Relevant bibliographies by topics / Neuroradiologia

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Neuroradiologia'

Author: Grafiati
Published: 21 February 2023
Last updated: 14 March 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Neuroradiologia.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Neuroradiologia"

1

Passerini, A. "Storia della Neuroradiologia europea." Rivista di Neuroradiologia 7, no. 4 (August 1994): 541–56. http://dx.doi.org/10.1177/197140099400700401.

Full text
Abstract:
La storia della Neuroradiologia è dispersa nelle pagine delle Riviste di Fisica, di Radiologia, di Otorinolaringologia, di Anatomia Patologica, di Neurologia, di Neurochirurgia, di Neuroradiologia ed è poco nota ai giovani neuroradiologi. Non è definito il periodo al quale risale il primo im-piego del termine «Neuroradiologia». «A Short History of Neuroradiology» è stata pubblicata da Herman Fischgold e da James Bull in occasione dell'VIII Symposium Neuroradiologicum tenuto a Parigi nel settembre 1967. Emmanuel Cabanis ha voluto continuarne la tradizione e, in occasione del XVI Congresso della SocieAà Europea di Neuroradiologia, tenuto ancora a Parigi nel luglio 1989, ha ristampato con il titolo «Contribution a l'histoire de la Neuroradiologie Européenne» il testo di Fischgold e di Bull con l'aggiornamento dei successivi 22 anni e con l'aggiunta dei principali articoli comparsi su riviste mediche e tecniche che ricordano la tappe della diffusione e del rivoluzionario progresso della Neuroradiologia nell'ambito mondiale: integrano queste due, altre storie della Neuroradiologia pubblicate nei classici testi di Neuroradiologia da Lindgren, da Deck, da Newton e Kerber e da altri autori.
APA, Harvard, Vancouver, ISO, and other styles
2

Dellagiustina, E., L. Mavilla, M. Sintini, and A. Guerra. "Neuroradiologia della sindrome di Alpers." Rivista di Neuroradiologia 5, no. 1_suppl (April 1992): 169–72. http://dx.doi.org/10.1177/19714009920050s135.

Full text
Abstract:
Si segnala la particolare evoluzione neuroradiologica di una piccola paziente, che ha attualmente a.2 e m. 10, e che a seguito di un coma metabolico con stato di male epilettico, iperlattacidemia, epatopatia moderata, anomalie lente sull'EEGramma, ha cominciato all'età di 3 mesi ad eseguire accertamenti neuroradiologici. la TC a quell'età mostrò solo una lievissima atrofia cerebrale con ipodensità irregolare della sostanza bianca. All'età di 6 mesi, allorquando fu posta la diagnosi di sindrome di Alpers, la RM metteva in evidenza un quadro di gravissima atrofia degli emisferi cerebrali, sia corticale che sottocorticale, e, in minor misura, di quelli cerebellari, con relativo risparmio dei nuclei della base e del tronco cerebrale. L'evoluzione atrofica era stata talmente rapida da indurre in tre mesi anche la formazione di due voluminosi ematomi sottodurali. La RM fu decisiva per confermare il sospetto diagnostico. Da allora, la condizione clinica neurologica e metabolica della paziente, in trattamento con dosi elevate di carnitina e vit. Bl, oltre che con anticomiziali, si è stabilizzata. Anche il quadro neuroradiologico si mantiene sostanzialmente invariato, fatta eccezione per il riassorbimento dei due ematomi sottodurali. Le indagini metaboliche approfondite hanno permesso di dimostrare un difetto di attivazione del complesso piruvato-deidrogenasi. La RM si dimostra esame indispensabile per la diagnosi di questa rara malattia, e superiore alla TC. A nostra conoscenza è questo il primo studio neuroradiologico prospettico della sindrome di Alpers.
APA, Harvard, Vancouver, ISO, and other styles
3

Farabola, M. "Perspectives of Milan Neuroradiology Orizzonti Della Neuroradiologia Milanese." Rivista di Neuroradiologia 7, no. 3 (June 1994): 467–68. http://dx.doi.org/10.1177/197140099400700312.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Scotti, G., and M. Leonardi. "I Neuroradiologi Italiani e la Società Europea di Neuroradiologia." Rivista di Neuroradiologia 3, no. 1 (February 1990): 19–20. http://dx.doi.org/10.1177/197140099000300103.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

D'Amico, A., and F. Triulzi. "NEURORADIOLOGIA PEDIATRICA." Neuroradiology Journal 22, no. 6 (December 2009): 717–19. http://dx.doi.org/10.1177/197140090902200632.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Scotti, G. "Neuroradiologia diagnostica." Rivista di Neuroradiologia 6, no. 1 (February 1993): 11–14. http://dx.doi.org/10.1177/197140099300600102.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Salvolini, U. "Neuroradiologia ad Ancona." Rivista di Neuroradiologia 7, no. 1 (February 1994): 27–28. http://dx.doi.org/10.1177/197140099400700103.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Pierallini, A., M. Bonamini, D. Di Stefano, L. M. Fantozzi, G. Cantore, and L. Bozzao. "Neuroradiologia degli astrocitomi." Rivista di Neuroradiologia 7, no. 1_suppl (May 1994): 15–21. http://dx.doi.org/10.1177/19714009940070s104.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Mavilio, N., S. Ballerini, D. Capello, R. Bragazzi, E. Marinaro, S. Schiavoni, and M. L. Rosa. "Neuroradiologia dell'astrocytoma pilocitico." Rivista di Neuroradiologia 7, no. 1_suppl (May 1994): 27–31. http://dx.doi.org/10.1177/19714009940070s106.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Moschini, L., and C. Agostinis. "Neuroradiologia dei paragangliomi." Rivista di Neuroradiologia 9, no. 5 (October 1996): 577–93. http://dx.doi.org/10.1177/197140099600900511.

Full text
Abstract:
I paragangliomi rappresentano un sistema multicentrico con funzione chemo e barocettrice costituito da numerose strutture sostanzialmente ubiquitarie situate in stretta relazione anatomica con vasi e nervi. La patologia dei paragangliomi è essenzialmente tumorale. Nella maggior parte dei casi si tratta di tumori benigni non secernenti che si manifestano per l'effetto massa e per la compressione di organi adiacenti. Risultano più frequenti nel sesso femminile e nella 3a e 4a decade di vita. Per quanto riguarda il distretto cranio-cervicale, si riconoscono quattro sedi principali: in ordine di frequenza, carotidea, giugulare, timpanica e vagale. Questi tumori si presentano sia sporadicamente, sia nel 10% dei casi in forme famigliari con meccanismo di trasmissione autosomico dominante. Il protocollo diagnostico si basa sulla RM, sulla TC e sull'angiografia digitale, che con il ricorso all'embolizzazione preoperatoria può rappresentare anche l'inizio del programma terapeutico.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Neuroradiologia"

1

TORTORA, DOMENICO. "Role of the advanced MRI sequences in predicting the outcome of preterm neonates." Doctoral thesis, Università degli studi di Genova, 2019. http://hdl.handle.net/11567/982395.

Full text
Abstract:
AIM The aim of the project is to evaluate the role of advanced MRI sequences (susceptibility weight imaging (SWI), diffusion tensor imaging (DTI), and arterial spin labeling (ASL) perfusion) in detecting early changes that affect preterm neonatal brain, especially in those patients without lesions at conventional MRI or with small brain injuries (i.e. low grade germinal matrix-intraventricular hemorrhage (GMHIVH)), and to correlate these subtle brain abnormalities with neurodevelopmental outcome at 24 months. METHODS Since November 2015 until June 2017, 287 preterm neonates and 108 term neonates underwent a 3T or 1.5T MRI study at term corrected age (40±1 weeks). SWI, DTI and ASL sequences were performed in all neonates. SWI sequences were evaluated using both a qualitative (SWI venography) and quantitative (Quantitative Susceptibility Map analysis (SWI-QSM)) approach. DTI data were analyzed using a Tract-Based Spatial Statistics analysis (TBSS). ASL studies were processed to estimate Cerebral Blood Flow (CBF) maps. Perinatal clinical data were collected for all neonates. Neurodevelopmental data were evaluated at 24 months in 175 neonates using 0-2 Griffiths Developmental Scales. RESULTS The analysis performed on SWI-venography revealed differences in subependymal veins morphology between preterm and term neonates with normal brain MRI, with a higher variability from the typical anatomical pattern in preterm neonates. The same analysis performed in preterm neonates with GMH-IVH revealed that the anatomical features of subependymal veins may play a potential role as predisposing factor for GMH-IVH. Moreover, the SWI-QSM analysis revealed a greater paramagnetic susceptibility in several periventricular white matter (WM) regions in preterm neonates with GMH-IVH than in healthy controls. This finding is likely related to the accumulation of hemosiderin/ferritin following the diffusion of large amounts of intraventricular blood products into the WM, and it is also supposed to trigger the cascade of lipid peroxidation and free radical formation that promote oxidative and inflammatory injury of the WM in neonatal brain after GMH-IVH. The TBSS analysis confirmed that microstructural WM injury can occur in preterm neonates with low grade GMH-IVH even in the absence of overt signal changes on conventional MRI, with different patterns of WM involvement depending on gestational age. Moreover, the distribution of these WM microstructural alterations after GMH-IVH correlates with specific neurodevelopmental impairments at 24 months of age. Finally, the analysis of brain perfusion at term-corrected age revealed lower CBF in preterms with sub-optimal neuromotor development, reinforcing the hypothesis that impaired autoregulation of CBF may contribute to the development of brain damage in preterm neonates. CONCLUSION Advanced MRI sequences can assist the standard perinatal brain imaging in the early diagnosis of preterm neonatal brain lesions and can provide new insights for predicting the neurodevelopmental trajectory. However, detailed and serial imaging of carefully chosen cohorts of neonates coupled with longer clinical follow-up are essential to ensure the clinical significance of these novel findings.
APA, Harvard, Vancouver, ISO, and other styles
2

Cristofaro, Antonella Pia. "Imaging Diagnostico utilizzato in neuroradiologia per lo studio degli Aneurismi Cerebrali." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/9942/.

Full text
Abstract:
Durante la mia tesi mi sono occupata di una grave patologia, l’Aneurisma Cerebrale, che rappresenta una delle principali cause di ospedalizzazione provocando il 10/12% della mortalità globale annua nei paesi industrializzati. In Italia , l’incidenza di aneurismi cerebrali è di 100.000 nuovi casi all’anno. In generale , nei paesi industrializzati, la prevalenza è stimata a circa 600 per 100.000 abitanti . Tuttavia la prevalenza degli aneurismi cerebrali nelle popolazioni in generale , è molto più elevato stimato intorno al 2,3%,il che suggerisce indirettamente che la maggior parte degli aneurismi non va mai incontro a rottura. Negli ultimi vent’anni lo sviluppo della tecnologia ha visto significativi progressi che ci hanno permesso di agire sul problema in modo sempre migliore. Nei primi capitoli ho descritto alcune apparecchiature biomediche che sono di fondamentale importanza nello studio degli aneurismi cerebrali, mettendo in evidenza le varie peculiarità che le contraddistinguono. A seguire, ho parlato del trattamento endovascolare, che consiste nell’esclusione della cavità aneurismatica dal flusso di sangue, il quale viene incanalato in una protesi posizionata all’interno del lume vasale eliminando il rischio di rottura o di embolizzazione di materiale trombotico proveniente dalla sacca aneurismatica. I vantaggi della tecnica endovascolare consistono nella minore invasività rispetto alla tecnica chirurgica standard, la craniotomia. A fronte di ciò, si deduce quanto l’ingegneria biomedica sia una disciplina in evoluzione. Le condizioni di vita delle persone che subiscono questi tipi di interventi sono notevolmente migliorate ottenendo risultati di completa o semi-completa guarigione.
APA, Harvard, Vancouver, ISO, and other styles
3

Magalhães, João Maria Fonseca Moreira Coelho de. "A neuroradiologia de intervenção no tratamento do acidente vascular cerebral isquémico." Master's thesis, Faculdade de Medicina da Universidade do Porto, 2010. http://hdl.handle.net/10216/61007.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Magalhães, João Maria Fonseca Moreira Coelho de. "A neuroradiologia de intervenção no tratamento do acidente vascular cerebral isquémico." Dissertação, Faculdade de Medicina da Universidade do Porto, 2010. http://hdl.handle.net/10216/61007.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Giovenzana, Alessia. "Interaction between language and analogical reasoning from the brain imaging perspective." Doctoral thesis, Università degli studi di Trento, 2011. https://hdl.handle.net/11572/368911.

Full text
Abstract:
The main aim of this works is to explore the relationship between language and analogical reasoning. In fact, despite the increasing interest about the neural substrates of reasoning, at present no fMRI study systematically investigates the contribution of stimulus format/context on reasoning network. In the present work three fMRI studies are developed in order to verify how much reasoning relies on verbal language using different stimuli format and within normal and a language impaired populations. The first study focus on how different verbal context, nameable pictures versus words, may influence brain activity related to analogical reasoning in healthy adults. In a second study the same fMRI paradigm was applied to investigate brain activity during analogical reasoning in young normal readers and young dyslexics in order to understand if the reading disorder may influence the reasoning in relation to the language load requested by the stimulus format. In the third study the contribution of language and semantic system to reasoning was investigate developing a new fMRI design where analogical reasoning had to be performed either on meaningful or on abstract geometrical pictures.
APA, Harvard, Vancouver, ISO, and other styles
6

Giovenzana, Alessia. "Interaction between language and analogical reasoning from the brain imaging perspective." Doctoral thesis, University of Trento, 2011. http://eprints-phd.biblio.unitn.it/628/1/Giovenzana_A_PhDThesis.pdf.

Full text
Abstract:
The main aim of this works is to explore the relationship between language and analogical reasoning. In fact, despite the increasing interest about the neural substrates of reasoning, at present no fMRI study systematically investigates the contribution of stimulus format/context on reasoning network. In the present work three fMRI studies are developed in order to verify how much reasoning relies on verbal language using different stimuli format and within normal and a language impaired populations. The first study focus on how different verbal context, nameable pictures versus words, may influence brain activity related to analogical reasoning in healthy adults. In a second study the same fMRI paradigm was applied to investigate brain activity during analogical reasoning in young normal readers and young dyslexics in order to understand if the reading disorder may influence the reasoning in relation to the language load requested by the stimulus format. In the third study the contribution of language and semantic system to reasoning was investigate developing a new fMRI design where analogical reasoning had to be performed either on meaningful or on abstract geometrical pictures.
APA, Harvard, Vancouver, ISO, and other styles
7

DONISELLI, FABIO MARTINO. "NEW ADVANCES IN QUANTITATIVE RADIOLOGY: RADIOMICS IN NEURORADIOLOGY APPLIED TO PRIMARY BRAIN TUMORS USING A MACHINE LEARNING APPROACH." Doctoral thesis, Università degli Studi di Milano, 2022. http://hdl.handle.net/2434/932853.

Full text
Abstract:
Arterial spin labelling (ASL) radiomics analysis to predict IDH mutation and MGMT methylation status in gliomas Fabio M. Doniselli1,2, Riccardo Pascuzzo1, Eleonora Bruno3, Domenico Aquino1, Mattia Verri, Alberto Redolfi, Valeria Cuccarini1, Marco Moscatelli1,2, Maria Grazia Bruzzone1, Luca Maria Sconfienza2,4 Abstract Objectives: To evaluate the strength and ability of radiomics features extracted from multiple tumor subregions on MR brain images to predict MGMT promoter (MGMT) methylation status and isocitrate dehydrogenase (IDH) mutation in glioma patients through a multiparametric MRI-based radiomics model, using arterial-spin labelling (ASL) perfusion imaging. Methods: Retrospective single-institution study in a cohort of 52 glioma patients. Radiomics-based models with a minimal set of relevant features and clinical parameters were built for MGMT methylation and IDH-mutation prediction from a training cohort (31 patients) and tested on an validation cohort (13 patients). Results: Feature selection methods (Boruta, RFE and LR-EL) identified age and 3 radiomics features for MGMT prediction and 3 features for IDH prediction. For IDH prediction, SVM classifier achieved average 96.8% accuracy and 0.929 AUC during the training phase, and 84.6% accuracy and 0.60 AUC on the test set. For MGMT methylation prediction, SVM classifier achieved average 67.7% accuracy and 0.765 AUC during the training phase, and 38.5% accuracy and 0.429 AUC on the test set. Conclusions: The classification model based on both demographic (age) and radiomic ASL perfusion characteristics had the best performance in predicting the IDH mutational status of gliomas. This result suggests that the proposed method has promising efficacy in predicting IDH mutational status. We have not obtained a sufficient result trying to correlate radiomics with the MGMT mutational pattern.
Assessment of quality and classification performances of MRI-based radiomics studies on MGMT methylation in gliomas: a systematic review Fabio M. Doniselli1,2*, Riccardo Pascuzzo1*, Massimiliano Agrò3, Domenico Aquino1, Federica Mazzi1, Francesco Padelli1, Marco Moscatelli1, Maria Grazia Bruzzone1, Luca M. Sconfienza2,4 Objectives To evaluate the quality of MRI-based radiomics studies predicting the O6-methylguanine-DNA methyltransferase (MGMT) methylation status in gliomas, using radiomics quality score (RQS) and Image Biomarkers Standardization Initiative (IBSI) guidelines, and examine their classification performance. Methods PubMed Medline and EMBASE were searched to identify MRI-based radiomics studies on MGMT methylation in gliomas until January 31, 2022. Included studies were scored according to RQS (16 components) and IBSI (six items) scales by two raters. Results We included 20 out of 62 identified studies. The median RQS total score was 32% of the maximum (11.5 out of 36), ranging between 8% and 44%. Eleven studies performed external validation; only three studies performed decision curve analysis to report potential clinical utility. All studies reported area under the curve (AUC) or accuracy, and 14 computed these statistics using resampling methods (e.g., cross-validation). No study performed phantom study, cost-effectiveness analysis, and prospective validation. Regarding IBSI items, 14 studies (70%) performed signal intensity normalization, while few performed N4 bias-field correction (4, 20%) and skull stripping (3, 15%). Good classification performance (AUC>0.75) was obtained by 11 (55%) studies, but only four of them performed external validation (on sets with 20-60 patients). On the contrary, seven out of the nine studies with lower classification results performed external validation (on sets with 27-126 patients). Conclusions Adherence to RQS and IBSI guidelines was generally low. MGMT methylation status appears to be correlated with radiomic features, but with great heterogeneity of results. To confirm this trend, strict implementation of RQS and IBSI criteria is needed.
Radiomics for MGMT methylation detection in GBM using conventional pre-operative MRI Fabio M. Doniselli1,2, Riccardo Pascuzzo1, Massimiliano Agrò3, Domenico Aquino1, Elena Anghileri, Bianca Pollo, Valeria Cuccarini1, Marco Moscatelli1, Francesco DiMeco, Maria Grazia Bruzzone1, Luca M. Sconfienza2,4 Abstract Objectives: To evaluate the strength and ability of radiomics features extracted from multiple tumor subregions on MR brain images to predict MGMT promoter (MGMT) methylation status in GBM patients through a multiparametric MRI-based radiomics model. Methods: Retrospective single-institution study in a cohort of 277 GBM patients. Radiomics-based models with a minimal set of relevant features and clinical parameters were built for MGMT methylation prediction from a training cohort (196 patients) and tested on an validation cohort (81 patients). Radiomic Quality Score (RQS) was equal to 15. Results: Feature selection methods (Boruta, RFE and LR-EL) identified age and 218 radiomics features. SVM classifier achieved average 73.6% (standard deviation: 6.5%) accuracy and 0.836 (0.054) AUC during the training phase, and 59.3% (95% confidence interval: 47.8%-70.0%) accuracy and 0.553 (0.412-0.686) AUC on the test set. Conclusions: We agree on the probable presence of subtle association between imaging characteristics and MGMT methylation status. However, further verification on the strength of this association is needed, as the low diagnostic performance in the validation cohort is still not sufficiently robust to allow clinically meaningful predictions.
APA, Harvard, Vancouver, ISO, and other styles
8

MIGNOGNA, Donatella. "Analysis of the role of the neuronal receptor LRP8 in the production of exosomes in a cellular model and in the context of Alheimer's disease." Doctoral thesis, Università degli studi del Molise, 2021. http://hdl.handle.net/11695/100707.

Full text
Abstract:
Un numero crescente di evidenze ha rivelato che alterazioni del sistema endosomiale-lisosomiale sono collegate ad un malfunzionamento nello smistamento di diverse proteine, portando ad una significativa alterazione della stessa omeostasi proteica. Queste alterazioni risultano particolarmente compromettenti nel campo delle malattie neurodegenerative. In questo scenario, gli esosomi, vescicole extracellulari derivate dal sistema endosomiale-lisosomiale, che riflettono le alterazioni presenti nelle cellule che le hanno prodotte, hanno attirato l'attenzione della comunità scientifica, come possibili marcatori precoci di malattia. Nel campo della malattia di Alzheimer, gli esosomi hanno dimostrato la capacità di ridurre la beta-amiloide cerebrale coinvolgendo l'assorbimento microgliale e gli effetti negativi come la diffusione della tau iperfosforilata, quindi potrebbero essere coinvolti nei meccanismi di apoptosi e, in ultima analisi, contribuire alla degenerazione dendritica. L'espressione dell'apolipoproteina E4, il fattore più rilevante nella malattia di Alzheimer ad esordio tardivo, ha un impatto negativo sulla produzione di esosomi, sia negli esosomi derivati dal cervello umano, sia nel modello murino umanizzato che esprime l'allele ApoE4. Uno dei bersagli dell'apolipoproteina E è la proteina 8 correlata al recettore delle lipoproteine a bassa densità (LRP8 o ApoER2), altamente espressa nel tessuto neuronale e attivamente coinvolta nella formazione della memoria e nella modellazione dei dendriti. Considerando che in precedenza abbiamo osservato che la localizzazione e l'elaborazione di LRP8 sono alterate nella corteccia cerebrale di pazienti affetti da Alzheimer sporadico e familiare, abbiamo deciso di analizzare il ruolo dell'LRP8 sulla produzione di esosomi. Abbiamo riscontrato che negli esosomi derivati dal cervello di pazienti affetti da Alzheimer sporadico e familiare (SAD e FAD), sono fortemente presenti frammenti C-terminali del recettore LRP8 con peso molecolare inferiore a 15 kDa, che invece non sono evidenti nei controlli; segno che il processo proteolitico di LRP8 è fortemente alterato in caso di malattia e che il contenuto delle vescicole cambia radicalmente. Anche la produzione di esosomi cambia radicalmente, essendo fortemente compromessa nel caso di FAD. Abbiamo eseguito esperimenti in vitro utilizzando cellule wild-type Neuro 2A, trasfettate stabilmente con il recettore umano LRP8 (hLRP8) (Neuro 2A DDK myc e Neuro 2A LRP8 HA) e abbiamo scoperto che l'espressione del recettore LRP8 aumenta significativamente la produzione di esosomi. Abbiamo anche espresso nelle cellule Neuro 2A wild-type, la proteina umana Amyloid Precursor Protein 695 (hAPP 695), e abbiamo osservato che i frammenti C-terminali LRP8 sono presenti sia nei lisati cellulari che negli esosomi. Abbiamo evidenziato che il trattamento con ApoE4 umano ricombinante e DAPT (un inibitore della γ-secretasi) diminuisce la produzione di esosomi in vitro e che il trattamento con ApoE4 aumenta i frammenti C-terminali di LRP8 negli esosomi. Infine, per confermare che il recettore LRP8 è coinvolto nella produzione di esosomi, abbiamo eseguito un silenziamento sul recettore LRP8 utilizzando le cellule wild-type Neuro 2A. Abbiamo osservato che silenziando l'espressione di LRP8, c'è una significativa riduzione del numero di esosomi prodotti.
An increasing number of evidences has revealed that alterations of endosomal–lysosomal system are connected to alterated sorting and trafficking of different proteins, leading to a significant alteration of protein homeostasis itself. These alterations result particularly compromising in the field of neurodegenerative diseases. In this scenario, exosomes, extracellular vesicles derived from endosomal– lysosomal system, reflecting the alterations present in the cells that produced them, have attracted the attention of the scientific community, as possible early markers of disease. In the field of Alzheimer Disease, exosomes have been shown the capacity to reduce brain Amyloid-beta involving microglial uptake, and negative effects as spreading hyperphosphorylated tau, therefore they could be involved in the mechanisms of apoptosis and, ultimately, contribute to dendritic degeneration. Apolipoprotein E4 expression, the most relevant factor in Late Onset Alzheimer Disease, has a negative impact on exosomes production, both in human brain derived exosomes, and in humanized mouse model expressing ApoE4 allele. One of the target of Apolipoprotein E is Low-density lipoprotein Receptor-related Protein 8 (LRP8 or ApoER2), highly expressed in neuronal tissue and actively involved in memory formation and spines dendridic modeling. Considering that we previously observed that LRP8 localization and processing are alterated in the cerebral cortex of sporadic and familial Alzheimer’s Disease patients, we decided to analyze the role LRP8 on exosomes production. We found that in exosomes derived from brain of patients affected by sporadic and familial Alzheimer (SAD and FAD), C-terminal fragments of the LRP8 receptor with molecular weight less than 15 kDa are strongly present, which instead are not evident in controls; a sign that the proteolytic processing of LRP8 is strongly altered in case of disease and that the contents of the vesicles change radically. The production of exosomes also changes radically, being strongly compromised in the case of FAD. We performed in-vitro experiments using Neuro 2A wild-type cells, stably transfected with human LRP8 (hLRP8) receptor (Neuro 2A DDK myc and Neuro 2A LRP8 HA), and we found that LRP8 receptor expression significantly increases exosomes production. We also expressed in Neuro 2A wild-type cells, the human protein Amyloid Precursor Protein 695 (hAPP 695), and we observed that LRP8 C-terminal fragments are present both in the cell lysates and in the exosomes. We also reported that recombinant human ApoE4 and DAPT (a γ-Secretase inihibitor) treatment, decrease exosomes production in-vitro, and that ApoE4 treatment increase LRP8 C-terminal fragments in exosomes. Finally, to confirm that LRP8 receptor is involved in exosomes production, we performed a silencing on the LRP8 receptor using the Neuro 2A wild- type cells. We observed that silencing the expression of LRP8, there is a significant reduction in the number of exosomes produced.
APA, Harvard, Vancouver, ISO, and other styles
9

MELAZZINI, LUCA. "IMAGING BIOMARKERS OF CEREBRAL SMALL VESSEL DISEASE IN ADULTS WITH CONGENITAL HEART DISEASE." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/805883.

Full text
Abstract:
Aim Imaging biomarkers in medical fields other than oncology tend to be confined to research settings. In neuroimaging, biomarkers of cerebral small vessel disease (SVD) have shown promising results for translation into the clinic but need further validation. In this work, we strove for a more clinically-oriented classification of one of the most representative of SVD biomarkers, i.e. white matter hyperintensities (WMHs), on a large cohort of community-dwelling subjects. We also used this classification to better analyse signs of SVD in a selected population of adults with congenital heart disease. Lastly, we evaluated the steps to be taken for achieving standardisation of WMH assessment. Cerebral small vessel disease in adults with tetralogy of Fallot: preliminary results In this section we describe our exploratory research on a small sample of 10 adult patients with surgically corrected tetralogy of Fallot and 10 age- and sex-matched control subjects. Cerebral microbleeds were visible in every patient and in one control subject. Also, a significant correlation between WMH volume and severity of symptoms of heart failure was observed. Even though the aetiology of the observed findings remained obscure, cerebral microbleeds and WMHs may indicate an increased susceptibility to brain microvascular damage in congenital heart disease and have been deemed worthy of further investigations. Imaging biomarkers of small vessel disease in adults with congenital heart disease: a systematic review Considering our preliminary findings, we extensively reviewed the available literature on vascular injury in adults with congenital heart disease. We found few preliminary studies on this topic, all of which carried several methodological limitations. However, all studies reported a variety of brain vascular changes in the examined patients, ranging from signs of SVD to silent stroke and cortical atrophy. The assumption that these findings differ from those visible in children with heart defects needs to be confirmed. For this purpose, neuroimaging studies in adults with congenital heart disease are needed to differentiate past global lesion burden from present chronic ongoing cerebrovascular disease. Automatic sub-classification of white matter hyperintensities: application to a large community-dwelling cohort As WMH total volume is variably associated with cognition, we developed an automatic method to classify them into four categories according to lesion location (periventricular versus deep) and lesion intensity in T1 and T2-weighted sequences. We applied this method on brain scans from 684 older adults from the Whitehall II study. We also showed that periventricular white matter hyperintensities that appear hypointense in T1-weighted images were significantly associated with poorer performance in several cognitive tests in this cohort. Interestingly, we found no association between total WMH volume and cognition. These findings suggest that sub-classifying WMHs according to both location and intensity in T1-weighted images provides added value when studying the clinical correlates of this imaging biomarker. Inconsistency in quantifying and reporting white matter hyperintensities volume: a systematic review We tried to estimate a normative range for WMH volume in healthy ageing using the highest level of evidence. We meta-analysed 2743 healthy subjects’ WMH volume reported from 17 studies. Our results showed an extremely high heterogeneity across the examined studies. We thereby proposed methodological strategies needed to overcome the current inconsistency in WMH assessment, such as harmonisation of image acquisition and standardisation of anatomical definitions. Most importantly, effective communication between researchers and clinicians is strongly warranted to translate technical know-how for imaging biomarkers assessment into clinical practice. The BACH Study In view of our preliminary results and considering the dearth of scientific evidence on the topic of brain involvement in adults with congenital heart disease, we launched the Brain Aging in Congenital Heart disease (BACH) San Donato study. This multidisciplinary study comprises an extensive brain imaging protocol to investigate signs of small vessel disease and a thorough neuropsychological battery to test patients’ cognitive performance. We found that automatically-detected white matter hyperintensities located in the deep white matter were associated with poorer performance at the frontal assessment battery. Also, this study confirmed that patients had a much larger number of cerebral microbleeds than healthy controls. Conclusions In this thesis we showed that cerebral microbleeds are over-expressed in adult patients with congenital heart disease. Longitudinal studies will aid in clarifying the role of this and other biomarkers of SVD in predicting clinical outcomes. Meanwhile, much effort must be put into reaching standardisation of WMH assessment. Optimal characterisation of brain vascular health in congenital heart disease would enable physicians to adopt prompt strategies to prevent the risk of cognitive deterioration in this category of patients. Full translation of research findings into clinical practice would then be achieved.
APA, Harvard, Vancouver, ISO, and other styles
10

Fällmar, David. "­­­Visual assessment of perfusion and metabolism in neurodegenerative dementia." Doctoral thesis, Uppsala universitet, Radiologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-304731.

Full text
Abstract:
A worldwide demographic shift is currently occurring, with rapidly increasing numbers of elderly individuals. Since the incidence of neurodegenerative disease generally increases with age, this entails an increase in dementia prevalence. There are several strong incentives for establishing robust and widely available imaging methods for the early diagnosis of these diseases. Atrophy patterns are evident only late in the disease process, and the distinction from healthy ageing can often be elusive. For early diagnosis, physiologic parameters such as perfusion or metabolism must be assessed. The available modalities all have restricted clinical usefulness. The main aim of this thesis was to advance the clinical usefulness of perfusion and metabolism imaging in patients with neurodegenerative dementia, with a focus on visual assessment. A cohort of patients with neurodegenerative dementia was included, along with an age-matched control group. All subjects underwent MRI, including a pseudocontinuous ASL sequence and FDG-PET. In papers II and III, a subgroup containing both patients and controls underwent a second FDG-PET with reduced dose. In paper IV, the material was combined with a similar cohort from Amsterdam. Paper I showed that spatial smoothing increased the correlation between visually assessed perfusion and metabolism levels as displayed with FDG-PET. However, the distinction between patients and healthy controls was less satisfactory due to false positives. Paper II showed that differences in regional standard uptake value ratios between normal- and low-dose FDG-PET were small and without clinically significant bias. Paper III showed that the diagnostic performance of Z-score maps showing regions of significant deficits in metabolism was highly similar in normal- and low-dose FDG-PET images.  Paper IV showed that ASL perfusion-based Z-score maps can be used for diagnostic purposes with high specificity, but inferior sensitivity, compared to FDG-PET. In conclusion, the included studies address aspects of the visual assessment of perfusion and metabolism neuroimaging, with a focus on clinical usefulness in diagnosing neurodegenerative dementia.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Books on the topic "Neuroradiologia"

1

Ertl-Wagner, Birgit. Pädiatrische Neuroradiologie. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-68508-1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Goyal, Swati. Neuroradiology. First edition. | Boca Raton, FL : CRC Press, 2020.: CRC Press, 2020. http://dx.doi.org/10.1201/9780367903206.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

G, Ramsey Ruth, ed. Neuroradiology. 2nd ed. Philadelphia: Saunders, 1987.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
4

Neuroradiology. 3rd ed. Philadelphia: Saunders, 1994.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
5

C, Harwood-Nash Derek, and Pettersson Holger 1942-, eds. Neuroradiology. London: Merit Communications, 1992.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
6

Pantaleo, Romanelli, and Mazumdar Avi, eds. Neuroradiology. New York: McGraw-Hill, 2007.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
7

1919-, Taveras Juan M., ed. Neuroradiology. 3rd ed. Baltimore: Williams & Wilkins, 1996.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
8

Castillo, Mauricio. Neuroradiology. Philadelphia, PA: Lippincott Williams & Wilkins, 2003.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
9

Castillo, Mauricio. Neuroradiology. Philadelphia: Lippincott Williams & Wilkins, 2002.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
10

Wiesmann, Martin, Jennifer Linn, and Hartmut Brückmann, eds. Atlas Klinische Neuroradiologie. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-38109-6.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Book chapters on the topic "Neuroradiologia"

1

Ciceri, Elisa, and Luca Valvassori. "Principi di neuroradiologia intervenzionale." In Terapia delle malattie neurologiche, 555–67. Milano: Springer Milan, 2009. http://dx.doi.org/10.1007/978-88-470-1120-5_43.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Gallo, A., and G. Tedeschi. "Neuroradiologia e sclerosi multipla." In I disturbi neuropsichiatrici nella sclerosi multipla, 33–56. Milano: Springer Milan, 2011. http://dx.doi.org/10.1007/978-88-470-1711-5_2.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Bradac, Gianni Boris, Andrea Boghi, Marina Corsico, Maria Federica Ferrio, Paola Caroppo, and Mario Coriasco. "Applicazioni cliniche della RM in neuroradiologia." In Elementi di risonanza magnetica, 183–226. Milano: Springer Milan, 2014. http://dx.doi.org/10.1007/978-88-470-5641-1_7.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Bravo-Rodriguez, F., and Rocio Diaz-Aguilera. "Neuroradiologia e imaging di testa e collo." In Imaging diagnostico, 153–77. Milano: Springer Milan, 2009. http://dx.doi.org/10.1007/978-88-470-1510-4_7.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Alfke, Karsten, and Olav Jansen. "Neuroradiologie." In NeuroIntensiv, 25–35. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-46500-4_3.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Jansen, O., and A. Mohr. "Neuroradiologie." In Neurologische Intensivmedizin, 183–98. Berlin, Heidelberg: Springer Berlin Heidelberg, 1999. http://dx.doi.org/10.1007/978-3-642-58415-2_9.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Alfke, K., and O. Jansen. "Neuroradiologie." In NeuroIntensiv, 23–34. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-16911-3_3.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Weissleder, Ralph, Mark J. Rieumont, and Jack Wittenberg. "Neuroradiologie." In Kompendium der bildgebenden Diagnostik, 387–464. Vienna: Springer Vienna, 2003. http://dx.doi.org/10.1007/978-3-7091-6069-5_6.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Malhotra, Ajay. "Neuroradiology." In Vascular Neurology Board Review, 203–15. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-52552-1_16.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Babar, Judith, Oğuz Dicle, Hildo J. Lamb, Laura Oleaga, and Fermín Sáez. "Neuroradiology." In EDiR - The Essential Guide, 159–81. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-20066-4_9.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Neuroradiologia"

1

Drescher, F., V. Maus, W. Weber, and S. Fischer. "Neuroradiologie." In 101. Deutscher Röntgenkongress und 9. Gemeinsamer Kongress der DRG und ÖRG. © Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0040-1703491.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

"Clinical: Neuroradiology." In Proceedings of UK Radiological Conference 2015. The British Institute of Radiology, 2015. http://dx.doi.org/10.1259/conf-pukrc.2015.neuro.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

"Clinical: Neuroradiology." In Proceedings of UK Radiological Conference 2013. The British Institute of Radiology, 2013. http://dx.doi.org/10.1259/conf-pukrc.2013.neuro.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

"Clinical: Neuroradiology." In Proceedings of UK Radiological Conference 2014. The British Institute of Radiology, 2014. http://dx.doi.org/10.1259/conf-pukrc.2014.neuro.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

"Clinical: Neuroradiology." In Proceedings of UK Radiological Conference 2012. The British Institute of Radiology, 2012. http://dx.doi.org/10.1259/conf-pukrc.2012.7.neuro.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Lou, Shyhliang A., Robert B. Lufkin, Daniel J. Valentino, H. K. Huang, William Hanafee, Bradly Jabour, John R. Bentsen, Gary R. Duckwiler, and Jacques E. Dion. "Neuroradiology viewing station." In Medical Imaging '90, Newport Beach, 4-9 Feb 90, edited by Yongmin Kim. SPIE, 1990. http://dx.doi.org/10.1117/12.18861.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Close, Robert A., Gary R. Duckwiler, Fernando Vinuela, Jacques E. Dion, and Joshua Abramowitz. "Neuroradiology therapeutic workstation." In Medical Imaging '90, Newport Beach, 4-9 Feb 90, edited by Murray H. Loew. SPIE, 1990. http://dx.doi.org/10.1117/12.18927.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

"Head, Neck and Neuroradiology." In Proceedings of UK Radiological Conference 2016. The British Institute of Radiology, 2016. http://dx.doi.org/10.1259/conf-pukrc.2016.head-neck-neuro.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

"Head, Neck and Neuroradiology." In Proceedings of UK Radiological Conference 2017. The British Institute of Radiology, 2017. http://dx.doi.org/10.1259/conf-pukrc.2017.head-neck-neuro.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Valentino, Daniel J., Vikas Bhushan, Sandra L. Johnson, and John R. Bentsen. "Designing diagnostic workstations for neuroradiology." In Medical Imaging 1995, edited by R. Gilbert Jost and Samuel J. Dwyer III. SPIE, 1995. http://dx.doi.org/10.1117/12.208792.

Full text
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Neuroradiologia' for particular source types:
Journal articles Dissertations / Theses Books
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography