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Dissertations / Theses on the topic 'Neuropathology'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Spillantini, Maria Grazia. "Molecular neuropathology of Alzheimer's disease." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282037.

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2

Huseby, Carol. "Molecular Neuropathology in Alzheimer's Disease." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1543314678552794.

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3

Betts, Joanne. "The molecular neuropathology of mitochondrial disease." Thesis, University of Newcastle Upon Tyne, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421187.

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4

Tofaris, George Kynacov. "Molecular neuropathology of Lewy body disorders." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619824.

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5

Davis, Brittany. "Modelling the neuropathology of Ehmt1 haploinsufficiency." Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/73068/.

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EHMT1 is a gene that encodes an epigenetic regulator important for normal brain development. Disruption in EHMT1 is associated with a number of neurodevelopment and psychiatric conditions, like schizophrenia, Autism Spectrum Disorders, developmental delays and intellectual disabilities. In order to help elucidate the role of Ehmt1 in cortical development two models are examined: the differentiation of mouse pyramidal neurons lacking one copy of the gene and a forebrain-specific Ehmt1-haploinsufficient mouse model. Ehmt1+/- cells demonstrated changes in cell cycle, with significant differences

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6

Tabata, Rena Christina. "Neuropathology induced by sterol glucosides in mice." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/24178.

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Sterol glucosides are a family of compounds characterized by a carbohydrate unit bound to a tetracyclic carbon chain. They are found in high concentrations in cycad seeds which have been linked to the etiology of amyotrophic lateral scierosis-parkinsonism dementia complex (ALS-PDC). The neurotoxicities of the three main cycad sterol glucosides, campesterol β-D-glucoside, stigmasterol β-Dglucoside (SG), and β-sitosterol β-D-glucoside (BSSG) have been demonstrated previously in vitro. In the present study, we demonstrate that SC and BSSG exert neurotoxic effects in vivo. An outbred strain of mic

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7

Nagy, Zsuzsanna. "Aspects of the neuropathology of Alzheimer's disease." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240537.

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8

Bleshoy, Hans. "Neuropathology and sensitivity in the keratoconic cornea." Thesis, City University London, 1990. http://openaccess.city.ac.uk/7670/.

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Corneal touch threshold (CTT) was investigated by aesthesiometry in patients with keratoconusq with and without contact lens wear. Using a matching control group it was established that CTT was significantly higher for the central corneal position in keratoconus. No difference inCTT was found in four peripheral corneal positions in keratoconic and normal corneas. Central CTT correlated inversely with central corneal curvature and central corneal thickness. Central corneal curvature was the most significant single factor to correlate with central CTT and indicates that CTT increases (sensitivit

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9

Pitts, Georgia Eloise Rollo. "Neuropathology and cognitive dysfunction after early hypoglycaemia." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/10025822/.

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Hypoglycaemia is the most common metabolic problem in neonatal medicine, occurring during the first days of life and usually resolving within the same time frame. However, some neonates and infants experience severe and recurrent episodes of hypoglycaemia, the most common aetiologies being congenital hyperinsulinism (CHI) and ketotic hypoglycaemia (KH). Children with CHI are at risk of lasting brain injury, while children with KH are considered to be protected from adverse sequelae owing to the presence of ketone bodies during hypoglycaemia. This thesis investigated the neuropsychological and

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10

Henkes, Greta. "Neuropathologie primärer und sekundärer Mitochondriopathien im Rahmen entzündlicher Muskelerkrankungen." Doctoral thesis, Universitätsbibliothek Leipzig, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-71313.

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Idiopathische Myositiden stellen die größte Gruppe der erworbenen Myopathien im Erwachsenenalter dar. Die Pathogenese dieser Erkrankungen ist sehr heterogen und nicht in allen Einzelheiten geklärt. Das Auftreten von mitochondrialen Veränderungen und mtDNADeletionen in idiopathischen Myositiden und deren pathophysiologische Bedeutung ist in der Literatur ein kontrovers diskutiertes Thema. Nach der Präsentation des bekannten Wissens über diese Erkrankungen wird in vorliegender Arbeit dieses Thema anhand lichtmikroskopischer Methoden unter Anwendung histologischer Spezialmethoden an Muskelbiopsie

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11

Querol, Vilaseca Marta. "Novel digital neuropathology methods applied to neurodegenerative diseases." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/671999.

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Cada tres segons alguna persona al món desenvolupa demència. Les malalties neurodegeneratives, amb la malaltia d’Alzheimer (MA), la malaltia de Parkinson i la demència frontotemporal com les formes més predominants, són un grup de desordres que afecten a milions de persones arreu del món. La neuropatologia de mostres post-mortem humanes encara és necessària per esclarir els mecanismes subjacents alterats en les malalties neurodegeneratives. En aquesta tesis hem combinat immunoassaigs clàssics, tècniques de microscopia òptica i eines computacionals automatitzades per investigar la neuroinfla

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12

Moore, David Joseph. "Regional neuropathology and cognitive abilities in HIV infection /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2003. http://wwwlib.umi.com/cr/ucsd/fullcit?p3083453.

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13

Rahim, Rani Sadia. "Neuropathology in a Mouse Model of Zellweger Syndrome." Thesis, Griffith University, 2017. http://hdl.handle.net/10072/367161.

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Zellweger syndrome (ZS) is a congenital peroxisome biogenesis disorder which has both features of neurodegeneration and defective neurodevelopment. ZS patients exhibit significant changes to brain morphology, prominent cell migration defects, and neurodegeneration; defects leading to severe motor and cognitive dysfunction. ZS is caused by mutation in PEX genes which encode proteins necessary for peroxisomes biogenesis. Loss of peroxisome biogenesis results in the deficiency of various peroxisomal metabolic functions, such as β-oxidation of very-long-chain-fatty acids, and biosynthesis of essen

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14

Highley, J. Robin. "The asymmetry, interhemispheric connectivity, and gyral structure of the brain in schizophrenia : a post mortem study." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244561.

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15

Cotter, David Richard. "Abnormal brain development in schizophrenia : an investigation of potental mechanisms." Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299927.

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16

Arotcarena, Marie-Laure. "Approches multifactorielles et translationnelles dans la modélisation des synucléinopathies : implications mécanistiques et thérapeutiques." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0164/document.

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Mon projet de thèse a été dédié à l’étude des synucléinopathies. Ces maladies neurodégénératives sont caractérisées par la présence d’inclusions intracytoplasmiques positives pour l’alpha-synucléine et contenues dans les neurones pour la maladie de Parkinson (i.e. les corps de Lewy) ou dans les oligodendrocytes pour l’atrophie multisystématisée (i.e. les inclusions cytoplasmiques oligodendrogliales). L’objectif de mon travail de thèse fut de proposer une approche multifactorielle et translationnelle en développant les aspects de modélisation, de mécanistiques et de thérapeutiques associées aux

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17

Schumann, Cynthia Mills. "Neuropathology of the amygdaloid complex in autism spectrum disorders /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2005. http://uclibs.org/PID/11984.

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18

Golder, Mark Stephen. "An investigation into the neuropathology of uncomplicated diverticular disease." Thesis, Queen Mary, University of London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497886.

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19

Liu, Jia [Verfasser], and Adrian [Akademischer Betreuer] Danek. "Neuropathology of Chorea-acanthocytosis / Jia Liu. Betreuer: Adrian Danek." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/1098130839/34.

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20

Dickson, Jonathan Mark. "The neuropathology of Parkinson's disease : cognitive and motor consequences." Thesis, University of Sheffield, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340171.

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21

Van, Paesschen Wim. "Quantitative MRI and hippocampal neuropathology of temporal lobe epilepsy." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265249.

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22

McKavanagh, Rebecca. "The neuropathology of the social cognitive network in autism." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:e189c42c-7c87-470d-ab8f-c6b66a430f5e.

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Potential differences in developmental trajectory were investigated in autism at both the macro- and micro-scopic scale, using regional volumetric measurements from in-vivo scans and measurements of minicolumnar organisation of the cortex in post-mortem tissue. In addition, a study was carried out to investigate the sensitivity of measures of cortical diffusion to cortical architecture. Three key regions of interest were studied throughout this thesis, orbital frontal cortex (BA11), primary auditory cortex (BA41) and part of the inferior parietal lobe (BA40). Subjects with ASD showed increases

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23

Hahn, Caroline Nora. "Central neuropathology and clinicopathological correlates in equine grass sickness." Thesis, University of Edinburgh, 2000. http://hdl.handle.net/1842/30244.

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Equine Grass Sickness has traditionally been known as a dysautonomia, principally affecting parasympathetic neurons in the enteric nervous system. Studies of central neuropathology have been cursory and conflicting, examining different and occasionally poorly defined central structures in variable numbers of cases and control animals. There was no agreement on the association or severity of clinical signs with the severity of central pathological changes. This study accurately describes the distribution of pathology in the brain of EGS cases. Chromatolytic neurons have a highly specific distri

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24

Mudariki, Temba. "Diagnostic neuropathology of brain tumours using biophotonics and spectrometry." Thesis, University of Central Lancashire, 2016. http://clok.uclan.ac.uk/16665/.

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Classification of tumours such as gliomas, which are on a continuous spectrum of histology and malignancy into distinct categories is still a challenge using histopathology. There has been significant advances in the techniques used to fight cancer in the past two decades. A number of studies have looked at different approaches to improve the accuracy in diagnosis using histopathology. This study evaluated a number of techniques to compliment histopathology. One study looked at vibrational spectroscopy, Raman and attenuated total reflection-fourier transform infrared (ATR-FTIR) looking at brai

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25

Ordway, Gregory A. "Neuropathology of Central Norepinephrine in Psychiatric Disorders: Postmortem Research." Digital Commons @ East Tennessee State University, 2007. https://dc.etsu.edu/etsu-works/8613.

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The postmortem human brain as a tool to study central nervous system disease Abnormalities in noradrenergic transmission are likely to play a role in behavioral expressions of a number of psychiatric and neurological disorders. The extent to which these abnormalities are pathognomonic, or even principal pathological features contributing to the illness, remains debatable. Interest in the potential for pathological abnormalities in central norepinephrine in central nervous system (CNS) disorders derives from the three general observations: (1) disruption of behaviors known to be heavily influen

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26

Lanoue, Amelie Cecile. "Neuropathology in the dorsolateral prefrontal cortex in Parkinson's disease." Thesis, Boston University, 2013. https://hdl.handle.net/2144/11112.

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Thesis (Ph.D.)--Boston University<br>Degeneration of dopaminergic neurons in the substantia nigra pars compacta is the hallmark neuropathological feature of Parkinson's disease (PD). Multiple lines of evidence from anatomical and imaging studies indicate that cell loss or cell dysfunction also occur in other brain regions. The dorsolateral prefrontal cortex (DLPFC) is a region of interest because it could be implicated in both cognitive and motor symptoms of PD. However, studies in this brain region are limited and the extent of pathology is unclear. Work in this thesis was aimed at identifyin

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27

Bristow, Greg. "Investigations of the potential schizophrenia susceptibility gene Kinase Interacting with Stathmin (KIS)." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:432fc195-815c-4bc6-945f-c2b59aa3538c.

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Single nucleotide polymorphisms (SNPs) within the gene encoding the serine threonine kinase KIS (Kinase Interacting with Stathmin, also known as UHMK1) have recently been associated with schizophrenia. However, little is known about the neurobiology of KIS or the mechanisms through which disease-associated SNPs may increase susceptibility to schizophrenia. The studies presented in this thesis focus on the distribution of KIS and its mRNA, address the mechanisms through which KIS may confer susceptibility to schizophrenia, and investigate the physiological role(s) of KIS in the brain using two

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28

Mochida, Rumi. "Survey of Neuropathology in Obese and Diabetic ZDSD Rat Brain." Available to subscribers only, 2009. http://proquest.umi.com/pqdweb?did=1966536741&sid=1&Fmt=2&clientId=1509&RQT=309&VName=PQD.

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29

Thompson, Lachlan H. (Lachlan Heath) 1974. "Receptor and neurochemical changes in models of Alzheimer-like neuropathology." Monash University, Dept. of Pharmacology, 2002. http://arrow.monash.edu.au/hdl/1959.1/7931.

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30

Thomas, Alan J. "A study of vascular neuropathology in late-life major depression." Thesis, University of Newcastle Upon Tyne, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394641.

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31

West, Daniel Alexander. "The development of experimental models for NMR studies of neuropathology." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406284.

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32

Genoud, Sian. "The role of biometals in the neuropathology of Parkinson’s disease." Thesis, The University of Sydney, 2020. https://hdl.handle.net/2123/22449.

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Parkinson’s disease (PD) is a neurodegenerative disorder characterised by the progressive loss of dopaminergic neurons, particularly in the ventral substantia nigra. Growing evidence implicates biometal dyshomeostasis and subsequent metal-catalysed neurotoxicity in vulnerable regions of the PD brain. Through meta-analysis, I confirm previously reported reductions in Cu, and elevations in Fe specifically in the substantia nigra of the PD brain, which are not reflected by similar changes in biofluid tissues. These changes are further restricted to the soluble fraction of nigral tissue – suggesti

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33

Milosevic, Javorina, Sigrid C. Schwarz, Vera Ogunlade, Anne K. Meyer, Alexander Storch, and Johannes Schwarz. "Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiation." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-184308.

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Despite a comprehensive mapping of the Parkinson's disease (PD)-related mRNA and protein leucine-rich repeat kinase 2 (LRRK2) in the mammalian brain, its physiological function in healthy individuals remains enigmatic. Based on its structural features and kinase properties, LRRK2 may interact with other proteins involved in signalling pathways. Here, we show a widespread LRRK2 mRNA and/or protein expression in expanded or differentiated human mesencephalic neural progenitor cells (hmNPCs) and in post-mortem substantia nigra PD patients. Using small interfering RNA duplexes targeting LRRK2 in h

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34

Cullen, Thomas. "The neuropathology of the prefrontal cortex and mediodorsal thalamus in schizophrenia." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427875.

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35

Kam, Korey. "On neuronal hyperexcitability in a mouse model of B-amyloid neuropathology." Thesis, New York University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10192483.

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<p> At present, Alzheimer’s disease (AD) is an incurable neurodegenerative dementia. It has been suggested that neuronal hyperexcitability contributes to AD, so we asked how hyperexcitability develops in a common mouse model of β-amyloid neuropathology - Tg2576 mice. These mice overexpress the Swedish familial mutation of human-amyloid precursor protein (hAPP). Using video-EEG recordings, we found synchronized, large amplitude potentials resembling interictal spikes (IIS) in epilepsy at just 5 weeks of age, long before memory impairments or β-amyloid deposition. Seizures were u

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36

Manner, Cathyryne Kapiolani. "The consequences of CAT2 arginine transporter ablation in cancer and neuropathology /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2003. http://wwwlib.umi.com/cr/ucsd/fullcit?p3091320.

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37

Heath, P. D. "Cortical somatosensory evoked potentials in parkinsonism." Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233645.

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38

Jamieson, Elizabeth Ann. "Distribution and regulation of proteins related to neuronal degeneration." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284705.

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39

Paine, Simon Marcus Liddell. "Conditional proteasome gene deletion : molecular neuropathology and the pathogenesis of Parkinson’s disease." Thesis, University of Nottingham, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.580175.

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Parkinson's disease is an archetypal sporadic neurodegenerative disease: it is age-related and results in region-specific neurodegeneration with intracellular inclusions in many of the remaining neurones. Despite three decades of intense study, disease modifying therapies remain beyond the horizon, reflecting our understanding of the pathological process and the intrinsic challenges that the degenerative diseases of the brain present. Dysfunction in a number of cellular systems has been implicated in the development of Parkinson's disease. Protein homeostasis in terminally differentiated neuro

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40

Brown, Nolan J. "Localization of hemoglobin in MS cortex and its relevance to MS neuropathology." Kent State University Honors College / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1399400834.

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41

Turner, Gareth David Huw. "An immunohistochemical study of the pathology of malaria." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318458.

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42

Pearce, Janice. "The trafficking of apolipoprotein E and its effect upon tau phosphorylation." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325158.

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43

Österman, Hanna. "Olfactory performance and neuropathology in the Tg6799 strain of Alzheimer’s disease model mice." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-56816.

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The present study evaluated olfactory and cognitive abilities of the Tg6799 (also called 5xFAD) strain of Alzheimer’s disease (AD) model mice of two different age groups (2-3 and 8-10 months of age), and one group of healthy control mice (9-10 months). Employment of an operant conditioning paradigm using an automated olfactometer, an olfactory habituation/dishabituation test and a spatial learning test with non olfactory cues resulted in data showing that the 5xFAD mice develop olfactory impairments already at 2-3 months of age. The impairments consisted in a robust impairment in olfactory sen

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44

Bayram-Weston, Zubeyde. "Longitudinal characterisation of neuropathology in transgenic and knock-in Huntington's disease mouse lines." Thesis, Cardiff University, 2011. http://orca.cf.ac.uk/14609/.

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The work presented in this thesis consists of 4 manuscripts, focussed on characterising the distribution of mutant huntingtin protein in transgenic and knock-in mouse models of Huntington’s disease. The mouse lines showed a different expression level of mutant huntingtin across the different time points. In the R6/1 mice, the inclusions were present and widespread from 3.5 weeks of age. In the YAC128 mice, inclusions were not present until 15 months of age, but then developed rapidly throughout the brain. In the HdhQ92 and HdhQ150 mice, intra nuclear inclusions (NIIs) were apparent at 10 and 5

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45

Purushothuman, Sivaraman. "The neuropathology of age-related degenerations: Cause and protection assessed in rodent models." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/11488.

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Neurodegenerative diseases such as age-related dementia (ARD; Alzheimer’s disease) and Parkinson’s disease are a consequence of age-related pathological changes in the central nervous system (CNS). There is a growing body of evidence that ARD is a vascular dementia, caused by micro-haemorrhages from cerebral capillaries. Oxidative stress and mitochondrial dysfunction caused by haemorrhage are then thought to cause the features of the demented brain which Alzheimer described (senile plaques, neurofibrillary tangles and inflammation) and the cell death, synaptic loss and the formation of abnorma

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46

BOI, LAURA. "Neuroinflammation in Parkinson’s Disease: role in neuropathology and L-DOPA-induced motor complications." Doctoral thesis, Università degli Studi di Cagliari, 2020. http://hdl.handle.net/11584/284805.

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Parkinson Disease (PD) is a neurodegenerative disorder characterized by the progressive dopaminergic loss in the Substantia Nigra (SN) and the presence of intracellular Lewy Bodies (LB) containing deposits of the protein α-synuclein (α-syn). Several studies identified the neuroinflammatory processes as important factors in the neuropathology of PD, involving mainly microglia cells. Indeed, in PD microglia lose their ability to autoregulate, sustaining a chronic pro-inflammatory environment in dopaminergic areas which exacerbates the neurodegenerative process. Moreover, recent pre-clinical stud

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47

Milosevic, Javorina, Sigrid C. Schwarz, Vera Ogunlade, Anne K. Meyer, Alexander Storch, and Johannes Schwarz. "Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiation." Biomed Central, 2009. https://tud.qucosa.de/id/qucosa%3A28998.

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Despite a comprehensive mapping of the Parkinson's disease (PD)-related mRNA and protein leucine-rich repeat kinase 2 (LRRK2) in the mammalian brain, its physiological function in healthy individuals remains enigmatic. Based on its structural features and kinase properties, LRRK2 may interact with other proteins involved in signalling pathways. Here, we show a widespread LRRK2 mRNA and/or protein expression in expanded or differentiated human mesencephalic neural progenitor cells (hmNPCs) and in post-mortem substantia nigra PD patients. Using small interfering RNA duplexes targeting LRRK2 in h

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48

TAKAHASHI, AKIRA, YOSHIO HASHIZUME, and NOBUKO UJIHIRA. "A CLINICO-NEUROPATHOLOGICAL STUDY ON BRAIN DEATH." Nagoya University School of Medicine, 1993. http://hdl.handle.net/2237/15930.

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49

Sloan, Maximilian. "The behavioural and molecular characterisation of a novel LRRK2 BAC transgenic rat model of Parkinson's disease." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:c2058b71-df43-47cd-a794-13184bacf313.

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50

IRITANI, SHUJI. "What Happens in the Brain of Schizophrenia Patients?: An Investigation from the Viewpoint of Neuropathology." Nagoya University School of Medicine, 2013. http://hdl.handle.net/2237/17597.

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