Relevant bibliographies by topics / Neurons. Ligands (Biochemistry)

Contents

  1. Journal articles
  2. Dissertations / Theses

Academic literature on the topic 'Neurons. Ligands (Biochemistry)'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Neurons. Ligands (Biochemistry).'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Neurons. Ligands (Biochemistry)"

1

Fantin, Alessandro, Charlotte H. Maden, and Christiana Ruhrberg. "Neuropilin ligands in vascular and neuronal patterning." Biochemical Society Transactions 37, no. 6 (November 19, 2009): 1228–32. http://dx.doi.org/10.1042/bst0371228.

Full text
Abstract:
Blood vessels and neurons share guidance cues and cell-surface receptors to control their behaviour during embryogenesis. The transmembrane protein NRP1 (neuropilin 1) is present on both blood vessels and nerves and binds two structurally diverse ligands, the class 3 semaphorin SEMA3A and an isoform of the vascular endothelial growth factor VEGF-A termed VEGF165 (VEGF164 in mice). In vitro, SEMA3A competes with VEGF164 for binding to NRP1 to modulate the migration of endothelial cells and neuronal progenitors. It was therefore hypothesized that NRP1 signalling controls neurovascular co-patterning by integrating competing VEGF164 and SEMA3A signals. However, SEMA3A, but not VEGF164, is required for axon patterning of motor and sensory nerves, and, vice versa, VEGF164 rather than SEMA3A is required for blood vessel development. Ligand competition for NRP1 therefore does not explain neurovascular congruence. Instead, these ligands control different aspects of neurovascular patterning that have an impact on cardiovascular function. Thus SEMA3A/NRP1 signalling guides the NCC (neural crest cell) precursors of sympathetic neurons as well as their axonal projections. In addition, VEGF164 and a second class 3 semaphorin termed SEMA3C contribute to the remodelling of the embryonic pharyngeal arch arteries and primitive heart outflow tract by acting on endothelium and NCCs respectively. Consequently, loss of either of these NRP1 ligands disrupts blood flow into and out of the heart. Multiple NRP1 ligands therefore co-operate to orchestrate cardiovascular morphogenesis.
APA, Harvard, Vancouver, ISO, and other styles
2

Gomez, Natalia, Shaochen Chen, and Christine E. Schmidt. "Polarization of hippocampal neurons with competitive surface stimuli: contact guidance cues are preferred over chemical ligands." Journal of The Royal Society Interface 4, no. 13 (November 14, 2006): 223–33. http://dx.doi.org/10.1098/rsif.2006.0171.

Full text
Abstract:
Neuronal behaviour is profoundly influenced by extracellular stimuli in many developmental and regeneration processes. Understanding neuron responses and integration of environmental signals could impact the design of successful therapies for neurodegenerative diseases and nerve injuries. Here, we have investigated the influence of localized extracellular cues on polarization (i.e. axon formation) of hippocampal neurons. Electron-beam lithography, microfabrication techniques and protein immobilization were used to create a unique system that provided simultaneous and independent chemical and physical cues to individual neurons. In particular, we analysed competitive responses between simultaneous stimulation with chemical ligands, including immobilized nerve growth factor and laminin, and contact guidance cues mediated by surface topography (i.e. microchannels). Contact guidance cues were preferred 70% of the time over chemical ligands by neurons extending axons, which suggests a stronger stimulation mechanism triggered by topography. This investigation contributes to the understanding of neuronal behaviour on artificial substrates, which is applicable to the creation of artificial environments for neural engineering applications.
APA, Harvard, Vancouver, ISO, and other styles
3

Cho, Pyung Sun, Han Kyu Lee, Young In Choi, Seung In Choi, Ji Yeon Lim, Minseok Kim, Hyun Kim, Sung Jun Jung, and Sun Wook Hwang. "GPR171 Activation Modulates Nociceptor Functions, Alleviating Pathologic Pain." Biomedicines 9, no. 3 (March 5, 2021): 256. http://dx.doi.org/10.3390/biomedicines9030256.

Full text
Abstract:
Modulation of the function of somatosensory neurons is an important analgesic strategy, requiring the proposal of novel molecular targets. Many G-protein-coupled receptors (GPRs) have been deorphanized, but the receptor locations, outcomes due to their activations, and their signal transductions remain to be elucidated, regarding the somatosensory nociceptor function. Here we report that GPR171, expressed in a nociceptor subpopulation, attenuated pain signals via Gi/o-coupled modulation of the activities of nociceptive ion channels when activated by its newly found ligands. Administration of its natural peptide ligand and a synthetic chemical ligand alleviated nociceptor-mediated acute pain aggravations and also relieved pathologic pain at nanomolar and micromolar ranges. This study suggests that functional alteration of the nociceptor neurons by GPR171 signaling results in pain alleviation and indicates that GPR171 is a promising molecular target for peripheral pain modulation.
APA, Harvard, Vancouver, ISO, and other styles
4

Neuhaus, Eva M., Weiyi Zhang, Lian Gelis, Ying Deng, Joachim Noldus, and Hanns Hatt. "Activation of an Olfactory Receptor Inhibits Proliferation of Prostate Cancer Cells." Journal of Biological Chemistry 284, no. 24 (April 23, 2009): 16218–25. http://dx.doi.org/10.1074/jbc.m109.012096.

Full text
Abstract:
Olfactory receptors (ORs) are expressed not only in the sensory neurons of the olfactory epithelium, where they detect volatile substances, but also in various other tissues where their potential functions are largely unknown. Here, we report the physiological characterization of human OR51E2, also named prostate-specific G-protein-coupled receptor (PSGR) due to its reported up-regulation in prostate cancer. We identified androstenone derivatives as ligands for the recombinant receptor. PSGR can also be activated with the odorant β-ionone. Activation of the endogenous receptor in prostate cancer cells by the identified ligands evoked an intracellular Ca2+ increase. Exposure to β-ionone resulted in the activation of members of the MAPK family and inhibition of cell proliferation. Our data give support to the hypothesis that because PSGR signaling could reduce growth of prostate cancer cells, specific receptor ligands might therefore be potential candidates for prostate cancer treatment.
APA, Harvard, Vancouver, ISO, and other styles
5

Gomez-Diaz, Carolina, Jaime H. Reina, Christian Cambillau, and Richard Benton. "Ligands for Pheromone-Sensing Neurons Are Not Conformationally Activated Odorant Binding Proteins." PLoS Biology 11, no. 4 (April 30, 2013): e1001546. http://dx.doi.org/10.1371/journal.pbio.1001546.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Tamponnet, Christian, Sylvie Boisseau, Chantal Poujeol, Maurice Lievremont, and Michel Simonneau. "Calcium alginate immobilization of mammalian neurons: A potential tool to purify ligands of neuronal membrane proteins." Biotechnology Techniques 5, no. 4 (July 1991): 289–94. http://dx.doi.org/10.1007/bf02438665.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

del Zoppo, G. J., R. Milner, T. Mabuchi, S. Hung, X. Wang, and J. A. Koziol. "Vascular matrix adhesion and the blood–brain barrier." Biochemical Society Transactions 34, no. 6 (October 25, 2006): 1261–66. http://dx.doi.org/10.1042/bst0341261.

Full text
Abstract:
The integrity of the cerebral microvasculature depends on the interaction between its component cells and the extracellular matrix, as well as reorganized cell–cell interactions. In the central nervous system, matrix adhesion receptors are expressed in the microvasculature and by neurons and their supporting glial cells. Cells within cerebral microvessels express both the integrin and dystroglycan families of matrix adhesion receptors. However, the functional significance of these receptors is only now being explored. Endothelial cells and astrocytes within cerebral capillaries co-operate to generate and maintain the basal lamina and the unique barrier functions of the endothelium. Integrins and the dystroglycan complex are found on the matrix-proximate faces of both endothelial cells and astrocyte end-feet. Pericytes rest against the basal lamina. In the extravascular compartment, select integrins are expressed on neurons, microglial cells and oligodendroglia. Significant alterations in both cellular adhesion receptors and their matrix ligands occur during focal cerebral ischaemia, which support their functional significance in the normal state. We propose that matrix adhesion receptors are essential for the maintenance of the integrity of the blood–brain permeability barrier and that modulation of these receptors contributes to alterations in the barrier during brain injury.
APA, Harvard, Vancouver, ISO, and other styles
8

Vigneswara, Vasanthy, Sarina Kundi, and Zubair Ahmed. "Receptor Tyrosine Kinases: Molecular Switches Regulating CNS Axon Regeneration." Journal of Signal Transduction 2012 (July 16, 2012): 1–14. http://dx.doi.org/10.1155/2012/361721.

Full text
Abstract:
The poor or lack of injured adult central nervous system (CNS) axon regeneration results in devastating consequences and poor functional recovery. The interplay between the intrinsic and extrinsic factors contributes to robust inhibition of axon regeneration of injured CNS neurons. The insufficient or lack of trophic support for injured neurons is considered as one of the major obstacles contributing to their failure to survive and regrow their axons after injury. In the CNS, many of the signalling pathways associated with neuronal survival and axon regeneration are regulated by several classes of receptor tyrosine kinases (RTK) that respond to a variety of ligands. This paper highlights and summarises the most relevant recent findings pertinent to different classes of the RTK family of molecules, with a particular focus on elucidating their role in CNS axon regeneration.
APA, Harvard, Vancouver, ISO, and other styles
9

Chen, Stephanie Turner, Joel Kowalewski, and Anandasankar Ray. "Prolonged activation of carbon dioxide-sensitive neurons in mosquitoes." Interface Focus 11, no. 2 (February 12, 2021): 20200043. http://dx.doi.org/10.1098/rsfs.2020.0043.

Full text
Abstract:
Many insects can detect carbon dioxide (CO 2 ) plumes using a conserved receptor made up of members of the gustatory receptor (Gr) family Gr1, Gr2 and Gr3. Mosquitoes are attracted to host animals for blood meals using plumes of CO 2 in the exhaled breath using the receptor expressed in the A neuron of the capitate peg sensilla type on the maxillary palps. The receptor is known to also detect several other classes of odorants, including ones emitted from human skin. Here, we discover that a common skin odorant, butyric acid, can cause a phasic activation followed by an unusually prolonged tonic activity after the stimulus is over in the CO 2 neurons of mosquitoes. The effect is conserved in both Aedes aegypti and Anopheles gambiae mosquitoes. This raises a question about its role in a mosquito's preference for the skin odour of different individuals. Butyric acid belongs to a small number of odorants known to cause the prolonged activation of the CO 2 receptor. A chemical informatic analysis identifies a specific set of physico-chemical features that can be used in a machine learning predictive model for the prolonged activators. Interestingly, this set is different from physico-chemical features selected for activators or inhibitors, indicating that each has a distinct structural basis. The structural understanding opens up an opportunity to find novel ligands to manipulate the CO 2 receptor and mosquito behaviour.
APA, Harvard, Vancouver, ISO, and other styles
10

Miller, Lawrence G., Jack Heller, Monica Lumpkin, Cheryl L. Weill, David J. Greenblatt, and Richard I. Shader. "Augmentation of GABAA receptor function by chronic exposure to GABA-neutral and GABA-negative benzodiazepine ligands in cultured cortical neurons." Biochemical Pharmacology 40, no. 6 (September 1990): 1337–44. http://dx.doi.org/10.1016/0006-2952(90)90401-6.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Neurons. Ligands (Biochemistry)"

1

Zhang, Zhanping. "Neuron-ligand pathfinding studies by atomic force microscopy and other surface-sensitive methods." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 249 p, 2006. http://proquest.umi.com/pqdweb?did=1172109001&sid=2&Fmt=2&clientId=8331&RQT=309&VName=PQD.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Leng, Ying. "Neuron-ligand pathfinding on surfaces modified by laminin and laminin-derived peptides." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 78 p, 2006. http://proquest.umi.com/pqdweb?did=1203562381&sid=8&Fmt=2&clientId=8331&RQT=309&VName=PQD.

Full text
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Neurons. Ligands (Biochemistry)' for particular source types:
Journal articles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography