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Journal articles on the topic 'Neurocognitive reorganization'

Author: Grafiati

Published: 31 May 2025

Last updated: 31 July 2025

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1

Thompson, Cynthia K. "Neurocognitive Recovery of Sentence Processing in Aphasia." Journal of Speech, Language, and Hearing Research 62, no. 11 (2019): 3947–72. http://dx.doi.org/10.1044/2019_jslhr-l-rsnp-19-0219.

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Purpose Reorganization of language networks in aphasia takes advantage of the facts that (a) the brain is an organ of plasticity, with neuronal changes occurring throughout the life span, including following brain damage; (b) plasticity is highly experience dependent; and (c) as with any learning system, language reorganization involves a synergistic interplay between organism-intrinsic (i.e., cognitive and brain) and organism-extrinsic (i.e., environmental) variables. A major goal for clinical treatment of aphasia is to be able to prescribe treatment and predict its outcome based on the neuro

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Mogensen, Jesper, and Morten Overgaard. "Reorganization of the connectivity between elementary functions as a common mechanism of phenomenal consciousness and working memory: from functions to strategies." Philosophical Transactions of the Royal Society B: Biological Sciences 373, no. 1755 (2018): 20170346. http://dx.doi.org/10.1098/rstb.2017.0346.

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In the present communication, phenomenal consciousness, access consciousness and the closely related concept of working memory are presented in the context of a neurocognitive model—the REF (reorganization of elementary functions) framework. The REF framework is based on connectionist networks within which the ‘units’ are advanced processing modules called elementary functions (EFs). In this framework, the focus is on dynamically changeable ‘strategies’—based on reorganizations of the connectivity between EFs—rather than on the more traditional ‘cognitive functions’. The background for the REF

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Valencia, S., N. Trujillo, S. Trujillo, et al. "Neurocognitive reorganization of emotional processing following a socio-cognitive intervention in Colombian ex-combatants." Social Neuroscience 15, no. 4 (2020): 398–407. http://dx.doi.org/10.1080/17470919.2020.1735511.

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Fuhrmann, Delia, Ivan L. Simpson-Kent, Joe Bathelt, et al. "A Hierarchical Watershed Model of Fluid Intelligence in Childhood and Adolescence." Cerebral Cortex 30, no. 1 (2019): 339–52. http://dx.doi.org/10.1093/cercor/bhz091.

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AbstractFluid intelligence is the capacity to solve novel problems in the absence of task-specific knowledge and is highly predictive of outcomes like educational attainment and psychopathology. Here, we modeled the neurocognitive architecture of fluid intelligence in two cohorts: the Centre for Attention, Leaning and Memory sample (CALM) (N = 551, aged 5–17 years) and the Enhanced Nathan Kline Institute—Rockland Sample (NKI-RS) (N = 335, aged 6–17 years). We used multivariate structural equation modeling to test a preregistered watershed model of fluid intelligence. This model predicts that w

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Roger, Elise, Cédric Pichat, Félix Renard, et al. "Multimodal assessment of language and memory reorganization: a proof of concept in two patients with drug‐resistant temporal lobe epilepsy." Epileptic Disorders 21, no. 5 (2019): 411–24. http://dx.doi.org/10.1684/epd.2019.1092.

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ABSTRACT Aims . We report two patients suffering from drug‐resistant temporal lobe epilepsy to show how their neuroplasticity can be apprehended using a multimodal, integrative and clinically relevant approach. Methods . This is a proof of concept based on using multimodal data including: (1) white matter structural connectivity (DTI) of the main tracts involved in language and memory; (2) neurophysiological biomarkers (fMRI‐BOLD signal and LI lateralization indices); and (3) cognitive scores as measured during the neuropsychological assessment. We characterized tri‐modal data for each patient

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Castaldi, Elisa, Camilla Bonaudo, Giuseppe Maduli, et al. "Neurocognitive Assessment of Mathematics-Related Capacities in Neurosurgical Patients." Brain Sciences 14, no. 1 (2024): 69. http://dx.doi.org/10.3390/brainsci14010069.

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A precise neuropsychological assessment is of the utmost importance for neurosurgical patients undergoing the surgical excision of cerebral lesions. The assessment of mathematical abilities is usually limited to arithmetical operations while other fundamental visuo-spatial aspects closely linked to mathematics proficiency, such as the perception of numerical quantities and geometrical reasoning, are completely neglected. We evaluated these abilities with two objective and reproducible psychophysical tests, measuring numerosity perception and non-symbolic geometry, respectively. We tested sixte

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Simpson-Kent, Ivan L., Delia Fuhrmann, Joe Bathelt, Jascha Achterberg, Gesa Sophia Borgeest, and Rogier A. Kievit. "Neurocognitive reorganization between crystallized intelligence, fluid intelligence and white matter microstructure in two age-heterogeneous developmental cohorts." Developmental Cognitive Neuroscience 41 (February 2020): 100743. http://dx.doi.org/10.1016/j.dcn.2019.100743.

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Jay, Sharon Marie, Tracy Melzer, and Deborah Snell. "129 Chronic Pain and Advanced MRI Techniques." Neurosurgery 64, CN_suppl_1 (2017): 229. http://dx.doi.org/10.1093/neuros/nyx417.129.

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Abstract INTRODUCTION Chronic Pain is a difficult entity to define and treat. The usual definition is that of pain that persists beyond expected healing period of 3–6 months. The pathophysiology, in particular changing neural connections, are still not widely agreed on. In recent years neuroimaging has shown evidence of structural reorganization and change. These new developments can further improve understanding of the brains plasticity and potentially new strategies to either help identify those experiencing acute pain at risk of transition to chronic pain, but also as a potential target for

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Hughes, Laura E., and James B. Rowe. "The Impact of Neurodegeneration on Network Connectivity: A Study of Change Detection in Frontotemporal Dementia." Journal of Cognitive Neuroscience 25, no. 5 (2013): 802–13. http://dx.doi.org/10.1162/jocn_a_00356.

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The neural response to unpredictable auditory events is suggested to depend on frontotemporal interactions. We used magnetoencephalography in patients with behavioral variant frontotemporal dementia to study change detection and to examine the impact of disease on macroscopic network connectivity underlying this core cognitive function. In patients, the amplitudes of auditory cortical responses to predictable standard tones were normal but were reduced for unpredictable deviant tones. Network connectivity, in terms of coherence among frontal, temporal, and parietal sources, was also abnormal i

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Zhang, Xuena, and Jie Li. "Actin reorganization in hippocampal neurons may play a role in early learning and memory impairment after propofol anesthesia in rats." Journal of International Medical Research 51, no. 5 (2023): 030006052311692. http://dx.doi.org/10.1177/03000605231169214.

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Objectives To observe changes in actin and dendritic spines in the hippocampus after propofol anesthesia, and to evaluate the role of these changes in subsequent learning impairment in both young (3-month-old) and aged (20-month-old) male rats. Methods The shuttle box test was used to evaluate learning from 1, 3, 7, or 14 days after anesthesia. Both F-actin content and dendritic spines in the hippocampal CA1 region were observed using immunofluorescent staining and western blot assays. Results The latency of the escape response was significantly prolonged until 7 days after anesthesia in the a

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Hryhorova, Irina Anatolevna, O. O. Teslenko, and L. V. Tykhonova. "CLINICAL AND PATHOGENETIC FEATURES OF MILD TRAUMATIC BRAIN INJURY DISTANT PERIOD." International Medical Journal, no. 4(104) (December 24, 2020): 55–59. http://dx.doi.org/10.37436/2308-5274-2020-4-10.

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Plastic and energetic reorganization of brain after its traumatic injury lasts for many years, and impaired adaptive neuroplasticity can lead to progressive development. In the long term, even with a minor injury, the organic neurological symptoms are mitigated and autonomic and psychopathological disorders come to the fore, which are the main cause of social and occupational maladaptation of patients. To identify and analyze the clinical and pathogenetic features of the long−term period of mild traumatic brain injury, 100 patients aged 20−60 years who underwent it 1−5 years ago were examined.

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Alatorre-Cruz, Graciela C., Thalía Fernández, Susana A. Castro-Chavira, Mauricio González-López, Sergio M. Sánchez-Moguel, and Juan Silva-Pereyra. "One-Year Follow-Up of Healthy Older Adults with Electroencephalographic Risk for Neurocognitive Disorder After Neurofeedback Training." Journal of Alzheimer's Disease 85, no. 4 (2022): 1767–81. http://dx.doi.org/10.3233/jad-215538.

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Background: In healthy older adults, excess theta activity is an electroencephalographic (EEG) predictor of cognitive impairment. In a previous study, neurofeedback (NFB) treatment reinforcing reductions theta activity resulted in EEG reorganization and cognitive improvement. Objective: To explore the clinical applicability of this NFB treatment, the present study performed a 1-year follow-up to determine its lasting effects. Methods: Twenty seniors with excessive theta activity in their EEG were randomly assigned to the experimental or control group. The experimental group received an auditor

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Hernandez, Arturo. "Bilingualism, brain and development: A neuroemergentist perspective." Journal of the Acoustical Society of America 152, no. 4 (2022): A236. http://dx.doi.org/10.1121/10.0016125.

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Neuroemergentism, (NM) is a novel framework which has sought to consider language development as involving the organization and reorganization of cognition and its underlying neural substrate. Work to support this framework comes from studies of language and cognitive development. In this talk, I will focus on two separate levels, the sensorimotor plasticity needed to adjust to new input and the cognitive flexibility needed to select between these competing sources of information. This talk will discuss both these levels with regard to the neurocognitive adaptations seen in bilinguals. This wi

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Danilov, Igor Val, Dace Medne, and Sandra Mihailova. "Natural Neurostimulation for Chronic Pain Management: A Case Series of 3 Patients with Dysmenorrhea and Menstrual Migraine." OBM Neurobiology 09, no. 03 (2025): 1–11. https://doi.org/10.21926/obm.neurobiol.2503290.

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Accumulating evidence suggests that chronic pain occurs in various disorders due to correlated processes of spontaneous cortical reorganization and dysregulation of cortical excitability in consciousness-related networks. This case series tracks three patients with chronic pain associated with the menstrual cycle treated by a novel non-invasive brain stimulation technique that applies qualities of the mother-fetus neurocognitive model. Previous research has shown that a low-frequency pulsed electromagnetic field and a complex acoustic wave from the mother’s heart contribute to the synchronizat

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Simpson-Kent, Ivan L., Delia Fuhrmann, Joe Bathelt, Jascha Achterberg, Gesa Sophia Borgeest, and Rogier A. Kievit. "Erratum to “Neurocognitive reorganization between crystallized intelligence, fluid intelligence and white matter microstructure in two age-heterogeneous developmental cohorts” [Dev. Cogn. Neurosci. 41 (2020) 100743]." Developmental Cognitive Neuroscience 42 (April 2020): 100769. http://dx.doi.org/10.1016/j.dcn.2020.100769.

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Westmacott, Robyn. "CE Workshop 03: Stroke in the Developing Brain: Mechanisms, Outcomes, and Intervention." Journal of the International Neuropsychological Society 29, s1 (2023): 2. http://dx.doi.org/10.1017/s1355617723000802.

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Abstract & Learning Objectives:Over the past 10-15 years, significant progress has been made in the diagnosis and treatment of pediatrics stroke. Accordingly, the focus of much research has turned to understanding factors that determine neurological and neuropsychological outcomes in this population. This Continuing Education (CE) course will start by defining key terms in the field of pediatric stroke and reviewing current understanding of epidemiology, pathophysiology, diagnosis, and medical treatment. Next, we will review recent neuropsychological literature on cognitive outcomes follow

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Ventura, Nina, Linda Douw, Diogo G. Correa, et al. "Increased posterior cingulate cortex efficiency may predict cognitive impairment in asymptomatic HIV patients." Neuroradiology Journal 31, no. 4 (2018): 372–78. http://dx.doi.org/10.1177/1971400918782327.

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Purpose Despite antiretroviral therapy, approximately half of individuals with human immunodeficiency virus (HIV) will develop HIV-associated neurocognitive disorder (HAND). Efficiency of brain networks is of great importance for cognitive functioning, since functional networks may reorganize or compensate to preserve normal cognition. This study aims to compare efficiency of the posterior cingulate cortex (PCC) between patients with and without HAND and controls. We hypothesize HAND negative (HAND–) patients will show higher PCC efficiency than HAND positive (HAND+) patients. Methods A total

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Higgins, Shannon, Andrew Lassman, Laura Lennihan, et al. "NCMP-05. LEFT BASAL GANGLIA/INTERNAL CAPSULE GLIOBLASTOMA WITH MEMORY LOSS FROM CONTRALATERAL RADIATION INDUCED VASCULOPATHIES." Neuro-Oncology 23, Supplement_6 (2021): vi148. http://dx.doi.org/10.1093/neuonc/noab196.578.

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Abstract INTRODUCTION Radiation induced cerebral vasculopathy encompasses a complex and broad range of effects such as ischemia, hemorrhage, vascular malformation, capillary telangiectasias, and large vessel stenosis caused by pathological reorganization of tissue after radiation exposure. Necrosis and inflammation induce damage and demyelinating changes to other vessels over the corresponding areas that may occur months to years after brain irradiation. Here we report an unusual case of hemorrhagic basal ganglia/internal capsule glioblastoma followed by contralateral basal ganglia/internal ca

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Williams, Riccardo, Silvia Andreassi, Marta Moselli, et al. "Relationship between Executive Functions, Social Cognition, and Attachment State of Mind in Adolescence: An Explorative Study." International Journal of Environmental Research and Public Health 20, no. 4 (2023): 2836. http://dx.doi.org/10.3390/ijerph20042836.

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Background: The passage from pre-adolescence to adolescence is presented as a turning point for the achievement of those abilities in social understanding as they commonly appear in adulthood. Developmental perspectives point to the possible role of neuro-cognitive maturation and social experiences to facilitate this growth. This paper has the goal to goalsto propose a valid and reliable measure of the new quantitative and qualitative advancements in social understanding occurring in the adolescent passage; relying on this, the research has two main objectives (a) to establish the associations

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Obolsky, Maximillian A., Humza Khan, Zachary J. Resch, et al. "74 The Impact of Motoric Dysfunction on Neuropsychological Test Performance Within an Electrical Injury Sample." Journal of the International Neuropsychological Society 29, s1 (2023): 67–68. http://dx.doi.org/10.1017/s1355617723001558.

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Objective:Victims of electrical injury (EI) often experience injuries to the peripheral nervous system and neuromuscular damage that may diminish motor function, such as flexibility/dexterity. These difficulties may continue after rehabilitation due to the reorganization of muscle afferent projections during peripheral nerve regeneration. Therefore, understanding how patients with a history of thermal burn injuries perform on motoric measures is necessary to explain the impact neuromuscular damage has on both motor and non-motor tests of cognition. However, no studies have examined the impact

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Kim, Hayom, Sung Hoon Kang, Soon Ho Kim, et al. "Drinking coffee enhances neurocognitive function by reorganizing brain functional connectivity." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-021-93849-7.

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AbstractThe purpose of this study was to identify the mechanisms underlying effects of coffee on cognition in the context of brain networks. Here we investigated functional connectivity before and after drinking coffee using graph-theoretic analysis of electroencephalography (EEG). Twenty-one healthy adults voluntarily participated in this study. The resting-state EEG data and results of neuropsychological tests were consecutively acquired before and 30 min after coffee consumption. Graph analyses were performed and compared before and after coffee consumption. Correlation analyses were conduc

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Supekar, Kaustubh, Hyesang Chang, Percy K. Mistry, Teresa Iuculano, and Vinod Menon. "Neurocognitive modeling of latent memory processes reveals reorganization of hippocampal-cortical circuits underlying learning and efficient strategies." Communications Biology 4, no. 1 (2021). http://dx.doi.org/10.1038/s42003-021-01872-1.

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AbstractEfficient memory-based problem-solving strategies are a cardinal feature of expertise across a wide range of cognitive domains in childhood. However, little is known about the neurocognitive mechanisms that underlie the acquisition of efficient memory-based problem-solving strategies. Here we develop, to the best of our knowledge, a novel neurocognitive process model of latent memory processes to investigate how cognitive training designed to improve children’s problem-solving skills alters brain network organization and leads to increased use and efficiency of memory retrieval-based s

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Li, Anqi, Xiaofeng Deng, Kexin Yuan, et al. "Functional network reorganization and memory impairment in unruptured brain arteriovenous malformations." Frontiers in Neuroscience 19 (April 9, 2025). https://doi.org/10.3389/fnins.2025.1568045.

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BackgroundBrain arteriovenous malformations (AVMs) are congenital vascular anomalies that can affect cognitive, particularly memory functions. However, the underlying mechanisms of neurocognitive abnormalities in unruptured AVMs remain unclear. This study aimed to explore spontaneous functional network reorganization associated with memory impairment in unruptured AVM patients using resting-state functional MRI (rsfMRI).MethodsUsing rsfMRI data, we compared functional activity and connectivity patterns between 25 AVM patients and healthy controls, including regional homogeneity (ReHo), fractio

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Das, Moumita, Vanshika Singh, Lucina Q. Uddin, Arpan Banerjee, and Dipanjan Roy. "Reconfiguration of Directed Functional Connectivity Among Neurocognitive Networks with Aging: Considering the Role of Thalamo-Cortical Interactions." Cerebral Cortex, November 30, 2020. http://dx.doi.org/10.1093/cercor/bhaa334.

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Abstract A complete picture of how subcortical nodes, such as the thalamus, exert directional influence on large-scale brain network interactions across age remains elusive. Using directed functional connectivity and weighted net causal outflow on resting-state fMRI data, we provide evidence of a comprehensive reorganization within and between neurocognitive networks (default mode: DMN, salience: SN, and central executive: CEN) associated with age and thalamocortical interactions. We hypothesize that thalamus subserves both modality-specific and integrative hub role in organizing causal weight

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Foesleitner, Olivia, Benjamin Sigl, Victor Schmidbauer, et al. "Language network reorganization before and after temporal lobe epilepsy surgery." Journal of Neurosurgery, July 2020, 1–9. http://dx.doi.org/10.3171/2020.4.jns193401.

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OBJECTIVEEpilepsy surgery is the recommended treatment option for patients with drug-resistant temporal lobe epilepsy (TLE). This method offers a good chance of seizure freedom but carries a considerable risk of postoperative language impairment. The extremely variable neurocognitive profiles in surgical epilepsy patients cannot be fully explained by extent of resection, fiber integrity, or current task-based functional MRI (fMRI). In this study, the authors aimed to investigate pathology- and surgery-triggered language organization in TLE by using fMRI activation and network analysis as well

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Chen, Yi-Ching, Yi-Ying Tsai, Gwo-Ching Chang, and Ing-Shiou Hwang. "Cortical reorganization to improve dynamic balance control with error amplification feedback." Journal of NeuroEngineering and Rehabilitation 19, no. 1 (2022). http://dx.doi.org/10.1186/s12984-022-00980-1.

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Abstract Background Error amplification (EA), virtually magnify task errors in visual feedback, is a potential neurocognitive approach to facilitate motor performance. With regional activities and inter-regional connectivity of electroencephalography (EEG), this study investigated underlying cortical mechanisms associated with improvement of postural balance using EA. Methods Eighteen healthy young participants maintained postural stability on a stabilometer, guided by two visual feedbacks (error amplification (EA) vs. real error (RE)), while stabilometer plate movement and scalp EEG were reco

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Forbes, Miriam K., Andrew Baillie, Philip J. Batterham, et al. "Reconstructing Psychopathology: A Data-Driven Reorganization of the Symptoms in the Diagnostic and Statistical Manual of Mental Disorders." Clinical Psychological Science, October 17, 2024. http://dx.doi.org/10.1177/21677026241268345.

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In this study, we reduced the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders ( DSM-5) to its constituent symptoms and reorganized them based on patterns of covariation in individuals’ ( N = 14,762) self-reported experiences of the symptoms to form an empirically derived hierarchical framework of clinical phenomena. Specifically, we used the points of agreement among hierarchical principal components analyses and hierarchical clustering as well as between the randomly split primary ( n = 11,762) and hold-out ( n = 3,000) samples to identify the robust constructs that

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Zhu, Yakun, Weiqiang Gong, Xuesong Lu, and Haixian Wang. "Effective connectivity analysis of brain networks of mathematically gifted adolescents using transfer entropy." Journal of Intelligent & Fuzzy Systems, March 28, 2023, 1–12. http://dx.doi.org/10.3233/jifs-223819.

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Using functional neuroimaging, electrophysiological techniques and neural data processing techniques, neuroscientists have found that mathematically gifted adolescents exhibit unusual neurocognitive features in the activation of task-related brain regions. Hemispheric information interaction, functional reorganization of networks, and utilization of task-related brain regions are beneficial to rapid and efficient task processing. Based on Granger causality channel selection, the transfer entropy (TE) value between effective channels was computed, and the information flow patterns in the direct

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Bañuelos, C., J. R. Kittleson, K. H. LaNasa, et al. "Cognitive Aging and the Primate Basal Forebrain Revisited: Disproportionate GABAergic Vulnerability Revealed." Journal of Neuroscience, October 5, 2023, JN—RM—0456–23. http://dx.doi.org/10.1523/jneurosci.0456-23.2023.

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Basal forebrain (BF) projections to the hippocampus and cortex are anatomically positioned to influence a broad range of cognitive capacities that are known to decline in normal aging, including executive function and memory. Although a long history of research on neurocognitive aging has focused on the role of the cholinergic basal forebrain system, intermingled GABAergic cells are numerically as prominent and well-positioned to regulate the activity of their cortical projection targets, including the hippocampus and prefrontal cortex. The effects of aging on non-cholinergic BF neurons in pri

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Antal, Botond, Liam P. McMahon, Syed Fahad Sultan, et al. "Type 2 diabetes mellitus accelerates brain aging and cognitive decline: Complementary findings from UK Biobank and meta-analyses." eLife 11 (May 24, 2022). http://dx.doi.org/10.7554/elife.73138.

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Background:Type 2 diabetes mellitus (T2DM) is known to be associated with neurobiological and cognitive deficits; however, their extent, overlap with aging effects, and the effectiveness of existing treatments in the context of the brain are currently unknown.Methods:We characterized neurocognitive effects independently associated with T2DM and age in a large cohort of human subjects from the UK Biobank with cross-sectional neuroimaging and cognitive data. We then proceeded to evaluate the extent of overlap between the effects related to T2DM and age by applying correlation measures to the sep

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Maurer, Sara V., Cuicui Kong, Niccolò Terrando, and Christina L. Williams. "Dietary Choline Protects Against Cognitive Decline After Surgery in Mice." Frontiers in Cellular Neuroscience 15 (December 14, 2021). http://dx.doi.org/10.3389/fncel.2021.671506.

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Perioperative neurocognitive disorders (PNDs) are a common complication following procedures such as orthopedic surgery. Using a mouse model of tibial fracture and repair surgery, we have previously shown an increase in neuroinflammation and hippocampal-dependent cognitive deficits. These changes were ameliorated with the addition of a cholinergic agonist. Here, we sought to examine the effects of a high-choline diet for 3 weeks prior to tibial fracture surgery. We evaluated memory using novel object recognition (NOR) as well as young neurons and glial cell morphology at 1 day and 2 weeks post

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Kohta, Masaaki, Atsushi Fujita, Kohkichi Hosoda, and Eiji Kohmura. "Abstract WP474: Improvement of Cognitive Function and Reorganization of Brain Networks Following Carotid Endarterectomy and Carotid Artery Stenting." Stroke 51, Suppl_1 (2020). http://dx.doi.org/10.1161/str.51.suppl_1.wp474.

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Background: Internal carotid artery stenosis (ICS) can lead to cognitive impairment as well as ischemic stroke. Although carotid revascularization surgery, such as carotid endarterectomy (CEA) and carotid artery stenting (CAS), can prevent future strokes, the effect of revascularization on cognitive function is controversial. In this study, we examined the resting-state functional connectivity (FC) in ICS patients undergoing revascularization surgery, with a special focus on the Default Mode Network (DMN). Methods: We prospectively enrolled 24 ICS patients, who were expecting the intervention

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Nono, Alex S. T., Marco Anziano, Michael Mouthon, Joelle N. Chabwine, and Lucas Spierer. "The Role of Anatomic Connectivity in Inhibitory Control Revealed by Combining Connectome-based Lesion-symptom Mapping with Event-related Potentials." Brain Topography, June 10, 2024. http://dx.doi.org/10.1007/s10548-024-01057-z.

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AbstractInhibitory control refers to the ability to suppress cognitive or motor processes. Current neurocognitive models indicate that this function mainly involves the anterior cingulate cortex and the inferior frontal cortex. However, how the communication between these areas influence inhibitory control performance and their functional response remains unknown. We addressed this question by injecting behavioral and electrophysiological markers of inhibitory control recorded during a Go/NoGo task as the ‘symptoms’ in a connectome-based lesion-symptom mapping approach in a sample of 96 first

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Lacombe, Guy, Marie‐Pier Legresley, Michael Stiffel, and Suzanne Gosselin. "Quebec Eastern Township Regional Dementia Care Update after COVID. Reorganisation for the Quebec Ministerial Alzheimer program." Alzheimer's & Dementia 20, S4 (2024). https://doi.org/10.1002/alz.093027.

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AbstractBackgroundIn the province of Quebec, Canada, primary care management of Alzheimer’s disease is provided by the Family Medicine Group with the support of the Ministerial Initiative on Alzheimer’s Disease and the collaboration of specialized memory clinics. The COVID years have severely strained health resources in all areas, including cognitive intervention resources. We describe the reorganization of regional support in the Eastern Townships.MethodThe results of a survey on the situation of care are shared with each of the family medicine groups involved in the Eastern Townships Alzhei

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Hu, Yule, Yan Li, Ran Tao, et al. "Effects and mechanisms of a home-based action observation and motor imagery intervention on cognitive function and depression in spinal cord injury: a pilot randomized controlled trial protocol." Frontiers in Neurology 16 (May 16, 2025). https://doi.org/10.3389/fneur.2025.1578323.

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BackgroundCognitive impairment and depression frequently occur after spinal cord injury (SCI) and adversely affect functional independence and quality of life. There is a lack of research in addressing this important area in SCI rehabilitation/care. The home-based Action Observation and Motor Imagery (AOMI), a form of neurorehabilitation, was developed grounded in theoretical foundations and practical evidence, rendering it especially suitable for adults with SCI. This study aims to evaluate the feasibility, acceptability, and preliminary effects of this innovative intervention on SCI adults’

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Xu, Fan, Juming Ma, Wei Wang, and Hongjun Li. "A longitudinal study of the brain structure network changes in HIV patients with ANI: combined VBM with SCN." Frontiers in Neurology 15 (April 17, 2024). http://dx.doi.org/10.3389/fneur.2024.1388616.

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BackgroundDespite the widespread adoption of combination antiretroviral therapy (cART) in managing HIV, the virus’s impact on the brain structure of patients remains significant. This study aims to longitudinally explore the persistent effects of HIV on brain structure, focusing on changes in gray matter volume (GMV) and structural covariance network (SCN) among patients at the Asymptomatic Neurocognitive Impairment (ANI) stage.MethodsThis research involved 45 HIV patients diagnosed with ANI and 45 demographically matched healthy controls (HCs). The participants were observed over a 1.5-year p

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Fox, Molly, Jennifer E. Bramen, Dayoon Kwon, et al. "Women’s history of breastfeeding is positively associated with post‐menopausal cognitive function." Alzheimer's & Dementia 20, S7 (2024). https://doi.org/10.1002/alz.091063.

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AbstractBackgroundWomen’s reproductive experiences may enact reorganization of physiological systems with lifelong health consequences. We test the hypothesis that women’s history of breastfeeding will be positively associated with neurocognitive benefits in post‐menopausal women. This hypothesis is justified by breastfeeding’s well‐established benefits for mothers’ glucose homeostasis, beta‐cell function, adipose tissue mobilization, and lipid metabolism, which would plausibly be beneficial for later‐life brain health.MethodThe Women’s Health Initiative (WHI) was a long‐term, large, US health

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Jakimovski, Dejan, Ryu P. Dorn, Megan Del Regno, et al. "Human restricted CHRFAM7A gene increases brain efficiency." Frontiers in Neuroscience 18 (April 22, 2024). http://dx.doi.org/10.3389/fnins.2024.1359028.

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IntroductionCHRFAM7A, a uniquely human fusion gene, has been associated with neuropsychiatric disorders including Alzheimer’s disease, schizophrenia, anxiety, and attention deficit disorder. Understanding the physiological function of CHRFAM7A in the human brain is the first step to uncovering its role in disease. CHRFAM7A was identified as a potent modulator of intracellular calcium and an upstream regulator of Rac1 leading to actin cytoskeleton reorganization and a switch from filopodia to lamellipodia implicating a more efficient neuronal structure. We performed a neurocognitive-MRI correla

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Sidhu, Abhijot Singh, Kaue T. N. Duarte, Talal H. Shahid, et al. "Age‐ and Sex‐Specific Patterns in Adult Brain Network Segregation." Human Brain Mapping 46, no. 4 (2025). https://doi.org/10.1002/hbm.70169.

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ABSTRACTThe human brain is organized into several segregated associative and sensory functional networks, each responsible for various aspects of cognitive and sensory processing. These functional networks become less segregated over the adult lifespan, possibly contributing to cognitive decline that is observed during advanced age. To date, a comprehensive understanding of decreasing network segregation with age has been hampered by (1) small sample sizes, (2) lack of investigation at different spatial scales, (3) the limited age range of participants, and more importantly (4) an inadequate c

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