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Journal articles on the topic 'Neurotherapeutic effect'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Binjhade, Neha, Vinanti Supare, Shailesh Ghaywat, Sagar Trivedi, Kamlesh Wadher, and Milind Umekar. "Agmatine: A potential Neurotherapeutic Agent." Journal of Drug Delivery and Therapeutics 11, no. 4 (2021): 88–92. http://dx.doi.org/10.22270/jddt.v11i4.4855.

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Agmatine, a natural polyamine disregarded almost for over 100 years, was discovered in year 1910. Almost after a decade, several researches on Agmatine indicated its modulatory action at multiple molecular targets such as, nitric oxide synthesis, neurotransmitter systems, and polyamine metabolism unbolt the new avenues for extensive therapeutic applications which includes neurotrauma and neurodegenerative diseases, antidepressant, cognitive disorders. Agmatine exerts its varied biological characteristics and therapeutic potential in diverse arena. Agmatine has been extensively researched for i

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Abeer, A. A. Salama, and M. M. Ibrahim Bassant. "Neurotherapeutic effect of allopurinol against brain injury in hyperlipidemic rats." African Journal of Pharmacy and Pharmacology 9, no. 22 (2015): 567–75. http://dx.doi.org/10.5897/ajpp2014.4247.

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Lv, Xiu-li, Yi Wang, Bing Hu, Le Kang, Jun Xin, and Guo-Ying Zhang. "Neurotherapeutic effect of mangiferin against hypoxic–ischemic encephalopathy in neonatal rats." African Journal of Traditional, Complementary and Alternative Medicines 13, no. 2 (2016): 229. http://dx.doi.org/10.4314/ajtcam.v13i2.27.

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Lv, Xiu-li, Yi Wang, Bing Hu, Le Kang, Jun Xin, and Guo-Ying Zhang. "NEUROTHERAPEUTIC EFFECT OF MANGIFERIN AGAINST HYPOXIC–ISCHEMIC ENCEPHALOPATHY IN NEONATAL RATS." African Journal of Traditional, Complementary and Alternative Medicines 13, no. 2 (2016): 229–36. http://dx.doi.org/10.21010/ajtcam.v13i2.27.

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Background: Hypoxic–ischemic encephalopathy (HIE) in perinatal condition is highly associated with mortality and several neurological disabilities. The present experiment was blueprinted to ascertain the protective efficacy of mangiferin (MF) against hypoxic–ischemic brain injury in neonatal rats.  Materials and methods: Fourth six neonatal rats (pubs) were arbitrarily separated into four groups as a sham group that received only water (control; n=12), pubs exposed to Hypoxic–ischemic (HI) insult (HI group-II; n=11), pubs receiving 20 (MF 20+HI-III; n=11) or 40 (MF 40+HI-IV; n=12) mg/kg

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Zeng, Xiang, Alexander E. Ropper, Zaid Aljuboori, et al. "Concurrent Oncolysis and Neurolesion Repair by Dual Gene-Engineered hNSCs in an Experimental Model of Intraspinal Cord Glioblastoma." Cells 13, no. 18 (2024): 1522. http://dx.doi.org/10.3390/cells13181522.

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Intramedullary spinal cord glioblastoma (ISCG) is lethal due to lack of effective treatment. We previously established a rat C6-ISCG model and the antitumor effect of F3.CD-TK, an hNSC line expressing CD and TK, via producing cytocidal 5FU and GCV-TP. However, the neurotherapeutic potential of this hNSC approach has remained uninvestigated. Here for the first time, cultured F3.CD-TK cells were found to have a markedly higher oncolytic effect, which was GJIC-dependent, and BDNF expression but less VEGF secretion than F3.CD. In Rowett athymic rats, F3.CD-TK (1.5 × 106 cells/10 µL × 2), injected

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Dr., W.M.D.S. Perera, H.A.R.P. Perera Dr., and Vidhyajini R.V. "Neuro-therapeutic effect of Rauvolfia serpentina (Sarpagandha/ Ekaweriya); A review." Journal of Advances in Experimental Therapeutics and Neurotherapeutics 1, no. 2 (2023): 7–12. https://doi.org/10.5281/zenodo.8085009.

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<em>Sarpagandha </em><em>is a popular</em><em> and rich compendium of herbs of Ayurveda and is botanically identified as </em><em>Rauvolfia serpentina</em><em>. It is extensively used in the management of neurological disorders. It possesses active principles belonging to Alkaloids, Phenols, F</em><em>lavonoids, and Tan</em><em>n</em><em>ins. </em><em>Relevant authentic Ayurveda texts and English language articles from databases PubMed, Research Gate and Google Scholar were searched using appropriate keywords and following the PRISMA model Present review work emphasizes the neurotherapeutic ef

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Vázquez Alberdi, Lucia, Gonzalo Rosso, Lucía Velóz, et al. "Curcumin and Ethanol Effects in Trembler-J Schwann Cell Culture." Biomolecules 12, no. 4 (2022): 515. http://dx.doi.org/10.3390/biom12040515.

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Charcot-Marie-Tooth (CMT) syndrome is the most common progressive human motor and sensory peripheral neuropathy. CMT type 1E is a demyelinating neuropathy affecting Schwann cells due to peripheral-myelin-protein-22 (PMP22) mutations, modelized by Trembler-J mice. Curcumin, a natural polyphenol compound obtained from turmeric (Curcuma longa), exhibits dose- and time-varying antitumor, antioxidant and neuroprotective properties, however, the neurotherapeutic actions of curcumin remain elusive. Here, we propose curcumin as a possible natural treatment capable of enhancing cellular detoxification

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BULAMA, Ibrahim, Nasiru SULEİMAN, Lawal BİLBİS, et al. "Antioxidative and Neurotherapeutic Effect of Ascorbic acid on Albino rats Induced with Traumatic Brain Injury." Journal of Cellular Neuroscience and Oxidative Stress 12, no. 1 (2020): 922–36. http://dx.doi.org/10.37212/jcnos.800233.

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Arien-Zakay, Hadar, Galit Gincberg, Arnon Nagler, et al. "Neurotherapeutic Effect of Cord Blood Derived CD45+Hematopoietic Cells in Mice after Traumatic Brain Injury." Journal of Neurotrauma 31, no. 16 (2014): 1405–16. http://dx.doi.org/10.1089/neu.2013.3270.

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Ahmad, Mohammad, Homood Alharbi, Abdualrahman Saeed Alshehry, and Ahmed Alsadoun. "Comparative Evaluation of the Ameliorating Effects of Some Natural Products as Neurotherapeutic Interventions for a Neurodegenerative Disorder in Status Epilepticus Model." Annals of Neurodegenerative Disorders 8, no. 1 (2024): 1–9. http://dx.doi.org/10.47739/neurodegenerativedisorders1035.

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Background: The lithium-pilocarpine (Li-Pc) model of status epilepticus (SE) is the most convenient and is frequently used for pathophysiological and management strategies in search of new, safe, and effective therapeutic agents including natural remedies for SE. Oral administration of cinnamon (CIN), Nigella sativa (NS), and curcumin (CUR) can reduce neuroinflammation which is a common feature of neurodegenerative disorders. Although many studies on CUR and NS effects on SE have been undertaken, to our best knowledge no study has been conducted on studying the effect of CIN on SE. Purpose: Th

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Hong, Jin Young, Hyunseong Kim, Junseon Lee, Wan-Jin Jeon, Seung Ho Baek, and In-Hyuk Ha. "Neurotherapeutic Effect of Inula britannica var. Chinensis against H2O2-Induced Oxidative Stress and Mitochondrial Dysfunction in Cortical Neurons." Antioxidants 10, no. 3 (2021): 375. http://dx.doi.org/10.3390/antiox10030375.

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Inula britannica var. chinensis (IBC) has been used as a traditional medicinal herb to treat inflammatory diseases. Although its anti-inflammatory and anti-oxidative effects have been reported, whether IBC exerts neuroprotective effects and the related mechanisms in cortical neurons remain unknown. In this study, we investigated the effects of different concentrations of IBC extract (5, 10, and 20 µg/mL) on cortical neurons using a hydrogen peroxide (H2O2)-induced injury model. Our results demonstrate that IBC can effectively enhance neuronal viability under in vitro-modeled reaction oxygen sp

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Renukadevi J, Rithikha S, Yokesh S, and Karthikha VS. "Neurotherapeutic Potential of Resveratrol: A Comprehensive Review of Its Neuroprotective Mechanisms in Mitigating Cognitive Decline." International Research Journal of Multidisciplinary Scope 05, no. 04 (2024): 775–83. http://dx.doi.org/10.47857/irjms.2024.v05i04.01397.

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Cognitive decline is a term used to refer to the decline in neurocognitive development of a person hence the loss of language skills, memory, or executive functions. The new directions in the prevention of cognitive impairment involve the consumption of phytonutrient-dense diets. To some extent this review aims to understand the impact of resveratrol in inhibition of neuro inflammation involved in cognitive impairment. To conduct a population, intervention, comparison, outcome and time tissue search was performed with an emphasis on gathering preclinical studies and clinical research on the mo

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Kang, Mi-Sun, Gil-Hyun Lee, Go-Eun Choi, Hae-Gyung Yoon, and Kyung-Yae Hyun. "Neuroprotective Effect of Nypa fruticans Wurmb by Suppressing TRPV1 Following Sciatic Nerve Crush Injury in a Rat." Nutrients 12, no. 9 (2020): 2618. http://dx.doi.org/10.3390/nu12092618.

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Peripheral nerve injury can result in severe functional impairment and decreased quality of life due to loss of sensory and motor function. Nypa fruticans wurmb (NF) has been used in diverse folk remedies in East Asia. We have previously shown that Nypa fruticans wurmb extract has antinociceptive and anti-inflammatory effects by suppressing TRPV1 in the sciatic nerve injury. The present study investigated the effects of NF on the control of TRPV1 in relation to neuroprotective effects of a sciatic nerve crush injury. To evaluate the neuroprotective effects, an animal behavior test and a physio

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Kim, Hyunseong, Jin Young Hong, Junseon Lee, Wan-Jin Jeon, and In-Hyuk Ha. "Apamin Enhances Neurite Outgrowth and Regeneration after Laceration Injury in Cortical Neurons." Toxins 13, no. 9 (2021): 603. http://dx.doi.org/10.3390/toxins13090603.

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Apamin is a minor component of bee venom and is a polypeptide with 18 amino acid residues. Although apamin is considered a neurotoxic compound that blocks the potassium channel, its neuroprotective effects on neurons have been recently reported. However, there is little information about the underlying mechanism and very little is known regarding the toxicological characterization of other compounds in bee venom. Here, cultured mature cortical neurons were treated with bee venom components, including apamin, phospholipase A2, and the main component, melittin. Melittin and phospholipase A2 from

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Prokai-Tatrai, Katalin, Daniel L. De La Cruz, Vien Nguyen, Benjamin P. Ross, Istvan Toth, and Laszlo Prokai. "Brain Delivery of Thyrotropin-Releasing Hormone via a Novel Prodrug Approach." Pharmaceutics 11, no. 7 (2019): 349. http://dx.doi.org/10.3390/pharmaceutics11070349.

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Using thyrotropin-releasing hormone (TRH) as a model, we explored whether synergistic combination of lipoamino acid(s) and a linker cleaved by prolyl oligopeptidase (POP) can be used as a promoiety for prodrug design for the preferential brain delivery of the peptide. A representative prodrug based on this design principle was synthesized, and its membrane affinity and in vitro metabolic stability, with or without the presence of a POP inhibitor, were studied. The in vivo formation of TRH from the prodrug construct was probed by utilizing the antidepressant effect of the peptide, as well as it

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El-Baz, Farouk K., Abeer Salama, and Rania A. A. Salama. "Dunaliella salina Attenuates Diabetic Neuropathy Induced by STZ in Rats: Involvement of Thioredoxin." BioMed Research International 2020 (January 8, 2020): 1–11. http://dx.doi.org/10.1155/2020/1295492.

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Diabetic neuropathy (DN) is a widespread disabling disorder including peripheral nerves’ damage. The aim of the current study was to estimate the potential ameliorative effect of Dunaliella salina (D. salina) on DN and the involvement of the thioredoxin. Diabetes was induced by streptozotocin (STZ; 50 mg/kg; i.p). Glimepiride (0.5 mg/kg) or D. salina powder (100 or 200 mg/kg) were given orally, after 2 days of STZ injection for 4 weeks. Glucose, total antioxidant capacity (TAC), superoxide dismutase (SOD), and catalase (CAT) serum levels as well as brain contents of thioredoxin (Trx), tumor ne

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Ramburrun, Poornima, Pradeep Kumar, Yahya E. Choonara, Divya Bijukumar, Lisa C. du Toit, and Viness Pillay. "A Review of Bioactive Release from Nerve Conduits as a Neurotherapeutic Strategy for Neuronal Growth in Peripheral Nerve Injury." BioMed Research International 2014 (2014): 1–19. http://dx.doi.org/10.1155/2014/132350.

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Peripheral nerve regeneration strategies employ the use of polymeric engineered nerve conduits encompassed with components of a delivery system. This allows for the controlled and sustained release of neurotrophic growth factors for the enhancement of the innate regenerative capacity of the injured nerves. This review article focuses on the delivery of neurotrophic factors (NTFs) and the importance of the parameters that control release kinetics in the delivery of optimal quantities of NTFs for improved therapeutic effect and prevention of dose dumping. Studies utilizing various controlled-rel

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Farida, Siti, Desak G. B. Krisnamurti, Ninik Mudjihartini, Erni H. Purwaningsih, Imelda M. Sianipar, and Lisnawati Lisnawati. "The combination of Acalypha indica–Centella asiatica extracts decreases the neuronal damage in hypoxia-induced hippocampal injury animal model." Medical Journal of Indonesia 27, no. 3 (2018): 137–44. http://dx.doi.org/10.13181/mji.v27i3.1697.

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Background: Approximately 80–85% of strokes are ischemic and lead to alterations in neuronal cell morphology and cell death. There is a lack of studies on the effect of the combination of Acalypha indica L. (AI) and Centella asiatica L. (CA) in terms of its neurotherapy property. This study was conducted to investigate the neurotherapeutic effect of the combination of AI–CA extracts in improving rat’s hippocampal neuron injury post-hypoxia.Methods: A total of 36 Sprague-Dawley rats were categorized into six groups and placed in a hypoxia chamber for 7 consecutive days. Then, they were moved to

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Gincberg, Galit, Esther Shohami, Philip Lazarovici, and Uriel Elchalal. "Human Umbilical Cord Blood CD45+ Pan-Hematopoietic Cells Induced a Neurotherapeutic Effect in Mice with Traumatic Brain Injury: Immunophenotyping, Comparison of Maternal and Neonatal Parameters, and Immunomodulation." Journal of Molecular Neuroscience 64, no. 2 (2017): 185–99. http://dx.doi.org/10.1007/s12031-017-1008-8.

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Eddin, Lujain Bader, Niraj Kumar Jha, M. F. Nagoor Meeran, Kavindra Kumar Kesari, Rami Beiram, and Shreesh Ojha. "Neuroprotective Potential of Limonene and Limonene Containing Natural Products." Molecules 26, no. 15 (2021): 4535. http://dx.doi.org/10.3390/molecules26154535.

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Limonene is a monoterpene confined to the family of Rutaceae, showing several biological properties such as antioxidant, anti-inflammatory, anticancer, antinociceptive and gastroprotective characteristics. Recently, there is notable interest in investigating the pharmacological effects of limonene in various chronic diseases due to its mitigating effect on oxidative stress and inflammation and regulating apoptotic cell death. There are several available studies demonstrating the neuroprotective role of limonene in neurodegenerative diseases, including Alzheimer’s disease, multiple sclerosis, e

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Gincberg, Galit, Esther Shohami, Victoria Trembovler, Alexander G. Alexandrovich, Philip Lazarovici, and Uriel Elchalal. "Nerve growth factor plays a role in the neurotherapeutic effect of a CD45 + pan-hematopoietic subpopulation derived from human umbilical cord blood in a traumatic brain injury model." Cytotherapy 20, no. 2 (2018): 245–61. http://dx.doi.org/10.1016/j.jcyt.2017.11.008.

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Dzięgielewski, Piotr, Emilia Mikołajewska, and Aleksander Goch. "Hyperbaric oxygen therapy in post-stroke patients." Journal of Education, Health and Sport 5, no. 8 (2015): 302–6. https://doi.org/10.5281/zenodo.28813.

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<strong>Dzięgielewski Piotr, Mikołajewska Emilia, Goch Aleksander. </strong><strong>Hyperbaric oxygen therapy in post-stroke patients. </strong><strong>Journal</strong> <strong>of</strong> <strong>Education</strong><strong>, </strong><strong>Health</strong> <strong>and</strong> <strong>Sport</strong><strong>. </strong><strong>2015;5(8):</strong><strong>302</strong><strong>-</strong><strong>306</strong><strong>.</strong> <strong>ISSN</strong><strong> 2391-8306</strong><strong>. </strong><strong>DOI</strong> <strong>10.5281/zenodo.28813</strong> <strong>http://dx.doi.org/10.5281/zenodo.28813</st

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Rubia, Katya, Samuel Westwood, Pascal-M. Aggensteiner, and Daniel Brandeis. "Neurotherapeutics for Attention Deficit/Hyperactivity Disorder (ADHD): A Review." Cells 10, no. 8 (2021): 2156. http://dx.doi.org/10.3390/cells10082156.

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This review focuses on the evidence for neurotherapeutics for attention deficit/hyperactivity disorder (ADHD). EEG-neurofeedback has been tested for about 45 years, with the latest meta-analyses of randomised controlled trials (RCT) showing small/medium effects compared to non-active controls only. Three small studies piloted neurofeedback of frontal activations in ADHD using functional magnetic resonance imaging or near-infrared spectroscopy, finding no superior effects over control conditions. Brain stimulation has been applied to ADHD using mostly repetitive transcranial magnetic and direct

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Rasool, Rabia, Inam Ullah, Samiah Shahid, et al. "In Vivo Assessment of the Ameliorative Impact of Some Medicinal Plant Extracts on Lipopolysaccharide-Induced Multiple Sclerosis in Wistar Rats." Molecules 27, no. 5 (2022): 1608. http://dx.doi.org/10.3390/molecules27051608.

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Multiple sclerosis is a chronic autoimmune disorder that leads to the demyelination of nerve fibers, which is the major cause of non-traumatic disability all around the world. Herbal plants Nepeta hindustana L., Vitex negundo L., and Argemone albiflora L., in addition to anti-inflammatory and anti-oxidative effects, have shown great potential as neuroprotective agents. The study was aimed to develop a neuroprotective model to study the effectiveness of herbal plants (N. hindustana, V. negundo, and A. albiflora) against multiple sclerosis. The in vivo neuroprotective effects of ethanolic extrac

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Efrati, Shai, and Eshel Ben-Jacob. "Reflections on the neurotherapeutic effects of hyperbaric oxygen." Expert Review of Neurotherapeutics 14, no. 3 (2014): 233–36. http://dx.doi.org/10.1586/14737175.2014.884928.

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Mahan, Vicki L. "Neuroprotective, neurotherapeutic, and neurometabolic effects of carbon monoxide." Medical Gas Research 2, no. 1 (2012): 32. http://dx.doi.org/10.1186/2045-9912-2-32.

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Božičević, Lucija, Valerije Vrček, Nikolina Peranić, Nikolina Kalčec, and Ivana Vinković Vrček. "Nanoplastics increase in vitro oestrogenic activity of neurotherapeutic drugs." Archives of Industrial Hygiene and Toxicology 75, no. 1 (2024): 68–75. http://dx.doi.org/10.2478/aiht-2024-75-3818.

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Abstract Environmental pollution with plastic nanoparticles (PNPs) has rendered hazard assessment of unintentional human exposure to neurotherapeutic drugs through contaminated water and food ever more complicated. Due to their small size, PNPs can easily enter different cell types and cross different biological barriers, while their high surface-to-volume ratio enables higher adsorption of chemicals. This is how PNPs take the role of a Trojan horse as they enhance bioaccumulation of many different pollutants. One of the health concerns related to water pollution with neurotherapeutic drugs is

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Juul, Sandra E., Emily Voldal, Bryan A. Comstock, et al. "Association of High-Dose Erythropoietin With Circulating Biomarkers and Neurodevelopmental Outcomes Among Neonates With Hypoxic Ischemic Encephalopathy." JAMA Network Open 6, no. 7 (2023): e2322131. http://dx.doi.org/10.1001/jamanetworkopen.2023.22131.

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ImportanceThe ability to predict neurodevelopmental impairment (NDI) for infants diagnosed with hypoxic ischemic encephalopathy (HIE) is important for parental guidance and clinical treatment as well as for stratification of patients for future neurotherapeutic studies.ObjectivesTo examine the effect of erythropoietin on plasma inflammatory mediators in infants with moderate or severe HIE and to develop a panel of circulating biomarkers that improves the projection of 2-year NDI over and above the clinical data available at the time of birth.Design, Setting, and ParticipantsThis study is a pre

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Rubia, K. "Neuroimaging and neurotherapeutics for Attention Deficit Hyperactivity Disorder (ADHD)." ANALES RANM 138, no. 138(02) (2021): 124–31. http://dx.doi.org/10.32440/ar.2021.138.02.rev02.

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This paper reviews the functional magnetic resonance imaging (fMRI) literature of Attention Deficit Hyperactivity Disorder (ADHD) of the past three decades and the modern neurotherapies that have used these biomarkers as targets for treatment. Meta-analyses of task-based fMRI studies have shown functional abnormalities in different domain-dependent frontal, striatal, parietal, and cerebellar regions in ADHD. Resting state fMRI studies confirm abnormalities in different fronto-striato-parietal cognitive control, dorsal and ventral attention networks. The frontal parts of these networks have bee

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Tanzer, Lisa, and Kathryn J. Jones. "Neurotherapeutic action of testosterone on hamster facial nerve regeneration: temporal window of effects." Hormones and Behavior 45, no. 5 (2004): 339–44. http://dx.doi.org/10.1016/j.yhbeh.2004.01.002.

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Adams, Jose A., Arkady Uryash, Jorge Bassuk, Marvin A. Sackner, and Paul Kurlansky. "Biological basis of neuroprotection and neurotherapeutic effects of Whole Body Periodic Acceleration (pGz)." Medical Hypotheses 82, no. 6 (2014): 681–87. http://dx.doi.org/10.1016/j.mehy.2014.02.031.

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Rani, Priyanka, Shailja ., Balvinder Singh, and Pawan Jalwal. "Neurotherapeutic effects of Ganoderma lucidum: Biochemical characterization and behavioral assessment in animal models." Journal of Pharmacognosy and Phytochemistry 14, no. 3 (2025): 690–98. https://doi.org/10.22271/phyto.2025.v14.i3i.15426.

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Rahul, Dhangar Kusumakar Patil Chandrakant Pardeshi. "DIRECT NOSE TO BRAIN DELIVERY OF NEUROTHERAPEUTICS- LOADED NANOEMULSION." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 05 (2019): 9154–63. https://doi.org/10.5281/zenodo.2682528.

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<em>The blood–brain barrier (BBB) plays a fundamental role in protecting the brain from toxic substances and therefore also controls and restricts the entry of therapeutic agents. The nasal administration of drugs using the nose-to-brain pathway allows direct drug targeting into the brain, avoiding the first-pass effect and bypassing the BBB. Through the nasal route, the drug can access the brain directly along the trigeminal and olfactory nerves, which are located in the upper part of the nasal cavity. Nanoemulsions are formulations belonging to the field of nanomedicine. They consist o

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Cui, Weitong, Yuxi Zhan, Xiaoru Shao, et al. "Neuroprotective and Neurotherapeutic Effects of Tetrahedral Framework Nucleic Acids on Parkinson’s Disease in Vitro." ACS Applied Materials & Interfaces 11, no. 36 (2019): 32787–97. http://dx.doi.org/10.1021/acsami.9b10308.

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Rakha, M. K., R. A. Tawfiq, M. M. Sadek, et al. "Neurotherapeutic Effects of Bee Venom in a Rotenone-Induced Mouse Model of Parkinson’s Disease." Neurophysiology 50, no. 6 (2018): 445–55. http://dx.doi.org/10.1007/s11062-019-09777-w.

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Anukulthanakorn, Kanya, Ishwar S. Parhar, Sukanya Jaroenporn, Takashi Kitahashi, Gen Watanbe, and Suchinda Malaivijitnond. "Neurotherapeutic Effects of Pueraria mirifica Extract in Early- and Late-Stage Cognitive Impaired Rats." Phytotherapy Research 30, no. 6 (2016): 929–39. http://dx.doi.org/10.1002/ptr.5595.

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Akanchise, Thelma, and Angelina Angelova. "Ginkgo Biloba and Long COVID: In Vivo and In Vitro Models for the Evaluation of Nanotherapeutic Efficacy." Pharmaceutics 15, no. 5 (2023): 1562. http://dx.doi.org/10.3390/pharmaceutics15051562.

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Coronavirus infections are neuroinvasive and can provoke injury to the central nervous system (CNS) and long-term illness consequences. They may be associated with inflammatory processes due to cellular oxidative stress and an imbalanced antioxidant system. The ability of phytochemicals with antioxidant and anti-inflammatory activities, such as Ginkgo biloba, to alleviate neurological complications and brain tissue damage has attracted strong ongoing interest in the neurotherapeutic management of long COVID. Ginkgo biloba leaf extract (EGb) contains several bioactive ingredients, e.g., bilobal

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Sun, Min-Yu, Andrew J. Linsenbardt, Christine M. Emnett, et al. "24(S)-Hydroxycholesterol as a Modulator of Neuronal Signaling and Survival." Neuroscientist 22, no. 2 (2015): 132–44. http://dx.doi.org/10.1177/1073858414568122.

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The major cholesterol metabolite in brain, 24(S)-hydroxycholesterol (24S-HC), serves as a vehicle for cholesterol removal. Its effects on neuronal function, however, have only recently begun to be investigated. Here, we review that nascent work. Our own studies have demonstrated that 24S-HC has potent positive modulatory effects on N-methyl-d-aspartate (NMDA) receptor (NMDAR) function. This could have implications not only for brain plasticity but also for pathological NMDAR overuse. Other work has demonstrated effects of 24S-HC on neuronal survival and as a possible biomarker of neurodegenera

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Mitra, Saikat, Maniza Muni, Nusrat Jahan Shawon, et al. "Tacrine Derivatives in Neurological Disorders: Focus on Molecular Mechanisms and Neurotherapeutic Potential." Oxidative Medicine and Cellular Longevity 2022 (August 18, 2022): 1–22. http://dx.doi.org/10.1155/2022/7252882.

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Tacrine is a drug used in the treatment of Alzheimer’s disease as a cognitive enhancer and inhibitor of the enzyme acetylcholinesterase (AChE). However, its clinical application has been restricted due to its poor therapeutic efficacy and high prevalence of detrimental effects. An attempt was made to understand the molecular mechanisms that underlie tacrine and its analogues influence over neurotherapeutic activity by focusing on modulation of neurogenesis, neuroinflammation, endoplasmic reticulum stress, apoptosis, and regulatory role in gene and protein expression, energy metabolism, Ca2+ ho

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Mishra, Awanish, Pragya Shakti Mishra, Ritam Bandopadhyay, et al. "Neuroprotective Potential of Chrysin: Mechanistic Insights and Therapeutic Potential for Neurological Disorders." Molecules 26, no. 21 (2021): 6456. http://dx.doi.org/10.3390/molecules26216456.

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Chrysin, a herbal bioactive molecule, exerts a plethora of pharmacological effects, including anti-oxidant, anti-inflammatory, neuroprotective, and anti-cancer. A growing body of evidence has highlighted the emerging role of chrysin in a variety of neurological disorders, including Alzheimer’s and Parkinson’s disease, epilepsy, multiple sclerosis, ischemic stroke, traumatic brain injury, and brain tumors. Based on the results of recent pre-clinical studies and evidence from studies in humans, this review is focused on the molecular mechanisms underlying the neuroprotective effects of chrysin i

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Vlček, Přemysl, Jiri Horacek, Lippertová Marcela Grünerová, and Martin Brunovsky. "Therapeutic potential of acetyl-DL-leucine and its L-enantiomer in posterior fossa syndrome: Mechanistic insights." Drug Discovery Today 30, no. 6 (2025): 104389. https://doi.org/10.1016/j.drudis.2025.104389.

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Posterior fossa syndrome (PFS) is a serious postoperative complication that primarily affects children following resection of posterior fossa tumors. Although its complex pathophysiology, involving disruption of cerebellar structures and the dentato–thalamo-cortical pathway, is increasingly being elucidated, effective treatments remain limited. This perspective explores acetyl-DL-leucine (ADLL) and its active L-enantiomer, N-acetyl-L-leucine (NALL), as promising therapeutic candidates for PFS. Emerging mechanistic, preclinical, and clinical evidence suggests that both compounds might all

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Morris, Gerwyn, Basant K. Puri, Michael Maes, Lisa Olive, Michael Berk, and Andre F. Carvalho. "The role of microglia in neuroprogressive disorders: mechanisms and possible neurotherapeutic effects of induced ketosis." Progress in Neuro-Psychopharmacology and Biological Psychiatry 99 (April 2020): 109858. http://dx.doi.org/10.1016/j.pnpbp.2020.109858.

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Ling, Weiqi, Xu Xu, and Jinbo Liu. "A causal relationship between the neurotherapeutic effects of miR182/7a and decreased expression of PRDM5." Biochemical and Biophysical Research Communications 490, no. 1 (2017): 1–7. http://dx.doi.org/10.1016/j.bbrc.2017.05.141.

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Seema Sharma, Inderpreet Kaur, Rupinder Kaur, and Sampat Singh Tanwar. "Neuroprotective Effects of Berberine in Alzheimer's Disease." Journal of Pharma Insights and Research 3, no. 2 (2025): 337–45. https://doi.org/10.69613/7nf68287.

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Alzheimer's disease (AD) is one of the predominant causes of dementia worldwide. It is characterized by progressive neurodegeneration, cognitive decline, and distinctive neuropathological features including β-amyloid plaques and neurofibrillary tangles. Current therapeutic interventions provide only symptomatic relief, emphasizing the need for disease-modifying treatments. Berberine, an isoquinoline alkaloid derived from various medicinal plants, is being recognized as a promising treatment for AD treatment due to its diverse pharmacological properties. Recent studies have shown the berberine'

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Lucas, Kathryn, Molly King, Beatrice Ugiliweneza, and Andrea Behrman. "Durability of Improved Trunk Control Following Activity-Based Locomotor Training in Children With Acquired Spinal Cord Injuries." Topics in Spinal Cord Injury Rehabilitation 28, no. 1 (2022): 53–63. http://dx.doi.org/10.46292/sci21-00040.

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Background: A recent study in pediatric spinal cord injury (SCI) demonstrated activity-based locomotor training (ABLT) improved trunk control, measured by the Segmental Assessment of Trunk Control (SATCo). It is not known whether improved trunk control is maintained and, if so, for how long. Objectives: The purpose was to determine the durability of improvements in trunk control after ABLT is stopped. We hypothesized that SATCo scores at follow-up would not significantly regress (a) beyond the score measured at discharge and (b) to the initial SATCo pre-ABLT level. Methods: Patients were asses

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Pamela, Maher, Kipré Gueyraud Rolland, Bla Kouakou Brice, Offoumou M’Bai Rostand, Currais Antonio, and Djaman Allico Joseph. "Anti-Oxytotic/Ferroptotic Neuroprotection by Medicinal Plants from Côte d’Ivoire." East African Scholars Journal of Medical Sciences 7, no. 02 (2024): 18–27. http://dx.doi.org/10.36349/easms.2024.v07i02.001.

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Dementia in sub-Saharan Africa has been largely underestimated, but the cases are expected to increase substantially as African countries are experiencing highrates of growthin older people. As conventional medicine is expensive and often inaccessible, the majority of the communities in Africa rely on traditional medicine for basic health care. Plants may be a valuable source of neurotherapeutics, particularly of inhibitors of oxytosis/ferroptosis, a neurodegenerative pathway associated with dementia. This study evaluated the anti-oxytotic/ferroptotic activity of different plants used in the t

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Cheyuo, Cletus, Weng-Lang Yang, and Ping Wang. "The critical role of adrenomedullin and its binding protein, AMBP-1, in neuroprotection." Biological Chemistry 393, no. 6 (2012): 429–39. http://dx.doi.org/10.1515/hsz-2012-0103.

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Abstract Chronic neurodegenerative disorders and acute injuries of the central nervous system exert a prohibitive economic burden, which is aggravated by an unmet medical need for the development of effective neurotherapeutics. The evolutionarily conserved neuropeptide, adrenomedullin (AM), and its binding protein, AMBP-1, also known as complement factor H, play important roles in brain physiology, and their expression is altered in brain pathology. In this review, we discuss the molecular regulation of AM and AMBP-1 and the pivotal roles they play in neuroprotection following brain injury. We

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Nogan Bailey, Stephanie, Elizabeth C. Hardin, Rudi Kobetic, Lisa M. Boggs, Gilles Pinault, and Ronald J. Triolo. "Neurotherapeutic and neuroprosthetic effects of implanted functional electrical stimulation for ambulation after incomplete spinal cord injury." Journal of Rehabilitation Research and Development 47, no. 1 (2010): 7. http://dx.doi.org/10.1682/jrrd.2009.03.0034.

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Al-Khazaleh, Ahmad K., Xian Zhou, Deep Jyoti Bhuyan, et al. "The Neurotherapeutic Arsenal in Cannabis sativa: Insights into Anti-Neuroinflammatory and Neuroprotective Activity and Potential Entourage Effects." Molecules 29, no. 2 (2024): 410. http://dx.doi.org/10.3390/molecules29020410.

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Cannabis, renowned for its historical medicinal use, harbours various bioactive compounds—cannabinoids, terpenes, and flavonoids. While major cannabinoids like delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) have received extensive scrutiny for their pharmacological properties, emerging evidence underscores the collaborative interactions among these constituents, suggesting a collective therapeutic potential. This comprehensive review explores the intricate relationships and synergies between cannabinoids, terpenes, and flavonoids in cannabis. Cannabinoids, pivotal in cannabis’s bioac

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Castellanos, Demi M., Jiahong Sun, Joshua Yang, et al. "Acute and Chronic Dosing of a High-Affinity Rat/Mouse Chimeric Transferrin Receptor Antibody in Mice." Pharmaceutics 12, no. 9 (2020): 852. http://dx.doi.org/10.3390/pharmaceutics12090852.

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Non-invasive brain delivery of neurotherapeutics is challenging due to the blood-brain barrier. The revived interest in transferrin receptor antibodies (TfRMAbs) as brain drug-delivery vectors has revealed the effect of dosing regimen, valency, and affinity on brain uptake, TfR expression, and Fc-effector function side effects. These studies have primarily used monovalent TfRMAbs with a human constant region following acute intravenous dosing in mice. The effects of a high-affinity bivalent TfRMAb with a murine constant region, without a fusion partner, following extravascular dosing in mice a

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