Academic literature on the topic 'Neuronal ageing'

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Journal articles on the topic "Neuronal ageing"

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Mattson, Mark P., and Tim Magnus. "Ageing and neuronal vulnerability." Nature Reviews Neuroscience 7, no. 4 (2006): 278–94. http://dx.doi.org/10.1038/nrn1886.

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Verkhratsky, Alexej, and Emil C. Toescu. "Calcium and neuronal ageing." Trends in Neurosciences 21, no. 1 (1998): 2–7. http://dx.doi.org/10.1016/s0166-2236(97)01156-9.

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Toescu, Emil. "The healthy ageing of the Ca2+ hypothesis." Ageing & Longevity, no. 1.2025 (February 11, 2025): 37–45. https://doi.org/10.47855/jal9020-2025-1-5.

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Normal brain ageing is associated with a varying degree of cognitive impairment. One of the early hypotheses proposed to explain such changes was the “Ca2+ hypothesis of ageing”. This review revisits this hypothesis and uses the Ca2+ dependency of neuronal excitability as an integrator to discuss the age-dependent changes in the activity of the various systems and mechanisms that control neuronal Ca2+ homeostasis. Amongst these systems, special attention is given to the mitochondrial involvement in the regulation of neuronal Ca2+, and to the fact that changes in mitochondrial functions induced
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Tsvetanov, Kamen A., Richard N. A. Henson, and James B. Rowe. "Separating vascular and neuronal effects of age on fMRI BOLD signals." Philosophical Transactions of the Royal Society B: Biological Sciences 376, no. 1815 (2020): 20190631. http://dx.doi.org/10.1098/rstb.2019.0631.

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Accurate identification of brain function is necessary to understand the neurobiology of cognitive ageing, and thereby promote well-being across the lifespan. A common tool used to investigate neurocognitive ageing is functional magnetic resonance imaging (fMRI). However, although fMRI data are often interpreted in terms of neuronal activity, the blood oxygenation level-dependent (BOLD) signal measured by fMRI includes contributions of both vascular and neuronal factors, which change differentially with age. While some studies investigate vascular ageing factors, the results of these studies a
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Toescu, Emil C., and Alex Verkhratsky. "Neuronal ageing in long-term cultures." NeuroReport 11, no. 17 (2000): 3725–29. http://dx.doi.org/10.1097/00001756-200011270-00027.

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Okenve-Ramos, Pilar, Rory Gosling, Monika Chojnowska-Monga, et al. "Neuronal ageing is promoted by the decay of the microtubule cytoskeleton." PLOS Biology 22, no. 3 (2024): e3002504. http://dx.doi.org/10.1371/journal.pbio.3002504.

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Natural ageing is accompanied by a decline in motor, sensory, and cognitive functions, all impacting quality of life. Ageing is also the predominant risk factor for many neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease. We need to therefore gain a better understanding of the cellular and physiological processes underlying age-related neuronal decay. However, gaining this understanding is a slow process due to the large amount of time required to age mammalian or vertebrate animal models. Here, we introduce a new cellular model within the Drosophila brain, in wh
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Sharma, S. P., I. K. Patro, Nisha Patro, and T. J. James. "‘Dark’ type Purkinje cells and neuronal ageing." Proceedings: Animal Sciences 97, no. 5 (1988): 449–53. http://dx.doi.org/10.1007/bf03179952.

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Delgado‐González, José Carlos, Carlos Rosa‐Prieto, Diana Lucía Tarruella‐Hernández, et al. "Neuronal volume of the hippocampal regions in ageing." Journal of Anatomy 237, no. 2 (2020): 301–10. http://dx.doi.org/10.1111/joa.13189.

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TOESCU, EMIL C., and ALEXEJ VERKHRATSKY. "Parameters of calcium homeostasis in normal neuronal ageing." Journal of Anatomy 197, no. 4 (2000): 563–69. http://dx.doi.org/10.1046/j.1469-7580.2000.19740563.x.

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Surmeier, D. James. "Calcium, ageing, and neuronal vulnerability in Parkinson's disease." Lancet Neurology 6, no. 10 (2007): 933–38. http://dx.doi.org/10.1016/s1474-4422(07)70246-6.

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Dissertations / Theses on the topic "Neuronal ageing"

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Andrews, Timothy John. "The role of targets and growth factors in neuronal ageing." Thesis, University College London (University of London), 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307442.

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McKillop, Laura. "Sleep slow wave oscillation : effect of ageing and preceding sleep-wake history." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:a3c762ab-cbc0-4095-86db-99e04dc7e84f.

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Sleep is well-established to become more superficial and fragmented as we age, with deficits in cognitive processing also commonly observed. While effects have been identified in both humans and mice (used in this thesis), there are important species differences in these findings and importantly, very little is known about the neural dynamics underlying these changes. By integrating several state-of-the-art approaches from putative single unit electrophysiological recordings to behavioural and pharmacological assessments, this thesis aimed to provide novel insights into the neural mechanisms i
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Chew, Yee Lian. "Protein with Tau-like repeats (PTL-1) modulates the oxidative stress response, neuronal ageing and lifespan." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/12497.

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Protein with Tau-like repeats (PTL-1) is the sole Tau /MAP2/MAP4 homolog in Caenorhabditis elegans. Dysregulation of Tau is a pathological hallmark of neurodegenerative diseases such as Alzheimer’s disease. Therefore, reducing Tau levels has been suggested as a therapeutic strategy. We used PTL-1 to model the biological functions of a Tau-like protein without the complication of functional redundancy. Firstly, our data indicate that PTL-1 in the nervous system mediates the oxidative stress response in a pathway that may involve the C. elegans homolog of the Nrf2 transcription factor, SKN-1. I
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Ladd, Aliny Antunes Barbosa Lobo. "Mecanismos de proliferação neuronal pós-natal no gânglio cervical cranial de preás (Galea spixii spixii) Wagler, 1831. Neurogênese x diferenciação neuronal tardia." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-17122009-162828/.

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Neste estudo, foram abordados os aspectos quantitativos do gânglio cervical cranial (GCC) esquerdo de preás (Galea spixii spixii) machos, oriundos do criatório da Universidade Federal Rural do Semi-Árido Nordestino de Mossoró-RN. Os seguintes parâmetros foram estimados: volume do GCC, número total e tamanho dos neurônios (uni e binucleados) durante dois períodos do desenvolvimento pós-natal (maturação e envelhecimento). Para tanto, utilizamos quatro grupos etários distintos de animais: neonatos, jovens, adultos e senis. Após a eutanásia dos animais, os GCCs foram fixados (perfusão sistêmica) c
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Abele, Julia Verfasser], and Daniela C. [Gutachter] [Dieterich. "Ageing in a dish : strategies ro rejuvenate neuronal cell cultures and balance protein homoeostasis / Julia Abele ; Gutachter: Daniela C. Dieterich." Magdeburg : Universitätsbibliothek Otto-von-Guericke-Universität, 2019. http://d-nb.info/1219965723/34.

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Steinbach, Simone [Verfasser], Katrin [Gutachter] Marcus, and Dirk [Gutachter] Wolters. "A proteomic investigation of the ageing \(\textit substantia nigra}\) and the selective neuronal vulnerability of its neurons / Simone Steinbach ; Gutachter: Katrin Marcus, Dirk Wolters ; Fakultät für Chemie und Biochemie." Bochum : Ruhr-Universität Bochum, 2018. http://d-nb.info/1167505034/34.

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Marutle, Amelia. "Neuronal nicotinic receptor subtypes in normal ageing, Alzheimer's disease and schizophrenia : influences of neuropathological mechanisms as studied in human autopsy brain and transgenic mice /." Stockholm : [Karolinska institutets bibl.], 2002. http://diss.kib.ki.se/2002/91-7349-133-0.

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Morgan, Lindsay Dawn. "A characterisation and functional analysis of the role of the 14-3-3-like proteins in neuronal ageing in the pond snail, Lymnaea stagnalis." Thesis, University of Brighton, 2012. https://research.brighton.ac.uk/en/studentTheses/e356047e-62f2-4905-bcef-c995044ceb44.

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14-3-3 proteins are a ubiquitous family known for their ability to regulate myriad cellular processes including lifespan, neuronal signalling and transduction, protein trafficking and transmitter production and release. Previous work has shown that 14-3-3 proteins are linked to a variety of pathological neurodegenerative diseases although their role in healthy brain ageing is currently unclear. This study utilised the pond snail, Lymnaea stagnalis to examine the contribution made by 14-3-3 to the decrease in feeding rate that is seen in this model system with age. Interrogation of a Lymnaea CN
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Drbal, Abed Alnaser A. A. "Studies on Bioactive Lipid Mediators Involved in Brain Function and Neurodegenerative Disorders. The effect of ¿-3PUFA supplementation and lithium treatment on rat brain sphingomyelin species and endocannabinoids formation; changes in oxysterol profiles in blood of ALS patients and animal models of ALS." Thesis, University of Bradford, 2013. http://hdl.handle.net/10454/6285.

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Lipids are important for structural and physiological functions of neuronal cell membranes. They exhibit a range of biological effects many are bioactive lipid mediators derived from polyunsaturated fatty acids such as sphingolipids, fatty acid ethanolamides (FA-EA) and endocannabinoids (EC). These lipid mediators and oxysterols elicit potent bioactive functions in many physiological and pathological processes of the brain and neuronal tissues. They have been investigated for biomarker discovery of ageing, neuroinflammation and neurodegenerative disorders. The n-3 fatty acids EPA and DPA are t
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Alsbury, Samantha Jane. "Neuroprotection and ageing in sensory neurons." Thesis, University College London (University of London), 2004. http://discovery.ucl.ac.uk/1446474/.

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Cardiotrophin-l (CT-1) and Urocortin (UCN) are peptides which have previously been shown to have protective effects in cardiac myocytes and which induce heat shock protein expression. CT-1 is a member of the interleukin-6 family of cytokines. UCN is a peptide expressed in the brain that binds to the corticotrophin releasing hormone receptors. In this investigation the ability of CT-1 and UCN to protect cells against a lethal stress was tested in neonatal and adult sensory neurons. CT-1 has a protective effect against hypoxic ischaemia in neonatal sensory neurons; in contrast although CT-1 indu
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Books on the topic "Neuronal ageing"

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Bowker, Lesley K., James D. Price, Ku Shah, and Sarah C. Smith. Neurology. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198738381.003.0007.

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This chapter provides information on the ageing brain and nervous system, tremor, neuropathic pain/neuralgia, presentation of Parkinson’s disease, management of Parkinson’s disease, diseases masquerading as Parkinson’s disease, epilepsy and its drug treatment, neuroleptic malignant syndrome, motor neuron disease, peripheral neuropathies, subdural haematoma, sleep and insomnia, and other sleep disorders.
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Guo, Xiang-Gui, Jian-Liang Wang, Fang Liao, and Rodney Swee Huat Teo. Multi-Agent Systems. Taylor & Francis Group, 2019.

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Taillefer, Raymond, and Frans J. Th Wackers. Kinetics of Conventional and New Cardiac Radiotracers. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199392094.003.0004.

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The kinetics of radiotracers, that is the mode of uptake, retention and release from the myocardium, are relevant for designing and implementing optimized nuclear cardiac imaging protocols. This chapter addresses the kinetics of commonly used radiotracers for imaging myocardial perfusion, sympathetic neuronal function and cardiac metabolism, both with SPECT and PET cardiac imaging. The optimal timing of imaging after injection either at stress or at rest is determined by rate of uptake in the heart and adjacent organs, as well as the residence time of radiotracers within the myocytes. The effi
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Guo, Xiang-Gui, Jian-Liang Wang, Fang Liao, and Rodney Swee Huat Teo. Multi-Agent Systems: Platoon Control and Non-Fragile Quantized Consensus. Taylor & Francis Group, 2019.

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Guo, Xiang-Gui, Jian-Liang Wang, Fang Liao, and Rodney Swee Huat Teo. Multi-Agent Systems: Platoon Control and Non-Fragile Quantized Consensus. Taylor & Francis Group, 2019.

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Teo, Rodney, Xiang-Gui Guo, Jian-Liang Wang, and Fang Liao. Multi-Agent Systems: Platoon Control and Non-Fragile Quantized Consensus. Taylor & Francis Group, 2022.

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Multi-Agent Systems: Platoon Control and Non-Fragile Quantized Consensus. Taylor & Francis Group, 2019.

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Nagy, Istvan. The capsaicin receptor. Edited by Paul Farquhar-Smith, Pierre Beaulieu, and Sian Jagger. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198834359.003.0027.

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The landmark paper discussed in this chapter is ‘The capsaicin receptor: A heat activated ion channel in the pain pathway’, published by Caterina et al. in 1997. The identification of the molecular basis for the sensitivity of a major proportion of nociceptive primary sensory neurons for capsaicin, the pungent agent in chilli pepper, was undoubtedly one of the most significant pain-related discoveries in the twentieth century, for at least three reasons. First, the mechanism for capsaicin-induced responses could unequivocally be explained. Second, the discovery heralded the starting point for
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Columb, Malachy O. Local anaesthetic agents. Edited by Michel M. R. F. Struys. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199642045.003.0017.

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Local anaesthetic agents cause a pharmacologically induced reversible neuropathy characterized by axonal conduction blockade. They act by blocking the sodium ionophore and exhibit membrane stabilizing activity by inhibiting initiation and propagation of action potentials. They are weak bases consisting of three components: a lipophilic aromatic ring, a link, and a hydrophilic amine. The chemical link classifies them as esters or amides. Local anaesthetics diffuse through the axolemma as unionized free-base and block the ionophore in the quaternary ammonium ionized form. The speed of onset of b
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Shaw, Pamela, and David Hilton-Jones. The lower cranial nerves and dysphagia. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198569381.003.0429.

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Disorders affecting the lower cranial nerves – V (trigeminal), VII (facial), IX (glossopharyngeal), X (vagus), XI (accessory) and XII (hypoglossal) – are discussed in the first part of this chapter. The clinical neuroanatomy of each nerve is described in detail, as are disorders – often in the form of lesions – for each nerve.Trigeminal nerve function may be affected by supranuclear, nuclear, or peripheral lesions. Because of the wide anatomical distribution of the components of the trigeminal nerve, complete interruption of both the motor and sensory parts is rarely observed in practice. Howe
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Book chapters on the topic "Neuronal ageing"

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Damiani, Elisabetta, and Rosita Gabbianelli. "Nutrigenomics as a Strategy for Neuronal Health." In Healthy Ageing and Longevity. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-24958-8_9.

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Dunnett, S. B. "Short-Term Memory in Rodent Models of Ageing: Effects of Cortical Cholinergic Grafts." In Neuronal Grafting and Alzheimer’s Disease. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-48369-1_9.

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Heiser, M., B. Hutter-Paier, L. Jerkovic, et al. "Vitamin E binding protein A famin Protects Neuronal Cells in vitro." In Ageing and Dementia Current and Future Concepts. Springer Vienna, 2002. http://dx.doi.org/10.1007/978-3-7091-6139-5_32.

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Arendt, T. "Dysregulation of neuronal differentiation and cell cycle control in Alzheimer’s disease." In Ageing and Dementia Current and Future Concepts. Springer Vienna, 2002. http://dx.doi.org/10.1007/978-3-7091-6139-5_8.

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Humpel, C., and C. Weis. "Nerve growth factor and cholinergic CNS neurons studied in organotypic brain slices." In Ageing and Dementia Current and Future Concepts. Springer Vienna, 2002. http://dx.doi.org/10.1007/978-3-7091-6139-5_23.

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Prabhakaran, Adarsh, and Somdatta Sinha. "Infection Spread in Populations: An Agent-Based Model." In Trends in Biomathematics: Modeling Epidemiological, Neuronal, and Social Dynamics. Springer Nature Switzerland, 2023. http://dx.doi.org/10.1007/978-3-031-33050-6_2.

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Davison, A. N. "Functional Morphology of Neurons During Normal and Pathological Ageing." In Modification of Cell to Cell Signals During Normal and Pathological Aging. Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-72729-0_1.

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Gluckman, P. D., C. E. Williams, J. Guan, et al. "The Potential of IGF-I as a Neuronal Rescue Agent." In IGFs in the Nervous System. Springer Milan, 1998. http://dx.doi.org/10.1007/978-88-470-2246-1_8.

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Santer, R. M., and U. Kabeer. "Morphometric Analysis of Alkaline Phosphatase Stained Capillaries in Rat Sympathetic Ganglia: Changes During Development and Ageing." In Histochemistry and Cell Biology of Autonomic Neurons and Paraganglia. Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-72749-8_49.

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Payá, Antonio Soriano, Juan Manuel García Chamizo, and Francisco Maciá Pérez. "An Agent Based Framework for Modelling Neuronal Regulators of the Biological Systems." In MICAI 2004: Advances in Artificial Intelligence. Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-540-24694-7_38.

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Conference papers on the topic "Neuronal ageing"

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Wang, Bing, Tuan D. Pham, Tuan D. Pham, et al. "Estimating Neuronal Ageing with Hidden Markov Models." In 2011 INTERNATIONAL SYMPOSIUM ON COMPUTATIONAL MODELS FOR LIFE SCIENCES (CMLS-11). AIP, 2011. http://dx.doi.org/10.1063/1.3596633.

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Pryczek, Michal, and Piotr S. Szczepaniak. "Supervised Textual Document Classification Using Neuronal Group Learning." In 2008 IEEE/WIC/ACM International Conference on Web Intelligence and Intelligent Agent Technology. IEEE, 2008. http://dx.doi.org/10.1109/wiiat.2008.94.

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Kudoh, Suguru N. "A semi-living broken Dialogue Agent Depending on the Internal State of a Living Neuronal Network." In HAI '23: International Conference on Human-Agent Interaction. ACM, 2023. http://dx.doi.org/10.1145/3623809.3623947.

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Umebayashi, Ryu, and Suguru N. Kudoh. "A Living Dialogue Agent Depending on the Internal State of a Cultured Neuronal Network." In 2018 Joint 10th International Conference on Soft Computing and Intelligent Systems (SCIS) and 19th International Symposium on Advanced Intelligent Systems (ISIS). IEEE, 2018. http://dx.doi.org/10.1109/scis-isis.2018.00152.

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Chen, Yinda, Wei Huang, Shenglong Zhou, Qi Chen, and Zhiwei Xiong. "Self-Supervised Neuron Segmentation with Multi-Agent Reinforcement Learning." In Thirty-Second International Joint Conference on Artificial Intelligence {IJCAI-23}. International Joint Conferences on Artificial Intelligence Organization, 2023. http://dx.doi.org/10.24963/ijcai.2023/68.

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The performance of existing supervised neuron segmentation methods is highly dependent on the number of accurate annotations, especially when applied to large scale electron microscopy (EM) data. By extracting semantic information from unlabeled data, self-supervised methods can improve the performance of downstream tasks, among which the mask image model (MIM) has been widely used due to its simplicity and effectiveness in recovering original information from masked images. However, due to the high degree of structural locality in EM images, as well as the existence of considerable noise, man
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Huyck, Christian. "CABot1: A videogame agent implemented in fLIF neurons." In 2008 7th IEEE International Conference on Cybernetic Intelligent Systems (CIS). IEEE, 2008. http://dx.doi.org/10.1109/ukricis.2008.4798923.

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Sekowski, J. W., M. A. Orehek, J. Bucher, et al. "LOW-LEVEL INHALATION EXPOSURE TO CHEMICAL NERVE AGENT VAPOR INDUCES EXPRESSION OF NEURONAL APOPTOSIS AND REGENERATION GENES." In Proceedings of the 24th US Army Science Conference. WORLD SCIENTIFIC, 2006. http://dx.doi.org/10.1142/9789812772572_0055.

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Oliveira, Victória Nunes, Mellyssa Cota Elias, Heloiza Castilhoni Belique, et al. "Case of aluminium poisoning, with differential diagnosis for amyotrophic lateral sclerosis (als)." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.246.

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Introduction: Essential metals in high quantities can accumulate and reach toxicity. In the CNS, they lead to neurodegeneration, causing movement and cognitive disorders. Case Report: White man, 59 years, sanitation agent, uses PPE irregularly. For 1 year presented progressive speech disorder, paresis, emaciation, dysphonia, tongue atrophy, limbs fasciculations and abnormal reflexes; normal tonus/ sensibility. Bulbar/limb electroneuromyography and serum dosage of metals in contact were requested, revealing muscles denervation, axonal diffuse polyneuropathy with postganglionic injury and elevat
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Tosatti, Jéssica, Adriana Fontes, Paulo Caramelli, and Karina Gomes. "EFFECTS OF RESVERATROL SUPPLEMENTATION ON THE COGNITIVE FUNCTION OF PATIENTS WITH ALZHEIMER’S DISEASE: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS." In XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda026.

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Background: Alzheimer’s disease (AD) is characterized by a deposition of β-amyloid peptide and the neurofibrillary tangles of tau protein. Resveratrol is a neuroprotective agent, acting in the prevention of redox impairment, and could reduce neuronal damage in patients with AD. Objectives: Systematic review and meta-analysis about the effects of resveratrol supplementation on cognitive and functional performance in patients with AD. Methods: Databases were searched for primary studies that reported cognitive and functional performance based on ADAS-cog, ADCS-ADL or MMSE instruments in AD patie
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Sundararaghavan, Harini G., and David I. Shreiber. "Directing Neurite Growth in 3D Collagen Scaffolds With Gradients of Mechanical Properties." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176659.

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Biomaterial scaffolds for nerve and spinal cord regeneration must not only promote neurite re-growth but also direct it. Several cell types, including neurons, respond to the mechanical properties of the substrate on which they are grown. We believe that gradients of mechanical properties can be used to direct neurons. To spatially control the mechanical properties, gradients of genipin — a naturally occurring, cell-tolerated crosslinking agent — are created in 3D through a compliant collagen gel using microfluidics. Gradients of mechanical properties are evaluated by measuring genipin-induced
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