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Journal articles on the topic 'NEUROBLASTOMA HUMANO (SH-SY5Y)'

Author: Grafiati

Published: 18 April 2022

Last updated: 30 July 2025

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1

Castellanos, Jaime E., José I. Neissa, and Sigrid J. Camacho. "La infección con el virus del dengue induce apoptosis en células del neuroblastoma humano SH-SY5Y." Biomédica 36 (April 15, 2016): 156. http://dx.doi.org/10.7705/biomedica.v36i0.2984.

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<p><strong>Introducción.</strong> El dengue es una enfermedad humana producida por el virus del mismo nombre, que se transmite por la picadura de mosquitos del género <em>Aedes</em>. La infección tiene una amplia gama de presentaciones clínicas que van desde la ausencia de síntomas hasta los casos fatales y afecta principalmente a la población pediátrica. Según la nueva clasificación de la enfermedad, las manifestaciones neurológicas se consideran un criterio para el diagnóstico del dengue grave.<br /><strong>Objetivo.</strong> Evaluar los posibl

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VILLANUEVA SALAS, JOSE. "EVALUACIÓN DEL ESTRÉS OXIDATIVO EN CÉLULAS DE NEUROBLASTOMA HUMANO SH-SY5Y EXPUESTAS A EXTRACTOS PENTÁNICOS DE Lepedium Meyenii L." SCIENTIARVM 1, no. 1 (2015): 37–41. http://dx.doi.org/10.26696/sci.epg.0082.

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Lima, Washington Kleber Rodrigues, Cláudia Quintino da Rocha, Robertha Lemes, et al. "Efeito antiviral dos compostos isolados de flores de Arrabidaea brachypoda contra SARS-COV-2." Caderno Pedagógico 21, no. 8 (2024): e6462. http://dx.doi.org/10.54033/cadpedv21n8-056.

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A pandemia da COVID-19 teve um impacto global significativo devido ao elevado número de casos e mortes notificados. Apesar de vários medicamentos serem testados, poucos são eficazes e, devido à elevada taxa de mutação do SARS-CoV-2, os medicamentos disponíveis são limitados na sua utilização, daí a necessidade de obtenção de novas moléculas com atividade anti-SARS-CoV-2. Nesse sentido, utilizamos modelos in vitro para testar a atividade antiviral de dois compostos isolados: Quercitrina (Q) e Rutina (R) isolados das flores de Arrabidaea braquipoda. A análise de citotoxicidade demonstrou que as

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Nishtuk, Y. V., O. V. Stasyk, and O. G. Stasyk. "Spermidine activates authophagy but does not rescue human neuroblastoma SH-SY5Y cells from effects of arginine starvation." Studia Biologica 16, no. 3 (2022): 35–48. http://dx.doi.org/10.30970/sbi.1603.691.

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Background. Neuroblastoma is a malignant tumor of the sympathetic nervous system common in early childhood. Autophagy is manifested in neuroblastoma cells at basal levels, but is often upregulated in cells of the aggressive neuroblastoma forms. The aim of the study was to evaluate effects of polyamine spermidine and deficiency of arginine on cell viability and autophagy regulation in cells of human neuroblastoma. Materials and Methods. The human neuroblastoma SH-SY5Y cell line was an experimental model for the MTT assay of metabolic activity and cell viability upon exposure to different concen

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Karademir, Mustafa, and Merve Ergül. "Esomeprazole and pantoprazole enhance the antiproliferative effects of cisplatin on the human neuroblastoma SH-SY5Y cell line." International Journal of Research in Medical Sciences 7, no. 3 (2019): 734. http://dx.doi.org/10.18203/2320-6012.ijrms20190486.

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Background: Proton pump inhibitors (PPIs) largely used a drug to treat gastroesophageal disease such as gastric ulcers. Moreover, in recent years, several studies suggest that PPIs have an important anti-cancer effect in monotherapy and or combination with chemotherapy. The aim of this study was to investigate whether esomeprazole and pantoprazole exhibit anti-cancer effect alone or could enhance chemosensitivity on the human neuroblastoma cell line SH-SY5Y to cisplatin.Methods: The human neuroblastoma SH-SY5Y cells were cultured and treated with different concentrations of esomeprazole, panto

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Tian, P.-C., H.-L. Wang, G.-H. Chen, et al. "2,2′,4,4′-Tetrabromodiphenyl ether promotes human neuroblastoma SH-SY5Y cells migration via the GPER/PI3K/Akt signal pathway." Human & Experimental Toxicology 35, no. 2 (2015): 124–34. http://dx.doi.org/10.1177/0960327115578974.

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Neuroblastoma is the predominant tumor of early childhood. 2,2′,4,4′-Tetrabromodiphenyl ether (BDE-47) has the highest concentration among all polybrominated diphenyl ether (PBDE) congeners in human body, particularly for children. Considering that accumulating evidences showed developmental neurotoxicity of PBDE, there is an urgent need to investigate the effects of BDE-47 on the development of neuroblastoma. This study revealed that BDE-47 had limited effects on the cytotoxicity while significantly increased the in vitro migration and invasion of human neuroblastoma SH-SY5Y cells. This was f

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Serter Kocoglu, Sema, Mücahit Secme, Ceren Oy, Gözde Korkusuz, and Levent Elmas. "Monensin, an Antibiotic Isolated from Streptomyces Cinnamonensis, Regulates Human Neuroblastoma Cell Proliferation via the PI3K/AKT Signaling Pathway and Acts Synergistically with Rapamycin." Antibiotics 12, no. 3 (2023): 546. http://dx.doi.org/10.3390/antibiotics12030546.

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Neuroblastoma is the most common extracranial childhood tumor and accounts for approximately 15% of pediatric cancer-related deaths. Further studies are needed to identify potential therapeutic targets for neuroblastoma. Monensin is an ionophore antibiotic obtained from Streptomyces cinnamonensis with known antibacterial and antiparasitic effects. No study has reported the effects of monensin on SH-SY5Y neuroblastoma cells by targeting the PI3K/AKT signaling pathway. The aim of this study was to investigate the antiproliferative effects of monensin alone and in combination with rapamycin in hu

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Pak, Eun Joo, Gi Dong Son, and Byung Sun Yoo. "Cadmium Inhibits Neurite Outgrowth in Differentiating Human SH-SY5Y Neuroblastoma Cells." International Journal of Toxicology 33, no. 5 (2014): 412–18. http://dx.doi.org/10.1177/1091581814550338.

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Cadmium, a highly ubiquitous heavy metal, is well known to induce neurotoxicity. However, the underlying mechanism of cadmium-mediated neurotoxicity remains unclear. We have studied cadmium inhibition of neurite outgrowth using human SH-SY5Y neuroblastoma cells induced to differentiate by all- trans-retinoic acid (RA). Cadmium, at a concentration of 3 μmol/L, had no significant effect on the viability of differentiating SH-SY5Y cells. However, the neurite outgrowth of the differentiating SH-SY5Y cells 48 hours after cadmium treatment (1-3 μmol/L cadmium) was significantly inhibited in a dose-d

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Dai, Wei, Yan Lin, Sheng Gao, Peng Cheng Bi, Jin Hua He, and Shi Yun Li. "Effect of Competitive Adsorption of MicroRNA-1297 Between Metastasis-Associated Lung Adenocarcinoma Transcript 1 and E2F Transcription Factor 7 on the Proliferation of the Neuroblastoma Cell Line LA-N-5 Human Neuroblastoma Cell." Journal of Biomaterials and Tissue Engineering 12, no. 9 (2022): 1870–77. http://dx.doi.org/10.1166/jbt.2022.2617.

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Objective: To investigate: (1) the role of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in neuroblastoma cell proliferation and; (2) molecular mechanisms underlying the effect. Methods: The cell lines SH-SY5Y, SK-N-SH, and LA-N-5 (neuroblastomas) and the cell line HEK-293 (embryonic kidney) were cultured in vitro. We performed reverse transcription polymerase chain reaction to verify relative gene expressions; WST-8 assay to determine cell proliferation; colony formation assay to analyze cell clonogenic capacity; and western blotting to assess relative protein expressions. D

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Dervişoğlu, Gökhan. "Anticancer effects of sodium selenate in human neuroblastoma, breast cancer, and melanoma cells." International Journal of Secondary Metabolite 12, no. 1 (2025): 225–34. https://doi.org/10.21448/ijsm.1553575.

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Sodium selenate (Na2SeO4) is one of the oxidized inorganic forms of selenium. Effects on cytotoxicity, total antioxidant level, total oxidant level, oxidative stress, and genotoxicity status and its anticancer effect on SH-SY5Y human neuroblastoma, MCF-7 human breast cancer, and 451Lu human melanoma cells were investigated in this study. Sodium selenate exhibited a highly cytotoxic effect at all concentrations (0.078125 - 10 mg/mL) against SH-SY5Y, MCF-7, and 451Lu cancer cell lines. In addition, sodium selenate reduced the total antioxidant levels, increased the total oxidant levels (except f

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Russo, V. C., S. Metaxas, K. Kobayashi, M. Harris, and G. A. Werther. "Antiapoptotic Effects of Leptin in Human Neuroblastoma Cells." Endocrinology 145, no. 9 (2004): 4103–12. http://dx.doi.org/10.1210/en.2003-1767.

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Abstract Many factors regulate nervous system development, including complex cross-talk between local neuroendocrine systems. The adipocyte-secreted hormone leptin, mainly known for its key roles in nutrition and reproductive balance, may also be involved in neuroanatomical organization, myelination processes, and neuronal/glia maturation. SK-N-SH-SY5Y neuroblastoma cells were employed as an in vitro model of human neuronal cells to determine whether leptin exerts neuroprotective activities. We show that SH-SY5Y cells express leptin, the long and short isoforms of the leptin receptor (ObRl, Ob

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Onder, Seda, Lawrence M. Schopfer, Wei Jiang, Ozden Tacal, and Oksana Lockridge. "Butyrylcholinesterase in SH-SY5Y human neuroblastoma cells." NeuroToxicology 90 (May 2022): 1–9. http://dx.doi.org/10.1016/j.neuro.2022.02.006.

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ZHAO, SHIJIA, ALEX STAMM, JEONG SOON LEE, ALEXEI GRUVERMAN, JUNG YUL LIM, and LINXIA GU. "ELASTICITY OF DIFFERENTIATED AND UNDIFFERENTIATED HUMAN NEUROBLASTOMA CELLS CHARACTERIZED BY ATOMIC FORCE MICROSCOPY." Journal of Mechanics in Medicine and Biology 15, no. 05 (2015): 1550069. http://dx.doi.org/10.1142/s0219519415500694.

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Human neuroblastoma (SH-SY5Y) cells, with its ability to differentiate into neurons, have been widely used as the in vitro cell culture model for neuroscience research, especially in studying the pathogenesis of Parkinson's disease (PD) and developing therapeutic strategies. Cellular elasticity could potentially serve as a biomarker to quantitatively distinguish undifferentiated and differentiated SH-SY5Y cells. The goal of this work is to characterize the retinoic acid (RA) induced alternations of elastic properties of SH-SY5Y cells using atomic force microscopy (AFM). The elasticity was meas

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Chetsawang, Jirapa, Piyarat Govitrapong, and Banthit Chetsawang. "Hydrogen Peroxide Toxicity Induces Ras Signaling in Human Neuroblastoma SH-SY5Y Cultured Cells." Journal of Biomedicine and Biotechnology 2010 (2010): 1–4. http://dx.doi.org/10.1155/2010/803815.

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It has been reported that overproduction of reactive oxygen species occurs after brain injury and mediates neuronal cells degeneration. In the present study, we examined the role of Ras signaling on hydrogen peroxide-induced neuronal cells degeneration in dopaminergic neuroblastoma SH-SY5Y cells. Hydrogen peroxide significantly reduced cell viability in SH-SY5Y cultured cells. An inhibitor of the enzyme that catalyzes the farnesylation of Ras proteins, FTI-277, and a competitive inhibitor of GTP-binding proteins, GDP-beta-S significantly decreased hydrogen peroxide-induced reduction in cell vi

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Aslan, Ali, and Mücahit Seçme. "Effects of Pelargonium Sidoides Extract on Apoptosis and Oxidative Stress in Human Neuroblastoma Cells." Medicina 60, no. 12 (2024): 2110. https://doi.org/10.3390/medicina60122110.

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Background and Objectives: Neuroblastoma is the most common extracranial solid tumor in children, often presenting challenges in treatment due to its clinical and genetic heterogeneity. This study investigated the anticancer potential of Pelargonium sidoides root extract on the human neuroblastoma cell line (SH-SY5Y). Using XTT assays, ELISA-based oxidative stress markers, and RT-PCR analysis of apoptotic genes, the study explored the extract’s effects on cell proliferation, oxidative stress, and apoptosis. Materials and Methods: For the cell culture, SH-SY5Y human neuroblastoma cells were tha

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Acioglu, Cigdem, Mete Bora Tuzuner, Muge Serhatli, et al. "A Proteomic Analysis of Mitochondrial Complex III Inhibition in SH-SY5Y Human Neuroblastoma Cell Line." Current Proteomics 16, no. 2 (2019): 136–47. http://dx.doi.org/10.2174/1570164615666180713110139.

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Background and Objective: Antimycin A (AntA) is a potent Electron Transport System (ETS) inhibitor exerting its effect through inhibiting the transfer of the electrons by binding to the quinone reduction site of the cytochrome bc1 complex (Complex III), which is known to be impaired in Huntington’s Disease (HD). The current studies were undertaken to investigate the effect of complex III inhibition in the SH-SY5Y cell line to delineate the molecular and cellular processes, which may play a role in the pathogenesis of HD. Methods: We treated SH-SY5Y neuroblastoma cells with AntA in order to est

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Vasarri, Marzia, Giovanni Andrea Vitale, Giovanna Cristina Varese, et al. "Dihydroauroglaucin Isolated from the Mediterranean Sponge Grantia compressa Endophyte Marine Fungus Eurotium chevalieri Inhibits Migration of Human Neuroblastoma Cells." Pharmaceutics 14, no. 3 (2022): 616. http://dx.doi.org/10.3390/pharmaceutics14030616.

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Cancer cell migration is a hallmark of the aggressiveness and progression of malignancies such as high-risk neuroblastoma. Given the lack of effective therapeutic solutions to counteract cancer progression, basic research aims to identify novel bioactive molecules with inhibitory potential on cancer cell migration. In this context, this work investigated the role of members of the salicylaldehyde secondary metabolite set from the sponge endophyte fungus Eurotium chevalieri MUT 2316 as potential inhibitors of human neuroblastoma SH-SY5Y cell migration. Since tetrahydroauroglaucin (TAG) and dihy

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Marzia, Vasarri, Andrea Vitale Giovanni, Cristina Varese Giovanna, et al. "Dihydroauroglaucin Isolated from the Mediterranean Sponge Grantia compressa Endophyte Marine Fungus Eurotium chevalieri Inhibits Migration of Human Neuroblastoma Cells." Pharmaceutics 14, no. 3 (2022): 616. https://doi.org/10.3390/pharmaceutics14030616.

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Cancer cell migration is a hallmark of the aggressiveness and progression of malignancies such as high-risk neuroblastoma. Given the lack of effective therapeutic solutions to counteract cancer progression, basic research aims to identify novel bioactive molecules with inhibitory potential on cancer cell migration. In this context, this work investigated the role of members of the salicylaldehyde secondary metabolite set from the sponge endophyte fungus Eurotium chevalieri MUT 2316 as potential inhibitors of human neuroblastoma SH-SY5Y cell migration. Since tetrahydroauroglaucin (TAG) and dihy

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Motta, Luiz Augusto Casulari Roxo da, Paola Galli, Flavio Piva, and Roberto Maggi. "Effects of epidermal growth factor on the [3H]-thymidine uptake in the SK-N-SH and SH-SY5Y human neuroblastoma cell lines." Arquivos de Neuro-Psiquiatria 55, no. 3A (1997): 444–51. http://dx.doi.org/10.1590/s0004-282x1997000300016.

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The studies on the factors that regulate the biology of the neuroblastoma cell lines may offer important information on the development of tissues and organs that derive from the neural crest. In the present paper we study the action of epidermal growth factor (EGF) on two human neuroblastoma cell lines: SK-N-SH which is composed at least of two cellular phenotypes (neuroblastic and melanocytic/glial cells), and its pure neuroblastic subclone SH-SY5Y. The results show that EGF (10 ng/ml) significantly stimulates the incorporation of [3H]-thymidine in the SK-N-SH cells only in the presence of f

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Poulose, Shibu M., Edward D. Harris, and Bhimanagouda S. Patil. "Citrus Limonoids Induce Apoptosis in Human SH-SY5Y Neuroblastoma Cancer Cells." HortScience 40, no. 4 (2005): 1135E—1136. http://dx.doi.org/10.21273/hortsci.40.4.1135e.

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Limonoids are triterpinoids unique to citrus and neem trees with potential cancer-preventing properties in animals and human cell lines. Antioxidant activity and apoptotic induction are thought to be the principal effects of citrus limonoids in the antiproliferative properties, but this postulate lacks firm experimental evidence. In this study four highly purified 17 β-D glucopyranosides of citrus, limonin glucoside (LG), obacunone glucoside (OG), nomilinic acid glucoside (NAG), and deacetylnomilinic acid glucoside (DNAG), were tested for their effects against human SH-SY5Y neuroblastoma cells

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An, Xinfang, Zixing Fu, Chendi Mai, et al. "Increasing the TRPM2 Channel Expression in Human Neuroblastoma SH-SY5Y Cells Augments the Susceptibility to ROS-Induced Cell Death." Cells 8, no. 1 (2019): 28. http://dx.doi.org/10.3390/cells8010028.

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Human neuroblastoma SH-SY5Y cells are a widely-used human neuronal cell model in the study of neurodegeneration. A recent study shows that, 1-methyl-4-phenylpyridine ion (MPP), which selectively causes dopaminergic neuronal death leading to Parkinson’s disease-like symptoms, can reduce SH-SY5Y cell viability by inducing H2O2 generation and subsequent TRPM2 channel activation. MPP-induced cell death is enhanced by increasing the TRPM2 expression. By contrast, increasing the TRPM2 expression has also been reported to support SH-SY5Y cell survival after exposure to H2O2, leading to the suggestion

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Hasbullah, N. I., Mat Zain Mazatulikhma, and N. Kamarulzaman. "Nanotoxicity of Magnesium Oxide on Human Neuroblastoma SH-SY5Y Cell Lines." Advanced Materials Research 667 (March 2013): 160–64. http://dx.doi.org/10.4028/www.scientific.net/amr.667.160.

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The use of magnesium oxide (MgO) nanoparticles in industrial applications has been raised over the last decade. However, there is limited toxicology information available regarding the effects of MgO nanoparticles. In this study, cytotoxicity and neurotoxicity of this nanoparticle on SH-SY5Y cell lines was investigated. In order to assess the cytotoxicity effect, SH-SY5Y cells were exposed to three different types of MgO nanoparticles (MgO 5, MgO 10 and MgO 24) for 24, 48 and 72 h. The concentration of nanoparticles ranges from 1nM to 1mM. Cell viability was determined by MTS assay. Neurotoxic

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Epimakhova, E., E. Ermakov, D. Kazantseva, et al. "DNA-hydrolyzing catalytic IgGs from schizophrenia patients do not affect cell viability of the SH-SY5Y human neuroblastoma cell line." European Psychiatry 65, S1 (2022): S775. http://dx.doi.org/10.1192/j.eurpsy.2022.2002.

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Introduction DNA-hydrolyzing catalytic IgGs have caspase-dependent cytotoxic effects in autoimmune diseases. Recently, DNA-hydrolyzing IgGs have been discovered in schizophrenia. However, their cytotoxic properties have not been studied. Objectives To assess the effect of serum IgGs with DNA-hydrolyzing activity of schizophrenia patients on the cell viability of the SH-SY5Y human neuroblastoma cell line. Methods Serum of 8 patients with paranoid schizophrenia in the acute phase and 7 mentally and somatically healthy persons were used. IgG was purified from serum by affinity chromatography on P

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Ng, Yee-Wen, and Yee-How Say. "Palmitic acid induces neurotoxicity and gliatoxicity in SH-SY5Y human neuroblastoma and T98G human glioblastoma cells." PeerJ 6 (April 26, 2018): e4696. http://dx.doi.org/10.7717/peerj.4696.

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Background Obesity-related central nervous system (CNS) pathologies like neuroinflammation and reactive gliosis are associated with high-fat diet (HFD) related elevation of saturated fatty acids like palmitic acid (PA) in neurons and astrocytes of the brain. Methods Human neuroblastoma cells SH-SY5Y (as a neuronal model) and human glioblastoma cells T98G (as an astrocytic model), were treated with 100–500 µM PA, oleic acid (OA) or lauric acid (LA) for 24 h or 48 h, and their cell viability was assessed by 3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The effects of s

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Kitaeva, Kristina V., Daria S. Chulpanova, Margarita N. Zhuravleva, et al. "Characteristics and Resistance to Cisplatin of Human Neuroblastoma Cells Co-Cultivated with Immune and Stromal Cells." Bioengineering 9, no. 11 (2022): 655. http://dx.doi.org/10.3390/bioengineering9110655.

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We investigated the features of the morphology and cytokine profiles of neuroblastoma SH-SY5Y cells, bone marrow-derived mesenchymal stromal/stem cells (BM-MSCs), and peripheral blood mononuclear cells (PBMCs) in double (BM-MSCs + SH-SY5Y cells) and triple (BM-MSCs + SH-SY5Y cells + PBMCs) co-cultures incubated on plastic and Matrigel. Cells in the co-cultures communicated by vesicular transport and by exchanging membrane and cytoplasmic components. The cytokine profile of double and triple co-cultures incubated on Matrigel and plastic had differences and showed the highest concentration of a

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Kalinovskii, Aleksandr P., Dmitry I. Osmakov, Sergey G. Koshelev, et al. "Retinoic Acid-Differentiated Neuroblastoma SH-SY5Y Is an Accessible In Vitro Model to Study Native Human Acid-Sensing Ion Channels 1a (ASIC1a)." Biology 11, no. 2 (2022): 167. http://dx.doi.org/10.3390/biology11020167.

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Human neuroblastoma SH-SY5Y is a prominent neurobiological tool used for studying neuropathophysiological processes. We investigated acid-sensing (ASIC) and transient receptor potential vanilloid-1 (TRPV1) and ankyrin-1 (TRPA1) ion channels present in untreated and differentiated neuroblastoma SH-SY5Y to propose a new means for their study in neuronal-like cells. Using a quantitative real-time PCR and a whole-cell patch-clamp technique, ion channel expression profiles, functionality, and the pharmacological actions of their ligands were characterized. A low-level expression of ASIC1a and ASIC2

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Cianfarani, Stefano, Daniela Germani, Paola Rossi, Anna Spagnoli, and Delio Mercanti. "Do insulin-like growth factor binding proteins (IGFBPs) modulate the IGF-I growth promoting and differentiating effects in human neuroblastoma cells?" European Journal of Endocrinology 135, no. 6 (1996): 716–23. http://dx.doi.org/10.1530/eje.0.1350716.

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Cianfarani S, Germani D, Rossi P, Spagnoli A, Mercanti D. Do insulin-like growth factor binding proteins (IGFBPs) modulate the IGF-I growth promoting and differentiating effects in human neuroblastoma cells? Eur J Endocrinol 1996;135:716–23. ISSN 0804–4643 The insulin-like growth factors (IGFs) are known to stimulate both the proliferation and differentiation of neuroblastoma cells, but the role of the IGF binding proteins (IGFBPs) has not yet been established. In this study, human neuroblastoma SH-SY5Y cells have been treated with IGF-I and its potent analogue des (1–3) IGF-I alone or followi

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Berrocal, Maria, Juan J. Cordoba-Granados, Sónia A. C. Carabineiro, Carlos Gutierrez-Merino, Manuel Aureliano, and Ana M. Mata. "Gold Compounds Inhibit the Ca2+-ATPase Activity of Brain PMCA and Human Neuroblastoma SH-SY5Y Cells and Decrease Cell Viability." Metals 11, no. 12 (2021): 1934. http://dx.doi.org/10.3390/met11121934.

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Plasma membrane calcium ATPases (PMCA) are key proteins in the maintenance of calcium (Ca2+) homeostasis. Dysregulation of PMCA function is associated with several human pathologies, including neurodegenerative diseases, and, therefore, these proteins are potential drug targets to counteract those diseases. Gold compounds, namely of Au(I), are well-known for their therapeutic use in rheumatoid arthritis and other diseases for centuries. Herein, we report the ability of dichloro(2-pyridinecarboxylate)gold(III) (1), chlorotrimethylphosphinegold(I) (2), 1,3-bis(2,6-diisopropylphenyl)imidazol-2-yl

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Kitidee, Kuntida, Sumet Amonyingcharoen, Sarinthip Preedagasamzin та ін. "Combining CD3/GD2 bispecific T cell engager with human Vγ9Vδ2 T cells facilitates neuroblastoma cell targeting and killing in vitro". PLOS One 20, № 6 (2025): e0325389. https://doi.org/10.1371/journal.pone.0325389.

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Cancer immunotherapy, particularly T cell–based therapies, is considered to have strong potential for treating various types of cancer. A promising approach that has emerged is the use of γδ T cell-based strategies for cancer treatment. Neuroblastoma (NB), a solid tumor frequently found in childhood, is one of the more intriguing targets for immunotherapy. In this study, we report an alternative immunotherapy method for treating neuroblastoma by combining bispecific antibody with human Vγ9Vδ2 T cells. Initially, we screened for human scFv against CD3 epsilon using phage panning technology. Hum

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Stolze, Ineke, Utta Berchner-Pfannschmidt, Patricia Freitag, et al. "Hypoxia-inducible erythropoietin gene expression in human neuroblastoma cells." Blood 100, no. 7 (2002): 2623–28. http://dx.doi.org/10.1182/blood-2001-12-0169.

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Two human neuroblastoma (NB) cell lines, SH-SY5Y and Kelly, were found to express the gene for erythropoietin (EPO) in an oxygen (O2)-dependent manner. However, NB cells had maximal production of EPO with lower partial pressure of O2 values than the well-characterized hepatoma cell line HepG2. This maximal EPO expression was preceded by accumulation of the O2-sensitive α subunit of the heterodimeric transcription-factor complex hypoxia-inducible factor 1 (HIF-1). Western blot analysis revealed that the amount of the β subunit of HIF-1, identical to aryl hydrocarbon receptor nuclear translocato

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Sekhri, Palak, Debbie K. Ledezma, Anshi Shukla, Elizabeth E. Sweeney, and Rohan Fernandes. "The Thermal Dose of Photothermal Therapy Generates Differential Immunogenicity in Human Neuroblastoma Cells." Cancers 14, no. 6 (2022): 1447. http://dx.doi.org/10.3390/cancers14061447.

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Photothermal therapy (PTT) is an effective method for tumor eradication and has been successfully combined with immunotherapy. However, besides its cytotoxic effects, little is known about the effect of the PTT thermal dose on the immunogenicity of treated tumor cells. Therefore, we administered a range of thermal doses using Prussian blue nanoparticle-based photothermal therapy (PBNP-PTT) and assessed their effects on tumor cell death and concomitant immunogenicity correlates in two human neuroblastoma cell lines: SH-SY5Y (MYCN-non-amplified) and LAN-1 (MYCN-amplified). PBNP-PTT generated the

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Zhang, Yuan, Tun Sun, Meng Li, et al. "Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy." Antioxidants 11, no. 5 (2022): 908. http://dx.doi.org/10.3390/antiox11050908.

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Ivermectin (IVM) could cause potential neurotoxicity; however, the precise molecular mechanisms remain unclear. This study explores the cytotoxicity of IVM in human neuroblastoma (SH-SY5Y) cells and the underlying molecular mechanisms. The results show that IVM treatment (2.5–15 μM) for 24 h could induce dose-dependent cell death in SH-SY5Y cells. Compared to the control, IVM treatment significantly promoted the production of ROS, mitochondrial dysfunction, and cell apoptosis. IVM treatment also promoted mitophagy and autophagy, which were charactered by the decreased expression of phosphoryla

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BLANCHARD, STEPHEN, JOHN H. WALKER, and PETER F. T. VAUGHAN. "Expression of annexins in the human neuroblastoma SH-SY5Y." Biochemical Society Transactions 21, no. 3 (1993): 315S. http://dx.doi.org/10.1042/bst021315s.

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Orciani, M., O. Trubiani, G. Cavaletti, et al. "Expression of CD38 in Human Neuroblastoma Sh-SY5Y Cells." International Journal of Immunopathology and Pharmacology 21, no. 1 (2008): 97–105. http://dx.doi.org/10.1177/039463200802100111.

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HIRST, ROBERT A., and DAVID G. LAMBERT. "Do SH-SY5Y Human Neuroblastoma Cells Express Cannabinoid Receptors ?" Biochemical Society Transactions 23, no. 3 (1995): 418S. http://dx.doi.org/10.1042/bst023418s.

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Parsley, Stephanie, Lucien Gazi, Ionel Bobirnac, Erika Loetscher та Philippe Schoeffter. "Functional α2C-adrenoceptors in human neuroblastoma SH-SY5Y cells". European Journal of Pharmacology 372, № 1 (1999): 109–15. http://dx.doi.org/10.1016/s0014-2999(99)00190-9.

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Gould, J., H. L. Reeve, P. F. T. Vaughan, and C. Peers. "Nicotinic acetylcholine receptors in human neuroblastoma (SH-SY5Y) cells." Neuroscience Letters 145, no. 2 (1992): 201–4. http://dx.doi.org/10.1016/0304-3940(92)90022-y.

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Mat Zain, Mazatulikhma Mat Zain, Nursyamila Shamsuddin, and Mohd Shihabuddin Ahmad Noorden. "The The Effects of Centella asiatica Extract (CAE) on Methamphetamine-Induced Neurotoxicity via Human Neuroblastoma Cell Line." ASM Science Journal 16 (November 5, 2021): 1–9. http://dx.doi.org/10.32802/asmscj.2021.907.

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Methamphetamine (METH) was reported to caused neurotoxicity and cell death, in vitro. Centella asiatica or ‘pegaga’ is a native tropical herb with antioxidant and neuroprotective activities. Although the effects of Centella asiatica against oxidative stress and neuronal cell death have been reported in previous studies, however, the potential effects of Centella asiatica against psychostimulant methamphetamine (METH) are limited. Therefore, this study was aimed to evaluate the effects of Centella asiatica extract (CAE) against METH on all-trans retinoic acid, RA-differentiated human neuroblast

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Turner, N. A., M. G. Rumsby, J. H. Walker, F. A. McMorris, S. G. Ball та P. F. Vaughan. "A role for protein kinase C subtypes α and ε in phorbol-ester-enhanced K+- and carbachol-evoked noradrenaline release from the human neuroblastoma SH-SY5Y". Biochemical Journal 297, № 2 (1994): 407–13. http://dx.doi.org/10.1042/bj2970407.

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Protein kinase C (PKC) consists of a family of closely related subtypes which differ in their localization and activation properties. Our previous studies have suggested a role for PKC in the regulation of noradrenaline (NA) release from the human neuroblastoma SH-SY5Y. Here we have used two approaches to characterize the PKC subtypes present in SH-SY5Y cells. Firstly, the PCR was used to show that SH-SY5Y cells contain mRNA encoding PKC subtypes alpha, beta, gamma, delta, epsilon and zeta. Secondly, immunoblotting showed that SH-SY5Y cells express PKC subtypes alpha, epsilon and zeta at the p

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Roytrakul, Sittiruk, Janthima Jaresitthikunchai, Narumon Phaonakrop, et al. "Secretomic changes of amyloid beta peptides on Alzheimer’s disease related proteins in differentiated human SH-SY5Y neuroblastoma cells." PeerJ 12 (July 17, 2024): e17732. http://dx.doi.org/10.7717/peerj.17732.

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Alzheimer’s disease (AD) is a neurodegenerative disease that causes physical damage to neuronal connections, leading to brain atrophy. This disruption of synaptic connections results in mild to severe cognitive impairments. Unfortunately, no effective treatment is currently known to prevent or reverse the symptoms of AD. The aim of this study was to investigate the effects of three synthetic peptides, i.e., KLVFF, RGKLVFFGR and RIIGL, on an AD in vitro model represented by differentiated SH-SY5Y neuroblastoma cells exposed to retinoic acid (RA) and brain-derived neurotrophic factor (BDNF). The

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Gurunathan, Jeyaraj, Kang, and Kim. "Mitochondrial Peptide Humanin Protects Silver Nanoparticles-Induced Neurotoxicity in Human Neuroblastoma Cancer Cells (SH-SY5Y)." International Journal of Molecular Sciences 20, no. 18 (2019): 4439. http://dx.doi.org/10.3390/ijms20184439.

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The extensive usage of silver nanoparticles (AgNPs) as medical products such as antimicrobial and anticancer agents has raised concerns about their harmful effects on human beings. AgNPs can potentially induce oxidative stress and apoptosis in cells. However, humanin (HN) is a small secreted peptide that has cytoprotective and neuroprotective cellular effects. The aim of this study was to assess the harmful effects of AgNPs on human neuroblastoma SH-SY5Y cells and also to investigate the protective effect of HN from AgNPs-induced cell death, mitochondrial dysfunctions, DNA damage, and apoptosi

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Mattsson, M. E., G. Enberg, A. I. Ruusala, K. Hall, and S. Påhlman. "Mitogenic response of human SH-SY5Y neuroblastoma cells to insulin-like growth factor I and II is dependent on the stage of differentiation." Journal of Cell Biology 102, no. 5 (1986): 1949–54. http://dx.doi.org/10.1083/jcb.102.5.1949.

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Human insulin-like growth factor I and II (IGF-I and IGF-II) in concentrations of 1-30 ng/ml, were shown to stimulate ornithine decarboxylase activity and [3H]thymidine incorporation in human SH-SY5Y neuroblastoma cells. Proliferation of these cells was also stimulated by IGF-I and II when added to RPMI 1640 medium, fortified with selenium, hydrocortisone, transferrin, and beta-estradiol. Labeled IGF-I and II bound to SH-SY5Y cells. The cross-reaction pattern of IGF-I, IGF-II, and insulin in competing with the binding of labeled IGF-I and IGF-II, respectively, indicated that SH-SY5Y cells expr

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Hina, S. "Translational inhibitors as potential therapeutic tool of human neuroblastoma through mitochondrial gene expression." European Psychiatry 41, S1 (2017): S464. http://dx.doi.org/10.1016/j.eurpsy.2017.01.517.

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Neuroblastoma is a solid neuroendocrine tumour and most common type of cancer of infancy. It is a complex heterogeneous disease and many factors such as molecular, cellular and genetic features are involved in its development. Mitochondria play a pivotal role in neuronal cell survival or death. Neurons are highly reliant on aerobic oxidative phosphorylation (OXPHOS) for their energy needs. Defective activities of mitochondrial complexes I, II, III and IV have been identified in many neurological and neurodegenerative diseases. Human mitochondria with its own genetic material meet the needs req

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Juntunen, Miia, Sanna Hagman, Anaick Moisan, Susanna Narkilahti, and Susanna Miettinen. "In Vitro Oxygen-Glucose Deprivation-Induced Stroke Models with Human Neuroblastoma Cell- and Induced Pluripotent Stem Cell-Derived Neurons." Stem Cells International 2020 (October 29, 2020): 1–13. http://dx.doi.org/10.1155/2020/8841026.

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Stroke is a devastating neurological disorder and one of the leading causes of mortality and disability. To understand the cellular and molecular mechanisms of stroke and to develop novel therapeutic approaches, two different in vitro human cell-based stroke models were established using oxygen-glucose deprivation (OGD) conditions. In addition, the effect of adipose stem cells (ASCs) on OGD-induced injury was studied. In the present study, SH-SY5Y human neuroblastoma cells and human induced pluripotent stem cells (hiPSCs) were differentiated into neurons, cultured under OGD conditions (1% O2)

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Adornetto, Annagrazia, Maria Luisa Laganà, Andrea Satriano, et al. "The Antidepressant Drug Amitriptyline Affects Human SH-SY5Y Neuroblastoma Cell Proliferation and Modulates Autophagy." International Journal of Molecular Sciences 25, no. 19 (2024): 10415. http://dx.doi.org/10.3390/ijms251910415.

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Amitriptyline is a tricyclic antidepressant commonly used for depressive disorders and is prescribed off-label for several neurological conditions like neuropathic pain, migraines and anxiety. Besides their action on the reuptake of monoaminergic neurotransmitters, tricyclic antidepressants interact with several additional targets that may contribute to either therapeutic or adverse effects. Here, we investigated the effects of amitriptyline on proliferation and autophagy (i.e., an evolutionarily conserved catabolic pathway responsible for the degradation and recycling of cytoplasmic material)

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Offermanns, S., E. Bombien, and G. Schultz. "Stimulation of tyrosine phosphorylation and mitogen-activated-protein (MAP) kinase activity in human SH-SY5Y neuroblastoma cells by carbachol." Biochemical Journal 294, no. 2 (1993): 545–50. http://dx.doi.org/10.1042/bj2940545.

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Activation of the G-protein-coupled muscarinic (M3) receptor in human neuroblastoma SH-SY5Y cells is known to lead to phosphoinositol hydrolysis and noradrenaline release. In this study, the effect of carbachol on tyrosine phosphorylation and mitogen-activated protein (MAP) kinase activity in SH-SY5Y cells was examined. Carbachol concentration-dependently induced tyrosine phosphorylation of several proteins, including one of 42 kDa. This tyrosine-phosphorylated 42 kDa protein co-eluted from a Mono Q anion-exchange column with MAP kinase activity and with immunologically detected MAP kinase. St

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Hernández, Raúl Bonne, Nadja C. de Souza-Pinto, Jos Kleinjans, et al. "Manganese-Induced Neurotoxicity through Impairment of Cross-Talk Pathways in Human Neuroblastoma Cell Line SH-SY5Y Differentiated with Retinoic Acid." Toxics 9, no. 12 (2021): 348. http://dx.doi.org/10.3390/toxics9120348.

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Manganese (Mn) is an important element; yet acute and/or chronic exposure to this metal has been linked to neurotoxicity and neurodegenerative illnesses such as Parkinson’s disease and others via an unknown mechanism. To better understand it, we exposed a human neuroblastoma cell model (SH-SY5Y) to two Mn chemical species, MnCl2 and Citrate of Mn(II) (0–2000 µM), followed by a cell viability assay, transcriptomics, and bioinformatics. Even though these cells have been chemically and genetically modified, which may limit the significance of our findings, we discovered that by using RA-different

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Khritankova, I. V., M. S. Kukharskiy, O. A. Lytkina, S. O. Bachurin, and B. Y. Shorning. "Dimebon activates autophagosome components in human neuroblastoma SH-SY5Y cells." Doklady Biochemistry and Biophysics 446, no. 1 (2012): 251–53. http://dx.doi.org/10.1134/s1607672912050079.

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Lu, Rong, Ling Song, and Richard S. Jope. "Lithium attenuates p53 levels in human neuroblastoma SH-SY5Y cells." NeuroReport 10, no. 5 (1999): 1123–25. http://dx.doi.org/10.1097/00001756-199904060-00040.

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Repetto, G., J. C. Rios, A. Jos, M. Salguero, and A. Camean. "Metoclopramide induced the differentiation of SH-SY5Y human neuroblastoma cells." Toxicology Letters 205 (August 2011): S174. http://dx.doi.org/10.1016/j.toxlet.2011.05.606.

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