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Journal articles on the topic 'Neurospecific markers'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Levchuk, L. A., N. A. Bokhan, and S. A. Ivanova. "Neurospecific Proteins as Transdiagnostic Markers of Affective Disorders." Нейрохимия 40, no. 1 (2023): 30–34. http://dx.doi.org/10.31857/s1027813323010119.

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Mental disorders have many differences in pathogenesis and clinical symptoms, however, they are characterized by general neurobiological processes that occur with a damage of nervous tissue, disturbance of blood-brain barrier, inclusion of autoimmune mechanisms, neurodegenerative processes and release of neurospecific proteins into the liquor and into the blood. We presented a review of current literature devoted to studies of the role of neurospecific proteins in the pathogenesis of affective disorders. Glial fibrillar acidic protein (GFAP), S-100 protein, myelin basic protein (MBP), and neur

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Panova, M. S., A. S. Panchenko, A. M. Ziganshin, and V. A. Mudrov. "Neurospecific markers of brain damage in infants." Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) 67, no. 5 (2022): 55–61. http://dx.doi.org/10.21508/1027-4065-2022-67-5-55-61.

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Timely diagnosis of brain lesions in infants is important for preventing the development and progression of neurological diseases.Purpose. The study aimed at investigation of neurospecific laboratory parameters in children of 1 year of age with structural changes in the brain.Material and methods. The clinical and laboratory examination of 50 children of 1 year of age, born at full term, was carried out. Serum concentrations of neurotrophic growth factor (BDNF), fractalkine (CX3CL-1), monocytic chemotactic protein (CCL2), trigger receptor expressed on myeloid cells-1, 2 (TREM-1, TREM-2), trans

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Zhukova, I. A., V. M. Alifirova, and N. G. Zhukova. "Neurospecific enolase as a nonspecific neurodegenerative process marker." Bulletin of Siberian Medicine 10, no. 2 (2011): 15–21. http://dx.doi.org/10.20538/1682-0363-2011-2-15-21.

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For the diagnosis and prognosis of various diseases is essential to determine specific markers in blood serum. Neuronspecific enolase (NSE) is a common marker of differentiatedneurons. The aim of the study was to evaluate the activity of NSE in patients with Parkinson's disease (PD) and chronic cerebral ischemia. The study results showed that the activity of NSE varied dependingon sex and age in PD patients, the stage and rate of progression of disease, age debut and severity of cognitive impairment. Thus, determination of NSE in the serum of PD patients should be included in the complex exami

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Stepanova, T. V., E. B. Popyhova, and A. N. Ivanov. "LABORATORY INDICATORS OF DIABETIC POLYNEUROPATHY." Medical academic journal 19, no. 1S (2019): 112–14. http://dx.doi.org/10.17816/maj191s1112-114.

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This study is devoted to diabetic polyneuropathy (DPN) - one of the common complications of diabetes mellitus (DM). The possibilities of laboratory diagnosis of this condition are shown. The purpose of this study was to examine the pathogenetic and diagnostic significance of certain neurospecific proteins and cytokines in DPN. The analysis of the literature data on the possibility of using neurospecific proteins and some cytokines in patients with diabetes as markers of neural tissue damage has been carried out.

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Levchuk, L. A., N. A. Bokhan, and S. A. Ivanova. "Neurospecific Proteins as Transdiagnostic Markers of Affective Disorders." Neurochemical Journal 17, no. 1 (2023): 25–29. http://dx.doi.org/10.1134/s1819712423010117.

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Samoylova, Yulia Gennad'evna, Maria Vladimirovna Novoselova, Natalya Grigor'evna Zhukova, and Olga Sergeevna Tonkikh. "Analysis of the Role of Neurospecific Proteins in the Diagnosis of Cognitive Dysfunction in Patients with Type 1 Diabetes Mellitus." Diabetes mellitus 17, no. 2 (2014): 83–90. http://dx.doi.org/10.14341/dm2014283-90.

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Background. Impairment of the central nervous system manifested as cognitive dysfunction caused by metabolic or structural changes is a severe progressive vascular complication of type 1 diabetes mellitus (T1DM). Significant difficulties in the diagnosis of cognitive dysfunction are associated with subjective diagnostic techniques. Objective. To identify the role of neurospecific markers in the diagnosis of cognitive dysfunction in patients with T1DM. Materials and Methods. A total of 58 patients with T1DM aged 16?30 years were included in this study. The control group included 29 healthy youn

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Karkashadze, George A., Leyla S. Namazova-Baranova, Leonid M. Yatsik, et al. "Levels of Neurospecific Peptides, Neurotransmitters and Neuroreceptor Markers in the Serum of Children with Various Sensory Disorders, Mild Cognitive Impairments and Other Neuropathology." Pediatric pharmacology 19, no. 6 (2023): 459–78. http://dx.doi.org/10.15690/pf.v19i6.2486.

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Background. The role of recently discovered neurospecific peptides in the pathogenesis of acute and progressive neurologic disorders, their neuroprotective features, and possibilities to use them as markers for the course and prognosis of certain diseases have been actively studied in recent decades. However, neurospecific peptides are almost not studied in chronic residual diseases. In our study we measured the levels of neurospecific peptides and some other markers to achieve understanding of general neurophysiological trends in congenital and acquired chronic non-progressive brain pathology

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BYKOV, YU V., and A. A. MURAVYOVA. "LABORATORY BIOMARKERS FOR BRAIN DAMAGE IN DIABETES MELLITUS." AVICENNA BULLETIN 25, no. 3 (2023): 370–79. http://dx.doi.org/10.25005/2074-0581-2023-25-3-370-379.

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Objective: This review outlines the literature data on the main laboratory biomarkers of brain damage in diabetes mellitus (DM) type I and II. Neurospecific proteins: S-100 protein, neurospecific enolase, glial fibrillar acidic protein, myelin basic protein, and brain-derived neurotrophic factor (BDNF) are considered specific markers of cerebral dysfunction in DM. Emphasis is placed on pro-inflammatory cytokines (IL-1, IL-6, tumor necrosis factor-α, C-reactive protein), as blood biomarkers, the increase of which indicates brain damage in DM type I and II. High concentrations of adipokines, inf

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Poluliakh, O. E., T. A. Mityukova, A. I. Martynenko, O. V. Zakharevich, and S. A. Marchuk. "Development of the concepts of childhood autism: pathogenetic mechanisms and markers." Proceedings of the National Academy of Sciences of Belarus, Medical series 16, no. 4 (2019): 499–512. http://dx.doi.org/10.29235/1814-6023-2019-16-4-499-512.

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Today, the study of autism spectrum disorders is relevant due to a high prevalence, an increase in the frequency of occurrence, as well as due to a lack of the unified concept of their etiology and pathogenesis. The purpose of the work is to conduct a brief review of evolution of the childhood autism ideas, including the pathogenesis issues and a search for possible markers of this disease. A brief information on the historical development of the childhood autism ideas, from the pre-Kanner period until now is presented. The modern pathogenesis theories are considered, including heredity, as we

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Samoĭlova, Iu G., M. V. Novoselova, A. K. Kostiunina, É. D. Pirmagomedova, and A. V. Latypov. "Predictors of the development of encephalopathy in the patients presenting with diabetes mellitus." Problems of Endocrinology 59, no. 5 (2013): 67–71. http://dx.doi.org/10.14341/probl201359567-71.

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The present review encompasses the data from the Russian-language and foreign publications. Diabetes mellitus (DM) is currently considered to be a global socio-medical, psychological, and economic problem due to the high frequency of vascular complications resulting in early invalidization of the patients. Encephalopathy (EP) is one of the most severe complications of DM leading to the substantial deterioration of the quality of life. Both the markers and the diagnostic criteria of EP remain to be determined. Certain neurospecific proteins are believed to be predictors of this pathology.

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KURAKINA, A. S., N. A. SHCHELCHKOVA, I. V. MUKHINA, and V. N. GRIGORYEVA. "Diagnostics value of neurospecific proteins in patients with meningiomas." Practical medicine 18, no. 5 (2020): 16–20. http://dx.doi.org/10.32000/2072-1757-2020-5-16-20.

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The purpose was to study the diagnostic value of the content of brain-derived neurotrophic factor (BDNF) and glial-derived neurotrophic factor (GDNF) in patients with meningiomas before and after surgery. Material and methods. The study involved 70 patients with meningiomas and 62 healthy people. The examination of the patients included clinical and neurological examination, determination of BDNF and GDNF (R&D Systems, USA) content in blood plasma using enzyme immunoassay performed before the surgery and 5–6 days after meningioma surgery. The totality of meningioma removal was determined i

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Roschina, O. V., L. A. Levchuk, G. G. Simutkin, S. A. Ivanova, and N. A. Bokhan. "Relationship of Neurospecific Serum Proteins with Clinical Features in Depressive Episode and Recurrent Depressive Disorder." Psikhiatriya 21, no. 4 (2023): 42–48. http://dx.doi.org/10.30629/2618-6667-2023-21-4-42-48.

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Background: depressive disorders remain an important medical problem and present significant economic and social burden on the health care system. This sets the task for the scientific community to increase the level of their detection, treatment and prevention. It seems promising to study the role of markers of neuronal disorders, in particular, proteins S-100, MBP, GFAP, in the pathogenesis of primary and recurrent depressive disorders.Purpose of the study: to determine the relationship between clinical and psychopathological characteristics of depressive disorders (anxiety, depression, aggr

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Boklazhenko, Elena V., and Galina M. Bodienkova. "Comparative assessment of neurotrophic proteins in vibration disease." Hygiene and sanitation 103, no. 9 (2024): 954–58. http://dx.doi.org/10.47470/0016-9900-2024-103-9-954-958.

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Introduction. The problem of health impairment due to the impact of physical factors, including vibration disease (VD), retains medical and social relevance due to the significant specific gravity in the structure of occupational morbidity and high prevalence. Under vibration exposure, the acid-base equilibrium, immune status are disturbed, rheological properties and properties of the neurohumoral system, as well as functional indices of the central and peripheral nervous system change. Neurotrophins are known to play an important role in regulating the development and functioning of the centr

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Melentev, Andrey V., and Oleg A. Oshkoderov. "Assessment of the diagnostic significance of modern biomarkers and hemodynamic alterations in workers of vibration-hazardous occupations." HEALTH CARE OF THE RUSSIAN FEDERATION 65, no. 4 (2021): 379–83. http://dx.doi.org/10.47470/0044-197x-2021-65-4-379-383.

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Introduction. One of the most significant tasks in modern labor medicine is to reduce the indicators of early disability in persons in contact with harmful and dangerous factors of the production environment. The issue of finding markers of early preclinical manifestations of vibrational disease and establishing comorbid conditions that are prognostically unfavorable for the course of the underlying occupational disease remains relevant. The purpose of the study is assessment of diagnostic significance of current neurospecific biomarkers and hemodynamic changes in workers of the profession rel

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Zelenenko, Maria A., Valeria A. Pechatnikova, Vassiliy A. Zaplutanov, et al. "Cerebral damage pathogeny peculiarities in local and globalcerebral perfusion impairment models in rats." Pediatrician (St. Petersburg) 8, no. 6 (2017): 62–71. http://dx.doi.org/10.17816/ped8662-71.

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A complex study of clinical and laboratory pathogenic features of cerebrovascular disease has been performed in rats using two experimental models: local ischemia with cerebral infarction and global ischemia caused by acute or chronic impairment of cerebral circulation without verified site of brain damage. A pronounced difference has been demonstrated between the two studied models of cerebral impairment. The development of brain damage site constituting 20-30% of the total cortex of the impaired hemisphere was demonstrated to be accompanied by a considerable increase of basic nervous tissue

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Rodynskyi, O., K. Basysta, and L. Guz. "Neurochemical and behavioral processes in gerontogenesis in conditions of experimental hyperglycemia." Medicni perspektivi 23, no. 2 (2018): 4–13. https://doi.org/10.26641/2307-0404.2018.2.133691.

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Many researchers are increasingly interested in the relation between diabetes and diabetic encephalopathy. At the moment, there are various experiments where this issue is considered. But despite prolonged studying, it is impossible to investigate this problem to the end. Cognitive deficit in hyperglycemia is also connected with aging. In the aging processes as in hyperglycemia the same pathogenetic factors play a role in the aging of the brain. It is also necessary to deeply analyze the neurochemical processes occurring in the brain in diabetes mellitus. The high incidence of complications is

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Corsetti, Veronica, Carla Perrone-Capano, Michael Sebastian Salazar Intriago, et al. "Expression of Cholinergic Markers and Characterization of Splice Variants during Ontogenesis of Rat Dorsal Root Ganglia Neurons." International Journal of Molecular Sciences 22, no. 11 (2021): 5499. http://dx.doi.org/10.3390/ijms22115499.

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Dorsal root ganglia (DRG) neurons synthesize acetylcholine (ACh), in addition to their peptidergic nature. They also release ACh and are cholinoceptive, as they express cholinergic receptors. During gangliogenesis, ACh plays an important role in neuronal differentiation, modulating neuritic outgrowth and neurospecific gene expression. Starting from these data, we studied the expression of choline acetyltransferase (ChAT) and vesicular ACh transporter (VAChT) expression in rat DRG neurons. ChAT and VAChT genes are arranged in a “cholinergic locus”, and several splice variants have been describe

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Morgun, A. V., N. V. Ovcharenko, T. E. Taranushenko, et al. "MARKERS OF APOPTOSIS AND NEUROSPECIFIC PROTEINS IN THE DIAGNOSIS OF PERINATAL LESIONS OF CENTRAL NERVOUS SYSTEM IN NEWBORNS." Siberian Medical Review, no. 3 (2013): 3–11. http://dx.doi.org/10.20333/25000136-2013-3-3-11.

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19

Kuzmin, E. A., Z. V. Shamitko, G. A. Piavchenko, A. A. Venediktov, M. Yu Ivanova, and S. L. Kuznetsov. "Biomarkers of neuroinflammation in the diagnosis of traumatic brain injury and neurodegenerative diseases: a literature review." Sechenov Medical Journal 15, no. 1 (2024): 20–35. http://dx.doi.org/10.47093/2218-7332.2024.15.1.20-35.

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Inflammatory processes accompanied by damage to the cell bodies of neurons are combined into the group of neuroinflammation. At the molecular, cellular and tissue levels, neuroinflammation serves as a sanogenetic response to a variety of injuries, including post-traumatic conditions and neurodegeneration. However, inflammatory changes in long-lived cells such as neurons inevitably trigger a range of adverse effects. As a result, prognosis often depends on the severity of neuroinflammation. In this work, we review the spectrum of biomarkers involved in two key mechanisms of neuroinflammation: i

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Strokova, E. L., N. Yu Pakhomova, A. I. Shevchenko, A. A. Korytkin, V. V. Kozhevnikov, and А. M. Zaidman. "Phenotypic features of rib cartilage cells in funnel-shaped chest deformity." Сибирский научный медицинский журнал 43, no. 6 (2024): 203–9. http://dx.doi.org/10.18699/ssmj20230625.

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Funnel-shaped deformity of the chest is a serious disease with an unknown etiology and pathogenesis. Pathological changes occurring in the cartilaginous tissue of the ribs are one of the leading mechanisms for the development of chest curvature. Analysis of the phenotypic features of cells isolated from the site of localization of the pathological process will create a more complete picture of the deformation development.Aim of the study was to identify the phenotype of rib cartilage cells in funnel-shaped deformation of the thorax.Material and methods. Rib cartilage cells of children with fun

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Abdul-Khaliq, Hashim, Stephan Schubert, Gisela Stoltenburg-Didinger, et al. "Release patterns of astrocytic and neuronal biochemical markers in serum during and after experimental settings of cardiac surgery." Restorative Neurology and Neuroscience 21, no. 3-4 (2003): 141–50. https://doi.org/10.3233/rnn-2003-00233.

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Objective: Brain injury and altered psychomotor development in infants, children and adults after cardiac surgery using cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA) is still a matter of concern. Early diagnosis and identification of brain injury that has occurred or is ongoing by measurement of biochemical markers in serum may have diagnostic and prognostic value. The aim of the experimental studies in an animal model was therefore to investigate the release patterns of astroglial and neuronal markers in serum and to determine the morphological and immunohistoche

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Levchuk, Lyudmila A., Olga V. Roschina, Ekaterina V. Mikhalitskaya, et al. "Serum Levels of S100B Protein and Myelin Basic Protein as a Potential Biomarkers of Recurrent Depressive Disorders." Journal of Personalized Medicine 13, no. 9 (2023): 1423. http://dx.doi.org/10.3390/jpm13091423.

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Nowadays, nervous tissue damage proteins in serum are considered promising drug targets and biomarkers of Mood Disorders. In a cross-sectional naturalistic study, the S100B, MBP and GFAP levels in the blood serum were compared between two diagnostic groups (patients with Depressive Episode (DE, n = 28) and patients with Recurrent Depressive Disorder (RDD, n = 21)), and healthy controls (n = 25). The diagnostic value of serum markers was assessed by ROC analysis. In the DE group, we did not find changed levels of S100B, MBP and GFAP compared with controls. In the RDD group, we found decreased S

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Цветикова, L. Tsvetikova, Бугримов, et al. "Severity of neurological deficiency in the children of early age by means of neurobiochemistry markers assessment." Journal of New Medical Technologies. eJournal 8, no. 1 (2014): 1–5. http://dx.doi.org/10.12737/4109.

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The true picture of the severity and the degree of central nervous system (CNS) in children of the first months of life, doesn&#180;t is always reflected. The outcome of the disease, including unfavorable, is obvious only to the 9-12 months of age due to the features that are assessed as the phenomena of self-defense. A lot of attention in modern Russian and foreign literature is given to the biochemical risk factors for the development of various diseases and their complications, in particular the indicators of oxidative stress, lipid peroxidation, oxidative modification of proteins and a

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Hårdemark, Hans-Göran, Nils Ericsson, Zbigniew Kotwica, et al. "S-100 protein and neuron-specific enolase in CSF after experimental traumatic or focal ischemic brain damage." Journal of Neurosurgery 71, no. 5 (1989): 727–31. http://dx.doi.org/10.3171/jns.1989.71.5.0727.

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✓ Cerebrospinal fluid (CSF) markers of brain damage are potentially capable of providing quantitative information about the extent of certain neurological injury. The presence of such markers in CSF after brain damage is transient and it is essential to understand their kinetics if they are to be used in clinical practice. In the present study, the CSF concentrations of two neurospecific proteins, S-100 protein and neuron-specific enolase (NSE), were determined in rats before and repeatedly after one of two types of experimental brain damage: traumatic cortical injury and focal cerebral ischem

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Muraviova, D. V., M. R. Buniatov, and G. A. Ushakovа. "Calcium-binding protein, S100b, in the blood as a biochemical marker of the neurological state of men in warzones." Regulatory Mechanisms in Biosystems 9, no. 4 (2018): 529–34. http://dx.doi.org/10.15421/021879.

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Acute and chronic stress are two of the most challenging issues faced by men situated in warzones. According to the main concept of G. Selye, stress response is the most important link during the adaptation of an organism to environmental factors. However, excessively intense or prolonged exposure to stress creates the threat of sustained homeostasis disorder. At present, the primary indicators in clinical studies are the general biochemical parameters of blood alanine aminotransferase, aspartate aminotransferase, bilirubin, creatine, urea, total protein, and glucose levels. But these indicato

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Khodak, T. V., V. O. Tykholaz, and V. M. Shevchenko. "Postnatal neurogenesis in the neuroproliferative areas of the brain." Reports of Vinnytsia National Medical University 26, no. 4 (2022): 676–80. http://dx.doi.org/10.31393/reports-vnmedical-2022-26(4)-27.

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Annotation. The purpose of the work is to systematize and analyze existing problematic aspects in the study of postnatal neurogenesis in neuroproliferative areas of the brain. The relevance of this problem is due to the growing share of neurodegenerative diseases and the search for the possibility of their treatment. From the databases PubMed, ScienceDirect, UpToDate, Web of science, Scopus, 28 sources on this problem were selected for consideration, regardless of age, with a predominance of publications from the last 10 years. The state of research related to the study of postnatal neurogenes

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Taskina, E. S., I. V. Kibalina, V. A. Mudrov, and S. O. Davydov. "Cerebral markers of neuroinflammation and neurodegeneration in hypertensive disorders during pregnancy." Medical Immunology (Russia) 27, no. 4 (2025): 713–22. https://doi.org/10.15789/1563-0625-cmo-3169.

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Preeclampsia/eclampsia during pregnancy and postpartum are the major risk factors for maternal and infant morbidity and mortality worldwide. At the same time, more than 70% of maternal deaths are of neurological origin, i.e., eclampsia, cerebral edema, intracranial hemorrhage and stroke. Generalized endothelial dysfunction caused by placental antiangiogenic factors leads to increased permeability of the blood-brain barrier and impaired autoregulation of cerebral circulation. Previous studies have shown that preeclampsia increases the risk of cerebrovascular and cardiovascular diseases, as well

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Shponka, I. S., V. I. Popovych, О. М. Usova, O. O. Bondarenko, Yu V. Haman, and H. Z. Shchuruk. "Morphological features of changes in peripheral olfactory structures in SARS-COV-2 coronavirus infection." Pathologia 18, no. 3 (2021): 278–85. http://dx.doi.org/10.14739/2310-1237.2021.3.234369.

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Coronavirus infection caused by the SARS-CoV-2 virus is an extremely important and urgent problem of modern medicine. It spreads quickly, has a high probability of a severe course and a large number of critical complications in patients from the risk group. The presence of pathognomonic symptoms, one of which is the development of hypo– or anosmia, makes it possible to quickly differentiate coronavirus infection from other acute respiratory viral infections, that is, to isolate the patient on time and begin correct treatment, taking all possible risks into account. The aim is to identify the m

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Bykov, Yuri V. "Диагностика когнитивной дисфункции при сахарном диабете 1-го типа в детском возрасте (обзор)". Journal of Medical and Biological Research, № 3 (20 вересня 2024): 399–410. http://dx.doi.org/10.37482/2687-1491-z199.

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Type 1 diabetes mellitus (DM) is a common childhood endocrinopathy that can present with cognitive dysfunction (CD). PubMed, Cochrane Library, eLIBRARY.RU and Medscape databases were searched for Englishand Russian-language articles published from 2010 to 2023 using the following keywords: type 1 diabetes mellitus, children, cognitive dysfunction and diagnosis. Publications on CD in adult patients with type 1 DM were excluded from this review. In children with DM, the aetiology of CD is multifactorial and has the following confirmed risk factors: acute hypoglycaemia, chronic hyperglycaemia, ea

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Корелина, В. Е., И. Р. Газизова, Ю. И. Рожко, and Е. П. Гончарук. "Markers of Neuroinflammation in Patients with Primary Open-Angle Glaucoma: Review." Офтальмология. Восточная Европа 14, no. 2 (2024): 292–301. http://dx.doi.org/10.34883/pi.2024.14.2.027.

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В статье обсуждаются возможности диагностики глаукомы с помощью глиальных биомаркеров. Клетки нейроглии играют ключевую роль в развитии нейровоспаления при глаукоме. Определение активности глиальных клеток сетчатки поможет выявлять специфические биомаркеры начинающегося глаукомного процесса. Среди биохимических маркеров нейровоспаления активно исследуют нейроспецифические белки. Авторы анализируют имеющиеся данные о глиальных белках, используемых в лабораторной диагностике. Протеин S100 – наиболее изученный и уже используемый в лабораторной диагностике глиальный биомаркер. При глаукоме отмечаю

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Volkova, Y. V., S. S. Dubivska, A. V. Omelchenko-Seliukova, and O. V. Biletskyi. "Dynamics of neurospecific autoimmune disorders and cognitive functions in patients with polytrauma and alcohol withdrawal syndrome complicated by alcohol delirium." Reports of Vinnytsia National Medical University 25, no. 4 (2021): 605–9. http://dx.doi.org/10.31393/reports-vnmedical-2021-25(4)-16.

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Annotation. Polytrauma is considered the main cause of death among people younger 45 years. Among trauma patiens 15-20% regularly take alcohol, close to 32% of patients who needed intensive therapy to alcohol withdrawal syndrome (AWS), and 5-20% of the progressed to alcohol delirium. The aim of the study is to analyze the dynamics of autoimmune response to markers of neurodestruction in the blood of patients with moderate polytrauma and alcohol withdrawal, complicated by alcohol delirium and assessment of cognitive functions depending on the method of sedation. The study involved 80 patients w

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Ivkin, Artyom A., Evgeny V. Grigoriev, Dmitry G. Balakhnin, and Alyona A. Mikhailova. "USE OF POSTOPERATIVE KETAMINE INFUSION FOR CEREBRAL PROTECTION IN CHILDREN IN CARDIAC SURGERY." Complex Issues of Cardiovascular Diseases 13, no. 3S (2024): 98–109. https://doi.org/10.17802/2306-1278-2024-13-3s-98-109.

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HighlightsThe presented study is relevant due to high incidence of cognitive impairment during cardiac surgery in children. The article describes and proves the effectiveness of a cerebral protection strategy using ketamine infusion in subanesthetic doses. AbstractAim. To assess the effectiveness of ketamine infusion in the postoperative period for neuroprotection in children during surgical correction of congenital septal heart defects.Methods. The study included 68 patients aged from 1 to 60 months and weighing from 3.9 to 19.5 kg who underwent correction of atrial or ventricular septal defe

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Simonov, A. N., T. P. Klyushnik, L. V. Androsova, and T. P. Safarova. "Predicting the Risk of Depression in the Elderly by Immunological Indicators Research." Psikhiatriya 18, no. 4 (2020): 26–32. http://dx.doi.org/10.30629/2618-6667-2020-18-4-26-32.

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Objective: to construct a mathematical model that predicts the state of depression by immunological parameters in the blood plasma of older people to further predict the development of the disease.Patients and methods: 55 hospitalized patients of late age (mean age 69.2 ± 6.9 years) with a depressive episode were included in the study. The control group consisted of 41 elderly people (average age 66.6 ± 6.2 years) without depressive disorders. The activity of inflammatory and autoimmune markers in the blood plasma of patients and control groups was determined: the enzymatic activity of leukocy

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Ruchkin, M. P., E. V. Markelova, G. A. Fedyashev, and V. N. Yuschyuk. "Role of cytokines, neuropeptids and matrix metalloproteinases in the immunopathogenesis of retinal neurodegeneration in diabetic retinopathy." Russian Journal of Immunology 25, no. 4 (2022): 515–20. http://dx.doi.org/10.46235/1028-7221-1157-roc.

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Currently, diabetic retinopathy (DR) is considered both a vascular lesion, as well as a neurodegenerative disease. The normal functioning of the glia and retinal neurons depends on the balance between the cytokine system, neurotrophic factors and matrix metalloproteinases. The disorders that occur in these systems are assigned an important role in many neurodegenerative processes. The purpose of the present study was to determine the levels of IL-1, IL-17A, TNF, IFN, IL-10, TGF-1, TGF-2, TGF-3, MMP- 2, MMP-7, MMP-9, TIMP-1, TIMP-2, S100b protein, BDNF and NGF in the serum of patients with type

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Мовсумов, В. З., and Л. П. Смертина. "CORRELATION OF THE S100B PROTEIN AND THE DEGREE OF COGNITIVE IMPAIRMENTS IN PATIENTS WITH HIV INFECTION." Vestnik SurGU. Meditsina 16, no. 1 (2023): 74–76. http://dx.doi.org/10.35266/2304-9448-2023-1-74-76.

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The study aims to investigate the relation between cognitive impairments and neurospecific S100β protein in HIV patients. The quantitative content of the neurospecific S100β protein in the blood of 20 patients with HIV infection was determined using the Montreal scale (MoCa test). In all cases, HIV patients with cognitive impairment had an elevated level of S100β, while in some cases, patients with an increased level of the S100β protein did not suffer from cognitive decline. S100β may be a marker of central nervous system damage causing cognitive decline, but it is not clear whether elevated

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NIKITINA, E. A., and V. A. NOVIKOV. "Role of neuron-specific enolase in the pathogenesis of hypoxic-ischemic encephalopathy in newborns." Practical medicine 20, no. 5 (2022): 29–33. http://dx.doi.org/10.32000/2072-1757-2022-5-29-33.

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The literature data on the clinical and diagnostic significance of neuron-specific enolase in the development of hypoxic-ischemic encephalopathy in newborns are presented. The expediency of determining this marker in various variants of the disease course is shown. The study of the content of this neurospecific protein is valuable for diagnosing, monitoring and predicting the course and outcomes of hypoxic-ischemic encephalopathy.

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Serikova, I. Yu, G. I. Shumacher, E. N. Vorobyova, I. A. Batanina, and R. I. Vorobyov. "Clinical and biochemical predictors of neurological disorders." Medical alphabet 4, no. 35 (2020): 34–39. http://dx.doi.org/10.33667/2078-5631-2019-4-35(410)-34-39.

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The aim of this study is to identify clinical and biochemical predictors of neurological disorders in adolescents who have suffered mild perinatal damage of the central nervous system. We examined 120 adolescents (62 girls and 58 boys) aged 13–16 years, who were hospitalized in the city Children’s Neurological Department. It was found that adolescents with perinatal lesions of the central nervous system, activated lipid peroxidation processes and revealed an increase in the concentration of protein S 100, which in the future could lead to the development of neurodegeneration processes. In addi

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Rubina, S. S., L. V. Chichanovskaia, I. I. Makarova, A. A. Yusufov, and N. N. Slyusar. "Relationship of neurospecific proteins with neuroimaging and cognitive disorders in patients with obstructive sleep apnea." Meditsinskiy sovet = Medical Council, no. 5 (May 10, 2024): 98–106. http://dx.doi.org/10.21518/ms2024-172.

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Aim. To evaluate the relationship of neurospecific proteins with neuroimaging and cognitive impairment in patients with OSA.Materials and methods. 65 patients were examined. Two groups of patients were distinguished: the main group – with moderate and severe OSA, the control group – without OSA. The subjects underwent anthropometry, polysomnography, magnetic resonance imaging of the brain (MRI GM), assessment of cognitive impairment. Glial fibrillar acidic protein (GFAP), antibodies to the NR2 subunit of NMDA (AT to GRIN2A), and brain-derived neurotrophic factor (BDNF) were studied by enzyme i

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Deyneko, M. O. "Dynamics of neurospecific enolase as a leading marker in determining the functional state of the blood-brain barrier in patients with metabolic coma." Reports of Vinnytsia National Medical University 24, no. 4 (2020): 670–74. http://dx.doi.org/10.31393/reports-vnmedical-2020-24(4)-19.

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Annotation. Determining the pathogenetic mechanism of disturbance of consciousness, coma, at the stage of admission of the patient to the intensive care unit is an important point in determining the features of the algorithm of treatment of such patients. The aim of this study was to determine the mechanisms of the primary cause of loss of consciousness (coma) in the acute period of its course and to assess the effectiveness of pathogenetically sound intensive care since the patient's admission to the clinic. We examined 60 patients with coma of neurotropic metabolic (secondary) origin, who we

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Klimenko, L. L., A. V. Skalny, A. I. Deev, et al. "THE CONCENTRATION OF NEUROSPECIFIC PROTEINS S100, MAGNESIUM AND TRACE ELEMENTS IN BLOOD SERUM AS A DIAGNOSTIC MARKER OF ISCHEMIC STROKE: A CLINICAL STUDY." Trace Elements in Medicine (Moscow) 20, no. 3 (2019): 31–37. http://dx.doi.org/10.19112/2413-6174-2019-20-3-31-37.

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Kamilov, Halidjan, Munirahon Kasimova, and Dilbar Makhkamova. "LEVEL OF MARKERS OF NEURODEGENERATION IN PATIENTS WITH OCULAR ISCHEMIC SYNDROME." European Medical, Health and Pharmaceutical Journal 7, no. 2 (2014). http://dx.doi.org/10.12955/emhpj.v7i2.522.

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The purpose of this study was to investigate the content neurospecific markers protein S-100 and neuroenolaza in blood serum and tear fluid of patients with ocular ischemic syndrome.Material and methods. We observed 43 patients aged 57 to 79 years, mean age 67.3 ± 2.7 years. Control group consisted of 11 volunteers without ophthalmic symptoms. The main group consisted of 32 patients with OIS. The neurospecific proteins S100 and NSE were investigated in blood serum and tear fluid.Results. The study found that in patients of the control group the content of protein were within the normal range:

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Urmanova, Yu, and A. Holikov. "“CHANGES IN THE NERVOUS SYSTEM IN PATIENTS WITH DIABETES MELLITUS TYPE 2 WITH NEPHROPATHY AND PROGNOSTIC SIGNIFICANCE OF NEUROMARKERS OF BRAIN INJURY. LITERATURE REVIEW"." EurasianUnionScientists, September 14, 2021, 3–8. http://dx.doi.org/10.31618/esu.2413-9335.2021.1.89.1437.

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THE PURPOSE OF THE STUDY is to carry out an analysis of the literature evaluating diabetic encephalopathy by determining neuromarkers. MATERIAL AND METHODS. In this article, the authors analyzed the literature on the role of neuromarkers in patients with type 2 diabetes mellitus undergoing program hemodialysis. RESEARCH RESULTS. Among biochemical markers, the determination of the level of neurospecific proteins is actively being investigated. The main part of them is autoantigens, entering the bloodstream, can cause the appearance of autoantibodies, which, when the blood-brain barr

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Urmanova, Yu, and A. Holikov. "“CHANGES IN THE NERVOUS SYSTEM IN PATIENTS WITH DIABETES MELLITUS TYPE 2 WITH NEPHROPATHY AND PROGNOSTIC SIGNIFICANCE OF NEUROMARKERS OF BRAIN INJURY. LITERATURE REVIEW"." EurasianUnionScientists, September 14, 2021, 3–8. http://dx.doi.org/10.31618/esu.2413-9335.2021.1.89.1437.

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THE PURPOSE OF THE STUDY is to carry out an analysis of the literature evaluating diabetic encephalopathy by determining neuromarkers. MATERIAL AND METHODS. In this article, the authors analyzed the literature on the role of neuromarkers in patients with type 2 diabetes mellitus undergoing program hemodialysis. RESEARCH RESULTS. Among biochemical markers, the determination of the level of neurospecific proteins is actively being investigated. The main part of them is autoantigens, entering the bloodstream, can cause the appearance of autoantibodies, which, when the blood-brain barr

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Bodienkova, G. M., and E. V. Boklazhenko. "Patterns of changes in certain neurospecific proteins in patients with post-contact period chronic mercury intoxication." Нейрохимия 41, no. 1 (2024). http://dx.doi.org/10.31857/s1027813324010102.

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The aim of the study was to identify patterns of change in certain neurospecific proteins (BDNF, S100β, MBP) in the serum of patients with chronic mercury intoxication (CMI) after stopping exposure to the toxicant. In clinical conditions, men with an established diagnosis of chronic mercury intoxication were examined in a distant period after isolation from a toxicant in chemical production. Serum concentrations of neurospecific proteins (BDNF, S100β, MBP) were determined by solid-phase enzyme-linked immunosorbent assay using a commercial test-systems of ChemiKine (USA), CanAg (Sweden) and Ans

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Choi, Yuri, Jae Hyun Park, Ala Jo, et al. "Blood-derived APLP1 ⁺ extracellular vesicles are potential biomarkers for the early diagnosis of brain diseases." Science Advances 11, no. 1 (2025). https://doi.org/10.1126/sciadv.ado6894.

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The early detection of neurodegenerative diseases necessitates the identification of specific brain-derived biomolecules in peripheral blood. In this context, our investigation delineates the role of amyloid precursor-like protein 1 (APLP1)—a protein predominantly localized in oligodendrocytes and neurons—as a previously unidentified biomarker in extracellular vesicles (EVs). Through rigorous analysis, APLP1 + EVs from human sera were unequivocally determined to be of cerebral origin. This assertion was corroborated by distinctive small RNA expression patterns of APLP1 + EVs. The miRNAs’ putat

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Клименко, Л. Л. "Биохимические механизмы транзиторной ишемической атаки". Асимметрия 17, № 4 (2023). https://doi.org/10.25692/asy.2023.17.4.002.

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Проведено сравнение этиопатогенеза двух диагностически близких патологий – ишемического инсульта и транзиторной ишемической атаки (ТИА). Выявлено концентрационное различие макро- и микроэлементов и нейроспецифических белков в сыворотке крови при этих заболеваниях, что свидетельствует о глубоком различии их этиопатогенеза. Этот факт является основанием для возможности дифференциальной диагностики ишемического инсульта и транзиторной ишемической атаки с помощью микроэлементного анализа. Результаты исследования свидетельствуют о том, что для пациентов с цереброваскулярными заболеваниями характерн

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Ziablitsev, S. V., O. O. Starodubska, and O. O. Diadyk. "Influence of carbacetam on neurologic destruction processes under the experimental traumatic brain injury." February 27, 2017. https://doi.org/10.5281/zenodo.583749.

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Ziablitsev S. V., Starodubska O. O., Diadyk O. O. Influence of carbacetam on neurologic destruction processes under the experimental traumatic brain injury. Journal of Education, Health and Sport. 2017;7(2):601-611. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.583749 http://ojs.ukw.edu.pl/index.php/johs/article/view/4496 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2017; This article is published with open access at Licensee O

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Mussack, Thomas, Josef Briegel, Gustav Schelling, Peter Biberthaler, and Marianne Jochum. "Effect of stress doses of hydrocortisone on S-100B vs. interleukin-8 and polymorphonuclear elastase levels in human septic shock." Clinical Chemistry and Laboratory Medicine (CCLM) 43, no. 3 (2005). http://dx.doi.org/10.1515/cclm.2005.044.

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AbstractStress doses of hydrocortisone are known to have immunomodulatory effects in patients with hyperdynamic septic shock. The prognosis correlates with the presence and severity of septic encephalopathy. However, neurological evaluation is influenced by the use of analgesia sedation during artificial ventilation. The objective of this study was to demonstrate the effect of stress doses of hydrocortisone during the initial phase of human septic shock on the serum values of the neurospecific protein S-100B in comparison to the inflammation markers interleukin (IL)-8 in serum and polymorphonu

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Mavrutenkov, V. V., N. V. Zhukova, and L. O. Kravchuk. "The level of S100b protein in blood serum of patients with hiv/tb co-infectoin as a neurospecific biomarker of neurotoxicity." Medical and Clinical Chemistry 17, no. 2 (2015). http://dx.doi.org/10.11603/mcch.2410-681x.2015.v17.i2.4864.

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There was studied the influence of antiretroviral and antimycobacterial chemotherapy on releasing from the glia<br />cell marker lesions – S100b protein in the context of possible iatrogenic. It was established that a slight increase in<br />the concentration of S100b protein in blood serum of patients with co-infection of HIV /TB after starting HAART was<br />not associated with the occurrence of symptoms of the central nervous system.

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