Relevant bibliographies by topics / Neuropathy target esterase

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  2. Dissertations / Theses
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Academic literature on the topic 'Neuropathy target esterase'

Author: Grafiati
Published: 7 July 2024
Last updated: 31 July 2025

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Journal articles on the topic "Neuropathy target esterase"

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GLYNN, Paul. "Neuropathy target esterase." Biochemical Journal 344, no. 3 (1999): 625–31. http://dx.doi.org/10.1042/bj3440625.

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Neuropathy target esterase (NTE) is an integral membrane protein present in all neurons and in some non-neural-cell types of vertebrates. Recent data indicate that NTE is involved in a cell-signalling pathway controlling interactions between neurons and accessory glial cells in the developing nervous system. NTE has serine esterase activity and efficiently catalyses the hydrolysis of phenyl valerate (PV) in vitro, but its physiological substrate is unknown. By sequence analysis NTE has been found to be related neither to the major serine esterase family, which includes acetylcholinesterase, no
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GLYNN, Paul. "Neuropathy target esterase." Biochemical Journal 344, no. 3 (1999): 625. http://dx.doi.org/10.1042/0264-6021:3440625.

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Hou, Wei-Yuan, Ding-Xin Long, and Yi-Jun Wu. "Effect of Inhibition of Neuropathy Target Esterase in Mouse Nervous Tissues In Vitro on Phosphatidylcholine and Lysophosphatidylcholine Homeostasis." International Journal of Toxicology 28, no. 5 (2009): 417–24. http://dx.doi.org/10.1177/1091581809340704.

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Neuropathy target esterase has been shown to be a lysophospholipase in mouse. The authors investigate the effect of neuropathy target esterase inhibition in mouse nervous tissues in vitro on the homeostasis of phosphatidylcholine and lysophosphatidylcholine by treating the homogenates with tri-ortho-cresyl phosphate, paraoxon, paraoxon plus mipafox, and phenylmethylsulfonyl fluoride. The activity of neuropathy target esterase is significantly inhibited by phenylmethylsulfonyl fluoride and paraoxon plus mipafox but not by paraoxon alone. Tri-ortho-cresyl phosphate slightly but significantly inh
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Glynn, Paul. "Axonal Degeneration and Neuropathy Target Esterase." Archives of Industrial Hygiene and Toxicology 58, no. 3 (2007): 355–58. http://dx.doi.org/10.2478/v10004-007-0029-z.

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Axonal Degeneration and Neuropathy Target EsteraseThis brief review summarises recent observations which suggest a possible mechanism for organophosphate-induced delayed neuropathy (OPIDN). Neuropathy target esterase (NTE) has been shown to deacylate endoplasmic reticulum (ER) membrane phosphatidylcholine (PtdCho). Raised levels of PtdCho are present in the brains of swiss cheese/NTE mutant Drosophila together with abnormal membrane structures, axonal and dendritic degeneration and neural cell loss. Similar vacuolated pathology is found in the brains of mice with brain-specific deletion of the
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Lush, Michael, David Read, and Paul Glynn. "Molecular cloning of neuropathy target esterase." Toxicology Letters 88 (October 1996): 27. http://dx.doi.org/10.1016/s0378-4274(96)80098-1.

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Glynn, Paul. "Neurodegeneration involving neuropathy target esterase (NTE)." Toxicology Letters 164 (September 2006): S9. http://dx.doi.org/10.1016/j.toxlet.2006.06.023.

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Glynn, Paul. "Neuropathy target esterase and phospholipid deacylation." Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1736, no. 2 (2005): 87–93. http://dx.doi.org/10.1016/j.bbalip.2005.08.002.

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Bertoncin, Daniela, Alessandra Russolo, Stefano Caroldi, and Marcello Lotti. "Neuropathy Target Esterase in Human Lymphocytes." Archives of Environmental Health: An International Journal 40, no. 3 (1985): 139–44. http://dx.doi.org/10.1080/00039896.1985.10545905.

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Thomas, Thomas C., András Székács, Bruce D. Hammock, Barry W. Wilson, and Mark G. McNamee. "Affinity chromatography of neuropathy target esterase." Chemico-Biological Interactions 87, no. 1-3 (1993): 347–60. http://dx.doi.org/10.1016/0009-2797(93)90063-5.

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Seifert, Josef. "A Tentative Mechanism of Solubilization of Neuropathy Target Esterase from Chicken Embryo Brain by Phospholipase A2." Scientific World JOURNAL 8 (2008): 346–49. http://dx.doi.org/10.1100/tsw.2008.51.

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The neuropathy target esterase is a membrane-bound enzyme linked to organophosphate-induced distal neuropathy. Here we report a tentative mechanism of its solubilization from chicken embryo brains by using phospholipase A2. The enzyme was released from brain membranes after degradation of their structural phospholipids initiated by phospholipase A2. L-α-lysophosphatidylcholine, tested as a representative product of phospholipid hydrolysis, was identified as a new efficient detergent for solubilization of the neuropathy target esterase.
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Dissertations / Theses on the topic "Neuropathy target esterase"

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Lush, Michael John. "Molecular cloning of neuropathy target esterase." Thesis, University of Leicester, 1998. http://hdl.handle.net/2381/29627.

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A single ingestion of certain organophosphorus esters (OPs) can cause a syndrome known as Organophosphate Induced Delayed Polyneuropathy (OPIDP), a paralysing neuropathy with degeneration of long axons, developing after a latent period of approximately one to three weeks. The primary target of these OPs has been shown to be a 155kDa neural protein designated Neuropathy Target Esterase (NTE), and the toxic effects apparently due to the covalent inhibition and subsequent secondary modification of this protein. Recently NTE has been purified to apparent homogeneity using a novel biotinylated OP a
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Rezaie-Moazen, Nima. "Characterisation of neuropathy target esterase in mammalian cells." Thesis, University of Leicester, 2005. http://hdl.handle.net/2381/30775.

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The present study found that NTE's catalytic activity is not regulated by cAMP. Purification of the R domain could not be achieved as the recombinant polypeptide is essentially insoluble and consequently, direct cAMP binding could not be attempted. The reduction of NTE activity in HeLa cells caused inhibition of GroPCho production without altering PtdCho levels. Conversely, the inducible overexpression of NTE in a stable HeLa cell line resulted in increased GroPCho production also without altering PtdCho levels. Treatment of HeLa cells with ether-linked lipids caused an apparent inhibition of
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Zaccheo, Oliver. "Analysis of the yeast homologue of neuropathy target esterase." Thesis, University of Leicester, 2003. http://hdl.handle.net/2381/30772.

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Neuropathy Target Esterase (NTE) is an essential protein implicated in mammalian neural development and was first identified as the target for those organophosphates (OPs) that cause a delayed neuropathy. NTE has esterase activity, allowing it to hydrolyse the artificial substrate phenyl valerate in vitro: this can be followed in a simple assay. OPs inhibit this activity by reacting with the essential active site serine of NTE. Recent evidence suggests the physiological substrate of NTE to be a lysophospholipid. Previous work has shown that a region of 489 amino acids towards the C-terminal of
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Atkins, Jane. "Biochemical characterisation of the catalytic domain of neuropathy target esterase." Thesis, University of Leicester, 2000. http://hdl.handle.net/2381/29643.

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Neuropathy target esterase (NTE) is an integral membrane protein found predominantly in neurones. Covalent modification of NTE's active site serine, by certain organophosphates (OPs), results in a neurodegenerative syndrome. NTE's physiological substrate is unknown and its catalytic activity does not seem to be vital in the adult animal. The enzyme domain of human NTE (residues 727-1216), called NEST, was expressed in E. coli and reacted with a carboxyl ester substrate and OP inhibitors the same as native NTE. During purification catalytic activity was lost, but was restored by reconstitution
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Meredith, C. "Biochemical studies on neuropathy target esterase and its role in the initiation of delayed neuropathy by some organophosphorus esters." Thesis, University of Cambridge, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373779.

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Emerick, Guilherme Luz [UNESP]. "Avaliação de neurotoxicidade de formas enantioméricas de praguicidas organifosforados: estudos in vitro, in vivo e de neuroproteção." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/106391.

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Made available in DSpace on 2014-06-11T19:35:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-03-02Bitstream added on 2014-06-13T20:07:10Z : No. of bitstreams: 1 emerick_gl_dr_arafcf.pdf: 6421431 bytes, checksum: 0afb014cdc72c52072c05813f940629d (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Universidade Estadual Paulista (UNESP)<br>Clinicamente, os sintomas da intoxicação por organofosforados (OPs) são divididos em quatro categorias: síndrome colinérgica, síndrome intermediária, transtornos neuropsiquiátricos crônicos induzidos por OPs e neuropatia retard
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Emerick, Guilherme Luz. "Avaliação de neurotoxicidade de formas enantioméricas de praguicidas organifosforados : estudos in vitro, in vivo e de neuroproteção /." Araraquara : [s.n.], 2012. http://hdl.handle.net/11449/106391.

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Orientador: Georgino Honorato de Oliveira<br>Coorientador: Regina Vincenzi Oliveira<br>Banca: Maria Palmira Daflon Gremião<br>Banca: Antonio Cardozo dos Santos<br>Banca: Rosângela Gonçalves Peccinini<br>Banca: Silvana Aparecida Calafatti<br>Resumo: Clinicamente, os sintomas da intoxicação por organofosforados (OPs) são divididos em quatro categorias: síndrome colinérgica, síndrome intermediária, transtornos neuropsiquiátricos crônicos induzidos por OPs e neuropatia retardada induzida por OPs (NRIOP). Há estudos que comprovam a ocorrência de casos de NRIOP em seres humanos após intoxicação por
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Mercé, Théo. "High-throughput zebrafish larval locomotion assays of neuronal and muscular functions : Application to organophosphorus toxicity and antid." Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0011.

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La prévalence croissante des contaminants chimiques pose d'importants problèmes en matière de santé publique, nécessitant des méthodologies efficaces pour l'évaluation des risques toxicologiques. Un travail initial a été réalisé pour optimiser une nouvelle approche méthodologique (NAM) utilisant des éleuthéroembryons de poisson-zèbre, appelée electric field pulse motor response test (EFPMRT). La méthode vise à effectuer un criblage à haut débit des molécules chimiques induisant des défauts des capacités motrices et du contrôle postural. La robustesse, la reproductibilité, la productivité et la
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Books on the topic "Neuropathy target esterase"

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Ehrich, Marion. Relationship of neuropathy target esterase inhibition to neuropathology and ataxia in hens given organophosphorus esters. Environmental Protection Agency], 1993.

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Book chapters on the topic "Neuropathy target esterase"

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Wu, Yi-Jun, and Ping-An Chang. "Molecular Toxicology of Neuropathy Target Esterase." In Anticholinesterase Pesticides. John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9780470640500.ch9.

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Lush, Michael, David Read, and Paul Glynn. "Molecular Cloning of Neuropathy Target Esterase." In Archives of Toxicology. Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60682-3_39.

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Lotti, Marcello. "Neuropathy Target Esterase in Blood Lymphocytes." In Biological Monitoring for Pesticide Exposure. American Chemical Society, 1988. http://dx.doi.org/10.1021/bk-1988-0382.ch009.

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Glynn, Paul. "Neuropathy Target Esterase (NTE): Molecular Characterisation and Cellular Localisation." In Archives of Toxicology. Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60682-3_30.

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Mackay, C. E., B. D. Hammock, and B. W. Wilson. "Identification of a 155 kDa Fraction that Possesses Neuropathy Target Esterase Activity." In Enzymes of the Cholinesterase Family. Springer US, 1995. http://dx.doi.org/10.1007/978-1-4899-1051-6_74.

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Johnson, Martin K., and Paul Glynn. "Neuropathy Target Esterase." In Handbook of Pesticide Toxicology. Elsevier, 2001. http://dx.doi.org/10.1016/b978-012426260-7.50050-1.

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Wijeyesakere, Sanjeeva J., and Rudy J. Richardson. "Neuropathy Target Esterase." In Hayes' Handbook of Pesticide Toxicology. Elsevier, 2010. http://dx.doi.org/10.1016/b978-0-12-374367-1.00067-7.

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"NTE (neuropathy target esterase)." In Encyclopedia of Genetics, Genomics, Proteomics and Informatics. Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6754-9_11590.

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Srivastava, Devesh, Neeraj Kohli, Rudy J., Robert M., and Ilsoon Lee. "Neuropathy Target Esterase Biosensor." In Intelligent and Biosensors. InTech, 2010. http://dx.doi.org/10.5772/7156.

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Johnson, Martin K. "Molecular events in delayed neuropathy: experimental aspects of neuropathy target esterase." In Clinical and Experimental Toxicology of Organophosphates and Carbamates. Elsevier, 1992. http://dx.doi.org/10.1016/b978-0-7506-0271-6.50016-4.

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