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1

Qadree, Muhammad Shahzad, Syed Shakil-Ur Rehman, M. Usman Riaz, Mehwish Anees, and Hira Islam Rajput. "EFFECTS OF GRASTON INSTRUMENT SOFT TISSUE MOBILIZATION IN PATIENTS WITH SCIATIC NERVE ENTRAPMENT." Pakistan Journal of Rehabilitation 11, no. 2 (2022): 83–91. http://dx.doi.org/10.36283/pjr.zu.11.2/013.

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Background: Sciatica or more commonly sciatic nerve pain is characterized by low back pain that radiates down towards knee or below knee, paresthesia associated with tingling or numbness and weakness of muscles of foot and leg. Most important cause of sciatica is herniated disc which cause nerve root entrapment. Other causes may include lumbar stenosis or spinal tumors. The goal of the study is to determine the effects of graston instrument technique soft tissue mobilization in patients with sciatic nerve entrapment. Methods: Patients were recruited and allocated randomly in two groups. Group
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A Kaydawala, Batul, and Megha S Sheth. "Immediate Effect of Neural Tissue Mobilization on Tibial Nerve Mobility in Individuals with Flatfeet." International Journal of Health Sciences and Research 13, no. 2 (2023): 44–49. http://dx.doi.org/10.52403/ijhsr.20230208.

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Introduction: Tarsal tunnel syndrome is compression of the posterior tibial nerve as it travels through the tarsal tunnel. Individuals with flatfeet are prone to develop tarsal tunnel syndrome as there is outward tilting of heel which flattens the medial arch. Neural tissue mobilization is a manipulative technique by which neural tissues are moved and stretched either by movement relative to their surroundings or tension development. The aim of the study was to see the effect of neural tissue mobilization on tibial nerve mobility in subjects with flat feet. Methodology: An experimental study w
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Ajith kumar G P, Prathap Suganthirababu, Vignesh Srinivasan, et al. "Effectiveness of Postural Correction Versus Soft Tissue Techniques Along with Neural Mobilization in Management of Pain and Disability Associated with Cervicogenic Headache: A Comparative Study." Indian Journal of Physiotherapy & Occupational Therapy - An International Journal 18 (January 21, 2024): 85–91. http://dx.doi.org/10.37506/djq1e364.

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Background: This study was developed to compare the effect of soft tissue technique with neural mobilization andpostural correction with neural mobilization on pain and disability among patients with cervicogenic headache.Purpose: The purpose of the study was to control the pain and impairment related to cervicogenic headache(CGH), this study compares the effectiveness of two interventions: postural correction and soft tissue techniquescombined with neural mobilization.Materials and Methods: A sum of 30 participants were recruited, based on the selection criteria from the abovementionedstudy s
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Thomas, Sneha, and Rinkle Hotwani. "EFFECTIVENESS OF INTERMITTENT PELVIC TRACTION WITH AND WITHOUT SELF NEURAL TISSUE MOBILIZATION IN LUMBAR RADICULOPATHY." International Journal of Physiotherapy and Research 7, no. 3 (2019): 3069–76. http://dx.doi.org/10.16965/ijpr.2019.123.

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S. Santhosh and N. Priyanka. "A STUDY TO COMPARE THE EFFECTIVENESS OF SPINAL MOBILIZATION WITH ARM MOVEMENT VERSUS NEURAL TISSUE MOBILIZATION ALONG WITH MUSLE ENERGY TECHNIQUE AMONG CERVICAL RADICULOPATHY PATIENTS." Indian Journal of Physiotherapy and Occupational Therapy - An International Journal 18, Conf 1 (2024): 40. http://dx.doi.org/10.37506/6pqdmn92.

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Background: Cervical Radiculopathy is a disease of the cervical spine and a space occupying lesion that occurs because of pathological problems with cervical nerve roots. It usually causes the pain in the neck ,radiating to one arm with reduced motor function and reflex changes in the affected nerve root and commonly affect the middle aged to elderly person. Objective: A study to compare the effectiveness of spinal mobilization with arm movement versus neural tissue mobilization along with muscle energy technique among cervical radiculopathy patients. Method: Comparative study, 30 patients wer
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Souza de Faria, Suelen Carla, Renato Carvalho Vilella, Laiz Helena de Castro Toledo Guimaraes, and Luciana Crepaldi Lunkes. "Effects of neural mobilization in the treatment of chronic low back pain: a systematic review." Iberoamerican Journal of Medicine 4, no. 3 (2022): 157–63. http://dx.doi.org/10.53986/ibjm.2022.0028.

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Introduction: Low back pain appears in approximately two thirds of the population at some point in life and when it exceeds more than 12 weeks, it evolves to chronic low back pain. Chronic low back pain is considered one of the most common causes of disability and absence from work. A therapeutic technique that can be used as a treatment for chronic low back pain is neural mobilization, capable of restoring compromised neurological structures, restoring movement by improving the elasticity of neural tissue and adjacent tissues. Objective: To verify the effects of neural mobilization in patient
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Nar, Nishant H. "Effect of Neural Tissue Mobilization on Pain in Cervical Radiculopathy Patients." Indian Journal of Physiotherapy and Occupational Therapy - An International Journal 8, no. 1 (2014): 144. http://dx.doi.org/10.5958/j.0973-5674.8.1.028.

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Umeshbhai Joshi, Mahima, and Yagna Unmesh Shukla. "Effect of Self Neural Mobilization in Low Back Pain with Radiculopathy on Pain, ROM and Functional Disability - An Interventional Study." International Journal of Science and Healthcare Research 8, no. 4 (2023): 170–77. http://dx.doi.org/10.52403/ijshr.20230424.

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BACKGROUND: Leg pain extending below the knee into the foot and toes is lumbar radiculopathy, often accompanied by sensory, reflex or motor neurological problems along the lumbosacral nerves or nerve roots. Neural tissue mobilization techniques involve assessing and relieving neural tension through movements, restoring the nervous system's capacity to handle daily forces. These manual methods aid movement within neural structures and have been found, in research on both humans and animals, to reduce edema, enhance fluid dispersion, alleviate pain sensitivity, and reverse heightened immune resp
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Parshuram Nadkarni, Shruti, and Vaishali Jagtap. "Effectiveness Of Manual Lymphatic Drainage and Neural Tissue Mobilization in Lymphedema Secondary to Radical Mastectomy." Journal of Neonatal Surgery 14, no. 4 (2025): 83–88. https://doi.org/10.52783/jns.v14.2482.

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BackgroundA typical secondary consequence after a radical mastectomy for the treatment of breast cancer is lymphedema, a chronic and progressive disorder marked by abnormal fluid buildup in the interstitial tissues. This disorder, which causes swelling, pain, limited mobility, and a worse quality of life, is brought on by poor lymphatic drainage as a result of lymph node excision. In order to improve lymphatic flow and lessen edema, traditional treatment techniques include manual lymphatic drainage (MLD), exercise, and compression therapy. A therapy strategy called Neural Tissue Mobilization (
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Shekhawat, Devendra Singh, Harshita Kapoor, and Madhusudan Tiwari. "Improving Pain and Disability in Lower Back Pain with Neural Mobilization: A Systematic Review." Journal of Advances in Medicine and Medical Research 36, no. 10 (2024): 200–207. http://dx.doi.org/10.9734/jammr/2024/v36i105603.

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Background: Radiating pain in a leg region usually supplied by a single nerve root in the lumbar or sacral spine is the hallmark of sciatica; sensory and motor impairments may also be present. Neural mobilization is one therapy for lumbosacral radiculopathy on which physical therapists have placed a great deal of attention. Its goal is to mobilize peripheral neural tissue and surrounding tissues, which in turn affects the mechanical properties of peripheral nerves. NM can lessen the mechanical sensitivity of nerves and has a hypoalgesic impact. Methods: Systematic review of the studies reporti
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Godse, Apurva, Trupti Warude, Amrutkuvar Pawar, Vaishali Jagtap, Krishna Savsaviya, and Nilakshi Kandalkar. "Effectiveness of Spinal Mobilization with Arm Movement (Smwams) Versus neural Tissue Mobilization in cervical Spondylosis with Unilateral radiculopathy." Indian Journal of Public Health Research & Development 10, no. 5 (2019): 24. http://dx.doi.org/10.5958/0976-5506.2019.00963.x.

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Aniruddha, Pradyuman Barot, and Unmesh Shukla Yagna. "Effects of Neural Tissue Mobilization versus Intermittent Cervical Traction in Unilateral Cervical Radiculopathy on Pain, Range of Motion and Quality of Life- A Comparative Study." International Journal of Science and Healthcare Research 5, no. 1 (2020): 132–42. https://doi.org/10.5281/zenodo.3930273.

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<strong>Introduction:</strong>&nbsp;The experience of pain is multi-dimensional &amp; it is therefore important to provide a holistic approach when assessing and managing pain. As there is paucity in literature comparing effects of neural tissue mobilization versus intermittent cervical traction in unilateral cervical radiculopathy on pain, range of motion&amp; quality of life, there was a need to conduct this study to fill the gap in the available literature. <strong>Materials &amp; Method:</strong>&nbsp;After taking informed, written consent patients were divided into 3 groups by simple rand
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Mendes, Alan Campelo, Maria Moreira Muniz, Rayany Gysely Miranda Da Silva, Rauena Souto Diogo Lopes, and Fabiana Teixeira De Carvalho. "Comparison of myofascial release af ter passive muscle stretching and neural mobilization on ROM of the hip." Manual Therapy, Posturology & Rehabilitation Journal 12 (June 4, 2014): 182. http://dx.doi.org/10.17784/mtprehabjournal.2014.12.182.

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Introduction: The hip joint is one that has more stability, but on the other hand has less mobility with respect to the shoulder joint, due to its greater amount of muscle tissue and ligaments. This large amount of muscles can undergo changes that hinder the amplitude motion, and shortening a key, with the posterior region of the thigh among the hardest hit targets. The neural mobilization and stretching myofascial release have benefits against this change. Objective: Compare effects of myofascial release is followed by a passive muscle stretching relation to neural mobilization on range of mo
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M Shaheen, Hamza, Rawan Tebakhi, Lozan Alfroukh, and Khaled Sabarna. "Tensioner neural mobilization performance utilization in the treatment of patients with radicular low back pain." Cuestiones de Fisioterapia 53, no. 03 (2024): 2455–67. https://doi.org/10.48047/wgkgsy93.

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Background: Low back pain (LBP) poses as one of the worldwide health problems which disrupts posturewhile reducing functional abilities. The condition develops because of faulty posture and tissue injuries as wellas emotional factors. Chronic back pain patients mostly receive physiotherapy treatment at the initial stageusing different therapeutic methods to relieve their symptoms and enhance their performance level. Researchhas focused on the tensioner approach within neural mobilization therapy because of its promising effects onmanaging LBP.
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15

Solanki, Hiral R. "A Comparative Study to Determine the Effectiveness of Neural Tissue Mobilization v/s IFT for Sciatica." Indian Journal of Physiotherapy and Occupational Therapy - An International Journal 9, no. 4 (2015): 142. http://dx.doi.org/10.5958/0973-5674.2015.00161.6.

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Patel, Gatha, Khushboo Bathia, Smita Kanase, Amrutkuvar Pawar, Vishnupriya Deshpande, and Prachi Jain. "Effectiveness of Self Myofascial Release, Static Stretching and Neural Tissue Mobilization on Hamstring Flexibility in Athletes." Indian Journal of Public Health Research & Development 10, no. 4 (2019): 6. http://dx.doi.org/10.5958/0976-5506.2019.00656.9.

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Bhagat, Amisha. "INTEGRATED APPROACH TO PAIN MANAGEMENT: YOGA, MANUAL THERAPY, FASCIA RELEASE, NERVE MOBILIZATION TECHNIQUES, OSTEOPATHIC MANIPULATIVE TREATMENT, CHIROPRACTIC CARE AND KINEMATIC AND KINETIC CHAINSANALYSIS& MUSCULOSKELETAL DYNAMICS." International Journal of Advanced Research 12, no. 03 (2024): 90–107. http://dx.doi.org/10.21474/ijar01/18369.

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Chronic pain affects millions worldwide, presenting a complex challenge to conventional medical approaches. This abstract explores an integrated approach to pain management, amalgamating principles from yoga, manual therapy, fascia release, nerve mobilization, Osteopathic Manipulative Treatment, Chiropractic Careand Kinematic and Kinetic ChainsAnalysis and Musculoskeletal Dynamics. By synergizing these modalities, practitioners address pain comprehensively, targeting its multifaceted origins and manifestations.Yoga, renowned for its mind-body connection, offers a repertoire of postures and bre
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Lucha-López, María Orosia, César Hidalgo-García, Sofía Monti-Ballano, et al. "Diacutaneous Fibrolysis: An Update on Research into Musculoskeletal and Neural Clinical Entities." Biomedicines 11, no. 12 (2023): 3122. http://dx.doi.org/10.3390/biomedicines11123122.

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Diacutaneous Fibrolysis (DF) is an instrumentally assisted manual therapy technique defined as “a specific instrumental intervention for normalizing the musculoskeletal system function after a precise diagnosis and preserving the skin’s integrity”. The aim of this technique is soft tissue mobilization with the assistance of specially designed, hook-shaped steel instruments in different musculoskeletal structures, such as the myofascia, aponeurosis, tendons, ligaments and scar tissues. Due to discrepant results between previous reviews and the quite abundant new evidence provided by recently pu
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Kucia, Magda, Edyta Paczkowska, Marcin Majka, Bogdan Machalinski, and Mariusz Z. Ratajczak. "Evidence That Functional Neural Tissue-Committed Stem Cells (NTCSC) Reside in the Human Bone Marrow and Are Mobilized into Peripheral Blood in a Patients after Stroke." Blood 106, no. 11 (2005): 392. http://dx.doi.org/10.1182/blood.v106.11.392.392.

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Abstract The concept that bone marrow (BM)-derived cells participate in neural regeneration remains highly controversial and the identity of the specific cell type(s) involved remains unknown. We recently reported that murine BM contains a highly mobile population of CXCR4+ cells that express mRNA for various markers of early tissue-committed stem cells (TCSC), including neural TCSC (Leukemia2004:18;29–40). Here we show that these cells could be isolated from murine BM as a population of Sca-1+lin− CD45− cells that not only express neural lineage markers (β-III-tubulin, Nestin, NeuN and GFAP),
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Zhu, Qi, Bradley J. Glazier, Benjamin C. Hinkel, et al. "Neuroendocrine Regulation of Energy Metabolism Involving Different Types of Adipose Tissues." International Journal of Molecular Sciences 20, no. 11 (2019): 2707. http://dx.doi.org/10.3390/ijms20112707.

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Despite tremendous research efforts to identify regulatory factors that control energy metabolism, the prevalence of obesity has been continuously rising, with nearly 40% of US adults being obese. Interactions between secretory factors from adipose tissues and the nervous system innervating adipose tissues play key roles in maintaining energy metabolism and promoting survival in response to metabolic challenges. It is currently accepted that there are three types of adipose tissues, white (WAT), brown (BAT), and beige (BeAT), all of which play essential roles in maintaining energy homeostasis.
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Hagan, Christopher R., Alexandra R. Anderson, and Craig P. Hensley. "Lumbar Spine and Neural Tissue Mobilizations Improve Outcomes in Runners Presenting With Foot/Ankle Pathology: A Case Series." Journal of Sport Rehabilitation 33, no. 7 (2024): 549–55. http://dx.doi.org/10.1123/jsr.2024-0035.

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Context: Foot/ankle pain is common among runners. Inadequate management of runners with foot/ankle pain can lead to lost training time, competition removal, and other activity limitations. Neurodynamics, which refers to the integrated biomechanical, physiological, and structural function of the nervous system during movement, can be overlooked in patients with foot/ankle pain. Although a link between the cervical spine, neurodynamics, and upper quarter pain has been studied, less is known about the relationship between the lumbar spine and lower quarter. This case series describes the successf
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Muir, Keith W. "Stem cells in stroke management." Reviews in Clinical Gerontology 21, no. 2 (2010): 125–40. http://dx.doi.org/10.1017/s0959259810000390.

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SummaryStem cells are a potential means of tissue regeneration in the brain that hold promise for treatment of the large number of stroke survivors who have permanent disability. Animal studies with stem cells derived from many different sources indicate that cells can migrate to the site of ischaemic injury in the brain, and that some survive and differentiate into neurones and glia with evidence of electrical function. Cells additionally promote endogenous repair mechanisms, including mobilization of neural stem cells resident within the adult brain. Whether the behavioural benefits seen wit
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Liaqat, Rabia, and Aneela Zia. "Dose response of neural mobilization on hamstring flexibility in patients with non-specific low back pain: a randomized control trial." Rehabilitation Journal 09, no. 02 (2025): 27–33. https://doi.org/10.52567/trehabj.v9i02.107.

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Background: Non-specific low back pain (NSLBP) often correlates with reduced hamstring flexibility, contributing to altered biomechanics and recurrent symptoms. Neural mobilization (NM) techniques are increasingly integrated into management strategies to address neurogenic inflammation and neural tissue mobility. However, the dose-response relationship of NM for hamstring flexibility remains unclear, with limited studies isolating dosage effects amid multimodal interventions. Objectives: to determine the dose-response effect of NM on hamstring flexibility, pain, and disability in NSLBP patient
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Kucia, Magda, Ryan Reca, Marcin Wysoczynski, et al. "A Potential New Application of Mobilization/Leukapheresis for Enrichment of Peripheral Blood in Circulating Non-Hematopoietic CXCR4+CD45− Tissue-Committed Stem Cells (TCSC) for Organ/Tissue Regeneration." Blood 104, no. 11 (2004): 151. http://dx.doi.org/10.1182/blood.v104.11.151.151.

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Abstract During mobilization hematopoietic stem cells (HSC) egress from the bone marrow (BM) into peripheral blood (PB) where they temporarily circulate and can be collected by leukapheresis. However, recently we demonstrated that BM, in addition to HSC, contains heterogeneous populations of CXCR4+ tissue-committed stem cells (TCSC) and we contend that the contribution of these cells to organ/tissue regeneration after transplantation of BM cells has been misinterpreted as evidence for “plasticity” or “trans-dedifferentiation” of HSC (Leukemia2004:18;29–40). To determine whether TCSC could also
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Joshi, Devanshi, Sakshi Shah, Sandeep Shinde, and Sanjaykumar Patil. "Effect of Neural Tissue Mobilization on Sensory-Motor Impairments in Breast Cancer Survivors with Lymphedema: An Experimental Study." Asian Pacific Journal of Cancer Prevention 24, no. 1 (2023): 313–19. http://dx.doi.org/10.31557/apjcp.2023.24.1.313.

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Bartness, Timothy J., C. Kay Song, Haifei Shi, Robert R. Bowers, and Michelle T. Foster. "Brain–adipose tissue cross talk." Proceedings of the Nutrition Society 64, no. 1 (2005): 53–64. http://dx.doi.org/10.1079/pns2004409.

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While investigating the reversible seasonal obesity of Siberian hamsters, direct sympathetic nervous system (SNS) postganglionic innervation of white adipose tissue (WAT) has been demonstrated using anterograde and retrograde tract tracers. The primary function of this innervation is lipid mobilization. The brain SNS outflow to WAT has been defined using the pseudorabies virus (PRV), a retrograde transneuronal tract tracer. These PRV-labelled SNS outflow neurons are extensively co-localized with melanocortin-4 receptor mRNA, which, combined with functional data, suggests their involvement in l
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Bartness, Timothy J., and Maryam Bamshad. "Innervation of mammalian white adipose tissue: implications for the regulation of total body fat." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 275, no. 5 (1998): R1399—R1411. http://dx.doi.org/10.1152/ajpregu.1998.275.5.r1399.

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We review the extensive physiological and neuroanatomical evidence for the innervation of white adipose tissue (WAT) by the sympathetic nervous system (SNS) as well as what is known about the sensory innervation of this tissue. The SNS innervation of WAT appears to be a part of the general SNS outflow from the central nervous system, consisting of structures and connections throughout the neural axis. The innervation of WAT by the SNS could play a role in the regulation of total body fat in general, most likely plays an important role in regional differences in lipid mobilization specifically,
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Panjwani, Khushboo D. "To Compare the Effect of MWM v/s MWM along with Neural Tissue Mobilization in Case of Cervical Radiculopathy." Indian Journal of Physiotherapy and Occupational Therapy - An International Journal 10, no. 1 (2016): 42. http://dx.doi.org/10.5958/0973-5674.2016.00010.1.

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Ganesh and Sonam Bhambhani. "Effectiveness of neural tissue mobilization in the management of cervicobrachial pain in subjects between age group 25–40 years." Indian Journal of Physiotherapy and Occupational Therapy - An International Journal 13, no. 1 (2019): 149. http://dx.doi.org/10.5958/0973-5674.2019.00030.3.

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Yasmeen, Sonia, Zahoor Ahmad, and Nadia Ishtiaq. "The Comparative Effects of Butler’s Neural Tissue Mobilization and Mulligan’s Bent Leg Raise in Patients with Chronic Lumbar Radiculopathy." Journal Riphah College of Rehabilitation Sciences 10, no. 02 (2022): 90–96. http://dx.doi.org/10.53389/jrcrs.2022100207.

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31

Lu, C. Z., and B. G. Xiao. "G-CSF and neuroprotection: a therapeutic perspective in cerebral ischaemia." Biochemical Society Transactions 34, no. 6 (2006): 1327–33. http://dx.doi.org/10.1042/bst0341327.

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In several experimental studies of cerebral ischaemia, G-CSF (granulocyte colony-stimulating factor) exerted neuroprotective effects through different mechanisms, including mobilization of haemopoietic stem cells, anti-apoptosis, neuronal differentiation, angiogenesis and anti-inflammation. Hence, G-CSF not only inhibits neuron death, but also generates ‘new’ neural tissue formation. A small pilot trial reports on the safety and feasibility of G-CSF therapy in stroke patients. According to this evidence, we can speculate that G-CSF, being used either alone or in combination with another agent,
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Cowley, Kristine C. "A new conceptual framework for the integrated neural control of locomotor and sympathetic function: implications for exercise after spinal cord injury." Applied Physiology, Nutrition, and Metabolism 43, no. 11 (2018): 1140–50. http://dx.doi.org/10.1139/apnm-2018-0310.

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All mammals, including humans, are designed to produce sustained locomotor movements. Many higher centres are involved in movement, but ultimately these centres act upon a core “rhythm-generating” network within the brainstem-spinal cord. In addition, endurance-based locomotor exercise requires sympathetic neural support to maintain homeostasis and to provide needed metabolic resources. This review focuses on the roles and integration of these 2 neural systems. Part I reviews the cardiovascular, thermoregulatory, and metabolic functions under spinal sympathetic control as revealed by spinal co
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Pascual-Guerra, J., M. Torres-Rico, B. Marín-Rodríguez, et al. "Repurposed Drugs to Enhance the Therapeutic Potential of Oligodendrocyte Precursor Cells Derived from Adult Rat Adipose Tissue." Cells 14, no. 7 (2025): 533. https://doi.org/10.3390/cells14070533.

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Failure in the proliferation, recruitment, mobilization, and/or differentiation of oligodendrocyte precursor cells (OPCs) impedes remyelination in central nervous system (CNS) demyelinating diseases. Our group has recently achieved the generation of functional oligodendroglia through direct lineage conversion by expressing Sox10, Olig2, and Zfp536 genes in adult rat adipose tissue-derived stromal cells. The present study aimed to determine whether various repurposed drugs or molecules could enhance the myelinating capacities of these induced OPCs (iOPCs). We report that kainate, benztropine, m
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Ferragut-Garcías, Alejandro, Gustavo Plaza-Manzano, Cleofás Rodríguez-Blanco, et al. "Effectiveness of a Treatment Involving Soft Tissue Techniques and/or Neural Mobilization Techniques in the Management of Tension-Type Headache." Archives of Physical Medicine and Rehabilitation 98, no. 2 (2017): 211–19. http://dx.doi.org/10.1016/j.apmr.2016.08.466.

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Chandan, Sunnia, Siddhartha Sen, and Umer Arfath. "Effect of Cervical Lateral Glide over Neural Tissue Mobilization for Median Nerve In Case Of Patients with Cervico-Brachial Pain Syndrome." International Journal of Health and Rehabilitation Sciences (IJHRS) 4, no. 1 (2015): 37. http://dx.doi.org/10.5455/ijhrs.000000076.

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Shahriary, Ghazaleh M., Hardeep Kataria, and Soheila Karimi-Abdolrezaee. "Neuregulin-1 Fosters Supportive Interactions between Microglia and Neural Stem/Progenitor Cells." Stem Cells International 2019 (April 7, 2019): 1–20. http://dx.doi.org/10.1155/2019/8397158.

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Microglia play diverse roles in homeostasis and pathology of the central nervous system (CNS). Their response to injury or insult is critical for initiating neuroinflammation and tissue damage as well as resolution of inflammation and wound healing. Changes to the microenvironment of microglia appear to be a key determinant of their phenotype and their role in the endogenous repair process in the injured or diseased CNS. Our recent findings have identified a positive role for neuregulin-1 (Nrg-1) in regulating immune response in spinal cord injury and focal demyelinating lesions. We show that
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Zhu, Liu, Glazier, et al. "Differential Sympathetic Activation of Adipose Tissues by Brain-Derived Neurotrophic Factor." Biomolecules 9, no. 9 (2019): 452. http://dx.doi.org/10.3390/biom9090452.

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Centrally administered brain-derived neurotrophic factor (BDNF) decreases body adiposity beyond what can be accounted for by decreased food intake, implying enhanced lipid metabolism by BDNF. Consistent with this notion, intracerebroventricular (icv) injection of BDNF in rats increased the expression of lipolytic enzymes in white adipose tissues (WAT) and increased circulating concentrations of lipolytic products without changing the levels of adrenal gland hormones. This suggests that central BDNF-induced lipid mobilization is likely due to sympathetic neural activation, rather than activatio
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Kucia, Magda, Zhang Y. Ping, Janina Ratajczak, Suzanne T. Ildstad, Chris Shields, and Mariusz Z. Ratajczak. "Evidence That CXCR4+ Neural Tissue-Committed Stem Cells (TCSC) Reside/Hide out in the Bone Marrow and Are Mobilized into the Peripheral Blood during Stroke." Blood 104, no. 11 (2004): 2698. http://dx.doi.org/10.1182/blood.v104.11.2698.2698.

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Abstract Several recent studies in animals as well as humans support the notion that bone marrow (BM)-derived cells participate in brain regeneration. However, the identity of the specific cell type responsible for regeneration remains unknown. Recent work from our laboratory revealed that BM contains a highly mobile population of CXCR4+ cells that express mRNA for various markers of early tissue-committed stem cells (TCSC) and which are distinct from hematopoietic stem cells (HSC) (Leukemia2004:18;29–40). In this study we investigated whether BM also contains a mobile pool of TCSC destined to
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Song, C. Kay, Cheryl H. Vaughan, Erin Keen-Rhinehart, Ruth B. S. Harris, Denis Richard, and Timothy J. Bartness. "Melanocortin-4 receptor mRNA expressed in sympathetic outflow neurons to brown adipose tissue: neuroanatomical and functional evidence." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 295, no. 2 (2008): R417—R428. http://dx.doi.org/10.1152/ajpregu.00174.2008.

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A precise understanding of neural circuits controlling lipid mobilization and thermogenesis remains to be determined. We have been studying the sympathetic nervous system (SNS) contributions to white adipose tissue (WAT) lipolysis largely in Siberian hamsters. Central melanocortins are implicated in the control of the sympathetic outflow to WAT, and, moreover, the melanocortin 4 receptors (MC4-R) appear to be principally involved. We previously found that acute third ventricular melanotan II (MTII; an MC3/4-R agonist) injections increase sympathetic drive (norepinephrine turnover) to interscap
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Lindenmann, J., L. Kamolz, W. Graier, J. Smolle, and F. M. Smolle-Juettner. "Hyperbaric Oxygen Therapy and Tissue Regeneration: A Literature Survey." Biomedicines 10, no. 12 (2022): 3145. http://dx.doi.org/10.3390/biomedicines10123145.

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By addressing the mechanisms involved in transcription, signaling, stress reaction, apoptosis and cell-death, cellular structure and cell-to-cell contacts, adhesion, migration as well as inflammation; HBO upregulates processes involved in repair while mechanisms perpetuating tissue damage are downregulated. Many experimental and clinical studies, respectively, cover wound healing, regeneration of neural tissue, of bone and cartilage, muscle, and cardiac tissue as well as intestinal barrier function. Following acute injury or in chronic healing problems HBO modulates proteins or molecules invol
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Tambekar, Neha, Shaila Sabnis, Apoorva Phadke, and Nilima Bedekar. "Effect of Butler's neural tissue mobilization and Mulligan's bent leg raise on pain and straight leg raise in patients of low back ache." Journal of Bodywork and Movement Therapies 20, no. 2 (2016): 280–85. http://dx.doi.org/10.1016/j.jbmt.2015.08.003.

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Nageswari, C., Dr N. Meena, and Dr T. Ramani Devi. "A Non Invasive Approach to Prevent Carpel Tunnel Syndrome of IT Women during Pregnancy." YMER Digital 21, no. 02 (2022): 532–45. http://dx.doi.org/10.37896/ymer21.02/52.

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Carpal Tunnel Syndrome results in considerable discomfort and pain, limitation of activities of daily living, loss of sleep and work disability. Carpal tunnel Syndrome is more frequent in pregnancy because the systemic process increases the extra capsular fluid retention by the hormone Prolactin and produce soft tissue swelling in the later stages (third trimester) of their pregnancies. Many therapies have been advocated for treating the carpal tunnel syndrome including Mobilizations, nerve gliding, tendon gliding, Ultrasound, icing, Massaging, Elevating the arm or flicking, Neural mobilizatio
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Song, C. Kay, Gary J. Schwartz, and Timothy J. Bartness. "Anterograde transneuronal viral tract tracing reveals central sensory circuits from white adipose tissue." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 296, no. 3 (2009): R501—R511. http://dx.doi.org/10.1152/ajpregu.90786.2008.

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The origins of the sympathetic nervous system (SNS) innervation of white adipose tissue (WAT) have been defined using the transneuronal viral retrograde tract tracer, pseudorabies virus. Activation of this SNS innervation is acknowledged as the principal initiator of WAT lipolysis. The central control of WAT lipolysis may require neural feedback to a brain-SNS-WAT circuit via WAT afferents. Indeed, conventional tract tracing studies have demonstrated that peripheral pseudounipolar dorsal root ganglion (DRG) sensory cells innervate WAT. The central nervous system projections of WAT afferents re
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Szikszay, T. "Effectiveness of a Treatment Involving Soft Tissue Techniques and/or Neural Mobilization Techniques in the Management of Tension-Type Headache: A Randomized Controlled Trial." physioscience 13, no. 04 (2017): 186–87. http://dx.doi.org/10.1055/s-0035-1567230.

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Jain, Muskan, Manish Kumar Jha, and Vamakshi Vijay. "Study the Immediate Effects of “Primal Reflex Release Technique™” Versus “Neural Tissue Mobilization” on Hip Flexor Tightness in Individuals with a Sedentary Lifestyle." International Journal of Physiotherapy and Research 12, no. 5 (2024): 4798–805. http://dx.doi.org/10.16965/ijpr.2024.134.

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Background: An inactive life can lead to various problems, such as tightness of muscles, decreased joint mobility, and decreased pliability, which can hinder daily activities. Prolonged sitting puts a lot of force on the muscles, increasing the risk of injury. Studies have shown that many people with desk jobs have tight iliopsoas muscles, resulting in lower strength, restricted hip movement, increased pelvic tilt, and excessive lower back curvature. Objective: This study investigates the immediate effectiveness of PRRT™ and NTM on hip flexor tightness in individuals with a sedentary lifestyle
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Sinha, Sanjiv, Anil Kumar Singh, Vikas Gupta, Daljit Singh, Masakazu Takayasu, and Jun Yoshida. "Surgical Management and Outcome of Tuberculous Atlantoaxial Dislocation: A 15-year Experience." Neurosurgery 52, no. 2 (2003): 331–39. http://dx.doi.org/10.1227/01.neu.0000043930.28934.fe.

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Abstract OBJECTIVE Tuberculous atlantoaxial dislocation is a rare disease entity. However, tuberculosis continues to be endemic in developing countries. Its earliest clinical presentation may be nonspecific, and delay in diagnosis may lead to irreversible neurological deficit. The management of tuberculous atlantoaxial dislocation includes ventral cervicomedullary decompression, occipitocervical arthrodesis, and administration of antituberculous medications. METHODS Eighteen patients with tuberculous atlantoaxial dislocation who presented with neck pain and/or occipital headache, restriction o
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Gonzalo-Gobernado, Rafael, Diana Reimers, Antonio S. Herranz, et al. "Mobilization of Neural Stem Cells and Generation of New Neurons in 6-OHDA–lesioned Rats by Intracerebroventricular Infusion of Liver Growth Factor." Journal of Histochemistry & Cytochemistry 57, no. 5 (2009): 491–502. http://dx.doi.org/10.1369/jhc.2009.952275.

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Neural stem cells with self-renewal and multilineage potential persist in the subventricular zone of the adult mammalian forebrain. These cells remain relatively quiescent but, under certain conditions, can be stimulated, giving rise to new neurons. Liver growth factor (LGF) is a mitogen for liver cells that shows biological activity in extrahepatic sites and is useful for neuroregenerative therapies. The aim of this study was to investigate the potential neurogenic activity of LGF in the 6-hydroxydopamine rat model of Parkinson's disease. Proliferation was significantly increased in the subve
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Prasad, Gungi Raghavendra, Deepak Sharma, J. V. Subba Rao, P. Siva Kumar, and Amtul Aziz. "Lumbodorsal flap for repair of meningomyelocele- a procedure matched controlled study." International Surgery Journal 4, no. 5 (2017): 1678. http://dx.doi.org/10.18203/2349-2902.isj20171620.

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Background: Open neural tube defects have been approached by innumerable surgical techniques. Hitherto, excision of the exposed neural tube component, water tight closure of dura, approximation of paraspinal soft tissue and skin closure repair was stressed. Support of vertebral defect was not adequately addressed. Objectives were to introduce lumbodorsal/thoraco dorsal fascial flap as an effective answer to the vertebral defect component of MMC. To compare conventional paraspinal soft tissue closure with lumbodorsal/ thoracodorsal fascial flap.Methods: This was a procedure matched controlled s
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Lebeau, Grégorie, Franck Ah-Pine, Matthieu Daniel, et al. "Perivascular Mesenchymal Stem/Stromal Cells, an Immune Privileged Niche for Viruses?" International Journal of Molecular Sciences 23, no. 14 (2022): 8038. http://dx.doi.org/10.3390/ijms23148038.

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Mesenchymal stem cells (MSCs) play a critical role in response to stress such as infection. They initiate the removal of cell debris, exert major immunoregulatory activities, control pathogens, and lead to a remodeling/scarring phase. Thus, host-derived ‘danger’ factors released from damaged/infected cells (called alarmins, e.g., HMGB1, ATP, DNA) as well as pathogen-associated molecular patterns (LPS, single strand RNA) can activate MSCs located in the parenchyma and around vessels to upregulate the expression of growth factors and chemoattractant molecules that influence immune cell recruitme
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Ruby Dhar, Arun Kumar, and Subhradip Karmakar. "Acoustic therapy: New paradigms." Asian Journal of Medical Sciences 16, no. 4 (2025): 1–2. https://doi.org/10.71152/ajms.v16i4.4489.

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The medical field seldom considers sound prescriptions as effective healing methods. Nevertheless, the awareness of this technology and its potential to address certain ailments has existed for many years. Sound-based medical therapy encompasses diverse therapeutic approaches that utilize acoustic waves and vibrations to treat various conditions. Here is an overview of this fascinating field. The current sound-based medical therapies include the following:1. Ultrasound therapya. High-intensity focused ultrasound for non-invasive tumor ablationb. Low-intensity pulsed ultrasound for bone fractur
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