Academic literature on the topic 'Neuronal nitric oxide synthase (nNOS)'

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Journal articles on the topic "Neuronal nitric oxide synthase (nNOS)"

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Kourosh-Arami, Masoumeh, Nasrin Hosseini, Monireh Mohsenzadegan, Alireza Komaki, and Mohammad Taghi Joghataei. "Neurophysiologic implications of neuronal nitric oxide synthase." Reviews in the Neurosciences 31, no. 6 (August 27, 2020): 617–36. http://dx.doi.org/10.1515/revneuro-2019-0111.

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AbstractThe molecular and chemical properties of neuronal nitric oxide synthase (nNOS) have made it a key mediator in many physiological functions and signaling transduction. The NOS monomer is inactive, but the dimer form is active. There are three forms of NOS, which are neuronal (nNOS), inducible (iNOS), and endothelial (eNOS) nitric oxide synthase. nNOS regulates nitric oxide (NO) synthesis which is the mechanism used mostly by neurons to produce NO. nNOS expression and activation is regulated by some important signaling proteins, such as cyclic adenosine monophosphate (cAMP) response elem
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Huber, Andrea, Dieter Saur, Manfred Kurjak, Volker Schusdziarra, and Hans-Dieter Allescher. "Characterization and splice variants of neuronal nitric oxide synthase in rat small intestine." American Journal of Physiology-Gastrointestinal and Liver Physiology 275, no. 5 (November 1, 1998): G1146—G1156. http://dx.doi.org/10.1152/ajpgi.1998.275.5.g1146.

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The aim of this study was to characterize neuronal nitric oxide synthase (nNOS) activity and 5′-end splice variants in rat small intestine. nNOS was predominantly expressed in the longitudinal muscle layer, with attached myenteric plexus (LM-MP). The biochemical properties of NOS activity in enriched nerve terminals resemble those of nNOS isolated from the brain. Western blot analysis of purified NOS protein with an nNOS antibody showed a single band in the particulate fraction and three bands in the soluble fraction. Rapid amplification of 5′ cDNA ends-PCR revealed the presence of three diffe
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Rao, Y. Manjula, Arun Chaudhury, and Raj K. Goyal. "Active and inactive pools of nNOS in the nerve terminals in mouse gut: implications for nitrergic neurotransmission." American Journal of Physiology-Gastrointestinal and Liver Physiology 294, no. 3 (March 2008): G627—G634. http://dx.doi.org/10.1152/ajpgi.00519.2007.

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Nitric oxide (NO) is responsible for nitrergic neurotransmission in the gut, and its release is dependent on its de novo synthesis by neuronal nitric oxide synthase (nNOS). The magnitude of NO synthesis and release during neurotransmission may be related to the fraction of catalytically active nNOS out of a larger pool of inactive nNOS in the nerve terminals. The purpose of the present study was to identify catalytically active and inactive pools of nNOS in the varicosities from mouse gut. Enteric varicosities were confirmed as nitrergic by colocalization of nNOS with the nerve varicosity mark
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Di Giacomo, C., V. Sorrenti, L. Salerno, V. Cardile, F. Guerrera, M. A. Siracusa, M. Avitabile, and A. Vanella. "Novel Inhibitors of Neuronal Nitric Oxide Synthase." Experimental Biology and Medicine 228, no. 5 (May 2003): 486–90. http://dx.doi.org/10.1177/15353702-0322805-11.

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Selective inhibitors of neuronal nitric oxide synthase (nNOS), which are devoid of any effect on the endothelial isoform (eNOS), may be required for the treatment of some neurological disorders. In our search for novel nNOS inhibitors, we recently described some 1-[(Aryloxy)ethyl]-1 H-imidazoles as interesting molecules for their selectivity for nNOS against eNOS. This work reports a new series of 1-[(Aryloxy)alkyl]-1 H-imidazoles in which a longer methylene chain is present between the imidazole and the phenol part of molecule. Some of these molecules were found to be more potent nNOS inhibit
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YONEYAMA, Hirohito, Akira YAMAMOTO, and Hiroaki KOSAKA. "Neuronal nitric oxide synthase generates superoxide from the oxygenase domain." Biochemical Journal 360, no. 1 (November 8, 2001): 247–53. http://dx.doi.org/10.1042/bj3600247.

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When l-arginine is depleted, neuronal nitric oxide synthase (nNOS) has been reported to generate superoxide. A flavoprotein module construct of nNOS has been demonstrated to be sufficient for superoxide production. In contrast, nNOS was reported not to be involved in superoxide formation, because such formation occurred with a mixture of the boiled enzyme and redox-active cofactors. We aimed to resolve these controversial issues by examining superoxide generation, without the addition of redox-active cofactors, by recombinant wild-type nNOS and by C415A-nNOS, which has a mutation in the haem p
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González-Martínez, Jorge A., Gabriel Möddel, Zhong Ying, Richard A. Prayson, William E. Bingaman, and Imad M. Najm. "Neuronal nitric oxide synthase expression in resected epileptic dysplastic neocortex." Journal of Neurosurgery 110, no. 2 (February 2009): 343–49. http://dx.doi.org/10.3171/2008.6.17608.

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Object Nitric oxide has been associated with epileptogenesis. Previous studies have shown increased expression of N-methyl-d-aspartate (NMDA) subunit NR2B receptors in epileptic dysplastic human neocortex. The expression of neuronal nitric oxide synthase (nNOS), and its relation to this subunit NR2B in epileptic dysplastic tissue has never been addressed. Methods Ten patients with medically intractable epilepsy caused by focal cortical dysplasia (CD), and 2 patients with mesial temporal sclerosis (control group) underwent pre- and/or intraoperative invasive monitoring evaluations. Cortical sam
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Premaratne, Shyamal, Chun Xue, John M. McCarty, Muhammad Zaki, Robert W. McCuen, Roger A. Johns, Wolfgang Schepp, et al. "Neuronal nitric oxide synthase: expression in rat parietal cells." American Journal of Physiology-Gastrointestinal and Liver Physiology 280, no. 2 (February 1, 2001): G308—G313. http://dx.doi.org/10.1152/ajpgi.2001.280.2.g308.

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Nitric oxide synthases (NOS) are enzymes that catalyze the generation of nitric oxide (NO) from l-arginine and require nicotinamide adenine dinucleotide phosphate (NADPH) as a cofactor. At least three isoforms of NOS have been identified: neuronal NOS (nNOS or NOS I), inducible NOS (iNOS or NOS II), and endothelial NOS (eNOS or NOS II). Recent studies implicate NO in the regulation of gastric acid secretion. The aim of the present study was to localize the cellular distribution and characterize the isoform of NOS present in oxyntic mucosa. Oxyntic mucosal segments from rat stomach were stained
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ROCZNIAK, AGNES, JAMES N. FRYER, DAVID Z. LEVINE, and KEVIN D. BURNS. "Downregulation of Neuronal Nitric Oxide Synthase in the Rat Remnant Kidney." Journal of the American Society of Nephrology 10, no. 4 (April 1999): 704–13. http://dx.doi.org/10.1681/asn.v104704.

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Abstract. Chronic renal failure is associated with disturbances in nitric oxide (NO) production. This study was conducted to determine the effect of 5/6 nephrectomy (5/6 Nx) on expression of intrarenal neuronal nitric oxide synthase (nNOS) in the rat. In normal rat kidney, nNOS protein was detected in the macula densa and in the cytoplasm and nuclei of cells of the inner medullary collecting duct by both immunofluorescence and electron microscopy. Western blot analysis revealed that 2 wk after 5/6 Nx, there were significant decreases in nNOS protein expression in renal cortex (sham: 95.42 ± 15
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Wang, Xianhong, Ming Lu, Yongzong Gao, Andreas Papapetropoulos, William C. Sessa, and Wenhui Wang. "Neuronal nitric oxide synthase is expressed in principal cell of collecting duct." American Journal of Physiology-Renal Physiology 275, no. 3 (September 1, 1998): F395—F399. http://dx.doi.org/10.1152/ajprenal.1998.275.3.f395.

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We used the RT-PCR technique and immunocytochemical methods to determine the expression of endothelial nitric oxide synthase (eNOS) or neuronal nitric oxide synthase (nNOS) in the cortical collecting duct (CCD) in rats on high-K+ diet. The microdissected CCDs of the rat kidney were lysed, and RT-PCR was carried out using rat nNOS and eNOS gene-specific primers. Southern analysis showed the presence of mRNA of nNOS but not eNOS in the CCD. The presence of nNOS in the CCD was further confirmed by light microscopy. We used the polyclonal nNOS antibody in immunocytochemical studies of the isolated
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Smith, Cheryl A., Beth Santymire, Aaron Erdely, Vasuki Venkat, György Losonczy, and Chris Baylis. "Renal nitric oxide production in rat pregnancy: role of constitutive nitric oxide synthases." American Journal of Physiology-Renal Physiology 299, no. 4 (October 2010): F830—F836. http://dx.doi.org/10.1152/ajprenal.00300.2010.

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Functional studies show that increased renal nitric oxide (NO) mediates the renal vasodilation and increased glomerular filtration rate that occur during normal pregnancy. We investigated whether changes in the constitutive NO synthases (NOS), endothelial (eNOS) and neuronal (nNOS), were associated with the increased renal NO production in normal midterm pregnancy in the rat. In kidneys from midterm pregnant (MP: 11–13 days gestation), late-term pregnant (LP: 18–20 days gestation), and similarly aged virgin (V) rats, transcript and protein abundance for eNOS and the nNOSα and nNOSβ splice vari
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Dissertations / Theses on the topic "Neuronal nitric oxide synthase (nNOS)"

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Cheung, Nathan Yiutung. "Serotonin receptor and neuronal nitric oxide synthase expression in the rat brain : implications for MDMA toxicity." Thesis, King's College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368095.

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Lu, Chieh-Ju. "Neuronal nitric oxide synthase-CAPON regulation of cardiac sympathetic activity in the development of hypertension." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:1204dec9-9f09-458d-b361-c8d14589fcd1.

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The studies presented in this thesis were undertaken to investigate the cellular and molecular mechanisms responsible for sympathetic hyperactivity that is observed in the Spontaneous Hypertensive Rat (SHR) and whether these abnormalities arise even before the onset of hypertension. Moreover, selected molecular candidates related to oxidative state in cardiac autonomic signalling have been explored for their potential therapeutic effects. <b>Chapter One</b> is an overview of (i) the relevance of autonomic dysfunction in cardiovascular disease in both human and animal models, (ii) the physiolog
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Bird, Diane Carol. "An investigation into the role of neuronal nitric oxide synthase (nNOS) in the phencyclidine mouse model of schizophrenia." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0015/MQ57249.pdf.

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Barua, Anupama. "The role of neuronal nitric oxide synthase (nNOS) in ischaemia/reoxygenation-induced injury and in protection of the mammalian myocardium." Thesis, University of Leicester, 2010. http://hdl.handle.net/2381/8754.

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Background: In physiological condition, NO is produced by two constitutive NOS isoform; eNOS and nNOS. Both isoforms have specific cellular locations and although the role of eNOS in myocardial ischaemic injury and in cardioprotection has been thoroughly addressed, but the role of nNOS remains unclear. Therefore, the aims of the thesis were to: (i) investigate the role of nNOS in ischaemia/reoxygenation-induced injury, (ii) determine whether its effect is species-dependent, (iii) elucidate the relationship of nNOS with mitoKATP channels and p38MAPK, two key components of IP and (iv) investigat
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Balda, Mara A. "Ontogeny- and Sex-Dependent Contributions of the Neuronal Nitric Oxide Synthase (nNOS) Gene to Rewarding and Psychomotor Stimulating Effects of Cocaine." Scholarly Repository, 2009. http://scholarlyrepository.miami.edu/oa_dissertations/257.

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Multiple interactions between dopamine (DA), glutamate, and nitric oxide (NO) in mesolimbic and corticostriatal circuits suggest that NO may play a critical role in cocaine-induced behavioral and neural plasticity. Clinical and preclinical studies have revealed that females and adolescents display unique vulnerabilities to the behavioral and neurochemical effects of cocaine as a result of sex-dependent and ontogeny-dependent differences in dopaminergic systems. Thus, my research objectives were to investigate the contributions of the neuronal nitric oxide synthase (nNOS) gene, ontogeny, and g
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Schonhoff, Christopher M. "The Regulation of nNOS During Neuronal Differentiation and the Effect of Nitric Oxide on Hdm2-p53 Binding: a Dissertation." eScholarship@UMMS, 2000. https://escholarship.umassmed.edu/gsbs_diss/57.

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Nitric oxide is a ubiquitous signaling molecule with both physiological and pathological functions in biological systems. Formed by the enzymatic conversion of arginine to citrulline, NO, has known roles in circulatory, immune and nervous tissues. In the nervous system nitric oxide has been implicated in long-term potentiation, neurotransmitter release, channel function, neuronal protection and neuronal degeneration. Much of our work has focused on yet another role for nitric oxide in cells, namely, neuronal differentiation. During development, neuronal differentiation is closely coupled with
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Silva, Maria Isabel. "Distribuição de celulas imunorreativas para sintase neuronal do oxido nitrico (nNOS) no hipocampo de pombos (Columba livia) apos aprendizagem de escolha alimentar." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314142.

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Orientadores: Elenice Aparecida de Moraes Ferrari, Claudio Antonio Barbosa de Toledo<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-10T10:38:58Z (GMT). No. of bitstreams: 1 Silva_MariaIsabel_M.pdf: 1381550 bytes, checksum: 9cb336aef794086ff363f071f8040818 (MD5) Previous issue date: 2007<br>Resumo: O hipocampo exerce papel fundamental no processamento de aprendizagem e memória espaciais. Comparações das características funcionais, anatômicas e neuroquímicas do hipocampo são favorecidas por evidência oriunda de estudo
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Denadai, Magda Aline. "Efeitos do 7-nitroindazole, um inibidor da sintase neuronal do oxido nitrico (nNOS), sobre o condiciomaneto contextural em pombos." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314745.

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Orientador: Elenice Aparecida de Moraes Ferrari<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-11T20:16:54Z (GMT). No. of bitstreams: 1 Denadai_MagdaAline_M.pdf: 823511 bytes, checksum: 1887972f9e5047fecbd7195247b586a8 (MD5) Previous issue date: 2008<br>Resumo: O óxido nítrico (NO), um neurotransmissor não convencional, tem papel importante em processos neurobiológicos de comportamento e de memória. Sua síntese é mediada por três isoformas de sintase do óxido nítrico (NOS): a neuronal (nNOS), a endotelial (eNOS) e i
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Machado, Aline Vilar da Silva. "Variação circadiana da expressão da sintase neuronal de óxido nítrico (nNOS) no hipocampo e o condicionamento contextual aversivo em pombos (Columba livia)." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314744.

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Orientador: Elenice Aparecida de Moraes Ferrari<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-18T00:49:19Z (GMT). No. of bitstreams: 1 Machado_AlineVilardaSilva_M.pdf: 2487506 bytes, checksum: ec15fc1b78bef814d6d459499276cdf5 (MD5) Previous issue date: 2011<br>Resumo: A ritmicidade circadiana, expressa na alteração do comportamento e em aspectos morfofisiológicos e moleculares ao longo das 24 horas do dia, é uma das funções básicas dos organismos vivos. Os processos comportamentais e os mecanismos moleculares no hi
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Faria, Larissa Oliveira Melloni de 1985. "Participação da sintase neuronal de óxido nítrico (nNOS) na consolidação e reconsolidação da memória do condicionamento clássico aversivo em pombos (Columba livia)." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314128.

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Orientador: Elenice Aparecida de Moraes Ferrari<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-23T06:24:39Z (GMT). No. of bitstreams: 1 Faria_LarissaOliveiraMellonide_M.pdf: 1121073 bytes, checksum: 5a3108ca0447b5fae98988b4611d7616 (MD5) Previous issue date: 2013<br>Resumo: O óxido nítrico (NO) é um neurotransmissor não convencional o qual tem papel importante em processos neurobiológicos de comportamento e de memória. Sua síntese é mediada por três isoformas de sintase do óxido nítrico (NOS): a neuronal (nNOS), a e
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Books on the topic "Neuronal nitric oxide synthase (nNOS)"

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McLaren, Anya T. Increased expression of hypoxia inducible factor-1alpha (HIF-1alpha) and neuronal nitric oxide synthase (nNOS) in the cerebral cortex of anemic rats. 2006.

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Newton, Derek Colin. The human neuronal nitric oxide synthase gene: RNA biology guiding expressional regulation. 2004.

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Book chapters on the topic "Neuronal nitric oxide synthase (nNOS)"

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Tiro, Jasmin, Simon J. Craddock Lee, Steven E. Lipshultz, Tracie L. Miller, James D. Wilkinson, Miriam A. Mestre, Barbara Resnick, et al. "Neuronal Nitric Oxide Synthase (nNOS)." In Encyclopedia of Behavioral Medicine, 1326. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1005-9_101144.

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Saini, Rashmi, Zaffar Azam, Leena Sapra, and Rupesh K. Srivastava. "Neuronal Nitric Oxide Synthase (nNOS) in Neutrophils: An Insight." In Reviews of Physiology, Biochemistry and Pharmacology, 49–83. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/112_2021_61.

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Pichiule, P., J. C. Chavez, R. J. Przybylski, and J. C. LaManna. "Increase of Neuronal Nitric Oxide Synthase during Chronic Hypoxia." In Oxygen Transport to Tissue XX, 319–23. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-4863-8_37.

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Prabhakar, Nanduri R., Shobha Rao, David Premkumar, Sean F. Pieramici, Ganesh K. Kumar, and Rajesh K. Kalaria. "Regulation of Neuronal Nitric Oxide Synthase Gene Expression by Hypoxia." In Frontiers in Arterial Chemoreception, 345–48. Boston, MA: Springer US, 1996. http://dx.doi.org/10.1007/978-1-4615-5891-0_53.

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Kitamura, M., H. Matsuda, S. Kimura, and T. Iyanagi. "One-Electron Reduction of Quinones by the Neuronal Nitric-Oxide Synthase Reductase Domain." In Advances in Experimental Medicine and Biology, 323–26. Boston, MA: Springer US, 2001. http://dx.doi.org/10.1007/978-1-4615-0667-6_50.

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Rokutan, Kazuhito, Shigetada Teshima, Tomoko Kawai, Tsukasa Kawahara, Kenji Kusumoto, and Kyoichi Kishi. "Regulation of Mucin Synthesis by Neuronal Nitric Oxide Synthase in Gastric Pit Cells." In Trends in Gastroenterology and Hepatology, 90–94. Tokyo: Springer Japan, 2001. http://dx.doi.org/10.1007/978-4-431-67895-3_15.

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Li, Yi-Fan, Yu Wang, Keith M. Channon, Harold D. Schultz, Irving H. Zucker, and Kaushik P. Patel. "Manipulation of Neuronal Nitric Oxide Synthase Within the Paraventricular Nucleus Using Adenovirus and Antisense Technology." In Molecular Cardiology, 59–79. Totowa, NJ: Humana Press, 2005. http://dx.doi.org/10.1385/1-59259-879-x:059.

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Ding, Chuanqing, Benjamin Walcott, and Kent T. Keyser. "Neuronal Nitric Oxide Synthase is Expressed in the Mouse Lacrimal Gland and Neurons of Pterygopalatine Ganglion." In Advances in Experimental Medicine and Biology, 91–95. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/978-1-4615-0717-8_11.

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Masters, B. S. S., K. McMillan, J. Nishimura, P. Martasek, L. J. Roman, E. Sheta, S. S. Gross, and J. Salerno. "Understanding the Structural Aspects of Neuronal Nitric Oxide Synthase (NOS) Using Microdissection by Molecular Cloning Techniques." In Advances in Experimental Medicine and Biology, 163–69. Boston, MA: Springer US, 1996. http://dx.doi.org/10.1007/978-1-4757-9480-9_22.

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Migita, Catharina Taiko, John C. Salerno, Bettie Sue Siler Masters, and Masao Ikeda-Saito. "Electron Paramagnetic Resonance Studies on Substrate Binding to the NO Complex of Neuronal Nitric Oxide Synthase." In Oxygen Homeostasis and Its Dynamics, 298–303. Tokyo: Springer Japan, 1998. http://dx.doi.org/10.1007/978-4-431-68476-3_37.

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Conference papers on the topic "Neuronal nitric oxide synthase (nNOS)"

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Jackson, Claire L., Jacqueline King, Edith N. Quinn, Peter M. Lackie, and Jane S. Lucas. "The Importance Of Being NNOS? Unique Localization Of Neuronal Nitric Oxide Synthase To Cilia And Investigating A Nitric Oxide Synthase-1 Polymorphism In Primary Ciliary Dyskinesia." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a5504.

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Razee, A., S. Banerjee, M. Zargari, J. Hong, and S. Umar. "Intrathecal Neuronal Nitric Oxide Synthase Inhibition Attenuates Pulmonary Hypertension and Rescues Right Ventricular Failure in Rats." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3692.

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Pineda, Joseba, Patricia Pablos, and Aitziber Mendiguren. "Effect of neuronal nitric oxide synthase inhibitors and antioxidants on the development of tolerance by different opioid agonists in the rat locus coeruleus." In MOL2NET, International Conference on Multidisciplinary Sciences. Basel, Switzerland: MDPI, 2015. http://dx.doi.org/10.3390/mol2net-1-b022.

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