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Dissertations / Theses on the topic 'Neuronal network activity'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Balakumar, Nikhil. "A Computational Model of Neuronal Cluster Activity." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1329936494.

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2

Gómez, Orlandi Javier. "Noise, coherent activity and network structure in neuronal cultures." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/346925.

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In this thesis we apply a multidisciplinary approach, based on statistical physics and complex systems, to the study of neuronal dynamics. We focus on understanding, using theoretical and computational tools, how collective neuronal activity emerges in a controlled system, a neuronal culture. We show how the interplay between noise and network structure defines the emergent collective behavior of the system. We build, using theory and simulation, a framework that takes carefully describes spontaneous activity in neuronal cultures by taking into account the underlying network structure of n

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3

Bhavaraju, Srilaya. "Using machine learning for analysis of neuronal network activity." Thesis, Massachusetts Institute of Technology, 2020. https://hdl.handle.net/1721.1/129131.

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Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, September, 2020<br>Cataloged from student-submitted PDF of thesis.<br>Includes bibliographical references (pages 75-77).<br>Analyzing neuronal activity in developing neuronal networks can improve our understanding of neuronal dysfunctions underlying conditions such as Rett syndrome. Two-photon calcium imaging is used to capture neuronal network activity over time. This method produces large sets of images that are typically manually analyzed by skilled neuroscientists. Because thi

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4

Samson, Andrew James. "Rapid neuronal responses during spreading neurotoxic and neuroprotective network activity." Thesis, University of Dundee, 2016. https://discovery.dundee.ac.uk/en/studentTheses/8c797952-eda1-4c03-a38a-15c2679e984f.

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Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system, playing critical roles in basal synaptic transmission and the molecular correlates of learning and memory, long-term potentiation and long-term depression. However, glutamate is also neurotoxic during prolonged exposure and the dysfunction of the glutamatergic system has been implicated in most neurological disorders, including stroke and epilepsy, and in certain neurodegenerative diseases, including Alzheimer’s disease. In these conditions, an increased concentration of extracellular glutamate causes a

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5

Prokic, Emma. "Modulation of neuronal network activity in the primary motor cortex." Thesis, Aston University, 2012. http://publications.aston.ac.uk/16496/.

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In the present study I investigated the mechanisms of modulation of neuronal network activity in rat primary motor cortex using pharmacological manipulations employing the in vitro brain slice technique. Preparation of the brain slice in sucrose-based aCSF produced slices with low viability. Introducing the neuroprotectants N-acetyl-cysteine, taurine and aminoguanidine to the preparatory method saw viability of slices increase significantly. Co-application of low dose kainic acid and carbachol consistently generated beta oscillatory activity in M1. Analyses indicated that network activity in M

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6

Yamawaki, Naoki. "Beta frequency neuronal network activity in the primary motor cortex." Thesis, Aston University, 2009. http://publications.aston.ac.uk/15408/.

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In this study I investigated the mechanisms of neuronal network oscillatory activity in rat M1 using pharmacological manipulations and electrical stimulation protocols, employing the in vitro brain slice technique in rat and magnetoencephalography (MEG) in man. Co-application of kainic acid and carbachol generated in vitro beta oscillatory activity in all layers in M1. Analyses indicated that oscillations originated from deep layers and indicated significant involvement of GABAA receptors and gap junctions. A modulatory role of GABAB, NMDA, and dopamine receptors was also evident. Intracellula

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7

Calderini, Matias. "Linear Discriminant Analysis and Noise Correlations in Neuronal Activity." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39962.

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The effects of noise correlations on neuronal stimulus discrimination have been the subject of sustained debate. Both experimental and computational work suggest beneficial and detrimental contributions of noise correlations. The aim of this study is to develop an analytically tractable model of stimulus discrimination that reveals the conditions leading to improved or impaired performance from model parameters and levels of noise correlation. We begin with a mean firing rate integrator model as an approximation of underlying spiking activity in neuronal circuits. We consider two independent

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8

Zhou, Pengcheng. "Computational Tools for Identification and Analysis of Neuronal Population Activity." Research Showcase @ CMU, 2016. http://repository.cmu.edu/dissertations/1015.

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Recently-developed technologies for monitoring activity in populations of neurons make it possible for the first time, in principle, to ask many basic questions in neuroscience. However, computational tools for analyzing newly available data need to be developed. The goal of this thesis is to contribute to this effort by focusing on two specific problems. First, we used a point-process regression framework to provide a methodology for statistical assessment of the link between neural spike synchrony and network-wide oscillations. In simulations, we showed that our method can recover ground-tru

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9

Lamanauskas, Nerijus. "Approaches to regulate neuronal network activity of hypoglossal motoneurons: nAChR agonists and riluzole." Doctoral thesis, SISSA, 2007. http://hdl.handle.net/20.500.11767/4675.

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Mammalian brainstem nuclei control vital functions of the body via the III-XII cranial nerves. The nucleus hypoglossus (XII nucleus) i1mervates the tongue musculature and, therefore, regulates several motor behaviors, including mastication, swallowing, sucking, and speech and is involved in respiration. These motor commands are generated by hypoglossal motoneuron (HM) network activity, which employs mainly glutamatergic nemotransmission. Neuronal network outputs are modulated by various factors, such as nicotinic acetylcholine receptors (nAChRs), persistent inward currents (PICs) and amb

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10

Marissal, Thomas. "Une approche développementale de l' hétérogénéité fonctionnelle des neurones pyramidaux de CA3." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM4001/document.

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Les neurones pyramidaux de la région CA3 de l'hippocampe présentent une diversité morphologique, physiologique, biochimique, mais aussi fonctionnelle. Une partie des caractéristiques des neurones étant acquise pendant le développement, nous avons formulé l'hypothèse que la diversité morpho-fonctionnelle des neurones pyramidaux serait déterminée aux stades embryonnaires. Pour tester cette hypothèse, nous avons utilisé des souris transgéniques pour lesquelles l'expression d'un marqueur fluorescent (GFP) est conditionnée par la date de neurogenèse des neurones glutamatergiques. Nous avons enregis

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11

Khouri, Raoul-Emil Roger. "Two-photon calcium imaging sequence Analysis Pipeline : a method for analyzing neuronal network activity." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/119748.

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Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2018.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references (page 73).<br>Investigating the development of neuronal networks can help us to identify new therapies and treatments for conditions that affect the brain, such as autism and Alzheimer's disease. Two-photon calcium imaging has been

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12

Soofi, Wafa Ahmed. "Regulation of rhythmic activity in the stomatogastric ganglion of decapod crustaceans." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/53440.

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Neuronal networks produce reliable functional output throughout the lifespan of an animal despite ceaseless molecular turnover and a constantly changing environment. The cellular and molecular mechanisms underlying the ability of these networks to maintain functional stability remain poorly understood. Central pattern generating circuits produce a stable, predictable rhythm, making them ideal candidates for studying mechanisms of activity maintenance. By identifying and characterizing the regulators of activity in small neuronal circuits, we not only obtain a clearer understanding of how ne

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13

Katona, Linda. "The role of cell-type selective synaptic connections in rhythmic neuronal network activity in the hippocampus." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:cebe42e9-4040-486b-8ff4-fa1bf642bea0.

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14

Heckenast, Julia. "Behaviour-dependent neuronal network activity in a novel CYFIP1 haplo-insufficient rat model of psychiatric risk." Thesis, Cardiff University, 2018. http://orca.cf.ac.uk/113333/.

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Advances in psychiatric genetics have begun to reveal the complex biological underpinnings of psychiatric disorders. Rare but penetrant copy number variants offer particularly direct mechanistic clues. The deletion at 15q11.2(BP1-BP2) has a 13% penetrance for developmental delay, congenital malformation, autism or schizophrenia. Reduced dosage of CYFIP1, one of four genes within this deletion, has emerged as a likely contributor to cognitive dysfunction seen in 15q11.2(BP1- BP2) deletion patients. However, the route from CYFIP1 haploinsufficiency to impaired behaviour has not been fully mapped

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15

Koussa, Mounir Ahmad. "Development of a Glial Network in the Olfactory Nerve: Role of a Calcium and Neuronal Activity." Thesis, The University of Arizona, 2011. http://hdl.handle.net/10150/144555.

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Kommajosyula, srinivasa prasad. "NEUROACTIVE AGENTS-MEDIATED CHANGES IN NEURONAL NETWORK ACTIVITY CONTROLS SUSCEPTIBILITY TO SUDDEN UNEXPECTED DEATH IN EPILEPSY (SUDEP)." OpenSIUC, 2017. https://opensiuc.lib.siu.edu/dissertations/1368.

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The incidence of sudden death is higher in epileptic people compared to the general population and sudden unexpected death in epilepsy (SUDEP) is second only to stroke in the years of potential life loss among the major neurological disorders. In the majority of observed human SUDEP cases, respiratory dysfunction post-seizure is shown to be the primary initiating event leading to cardiac asystole and death. During seizures, several neuroactive agents are shown to be released, including serotonin and adenosine. Previous research has shown the effects of these neuroactive agents on seizure and r

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17

Kalyanapu, Swetha Sri. "A model of delta frequency neuronal network activity and theta-gamma interactions in rat sensorimotor cortex in vitro." Thesis, Aston University, 2017. http://publications.aston.ac.uk/33429/.

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In recent decades, advances in electrophysiological techniques have enabled understanding of neuronal network activity, with in vitro brain slices providing insights into the mechanisms underlying oscillations at various frequency ranges. Understanding the electrical and neuro-pharmacological properties of brain networks using selective receptor modulators in native tissue allows to compare such properties with those in disease models (e.g. epilepsy and Parkinson’s). In vivo and in vitro studies have implicated M1 in execution of voluntary movements and, from both local network in vitro and wh

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18

Tomov, Petar Georgiev. "Interplay of dynamics and network topology in systems of excitable elements." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät, 2016. http://dx.doi.org/10.18452/17464.

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Wir untersuchen globale dynamische Phänomene, die sich von dem Zusammenspiel zwischen Netzwerktopologie und Dynamik der einzelnen Elementen ergeben. Im ersten Teil untersuchen wir relativ kleine strukturierte Netzwerke mit überschaubarer Komplexität. Als geeigneter theoretischer Rahmen für erregbare Systeme verwenden wir das Kuramoto und Shinomoto Modell der sinusförmig-gekoppelten "aktiven Rotatoren" und studieren das Kollektivverhalten des Systems in Bezug auf Synchronisation. Wir besprechen die Einschränkungen, die durch die Netzwerktopologie auf dem Fluss im Phasenraum des Systems geste

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19

Roschier, Ulla M. A. "Studies on neuronal network activity of olfactory bulb, spinal cord and frontal cortex grown on microelectrode arrays in vitro : the role of gap junctions in network integration." Thesis, University of Nottingham, 2006. http://eprints.nottingham.ac.uk/28291/.

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This project focused on understanding the mechanisms involved in CNS integration. The anatomy and physiology of mammalian olfactory system was investigated in order to develop an organotypic in vitro sensory system to increase our understanding of sensory processing at a neural network level. The olfactory network cultures grown on multielectrode arrays (MEAs) were found to only rarely exhibit electrical activity and it was decided this was an unsuitable preparation for the purposes of this study. The spinal cord was chosen as a secondary sensory system, initially in co-culture with dorsal roo

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20

Merseburg, Andrea [Verfasser], and Arp [Akademischer Betreuer] Schnittger. "HCN/h-channel deficiency in forebrain neurons impairs early postnatal development and alters neuronal network activity in mice (Mus musculus, Linnaeus 1758) / Andrea Merseburg. Betreuer: Arp Schnittger." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2016. http://d-nb.info/1110015909/34.

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21

Moutaux, Eve. "Régulation du transport axonal par l'activité neuronale : Implication pour le développement des réseaux neuronaux Neuronal activity recruits an axon-resident pool of secretory vesicles to regulate axon branching Reconstituting Corticostriatal Network on-a-Chip Reveals the Contribution of the Presynaptic Compartment to Huntington’s Disease Neuronal network maturation differently affects secretory vesicles and mitochondria transport in axons ALG-2 interacting protein-X (Alix) is required for activity-dependent bulk endocytosis at brain synapses An integrated microfluidic/microelectrode array for the study of activity-dependent intracellular dynamics in neuronal networks." Thesis, Université Grenoble Alpes, 2020. https://thares.univ-grenoble-alpes.fr/2020GRALV024.pdf.

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Pendant le développement, les projections axonales à longue distance se ramifient pour se connecter à leurs cibles. L’établissement et le remodelage de ces connexions est notamment régulé par l’activité neuronale. L’adaptation de la morphologie de l’axone nécessite alors des quantités importantes de matériel sécrétoire et de facteur trophiques comme le BDNF (brain derived neurotrophic factor). Ce matériel est transporté dans des vésicules le long de l’axone depuis le corps cellulaire où il est synthétisé, vers les sites actifs à l’extrémité de l’axone. Si le relargage de vésicules sécrétoires

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22

Holfelder, Christina Ingrid. "Effects of the glutamic acid decarboxylase (GAD) inhibitor semicarbazide and anti-GAD autoantibodies-containing immunoglobulin G on neuronal network activity within the motor cortex." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-123547.

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23

Kuebler, Eric Stephen. "Harnessing the Variability of Neuronal Activity: From Single Neurons to Networks." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37855.

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Neurons and networks of the brain may use various strategies of computation to provide the neural substrate for sensation, perception, or cognition. To simplify the scenario, two of the most commonly cited neural codes are firing rate and temporal coding, whereby firing rates are typically measured over a longer duration of time (i.e., seconds or minutes), and temporal codes use shorter time windows (i.e., 1 to 100 ms). However, it is possible that neurons may use other strategies. Here, we highlight three methods of computation that neurons, or networks, of the brain may use to encode and/or

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Rüppell, Maximilian Alexander [Verfasser], and Ulrich [Akademischer Betreuer] Egert. "Single neuron dynamics and interaction in neuronal networks during synchronized spontaneous activity." Freiburg : Universität, 2019. http://d-nb.info/1237617685/34.

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25

Picardo, Michel. "Origine embryonnaire et propriétés morpho-physiologiques des neurones hubs de l'hippocampe en développement." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM4057.

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Nous avons récemment mis en évidence des neurones GABAergiques jouant un rôle de « hub » dans l'hippocampe immature, orchestrant la synchronisation neuronale via une arborisation axonale dense. Dans ma thèse, j'ai d'abord montré, grâce à des enregistrements électrophysiologiques par paires, que les hubs étaient connectés à de nombreux neurones par des synapses GABAergiques fonctionnelles (Bonifazi et al. 2009). Puis, en utilisant des souris mutantes conditionnelles où les neurones sont marqués en fonction de leur origine embryonnaire, j'ai démontré que les neurones GABAergiques générés le plus

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26

Kane, Abdoul. "Activity propagation in two-dimensional neuronal networks." Columbus, Ohio : Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1133461090.

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Vignes, Maéva. "Development and activity of in vitro neuronal networks : learning organic chemistry through games." Thesis, Paris 5, 2013. http://www.theses.fr/2013PA05T080/document.

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Ma thèse comporte deux grandes parties, la première en biophysique et la seconde en science de l’éducation. La première partie présente des travaux à la frontière entre neurobiologie et microfluidique. Le but de ces travaux est de pouvoir reconstruire et étudier des réseaux complexes de neurones in vitro avec une topologie de connections synaptiques bien contrôlées. Une série de micro-structures mécanique et/ou chimique ont été étudiées pour leur capacité à (i) positionner les corps cellulaires des neurones, (ii) orienter la pousse des neurites, et (iii) différencier les axones des dendrites.

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Chauvet, Pierre. "Sur la stabilité d'un réseau de neurones hiérarchique à propos de la coordination du mouvement." Angers, 1993. http://www.theses.fr/1993ANGE0011.

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Dans le premier chapitre, quelques réseaux de neurones capables d'apprendre des mouvements sont présentés. Un modèle du cortex cérébelleux, très impliqué dans la coordination des mouvements, est décrit en détail : c'est un réseau hiérarchique de réseaux de neurones linéaires, appelés unités de Purkinje, qui respectent la connectivité réelle. Les poids synaptiques, en apprentissage, sont modifiés par une règle de covariance. L'étude de ce modèle a permis de définir de nouvelles règles d'apprentissage appelées règles d'apprentissage variationnelles. L'objectif de cette thèse est d'en étudier les

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Guzulaitis, Robertas. "The organisation principles of spinal neural network: temporal integration of somatosensory input and distribution of network activity." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2013. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130925_093153-76748.

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Spinal cord integrates somatosensory information and generates coordinated motor responses. Temporal integration can be used for discrimination of important stimuli from noise. Here it is shown that temporal integration of somatosensory inputs in sub second time scale is possible without changes of intrinsic properties of motoneurons. The activity of premotor neurons increases during temporal integration and can be a mechanism for short term information storage in spinal cord. Suppression of motor activity after painful somatosensory stimulus is called cutaneous silent period. This motor suppr

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MUZZI, LORENZO. "Development of engineered human-derived brain-on-a-chip models for electrophysiological recording." Doctoral thesis, Università degli studi di Genova, 2022. http://hdl.handle.net/11567/1091007.

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The study of the central nervous system represents a great challenge in the field of neuroscience. For years, various techniques have been developed to study neuronal cells in-vitro as it is difficult to conduct in-vivo experiments due to ethical problems deriving from its anatomical location. Consequently, both in-vivo and in-vitro animal models have been used extensively to gain new insights into basic functioning principles of neuronal tissue and therapeutic approaches for brain diseases. Over time, we have seen that there is a poor correlation between the clinical diagnosis and the underly

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Yger, Pierre. "Chaos control and plasticity in large scale neuronal networks with ongoing activity." Paris 11, 2010. http://www.theses.fr/2010PA112362.

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Comprendre comment s'organisent et fonctionnent les aires sensorielles primaires du neocortex est une étape cruciale pour l'analyse des mécanismes sous tendant le fonctionnement, d'un point de vue algorithmique, de l'activité cérébrale. Cette compréhension de la dynamique sensorielle passe par l'utilisation de modèles de neurones simplifiés, du type "intègre et tire", et par un cadre de travail particulier, celui du réseau "balancé", permettant de se placer dans un régime proche de ceux observés dans l'activité spontanée in vivo, où les neurones déchargent de façon irrégulière et à basse fréqu

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Adams, Natalie. "Quantifying activity in nascent neuronal networks derived from embryonic stem cells." Thesis, University of Newcastle Upon Tyne, 2013. http://hdl.handle.net/10443/1860.

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The relationship between spatiotemporal patterns of spontaneous activity and functional specialisation in developing neuronal networks is complex and its study is crucial to our understanding of how network communication is initiated. This project quantifies transitions between structural and functional states in embryonic stem cell cultures during differentiation. The work also focussed on the role of γ-aminobutyric acid (GABA), known to be vital for neuronal network development. The work used many techniques, including carbon nanotube (CNT) -patterned substrates to manipulate network archite

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Moretti, Daniela. "Exposure of neuronal networks to GSM mobile phone signals." Phd thesis, Université Sciences et Technologies - Bordeaux I, 2013. http://tel.archives-ouvertes.fr/tel-00949371.

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The central nervous system is the most likely target of mobile telephony radiofrequency field (RF) exposure in terms of biological effects. Several EEG (electroencephalography) studies have reported variations in the alpha-band power spectrum during and/or after RF exposure, in resting EEG and during sleep. In this context, the observation of the spontaneous electrical activity of neuronal networks under RF exposure can be an efficient tool to detect the occurrence of low-level RF effects on the nervous system. In this thesis research work we developed a dedicated experimental setup in the GHz

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Gezelius, Henrik. "Studies of Spinal Motor Control Networks in Genetically Modified Mouse Models." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-109889.

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MONGILLO, GIANLUIGI. "Learning dynamics leading to persistent activity in recurrent networks of spiking neurons." Doctoral thesis, La Sapienza, 2005. http://hdl.handle.net/11573/917155.

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Belloir, Tiphaine. "Dispositif électro-optique à base de cristaux liquides pour la détection de l'activité neuronale in vitro." Thesis, Université Grenoble Alpes (ComUE), 2018. https://thares.univ-grenoble-alpes.fr/2018GREAT122.pdf.

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Les réseaux de neurones in-vitro permettent de modéliser les structures et les fonctions observées dans le cerveau humain. Accéder à l’activité individuelle des neurones sur l’ensemble d’un réseau est un réel défi en neuroscience pour mieux comprendre la complexité des processus qui régissent la communication neuronale. Les techniques actuelles d’enregistrement in vitro (électrophysiologie, imagerie calcique ou encore MicroElectrode ARray) souffrent d’un compromis systématique entre la résolution et la quantité de neurones détectables simultanément (i.e. le champ d’observation).L’objectif de c

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Baker, Pamela Mary. "Modulation of oscillatory activity in inhibitory neuronal networks by anesthetics, the role of receptor desensitization." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ63190.pdf.

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Kühn, Tobias Verfasser], Moritz [Akademischer Betreuer] Helias, and Carsten [Akademischer Betreuer] [Honerkamp. "Path integral methods for correlated activity in neuronal networks / Tobias Kühn ; Moritz Helias, Carsten Honerkamp." Aachen : Universitätsbibliothek der RWTH Aachen, 2019. http://d-nb.info/1221697404/34.

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Kühn, Tobias [Verfasser], Moritz Akademischer Betreuer] Helias, and Carsten [Akademischer Betreuer] [Honerkamp. "Path integral methods for correlated activity in neuronal networks / Tobias Kühn ; Moritz Helias, Carsten Honerkamp." Aachen : Universitätsbibliothek der RWTH Aachen, 2019. http://d-nb.info/1221697404/34.

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Dreosti, Elena. "Imaging synaptic activity of neuronal networks in vitro and in vivo using a fluorescent calcium indicator." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608931.

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Dylda, Evelyn. "Neuronal circuits of experience-dependent plasticity in the primary visual cortex." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31234.

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Our ability to learn relies on the potential of neuronal networks to change through experience. The primary visual cortex (V1) has become a popular system for studying how experience shapes cortical neuronal networks. Experience-dependent plasticity in V1 has been extensively studied in young animals, revealing that experiences in early postnatal life substantially shape neuronal activity in the developing cortex. In contrast, less is known about how experiences modify the representation of visual stimuli in the adult brain. In addition, adult experience-dependent plasticity remains largely un

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Kähne, Malte [Verfasser], Sten [Gutachter] Rüdiger, Alexandre [Gutachter] Kihara, and Jorge [Gutachter] Mejias. "Population activity and waves in neuronal networks / Malte Kähne ; Gutachter: Sten Rüdiger, Alexandre Kihara, Jorge Mejias." Berlin : Humboldt-Universität zu Berlin, 2020. http://d-nb.info/1204426872/34.

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Mazzoni, Alberto. "From neuronal networks to behavior: dynamics of spontaneous activity and onset of movement in the leech." Doctoral thesis, SISSA, 2007. http://hdl.handle.net/20.500.11767/4000.

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Animal behavior was once seen as a chain of reactions to stimuli from the environment. From chemotaxis in bacteria to mammals withdrawing from painful stimuli, most of the actions taken by animals are clearly driven by external inputs. Reflexes were among the first phenomena to be studied to have an insight on the dynamics of the nervous system. Later, a step forward was the discovery of central pattern generators: once a behavior is started by a stimulus, some neuronal networks are able to maintain it without further inputs from the environment. The nervous system of all animals, howeve

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Kordovan, Michael [Verfasser], and Stefan [Akademischer Betreuer] Rotter. "Constraints on neural activity imposed by the structure of neurons and networks." Freiburg : Universität, 2019. http://d-nb.info/1185391266/34.

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Wheeler, Damian George. "Monitoring CRE-dependent Gene Expression Induced by Synaptic Activity in Live Networks of Neurons." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=95597.

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During development, neuronal activity plays an important role in shaping functionalsynaptic networks. Moreover, in adults, neuronal activity is thought to produce long-termchanges during learning and memory. For these changes to persist, however, neuronalactivity must engage signaling pathways that result in alterations in gene expression.Pathways that activate the transcription factor CREB (cAMP-response element-bindingprotein), which binds to CREs (cAMP response elements) in gene promoters, have beenimplicated in this long-term, activity-dependent plasticity. The focus of my research is toin

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Fitoussi, Aurélie. "Marqueurs comportementaux et corrélats neurobiologiques de la prise de décision adaptée et inadaptée chez le rat." Thesis, Bordeaux 2, 2011. http://www.theses.fr/2011BOR21871.

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Une prise de décision inadaptée est au centre de nombreuses pathologies neuropsychiatriques, telle que la toxicomanie, mais concerne également certains sujets sains, pour lesquels les gratifications immédiates prévalent sur les conséquences à long terme. Afin de mieux comprendre les bases neuropsychologiques et neurobiologiques de la prise de décision dans un cadre normal et pathologique, les sujets sains inadaptés constituent un modèle prometteur. Une tâche de mesure de la prise de décision chez le rat (le Rat Gambling Task, RGT) a récemment été validée dans l’équipe, très similaire à l’Iowa

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Louçã, Mathilde. "Functional impacts of Huntingtin lowering on the synaptic maturation and activity of neuronal networks derived from human induced pluripotent stem cells." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL054.

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La maladie de Huntington (MH) est une maladie neurodégénérative causée par la mutation de la Huntingtine (HTT). La réduction de l'expression de la HTT mutante est une piste thérapeutique évidente en cours d’exploration chez les patients. Le ciblage de la HTT mutante s’accompagne cependant le plus souvent d’une réduction concomitante de la HTT non mutée. Les conséquences de la perte de cette protéine sur la santé des neurones restent mal connues.Mon travail de thèse traite cette question en utilisant des modèles in vitro de réseaux neuronaux humains différenciés à partir de cellules souches ind

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Sieling, Fred H. "Prediction and control of patterned activity in small neural networks." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/37105.

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Rhythmic neural activity is thought to underlie many high-level functions of the nervous system. Our goals are to understand rhythmic activity starting with small networks, using theoretical and experimental tools. Phase resetting theory describes essential properties that cause and destroy rhythms. We validate and extend one branch of this theory, testing it in bursting neurons coupled by excitation and then extending the theory to account for temporal variability found in our experimental data. We show that the theory makes good predictions of rhythmic activity in heterogeneous networks. We

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Bammann, Rodrigo Roberto. "Differential effects of serotonin and nitric oxide on the intrinsic properties and network activity of cortical neurons." Thesis, University of Leicester, 2015. http://hdl.handle.net/2381/31981.

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Serotonin (5HT) and nitric oxide (NO) are important signalling molecules with roles in behavioural control and various psychological conditions. Various lines of evidence suggest interactions between 5HT and NO signalling, however little is known about their interaction in modulating intrinsic properties of cortical neurons and the effects on the neuronal network activity in the cortex. This project studied the effects of 5HT and NO on cultured neurons isolated from Wistar rat cortices. 5HT and NO produced diverse responses in cortical neurons, reflecting the heterogeneity of cortical neuron t

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Shao, Jie. "Putative Role of Connectivity in the Generation of Spontaneous Bursting Activity in an Excitatory Neuron Population." Thesis, Georgia Institute of Technology, 2004. http://hdl.handle.net/1853/5086.

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Population-wide synchronized rhythmic bursts of electrical activity are present in a variety of neural circuits. The proposed general mechanisms for rhythmogenesis are often attributed to intrinsic and synaptic properties. For example, the recurrent excitation through excitatory synaptic connections determines burst initiation, and the slower kinetics of ionic currents or synaptic depression results in burst termination. In such theories, a slow recovery process is essential for the slow dynamics associated with bursting. This thesis presents a new hypothesis that depends on the connecti

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