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Journal articles on the topic 'Neurotrophic biomarker'

Author: Grafiati

Published: 19 February 2023

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1

Rowland, Tobias, Benjamin I. Perry, Rachel Upthegrove, et al. "Neurotrophins, cytokines, oxidative stress mediators and mood state in bipolar disorder: systematic review and meta-analyses." British Journal of Psychiatry 213, no. 3 (2018): 514–25. http://dx.doi.org/10.1192/bjp.2018.144.

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BackgroundA reliable biomarker signature for bipolar disorder sensitive to illness phase would be of considerable clinical benefit. Among circulating blood-derived markers there has been a significant amount of research into inflammatory markers, neurotrophins and oxidative stress markers.AimsTo synthesise and interpret existing evidence of inflammatory markers, neurotrophins and oxidative stress markers in bipolar disorder focusing on the mood phase of illness.MethodFollowing PRISMA (Preferred Reporting Items for Systematic reviews and Meta-analyses) guidelines, a systematic review was conduc

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2

Antunes-Lopes, Tiago, Sérgio Carvalho-Barros, Célia-Duarte Cruz, Francisco Cruz, and Carlos Martins-Silva. "Biomarkers in Overactive Bladder: A New Objective and Noninvasive Tool?" Advances in Urology 2011 (2011): 1–7. http://dx.doi.org/10.1155/2011/382431.

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Overactive bladder syndrome (OAB) is a highly prevalent urinary dysfunction, with considerable economic and human costs. Clinical diagnosis of OAB is still based on subjective symptoms. A new accurate, objective and noninvasive test to diagnose OAB and assess therapeutic outcome is lacking. Recent studies in lower urinary tract (LUT) dysfunctions, particularly in OAB patients, indicate that urinary proteins (neurotrophins, prostaglandins, and cytokines), serum C reactive protein, and detrusor wall thickness are altered, and such changes could be used as biomarkers of the disease. Nowadays, inc

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Palma-Álvarez, Raul Felipe, Elena Ros-Cucurull, Kristopher Amaro-Hosey, et al. "Peripheral levels of BDNF and opiate-use disorder: literature review and update." Reviews in the Neurosciences 28, no. 5 (2017): 499–508. http://dx.doi.org/10.1515/revneuro-2016-0078.

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AbstractSeveral neurobiological factors are related to opiate-use disorder (OUD), and among them, neurotrophins have a relevant role. Brain-derived neurotrophic factor (BDNF) is a central neurotrophin involved in many neuronal processes, and it has been related to several psychiatric diseases and addictive disorders. BDNF can be measured in plasma and serum; its levels may reflect BDNF concentrations in the central nervous system (CNS) and, indirectly, CNS processes. Hence, peripheral BDNF could be a biomarker in clinical practice. This manuscript explores the findings about peripheral BDNF an

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Almeida, Felipe Borges, Helena Maria Tannhauser Barros, and Graziano Pinna. "Neurosteroids and Neurotrophic Factors: What Is Their Promise as Biomarkers for Major Depression and PTSD?" International Journal of Molecular Sciences 22, no. 4 (2021): 1758. http://dx.doi.org/10.3390/ijms22041758.

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Even though major depressive disorder (MDD) and post-traumatic stress disorder (PTSD) are among the most prevalent and incapacitating mental illnesses in the world, their diagnosis still relies solely on the characterization of subjective symptoms (many of which are shared by multiple disorders) self-reported by patients. Thus, the need for objective measures that aid in the detection of and differentiation between psychiatric disorders becomes urgent. In this paper, we explore the potential of neurosteroids and neurotrophic proteins as biomarkers for MDD and PTSD. Circulating levels of the GA

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Mikoteit, T., S. Brand, A. Eckert, E. Holsboer-Trachsler, and J. Beck. "Brain-derived neurotrophic factor as a biomarker of insomnia." European Neuropsychopharmacology 29 (2019): S514—S515. http://dx.doi.org/10.1016/j.euroneuro.2018.11.764.

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Roda, Ângela, Inês Chendo, and Mauricio Kunz. "Biomarkers and staging of bipolar disorder: a systematic review." Trends in Psychiatry and Psychotherapy 37, no. 1 (2014): 03–11. http://dx.doi.org/10.1590/2237-6089-2014-0002.

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INTRODUCTION: A growing body of evidence suggests that bipolar disorder (BD) is a progressive disease according to clinical, biochemical and neuroimaging findings. This study reviewed the literature on the relationship between specific biomarkers and BD stages.METHODS: A comprehensive literature search of MEDLINE and PubMed was conducted to identify studies in English and Portuguese using the keywords biomarker, neurotrophic factors, inflammation, oxidative stress, neuroprogression and staging models cross-referenced with bipolar disorder.RESULTS: Morphometric studies of patients with BD found

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Perricos, Alexandra, Kazem Ashjaei, Heinrich Husslein, et al. "Increased serum levels of mBDNF in women with minimal and mild endometriosis have no predictive power for the disease." Experimental Biology and Medicine 243, no. 1 (2017): 50–56. http://dx.doi.org/10.1177/1535370217742600.

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The objective of our pilot clinical, prospective study was to determine the serum levels of mature brain-derived neurotrophic factor, in of women with endometriosis and controls and explore whether mature brain-derived neurotrophic factor is a potential biomarker for the disease. The patients were selected from the Endometriosis Marker Austria prospective cohort study conducted at the tertiary referral certified Endometriosis Center of the Medical University of Vienna. All women underwent laparoscopic surgery because there was a suspicion of endometriosis, or the women had pelvic pain, adnexal

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Eyileten, Ceren, Lucia Sharif, Zofia Wicik, et al. "The Relation of the Brain-Derived Neurotrophic Factor with MicroRNAs in Neurodegenerative Diseases and Ischemic Stroke." Molecular Neurobiology 58, no. 1 (2020): 329–47. http://dx.doi.org/10.1007/s12035-020-02101-2.

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AbstractBrain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that plays a crucial role in the development of the nervous system while supporting the survival of existing neurons and instigating neurogenesis. Altered levels of BDNF, both in the circulation and in the central nervous system (CNS), have been reported to be involved in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), multiple sclerosis (MS), and ischemic stroke. M

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Rosa, Renata F., Michelle Remião Ugolini-Lopes, Ana Paula Rossi Gandara, et al. "Cognitive dysfunction and serum levels of brain-derived neurotrophic factor (BDNF) in primary anti-phospholipid syndrome (PAPS)." Rheumatology 60, no. 1 (2020): 179–87. http://dx.doi.org/10.1093/rheumatology/keaa252.

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Abstract Objectives Cognitive dysfunction (CD) is a poorly understood non-stroke central neurological manifestation in anti-phospholipid syndrome (APS). Brain-derived neurotrophic factor (BDNF) is a neurotrophin that plays an important role in neural plasticity and could potentially be a biomarker of CD in primary APS (PAPS). The aim of the study is to assess CD in PAPS patients and to evaluate its association with clinical data, anti-phospholipid antibodies and serum BDNF levels. Methods This cross-sectional study compared 44 PAPS patients and 20 healthy controls matched for age, gender and e

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Abdullahi, Auwal, Steven Truijen, and Wim Saeys. "Neurobiology of Recovery of Motor Function after Stroke: The Central Nervous System Biomarker Effects of Constraint-Induced Movement Therapy." Neural Plasticity 2020 (June 15, 2020): 1–12. http://dx.doi.org/10.1155/2020/9484298.

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Recovery of motor function after stroke involves many biomarkers. This review attempts to identify the biomarker effects responsible for recovery of motor function following the use of Constraint-Induced Movement Therapy (CIMT) and discuss their implications for research and practice. From the studies reviewed, the biomarker effects identified include improved perfusion of motor areas and brain glucose metabolism; increased expression of proteins, namely, Brain-Derived Neurotrophic Factor (BDNF), Vascular Endothelial Growth Factor (VEGF), and Growth-Associated Protein 43 (GAP-43); and decrease

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Shen, MingJing, Zhonghua Xu, Kanqiu Jiang, Weihua Xu, Yongbin Chen, and ZhongHeng Xu. "Long noncoding nature brain-derived neurotrophic factor antisense is associated with poor prognosis and functional regulation in non–small cell lung caner." Tumor Biology 39, no. 5 (2017): 101042831769594. http://dx.doi.org/10.1177/1010428317695948.

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In this study, we evaluated the prognostic potential and functional regulation of human nature antisense, brain-derived neurotrophic factor antisense, in non–small cell lung cancer. Non–small cell lung cancer carcinoma and adjacent non-carcinoma lung tissues were extracted from 151 patients. Their endogenous brain-derived neurotrophic factor antisense expression levels were compared by quantitative reverse transcription polymerase chain reaction. Clinical relevance between endogenous brain-derived neurotrophic factor antisense expression level and patients’ clinicopathological variances or ove

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Koven, Nancy S., and Larisa R. Collins. "Urinary Brain-Derived Neurotrophic Factor as a Biomarker of Executive Functioning." Neuropsychobiology 69, no. 4 (2014): 227–34. http://dx.doi.org/10.1159/000362242.

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Buckley, Peter F. "BRAIN DERIVED NEUROTROPHIC FACTOR: ILLUSTRATIVE OF A PUTATIVE BIOMARKER FOR SCHIZOPHRENIA." Schizophrenia Research 136 (April 2012): S54. http://dx.doi.org/10.1016/s0920-9964(12)70194-9.

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Munkholm, K., M. Vinberg, and L. V. Kessing. "A peripheral composite proteomic and gene expression biomarker related to diagnosis and affective state in rapid cycling bipolar disorder." European Psychiatry 33, S1 (2016): S123. http://dx.doi.org/10.1016/j.eurpsy.2016.01.156.

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IntroductionManagement of bipolar disorder is limited by absence of laboratory test. While alterations related to multiple biological pathways have been found in bipolar disorder, findings have not translated into clinically applicable biomarkers. We previously found promise for a combined gene expression biomarker. The combination of gene expression and proteomic biomarkers could have potential as a meaningful clinical test.ObjectivesTo identify a composite biomarker based on multiple potential peripheral biomarkers related to neuroplasticity, inflammation and oxidative stress, both on a prot

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Hang, Peng-Zhou, Hua Zhu, Pei-Feng Li, et al. "The Emerging Role of BDNF/TrkB Signaling in Cardiovascular Diseases." Life 11, no. 1 (2021): 70. http://dx.doi.org/10.3390/life11010070.

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Brain-derived neurotrophic factor (BDNF) is one of the most abundant neurotrophins in the central nervous system. Numerous studies suggest that BDNF has extensive roles by binding to its specific receptor, tropomyosin-related kinase receptor B (TrkB), and thereby triggering downstream signaling pathways. Recently, growing evidence highlights that the BDNF/TrkB pathway is expressed in the cardiovascular system and closely associated with the development and outcome of cardiovascular diseases (CVD), including coronary artery disease, heart failure, cardiomyopathy, hypertension, and metabolic dis

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Wollenhaupt-Aguiar, Bianca, Diego Librenza-Garcia, Giovana Bristot, et al. "Differential biomarker signatures in unipolar and bipolar depression: A machine learning approach." Australian & New Zealand Journal of Psychiatry 54, no. 4 (2019): 393–401. http://dx.doi.org/10.1177/0004867419888027.

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Objective: This study used machine learning techniques combined with peripheral biomarker measurements to build signatures to help differentiating (1) patients with bipolar depression from patients with unipolar depression, and (2) patients with bipolar depression or unipolar depression from healthy controls. Methods: We assessed serum levels of interleukin-2, interleukin-4, interleukin-6, interleukin-10, tumor necrosis factor-α, interferon-γ, interleukin-17A, brain-derived neurotrophic factor, lipid peroxidation and oxidative protein damage in 54 outpatients with bipolar depression, 54 outpat

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Zeydi, AmirEmami, and Monir Ramezani. "Brain-derived neurotrophic factor: A promising biomarker for predicting prematurity-related complications." International Journal of Preventive Medicine 10, no. 1 (2019): 140. http://dx.doi.org/10.4103/ijpvm.ijpvm_421_18.

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Gass, Peter, and Rainer Hellweg. "Peripheral brain-derived neurotrophic factor (BDNF) as a biomarker for affective disorders?" International Journal of Neuropsychopharmacology 13, no. 01 (2009): 1. http://dx.doi.org/10.1017/s1461145709991039.

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Ghaffariyeh, Alireza, Nazafarin Honarpisheh, Mohammad Hossein Heidari, Sadollah Puyan, and Fuad Abasov. "Brain-Derived Neurotrophic Factor as a Biomarker in Primary Open-Angle Glaucoma." Optometry and Vision Science 88, no. 1 (2011): 80–85. http://dx.doi.org/10.1097/opx.0b013e3181fc329f.

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Fundaun, Joel, Melissa Kolski, Miguel Molina-Álvarez, Georgios Baskozos, and Annina B. Schmid. "Types and Concentrations of Blood-Based Biomarkers in Adults With Peripheral Neuropathies." JAMA Network Open 5, no. 12 (2022): e2248593. http://dx.doi.org/10.1001/jamanetworkopen.2022.48593.

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ImportancePeripheral neuropathies are common conditions and can result in numbness, paresthesia, motor deficits, and pain. There is increasing evidence for the use of biomarkers as clinical indicators of the presence, severity, and prognosis of nerve lesions; however, biomarker identification has largely been focused on disorders of the central nervous system, and less is known about their role in the peripheral nervous system.ObjectiveTo assess blood-based biomarker concentrations associated with nerve involvement in patients with peripheral neuropathy compared with control participants.Data

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Zwirner, Johann, Simone Bohnert, Heike Franke, et al. "Assessing Protein Biomarkers to Detect Lethal Acute Traumatic Brain Injuries in Cerebrospinal Fluid." Biomolecules 11, no. 11 (2021): 1577. http://dx.doi.org/10.3390/biom11111577.

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Diagnosing traumatic brain injury (TBI) from body fluids in cases where there are no obvious external signs of impact would be useful for emergency physicians and forensic pathologists alike. None of the previous attempts has so far succeeded in establishing a single biomarker to reliably detect TBI with regards to the sensitivity: specificity ratio in a post mortem setting. This study investigated a combination of body fluid biomarkers (obtained post mortem), which may be a step towards increasing the accuracy of biochemical TBI detection. In this study, serum and cerebrospinal fluid (CSF) sa

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Bazzari, Amjad H., and Firas H. Bazzari. "BDNF Therapeutic Mechanisms in Neuropsychiatric Disorders." International Journal of Molecular Sciences 23, no. 15 (2022): 8417. http://dx.doi.org/10.3390/ijms23158417.

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Brain-derived neurotrophic factor (BDNF) is the most abundant neurotrophin in the adult brain and functions as both a primary neurotrophic signal and a neuromodulator. It serves essential roles in neuronal development, maintenance, transmission, and plasticity, thereby influencing aging, cognition, and behavior. Accumulating evidence associates reduced central and peripheral BDNF levels with various neuropsychiatric disorders, supporting its potential utilization as a biomarker of central pathologies. Subsequently, extensive research has been conducted to evaluate restoring, or otherwise augme

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Pareek, Aditi. "Investigation of BDNF gene expression level by analysis of dysregulation of miRNA-15a: An in-silico approach." International Journal for Research in Applied Science and Engineering Technology 9, no. 8 (2021): 2293–99. http://dx.doi.org/10.22214/ijraset.2021.37693.

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Abstract: Type 2 Diabetic retinopath (T2DR) remains the leading cause of vision loss and preventable blindness in adults aged 20–74 years, particularly in middle-income and high-income countries. The pathogenesis of T2DR is a predominant cause of visual impairment and a range of hyperglycemia linked pathways have been implicated in the initiation and progression of this condition. Apparently in the past T2DR was solely considered a vascular disease as opposed to the present time where it is recognised as a neuro-vascular disease. Some pro-survival neurotrophins such as brain derived neurotroph

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Pasyk, Stanislav, Nitika Sanger, Flavio Kapczinski, and Zainab Samaan. "Evaluation of BDNF as a Biomarker for Impulsivity in a Psychiatric Population." Diagnostics 10, no. 6 (2020): 419. http://dx.doi.org/10.3390/diagnostics10060419.

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Impulsivity is an important risk factor for suicide and therefore, identifying biomarkers associated with impulsivity could be important in evaluating psychiatric patients. Currently, assessment of impulsivity is based solely on clinical evaluation. In this study, brain-derived neurotrophic factor (BDNF), a nerve growth factor, was evaluated as a potential biomarker for impulsivity. We hypothesize that elevated BDNF may result in aberrantly high neurobiological activation, promoting impulsive behaviours. A total of 343 participants were recruited for the study and were divided into two groups,

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Nurjono, Milawaty, Jimmy Lee, and Siow-Ann Chong. "A Review of Brain-derived Neurotrophic Factor as a Candidate Biomarker in Schizophrenia." Clinical Psychopharmacology and Neuroscience 10, no. 2 (2012): 61–70. http://dx.doi.org/10.9758/cpn.2012.10.2.61.

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Penadés, Rafael. "Brain-derived neurotrophic factor as a potential biomarker of cognitive recovery in schizophrenia." World Journal of Psychiatry 3, no. 4 (2013): 93. http://dx.doi.org/10.5498/wjp.v3.i4.93.

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Vinogradov, Sophia, Melissa Fisher, Christine Holland, Wendy Shelly, Owen Wolkowitz, and Synthia H. Mellon. "Is Serum Brain-Derived Neurotrophic Factor a Biomarker for Cognitive Enhancement in Schizophrenia?" Biological Psychiatry 66, no. 6 (2009): 549–53. http://dx.doi.org/10.1016/j.biopsych.2009.02.017.

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McGinty, Jacqueline F., and John E. Mendelson. "Is Brain-Derived Neurotrophic Factor a Selective Biomarker that Predicts Cocaine Relapse Outcomes?" Biological Psychiatry 70, no. 8 (2011): 700–701. http://dx.doi.org/10.1016/j.biopsych.2011.08.017.

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Borba, Ericksen, Leticia Forster, Diego Onyszko, et al. "P3-217: Brain-derived neurotrophic factor: A biomarker for diagnosis of Alzheimer's disease?" Alzheimer's & Dementia 6 (July 2010): S514. http://dx.doi.org/10.1016/j.jalz.2010.05.1716.

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Lee, Jongha, Suhyuk Chi, and Moon-Soo Lee. "Molecular Biomarkers for Pediatric Depressive Disorders: A Narrative Review." International Journal of Molecular Sciences 22, no. 18 (2021): 10051. http://dx.doi.org/10.3390/ijms221810051.

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Depressive disorder in childhood and adolescence is a highly prevalent mood disorder that tends to recur throughout life. Untreated mood disorders can adversely impact a patient’s quality of life and cause socioeconomic loss. Thus, an accurate diagnosis and appropriate treatment is crucial. However, until now, diagnoses and treatments were conducted according to clinical symptoms. Objective and biological validation is lacking. This may result in a poor outcome for patients with depressive disorder. Research has been conducted to identify the biomarkers that are related to depressive disorder.

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Bliźniewska-Kowalska, Katarzyna, Piotr Gałecki, Janusz Szemraj, and Monika Talarowska. "Expression of Selected Genes Involved in Neurogenesis in the Etiopathogenesis of Depressive Disorders." Journal of Personalized Medicine 11, no. 3 (2021): 168. http://dx.doi.org/10.3390/jpm11030168.

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(1) Background: The neurogenic theory suggests that impaired neurogenesis within the dentate gyrus of the hippocampus is one of the factors causing depression. Immunology also has an impact on neurotrophic factors. The aim of the study was to assess the importance of selected genes involved in the process of neurogenesis i.e., nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial-derived neurotrophic factor (GDNF) and neuron-restrictive silencer factor (REST gene) in the etiopathogenesis of depressive disorders. (2) Methods: A total of 189 subjects took part in the study (

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Chung, Chen Chih, Pai Hao Huang, Lung Chan, Jia-Hung Chen, Li-Nien Chien, and Chien Tai Hong. "Plasma Exosomal Brain-Derived Neurotrophic Factor Correlated with the Postural Instability and Gait Disturbance–Related Motor Symptoms in Patients with Parkinson’s Disease." Diagnostics 10, no. 9 (2020): 684. http://dx.doi.org/10.3390/diagnostics10090684.

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Brain-derived neurotrophic factor (BDNF) is an essential neurotrophin, responsible for neuronal development, function, and survival. Assessments of peripheral blood BDNF in patients with Parkinson’s disease (PD) previously yielded inconsistent results. Plasma exosomes can carry BDNF, so this study investigated the role of plasma exosomal BDNF level as a biomarker of PD. A total of 114 patients with mild to moderate PD and 42 non-PD controls were recruited, and their clinical presentations were evaluated. Plasma exosomes were isolated with exoEasy Maxi Kits, and enzyme-linked immunosorbent assa

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Zwolińska, Weronika, Maria Skibinska, Agnieszka Słopień, and Monika Dmitrzak-Węglarz. "ProBDNF as an Indicator of Improvement among Women with Depressive Episodes." Metabolites 12, no. 4 (2022): 358. http://dx.doi.org/10.3390/metabo12040358.

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Depression is a chronic psychiatric disorder with a heavy socioeconomic burden. Studies on biomarkers are needed to comprehend the pathophysiology of depression and to improve treatment outcomes. Research points to the importance of imbalance between mature brain-derived neurotrophic factor (BDNF) and its precursor, pro–brain–derived neurotrophic factor (proBDNF), in the pathophysiology of mood disorders and the potential neurodegenerative role of calcium-binding protein B (S100B). Our objective was to compare BDNF, proBDNF, and S100B serum levels before and after the treatment of acute depres

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Jiang, Yuan-Hong, Jia-Fong Jhang, Yuan-Hsiang Hsu, and Hann-Chorng Kuo. "Usefulness of Urinary Biomarkers for Assessing Bladder Condition and Histopathology in Patients with Interstitial Cystitis/Bladder Pain Syndrome." International Journal of Molecular Sciences 23, no. 19 (2022): 12044. http://dx.doi.org/10.3390/ijms231912044.

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This study investigated the usefulness of urinary biomarkers for assessing bladder condition and histopathology in patients with interstitial cystitis/bladder pain syndrome (IC/BPS). We retrospectively enrolled 315 patients (267 women and 48 men) diagnosed with IC/BPS and 30 controls. Data on clinical and urodynamic characteristics (visual analog scale (VAS) score and bladder capacity) and cystoscopic hydrodistention findings (Hunner’s lesion, glomerulation grade, and maximal bladder capacity (MBC)) were recorded. Urine samples were utilized to assay inflammatory, neurogenic, and oxidative str

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Noris-García, E., S. Arce, P. Nardin, et al. "Peripheral levels of brain-derived neurotrophic factor and S100B in neuropsychiatric systemic lupus erythematous." Lupus 27, no. 13 (2018): 2041–49. http://dx.doi.org/10.1177/0961203318804899.

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Background The aim of this study was to investigate serum S100B and brain-derived neurotrophic factor (BDNF) in systemic lupus erythematous (SLE) patients, with and without neuropsychiatric (NP) manifestation activity. Methods We assessed 47 SLE patients and 20 selected healthy individuals. Disease activity was assessed according to the SLE disease activity index (SLEDAI). Serum BDNF and S100B were measured by enzyme-linked immunosorbent assay. Results Serum S100B protein was significantly higher in SLE patients. BDNF levels were significantly decreased in active SLE, when compared with inacti

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Barengolts, Elena. "DOUBLE DIPPER: COMORBID DEPRESSION AND DIABETES, FROM A BIOMARKER TO TREATMENT. SHOULD ENDOCRINOLOGISTS BE EDUCATED TO BE AT THE FOREFRONT OF DEPRESSION TREATMENT?" Endocrine Practice 25, no. 9 (2019): 968–70. http://dx.doi.org/10.4158/ep-2019-0266.

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Abbreviations: AACE = American Association of Clinical Endocrinologists; GDNF = glial cell–derived neurotrophic factor; GFLs = GDNF family of ligands; HbA1c = glycated hemoglobin; PHQ-9 = Patient Health Questionnaire–9; SSRI = selective serotonin re-uptake inhibitor; T2D = type 2 diabetes

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Scharinger, Christian, Lucie Bartova, and Lukas Pezawas. "Brain-derived neurotrophic factor: a peripheral biomarker for major depressive disorder and antidepressant efficacy?" Personalized Medicine 8, no. 2 (2011): 115–17. http://dx.doi.org/10.2217/pme.11.9.

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Buckley, Peter, and A. Pillai. "DEFICITS IN BRAIN DERIVED NEUROTROPHIC FACTORS: POTENTIAL AS AN EARLY-PHASE BIOMARKER FOR SCHIZOPHRENIA?" Schizophrenia Research 117, no. 2-3 (2010): 125. http://dx.doi.org/10.1016/j.schres.2010.02.072.

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Wang, Long-wang, Xiao-min Han, Chao-hui Chen, Yan Ma, and Bo Hai. "Urinary brain-derived neurotrophic factor: a potential biomarker for objective diagnosis of overactive bladder." International Urology and Nephrology 46, no. 2 (2013): 341–47. http://dx.doi.org/10.1007/s11255-013-0540-x.

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Yu, Wan-Ru, Yuan-Hong Jiang, Jia-Fong Jhang, and Hann-Chorng Kuo. "Use of Urinary Cytokine and Chemokine Levels for Identifying Bladder Conditions and Predicting Treatment Outcomes in Patients with Interstitial Cystitis/Bladder Pain Syndrome." Biomedicines 10, no. 5 (2022): 1149. http://dx.doi.org/10.3390/biomedicines10051149.

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Background: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a condition causing bladder inflammation. Urinary biomarkers have been assessed as suitable for the diagnosis and treatment. This study aimed at investigating the role of urinary biomarkers in identifying bladder conditions and predicting the treatment outcome of IC/BPS. Methods: A total of 309 patients with IC/BPS and 30 controls were enrolled in this study. All patients underwent a comprehensive urological workup of symptoms, pain severity, and cystoscopic hydrodistention findings including maximal bladder capacity (MBC) and

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Zhu, Yanan, Cangang Zhang, Dongyu Zhao, et al. "BDNF Acts as a Prognostic Factor Associated with Tumor-Infiltrating Th2 Cells in Pancreatic Adenocarcinoma." Disease Markers 2021 (November 5, 2021): 1–22. http://dx.doi.org/10.1155/2021/7842035.

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Pancreatic adenocarcinoma (PAAD) is an extremely lethal disease worldwide. Brain-derived neurotrophic factor (BDNF) is a critical member of the neurotrophin polypeptide superfamily that plays an important role in multiple cancers. However, the association among BDNF expression, tumor immunity, and PAAD prognosis remains unclear. BDNF expression and its influence on patient prognosis were explored based on The Cancer Genome Atlas, Cancer Cell Line Encyclopedia, Genotype-Tissue Expression, and Kaplan-Meier plotter. Gene set enrichment analysis was performed to understand the biological roles of

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Isaka, Mitsuhiro. "Serum Concentrations of Osteoprotegerin, Brain-Derived Nerve Factor, Angiotensin II, and Endothelin-1 in aging dogs." Open Veterinary Journal 12, no. 6 (2022): 980. http://dx.doi.org/10.5455/ovj.2022.v12.i6.26.

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Background: Gerontology is a major research topic in veterinary medicine; however, there are few reports on changes in biomarker levels in aged dogs. Aim: The purpose of this preliminary study was to evaluate the differences in serum biomarker levels between young (less than 36 months) and old (over 108 months) companion dogs. Methods: We measured the serum concentrations of brain-derived neurotrophic factor (BDNF), osteoprotegerin (OPG), angiotensin II (ANGII), and endothelin-1 (ET-1) in both groups (young: n=16, 19.8±9.3 months old; old: n=16, 155.8±22.8 months old). Results: Although the co

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Ulucan, Korkut. "Brain-Derived Neurotrophic Factor and Exercise, Can It Be a New Biomarker for Athletic Performance?" Journal of Neurobehavioral Sciences 3, no. 1 (2016): 44. http://dx.doi.org/10.5455/jnbs.1456905938.

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Xu, Rongpeng, Liying Miao, Chun Yang, and Bin Zhu. "Brain‐derived neurotrophic factor: An available biomarker to predict and diagnose sarcopenia in hemodialysis patients?" Geriatrics & Gerontology International 21, no. 6 (2021): 542–43. http://dx.doi.org/10.1111/ggi.14176.

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Rocha, Ana L., Erica L. Vieira, Márcia C. Ferreira, Laura M. Maia, Antonio L. Teixeira, and Fernando M. Reis. "Plasma brain-derived neurotrophic factor in women with pelvic pain: a potential biomarker for endometriosis?" Biomarkers in Medicine 11, no. 4 (2017): 313–17. http://dx.doi.org/10.2217/bmm-2016-0327.

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Kaneko, Yoshikatsu. "Brain‐derived neurotrophic factor as a potential biomarker for sarcopenia and frailty in hemodialysis patients." Geriatrics & Gerontology International 21, no. 9 (2021): 874–75. http://dx.doi.org/10.1111/ggi.14239.

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Balietti, Marta, Cinzia Giuli, Tiziana Casoli, Paolo Fabbietti, and Fiorenzo Conti. "Is Blood Brain-Derived Neurotrophic Factor a Useful Biomarker to Monitor Mild Cognitive Impairment Patients?" Rejuvenation Research 23, no. 5 (2020): 411–19. http://dx.doi.org/10.1089/rej.2020.2307.

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Nobis, A., D. Zalewski, E. Dąbrowska, and N. Waszkiewicz. "Biochemical markers of depression - an up-to-date review." European Psychiatry 64, S1 (2021): S692. http://dx.doi.org/10.1192/j.eurpsy.2021.1833.

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Abstract:

IntroductionDepression or Major Depressive Disorder (MDD) is the most prevalent psychiatric disorder and a leading cause of disability worldwide. Currently affecting around 300 million people worldwide, depression is a major clinical, emotional, and socioeconomic strain for society. There is a growing interest in the biological underpinnings of depression, which are reflected by altered levels of biomarkers.ObjectivesThe aim of the study was to present an up-to-date review of potential MDD biomarkers.MethodsPubMed, Scopus, and Web of Science databases were searched.ResultsEnhanced inflammation

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Chakravarty, Debyani, Amber Johnson, Jeffrey Sklar, et al. "Somatic Genomic Testing in Patients With Metastatic or Advanced Cancer: ASCO Provisional Clinical Opinion." Journal of Clinical Oncology 40, no. 11 (2022): 1231–58. http://dx.doi.org/10.1200/jco.21.02767.

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PURPOSE An ASCO provisional clinical opinion offers timely clinical direction to ASCO's membership following publication or presentation of potentially practice-changing data from major studies. This provisional clinical opinion addresses the appropriate use of tumor genomic testing in patients with metastatic or advanced solid tumors. CLINICAL CONTEXT An increasing number of therapies are approved to treat cancers harboring specific genomic biomarkers. However, there is a lack of clarity as to when tumor genomic sequencing should be ordered, what type of assays should be performed, and how to

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Treble-Barna, Amery, Lacey W. Heinsberg, Ava M. Puccio, et al. "Acute Brain-Derived Neurotrophic Factor DNA Methylation Trajectories in Cerebrospinal Fluid and Associations With Outcomes Following Severe Traumatic Brain Injury in Adults." Neurorehabilitation and Neural Repair 35, no. 9 (2021): 790–800. http://dx.doi.org/10.1177/15459683211028245.

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Background. Epigenetic biomarkers have the potential to explain outcome heterogeneity following traumatic brain injury (TBI) but are largely unexplored. Objective. This exploratory pilot study characterized brain-derived neurotrophic factor ( BDNF) DNA methylation trajectories following severe TBI. Methods. Brain-derived neurotrophic factor DNA methylation trajectories in cerebrospinal fluid (CSF) over the first 5 days following severe TBI in 112 adults were examined in association with 3- and 12-month outcomes. Results. Group-based trajectory analysis revealed low and high DNA methylation gro

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