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Journal articles on the topic 'Neuroendocrine-immune complex'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Popovych, Igor, Igor Bombushkar, Xawery Żukow, and Halyna Kovalchuk. "Uric acid, neuroendocrine-immune complex and metabolism: relationships." Journal of Education, Health and Sport 36, no. 1 (2023): 135–59. http://dx.doi.org/10.12775/jehs.2023.36.01.013.

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Background. During the implementation of the project "Physiological activity of uric acid", our group discovered four variants of the combination of levels of uricemia and uricosuria in patients with chronic pyelonephritis in the remission phase, which are accompanied by characteristic constellations of parameters of the central and autonomic nervous, endocrine, and immune systems, as well as the exchange of nitrogenous metabolites and electrolytes, the levels of which correlate with uricemia and/or uricosuria. The aim of this study is to clarify the relationship between parameters of uric aci

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Deckx, Nathalie, Wai-Ping Lee, Zwi N. Berneman, and Nathalie Cools. "Neuroendocrine Immunoregulation in Multiple Sclerosis." Clinical and Developmental Immunology 2013 (2013): 1–23. http://dx.doi.org/10.1155/2013/705232.

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Currently, it is generally accepted that multiple sclerosis (MS) is a complex multifactorial disease involving genetic and environmental factors affecting the autoreactive immune responses that lead to damage of myelin. In this respect, intrinsic or extrinsic factors such as emotional, psychological, traumatic, or inflammatory stress as well as a variety of other lifestyle interventions can influence the neuroendocrine system. On its turn, it has been demonstrated that the neuroendocrine system has immunomodulatory potential. Moreover, the neuroendocrine and immune systems communicate bidirect

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POPOVYCH, I. L., І. S. POLOVYNKO, L. M. ZAJATS, and O. I. MELNYK. "Sexual Dimorphism of the Neuroendocrine-Immune Complex and its Reactions to Chronic Stress in Rats." Experimental and Clinical Physiology and Biochemistry 2018, no. 3 (2018): 5–17. http://dx.doi.org/10.25040/ecpb2018.03.005.

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Marfiyan, O. M., T. A. Korolyshyn, L. G. Barylyak, et al. "Neuroendocrine-immune and metabolic accompaniments of cholecystokinetic effects of balneotherapy on SPA Truskavets’." Journal of Education, Health and Sport 5, no. 5 (2015): 21–30. https://doi.org/10.5281/zenodo.17307.

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<strong>Marfiyan O</strong> <strong>M, Korolyshyn T</strong> <strong>A, Barylyak L</strong> <strong>G, </strong><strong>Kovbasnyuk M M, </strong><strong>Yavors’kyi O</strong> <strong>V,</strong> <strong>Zukow W,</strong> <strong>Popovych I</strong> <strong>L</strong><strong>. </strong><strong>Neuroendocrine-immune and metabolic accompaniments of cholecystokinetic effects of balneotherapy on SPA Truskavets’</strong><strong>. </strong><strong>Journal of Education, Health and Sport. </strong><strong>2015;5(5):21-30. ISSN 2391-8306. DOI: </strong><strong>10.5281/zenodo.17307</strong> <

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Murzenok, Petr, and Vitaly Goranov. "Do local immune-neuroendocrine disturbances initiate diabetes?" Canadian Journal of Physiology and Pharmacology 77, no. 3 (1999): 147–55. http://dx.doi.org/10.1139/y99-012.

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It has been suggested that there exists a local immune-neuroendocrine self-regulating system in the pancreas. The system consists of β-cells, nerve ganglia, intercellular fluid, connective tissue, and endothelial and immunocompetent cells. The local immune-neuroendocrine system governs the background level of insulin production by intrinsic mechanisms both in normal conditions and in a recovery period after different kinds of stress. The activity of this system by a complex of metabolic, environmental, nerve, and nonspecific immune factors has been determined. The local immune-neuroendocrine s

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Tuchscherer, M., and G. Manteuffel. "Die Wirkung von psychischem Streß auf das Immunsystem. Ein weiterer Grund für tiergerechte Haltung (Übersichtsreferat)." Archives Animal Breeding 43, no. 6 (2000): 547–60. http://dx.doi.org/10.5194/aab-43-547-2000.

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Abstract. Title of the paper: The effect of psycho stress on the immune System. Another reason for pursuing animal welfare (Review) Stress can be seen as the body's most important and complex reaction to ensure survival. Thus, stress must be considered a fundamentally positive type of adaptive reaction and concepts of stress have to be integral parts in considering animal well-being. It is widely recognized that acute and chronic stress have an impact on the neuroendocrine and immune system, the latter being of special interest with respect to health and welfare of animals. This review intends

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Hrytsak, Myroslava, Dariya Popovych, Nataliya Badiuk, Ivanna Hrytsan, and Xawery Żukow. "Comparative study of the effect on the neuroendocrine-immune complex and metabolism of drinking monotherapy with Naftussya water and therapy supplemented with “Myroslava” and “Khrystyna” mineral waters." Journal of Education, Health and Sport 12, no. 1 (2022): 355–67. http://dx.doi.org/10.12775/jehs.2022.12.01.031.

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Background. Earlier in an experiment on rats, we showed that the newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’ spa have neuroendocrine and metabolic effects significantly different from daily water. Adhering to the principle "From experiment to clinic", we continued research in this direction with the participation of patients of the resort. Materials and Methods. The object of clinical-physiological observation were 34 men aged 23-70 years, who underwent rehabilitation treatment of chronic cholecystitis and pyelonephritis in remission in the Truskavets

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Hrytsak, Myroslava, Dariya Popovych, Sofiya Ruzhylo, Nataliya Zakalyak, and Walery Zukow. "Neuro-endocrine mechanism of specific balneoeffects of sulfate-chloride sodium-magnesium mineral waters." Journal of Education, Health and Sport 12, no. 3 (2022): 274–82. http://dx.doi.org/10.12775/jehs.2022.12.03.023.

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Background. Earlier we showed that the newly created sulfate-chloride sodium-magnesium drinking mineral waters “Myroslava” (5 g/L) and “Khrystyna” (10 g/L) have favorable effects on neuroendocrine-immune complex and metabolism of patients with their violations. At the same time, the influence of both waters on one constellation of parameters is similar, despite the twofold difference in mineralization, while on the other constellation it is different. The aim of this study was to elucidate the neuroendocrine mechanism of specific effects. Materials and Methods. The object of clinical-physiolog

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Steullet, Pascal. "Editorial for the Special Issue “Oxidative Stress, Inflammation and Antioxidant Defense System in Psychiatric Disorders” in Antioxidants (2022–2023)." Antioxidants 13, no. 11 (2024): 1307. http://dx.doi.org/10.3390/antiox13111307.

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A growing body of evidence indicates that many genetic and environmental factors associated with psychiatric disorders affect redox homeostasis, mitochondria and energy metabolism, and neuroendocrine and immune systems in a complex synergistic manner, leading to oxidative stress and inflammation [...]

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Popovych, Daria, Nataliya Badiuk, Myroslava Hrytsak, Sofiya Ruzhylo, Oksana Mel’nyk, and Xawery Zukow. "Sulfate-chloride sodium-magnesium mineral waters modulate neuroendocrine-immune complex and metabolism in healthy female rats." Journal of Education, Health and Sport 11, no. 12 (2021): 455–66. http://dx.doi.org/10.12775/jehs.2021.11.12.037.

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Background. Earlier in an experiment on rats, we showed that newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’ spa has a significant modulating effect on the parameters of metabolism and the autonomic nervous, endocrine and immune systems. In this study, we combined data obtained on the same animals, in line with the concepts of neuroendocrine-immune complex and functional-metabolic continuum. Materials and Methods. Experiment was performed on 50 healthy female Wistar rats 230-290 g divided into 4 groups. Animals of the first group remained intact, using ta

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You, Jiulin, Liangshu Feng, Meiying Xin, Di Ma, and Jiachun Feng. "Cerebral Ischemic Postconditioning Plays a Neuroprotective Role through Regulation of Central and Peripheral Glutamate." BioMed Research International 2018 (July 19, 2018): 1–12. http://dx.doi.org/10.1155/2018/6316059.

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Following cerebral ischemia/reperfusion (I/R) injury, a series of pathophysiological processes are stimulated in both the central nervous system (CNS) and the periphery, including, but not limited to, the peripheral immune and endocrine systems and underregulation of the neuroendocrine-immune network. Glutamate (Glu) is an important excitatory neurotransmitter in the CNS; its excitotoxicity following cerebral ischemia has been a focus of study for several decades. In addition, as a novel immunoregulator, Glu also regulates immune activity in both the CNS and periphery and may connect the CNS a

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Ottaviani, E., A. Franchini, and S. Genedani. "ACTH and its Role in Immune-neuroendocrine Functions. A Comparative Study." Current Pharmaceutical Design 5, no. 9 (1999): 673–81. http://dx.doi.org/10.2174/1381612805666230111194256.

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Adrenocorticotropic hormone (ACTH) belongs to the melanocortine group of related peptides which share a common precursor, the pro-opiomelanocortin (POMC). Melanocortin expresses its functional effects by the stimulation of specific G-protein coupled receptors. To date, five receptor subtypes have been cloned. The POMC gene has been highly conserved during evolution, and ACTH has been found in different cells from invertebrates to vertebrates to vertebrates, including man. Witµ regards the immune system, the presence of melanocortin receptors and the production of ACTH have been reported in inv

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Wang, Yu-Qing, Qi Liu, Yan Zhou, et al. "Stage-Specific Transcriptomes of the Mussel Mytilus coruscus Reveals the Developmental Program for the Planktonic to Benthic Transition." Genes 14, no. 2 (2023): 287. http://dx.doi.org/10.3390/genes14020287.

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Many marine invertebrate larvae undergo complex morphological and physiological changes during the planktonic—benthic transition (a.k.a. metamorphosis). In this study, transcriptome analysis of different developmental stages was used to uncover the molecular mechanisms underpinning larval settlement and metamorphosis of the mussel, Mytilus coruscus. Analysis of highly upregulated differentially expressed genes (DEGs) at the pediveliger stage revealed enrichment of immune-related genes. The results may indicate that larvae co-opt molecules of the immune system to sense and respond to external c

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Houseknecht, K. L. "Leptin and its receptors: Modulation of the neuroendocrine axis." Proceedings of the British Society of Animal Science 2002 (2002): 229. http://dx.doi.org/10.1017/s1752756200008851.

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Leptin is a 16 kDa protein synthesized and secreted primarily by adipocytes. Leptin was discovered in 1994 as the gene product deficient in the obese ob/ob mouse. In addition to profound obesity, these animals are characterized by multiple, complex neuroendocrine disorders that manifest in severe insulin resistance and infertility. We now know that leptin is involved in the regulation of appetite, body weight, energy balance, reproduction and the neuroendocrine axis in animals and man. Additionally, leptin has been shown to regulate immune function and anorexia associated with disease.

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Babelyuk, Valeriy, Ruslan Tserkovniuk, Nazariy Babelyuk, et al. "The parameters of gas discharge visualization (biophotonics) correlated with parameters of acupuncture points, EEG, HRV and hormones." Journal of Education, Health and Sport 11, no. 12 (2021): 359–73. http://dx.doi.org/10.12775/jehs.2021.11.12.030.

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Background. Previously we have been shown that exist strong canonical correlation between parameters of GDV and principal neuroendocrine factors of adaptation as well as parameters of leukocytogram, immunity and phagocytosis. This study, conducted on a much expanded contingent, will analyze the relationships between GDV parameters, on the one hand, and the parameters of acupuncture points (APs), EEG, HRV and adaptation hormones, on the other. Material and Methods. We observed twice 31 women and 29 men aged 26-76 years with dysfunction of neuroendocrine-immune complex. In the morning in basal c

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Liu, Zhaoqun, Zhi Zhou, Qiufen Jiang, et al. "The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas." Open Biology 7, no. 1 (2017): 160289. http://dx.doi.org/10.1098/rsob.160289.

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The neuroendocrine-immune (NEI) regulatory network is a complex system, which plays an indispensable role in the immunity of host. In this study, a neuroendocrine immunomodulatory axis (NIA)-like pathway mediated by the nervous system and haemocytes was characterized in the oyster Crassostrea gigas . Once invaded pathogen was recognized by the host, the nervous system would temporally release neurotransmitters to modulate the immune response. Instead of acting passively, oyster haemocytes were able to mediate neuronal immunomodulation promptly by controlling the expression of specific neurotra

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Marfiyan, Olena M., and Walery Zukow. "Relationships between parameters of gall-bladder motility and neuroendocrine-immune complex and metabolism in men with chronic cholecystitis and pyelonephritis." Journal of Education, Health and Sport 5, no. 12 (2015): 434–49. https://doi.org/10.5281/zenodo.35660.

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<strong>Marfiyan Olena M</strong><strong>, </strong><strong>Zukow Walery. Relationships between p</strong><strong>a</strong><strong>rame</strong><strong>t</strong><strong>e</strong><strong>rs</strong> <strong>of gall-bladder motility and neuroendocrine-immune complex and metabolism in</strong><strong> men with </strong><strong>chronic cholecystitis and pyelonephritis. </strong><strong>Journal of Education, Health and Sport. </strong><strong>2015;5(12):434-449. ISSN 2391-8306. DOI</strong> <strong>http://dx.doi.org/10.5281/zenodo.35660</strong> <strong>http://ojs.ukw.edu.pl/index.php/johs/artic

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Gozhenko, Anatoliy, Myroslava Hrytsak, Dariya Popovych, Nataliya Badiuk, and Xawery Żukow. "“Myroslava” and “Khrystyna” drinking mineral waters modulate the state of neuroendocrine-immune complex and metabolism in patients of Truskavets’ spa." Journal of Education, Health and Sport 12, no. 3 (2022): 11–23. http://dx.doi.org/10.12775/jehs.2022.12.03.001.

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Background. Earlier in an experiment on rats we showed that newly created sulfate-chloride sodium-magnesium drinking mineral waters "Myroslava" and "Khrystyna" of Truskavets’ spa has a significant modulating effects on the parameters of metabolism and the autonomic nervous, endocrine and immune systems. Adhering to the principle "Ex experimento ad clinic", we continued research in this direction with the participation of patients of the resort. We showed that these mineral waters have favorable effects on metabolic, HRVs, EEGs, endocrine and immune parameters. This article presents an integrat

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Popovych, Andriy, Igor Popovych, Dariya Popovych, Sofiya Ruzhylo, and Xawery Żukow. "Relationships between changes in the state of neuroendocrine regulation and immunity in patients of Truskavets’ spa." Journal of Education, Health and Sport 11, no. 6 (2021): 335–47. http://dx.doi.org/10.12775/jehs.2021.11.06.036.

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Background. Earlier we showed that the balneotherapeutic complex of Truskavets’ spa have significant modulating effects on parameters of EEG&HRV and Immunity of patients with chronic pyelonephritis and cholecystitis in remission accompanied of neuroendocrine-immune complex dysfunction. Were detected the close relationships between EEG, HRV, endocrine and immune parameters as well as between changes in EEG&HRV and immune parameters under the influence of balneotherapy. The aim of this study was to analyze the relationships between changes in the state of neuroendocrine regulation and im

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Popovych, Igor, Anatoliy Gozhenko, Myroslava Hrytsak, Dariya Popovych, Nataliya Badiuk, and Walery Zukow. "Peculiarities of modulating effects of “Myroslava” and “Khrystyna” mineral waters on neuroendocrine-immune complex and metabolism in patients of Truskavets’ spa." Journal of Education, Health and Sport 12, no. 3 (2022): 53–66. http://dx.doi.org/10.12775/jehs.2022.12.03.005.

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Background. Earlier we found effects on the neuroendocrine-immune complex and metabolism, which are common to the mineral waters "Myroslava" and "Khrystyna", instead different from the effects of Naftussya water. The purpose of this article is to find the specific effects of these waters. Materials and Methods. The object of clinical-physiological observation were 22 men aged 23-70 years, who underwent rehabilitation treatment of chronic cholecystitis and pyelonephritis in remission in the Truskavets’ spa. The examination was performed twice, before and after a 7-10-day course of balneotherapy

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Plyska, Oleksandr, Alyona Vorobienko, Roman Yanchii, and Xawery Żukow. "Neuroendocrine-immune relationships at rats regardless of sex and exposure to stressors or adaptogens." Journal of Education, Health and Sport 47, no. 1 (2023): 133–54. http://dx.doi.org/10.12775/jehs.2023.47.01.013.

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Introduction and aim. Since the discovery of the famous Selye triad, studies of the connections between adaptation hormones and the immune system have remained relevant. We formulated the aim of the future study: in the mode of synchronicity, to reveal sexual differences in the parameters of the neuroendocrine-immune complex and the state of neuroendocrine-immune relationships in intact rats and exposed to stressors and adaptogens. This article initiates the beginning of the movement towards achieving the goal. Material and methods. The experiment is at 96 rats Wistar line: 48 males and 48 fem

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Griffis, Charles A., Peggy Compton, and Lynn Doering. "The Effect of Pain on Leukocyte Cellular Adhesion Molecules." Biological Research For Nursing 7, no. 4 (2006): 297–312. http://dx.doi.org/10.1177/1099800405286071.

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The psychophysiological phenomenon of pain is of tremendous concern to nurses because of its potential to adversely affect the mental, emotional, and physical health of patients. Increasingly appreciated is the ability of pain to influence immune variables including enumerative and functional measures of leukocyte subsets. In this review, a theoretical model of the role of pain in producing positive changes in the expression of leukocyte cellular adhesion molecules is developed. The model is based on a conceptualization of pain as a perturbing influence on the complex web of neuroendocrine-imm

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Montgomery, Richard Murdoch. "Molecular Mechanisms of Chronic Stress in Immune Dysregulation: From Cytokine Networks to Clinical Manifestations." Wired Neuroscience 1, no. 12 (2024): 24–53. https://doi.org/10.62162/wnsc10609.2.

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This article examines the intricate molecular mechanisms linking chronic stress to immune system dysregulation, with particular emphasis on cytokine networks and their role in disease development. Recent advances in molecular immunology have revealed sophisticated pathways through which persistent stress influences immune function, leading to various pathological conditions. We analyze the complex interactions between neuroendocrine responses and immune regulation, focusing on how stress-induced alterations in cytokine networks affect both innate and adaptive immunity. The article integrates f

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Popovych, Igor, Igor Kuchma, Sofiya Ruzhylo, Walery Zukow, and Anatoliy Gozhenko. "Neuroendocrine-immune complex as the mirror of the state of exchange of nitrogenous metabolites at rats." Journal of Education, Health and Sport 11, no. 8 (2021): 55–65. http://dx.doi.org/10.12775/jehs.2021.11.08.006.

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Background. Earlier we found that even in intact rats, certain parameters of nitrogenous metabolism fluctuate in a fairly wide range, which further expands in cases of prolonged water loads. Based on this, we have been created three groups that are homogeneous in the parameters of nitrogenous metabolism. We have been shown that each cluster is accompanied by a specific constellation of immune parameters. In this study, an attempt will be made to supplement the immune accompaniment of each constellation of nitrogenous metabolites with parameters of the autonomic nervous and endocrine systems. M

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Kaufman, Jacob, Doug Cress, Theresa Boyle, David Carbone, Neal Ready, and Kris Wood. "909 Differentiation subgroups within LKB1-deficient lung cancer influence both the immune exclusion phenotype and cellular composition of the immune microenvironment." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A954—A955. http://dx.doi.org/10.1136/jitc-2021-sitc2021.909.

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BackgroundLKB1 (STK11) is a commonly disrupted tumor suppressor in NSCLC. Its loss promotes an immune exclusion phenotype with evidence of low expression of interferon stimulated genes (ISG) and decreased microenvironment immune infiltration.1 2 Clinically, LKB1 loss induces primary immunotherapy resistance.3 LKB1 is a master regulator of a complex downstream kinase network and has pleiotropic effects on cell biology. Understanding the heterogeneous phenotypes associated with LKB1 loss and their influence on tumor-immune biology will help define and overcome mechanisms of immunotherapy resista

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Navarro-Ledesma, Santiago. "Frozen Shoulder as a Metabolic and Immune Disorder: Potential Roles of Leptin Resistance, JAK-STAT Dysregulation, and Fibrosis." Journal of Clinical Medicine 14, no. 5 (2025): 1780. https://doi.org/10.3390/jcm14051780.

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Frozen shoulder (FS) is a complex and multifactorial condition characterized by persistent inflammation, fibrosis, and metabolic dysregulation. Despite extensive research, the underlying drivers of FS remain poorly understood. Recent findings indicate the coexistence of pro-inflammatory and fibrosis-resolving macrophages within affected tissues, suggesting a dysregulated immune response influenced by metabolic and neuroendocrine factors. This review proposes that leptin resistance, a hallmark of metabolic syndrome and chronic inflammation, may play a central role in FS pathogenesis by impairin

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Popadynets', Oleksandr O., Volodymyra R. Bilas, Igor-Severyn S. Flyunt, et al. "Features of the condition of the neuroendocrine-immune complex in different constellations of entropies of morpho-functional immune subsystems in rats." Journal of Education, Health and Sport 10, no. 8 (2020): 214–29. https://doi.org/10.12775/JEHS.2020.10.08.025.

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<strong>Popadynets</strong><strong>’</strong><strong> Oleksandr</strong> <strong>O</strong><strong>., </strong><strong>B</strong><strong>i</strong><strong>l</strong><strong>as </strong><strong>Volodymyra</strong> <strong>R</strong><strong>., </strong><strong>Fl</strong><strong>y</strong><strong>u</strong><strong>nt </strong><strong>Igor</strong><strong>-</strong><strong>Severyn</strong> <strong>S</strong><strong>., </strong><strong>Ba</strong><strong>d</strong><strong>i</strong><strong>uk </strong><strong>Nataliya</strong> <strong>S</strong><strong>., </strong><s

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Sekaninova, Nikola, Lucia Bona Olexova, Zuzana Visnovcova, Igor Ondrejka, and Ingrid Tonhajzerova. "Role of Neuroendocrine, Immune, and Autonomic Nervous System in Anorexia Nervosa-Linked Cardiovascular Diseases." International Journal of Molecular Sciences 21, no. 19 (2020): 7302. http://dx.doi.org/10.3390/ijms21197302.

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Anorexia nervosa represents a severe mental disorder associated with food avoidance and malnutrition. In patients suffering from anorexia nervosa, cardiovascular complications are the main reason leading to morbidity and mortality. However, the origin and pathological mechanisms leading to higher cardiovascular risk in anorexia nervosa are still unclear. In this aspect, the issue of exact pathological mechanisms as well as sensitive biomarkers for detection of anorexia nervosa-linked cardiovascular risk are discussed. Therefore, this review synthesised recent evidence of dysfunction in multipl

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Popovych, Igor, Anatoliy Gozhenko, Myroslava Hrytsak, et al. "General non-specific effects of balneofactors of Truskavets’ spa on parameters of neuroendocrine regulation, metabolism, immunity and microbiota in patients with chronic pyelonephritis and cholecystitis." Journal of Education, Health and Sport 12, no. 1 (2022): 368–84. http://dx.doi.org/10.12775/jehs.2022.12.01.032.

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Background. Earlier in experiments on rats, it was shown that drinking mineral water, regardless of their mineralization and chemical composition, have similar (nonspecific) course effects on a number of parameters of metabolism and neuroendocrine-immune complex. The aim of this study is to identify such parameters in patients of Truskavets’ spa who received complex drinking balneotherapy. Materials and Methods. The object of clinical-physiological observation were 34 men aged 23-70 years, who underwent rehabilitation treatment of chronic cholecystitis and pyelonephritis in remission. The exam

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Popovych, Igor L., Igor L. Kuchma, Sofiya V. Ruzhylo, Walery Zukow, and Anatoliy I. Gozhenko. "Neuroendocrine-immune complex as the mirror of the state of exchange of nitrogenous metabolites at rats." Journal of Education, Health and Sport 11, no. 8 (2021): 55–65. https://doi.org/10.12775/JEHS.2021.11.08.006.

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<strong>Popovych</strong> <strong>Igor L.</strong><strong>,</strong><strong> Kuchma</strong> <strong>Igor L., Ruzhylo Sofiya V., Zukow Walery, Gozhenko Anatoliy I.</strong> <strong>Neuroendocrine-immune complex as the mirror</strong> <strong>of the state of exchange</strong> <strong>of </strong><strong>nitrogenous</strong><strong> metabolites at rats</strong><strong>. </strong><strong>Jou</strong><strong>rnal of Education, Health and Sport. 2021;11(8):</strong><strong>55</strong><strong>-</strong><strong>65</strong><strong>. eISSN 2391-8306. DOI </strong><str

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Gozhenko, Olena A., Yuriy V. Zavidnyuk, Mykhaylo M. Korda, et al. "Features of neuro-endocrine and immune reactions to various water-salt loads in female rats." Journal of Education, Health and Sport 8, no. 9 (2018): 11–31. https://doi.org/10.5281/zenodo.1323491.

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<strong>Gozhenko Olena A, Zavidnyuk Yuriy V, Korda Mykhaylo M, Mysula Igor R, Klishch Ivan M, Zukow Walery, Popovych Igor L. </strong><strong>F</strong><strong>EATURES OF</strong><strong> NEURO-ENDOCRINE AND IMMUNE REACTIONS TO VARIOUS WATER-SALT LOADS IN FEMALE RATS</strong><strong>.</strong><strong> Journal </strong><strong>of Education, Health and Sport. 2018;8(9):11-31. </strong><strong>e</strong><strong>ISSN 2391-8306. DOI </strong><strong>http://dx.doi.org/10.5281/zenodo.1323491</strong> <strong>http://ojs.ukw.edu.pl/index.php/johs/article/view/5729</strong> <strong>https://pbn.nauka.gov

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Tserkovniuk, R., A. Gozhenko, T. Korolyshyn та ін. "Relationships between geomagnetic Ар-indeх and parameters of the acupuncture points as well as neuroendocrine-immune complex in patients with its dysfunction". Journal of Education, Health and Sport 11, № 12 (2021): 405–32. http://dx.doi.org/10.12775/jehs.2021.11.12.034.

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Background. Back in 1990, YuP Limansky hypothesized acupuncture points (AP) as polymodal receptors of the ecoceptive sensitivity system. In the process of hypothesis development in 2003 an existence of separate functional system of regulation of electromagnetic balance of organism has been substantiated and a working conception of light therapy has been formulated. In line with this hypothesis, we set out to analyze the relationships between the disturbances of the geomagnetic field (Ap-index) and the electrical conductivity of a number of AP, on the one hand, and the parameters of the neuroen

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Babelyuk, Valeriy, Ruslan Tserkovniuk, Galyna Dubkova, et al. "Relationships between the neuro-endocrine parameters and virtual chakras energy and asymmetry." Journal of Education, Health and Sport 12, no. 1 (2022): 235–49. http://dx.doi.org/10.12775/jehs.2022.12.01.020.

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Background. Earlier, we found a close correlation between EEG and gas-discharge image (GDI) parameters. The aim of this study is to analyze the relationship of EEG parameters with the energy and asymmetry of virtual chakras, reconstructed on the basis of GDI parameters. Material and Methods. We observed twice 31 women and 29 men aged 26-76 years with dysfunction of neuroendocrine-immune complex. In the morning in basal conditions at first registered GDI by the method of GDV by the device “GDV Chamber” (“Biotechprogress”, SPb, RF). Than we registered EEG. Results processed by method of canonica

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Popadynets’, Oleksandr, Volodymyra Bilas, Igor-Severyn Flyunt, et al. "Features of the condition of the neuroendocrine-immune complex in different constellations of entropies of morpho-functional immune subsystems in rats." Journal of Education, Health and Sport 10, no. 8 (2020): 214. http://dx.doi.org/10.12775/jehs.2020.10.08.025.

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ZAVIDNYUK, Y., O. MEL’NYK, and O. MYSAKOVETS’. "Factor analysis of the information field of the neuroendocrine-immune complex and metabolism in female rats." Experimental and Clinical Physiology and Biochemistry 2019, no. 3 (2019): 12–22. http://dx.doi.org/10.25040/ecpb2019.03.012.

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Wang, Lingling, Zhaoqun Liu, Zhi Zhou, and Linsheng Song. "The neuroendocrine-immune regulatory network characterized as simple structure but complex function in oyster Crassostrea gigas." Fish & Shellfish Immunology 53 (June 2016): 81. http://dx.doi.org/10.1016/j.fsi.2016.03.110.

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Popovych, Daria V., Nataliya S. Badiuk, Myroslava V. Hrytsak, Sofiya V. Ruzhylo, and Oksana I. Mel'nyk. "Sulfate-chloride sodium-magnesium mineral waters modulate neuroendocrine-immune complex and metabolism in healthy female rats." Journal of Education, Health and Sport 11, no. 12 (2021): 455–66. https://doi.org/10.5281/zenodo.6320770.

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<strong>Popovych Daria</strong> <strong>V.</strong><strong>, </strong><strong>Badiuk</strong> <strong>Nataliya</strong> <strong>S.</strong><strong>, </strong><strong>Hrytsak</strong> <strong>Myroslava</strong> <strong>V.</strong><strong>,</strong> <strong>Ruzhylo Sofiya</strong> <strong>V</strong><strong>., </strong><strong>Mel</strong><strong>’</strong><strong>nyk</strong> <strong>Oksana</strong> <strong>I</strong><strong>.,</strong> <strong>Żukow Xawery</strong><strong>.</strong> <strong>Sulfate-chloride sodium-magnesium mineral waters</strong><strong> modulate neuroendocrine-immune co

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Markovic, Ljiljana. "Interaction involving the thymus and the hypothalamus-pituitary axis, immunomodulation by hormones." Srpski arhiv za celokupno lekarstvo 132, no. 5-6 (2004): 187–93. http://dx.doi.org/10.2298/sarh0406187m.

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Perfectly projected and impeccably created, the endocrine system precisely regulates the most delicate immune processes. The immune and neuroendocrine systems are two essential physiological components of mammalian organisms important for protection from the infection and disease on one hand, and on the other, for regulation of metabolism and other physiological activities; namely, the evidence has been found indicating that there is active and dynamic collaboration of these systems in the execution of their designated functions [1, 2,4]. These interactions occur at many stages of embryonic an

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Tserkovniuk, R., A. Gozhenko, T. Korolyshyn та ін. "Relationships between geomagnetic Ар-indeх and EEG parameters in patients with dysfunction of the neuroendocrine-immune complex". Journal of Education, Health and Sport 11, № 8 (2021): 536–52. http://dx.doi.org/10.12775/jehs.2021.11.08.060.

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Background. Recently, on the example of two cohort of patients, we found that disturbances of the geomagnetic field cause a significant immediate modulating effect on the level of immune parameters in the blood. The data available in the literature give grounds for assumptions about the direct effect of disturbances of the geomagnetic field on immunocytes, and indirectly, through immunotropic neurotransmitters and hormones. Our hypothesis is as follows. Disturbances of the geomagnetic field are perceived by acupuncture points (APs). The information obtained is transmitted to neurons and endocr

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Dal Lin, Carlo, Francesco Tona, and Elena Osto. "Coronary Microvascular Function and Beyond: The Crosstalk between Hormones, Cytokines, and Neurotransmitters." International Journal of Endocrinology 2015 (2015): 1–17. http://dx.doi.org/10.1155/2015/312848.

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Beyond its hemodynamic function, the heart also acts as a neuroendocrine and immunoregulatory organ. A dynamic communication between the heart and other organs takes place constantly to maintain cardiovascular homeostasis. The current understanding highlights the importance of the endocrine, immune, and nervous factors to fine-tune the crosstalk of the cardiovascular system with the entire body. Once disrupted, this complex interorgan communication may promote the onset and the progression of cardiovascular diseases. Thus, expanding our knowledge on how these factors influence the cardiovascul

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Tashiro, Takahiro, Kosuke Imamura, Yusuke Tomita, et al. "Heterogeneous Tumor-Immune Microenvironments between Primary and Metastatic Tumors in a Patient with ALK Rearrangement-Positive Large Cell Neuroendocrine Carcinoma." International Journal of Molecular Sciences 21, no. 24 (2020): 9705. http://dx.doi.org/10.3390/ijms21249705.

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Evolution of tumor-immune microenviroments (TIMEs) occurs during tumor growth and dissemination. Understanding inter-site tumor-immune heterogeneity is essential to harness the immune system for cancer therapy. While the development of immunotherapy against lung cancer with driver mutations and neuroendocrine tumors is ongoing, little is known about the TIME of large cell neuroendocrine carcinoma (LCNEC) or anaplastic lymphoma kinase (ALK) rearrangement-positive lung cancer. We present a case study of a 32-year-old female patient with ALK-rearrangement-positive LCNEC, who had multiple distant

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Matwiejuk, Mateusz, Agnieszka Kulczyńska-Przybik, Hanna Myśliwiec, Adrian Chabowski, Barbara Mroczko, and Iwona Flisiak. "The Role of Selected Proteins in the Pathogenesis of Psoriasis." International Journal of Molecular Sciences 26, no. 13 (2025): 6475. https://doi.org/10.3390/ijms26136475.

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Psoriasis is a chronic, immune-mediated inflammatory skin disease with complex genetic, environmental, and immunological determinants. Beyond the skin, it affects multiple systems, including the joints and cardiovascular system. A hallmark of psoriasis is an overactivation of the innate and adaptive immune responses, leading to dysregulated cytokine signaling, altered keratinocyte function, and aberrant expression of structural and regulatory proteins. In recent years, growing attention has been given to the skin as a neuro–immuno–endocrine organ, with evidence showing the role of stress-relat

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Barylyak, Liliya, Volodymyr Tsymbryla, Walery Zukow, and Igor Popovych. "Variants of plasma lipoprotein profile in persons with maladaptation." Journal of Education, Health and Sport 5, no. 3 (2015): 381–94. http://dx.doi.org/10.12775/jehs.2015.05.03.032.

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Introduction and aim. Atherogenic lipoprotein profile of plasma is an important risk factor for coronary artery disease. It is characterized by high ratio of logarithm of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-Ch) called as “atherogenic index of plasma” (AIP). AIP reflect the actual composition of the lipoprotein spectrum and thus predict both the cardiovascular risk and effectiveness of therapy. This article initiates the project "Relationships between plasma lipoprotein profile and neuroendocrine-immune complex parameters and the influence on them of the factors of t

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Tsymbryla, Volodymyr, Liliya Barylyak, Xawery Żukow, and Igor Popovych. "Metabolic accompaniment of plasma lipoproteins profile in persons with maladaptation." Journal of Education, Health and Sport 42, no. 1 (2023): 174–88. http://dx.doi.org/10.12775/jehs.2023.42.01.016.

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Background. During the implementation of the project "The relationship between the lipoprotein profile of the blood plasma and the parameters of the neuroendocrine-immune complex, and the influence of the factors of the Truskavets’ spa on them", we first divided observed cohort into 5 homogeneous groups that differed from each other by 6 discriminant variables. The purpose of this study is to identify the metabolic accompaniment of plasma lipoprotein profile in the same persons. Material and research methods. The object of observation were 41 volunteers: 20 women aged 30-76 years and 21

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Sen, Triparna, Subhamoy Chakraborty, Andrew Elliott, et al. "Unveiling drivers of MHC repression and therapeutic strategies to counter immune evasion in small cell lung cancer." Journal of Clinical Oncology 43, no. 16_suppl (2025): 8091. https://doi.org/10.1200/jco.2025.43.16_suppl.8091.

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8091 Background: Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine malignancy with a median survival of 9–11 months. Despite the addition of immune checkpoint blockade (ICB) to frontline chemotherapy, improvements remain limited. SCLC evades anti-tumor immunity by suppressing major histocompatibility complex class I (MHC-I) and antigen presentation (AP). The variability of MHC repression across molecular subtypes of SCLC and high-grade neuroendocrine tumors is not fully understood. This study analyzed clinical SCLC and neuroendocrine tumor samples to identify molecular subtyp

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Nowik, Natalia, Anna Przyborowska, Waldemar Sienkiewicz, and Piotr Podlasz. "Protective Role of Galanin during Chemically Induced Inflammation in Zebrafish Larvae." Biology 10, no. 2 (2021): 99. http://dx.doi.org/10.3390/biology10020099.

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During a pathological condition, many different systems are involved in the response of an affected organism. Galanin is considered to be a neuropeptide that plays an important role in the central nervous system; however, it is involved in many other biological processes, including the immune response. During our studies, we showed that galanin became upregulated in zebrafish larvae when exposed to copper sulfate. Moreover, the presence of normal levels of galanin, administration of a galanin analog NAX 5055 or galanin overexpression led to lowered lateral line damage and enhanced expression o

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Tserkovniuk, R.G., A.I. Gozhenko, T.A. Korolyshyn та ін. "Relationships between geomagnetic Ар-indeх and EEG parameters in patients with dysfunction of the neuroendocrine-immune complex". Journal of Education, Health and Sport 11, № 8 (2021): 536–52. https://doi.org/10.12775/JEHS.2021.11.08.060.

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<strong>Tserkovniuk R.G., Gozhenko A.I., Korolyshyn T.A., Lomeyko S.M., Fil V.M., Anchev A.S., Zukow W., Yanchij R.I., Popovych I.L. </strong><strong>Relationships between geomagnetic Ар-indeх and EE</strong><strong>G</strong><strong> parameters in patients with dysfunction of the neuroendocrine-immune complex</strong><strong>. Journal of Education, Health and Sport. 2021;11(</strong><strong>8</strong><strong>):</strong><strong>536</strong><strong>-</strong><strong>552</strong><strong>. eISSN 2391-8306. DOI </strong><strong>http://dx.doi.org/10.12775/JEHS.2021.11.0</strong><strong>8</stro

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Trusov, P. V., N. V. Zaitseva, V. M. Chigvintsev, and D. V. Lanin. "Regulation of Organism's Antiviral Immune Response: Mathematical Model, Qualitative Analysis, Results." Mathematical Biology and Bioinformatics 13, no. 2 (2018): 402–25. http://dx.doi.org/10.17537/2018.13.402.

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To know the processes occurring in the neuroendocrine and immune system, the complex and branching regulation mechanisms should be taken into account. Most of the studies in this area are dedicated to the biological and mathematical description of individual parts of the regulatory mechanisms, and it greatly facilitates the understanding of the phenomena being studied. But there is a lack of comprehensive description of the processes and internal communications. In the present article, a mathematical model for describing the antiviral immune response is considered taking into account the inter

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Xu, Jian, Qi Feng, Yong Chen, Xiu-lan Liu, and Ou Jiang. "Complete remission of combined pulmonary large cell neuroendocrine carcinoma: a case report." Journal of International Medical Research 49, no. 11 (2021): 030006052110553. http://dx.doi.org/10.1177/03000605211055387.

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Pulmonary large cell neuroendocrine carcinoma (LCNEC), which accounts for approximately 1% of all lung cancers, is a rare and highly aggressive malignancy with a poor prognosis. Therefore, it is important to devise an effective treatment strategy. In the treatment of locally advanced complex LCNEC, it is unique to first administer radiotherapy combined with albumin-bound paclitaxel plus carboplatin, followed by durvalumab for immune maintenance treatment after concurrent radiotherapy and chemotherapy to achieve complete remission. We report a 54-year-old man who smoked and who felt chest tight

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Sirufo, Maria Maddalena, Lia Ginaldi, and Massimo De Martinis. "Peripheral Vascular Abnormalities in Anorexia Nervosa: A Psycho-Neuro-Immune-Metabolic Connection." International Journal of Molecular Sciences 22, no. 9 (2021): 5043. http://dx.doi.org/10.3390/ijms22095043.

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Immune, neuroendocrine, and autonomic nervous system dysregulation in anorexia nervosa lead to cardiovascular complications that can potentially result in increased morbidity and mortality. It is suggested that a complex non-invasive assessment of cardiovascular autonomic regulation—cardiac vagal control, sympathetic vascular activity, and cardiovascular reflex control—could represent a promising tool for early diagnosis, personalized therapy, and monitoring of therapeutic interventions in anorexia nervosa particularly at a vulnerable adolescent age. In this view, we recommend to consider in t

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