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1

Bouferraa, Youssef, Maroun Bou Zerdan, Ramzi Hamouche, Eid Azar, Claude Afif, and Rosette Jabbour. "Neurobrucellosis." Neurologist 26, no. 6 (2021): 248–52. http://dx.doi.org/10.1097/nrl.0000000000000348.

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2

Zheng, Na, Wei Wang, Jia-Tang Zhang, et al. "Neurobrucellosis." International Journal of Neuroscience 128, no. 1 (2017): 55–62. http://dx.doi.org/10.1080/00207454.2017.1363747.

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3

Kizilkilic, Osman, and Cem Calli. "Neurobrucellosis." Neuroimaging Clinics of North America 21, no. 4 (2011): 927–37. http://dx.doi.org/10.1016/j.nic.2011.07.008.

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4

Tanyel, Esra. "Neurobrucellosis." Ortadoğu Tıp Dergisi 9, no. 1 (2017): 39–41. http://dx.doi.org/10.21601/ortadogutipdergisi.285452.

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5

Shakir, R. A. "Neurobrucellosis." Postgraduate Medical Journal 62, no. 734 (1986): 1077–79. http://dx.doi.org/10.1136/pgmj.62.734.1077.

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6

Soares, Cristiane N., Marcus Tulius T. da Silva, and Marco Antonio Lima. "Neurobrucellosis." Current Opinion in Infectious Diseases 36, no. 3 (2023): 192–97. http://dx.doi.org/10.1097/qco.0000000000000920.

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7

Ayoobi Yazdi, Niloofar, Najme-sadat Moosavi, Samira Alesaeidi, Faeze Salahshour, and Omid Ghaemi. "Diffuse Neurobrucellosis of Cerebellum, Brainstem, Spinal Cord, and Cauda Equina: A case report and Literature review." Journal of Radiology Case Reports 16, no. 5 (2022): 1–9. http://dx.doi.org/10.3941/jrcr.v16i5.3960.

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Neurobrucellosis is an uncommon serious complication of brucellosis. Diagnosis of neurobrucellosis could be difficult due to non-specific clinical and radiological findings. So, in endemic regions, neurobrucellosis should be included in the differential diagnosis list of patients with recent neurological disorders. We report an unusual case of neurobrucellosis with neurologic deficits in the central and peripheral nervous system and MRI lesions in the brainstem, spinal cord, and nerve roots Also, related articles are reviewed in the discussion section.
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8

Alothman, Adel, Saud Al Dubayan, Ali Al Khathaami, Suleiman Kojan, and Salih Bin Salih. "Neurobrucellosis: Challenges for Therapy." Infectious Diseases: Research and Treatment 5 (January 2012): IDRT.S8649. http://dx.doi.org/10.4137/idrt.s8649.

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Background Brucellosis is a common zoonotic infection throughout the world, and is endemic in Saudi Arabia. Neurobrucellosis is a rare, severe form of systemic brucella infection. Treatment of neurobrucellosis continues to be variable, depending on the location of diagnosis. Methods A retrospective patient chart review was undertaken from 1995 to 2010 at King Abdulaziz Medical City, Riyadh, to identify cases of neurobrucellosis following a proposed case definition. Follow-up visits were evaluated to determine response to treatment. Results A total of 22 cases of neurobrucellosis were identifie
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9

Papadopoulos, Vassilis E., Kostas Patas, Argyro Tountopoulou, et al. "Seronegative neurobrucellosis—do we need new neurobrucellosis criteria?" International Journal of Infectious Diseases 111 (October 2021): 124–26. http://dx.doi.org/10.1016/j.ijid.2021.08.038.

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10

International, Journal of Medical Science and Innovative Research (IJMSIR). "Neurobrucellosis, an Unusual Culprit in Sensoneural hearing loss and Acute Psychosis – A Riveting Clinical Case Exploration." International Journal of Medical Science and Innovative Research (IJMSIR) 9, no. 1 (2024): 106–10. https://doi.org/10.5281/zenodo.15363780.

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<strong>Abstract</strong> Neurobrucellosis, an exceptional neurological complication stemming from Brucella infection, is renowned for its diverse clinical expressions. Delving into the extraordinary, this study unveils a captivating clinical case illuminating the atypical manifestation of Neurobrucellosis as acute psychosis. The patient, devoid of any precedent psychiatric history, displayed a sudden onset of psychotic symptoms, featuring agitated behavior, disjointed speech, restlessness, intermittent crying, and a 4-day bout of sleep disruption, necessitating a thorough diagnostic inquiry.
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11

KIRIK, Serkan, Yasemin KIRIK, and Olcay GÜNGÖR. "Neurobrucellosis in Childhood." Turkiye Klinikleri Journal of Pediatrics 27, no. 2 (2018): 70–74. http://dx.doi.org/10.5336/pediatr.2017-58607.

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12

Lambrecht, Richard M. "Diagnosis of Neurobrucellosis." Annals of Saudi Medicine 8, no. 6 (1988): 508. http://dx.doi.org/10.5144/0256-4947.1988.508.

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13

Kesav, P., V. Y. Vishnu, and D. Khurana. "Fatal disseminated neurobrucellosis." QJM 107, no. 4 (2013): 321–22. http://dx.doi.org/10.1093/qjmed/hct135.

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14

Molins, A., J. Montalban, and A. Codina. "Parkinsonism in neurobrucellosis." Journal of Neurology, Neurosurgery & Psychiatry 50, no. 12 (1987): 1707–8. http://dx.doi.org/10.1136/jnnp.50.12.1707-a.

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15

Roldán-Montaud, Alberto, Félix Javier Jiménez-Jiménez, Fernando Zancada, José Antonio Molina-Arjona, Angel Fernández-Ballesteros, and Agustin Gutiérrez-Vivas. "Neurobrucellosis Mimicking Migraine." European Neurology 31, no. 1 (1991): 30–32. http://dx.doi.org/10.1159/000116631.

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16

Hendaus, Mohamed Ata, Rasha Muneer Qaqish, and Ahmed Hassan Alhammadi. "Neurobrucellosis in children." Asian Pacific Journal of Tropical Biomedicine 5, no. 2 (2015): 158–61. http://dx.doi.org/10.1016/s2221-1691(15)30160-x.

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17

Ben Eljia, L. la, A. is Hassine, A. Bouthouri, et al. "Neurobrucellosis whith meningoradiculopathy." Journal of the Neurological Sciences 357 (October 2015): e110. http://dx.doi.org/10.1016/j.jns.2015.08.353.

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18

da Mota, Henrique Carmona, M. H. Estev�o, L. M. Barosa, L. M. Matos, and A. A. Barroso. "Neurobrucellosis in children." European Journal of Pediatrics 154, no. 2 (1995): 120–22. http://dx.doi.org/10.1007/s004310050260.

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19

Estevão, Maria Helena Lopes, Lina Maria Ferreira Winckler Barosa, Luisa Maria Abreu Freire Diogo Matos, Ângelo Augusto Barroso, and Henrique Carmona da Mota. "Neurobrucellosis in children." European Journal of Pediatrics 154, no. 2 (1995): 120–22. http://dx.doi.org/10.1007/bf01991914.

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20

Handattu, Koushik, Nalini Bhaskaranand, and Sandesh Bailur Kini. "Neurobrucellosis Mimicking Neurotuberculosis." Indian Journal of Pediatrics 85, no. 7 (2018): 574. http://dx.doi.org/10.1007/s12098-018-2669-1.

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21

Angelucci, Clotilde Beatrice, Roberto Giacominelli-Stuffler, Marina Baffoni, et al. "Cellular Prion Protein Expression in the Brain Tissue from Brucella ceti-Infected Striped Dolphins (Stenella coeruleoalba)." Animals 12, no. 10 (2022): 1304. http://dx.doi.org/10.3390/ani12101304.

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Brucella ceti, a zoonotic pathogen of major concern to cetacean health and conservation, is responsible for severe meningo-encephalitic/myelitic lesions in striped dolphins (Stenella coeruleoalba), often leading to their stranding and death. This study investigated, for the first time, the cellular prion protein (PrPc) expression in the brain tissue from B. ceti-infected, neurobrucellosis-affected striped dolphins. Seven B. ceti-infected, neurobrucellosis-affected striped dolphins, found stranded along the Italian coastline (6) and in the Canary Islands (1), were investigated, along with five
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22

Karaoglan, Ilkay, Aylin Akcali, Ayhan Ozkur, and Mustafa Namýduru. "Neurobrucellosis mimicking demyelinizating disorders." Annals of Saudi Medicine 28, no. 2 (2008): 148–49. http://dx.doi.org/10.5144/0256-4947.2008.148.

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23

Okuyucu, Esra, Serkan Yilmazer, Havva Ozlem Dede, Ismet Melek, and Taskin Duman. "A case of neurobrucellosis." Turkish Journal of Cerebrovascular Diseases 17, no. 2 (2011): 73–76. http://dx.doi.org/10.5505/tbdhd.2011.98698.

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24

Bajin, Munir Demir, Ozden Savas, Filiz Aslan, and Levent Sennaroglu. "Cochlear Implantation in Neurobrucellosis." Balkan Medical Journal 33, no. 1 (2016): 108–11. http://dx.doi.org/10.5152/balkanmedj.2015.15544.

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25

Millichap, J. Gordon. "Diagnostic Features of Neurobrucellosis." Pediatric Neurology Briefs 27, no. 7 (2013): 53. http://dx.doi.org/10.15844/pedneurbriefs-27-7-7.

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26

Patil, Supriya, and Meenakshi Narkhede. "Neurobrucellosis: a case report." International Journal of Research in Medical Sciences 2, no. 1 (2014): 353. http://dx.doi.org/10.5455/2320-6012.ijrms20140271.

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27

Hesseling, A. C., B. J. Marais, and M. F. Cotton. "A child with neurobrucellosis." Annals of Tropical Paediatrics 23, no. 2 (2003): 145–48. http://dx.doi.org/10.1179/027249303235002224.

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28

Guneri, E. Alpin, Gunay Kirkim, Bulent M. Serbetcioglu, Taner K. Erdag, and Ataman Guneri. "Cochlear Implantation in Neurobrucellosis." Otology & Neurotology 30, no. 6 (2009): 747–49. http://dx.doi.org/10.1097/mao.0b013e3181b285ec.

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29

SHAKIR, RAAD A., A. S. N. AL-DIN, G. F. ARAJ, A. R. LULU, A. R. MOUSA, and M. A. SAADAH. "CLINICAL CATEGORIES OF NEUROBRUCELLOSIS." Brain 110, no. 1 (1987): 213–23. http://dx.doi.org/10.1093/brain/110.1.213.

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30

Van den Enden, E., E. Vlieghe, R. Demeester, G. Ieven, H. Jansens, and L. Van den Hauwe. "A traveler with neurobrucellosis." Travel Medicine and Infectious Disease 7, no. 4 (2009): 215–18. http://dx.doi.org/10.1016/j.tmaid.2009.05.004.

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31

Anlar, F. Yaşar, Songül Yalçin, and Gülten Seçmeer. "PERSISTENT HYPOGLYCORRHACHIA IN NEUROBRUCELLOSIS." Pediatric Infectious Disease Journal 13, no. 8 (1994): 747. http://dx.doi.org/10.1097/00006454-199408000-00016.

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32

Trifiletti, Rosario R., Domenico A. Restivo, Piero Pavone, Salvatore Giuffrida, and Enrico Parano. "Diabetes insipidus in neurobrucellosis." Clinical Neurology and Neurosurgery 102, no. 3 (2000): 163–65. http://dx.doi.org/10.1016/s0303-8467(00)00089-5.

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33

Cooke, R. P. D., and N. J. Beeching. "Neurobrucellosis in the UK." Journal of Infection 58, no. 1 (2009): 88–89. http://dx.doi.org/10.1016/j.jinf.2008.11.006.

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34

Eatemadifar, M., and M. Shirzadi. "3-04-03 Neurobrucellosis." Journal of the Neurological Sciences 150 (September 1997): S141—S142. http://dx.doi.org/10.1016/s0022-510x(97)85536-0.

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35

Sanchez-Sousa, A., C. Torres, M. G. Campello, et al. "Serological diagnosis of neurobrucellosis." Journal of Clinical Pathology 43, no. 1 (1990): 79–81. http://dx.doi.org/10.1136/jcp.43.1.79.

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36

Kesav, Praveen, Manish Modi, Veenu Singla, Dheeraj Khurana, and Sudesh Prabhakar. "Kaleidoscopic presentation of neurobrucellosis." Journal of the Neurological Sciences 331, no. 1-2 (2013): 165–67. http://dx.doi.org/10.1016/j.jns.2013.05.026.

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37

Ata, Fateen, Zohaib Yousaf, Mohammad Khalid Sharif, and Ahmed Abdallah. "Demyelinating steroid-responsive neurobrucellosis." BMJ Case Reports 13, no. 3 (2020): e233798. http://dx.doi.org/10.1136/bcr-2019-233798.

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Young man with acute onset nausea, vomiting, joint pain, abdominal pain, fever and weight loss was found to have gait ataxia and positive Brucella titres. He deteriorated despite appropriate antibiotics and developed confusion and disorientation. Lumbar puncture revealed lymphocytosis with high protein and low glucose. MRI showed diffuse demyelination. Pulse steroids resulted in rapid clinical, biochemical and radiological recovery.
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38

Akcay, Halil İbrahim, Murat Kurtuncu, Senay Yidiz Celik, Tuncay Gunduz, and Mefkure Eraksoy. "Neurobrucellosis presenting with mania." Acta Neurologica Belgica 117, no. 1 (2016): 373–75. http://dx.doi.org/10.1007/s13760-016-0648-8.

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39

International, Journal of Medical Science and Innovative Research (IJMSIR). "Neurobrucellosis: A Case Series." International Journal of Medical Science and Innovative Research (IJMSIR) 9, no. 4 (2024): 79–88. https://doi.org/10.5281/zenodo.15429556.

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<strong>Introduction</strong> Brucellosis has been an important zoonotic<strong> </strong>disease globally. Since Brucella<em> </em>can infect and survive without inducing a massive inflammatory response, this Bacteria was labelled<strong> </strong>as &ldquo;stealth pathogen.&rdquo; Its protean and diverse<strong> </strong>clinical presentation can mimic other infectious<strong> </strong>and Non infectious diseases, posing challenges<strong> </strong>to physicians in reaching a diagnosis,<strong> </strong>and merited the label &ldquo;disease of mistakes&rdquo;. The complications of brucellosis
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40

Ibrahim, Ibrahim I., Mohammed O. Aqeeli, Mead R. Aljabri, and Ameen K. Tajuddin. "Uncommon presentation of neurobrucellosis." Neurosciences 30, no. 3 (2025): 241–46. https://doi.org/10.17712/nsj.2025.3.20240081.

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41

Lakhanpal, Vikas, Deependra Singh, Kiran Bhagwat, and Kamalesh Chakravarthy. "Encephalomyelitis with hearing loss: case report on neurobrucellosis." BMJ Case Reports 15, no. 5 (2022): e248226. http://dx.doi.org/10.1136/bcr-2021-248226.

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Neurobrucellosis is a zoonotic infection transmitted by infected animals or by contact with animal products and is an important health problem in resource-limited settings. In this case report, we present the case of a middle-aged man presenting with encephalomyelitis with hearing loss and diagnosed with neurobrucellosis based on imaging and serological tests. Because brucellosis infection is indolent, a high index of suspicion should be maintained in individuals presenting with fever, neurological signs and symptoms so that early management can prevent long-term neurological sequelae such as
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42

Davison, NJ, MP Dagleish, M. ten Doeschate, et al. "Meningoencephalitis in a common minke whale Balaenoptera acutorostrata associated with Brucella pinnipedialis and gamma-herpesvirus infection." Diseases of Aquatic Organisms 144 (May 27, 2021): 231–35. http://dx.doi.org/10.3354/dao03590.

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Fatal marine Brucella infections with histologic lesions specific to the central nervous system (CNS), known as neurobrucellosis, have been described in 5 species of odontocete cetaceans in the UK: striped dolphins Stenella coeruleoalba, Atlantic white-sided dolphins Lagenorhynchus acutus, short-beaked common dolphins Delphinus delphis, long-finned pilot whale Globicephala melas and Sowerby’s beaked whale Mesoplodon bidens. To date, these CNS lesions have only been associated with Brucella ceti ST26 and not with B. pinnipedialis, which is rarely isolated from cetaceans and, although commonly f
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43

Baldi, Pablo C., George F. Araj, Graciela C. Racaro, Jorge C. Wallach, and Carlos A. Fossati. "Detection of Antibodies to BrucellaCytoplasmic Proteins in the Cerebrospinal Fluid of Patients with Neurobrucellosis." Clinical Diagnostic Laboratory Immunology 6, no. 5 (1999): 756–59. http://dx.doi.org/10.1128/cdli.6.5.756-759.1999.

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ABSTRACT The diagnosis of human neurobrucellosis usually relies on the detection of antibodies to Brucella lipopolysaccharide (LPS) in cerebrospinal fluid (CSF) by agglutination tests or enzyme-linked immunosorbent assay (ELISA). Here we describe the detection of immunoglobulin G (IgG) to cytoplasmic proteins (CP) ofBrucella spp. by ELISA and Western blotting in seven CSF samples from five patients with neurobrucellosis. While IgG to CP (titers of 200 to 12,800) and IgG to LPS (800 to 6,400) were found in the CSF of these patients, these antibodies were not detected in CSF samples from two pat
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44

Thomas, Ratna, Mohan Kameswaran, Vel Murugan, and B. C. Okafor. "Sensorineural hearing loss in neurobrucellosis." Journal of Laryngology & Otology 107, no. 11 (1993): 1034–36. http://dx.doi.org/10.1017/s0022215100125198.

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AbstractA case of neurobrucellosis presenting to the otologist with sensorineural hearing loss (SNHL) as the predominant clinical feature is reported. The diagnostic features and treatment options are discussed and the need for prolonged combination treatment to prevent relapse and further deterioration of hearing stressed. SNHL in neurobrucellosis has hitherto been reported principally in neurology literature as something of an incidental finding and so escapes the attention of otologists. It is hoped that this report will alert otologists in areas where brucellosis is endemic to the need to
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45

Granados-Zapata, Andrés, María José Robles-Malagamba, Rocío González-Barrientos, et al. "Pathological Studies and Postmortem Computed Tomography of Dolphins with Meningoencephalomyelitis and Osteoarthritis Caused by Brucella ceti." Oceans 3, no. 2 (2022): 189–203. http://dx.doi.org/10.3390/oceans3020014.

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Cetacean neurobrucellosis is a common cause of strandings in Costa Rica diagnosed by serology, bacteriology, and histopathology. Pathological studies were performed on 18 dolphins. Twelve were scanned by postmortem computed tomography (PMCT) as a complementary tool for describing neurobrucellosis and osteoarticular alterations associated with Brucella ceti infections. The central nervous system (CNS) and the skeleton of five dolphins not infected with B ceti did not reveal alterations by PMCT scanning. Seven Brucella-infected dolphins showed at least bilateral ventriculomegaly associated with
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46

Shah, Irfan Ahmad, Yuman Kawoos, Bashir Ahmad Sanai, Stanzen Rabyang, and Dawood Banday. "Neurobrucellosis Presenting as Acute Psychosis." Journal of Neurosciences in Rural Practice 09, no. 04 (2018): 644–46. http://dx.doi.org/10.4103/jnrp.jnrp_16_18.

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ABSTRACTA 45-year-old female without any past or family history of psychiatric illness presented to the emergency department with complaints of abnormal behavior, irrelevant talking, restlessness, episodic crying, and decreased sleep of 2-day duration. On detailed interview, the attendants gave a history of an intermittent headache of 6-month duration and hearing impairment of 4-month duration. On investigation, her cerebrospinal fluid was reactive, and brucella titers were positive. She received appropriate treatment for 6 months and a short course of antipsychotics. Her symptoms settled, but
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47

Arica, Vefik, Murat Tutanc, Murat Altas, and Omer Evirgen. "Pediatric neuroBrucellosis associated with hydrocephalus." Journal of Pediatric Neurosciences 5, no. 2 (2010): 144. http://dx.doi.org/10.4103/1817-1745.76115.

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48

Güven, M. Bahadir, Bayram Cirak, Ahmet Kutluhan, and Serdar Ugras. "Pituitary abscess secondary to neurobrucellosis." Journal of Neurosurgery 90, no. 6 (1999): 1142. http://dx.doi.org/10.3171/jns.1999.90.6.1142.

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49

Guven, Tumer, Kenan Ugurlu, Onder Ergonul, et al. "Neurobrucellosis: Clinical and Diagnostic Features." Clinical Infectious Diseases 56, no. 10 (2013): 1407–12. http://dx.doi.org/10.1093/cid/cit072.

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50

T, Sreedevi, Naga Raghunandan Thota, Nagaraja V.T, and Muralidhar H. "A RARE CASE OF NEUROBRUCELLOSIS." Journal of Evidence Based Medicine and Healthcare 4, no. 19 (2017): 1116–18. http://dx.doi.org/10.18410/jebmh/2017/219.

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