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Journal articles on the topic 'Neuropsychiatric fluctuations'

Author: Grafiati

Published: 7 July 2024

Last updated: 31 July 2025

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1

Magalhães, Andreia D., Deborah Amstutz, Katrin Petermann, et al. "Subthalamic stimulation has acute psychotropic effects and improves neuropsychiatric fluctuations in Parkinson’s disease." BMJ Neurology Open 6, no. 1 (2024): e000524. http://dx.doi.org/10.1136/bmjno-2023-000524.

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BackgroundSubthalamic nucleus deep brain stimulation (STN-DBS) is a well-established treatment for motor complications in Parkinson’s disease (PD). However, its effects on neuropsychiatric symptoms remain disputed. The aim of this study was to evaluate the effects of STN-DBS on neuropsychiatric symptoms in PD.MethodsWe retrospectively assessed 26 patients with PD who underwent a preoperative levodopa challenge and postoperative levodopa and stimulation challenges 1 year after STN-DBS. Based on the Neuropsychiatric Fluctuations Scale, Neuropsychiatric State Scores and Neuropsychiatric Fluctuati

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Fox, Susan H., Naomi Visanji, Gaby Reyes, et al. "Neuropsychiatric Behaviors in the MPTP Marmoset Model of Parkinson’s Disease." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 37, no. 1 (2010): 86–95. http://dx.doi.org/10.1017/s0317167100009707.

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Objectives:Neuropsychiatric symptoms are increasingly recognised as a significant problem in patients with Parkinson's disease (PD). These symptoms may be due to ‘sensitisation’ following repeated levodopa treatment or a direct effect of dopamine on the disease state. The levodopa-treated MPTP-lesioned marmoset was used as a model of neuropsychiatric symptoms in PD patients. Here we compare the time course of levodopa-induced motor fluctuations and neuropsychiatric-like behaviors to determine the relationship between duration of treatment and onset of symptoms.Methods:Marmosets were administer

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Abbes, Marie, Eugénie Lhommée, Stéphane Thobois, et al. "Subthalamic stimulation and neuropsychiatric symptoms in Parkinson’s disease: results from a long-term follow-up cohort study." Journal of Neurology, Neurosurgery & Psychiatry 89, no. 8 (2018): 836–43. http://dx.doi.org/10.1136/jnnp-2017-316373.

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BackgroundReports on behavioural outcomes after subthalamic nucleus deep brain stimulation in Parkinson’s disease are controversial and limited to short-term data. Long-term observation in a large cohort allows a better counselling and management.MethodsTo determine whether a long-term treatment with subthalamic stimulation induces or reduces impulse control behaviours, neuropsychiatric fluctuations and apathy, 69 patients treated with subthalamic stimulation are prospectively and retrospectively assessed using Ardouin Scale of Behavior in Parkinson’s Disease before and after 3–10 years of sti

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Schmitt, Emmanuelle, Paul Krack, Anna Castrioto, et al. "The Neuropsychiatric Fluctuations Scale for Parkinson's Disease: A Pilot Study." Movement Disorders Clinical Practice 5, no. 3 (2018): 265–72. http://dx.doi.org/10.1002/mdc3.12607.

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Matar, Elie, Simon R. White, John-Paul Taylor, et al. "Progression of Clinical Features in Lewy Body Dementia Can Be Detected Over 6 Months." Neurology 97, no. 10 (2021): e1031-e1040. http://dx.doi.org/10.1212/wnl.0000000000012450.

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ObjectiveThis study aimed to quantify the trajectory and magnitude of change of the key clinical features and corresponding symptom domains of dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD), including global cognition, parkinsonism, recurrent visual hallucinations, cognitive fluctuations, and sleep disturbance.MethodsOne hundred sixteen patients with Lewy body dementia (DLB = 72, PDD = 44) underwent assessment at baseline and 3 and 6 months as part of a prospective multicenter randomized controlled trial. Linear mixed models were constructed for core outcome measures usin

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Zimmer, Eduardo R., Maxime J. Parent, Antoine Leuzy, et al. "Imaging in Vivo Glutamate Fluctuations with [11C]ABP688: A GLT-1 Challenge with Ceftriaxone." Journal of Cerebral Blood Flow & Metabolism 35, no. 7 (2015): 1169–74. http://dx.doi.org/10.1038/jcbfm.2015.35.

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Molecular imaging offers unprecedented opportunities for investigating dynamic changes underlying neuropsychiatric conditions. Here, we evaluated whether [11C]ABP688, a positron emission tomography (PET) ligand that binds to the allosteric site of the metabotropic glutamate receptor type 5 (mGluR5), is sensitive to glutamate fluctuations after a pharmacological challenge. For this, we used ceftriaxone (CEF) administration in rats, an activator of the GLT-1 transporter (EAAT2), which is known to decrease extracellular levels of glutamate. MicroPET [11C]ABP688 dynamic acquisitions were conducted

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Donaghy, Paul C., John-Paul Taylor, John T. O'Brien, et al. "Neuropsychiatric symptoms and cognitive profile in mild cognitive impairment with Lewy bodies." Psychological Medicine 48, no. 14 (2018): 2384–90. http://dx.doi.org/10.1017/s0033291717003956.

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AbstractBackgroundThe accurate clinical characterisation of mild cognitive impairment (MCI) is becoming increasingly important. The aim of this study was to compare the neuropsychiatric symptoms and cognitive profile of MCI with Lewy bodies (MCI-LB) with Alzheimer's disease MCI (MCI-AD).MethodsParticipants were ⩾60 years old with MCI. Each had a thorough clinical and neuropsychological assessment and 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane single photon emission computed tomography FP-CIT SPECT). MCI-LB was diagnosed if two or more diagnostic features of dementia with L

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Vilanova, Juliana de Castro, Antonione Santos Bezerra Pinto, and Giuliano da Paz Oliveira. "Brás Cubas, Quincas Borba, and Rubião: portraits of neuropsychiatry in the novels of Machado de Assis." Arquivos de Neuro-Psiquiatria 83, no. 04 (2025): 001–5. https://doi.org/10.1055/s-0045-1806828.

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AbstractThe intersection of literature and neuroscience provides a fascinating way to explore human behavior through fictional narratives. Brazilian literature, particularly the work of Machado de Assis, excels in portraying characters with neuropsychiatric conditions. This work aims to establish connections between the fictional representations of human behavior in Machado's classic works and neurological conditions described by contemporary neuroscience. In The Posthumous Memoirs of Brás Cubas and Quincas Borba, Machado's characters exhibit behaviors that align with modern neurological diagn

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Krouse, Adam, Huihua Li, Joseph A. Krenzer, and William Nicholas Rose. "Plasmapheresis, Rituximab, and Ceftriaxone Provided Lasting Improvement for a 27-Year-Old Adult Male with Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS)." Case Reports in Psychiatry 2021 (November 2, 2021): 1–4. http://dx.doi.org/10.1155/2021/8697902.

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Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) is a specific autoimmune response to group-A streptococcal (GAS) infections in children and adolescents with a sudden onset of neuropsychiatric disorders including obsessive-compulsive disorder (OCD) or tic-like symptoms. We present a case report of a 27-year-old male patient who had lasting improvement with plasmapheresis, rituximab, and ceftriaxone. Our patient first developed sudden psychosis and confusion after GAS infections at age 17. He had elevated anti-streptolysin O (ASO) titers, negativ

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Infante, Roberto, Emmanuelle Schmitt, Sara Meoni, et al. "Effects of subthalamic deep brain stimulation on neuropsychiatric fluctuations in patients with Parkinson's disease (psychostim study)." Journal of the Neurological Sciences 429 (October 2021): 117639. http://dx.doi.org/10.1016/j.jns.2021.117639.

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11

Oliveira, S. G., S. M. Pereira, and J. Mendes. "Dementia in Parkinson's disease: Case report." European Psychiatry 26, S2 (2011): 846. http://dx.doi.org/10.1016/s0924-9338(11)72551-2.

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IntroductionParkinson's disease (PD) dementia is a rapidly growing global health problem. Dementia in PD is often accompanied with neuropsychiatric manifestations, such as depression, insomnia, visual hallucinations and psychomotor agitation, which need psychiatric attention.ObjectivesThe authors’ aim is to report a case of a 76-year-old female suffering from PD who was admitted to the psychiatric yard exhibiting neuropsychiatric symptoms. A literature's review about PD dementia was also made.Case reportPatient had one psychiatric hospitalization at age 41, due to depressive symptoms. PD diagn

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Yılmaz, Rezzak, Çağlar Sarılar, and Cenk Akbostancı. "Continuous infusion of apomorphine in a series of thirty patients with parkinson's disease." NATIONAL JOURNAL OF NEUROLOGY, no. 3 (January 9, 2019): 43–47. http://dx.doi.org/10.28942/nnj.v1i3.181.

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Apomorphine is a dopamine agonist primarily used for the treatment of motor fluctuations and severe dyskinesias in late – stage Parkinson’s Disease. We retrospectively studied medical records of 30 patients who were on continuous apomorphine infusion treatment. They were evaluated for their disease characteristics, satisfaction for the therapy and adverse events. Results showed that 17 patients were satisfied with the therapy. The main reason of cessation of therapy (15 patients) was subthalamic nucleus deep brain stimulation. Arrythmia and subcutaneous nodules were relatively rare (3 patients

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Yılmaz, Rezzak, A. Çağlar Sarılar, and M. Cenk Akbostancı. "CONTINUOUS INFUSION OF APOMORPHINE IN A SERIES OF THIRTY PATIENTS WITH PARKINSON'S DISEASE." National Journal of Neurology 1, no. 03 (2013): 55–59. http://dx.doi.org/10.61788/njn.v1i13.08.

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Apomorphine is a dopamine agonist primarily used for the treatment of motor fluctuations and severe dyskinesias in late – stage Parkinson’s Disease. We retrospectively studied medical records of 30 patients who were on continuous apomorphine infusion treatment. They were evaluated for their disease characteristics, satisfaction for the therapy and adverse events. Results showed that 17 patients were satisfied with the therapy. The main reason of cessation of therapy (15 patients) was subthalamic nucleus deep brain stimulation. Arrythmia and subcutaneous nodules were relatively rare (3 patients

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Trofimova, T. N., A. A. Bogdan, E. I. Vinogradova, et al. "Neuropsychiatric consequences and radiological manifestations of COVID-19." Diagnostic radiology and radiotherapy 15, no. 4 (2025): 7–22. https://doi.org/10.22328/2079-5343-2024-15-4-7-22.

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INTRODUCTION: In people who have experienced a new coronavirus infection (COVID-19), long COVID disorders can manifest as persistent cognitive and neuropsychiatric disorders that endanger daily activities and psychosocial adaptation. The long-term persistence and polymorphism of symptoms after COVID-19 is a growing concern. It is characterized by undulation, when some of the symptoms may temporarily disappear and then return again. As of 2024, the prevalence of long COVID is 6–7% in adults and about 1% in children. Using neuroimaging techniques is an integral part of the timely diagnosis of ac

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Bransfield, Robert C., Dylan M. Aidlen, Michael J. Cook, and Sagar Javia. "A Clinical Diagnostic System for Late-Stage Neuropsychiatric Lyme Borreliosis Based upon an Analysis of 100 Patients." Healthcare 8, no. 1 (2020): 13. http://dx.doi.org/10.3390/healthcare8010013.

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Many late-stage chronic Lyme disease clinical findings are neuropsychiatric. A total clinical assessment is critical in diagnosis, especially since controversy surrounds the reliability of laboratory testing. The clinical findings of one hundred Lyme disease patients with chronic neuropsychiatric symptoms were entered into a database. The prevalence of each clinical finding pre-infection and post-infection was compared and calculated within the 95% confidence interval. Patients had minimal symptoms pre-infection, but a high post-infection prevalence of a broad spectrum of acquired multisystem

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Löhle, Matthias, Wiebke Hermann, Denise Hausbrand, et al. "Putaminal Dopamine Turnover in de novo Parkinson’s Disease Predicts Later Neuropsychiatric Fluctuations but Not Other Major Health Outcomes." Journal of Parkinson's Disease 9, no. 4 (2019): 693–704. http://dx.doi.org/10.3233/jpd-191672.

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Prange, Stéphane, Teodor Danaila, Chloé Laurencin, et al. "Age and time course of long-term motor and nonmotor complications in Parkinson disease." Neurology 92, no. 2 (2018): e148-e160. http://dx.doi.org/10.1212/wnl.0000000000006737.

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ObjectiveTo determine the time course of hazard for motor and nonmotor milestones of Parkinson disease (PD) in the long term and to investigate whether risk scales nonlinearly with time is instrumental in identifying changes in pathological processes and evaluating disease-modifying therapies in PD.MethodsOutpatients with PD at the Lyon University Movement Disorders Center were evaluated for 7 clinical milestones in this retrospective cohort study, encompassing 4 domains of PD progression: (1) motor (motor fluctuations, dyskinesias); (2) axial (postural instability and falls, freezing of gait)

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18

Anderson, Rachael L., Adelene Choo, Sue Sharrad, and Ruth Withey. "Understanding Parkinson's Disease: A Basic Overview." Australasian Journal of Neuroscience 33, no. 2 (2023): 9–23. https://doi.org/10.21307/ajon-2023-012.

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Abstract Parkinson's disease (PD) is a multi-system disease, with clinical features typically described across three domains: motor, non-motor, and neuropsychiatric symptoms. There is no known cause or cure for PD, and diagnosis occurs often through a process of elimination, remaining one of clinical assessment, expert opinion, and observing disease progression over time. In the absence of disease modifying therapy for PD, pharmacological treatments play a role in symptomatic relief and improving quality of life (QoL). A narrowing therapeutic window and motor fluctuations present a challenge t

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Cotterell, Phil, Debbie Weight, Sharon Joseph, and Paul Joseph. "Complex Parkinson's disease: review and experiences." British Journal of Healthcare Assistants 13, no. 8 (2019): 394–400. http://dx.doi.org/10.12968/bjha.2019.13.8.394.

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The rate of Parkinson's disease progression is highly individual. It is important to identify those in the complex stage of the disease. Non-oral therapies may be appropriate for those in the complex stage of the disease who experience motor fluctuations, but there can be reasons for a failure to explore these options. Complex Parkinson's disease is a challenging time for the patient, their carer/s and for Parkinson's specialists. Changes to independence can be difficult to deal with, and the disease has an impact both physically and psychologically. For carers, the impact of Parkinson's can a

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Cotterell, Phil, Debbie Weight, Sharon Joseph, and Paul Joseph. "Complex Parkinson's disease: review and experiences." British Journal of Neuroscience Nursing 15, no. 3 (2019): 140–45. http://dx.doi.org/10.12968/bjnn.2019.15.3.140.

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The rate of Parkinson's disease progression is highly individual. It is important to identify those in the complex stage of the disease. Non-oral therapies may be appropriate for those in the complex stage of the disease who experience motor fluctuations, but there can be reasons for a failure to explore these options. Complex Parkinson's disease is a challenging time for the patient, their carer/s and for Parkinson's specialists. Changes to independence can be difficult to deal with, and the disease has an impact both physically and psychologically. For carers, the impact of Parkinson's can a

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Abhishek, Vadher, Vora Chitralekha, Baraiya Swati, Quraishi Ammara, Javed Hamna, and Chudasma Gayatri. "A Rare Case Of Hashimoto's Encephalopathy Responding To Plasma Exchange." British Journal of Medical and Health Research 9, no. 9 (2022): 16–20. https://doi.org/10.5281/zenodo.7270345.

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ABSTRACT Hashimoto’s encephalopathy is one of the rare causes of encephalopathy of unknown etiology. It manifests with neuropsychiatric symptoms. The estimated prevalence is 2/100,000<sup>1</sup>. Hashimoto’s encephalopathy is characterized by elevated antithyroid antibodies in absence of infections, tumors or stroke of central nervous system<sup>2-4</sup>. The disease manifests with wide array of clinical features which can be cognitive fluctuations, ataxia, myoclonus, seizures<sup>5-10</sup>. Psychitric manifestations like depression, mania, psychosis, and hallucinations have als

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Gupta, Sugandha, Mengya Wang, Yoshiaki Azuma та Nancy A. Muma. "Regulation of Serotonin 1A Receptor SUMOylation by SENP2 and PIASxα". International Journal of Molecular Sciences 22, № 24 (2021): 13176. http://dx.doi.org/10.3390/ijms222413176.

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Serotonin 1A receptors (5-HT1ARs) are implicated in the control of mood, cognition, and memory and in various neuropsychiatric disorders such as depression and anxiety. As such, understanding the regulation of 5-HT1ARs will inform the development of better treatment approaches. We previously demonstrated 5-HT1ARs are SUMOylated by SUMO1 in the rat brain. Agonist stimulation increased SUMOylation and was further enhanced when combined with 17β-estradiol-3-benzoate (EB), which are treatments that cause the transient and prolonged desensitization of 5-HT1AR signaling, respectively. In the current

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Ruiz, Marina, and Natalia Pérez. "FC20: Prevalence, Incidence, and Clinical Features of Lewy Body Dementia in the South Eastern of Spain." International Psychogeriatrics 35, S1 (2023): 81–82. http://dx.doi.org/10.1017/s1041610223001187.

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Background:Lewy body dementia (LBD) is the second most common degenerative dementia in people over 65 (1,2). LBD is underdiagnosed, with only one third of patients correctly diagnosed in daily clinical practice (3); data on the distribution of the disease are scarce. Our study was designed to measure the incidence, prevalence and clinical characteristics of LBD in south-eastern Spain. Healthcare system in Spain is free and universal.Methods:Prospective epidemiological study of LBD in San Vicente del Raspeig between October 18, 2021, and October 17, 2022. The total population aged 60 or over ba

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Kabaya, Sonoko, Chieko Greiner, Masahide Nakamura, Yuko Yamaguchi, and Hirochika Ryuno. "EXPLORATION OF STRESS FLUCTUATIONS IN FAMILY CAREGIVERS OF OLDER PEOPLE WITH MILD COGNITIVE IMPAIRMENT." Innovation in Aging 7, Supplement_1 (2023): 1035–36. http://dx.doi.org/10.1093/geroni/igad104.3328.

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Abstract Mild cognitive impairment (MCI) is common, affecting 10%-35% of people over 65, and around two-thirds overall develop dementia over their lifetime. Previous studies have reported that family caregivers (FCs) caring for older people with MCI experience considerable burden, which tends to cause various neuropsychiatric symptoms, such as depression, apathy, and irritability. However, it is not clear how FCs’ stress, which leads to increased burden, fluctuates within a day through their daily activities. The aim of this study was to explore the characteristics of stress variability in FCs

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Каменская, Валентина Г. "Психологические и психобиологические подходы к изучению поведения подростков в цифровой среде". Российский психологический журнал 21, № 1 (2024): 168–83. https://doi.org/10.21702/rpj.2024.1.9.

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Introduction. The volume of the Internet audience is rapidly growing, which encourages psychologists and medicals to study Internet addiction, psychology and psychobiology of overly Internet-addicted individuals. Internet addiction has a number of specific properties, but it has common features with chemical addictions. The question of the differential diagnosis of Internet addiction and the validity of its inclusion in the glossary of neuropsychiatric diseases remains open. The aim of the study is a theoretical analysis of the similarities and differences of dependence on digital media in com

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Osipova, N. N., L. M. Bardenstein, G. A. Aleshkina, and E. V. Dmitrieva. "The structure of affective fluctuations in a non-clinical sample." Bulletin of Siberian Medicine 20, no. 3 (2021): 79–87. http://dx.doi.org/10.20538/1682-0363-2021-3-79-87.

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Aim. To study the structure of mood fluctuations at the preclinical stage based on the findings of screening methods.Materials and methods. A total of 129 students participated in the study. The average age was 18.95 ± 0.08 years. We used the clinical and psychopathological method, the Mini-International Neuropsychiatric Interview (MINI), and screening methods, such as the diagnostic questionnaire for bipolar disorder (Hypomania Checklist-32 (HCL-32)), and Hamilton Depression Scale (HAMD-17).Results. Upon a clinical and psychopathological examination according to ICD-10 criteria, class V, ment

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Wu, Lanxiang, Qingqing Zhan, Qian Liu, et al. "Abnormal Regional Spontaneous Neural Activity and Functional Connectivity in Unmedicated Patients with Narcolepsy Type 1: A Resting-State fMRI Study." International Journal of Environmental Research and Public Health 19, no. 23 (2022): 15482. http://dx.doi.org/10.3390/ijerph192315482.

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Background: Previous Resting-state functional magnetic resonance imaging (fMRI) studies have mainly focused on cerebral functional alteration in processing different emotional stimuli in patients with narcolepsy type 1 (NT1), but were short of exploration of characteristic brain activity and its remote interaction patterns. This study aimed to investigate the spontaneous blood oxygen fluctuations at rest and to elucidate the neural mechanisms underlying neuropsychiatric behavior. Method: A total of 18 unmedicated patients with NT1 and matched healthy individuals were recruited in a resting-sta

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Chyzhyk, Darya, Manuel Graña, Döst Öngür, and Ann K. Shinn. "Discrimination of Schizophrenia Auditory Hallucinators by Machine Learning of Resting-State Functional MRI." International Journal of Neural Systems 25, no. 03 (2015): 1550007. http://dx.doi.org/10.1142/s0129065715500070.

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Auditory hallucinations (AH) are a symptom that is most often associated with schizophrenia, but patients with other neuropsychiatric conditions, and even a small percentage of healthy individuals, may also experience AH. Elucidating the neural mechanisms underlying AH in schizophrenia may offer insight into the pathophysiology associated with AH more broadly across multiple neuropsychiatric disease conditions. In this paper, we address the problem of classifying schizophrenia patients with and without a history of AH, and healthy control (HC) subjects. To this end, we performed feature extrac

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Pisu, Maria Giuseppina, Luca Concas, Carlotta Siddi, Mariangela Serra, and Patrizia Porcu. "The Allopregnanolone Response to Acute Stress in Females: Preclinical and Clinical Studies." Biomolecules 12, no. 9 (2022): 1262. http://dx.doi.org/10.3390/biom12091262.

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The neuroactive steroid allopregnanolone ((3α,5α)-3-hydroxypregnan-20-one or 3α,5α-THP) plays a key role in the response to stress, by normalizing hypothalamic-pituitary-adrenal (HPA) axis function to restore homeostasis. Most studies have been conducted on male rats, and little is known about the allopregnanolone response to stress in females, despite that women are more susceptible than men to develop emotional and stress-related disorders. Here, we provide an overview of animal and human studies examining the allopregnanolone responses to acute stress in females in the context of stress-rel

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Wasim, Bagwan1* Shivam Kumbhar2 Aaqueeb Shaikh3 Nilesh Shinde4 Ayaj Pathan5 Sohan Kotsulwar6 Sayyed Khaled7 Mansuri Toshib8 Adnan Siddiqui9. "A Review on Treatment of Parkinson`S Disease." International Journal of Pharmaceutical Sciences 3, no. 1 (2025): 2306–15. https://doi.org/10.5281/zenodo.14752422.

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Parkinson’s disease is indeed a complex and progressive neurodegenerative disorder characterized by both motor and non-motor symptoms. Management focuses primarily on palliative care, aiming to enhance quality of life over the course of the disease, which can span several decades. Device-assisted therapies, such as deep brain stimulation, apomorphine pumps, and levodopa gel intestinal infusion, have revolutionized the treatment of advanced Parkinson's disease. These interventions can help manage motor fluctuations and improve overall function. Non-motor symptoms, including neuropsychiatr

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Wasim, Bagwan Nilesh Shinde* Sohan Kotsulwar. "A Review on Treatment of Parkinson`S Disease." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 3356–65. https://doi.org/10.5281/zenodo.15307778.

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Parkinson’s disease is indeed a complex and progressive neurodegenerative disorder characterized by both motor and non-motor symptoms. Management focuses primarily on palliative care, aiming to enhance quality of life over the course of the disease, which can span several decades. Device-assisted therapies, such as deep brain stimulation, apomorphine pumps, and levodopa gel intestinal infusion, have revolutionized the treatment of advanced Parkinson's disease. These interventions can help manage motor fluctuations and improve overall function. Non-motor symptoms, including neuropsychiatr

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Krejčí, Milada, and Dobroslava Jandová. "Homeostasis and balance in senium." Acta Salus Vitae 8, no. 2 (2020): 14–27. http://dx.doi.org/10.58743/asv2020vol8no2.240.

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The body's homeostasis ensures the individual's survival in a constantly changing environment, such as changes and fluctuations of temperature, humidity, pressure, etc. The central nervous system and cardiovascular system play a priority in maintaining homeostasis. State of balance is closely related to the theory of homeostasis and homedynamics, where the term homeostasis is characterized as the tendency of the organism to a relatively stable balance between interdependent elements maintained by physiological processes. The study is aimed on content and descriptive analysis of the context of

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Cagnin, Annachiara, Cinzia Bussè, Simona Gardini, et al. "Clinical and Cognitive Phenotype of Mild Cognitive Impairment Evolving to Dementia with Lewy Bodies." Dementia and Geriatric Cognitive Disorders Extra 5, no. 3 (2015): 442–49. http://dx.doi.org/10.1159/000441184.

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Objective: The aim of this study was to determine which characteristics could better distinguish dementia with Lewy bodies (DLB) from Alzheimer's disease (AD) at the mild cognitive impairment (MCI) stage, with particular emphasis on visual space and object perception abilities. Methods: Fifty-three patients with mild cognitive deficits that were eventually diagnosed with probable DLB (MCI-DLB: n = 25) and AD (MCI-AD: n = 28) at a 3-year follow-up were retrospectively studied. At the first visit, the patients underwent cognitive assessment including the Qualitative Scoring Mini Mental State Exa

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Krukow, Paweł, Małgorzata Plechawska-Wójcik, and Arkadiusz Podkowiński. "Manipulations of the Response-Stimulus Intervals as a Factor Inducing Controlled Amount of Reaction Time Intra-Individual Variability." Brain Sciences 11, no. 5 (2021): 669. http://dx.doi.org/10.3390/brainsci11050669.

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Aggrandized fluctuations in the series of reaction times (RTs) are a very sensitive marker of neurocognitive disorders present in neuropsychiatric populations, pathological ageing and in patients with acquired brain injury. Even though it was documented that processing inconsistency founds a background of higher-order cognitive functions disturbances, there is a vast heterogeneity regarding types of task used to compute RT-related variability, which impedes determining the relationship between elementary and more complex cognitive processes. Considering the above, our goal was to develop a rel

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De Benedictis, Chiara A., Claudia Haffke, Simone Hagmeyer, Ann Katrin Sauer, and Andreas M. Grabrucker. "Expression Analysis of Zinc Transporters in Nervous Tissue Cells Reveals Neuronal and Synaptic Localization of ZIP4." International Journal of Molecular Sciences 22, no. 9 (2021): 4511. http://dx.doi.org/10.3390/ijms22094511.

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In the last years, research has shown that zinc ions play an essential role in the physiology of brain function. Zinc acts as a potent neuromodulatory agent and signaling ions, regulating healthy brain development and the function of both neurons and glial cells. Therefore, the concentration of zinc within the brain and its cells is tightly controlled. Zinc transporters are key regulators of (extra-) cellular zinc levels, and deregulation of zinc homeostasis and zinc transporters has been associated with neurodegenerative and neuropsychiatric disorders. However, to date, the presence of specif

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Arora, Anshu, and Peter Fletcher. "Problem based review: A patient with Parkinson’s disease." Acute Medicine Journal 12, no. 4 (2013): 246–50. http://dx.doi.org/10.52964/amja.0327.

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Parkinson’s disease (PD) is a chronic, progressive neurodegenerative disease characterized by bradykinesia, tremor and/ or rigidity, often with gait disturbance and postural instability. In addition to these typical features, patients with PD may experience further problems related to the disease itself or to the medications used to treat it. These comorbid problems include neuropsychiatric conditions (including psychosis, hallucinations, excessive daytime sleepiness, anxiety, depression, fatigue and dementia) as well as problems associated with autonomic nervous system function such as bowel

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Allkoja, B., E. Mitro, B. Zenelaj, and V. Alikaj. "Relationship Between Brain Structural Abnormalities and Early Onset Psychotic Disorder–case Presentation." European Psychiatry 41, S1 (2017): s800—s801. http://dx.doi.org/10.1016/j.eurpsy.2017.01.1544.

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IntroductionContemporary structural models of several psychiatric disorders propose abnormalities in the structure and function of distinct neural networks. Clinical observations of affective and cognitive changes arising from cerebellar lesions and stimulation permit the hypothesis that the cerebellum may not be irrelevant in some neuropsychiatric states. There is evidence that patients with schizophrenia have altered corticocerebellar connectivity.ObjectivesTo evidence a case with early onset psychosis accompanied with brain structural abnormalities.MethodCase description.ResultsThe patient

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Chin, Kai Sin, Andrew Teodorczuk, and Rosie Watson. "Dementia with Lewy bodies: Challenges in the diagnosis and management." Australian & New Zealand Journal of Psychiatry 53, no. 4 (2019): 291–303. http://dx.doi.org/10.1177/0004867419835029.

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Objective: Dementia with Lewy bodies is the second most common form of neurodegenerative dementia in older age yet is often under-recognised and misdiagnosed. This review aims to provide an overview of the clinical features of dementia with Lewy bodies, discussing the frequent challenges clinicians experience in diagnosing dementia with Lewy bodies, and outlines a practical approach to the clinical management, particularly in the Australian setting. Methods: This paper is a narrative review and a semi-structured database (PubMed and MEDLINE) search strategy was implemented. Articles were scree

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da Silva, Aline Cristina Couto, Délio Tiago Martins Malaquias, Juliana Fontes Beltran Paschoal, et al. "ADVANCES IN THE TREATMENT OF PARKINSONISM WITH DEEP BRAIN STIMULATION." International Seven Journal of Multidisciplinary 4, no. 1 (2025): 99–115. https://doi.org/10.56238/isevmjv4n1-010.

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Deep Brain Stimulation (DBS) has established itself as one of the most effective treatments for Parkinson's Disease (PD), especially in patients with motor symptoms refractory to drug therapy. This review article aims to address recent advances in the application of DBS, highlighting technological improvements, clinical efficacy and challenges associated with the technique. Scientific evidence shows that DBS provides significant improvements in motor symptoms such as tremors, rigidity and dyskinesias, as well as reducing motor fluctuations related to prolonged levodopa use. Technological advan

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Echeverria, C., J. Libuy, J. Alarcón, and J. Rodriguez. "ELECTROCONVULSIVE THERAPY FOR AGITATION IN LEWY BODIES DEMENTIA." European Psychiatry 66, S1 (2023): S1020—S1021. http://dx.doi.org/10.1192/j.eurpsy.2023.2167.

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IntroductionDementia with Lewy Bodies (DLB) is a primary degenerative dementing syndrome characterized by visual hallucinations, fluctuation in cognition, depressive symptoms and parkinsonism. Literature has shown the utility of electroconvulsive therapy (ECT) in demented patients regarding depressive symptoms and agitation. Nevertheless, the majority of cases described include patients with vascular dementia and Alzheimer’s disease. There are no cases informed concerning ECT in DLB patients with agitation and aggressive behaviors.ObjectivesEvaluate the impact of electroconvulsive therapy (ECT

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Chen, Wei, Maode Wang, Ning Wang, Changwang Du, Xudong Ma, and Qi Li. "The Impacts of Subthalamic Nucleus-Deep Brain Stimulation (STN-DBS) on the Neuropsychiatric Function of Patients with Parkinson’s Disease Using Image Features of Magnetic Resonance Imaging under the Artificial Intelligence Algorithms." Contrast Media & Molecular Imaging 2021 (July 8, 2021): 1–7. http://dx.doi.org/10.1155/2021/9915206.

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This study was to explore the effect of subthalamic nucleus- (STN-) deep brain stimulation (DBS) on the neuropsychiatric function of Parkinson’s disease (PD) patients using the magnetic resonance imaging (MRI) image analysis technology and the artificial intelligence (AI) algorithm. In this study, 40 PD patients admitted to our hospital from August 2018 to March 2020 were selected as the research objects, and they were divided into a control group and an observation group according to the random number table method, with 20 cases in each group. The patients in the control group were given oral

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Santos García, Diego, María Álvarez Sauco, Matilde Calopa, et al. "MNCD: A New Tool for Classifying Parkinson’s Disease in Daily Clinical Practice." Diagnostics 12, no. 1 (2021): 55. http://dx.doi.org/10.3390/diagnostics12010055.

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Background and objective: Parkinson’s disease (PD) is a clinically heterogeneous disorder in which the symptoms and prognosis can be very different among patients. We propose a new simple classification to identify key symptoms and staging in PD. Patients and Methods: Sixteen movement disorders specialists from Spain participated in this project. The classification was consensually approved after a discussion and review process from June to October 2021. The TNM classification and the National Institutes of Health Stroke Scale (NIHSS) were considered as models in the design. Results: The class

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Calabresi, Paolo, Veronica Ghiglieri, Petra Mazzocchetti, Ilenia Corbelli, and Barbara Picconi. "Levodopa-induced plasticity: a double-edged sword in Parkinson's disease?" Philosophical Transactions of the Royal Society B: Biological Sciences 370, no. 1672 (2015): 20140184. http://dx.doi.org/10.1098/rstb.2014.0184.

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The long-term replacement therapy with the dopamine (DA) precursor 3,4-dihydroxy-l-phenylalanine (L-DOPA) is a milestone in the treatment of Parkinson's disease (PD). Although this drug precursor can be metabolized into the active neurotransmitter DA throughout the brain, its therapeutic benefit is due to restoring extracellular DA levels within the dorsal striatum, which lacks endogenous DA as a consequence of the neurodegenerative process induced by the disease. In the early phases of PD, L-DOPA treatment is able to restore both long-term depression (LTD) and long-term potentiation (LTP), tw

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Liao, Jiangfeng, Yusi Zhang, Jianwei Yang, Longfei Chen, Jing Zhang, and Xiaochun Chen. "Peroxiredoxin 6 in Stress Orchestration and Disease Interplay." Antioxidants 14, no. 4 (2025): 379. https://doi.org/10.3390/antiox14040379.

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As a moonlighting protein with multiple enzymatic activities, peroxiredoxin 6 (PRDX6) maintains redox homeostasis, regulates phospholipid metabolism, and mediates intra- and inter-cellular signaling transduction. Its expression and activity can be regulated by diverse stressors. However, the roles and relevant mechanisms of these regulators in various conditions have yet to be comprehensively reviewed. In this study, these stressors were systematically reviewed both in vivo and in vitro and classified into chemical, physical, and biological categories. We found that the regulatory effects of t

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Sobolevskaia, P. A., A. N. Gvozdeckii, I. V. Kudryavtsev, V. A. Chereshnev, and L. P. Сhurilov. "Role of proinflammatory cytokines in Hashimoto's thyroiditis associated with psychiatric disorders." Medical Immunology (Russia) 25, no. 5 (2023): 1247–52. http://dx.doi.org/10.15789/1563-0625-rop-2812.

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Mental disorders often accompany autoimmune diseases, for example, since 1949 it has been known about “myxedematous madness”, a psychosis caused by hypothyroidism. The most common cause of hypothyroidism is Hashimoto's autoimmune thyroiditis. It is also known about another neuropsychiatric disorder associated with autoimmune thyroiditis, Hashimoto's encephalopathy. It is a severe dysfunction of the central nervous system, the pathogenesis of which is not associated with hormonal disorders. Cytokines are regulators and participants of inflammation, including autoimmune. Certainly, when we are t

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Missig, Galen, James O. Robbins, Emery L. Mokler, et al. "Sex-dependent neurobiological features of prenatal immune activation via TLR7." Molecular Psychiatry 25, no. 10 (2019): 2330–41. http://dx.doi.org/10.1038/s41380-018-0346-4.

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Abstract Immune activation during pregnancy via infection or autoimmune disease is a risk factor for neuropsychiatric illness. Mouse models of prenatal immune activation often involve maternal administration of agents that activate toll-like receptors (TLRs), a class of pattern recognition receptors that initiate innate immune responses. Such studies have focused primarily on activating the TLR3 or TLR4 subtypes, to mimic immune responses to viral or bacterial infections, respectively. Here, we characterize the effects of prenatal activation of TLR7, which is implicated in the pathogenesis of

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Moneglia, M., A. Santangelo, I. Burian, et al. "Second generation direct-acting antiviral (DAAs) Treatment on HCV+ patients: Patient reported outcomes (PROs) and psychiatric symptoms in a real world setting sample." European Psychiatry 41, S1 (2017): S316—S317. http://dx.doi.org/10.1016/j.eurpsy.2017.02.230.

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IntroductionAnti-HCV treatments are moving away from interferon-alpha towards DAAs, associated with fewer side effects, better tolerability, and better PROs.AimsTo describe neuropsychiatric symptoms and PROs during DAAs treatment in a group of HCV+ patients.MethodsForty outpatients, scheduled for DAAs treatment, were assessed at enrolment (T0), 4 weeks (T1), at the end of treatment (EOT) and after 12 weeks of follow up (F-UP), by means of MDRS, HAM-D, HAM-A, MRS, Y-BOCS and SF-36. Afterwards the sample was divided into two groups as a function of a positive psychiatric history (19) and compare

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Matar, Elie, Kaylena A. Ehgoetz Martens, Glenda M. Halliday, and Simon JG Lewis. "093 How to diagnose lewy body dementia? Prevalence and underlying relationship between clinical and neuropsychological features of DLB." Journal of Neurology, Neurosurgery & Psychiatry 90, e7 (2019): A30.1—A30. http://dx.doi.org/10.1136/jnnp-2019-anzan.81.

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IntroductionDespite its importance for management, prognostication and selection of patients for clinical trials, the diagnosis of Dementia with Lewy Bodies (DLB) remains challenging. Complicating this is a recent change in the diagnostic criteria which has arguably shifted the expected phenotype of DLB patients. In this study we aimed to characterize and examine the relationship between cognitive and clinical diagnostic variables in DLB patients to uncover latent symptom clusters that may streamline future diagnostic approaches in the clinic.MethodsThe clinical and neuropsychological profile

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Putilina, M. V. "Back pain in elderly patients with locomotive syndrome: Focus on efficacy and safety." Meditsinskiy sovet = Medical Council, no. 3 (April 12, 2025): 82–88. https://doi.org/10.21518/ms2025-069.

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Back and joint pain occur in 70% of patients aged 60 years and older. The presence of arterial hypertension (AH), cerebrovascular diseases (strokes, heart attacks, chronic heart failure, ischemic heart disease), diabetes mellitus create significant obstacles to the choice of therapy. In 2007, the term “locomotive syndrome” (LS) appeared in world practice, proposed by the Japanese Orthopedic Association to characterize elderly patients with unstable balance, a tendency to fall, due to structural and functional damage to the organs of the nervous and musculoskeletal systems. Chronic musculoskele

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Bacanoiu, Manuela Violeta, Ligia Rusu, Mihnea Ion Marin, et al. "Digital Health in Parkinson’s Disease and Atypical Parkinsonism—New Frontiers in Motor Function and Physical Activity Assessment: Review." Journal of Clinical Medicine 14, no. 12 (2025): 4140. https://doi.org/10.3390/jcm14124140.

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In addition to axial motor complications such as abnormal posture, instability, falls, and gait variability, neurodegenerative diseases like Parkinsonian syndromes include executive dysfunction, Parkinson’s disease dementia, and neuropsychiatric symptoms. These motor disorders significantly affect mobility, quality of life, and well-being. Recently, physical activity of various intensities monitored both remotely and face-to-face via digital health technologies, mobile platforms, or sensory cues has gained relevance in managing idiopathic and atypical Parkinson’s disease (PD and APD). Remote m

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