electrophysiological changes associated with brain aging, invertebrates, including the widely recognized molluscan model organism, the great pond snail (Lymnaea stagnalis), have proven to be extremely useful for studying mechanisms of aging at the level of identified individual neurons and well-defined circuits. Its numerically simpler nervous system, well-characterized life cycle, and relatively long life span make it an ideal organism to study age-related changes in the nervous system. Here, we provide an overview of age-related studies on L. stagnalis and showcase this species as a contemporary choice for modeling the molecular, cellular, circuit, and behavioral mechanisms of aging and age-related memory impairment.
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Rui, Menglong, Shufeng Bu, Liang Yuh Chew, Qiwei Wang, and Fengwei Yu. "The membrane protein Raw regulates dendrite pruning via the secretory pathway." Development 147, no. 19 (2020): dev191155. http://dx.doi.org/10.1242/dev.191155.
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ABSTRACTNeuronal pruning is essential for proper wiring of the nervous systems in invertebrates and vertebrates. Drosophila ddaC sensory neurons selectively prune their larval dendrites to sculpt the nervous system during early metamorphosis. However, the molecular mechanisms underlying ddaC dendrite pruning remain elusive. Here, we identify an important and cell-autonomous role of the membrane protein Raw in dendrite pruning of ddaC neurons. Raw appears to regulate dendrite pruning via a novel mechanism, which is independent of JNK signaling. Importantly, we show that Raw promotes endocytosis and downregulation of the conserved L1-type cell-adhesion molecule Neuroglian (Nrg) prior to dendrite pruning. Moreover, Raw is required to modulate the secretory pathway by regulating the integrity of secretory organelles and efficient protein secretion. Mechanistically, Raw facilitates Nrg downregulation and dendrite pruning in part through regulation of the secretory pathway. Thus, this study reveals a JNK-independent role of Raw in regulating the secretory pathway and thereby promoting dendrite pruning.
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Sadamoto, Hisayo, Hironobu Takahashi, Suguru Kobayashi, Hirooki Kondoh, and Hiroshi Tokumaru. "Identification and classification of innexin gene transcripts in the central nervous system of the terrestrial slug Limax valentianus." PLOS ONE 16, no. 4 (2021): e0244902. http://dx.doi.org/10.1371/journal.pone.0244902.
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Intercellular gap junction channels and single-membrane channels have been reported to regulate electrical synapse and the brain function. Innexin is known as a gap junction-related protein in invertebrates and is involved in the formation of intercellular gap junction channels and single-cell membrane channels. Multiple isoforms of innexin protein in each species enable the precise regulation of channel function. In molluscan species, sequence information of innexins is still limited and the sequences of multiple innexin isoforms have not been classified. This study examined the innexin transcripts expressed in the central nervous system of the terrestrial slugLimax valentianusand identified 16 transcripts of 12 innexin isoforms, including the splicing variants. We performed phylogenetic analysis and classified the isoforms with other molluscan innexin sequences. Next, the phosphorylation, N-glycosylation, and S-nitrosylation sites were predicted to characterize the innexin isoforms. Further, we identified 16 circular RNA sequences of nine innexin isoforms in the central nervous system ofLimax. The identification and classification of molluscan innexin isoforms provided novel insights for understanding the regulatory mechanism of innexin in this phylum.
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Keating, C. D., L. Holden-Dye, M. C. Thorndyke, R. G. Williams, A. Mallett, and R. J. Walker. "The FMRFamide-like neuropeptide AF2 is present in the parasitic nematode Haemonchus contortus." Parasitology 111, no. 4 (1995): 515–21. http://dx.doi.org/10.1017/s0031182000066026.
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SUMMARYPeptides belonging to the FMRFamide family are widely distributed amongst invertebrates. We report here on the isolation of the FMRFamide neuropeptide AF2 (Lys-His-Glu-Tyr-Leu-Arg-Phe-NH2) from the parasitic nematode Haemonchus contortus. Immunocytochemical techniques showed that FMRFamide-like material was distributed in several regions of these organisms including nerve cords and cell bodies of the central nervous system. AF2 was isolated using a method that employed 6 steps of reverse-phase HPLC. The concentration of AF2 in this organism was approximately 30 pmol/g of nematode.
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Soya, Seçkin, Umut Şahar, Mehmet Yıkılmaz, and Sabire Karaçalı. "Determination of sialic acids in the nervous system of silkworm (Bombyx mori L.): Effects of aging and development." Archives of Biological Sciences 69, no. 2 (2017): 369–78. http://dx.doi.org/10.2298/abs160401117s.
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Sialic acids mainly occur as components on cell surface glycoproteins and glycolipids. They play a major role in the chemical and biological diversity of glycoconjugates. Although sialic acids exhibit great structural variability in vertebrates, glycoconjugates with sialic acids have also been determined in small amounts in invertebrates. It has been suggested that sialic acids play important roles in the development and function of the nervous system. Despite Bombyx mori being a model organism for the investigation of many physiological processes, sialic acid changes in its nervous system have not been examined during development and aging. Therefore, in this study we aimed to determine sialic acid changes in the nervous system of Bombyx mori during development and aging processes. Liquid chromatography-mass spectrometry (LC-MS) and lectin immunohistochemistry were carried out in order to find variations among different developmental stages. Developmental stages were selected as 3rd instar (the youngest) and 5th larval instar (young), motionless prepupa (the oldest) and 13-day-old pupa (adult development). At all stages, only Neu5Ac was present, however, it dramatically decreased during the developmental and aging stages. On the other hand, an increase was observed in the amount of Neu5Ac during the pupal stage. In immunohistochemistry experiments with Maackia amurensis agglutinin (MAA) and Sambucus nigra agglutinin (SNA) lectins, the obtained staining was consistent with the obtained LC-MS results. These findings indicate that sialic acids are abundant at the younger stages but that they decrease in the insect nervous system during development and aging, similarly as in mammals.
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Cowen, Philip J. "Serotonin – 100 words." British Journal of Psychiatry 203, no. 1 (2013): 23. http://dx.doi.org/10.1192/bjp.bp.112.108506.
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Serotonin is a neurotransmitter conserved through at least 500 million years of nervous system evolution. Serotonin orchestrates adaptive responses to aversive stimuli in invertebrates and an analogous role can be discerned in the more complex behavioural repertoire displayed by mammals to adversity. However, this formulation fails to capture the range of human social behaviours influenced by serotonin, for example, affiliation, empathy and cooperation. In a psychopharmacology experiment I received paroxetine for three weeks. This boost in brain serotonin levels failed to alter my subjective ratings of mood and anxiety. My wife felt differently; ‘Can't you stay on it?’, she said.
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Sasayama, Yuichi, Ayumi Katoh, Chitaru Oguro, Akira Kambegawa, and Hideki Yoshizawa. "Cells showing immunoreactivity for calcitonin or calcitonin gene-related peptide (CGRP) in the central nervous system of some invertebrates." General and Comparative Endocrinology 83, no. 3 (1991): 406–14. http://dx.doi.org/10.1016/0016-6480(91)90146-w.
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