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Dissertations / Theses on the topic 'NEUROBLASTOMA HUMANO (SH-SY5Y)'

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Published: 18 April 2022

Last updated: 30 July 2025

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1

Desales, Salazar Erasto. "EVALUACIÓN DEL EFECTO DEL GEN CII-6 DEL ALACRÁN Centruroides limpidus EN CÉLULAS DE NEUROBLASTOMA HUMANO (SH-SY5Y)." Tesis de maestría, Universidad Autónoma del Estado de México, 2021. http://hdl.handle.net/20.500.11799/112132.

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Tesis de grado de maestría del programa de Maestría en Ciencias Agropecuarias y Recursos Naturales de la UAEM, dentro de la linea de investigación de biotecnología.<br>Durante los últimos años el cáncer y sus diversos tipos han surgido como una de las principales causas de mortalidad en el mundo, de acuerdo con las recientes estadísticas del Global Burden of Disease Cancer Collaboration, en 2017, hubo 24.5 millones de incidencias de cáncer en todo el mundo, de las cuales 9.6 millones se traducen en muertes causadas por el mismo (Fitzmaurice et al., 2019); Aunado a esto, hay evidencia de que en

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2

Medeiros, Liana Marengo de. "Diferenciação colinérgica da linhagem de neuroblastoma humano SH-SY5Y e seu uso como modelo in vitro da Doença de Alzheimer." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/126841.

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A Doença de Alzheimer (DA) é uma desordem neurodegenerativa caracterizada por um declínio cognitivo global, incluindo uma perda progressiva de memória, orientação e raciocínio, associada com a degeneração especifica de neurônios colinérgicos. As alterações histopatológicas que definem a DA são protéicos de β-amilóide e tau hiperfosforilada em placas senis e emaranhados neurofibrilares, respectivamente. Porém, os mecanismos moleculares que levam a DA não estão bem caracterizados e ainda não há nenhum tratamento eficaz para prevenir ou reverter os seus sintomas. Parte dessa dificuldade se deve à

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López, Carballo Gracia Mª. "Caracterización de genes regulados por el ácido retinoico implicados en la diferenciación celular de células SH-SY5Y de neuroblastoma humano." Doctoral thesis, Universitat de València, 2002. http://hdl.handle.net/10803/10017.

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Las señales mediadas por los Receptores Nucleares de Hormonas desempeñan un importante papel en el control de la diferenciación celular. El objetivo de este trabajo es analizar los mecanismos moleculares a través de los cuales se ejerce este control. Como sistema experimental utilizamos células de neuroblastoma humano SH-SY5Y, cuya diferenciación se induce mediante tratamiento con ácido retinoico (RA) que produce la parada en el crecimiento y desencadena la diferenciación celular. Estudiar el mecanismo molecular a través del cual, actúa el RA, también resulta interesante desde un punto de vist

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4

Rabie, Soheyla Mohd Souza. "Avaliação das propriedades redox-ativas e citotóxicas ou citoprotetoras do carvacrol em cultura de células de neuroblastoma humano SH-SY5Y." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2013. http://hdl.handle.net/10183/77086.

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Espécies reativas de oxigênio (ERO) são produzidas através da respiração aeróbica e durante processos inflamatórios. Além disso, agressões externas como radiações, poluição, estresse, alcoolismo e tabagismo aumentam a sua produção. Altos níveis de ERO podem ocasionar dano oxidativo à lipídios, proteínas e DNA, comprometendo a função normal da célula, podendo estar envolvidos na patogênese e agravamento de diversas doenças. Há evidências que sugerem que antioxidantes naturais presentes em alimentos conferem benefícios adicionais à saúde, atuando como anticarcinogênicos, antiinflamatórios ou age

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Pinheiro, Nathalia Réges. "Estudo comparativo da neuroproteção por anticorpos anti-A? contra a toxicidade de oligômeros de A? em cultura diferenciada de neuroblastoma humano." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17131/tde-25042018-112913/.

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A Doença de Alzheimer (DA) é a principal causa de demência na população idosa e tende a se tornar um grave problema de saúde pública com o aumento da expectativa de vida da população mundial. A perda progressiva de memória, principal sintoma da demência em pacientes com DA, é atribuída a danos sinápticos e à perda neuronal desencadeadas pelo desequilíbrio entre a produção e a depuração do peptídeo A?. Evidências surgidas nos últimos 20 anos apontam os oligômeros solúveis de A? (A?O), produtos de agregação do peptídeo A?, como as principais espécies neurotóxicas na DA. Por conta disso, e também

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6

Londero, Giovana Ferreira. "Neuropatia diabética : estudo dos mecanismos moleculares envolvidos com a neurotoxicidade do metilglioxal e do glicolaldeído em células diferenciadas de neuroblastoma humano SH-SY5Y." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/66079.

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Neuropatia é a complicação mais comum e mais debilitante da Diabetes Mellitus, a longo prazo presente em mais de 50% dos pacientes que possuem a doença. A hiperglicemia induz estresse oxidativo nos neurônios de diabéticos acarretando a ativação de múltiplas vias bioquímicas, as quais são potenciais alvos terapêuticos para a neuropatia diabética. Está claro que compostos carbonil reativos são mediadores glicotóxicos do estresse oxidativo através da formação de produtos finais de glicação avançada como resultado direto da hiperglicemia. Metilglioxal e glicolaldeído são compostos carbonil reativo

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7

Peres, Tanara Vieira. "Avaliação da neurotoxicidade do manganês em modelos in vitro de fatias estriatais e hipocampais de ratos e células de neuroblastoma humano SH-SY5Y." reponame:Repositório Institucional da UFSC, 2012. http://repositorio.ufsc.br/xmlui/handle/123456789/95786.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Bioquímica, Florianópolis, 2011<br>Made available in DSpace on 2012-10-26T05:55:49Z (GMT). No. of bitstreams: 1 290493.pdf: 1377229 bytes, checksum: f31b828d766c78322c4be4d70267bb08 (MD5)<br>A contaminação ambiental por metais é um fator de risco para a saúde pública, sendo o sistema nervoso central (SNC) um importante alvo desses compostos. Exposição excessiva ao manganês (Mn2+) pode causar uma síndrome semelhante ao Parkinson, com perda de neurônios dopaminérgicos, cha

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8

Querobino, Samyr Machado. "Efeitos neuroprotetores dos peptídeos potencializadores de bradicinina do veneno da serpente bothrops jararaca sob o estresse oxidativo em cultura de neuroblastoma humano sh-sy5y." reponame:Repositório Institucional da UFABC, 2018.

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Orientador: Prof. Dr. Carlos Alberto-Silva<br>Tese (doutorado) - Universidade Federal do ABC, Programa de Pós-Graduação em Neurociência e Cognição, Santo André, 2018.<br>Os Peptídeos Potenciadores de Bradicinina (BPPs) são oligopeptídeos presentes na fração de baixo peso molecular (FBP) do veneno da serpente Bothrops jararaca (Bj). Estes peptídeos são descritos como inibidores naturais da Enzima Conversora de Angiotensina. Porém, eles também alteram a atividade catalítica e a expressão da argininosuccinato sintetase (AsS), favorecendo a síntese de Larginina. Este aminoácido participa de várias

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9

Lopes, Fernanda Martins. "Caracterização da diferenciação neural induzida por ácido retinóico da linhagem de neuroblastoma humano SH-SY5Y e seu uso como ferramenta para pesquisa em neurociências." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/49007.

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Os mecanismos moleculares que levam ao dano da via nigroestriatal durante a progressão da Doença de Parkinson (DP) ainda não estão totalmente elucidados. Dessa forma, existe a necessidade de desenvolver modelos experimentais adequados para o estudo desse distúrbio neurodegenerativo. A linhagem de neuroblastoma humano SH-SY5Y tratada com neurotoxinas indutoras deste distúrbio (ex.: 6-hidroxidopamina - 6-OHDA) é amplamente utilizada como modelo in vitro da DP. Muitos estudos mostram que esta linhagem pode ser diferenciada em células dopaminérgicas através da combinação da diminuição do soro feta

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10

Olsson, Anna-Karin. "Ras-MAPK signaling in differentiating SH-SY5Y human neuroblastoma cells." Doctoral thesis, Uppsala University, Department of Genetics and Pathology, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1251.

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<p>Neuroblastoma is a malignant childhood cancer, originating from sympathetic neuroblasts of the peripheral nervous system. Neuroblastoma is a heterogenous group of tumours, while some are highly malignant others can spontaneosly mature into a more benign form or regress. Less than half of the patients survive and this statistics has improved only modestly over the past 20 years. </p><p>SH-SY5Y is a human neuroblastoma cell line established from a highly malignant tumour. The cells have retained a capacity to differentiate <i>in vitro</i> in response to low concentrations of the phorbolester

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11

Al-Jarari, Nouh Mohamed Hamed. "Regulation of adenosine receptors in human SH-SY5Y neuroblastoma cells." Thesis, University of Nottingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.438430.

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12

Riddoch, Fiona C. "CaÂ²âº signaling in human neuroblastoma SH-SY5Y cells." Thesis, University of Newcastle Upon Tyne, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416990.

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13

Yamakawa, Kentaro. "Dopamine facilitates α-synuclein oligomerization in human neuroblastoma SH-SY5Y cells". Kyoto University, 2010. http://hdl.handle.net/2433/120568.

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14

Fjæraa, Alfredsson Christina. "Effects of ellagic acid in human neuroblastoma cells." Doctoral thesis, Karlstads universitet, Institutionen för hälsovetenskaper, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-29905.

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A diet rich in polyphenols has been proposed to have beneficial health effects and to reduce risk of disease. Ellagic acid, a polyphenol common in red berries and pomegranates, has potential anti-tumorigenic effects that make it interesting to further study in different cancer cell systems. Neuroblastoma is a childhood cancer that arises during development of the peripheral nervous system. Neuroblastoma, being an embryonal tumor, show loss of function of genes controlling differentiation and apoptosis. Neuroblastoma is a heterogenic tumor disease, and highly malignant neuroblastomas are diffic

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15

Belbaraka, Loubaba. "Growth, differentiation and cell-cell coupling in the human neuroblastoma cell line SH-SY5Y." Thesis, University of Ottawa (Canada), 2002. http://hdl.handle.net/10393/6112.

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Neuroblastoma is one of the most common paediatric solid tumours, frequently occurring in infancy with the primary lesion in the adrenal gland and sympathetic nervous system. It originates from primitive neural crest cells. In rare cases, this tumour regresses spontaneously to a more benign ganglioneuroma probably by neuronal differentiation or apoptosis. We investigated the role of induction of neuronal differentiation and apoptosis in vitro in SH-SY5Y neuroblastoma cells. A variety of agents that are known to induce neuronal differentiation including retinoic acid, nerve growth factor (NGF),

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Sharma, Mohit Kumar. "Analysis of the effects of incretin-based peptides on human neuroblastoma SH-SY5Y cells." Thesis, Ulster University, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.673817.

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Incretins are growth factors that have demonstrated neuroprotective properties in a range of studies. Here, we analyse the neuroprotective properties of the Glucagon like peptide-l (GLP-l) analogues in human neuroblastoma SH-SY5Y cells against methyl glyoxal (MG) stress. The results demonstrate a range of growth factor-related cytoprotective processes induced by liraglutide (Victoza®), currently used to treat type 2 diabetes. FUl1her, we study the comparative long-term effects of three different GLP-l analogues on cell viability, proliferation and cytotoxicity and demonstrate the long-term exp

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Lau, Kwok-wai. "Evaluation of using all-trans-retinoic acid to differentiate human neuroblastoma SH-SY5Y cells in neurodegeneration research." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39557339.

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Lau, Kwok-wai, and 劉國威. "Evaluation of using all-trans-retinoic acid to differentiate human neuroblastoma SH-SY5Y cells in neurodegeneration research." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39557339.

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19

Klein, Juliane. "Amyloid precursor protein (APP) and copper homeostasis in the human neuroblastoma cell line SH-SY5Y." Thesis, University of Newcastle upon Tyne, 2011. http://hdl.handle.net/10443/1201.

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Alzheimer’s disease (AD) is characterised by cerebellar accumulation and aggregation of amyloid beta (Aβ), a cleavage product of the transmembrane amyloid precursor protein (APP). APP contains a range of functional domains in its large extracellular portion, among which are two copper-binding motifs and one zinc-binding motif. The copper-binding motifs are present in the amino-terminal region of APP and within the Aβ region of the protein and readily reduce Cu(II) to Cu(I), thus APP and its cleavage products are linked to copper metabolism and have been hypothesised to participate in cellular

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20

Song, Xiaoou. "A study of the neurotoxicity of MPTP and analogs in human neuroblastoma SH-SY5Y cells." Diss., This resource online, 1996. http://scholar.lib.vt.edu/theses/available/etd-08082007-120224/.

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21

Manning, Alicia. "Profiling biochemical changes associated with retinoic acid-induced differentiation of SH-SY5Y human neuroblastoma cells." Thesis, Manning, Alicia (2015) Profiling biochemical changes associated with retinoic acid-induced differentiation of SH-SY5Y human neuroblastoma cells. Honours thesis, Murdoch University, 2015. https://researchrepository.murdoch.edu.au/id/eprint/29631/.

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SH-SY5Y neuroblastoma cells have been widely used in neuroscience research to model neurotoxic processes. It is unclear how well, in their undifferentiated, immortalised state, the cells model the original tissue type. SH-SY5Y cells can be differentiated, with compounds such as retinoic acid (RA), to become more ‘tissue-like’, and potentially better reflect the biochemistry of a mature neuronal cell. Studies that have investigated the RA-induced differentiation process have focused on upstream changes associated with a small number of genes or proteins. This study proposed to use a novel appro

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22

Yang, Wonsuk. "The bipyridyl herbicide paraquat-induced toxicity in human neuroblastoma SH-SY5Y cells: relevance to dopaminergic pathogenesis." Texas A&M University, 2005. http://hdl.handle.net/1969.1/4384.

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Paraquat (PQ) is a cationic non-selective bipyridyl herbicide widely used in agriculture to control weeds and grasses. Epidemiologic studies indicate that exposure to pesticides can be a risk factor in the incidence of Parkinson`s disease (PD). A strong correlation has been reported between exposure to paraquat and PD incidence in Canada, Taiwan, and United States. This correlation is supported by animal studies showing that paraquat produces toxicity in dopaminergic neurons of the rat and mouse brain. However, it is unclear how paraquat triggers toxicity in dopaminergic neurons. Based on the

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23

Hynds, DiAnna Lynn. "Molecular mechanisms of ganglioside inhibition of proliferation and neurite outgrowth in sh-sy5y human neuroblastoma cells /." The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487948158628685.

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Moulédous, Lionel Dossin Olivier. "Effets d'un traitement chronique par la morphine sur le protéome des cellules de neuroblastome humain SH-SY5Y." [S.l.] : [s.n.], 2007. http://oatao.univ-toulouse.fr/1794/1/debouch_1794.pdf.

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25

Tieu, Kim. "Involvement of bcl-2 and p53 genes in the survival of human catecholaminergic neuroblastoma SH-SY5Y cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/NQ63933.pdf.

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26

Graça, Júlio César Gomes. "Avaliação dos efeitos de acetato em células de neuroblastoma SH-SY5Y e células-tronco humanas de dente decíduo esfoliado cultivadas na presença de glutamato." Universidade Federal de Juiz de Fora (UFJF), 2017. https://repositorio.ufjf.br/jspui/handle/ufjf/5829.

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Submitted by Renata Lopes (renatasil82@gmail.com) on 2017-09-28T12:03:28Z No. of bitstreams: 1 juliocesargomesgraca.pdf: 1848019 bytes, checksum: f98e75e5c5ca605913fabb43b02b8b5b (MD5)<br>Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2017-09-28T14:14:08Z (GMT) No. of bitstreams: 1 juliocesargomesgraca.pdf: 1848019 bytes, checksum: f98e75e5c5ca605913fabb43b02b8b5b (MD5)<br>Made available in DSpace on 2017-09-28T14:14:08Z (GMT). No. of bitstreams: 1 juliocesargomesgraca.pdf: 1848019 bytes, checksum: f98e75e5c5ca605913fabb43b02b8b5b (MD5) Previous issue d

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Neasta, Jérémie. "Effet d'un traitement à la morphine sur le protéome des cellules de neuroblastome humain SH-SY5Y." Phd thesis, Université Paul Sabatier - Toulouse III, 2006. http://tel.archives-ouvertes.fr/tel-00137683.

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En France la prise en charge des grandes douleurs fait toute sa place à la morphine. Cependant la prise prolongée de morphine entraîne la tolérance et la dépendance. Une stratégie de protéomique différentielle a été entreprise afin d'identifier les adaptations cellulaires à un traitement par la drogue dans des cellules SH-SY5Y. Nous avons montré, notamment, qu'un traitement chronique entraîne la dégradation par le protéasome des protéines Gbeta et Ggamma2. Aussi, le niveau de dégradation de Gbeta est corrélé avec le niveau de sensibilisation de l'adénylyl cyclase (AC), phénomène impliqué dans

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Neasta, Jérémie. "Effet d’un traitement à la morphine sur le protéome de cellules de neuroblastome humain SH-SY5Y." Toulouse 3, 2006. http://www.theses.fr/2006TOU30147.

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En France la prise en charge des grandes douleurs fait toute sa place à la morphine. Cependant la prise prolongée de morphine entraîne la tolérance et la dépendance. Une stratégie de protéomique différentielle a été entreprise afin d’identifier les adaptations cellulaires à un traitement par la drogue dans des cellules SH-SY5Y. Nous avons montré, notamment, qu’un traitement chronique entraîne la dégradation par le protéasome des protéines Gbeta et Ggamma2. Aussi, le niveau de dégradation de Gbeta est corrélé avec le niveau de sensibilisation de l’adénylyl cyclase (AC), phénomène impliqué dans

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Smith, Ian Francis. "Hypoxia and amyloid β peptide modulation of Ca²₊ signaling in the human neuroblastoma SH-SY5Y and rat type I cortical astrocytes". Thesis, University of Leeds, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270674.

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Wheldon, Lee Mark. "A comparative study of phosphoinositide and calcium signalling by G-protein-coupled receptors and growth factor receptors in human SH-SY5Y neuroblastoma cells." Thesis, University of Leicester, 2001. http://hdl.handle.net/2381/29930.

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This study investigated G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK)-mediated signal transduction via phospholipase C (PLC). A transient elevation of intracellular [Ca2+] ([Ca2+]i) was identified in response to PDGF-BB. Despite the recruitment and phosphorylation of PLC-, the mechanism was apparently novel and Ins(1,4,5)P3-independent. Muscarinic M3 receptor-dependent Ins(1.4.5)P3 and Ca2+ signalling was biphasic, consisting of a peak and plateau. Both agonist-occupied receptors relied on capacitative Ca2+ influx triggered by intracellular Ca2+ store release for maximum

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Guidi, Mònica. "Micro RNA-Mediated regulation of the full-length and truncated isoforms of human neurotrophic tyrosine kinase receptor type 3 (NTRK 3)." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7114.

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Neurotrophins and their receptors are key molecules in the development of the<br/>nervous system. Neurotrophin-3 binds preferentially to its high-affinity receptor<br/>NTRK3, which exists in two major isoforms in humans, the full-length kinaseactive<br/>form (150 kDa) and a truncated non-catalytic form (50 kDa). The two<br/>variants show different 3'UTR regions, indicating that they might be differentially<br/>regulated at the post-transcriptional level. In this work we explore how<br/>microRNAs take part in the regulation of full-length and truncated NTRK3,<br/>demonstrating that the two isof

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Khosasih, Vivia. "The cytotoxic effect of THJ-018 in human neuroblastoma SH-SY5Y cells." Master's thesis, 2016. http://hdl.handle.net/10400.26/19081.

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Dissertação de Erasmus Mundus para obtenção do grau de mestre em Técnicas Laboratoriais Forenses<br>Since its first appearing on 2004, synthetic cannabinoidsm the market of the so-called recreational drug, have regained popularity among adolescents and young adults. Current in vitro studies show that synthetic cannabinoids have stringer binding affinity to cannabinoids 1 (CB1) receptor than the Δ9-tetrahydrocannabinal. Therefore, it suggested that synthetic cannabinoids possess stronger psychotropic effect than cannabis. Albeit it has been increasingly abused as the legal alternative of cannab

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Kao, Tzu-Wen, and 高子文. "Effects of mercuric chloride-induced oxidative stress on SH-SY5Y human neuroblastoma cells." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/42878018396885862830.

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Wu, Chi-Wei, and 吳志瑋. "Effects of Methamphetamine on Mitochondrial Function and Cell Growth in Human Neuroblastoma SH-SY5Y Cells." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/18088895861325086847.

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碩士<br>國立陽明大學<br>藥理學研究所<br>93<br>In Taiwan, methamphetamine (METH) is a wildly abused drug, which was originally used as a psychostimulant. Several studies have demonstrated that METH would cause neurotoxicity and damage neuronal cells in rat brain. In addition, METH would lead to neurodegeneration and cause a loss of neuronal function. Up to now, the cellular and molecular mechanisms of METH-induced damage still remain unclear, but the generally-accepted concept is that reactive oxygen species (ROS) play an important role in the process of METH-induced neurodegeneration. Mitochondria are the m

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"Regulation ofmu opiate receptors by endomorphin-1 and morphine in SH-SY5Y human neuroblastoma cells." Tulane University, 2002.

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The human neuroblastoma cell line, SH-SY5Y, was used to determine to examine the effects of the endogenous opioid peptides, endomorphin-1 and endomorphin-2, and the plant-derived alkaloid, morphine on mu opiate receptors. Chronic exposure to endomorphin-1, endomorphin-2 and morphine resulted in over a 50% reduction in total receptor number, without affecting the affinity of 3H-DAMGO for mu opiate receptors in SH-SY5Y cells. There was no significant difference in the reduction in receptor number between the three agonists. EM-1, EM-2 and morphine treatment for 24h at 100nM 1muM and 10muM doses

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"Low dose methylmercury-induced oxidative stress, cytotoxicity and tau-hyperphosphorylation in human neuroblastoma (SH-Sy5y) cells." Tulane University, 2011.

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Acute neurotoxic effects of high dose methylmercury (MeHg) in humans have been well documented in the scientific literature. However, low dose effects are less well described. This study was designed to evaluate the effects of low dose MeHg (<100 nM) on human brain cells in a tissue culture model. Neuroblastoma cells (SH-Sy5y) were used in the cell culture model to study low dose effects of MeHg on cell growth, cell survival, oxidative stress and the phosphorylation of tau protein, as a measure of potential markers of cellular events associated with tauopathies. When cells were incubated in cu

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Desai, Anu. "Human neuroblastoma (SH-SY5Y) cell culture and differentiation in 3-D collagen hydrogels for cell-based biosensing." 2004. http://purl.galileo.usg.edu/uga%5Fetd/desai%5Fanu%5Fa%5F200412%5Fms.

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Chen, Meng-Ling, and 陳孟伶. "Effects of amphetamine on nicotinic acetylcholine receptor in bovine adrenal chromaffin cells and human neuroblastoma SH-SY5Y." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/55951316112270396175.

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碩士<br>東吳大學<br>微生物學系<br>91<br>Amphetamine, a potent psychostimulant of abuse, is known as to release dopamine through its actions at dopamine transporters. In addition to dopamine transporters, we previously found that amphetamine acted at nicotinic acetylcholine receptor (nAChR) to induce cytosolic free calcium ion concentration ([Ca2+]c) rise alone and to inhibit the catecholamine secretion and [Ca2+]c rise coupled with nAChR in bovine adrenal chromaffin cells. In this study, the acute and chronic effects of amphetamine were investigated in bovine chromaffin cells and human neuroblastoma SH-S

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Chang, Chia-Yu, and 張家瑜. "Molecular Mechanism of Methamphetamine-induced Mitochondrial Alterations, Oxidative Stress, and Cytoxicity in Human Neuroblastoma SH-SY5Y Cells." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/40015208043001242661.

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碩士<br>國立陽明大學<br>藥理學研究所<br>94<br>Methamphetamine (METH) is a widely abused drug, which is originally used as a psychostimulant. It has been reported that METH can induce neurotoxicity and neurodegeneration in animal brain. Nevertheless, the molecular and cellular mechanisms by which METH induces neurotoxicity remain unclear. In a previous study, it was found that 250 μg/mL of METH induced mitochondrial membrane potential loss, reactive oxygen species (ROS) production, mitochondrial mass increase, cell viability decrease in human neuroblastoma SH-SY5Y cells. In this study, I further demonstrated

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Lin, Fang-yu, and 林芳瑜. "The effects of zinc oxide nanoparticles on Zn2+ homeostasis and neuron survival in human neuroblastoma SH-SY5Y cells." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/94118934544381399943.

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碩士<br>東吳大學<br>微生物學系<br>102<br>Zinc ion (Zn2+) plays vital roles in many biological functions, including DNA synthesis, enzyme activities, and plays as a secondary messenger in neuronal transduction. Our lab previously found that zinc oxide nanoparticles (ZnO-NPs) can get into brain via olfactory translocation. This study investigated if ZnO-NPs modulating Zn2+ homeostasis to manipulate cytoviability in human neuroblastoma SH-SY5Y cells. ZnO-NPs was labeled with fluorescein (F-ZnO) and the cytosolic entrance of F-ZnO was monitored by confocal microscopy. Lysotracker was used to localize lysosom

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Lin, Chin-Hsuan, та 林錦萱. "Study of Inhibitory Mechanisms of Isovitexin on β-Site APP Cleaving Enzyme Expression in Human Neuroblastoma SH-SY5Y Cells". Thesis, 2009. http://ndltd.ncl.edu.tw/handle/3he292.

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碩士<br>國立陽明大學<br>藥理學研究所<br>97<br>Abstract Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease. The processing of �namyloid precursor protein (APP) is initiated by beta-site APP cleaving enzyme 1 (BACE1) cleavage, which produce beta-cleaved C-terminal fragment (C99), and then further cleaved by γ-secretase leads to amyloid β-peptide (Aβ��)formation. Generation and deposition of Aβ is central to the aetiology of AD. Herein, BACE1 is a rate-limiting enzyme in the production of Aβ. Consequently, the enzyme activity, mRNA and protein levels of BACE1 are elevated in AD patie

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Hidayah, Kiswatul, та 哈文绮. "Equol Prevents Apoptosis in Aβ(25-35)-treated SH-SY5Y Human Neuroblastoma Cell Lines through Increasing Estrogen Receptor Expression". Thesis, 2014. http://ndltd.ncl.edu.tw/handle/x63c69.

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碩士<br>臺北醫學大學<br>保健營養學研究所<br>102<br>Background: β-amyloid (Aβ) formation in the brain is one of the characteristics of Alzheimer’s disease (AD). This peptide is the central role in the pathogenesis of AD with apoptosis comes out as the result. The effects of estrogen replacement therapy (ERT) on AD have been recognized, although associated with increased incidence of estrogen related cancer such as breast cancer. Equol is the metabolite form of daidzein, one of the major isoflavones in soybean product. By acting like estrogen, equol may have the same neuroprotective effect with estrogen that pr

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Juo, Liang-I., та 卓良益. "WW domain-containing oxidoreductase negatively regulates Glycogen Synthase Kinase 3β during neurite out growth in human neuroblastoma SH-SY5Y cells". Thesis, 2008. http://ndltd.ncl.edu.tw/handle/rd9m2a.

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碩士<br>國立中山大學<br>生物科學系研究所<br>96<br>WW domain-containing oxidoreductase WWOX, a putative tumor suppressor, has been suggested to be involved in the hyperphosphorylation of Alzheimer’s tau. Tau is a microtubule-associated protein which plays an important role in microtubule assembly and stability. GSK-3b regulates tau by phosphorylation as well as by regulating splice variance. Hyperphosphorylated tau has less affinity toward the microtubules and disrupting microtubule stability. By bioinformatics analysis, we found that WWOX has three GSK3β binding motifs, FXXXLI/VXRLE. The results of immunoprec

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WENG, CHING-YU, and 翁青瑜. "Protective Mechanism of Ubiquitin-specific Protease-1 Inhibitor ML323 in Preventing Against Paraquat-induced Human Neuroblastoma SH-SY5Y Cell Injury." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/9ky397.

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MURAKAMI, Masashi, and 真史村上. "ATRA inhibits ceramide kinase transcription through an ATRA-related transcription factor, COUP-TFI, in a human neuroblastoma cell line, SH-SY5Y." Thesis, 2010. http://hdl.handle.net/2237/14433.

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Wang, Sheng-Fan, and 王笙帆. "A Study of Molecular Mechanism of Mitochondrial Alterations and Cell Death in Response to Methamphetamine-induced Oxidative Stress in Human Neuroblastoma SH-SY5Y Cells." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/24848912016715865713.

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碩士<br>國立陽明大學<br>藥理學研究所<br>95<br>Methamphetamine (METH) is one of the most common abused drugs in Taiwan. It is an amphetamine analog that could result in neurotoxic damage. In a previous study, it was demonstrated in human neuroblastoma SH-SY5Y cells that METH induced a decreace in mitochondrial membrane potential and an increase in intracellular level of reactive oxygen species (ROS). In addition, mitochondrial mass was increased within 24 hours after exposure to METH, whereas mitochondrial membrane potential was extensively decreased. These results suggest that the function of the increased

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Lin, Yi-Chien, and 林怡倩. "Neuroprotective effects of ugonin K and furopyrazole derivatives on hydrogen peroxide-induced apoptosis in human neuroblastoma SH-SY5Y cells and C2 ceramide-induced apoptosis in primary cortical neurons." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/62785773575572533150.

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博士<br>中國醫藥大學<br>藥物化學研究所博士班<br>97<br>Oxidative stress is widely implicated in the neuron cell death that is associated with various neurodegenerative disorders such as Parkinson’s disease and Alzheimer’s disease. Ugonin K, a flavonoid isolated from the rhizomes of Helminthostachys zeylanica (L) Hook, possesses potent antioxidant property. In this study, we investigate the neuroprotective effects of ugonin K on hydrogen peroxide-induced apoptosis in SH-SY5Y cells. Incubation of SH-SY5Y cells with H2O2 for 24 h induced cell death measured with MTT assay. Hoechst 33258 staining confirmed that the

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