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1

Schwarz, Quenten, and Sophie Wiszniak, eds. Neural Crest Cells. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9412-0.

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Hall, Brian K., ed. The Neural Crest and Neural Crest Cells in Vertebrate Development and Evolution. Springer US, 2009. http://dx.doi.org/10.1007/978-0-387-09846-3.

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3

Perris, Roberto. Cell-matrix interactions in neural crest development. Univ., 1987.

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4

Maya, Sieber-Blum, ed. Neurotrophins and the neural crest. CRC Press, 1999.

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5

Neural Crest Cells. Elsevier, 2014. http://dx.doi.org/10.1016/c2012-0-00698-9.

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6

Medeiros, Daniel Meulemans, Brian Frank Eames, and Igor Adameyko. Evolving Neural Crest Cells. Taylor & Francis Group, 2020.

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7

Sieber-Blum, Maya. Neural Crest Stem Cells. WORLD SCIENTIFIC, 2011. http://dx.doi.org/10.1142/8127.

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8

Medeiros, Daniel Meulemans, Brian Frank Eames, and Igor Adameyko. Evolving Neural Crest Cells. Taylor & Francis Group, 2020.

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9

Medeiros, Daniel Meulemans, Brian Frank Eames, and Igor Adameyko. Evolving Neural Crest Cells. Taylor & Francis Group, 2020.

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10

Medeiros, Daniel Meulemans, Brian Frank Eames, and Igor Adameyko. Evolving Neural Crest Cells. Taylor & Francis Group, 2022.

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11

Medeiros, Daniel Meulemans, Brian Frank Eames, and Igor Adameyko. Evolving Neural Crest Cells. Taylor & Francis Group, 2020.

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12

Schwarz, Quenten, and Sophie Wiszniak. Neural Crest Cells: Methods and Protocols. Springer New York, 2020.

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13

Neural Crest Cells: Methods and Protocols. Springer New York, 2019.

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14

Hall, Brian K. The Neural Crest and Neural Crest Cells in Vertebrate Development and Evolution. Springer, 2010.

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15

Neural Crest Stem Cells Breakthroughs And Applications. World Scientific Publishing Company, 2012.

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16

Medeiros, Daniel Meulemans. Origin and Evolution of Neural Crest Cells. Taylor & Francis Group, 2020.

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17

(Editor), B. Kramer, and B. B. Rawdon (Editor), eds. Embryos, Endocrine Cells and the Neural Crest. Witwatersrand University Press, 1995.

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18

Trainor, Paul. Neural Crest Cells: Evolution, Development and Disease. Elsevier Science & Technology Books, 2013.

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19

Neural Crest Stem Cells: Breakthroughs and Applications. World Scientific Publishing Co Pte Ltd, 2012.

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20

Neural Crest Cells: Evolution, Development and Disease. Elsevier Science & Technology Books, 2013.

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21

Buchstaller, Johanna. Gene expression profiling of neural crest cells and developing Schwann cells. 2004.

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22

Dyer, Laura A., and Margaret L. Kirby. The role of the neural crest in cardiac development. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, et al. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0019.

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The cardiac neural crest (CNC) plays pivotal roles in numerous steps of cardiac development. Every aspect of the CNC cell’s lifespan is highly orchestrated, from its induction in the dorsal neural tube to its migration to its differentiation at its final destination. During migration, CNC cells are affected by their environment and simultaneously modulate the extra-cellular milieu through which they migrate. In the pharyngeal arches, CNC cells repattern the originally symmetrical arch arteries, producing the great arteries. Because the cardiac neural crest is essential for many aspects of hear
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23

Hall, Brian K. The Neural Crest and Neural Crest Cells in Vertebrate Development and Evolution (Springer series in solid-state sciences). Springer, 2008.

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24

Carpenter, Ellen Malinin. An analysis of the migration, location, and distribution of neural crest-derived Schwann cells in chick embryos. 1988.

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25

Pomeranz, Howard David. Formation of the enteric nervous system: Derivation of precursors from both sacral and vagal levels of the neural crest, pathways to the bowel followed by emigrés from the crest, and the ability of enteric crest-derived cells to interact with laminin. 1991.

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26

Kalcheim, Chaya, and Nicole Le Douarin. The Neural Crest (Developmental and Cell Biology Series). 2nd ed. Cambridge University Press, 1999.

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27

Rammah, Mayyasa, Francesca Rochais, and Robert G. Kelly. Incorporation of myocardial progenitors at the arterial pole of the heart. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, et al. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0007.

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The arterial pole of the heart is a hotspot for life-threatening forms of congenital heart defects (CHDs). It is formed by progressive addition of myocardium from epithelial progenitor cells in the second heart field (SHF). SHF cells contribute successively to the right ventricle and proximal and distal outflow tract myocardial walls which, after neural crest influx and cardiac septation, give rise to myocardium at the base of the aorta and pulmonary trunk. SHF cells are characterized by continued proliferation and differentiation delay controlled by an array of transcriptional regulators and
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28

Trainor, Paul. Neural Crest and Placodes. Elsevier Science & Technology Books, 2015.

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29

Trainor, Paul. Neural Crest and Placodes. Elsevier Science & Technology Books, 2015.

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30

Brown, Christina, and Meredith Kato. Neuroblastoma. Edited by Kirk Lalwani, Ira Todd Cohen, Ellen Y. Choi, and Vidya T. Raman. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190685157.003.0033.

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Neuroblastoma is a solid tumor that arises from neural crest cells. It is a common cancer of childhood, accounting for 7.8% of all childhood malignancy. It affects primarily infants and toddlers with older children carrying a worse prognosis. While surgery is a primary treatment modality, these tumors are not well encapsulated and tend to invade adjacent structures making resection more difficult. As such, patients often come to the operating room after neoadjuvant chemotherapy and the surgeries can be long with large blood losses. Anesthesia for the resection for neuroblastoma must take into
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31

Armstrong, Bruce K., Claire M. Vajdic, and Anne E. Cust. Melanoma. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0057.

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Melanoma is a cancer of melanocytes, cells that produce the brown-black skin pigment melanin. Melanocytes originate in cells of the neural crest and migrate during embryogenesis, principally to the epidermis, eyes, and some mucous membranes (mouth, nose, esophagus, anus, genitourinary organs, and conjunctiva). Cutaneous melanoma afflicts mainly fair-skinned people of European origin, among whom sun exposure is the major cause. Five-year relative survival can exceed 90%. Invasive cutaneous melanoma in US whites occurs mostly on the trunk (34%), and upper limbs and shoulders (26%). Melanoma inci
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32

Beltran, Ralph J. Pheochromocytoma. Edited by Kirk Lalwani, Ira Todd Cohen, Ellen Y. Choi, and Vidya T. Raman. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190685157.003.0044.

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Pheochromocytoma is a rare type of neoplasm diagnosed in children. It originates in the adrenal gland and is different from paragangliomas which arise outside the adrenals. Both types of tumors arise from neural crest cells and lead to signs and symptoms related to hypersecretion of catecholamines. Related symptoms include hypertension, tachycardia, episodic headache, sweating, and abdominal pain. These tumors may be associated with multiple endocrine type 2 syndrome, multiple endocrine neoplasia, and von Hippel-Lindau disease, among other hereditary conditions. Pheochromocytomas can be malign
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33

Zaffran, Stéphane. Cardiac growth II: Cardiomyocyte polarization. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, et al. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0010.

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During vertebrate embryogenesis, the planar cell polarity (PCP) signalling pathway is responsible for cell movements essential for convergent extension during gastrulation, neural tube closure, neural crest cell migration, and heart morphogenesis. In the heart, the non-canonical Wnt/PCP pathway regulates cell polarity, cell shape, and cell dynamics during formation of the cardiac crescent and deployment of second heart field cardiac progenitors to the poles of the heart tube. PCP signalling is also essential for the establishment of left–right patterning in the early embryo. This chapter revie
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34

Helbling, Paul M. EPH receptors in cranial neural crest cell migration and angiogenesis. 1999.

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35

Neural crest cell lineage restricts skeletal muscle progenitor cell differentiation through Neuregulin1-ErbB3 signaling. Developmental Cell, 2011.

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