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Journal articles on the topic 'Neurodegenerative Disease (ND)'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Goldsteins, Gundars, Vili Hakosalo, Merja Jaronen, Meike Hedwig Keuters, Šárka Lehtonen, and Jari Koistinaho. "CNS Redox Homeostasis and Dysfunction in Neurodegenerative Diseases." Antioxidants 11, no. 2 (2022): 405. http://dx.doi.org/10.3390/antiox11020405.

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A single paragraph of about 200 words maximum. Neurodegenerative diseases (ND), such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, pose a global challenge in the aging population due to the lack of treatments for their cure. Despite various disease-specific clinical symptoms, ND have some fundamental common pathological mechanisms involving oxidative stress and neuroinflammation. The present review focuses on the major causes of central nervous system (CNS) redox homeostasis imbalance comprising mitochondrial dysfunction and endoplasmic reticulum (ER) stress.

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2

Tringali, Cristina, and Paola Giussani. "Ceramide and Sphingosine-1-Phosphate in Neurodegenerative Disorders and Their Potential Involvement in Therapy." International Journal of Molecular Sciences 23, no. 14 (2022): 7806. http://dx.doi.org/10.3390/ijms23147806.

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Neurodegenerative disorders (ND) are progressive diseases of the nervous system, often without resolutive therapy. They are characterized by a progressive impairment and loss of specific brain regions and neuronal populations. Cellular and animal model studies have identified several molecular mechanisms that play an important role in the pathogenesis of ND. Among them are alterations of lipids, in particular sphingolipids, that play a crucial role in neurodegeneration. Overall, during ND, ceramide-dependent pro-apoptotic signalling is promoted, whereas levels of the neuroprotective spingosine

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3

Pérez-Hernández, Jesús, Víctor Javier Zaldívar-Machorro, David Villanueva-Porras, Elisa Vega-Ávila, and Anahí Chavarría. "A Potential Alternative against Neurodegenerative Diseases: Phytodrugs." Oxidative Medicine and Cellular Longevity 2016 (2016): 1–19. http://dx.doi.org/10.1155/2016/8378613.

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Neurodegenerative diseases (ND) primarily affect the neurons in the human brain secondary to oxidative stress and neuroinflammation. ND are more common and have a disproportionate impact on countries with longer life expectancies and represent the fourth highest source of overall disease burden in the high-income countries. A large majority of the medicinal plant compounds, such as polyphenols, alkaloids, and terpenes, have therapeutic properties. Polyphenols are the most common active compounds in herbs and vegetables consumed by man. The biological bioactivity of polyphenols against neurodeg

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4

Chen, Chuanzhe. "AI-Aided Diagnosis For Neurodegenerative Diseases: Prospects And Challenges." Transactions on Materials, Biotechnology and Life Sciences 3 (March 24, 2024): 66–72. http://dx.doi.org/10.62051/72thpj80.

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Neurodegenerative disease (ND) represents a chronic disease characterized by loss of neuron function and death, such as Alzheimer's disease, Parkinson's disease, etc. It’s difficult and complex to diagnose ND, due to the requirement for the synthesis of multiple biomarker data, such as genes, proteins, images, etc. The advent of artificial intelligence (AI) technology, particularly through machine learning (ML) and deep learning (DL) algorithms, introduces novel methodologies and tools for ND diagnosis. These methodologies extract pertinent information and patterns from massive, multidimension

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Nishida, Hana, Akihiro Takamiya, Shun Kudo, et al. "P65: Characteristics of refractory late-life depression in the prodromal phase of neurodegenerative diseases." International Psychogeriatrics 35, S1 (2023): 159–60. http://dx.doi.org/10.1017/s104161022300296x.

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Objective:Depression is common in neurodegenerative diseases, and a psychiatric diagnosis of late-life depression (LLD) may be changed to neurodegenerative disease during the follow-up period. The aim of this study was to identify clinical characteristics of LLD that might be prodromal state of neurodegenerative diseases.Methods:We conducted a retrospective chart review to collect data (registered between April 2012 and September 2022) from individuals who received electroconvulsive therapy (ECT) for their severe depressive episodes due to major depressive disorder (MDD) or bipolar disorder, w

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Meng, Kai, Haocheng Jia, Xiaoqing Hou, et al. "Mitochondrial Dysfunction in Neurodegenerative Diseases: Mechanisms and Corresponding Therapeutic Strategies." Biomedicines 13, no. 2 (2025): 327. https://doi.org/10.3390/biomedicines13020327.

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Neurodegenerative disease (ND) refers to the progressive loss and morphological abnormalities of neurons in the central nervous system (CNS) or peripheral nervous system (PNS). Examples of neurodegenerative diseases include Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS). Recent studies have shown that mitochondria play a broad role in cell signaling, immune response, and metabolic regulation. For example, mitochondrial dysfunction is closely associated with the onset and progression of a variety of diseases, including ND, cardiovascular diseases, di

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Seifan, Alon, Christine A. Ganzer, Krista Ryon, et al. "Detecting Non-cognitive Features of Prodromal Neurodegenerative Diseases." Current Aging Science 11, no. 4 (2019): 242–49. http://dx.doi.org/10.2174/1874609812666190204094233.

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Background: Prodromal Neurodegenerative Disease (ND) due to tauopathies such as Alzheimer’s Disease (AD) and Synucleinopathies (SN) such as Parkinson's Disease (PD) and Dementia with Lewy Bodies (DLB) present subtly. Although ND are considered cognitive disorders, in fact ND present with behavioral and even medical symptomatology years to decades prior to the onset of cognitive changes. Recognizing prodromal ND syndromes is a public health priority because ND is common, disabling and expensive. Diagnosing prodromal ND in real world clinical settings is challenging because ND of the same pathol

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Sini, Paola, Thi Bang Chau Dang, Milena Fais, et al. "Cyanobacteria, Cyanotoxins, and Neurodegenerative Diseases: Dangerous Liaisons." International Journal of Molecular Sciences 22, no. 16 (2021): 8726. http://dx.doi.org/10.3390/ijms22168726.

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The prevalence of neurodegenerative disease (ND) is increasing, partly owing to extensions in lifespan, with a larger percentage of members living to an older age, but the ND aetiology and pathogenesis are not fully understood, and effective treatments are still lacking. Neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis are generally thought to progress as a consequence of genetic susceptibility and environmental influences. Up to now, several environmental triggers have been associated with NDs, and recent studies suggest that some

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9

Przybyszewski, Andrzej W., Albert Śledzianowski, Artur Chudzik, Stanisław Szlufik, and Dariusz Koziorowski. "Machine Learning and Eye Movements Give Insights into Neurodegenerative Disease Mechanisms." Sensors 23, no. 4 (2023): 2145. http://dx.doi.org/10.3390/s23042145.

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Humans are a vision-dominated species; what we perceive depends on where we look. Therefore, eye movements (EMs) are essential to our interactions with the environment, and experimental findings show EMs are affected in neurodegenerative disorders (ND). This could be a reason for some cognitive and movement disorders in ND. Therefore, we aim to establish whether changes in EM-evoked responses can tell us about the progression of ND, such as Alzheimer’s (AD) and Parkinson’s diseases (PD), in different stages. In the present review, we have analyzed the results of psychological, neurological, an

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Franciotti, Raffaella, Pamela Pignatelli, Claudia Carrarini, et al. "Exploring the Connection between Porphyromonas gingivalis and Neurodegenerative Diseases: A Pilot Quantitative Study on the Bacterium Abundance in Oral Cavity and the Amount of Antibodies in Serum." Biomolecules 11, no. 6 (2021): 845. http://dx.doi.org/10.3390/biom11060845.

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Recent studies support the hypothesis that microbes can seed some Alzheimer’s disease (AD) cases, leading to inflammation and overproduction of amyloid peptides. Porphyromonas gingivalis (Pg) is a keystone pathogen of chronic periodontitis and has been identified as risk factor for the development and progression of AD. The present preliminary study aimed to quantify Pg abundance in neurodegenerative disease (ND) patients compared with neurologic patients without neurodegenerative disorders (no-ND) and healthy controls (HC) to determine possible association between Pg abundance and neurodegene

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Barber, Kimberly, Patricia Mendonca, and Karam F. A. Soliman. "The Neuroprotective Effects and Therapeutic Potential of the Chalcone Cardamonin for Alzheimer’s Disease." Brain Sciences 13, no. 1 (2023): 145. http://dx.doi.org/10.3390/brainsci13010145.

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Neurodegenerative diseases (ND) include a wide range of conditions that result from progressive damage to the neurons. Alzheimer’s disease (AD) is one of the most common NDs, and neuroinflammation and oxidative stress (OS) are the major factors in the development and progression of the disease. Many naturally occurring phytochemical compounds exhibit antioxidant and anti-inflammatory activities with potential neuroprotective effects. Several plant species, including Alpinia katsumadai and Alpinia conchigera, contain cardamonin (CD). CD (2′,4′-dihydroxy-6′methoxychalcone) has many therapeutic p

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Pérez-Carrión, María Dolores, and Inmaculada Posadas. "Dendrimers in Neurodegenerative Diseases." Processes 11, no. 2 (2023): 319. http://dx.doi.org/10.3390/pr11020319.

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Neurodegenerative diseases (NDs), such as Parkinson’s Disease (PD), Alzheimer’s Disease (AD), Multiple Sclerosis (MS) and amyotrophic lateral sclerosis (ALS), are characterized by progressive loss of structure or function of neurons. Current therapies for NDs are only symptomatic and long-term ineffective. This challenge has promoted the development of new therapies against relevant targets in these pathologies. In this review, we will focus on the most promising therapeutic approaches based on dendrimers (DDs) specially designed for the treatment and diagnosis of NDs. DDs are well-defined pol

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13

Hassan, Zurina, and Raghava N. Sriramaneni. "Insights of the pathophysiology of neurodegenerative diseases and the role of phytochemical compounds in its management." Neuroscience Research Notes 4, no. 3 (2021): 1–10. http://dx.doi.org/10.31117/neuroscirn.v4i3.77.

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A neurodegenerative disease (ND) is defined as an irreversible disorder in most cases, leading to progressive loss of neurons and intellectual abilities. ND can lead to fatality in most circumstances, and the elderly above the age of sixty-five (65) constitute the major risk category. The most common type of ND includes Alzheimer's disease (AD), and Parkinson's disease (PD). Other NDs are Huntington's disease (HD), motor neuron disease (MND), spinocerebellar ataxia (SCA), spinal muscular atrophy (SMA), and prion disease. ND strikes mainly in the middle to late life incidence expected to rise a

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Jo, Seong-Lae, Hyun Yang, Sang R. Lee, Jun H. Heo, Hye-Won Lee, and Eui-Ju Hong. "Curcumae Radix Decreases Neurodegenerative Markers through Glycolysis Decrease and TCA Cycle Activation." Nutrients 14, no. 8 (2022): 1587. http://dx.doi.org/10.3390/nu14081587.

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Neurodegenerative diseases (ND) are being increasingly studied owing to the increasing proportion of the aging population. Several potential compounds are examined to prevent neurodegenerative diseases, including Curcumae radix, which is known to be beneficial for inflammatory conditions, metabolic syndrome, and various types of pain. However, it is not well studied, and its influence on energy metabolism in ND is unclear. We focused on the relationship between ND and energy metabolism using Curcumae radix extract (CRE) in cells and animal models. We monitored neurodegenerative markers and met

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Godswill, Emmanson Emmanson, Ogunwale Fawas Abiodun, Chiamaka Mercy Ogboji, et al. "Investigating the Roles of Gut Microbiome in the Progression of Neurodegenerative Diseases: Alzheimer's, Parkinson's, and Amyotrophic Lateral Sclerosis (ALS)." International Neuropsychiatric Disease Journal 21, no. 3 (2024): 26–44. http://dx.doi.org/10.9734/indj/2024/v21i3433.

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Neurodegenerative diseases (NDs), such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and Amyotrophic Lateral Sclerosis (ALS), pose global health burdens due to their incurable and degenerative nature. Emerging evidence highlights the complex interplay between the gut microbiome and the central nervous system (CNS), revealing novel mechanisms of ND pathogenesis and progression. This review integrates current literature, correlation analyses, and inferential statistics to elucidate the impact of gut microbiome dysbiosis on NDs and identify potential diagnostic biomarkers and therapeutic

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Loffredo, Lorenzo, Evaristo Ettorre, Anna Maria Zicari, et al. "Oxidative Stress and Gut-Derived Lipopolysaccharides in Neurodegenerative Disease: Role of NOX2." Oxidative Medicine and Cellular Longevity 2020 (February 1, 2020): 1–7. http://dx.doi.org/10.1155/2020/8630275.

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Background. Neurodegenerative diseases (ND) as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis represent a growing cause of disability in the developed countries. The underlying physiopathology is still unclear. Several lines of evidence suggest a role for oxidative stress and NADPH oxidase 2 (NOX2) in the neuropathological pathways that lead to ND. Furthermore, recent studies hypothesized a role for gut microbiota in the neuroinflammation; in particular, lipopolysaccharide (LPS) derived from Gram-negative bacteria in the gut is believed to play a role in causing ND

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Mansor, Nur Izzati, Nuratiqah Azmi, King Hwa Ling, Rozita Rosli, Zurina Hassan, and Norshariza Nordin. "Prospective stem cell lines as in vitro neurodegenerative disease models for natural product research." Neuroscience Research Notes 2, no. 1 (2019): 16–30. http://dx.doi.org/10.31117/neuroscirn.v2i1.25.

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The use of in vitro model for screening pharmacological compounds or natural products has gained global interest. The choice of cells to be manipulated plays a vital role in coming up with the best-suited model for specific diseases, including neurodegenerative diseases (ND). A good in vitro ND model should provide appropriate morphological and molecular features that mimic ND conditions where it can be used to screen potential properties of natural products in addition to unravelling the molecular mechanisms of ND. In this mini review, we intend to demonstrate two prospective stem cell lines

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Tupler, Larry, Arseniy Yashkin, Masudul Hoque, Anatoliy Yashin, Igor Akushevich, and Eric Stallard. "DIFFERENCES IN COGNITIVE DECLINE DUE TO ALZHEIMER’S DISEASE, NEURODEGENERATIVE DISORDERS, AND TRAUMA." Innovation in Aging 7, Supplement_1 (2023): 852. http://dx.doi.org/10.1093/geroni/igad104.2746.

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Abstract Alzheimer’s disease (AD) is a form of progressive dementia associated with significant personal, social, and economic burdens, making targeted interventions aimed at mitigating the effects of this condition on cognitive decline highly desirable. However, AD is but one of a range Neurodegenerative Disorders (ND) classified as dementias of aging. Furthermore, neither AD/ ND nor cognitive decline itself are monolithic: each individual disorder degrades specific aspects of cognition at differing rates. Isolating the most vulnerable facet of good cognitive health associated with each condi

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Cebuc, Madalina, Lilia Rotaru, Adrian Lupusor, et al. "Circadian rhythm disruptions and neurodegeneration through Parkinson disease and cognitive disruptions." Bulletin of the Academy of Sciences of Moldova. Medical Sciences 74, no. 3 (2022): 10–15. http://dx.doi.org/10.52692/1857-0011.2022.3-74.01.

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Circadian rhythm disorders (CRD) result from modern lifestyles characterized by long exposure time to blue light, shift-work, chronic stress and night-time social activities. The disruption of circadian rhythms represents an individual risk factor in the development of various diseases, including neurodegenerative ones. Simultaneously, the demographic ageing is associated with the rising incidence of neurodegenerative diseases (ND), the cognitive decline becoming a societal problem. Thus, this literature review’s purpose is to outline the interconnexion between CRD – ND – cognitive disruptions

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Quan, XinRan, and Marica Bakovic. "Regulation of Membrane Phospholipid Homeostasis in Neurodegenerative Diseases." OBM Geriatrics 05, no. 03 (2020): 1. http://dx.doi.org/10.21926/obm.geriatr.2103176.

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Neurodegenerative diseases (NDs) are a diverse group of neuropathological diseases that are currently incurable due to the irreversible neuronal loss. At the present rate of the world population growth, it is projected that the number of ND cases will double by the year of 2050. With treatments only available for symptom management and relief, disease prevention may yield significant benefits. Recently, there had been association drawn between the disruption of phospholipid (PL) homeostasis and the progression of NDs. Pathological developments were observed in cellular processes including auto

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Gandla, Kumaraswamy, Ancha Kishore Babu, Aziz Unnisa, et al. "Carotenoids: Role in Neurodegenerative Diseases Remediation." Brain Sciences 13, no. 3 (2023): 457. http://dx.doi.org/10.3390/brainsci13030457.

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Numerous factors can contribute to the development of neurodegenerative disorders (NDs), such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Huntington’s disease, and multiple sclerosis. Oxidative stress (OS), a fairly common ND symptom, can be caused by more reactive oxygen species being made. In addition, the pathological state of NDs, which includes a high number of protein aggregates, could make chronic inflammation worse by activating microglia. Carotenoids, often known as “CTs”, are pigments that exist naturally and play a vital role in the prevention of seve

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Ye, Qiang, Yi Xia, and Zhiming Yao. "Classification of Gait Patterns in Patients with Neurodegenerative Disease Using Adaptive Neuro-Fuzzy Inference System." Computational and Mathematical Methods in Medicine 2018 (September 30, 2018): 1–8. http://dx.doi.org/10.1155/2018/9831252.

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A common feature that is typical of the patients with neurodegenerative (ND) disease is the impairment of motor function, which can interrupt the pathway from cerebrum to the muscle and thus cause movement disorders. For patients with amyotrophic lateral sclerosis disease (ALS), the impairment is caused by the loss of motor neurons. While for patients with Parkinson’s disease (PD) and Huntington’s disease (HD), it is related to the basal ganglia dysfunction. Previously studies have demonstrated the usage of gait analysis in characterizing the ND patients for the purpose of disease management.

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Quach, Tam T., Harrison J. Stratton, Rajesh Khanna, et al. "Neurodegenerative Diseases: From Dysproteostasis, Altered Calcium Signalosome to Selective Neuronal Vulnerability to AAV-Mediated Gene Therapy." International Journal of Molecular Sciences 23, no. 22 (2022): 14188. http://dx.doi.org/10.3390/ijms232214188.

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Despite intense research into the multifaceted etiology of neurodegenerative diseases (ND), they remain incurable. Here we provide a brief overview of several major ND and explore novel therapeutic approaches. Although the cause (s) of ND are not fully understood, the accumulation of misfolded/aggregated proteins in the brain is a common pathological feature. This aggregation may initiate disruption of Ca++ signaling, which is an early pathological event leading to altered dendritic structure, neuronal dysfunction, and cell death. Presently, ND gene therapies remain unidimensional, elusive, an

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Ferrero, Maria Elena. "Neuron Protection by EDTA May Explain the Successful Outcomes of Toxic Metal Chelation Therapy in Neurodegenerative Diseases." Biomedicines 10, no. 10 (2022): 2476. http://dx.doi.org/10.3390/biomedicines10102476.

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Many mechanisms have been related to the etiopathogenesis of neurodegenerative diseases (NDs) such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson’s disease, and Alzheimer’s disease. In this context, the detrimental role of environmental agents has also been highlighted. Studies focused on the role of toxic metals in the pathogenesis of ND demonstrate the efficacy of treatment with the chelating agent calcium disodium ethylenediaminetetraacetic acid (EDTA) in eliminating toxic metal burden in all ND patients, improving their symptoms. Lead, cadmium, aluminum, nickel, and mercur

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del Álamo-Gómez, Nuria, Estrella Montes-López, and Eva María Picado-Valverde. "461 - Social services for neurodegenerative patients and their families." International Psychogeriatrics 32, S1 (2020): 182. http://dx.doi.org/10.1017/s1041610220003130.

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Introduction:Neurodegenerative diseases (ND) are the most important cause of dependency in the world. The care of these patients is mostly assumed by their families. As a result, their family quality of life (FQoL) may be affected, decreasing their well-being, and modifying their habits and normal functioning. FQoL is a multidimensional concept, composed of different aspects that determine the life situation of each family, being these components both objective and subjective. Thus, the FQoL will depend on being able to access to support services that respond to the individual needs of all mem

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Cruz-Vicente, Pedro, Luís A. Passarinha, Samuel Silvestre, and Eugenia Gallardo. "Recent Developments in New Therapeutic Agents against Alzheimer and Parkinson Diseases: In-Silico Approaches." Molecules 26, no. 8 (2021): 2193. http://dx.doi.org/10.3390/molecules26082193.

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Neurodegenerative diseases (ND), including Alzheimer’s (AD) and Parkinson’s Disease (PD), are becoming increasingly more common and are recognized as a social problem in modern societies. These disorders are characterized by a progressive neurodegeneration and are considered one of the main causes of disability and mortality worldwide. Currently, there is no existing cure for AD nor PD and the clinically used drugs aim only at symptomatic relief, and are not capable of stopping neurodegeneration. Over the last years, several drug candidates reached clinical trials phases, but they were suspend

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Koletis, Adam, Pavlos Bitilis, Nikolaos Zafeiropoulos, and Konstantinos Kotis. "Can Semantics Uncover Hidden Relations between Neurodegenerative Diseases and Artistic Behaviors?" Applied Sciences 13, no. 7 (2023): 4287. http://dx.doi.org/10.3390/app13074287.

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Semantics play a crucial role in organizing domain knowledge, schematizing it, and modeling it into classes of objects and relationships between them. Knowledge graphs (KGs) use semantic models to integrate and represent different types of data. This study aimed to systematically review related work on the topics of ontologies for neurodegenerative diseases (NDs), ontology-based expert systems for NDs, and the artistic behavior of ND patients. The utilization of ontologies allows for a more comprehensive understanding of the progression and etiology of NDs, the structure and function of the br

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Lero, Christi, Soobin Park, and Emily Mroz. "SELF-COMPASSION IN CAREGIVERS OF NEURODEGENERATIVE DISEASES: DEMENTIA CARE CONTEXTS AND BEYOND." Innovation in Aging 8, Supplement_1 (2024): 874–75. https://doi.org/10.1093/geroni/igae098.2828.

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Abstract Informal caregivers of those with neurodegenerative disease (ND) manage increasingly complex symptoms which impact their own wellbeing. Self-compassion can promote maintenance of wellbeing during challenging life experiences, including caregiving. There is little guidance for studying self-compassion observationally or targeting self-compassion through intervention for this population. Our objective was to complete a scoping review of research describing self-compassion in the context of wellbeing of informal caregivers of those living with ND. In this review, following PRISMA-ScR gui

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Shi, Qian, Shuqian Liu, Vivian A. Fonseca, Tina K. Thethi, and Lizheng Shi. "Effect of metformin on neurodegenerative disease among elderly adult US veterans with type 2 diabetes mellitus." BMJ Open 9, no. 7 (2019): e024954. http://dx.doi.org/10.1136/bmjopen-2018-024954.

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ObjectiveThis study aimed to evaluate the association between metformin treatment and the risk of neurodegenerative disease (ND) among elderly adults with type 2 diabetes mellitus (T2DM).Design/Setting/ParticipantsThis retrospective longitudinal cohort study examined the effects of the length of metformin exposure on ND among elderly US veterans with T2DM and insulin treatment using the Veterans Affairs electronic medical record database.Primary and secondary outcome measuresThe primary clinical outcome was defined as diagnosis of ND including dementia, Alzheimer’s disease (AD), Parkinson’s di

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Bonanni, Roberto, Ida Cariati, Pierangelo Cifelli, et al. "Exercise to Counteract Alzheimer’s Disease: What Do Fluid Biomarkers Say?" International Journal of Molecular Sciences 25, no. 13 (2024): 6951. http://dx.doi.org/10.3390/ijms25136951.

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Neurodegenerative diseases (NDs) represent an unsolved problem to date with an ever-increasing population incidence. Particularly, Alzheimer’s disease (AD) is the most widespread ND characterized by an accumulation of amyloid aggregates of beta-amyloid (Aβ) and Tau proteins that lead to neuronal death and subsequent cognitive decline. Although neuroimaging techniques are needed to diagnose AD, the investigation of biomarkers within body fluids could provide important information on neurodegeneration. Indeed, as there is no definitive solution for AD, the monitoring of these biomarkers is of st

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Zhou, Jiaxin, Wenfen Zhang, Zhiwen Cao, et al. "Association of Selenium Levels with Neurodegenerative Disease: A Systemic Review and Meta-Analysis." Nutrients 15, no. 17 (2023): 3706. http://dx.doi.org/10.3390/nu15173706.

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Background: Neurodegenerative diseases (NDs) have posed significant challenges to public health, and it is crucial to understand their mechanisms in order to develop effective therapeutic strategies. Recent studies have highlighted the potential role of selenium in ND pathogenesis, as it plays a vital role in maintaining cellular homeostasis and preventing oxidative damage. However, a comprehensive analysis of the association between selenium and NDs is still lacking. Method: Five public databases, namely PubMed, Web of Science, EMBASE, Cochrane and Clinical Trials, were searched in our resear

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Motta, Vinicius, Nick Zabinyakov, Qanber Raza, et al. "Single-cell analysis using Imaging Mass Cytometry spatially resolves immune activity in neurodegenerative brain pathology." Journal of Immunology 212, no. 1_Supplement (2024): 0594_5488. http://dx.doi.org/10.4049/jimmunol.212.supp.0594.5488.

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Abstract Immune response plays a significant role in the progression of neurodegenerative diseases (NDs) such as Parkinson’s disease (PD), Alzheimer’s disease (AD), and multiple sclerosis (MS). It is paramount to quantify the immune and structural spatial microenvironment of ND brain using research approaches that resolve tissue at a single-cell level. Imaging Mass Cytometry™ (IMC™) is a spatial biology technique that provides quantitative phenotypic evaluation of 40-plus markers. We report the application of two new IMC imaging modes with 40-marker panels for ND research. Tissue mode (TM) was

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Esposito, Sonia, Alessandra Masala, Simona Sanna, et al. "Redox-sensitive GFP to monitor oxidative stress in neurodegenerative diseases." Reviews in the Neurosciences 28, no. 2 (2017): 133–44. http://dx.doi.org/10.1515/revneuro-2016-0041.

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AbstractRedox processes are key events in the degenerative cascade of many adult-onset neurodegenerative diseases (NDs), but the biological relevance of a single redox change is often dependent on the redox couple involved and on its subcellular origin. The biosensors based on engineered fluorescent proteins (redox-sensitive GFP [roGFP]) offer a unique opportunity to monitor redox changes in both physiological and pathological contexts in living animals and plants. Here, we review the use of roGFPs to monitor oxidative stress in different three adult-onset NDs: Alzheimer’s disease (AD), Parkin

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Bachurin, Sergey O., Elena F. Shevtsova, Galina F. Makhaeva, et al. "Conjugates of Methylene Blue with Cycloalkaneindoles as New Multifunctional Agents for Potential Treatment of Neurodegenerative Disease." International Journal of Molecular Sciences 23, no. 22 (2022): 13925. http://dx.doi.org/10.3390/ijms232213925.

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The development of multi-target-directed ligands (MTDLs) would provide effective therapy of neurodegenerative diseases (ND) with complex and nonclear pathogenesis. A promising method to create such potential drugs is combining neuroactive pharmacophoric groups acting on different biotargets involved in the pathogenesis of ND. We developed a synthetic algorithm for the conjugation of indole derivatives and methylene blue (MB), which are pharmacophoric ligands that act on the key stages of pathogenesis. We synthesized hybrid structures and performed a comprehensive screening for a specific set o

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Rastogi, Simran, Vaibhav Sharma, Prahalad Singh Bharti, et al. "The Evolving Landscape of Exosomes in Neurodegenerative Diseases: Exosomes Characteristics and a Promising Role in Early Diagnosis." International Journal of Molecular Sciences 22, no. 1 (2021): 440. http://dx.doi.org/10.3390/ijms22010440.

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Neurodegenerative diseases (ND) remains to be one of the biggest burdens on healthcare systems and serves as a leading cause of disability and death. Alzheimer’s disease (AD) is among the most common of such disorders, followed by Parkinson’s disease (PD). The basic molecular details of disease initiation and pathology are still under research. Only recently, the role of exosomes has been linked to the initiation and progression of these neurodegenerative diseases. Exosomes are small bilipid layer enclosed extracellular vesicles, which were once considered as a cellular waste and functionless.

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Ma, Kaige, Chenglin Zhang, Hanyue Zhang, et al. "High-Salt Diet Accelerates Neuron Loss and Anxiety in APP/PS1 Mice Through Serpina3n." International Journal of Molecular Sciences 25, no. 21 (2024): 11731. http://dx.doi.org/10.3390/ijms252111731.

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High salt (HS) consumption is an independent risk factor for neurodegenerative diseases such as dementia, stroke, and cerebral small vessel disease related to cognitive decline. Recently, Alzheimer’s disease-like pathology changes have been reported as consequences of a HS diet in wild-type (wt) mice. However, it has not been revealed how HS diets accelerate the progress of Alzheimer’s disease (AD) in APP/PS1 mice. Here, we fed APP/PS1 mice a HS diet or normal diet (ND) for six months; the effects of the HS/ND on wt mice were also observed. The results of our behavior test reveal that the HS d

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Aza, Alba, María G. Vela, María G. Vela, Eva González, Isabel Vicario-Molina, and María Begoña Orgaz y Marta Badia. "406 - Supports received by the families of people with neurodegenerative disease: a quantitative and qualitative approach." International Psychogeriatrics 33, S1 (2021): 32–33. http://dx.doi.org/10.1017/s1041610221001654.

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Introduction:When neurodegenerative disease (ND) is diagnosed, the family’s quality of life (FQoL) changes drastically. Within the concept of FQoL, the supports they receive from others at the community level and from services is one of the most important issues. Nonetheless, studies available using a mixed-methods approach are still limited. Consequently, the objective was to study the domains of support from services and support from others (emotional and practical), through the application of a quantitative instrument and the conduction of focus groups.Method:Three hundred relatives of peop

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Adeyemi, Oluyomi Stephen, Oluwakemi Josephine Awakan, Lawrence Boluwatife Afolabi, et al. "Hypoxia and the Kynurenine Pathway: Implications and Therapeutic Prospects in Alzheimer’s Disease." Oxidative Medicine and Cellular Longevity 2021 (November 10, 2021): 1–11. http://dx.doi.org/10.1155/2021/5522981.

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Neurodegenerative diseases (NDs) like Alzheimer’s disease, multiple sclerosis, amyotrophic lateral sclerosis, Parkinson’s disease, and Huntington’s disease predominantly pose a significant socioeconomic burden. Characterized by progressive neural dysfunction coupled with motor or intellectual impairment, the pathogenesis of ND may result from contributions of certain environmental and molecular factors. One such condition is hypoxia, characterized by reduced organ/tissue exposure to oxygen. Reduced oxygen supply often occurs during the pathogenesis of ND and the aging process. Despite the well

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Sultana T, Safiya, Rupali D. Mitra, Jyotsna Gawai, and Sudhanshu Singh. "Impact of Exosomes Serving as a Tool for Nano-Science in Neurotherapeutics: Anti-Alzheimers." SAMRIDDHI : A Journal of Physical Sciences, Engineering and Technology 13, SUP 1 (2021): 7–9. http://dx.doi.org/10.18090/samriddhi.v13is1.3.

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Alzheimer’s disease, being a chronic state progressive ND(neurodegenerative diseases), is characterised by abnormalities beta-amyloid and impaired cognitive functions resulting in dementia. Exosomes (Nano-particles) have developed as a promising mediators of NDs in which they carry toxic particles between cells and transfer them. Hence, current review focusesprimarily on the effects of exosomes in modulating mediators and promotingneuroprotection against NDs.

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Donohue, Cara, Yassin Khalifa, Shitong Mao, Subashan Perera, Ervin Sejdić, and James L. Coyle. "Characterizing Swallows From People With Neurodegenerative Diseases Using High-Resolution Cervical Auscultation Signals and Temporal and Spatial Swallow Kinematic Measurements." Journal of Speech, Language, and Hearing Research 64, no. 9 (2021): 3416–31. http://dx.doi.org/10.1044/2021_jslhr-21-00134.

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Purpose The prevalence of dysphagia in patients with neurodegenerative diseases (ND) is alarmingly high and frequently results in morbidity and accelerated mortality due to subsequent adverse events (e.g., aspiration pneumonia). Swallowing in patients with ND should be continuously monitored due to the progressive disease nature. Access to instrumental swallow evaluations can be challenging, and limited studies have quantified changes in temporal/spatial swallow kinematic measures in patients with ND. High-resolution cervical auscultation (HRCA), a dysphagia screening method, has accurately di

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Song, Jaeyoon, Eunseo Cho, Huiseop Lee, Suyoung Lee, Sehyeon Kim, and Jinsik Kim. "Development of Neurodegenerative Disease Diagnosis and Monitoring from Traditional to Digital Biomarkers." Biosensors 15, no. 2 (2025): 102. https://doi.org/10.3390/bios15020102.

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Monitoring and assessing the progression of symptoms in neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are critical for improving patient outcomes. Traditional biomarkers, such as cerebrospinal fluid analysis and brain imaging, are widely used to investigate the underlying mechanisms of disease and enable early diagnosis. In contrast, digital biomarkers derived from phenotypic changes—such as EEG, eye movement, gait, and speech analysis—offer a noninvasive and accessible alternative. Leveraging portable and widely available devices, such as smartphones and wearable

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Silva-García, Octavio, Ricarda Cortés-Vieyra, Francisco N. Mendoza-Ambrosio, Guillermo Ramírez-Galicia та Víctor M. Baizabal-Aguirre. "GSK3α: An Important Paralog in Neurodegenerative Disorders and Cancer". Biomolecules 10, № 12 (2020): 1683. http://dx.doi.org/10.3390/biom10121683.

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The biological activity of the enzyme glycogen synthase kinase-3 (GSK3) is fulfilled by two paralogs named GSK3α and GSK3β, which possess both redundancy and specific functions. The upregulated activity of these proteins is linked to the development of disorders such as neurodegenerative disorders (ND) and cancer. Although various chemical inhibitors of these enzymes restore the brain functions in models of ND such as Alzheimer’s disease (AD), and reduce the proliferation and survival of cancer cells, the particular contribution of each paralog to these effects remains unclear as these molecul

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Anant, Prakash Pandey, and Kumar Shukla Santosh. "Polyphenol based novel drug delivery carriers for the treatment of ageing related neurodegenerative disorder: a modern approach." International Journal of Advances in Pharmacy Medicine and Bioallied Sciences 10, no. 2 (2022): 76–81. https://doi.org/10.5281/zenodo.7046004.

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The main risk factor for the emergence and spread of neurodegenerative disorders (ND) is age. The growth in ND prevalence, particularly in emerging nations, is thought to be mostly caused by the expansion of longevity. The challenge for doctors and researchers is to find treatment approaches able to slow down neurodegeneration and/or improve the patient's quality of life because there is currently no cure for any of them. Increased cellular oxidative stress has been identified as one of the potential risk factors in ND, along with genetics and environmental stresses. The antioxidant effect

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Iyaswamy, Ashok, Kejia Lu, Xin-Jie Guan, et al. "Impact and Advances in the Role of Bacterial Extracellular Vesicles in Neurodegenerative Disease and Its Therapeutics." Biomedicines 11, no. 7 (2023): 2056. http://dx.doi.org/10.3390/biomedicines11072056.

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Bacterial Extracellular Vesicles (BEVs) possess the capability of intracellular interactions with other cells, and, hence, can be utilized as an efficient cargo for worldwide delivery of therapeutic substances such as monoclonal antibodies, proteins, plasmids, siRNA, and small molecules for the treatment of neurodegenerative diseases (NDs). BEVs additionally possess a remarkable capacity for delivering these therapeutics across the blood–brain barrier to treat Alzheimer’s disease (AD). This review summarizes the role and advancement of BEVs for NDs, AD, and their treatment. Additionally, it in

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Gao, Yan, Yaoping Lu, Xiaojing Liang, et al. "CD4+ T-Cell Senescence in Neurodegenerative Disease: Pathogenesis and Potential Therapeutic Targets." Cells 13, no. 9 (2024): 749. http://dx.doi.org/10.3390/cells13090749.

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With the increasing proportion of the aging population, neurodegenerative diseases have become one of the major health issues in society. Neurodegenerative diseases (NDs), including multiple sclerosis (MS), Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS), are characterized by progressive neurodegeneration associated with aging, leading to a gradual decline in cognitive, emotional, and motor functions in patients. The process of aging is a normal physiological process in human life and is accompanied by the aging of the immune system, which is known a

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Chudzik, Artur, Albert Śledzianowski, and Andrzej W. Przybyszewski. "Machine Learning and Digital Biomarkers Can Detect Early Stages of Neurodegenerative Diseases." Sensors 24, no. 5 (2024): 1572. http://dx.doi.org/10.3390/s24051572.

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Neurodegenerative diseases (NDs) such as Alzheimer’s Disease (AD) and Parkinson’s Disease (PD) are devastating conditions that can develop without noticeable symptoms, causing irreversible damage to neurons before any signs become clinically evident. NDs are a major cause of disability and mortality worldwide. Currently, there are no cures or treatments to halt their progression. Therefore, the development of early detection methods is urgently needed to delay neuronal loss as soon as possible. Despite advancements in Medtech, the early diagnosis of NDs remains a challenge at the intersection

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Vallée, Alexandre, Jean-Noël Vallée та Yves Lecarpentier. "Parkinson’s Disease: Potential Actions of Lithium by Targeting the WNT/β-Catenin Pathway, Oxidative Stress, Inflammation and Glutamatergic Pathway". Cells 10, № 2 (2021): 230. http://dx.doi.org/10.3390/cells10020230.

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Parkinson’s disease (PD) is one of the major neurodegenerative diseases (ND) which presents a progressive neurodegeneration characterized by loss of dopamine in the substantia nigra pars compacta. It is well known that oxidative stress, inflammation and glutamatergic pathway play key roles in the development of PD. However, therapies remain uncertain and research for new treatment is mandatory. This review focuses on the potential effects of lithium, as a potential therapeutic strategy, on PD and some of the presumed mechanisms by which lithium provides its benefit properties. Lithium medicati

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Agnello, Luisa, Caterina Maria Gambino, Anna Maria Ciaccio, et al. "Molecular Biomarkers of Neurodegenerative Disorders: A Practical Guide to Their Appropriate Use and Interpretation in Clinical Practice." International Journal of Molecular Sciences 25, no. 8 (2024): 4323. http://dx.doi.org/10.3390/ijms25084323.

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Neurodegenerative disorders (NDs) represent a group of different diseases characterized by the progressive degeneration and death of the nervous system’s cells. The diagnosis is challenging, especially in the early stages, due to no specific clinical signs and symptoms. In this context, laboratory medicine could support clinicians in detecting and differentiating NDs. Indeed, biomarkers could indicate the pathological mechanisms underpinning NDs. The ideal biofluid for detecting the biomarkers of NDs is cerebrospinal fluid (CSF), which has limitations, hampering its widespread use in clinical

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Kershenovich, Amir, Angela V. Price, Korgun Koral, Stan Goldman, and Dale M. Swift. "Failure to treat obstructive hydrocephalus with endoscopic third ventriculostomy in a patient with neurodegenerative Langerhans cell histiocytosis." Journal of Neurosurgery: Pediatrics 2, no. 5 (2008): 304–9. http://dx.doi.org/10.3171/ped.2008.2.11.304.

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The second most frequent central nervous system involvement pattern in Langerhans cell histiocytosis (LCH) is a rare condition documented in a number of reports called “neurodegenerative LCH” (ND-LCH). Magnetic resonance images confirming the presence of the disease usually demonstrate striking symmetric bilateral hyperintensities predominantly in the cerebellum, basal ganglia, pons, and/or cerebral white matter. The authors here describe for the first time in the literature a patient with ND-LCH and concomitant hydrocephalus initially treated using endoscopic third ventriculostomy (ETV). This

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Robinson, John L., Sharon X. Xie, Daniel R. Baer, et al. "Pathological combinations in neurodegenerative disease are heterogeneous and disease-associated." Brain, March 2, 2023. http://dx.doi.org/10.1093/brain/awad059.

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Abstract Pathologies that are causative for neurodegenerative disease (ND) are also frequently present in unimpaired, older individuals. In this retrospective study of 1,647 autopsied individuals, we report the incidence of ten pathologies across ND and normal ageing in attempt to clarify which pathological combinations are disease-associated and which are ageing-related. Eight clinically defined groups were examined including unimpaired individuals and those with clinical Alzheimer’s disease, mixed dementia, amyotrophic lateral sclerosis, frontotemporal degeneration, multiple system atrophy,

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