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Journal articles on the topic 'Neutrophil percentage'

Author: Grafiati

Published: 3 June 2025

Last updated: 1 August 2025

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1

Cavallaro, Elena C., Kar-Kate Liang, Kevin D. Forsyth, and Dani-Louise Dixon. "Neutrophil polarization in the airways of infants with bronchiolitis." Journal of Immunology 198, no. 1_Supplement (2017): 55.30. http://dx.doi.org/10.4049/jimmunol.198.supp.55.30.

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Abstract Pulmonary neutrophilia is observed in pediatric patients with viral-induced bronchiolitis. Despite an alleviation in clinical symptoms, our findings suggest that airway neutrophil infiltration and activation does not appear to resolve by discharge in hospitalized infants. The recent identification of neutrophil plasticity and polarization into distinct phenotypic pro-inflammatory (N1) and immunosuppressive (N2) subsets provides an unexplored avenue for regulation of the neutrophilic inflammatory response in bronchiolitis. Admission nasopharyngeal aspirate (NPA) samples were assessed f

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Dineshkumar, Thayalan, Nirmala Anandan, Rajkumar Krishnan, and Indumathi Nandhakumar. "Low-density neutrophils: A critical component in understanding the tumor microenvironment of oral squamous cell carcinoma." Journal of Oral and Maxillofacial Pathology 29, no. 2 (2025): 172–78. https://doi.org/10.4103/jomfp.jomfp_351_24.

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Abstract Background: Tumour microenvironment is one of the evading research studies in the progression of cancers. Circulating neutrophil’s contribution to tumor growth and metastatic progression has been a matter of research interest. The phenotypic subset of low-density neutrophils (LDNs) has been seen as closely associated with disease severity in various cancers. Aim and Objectives: This study aims to investigate the LDN and normal-density neutrophil (NDN) populations in oral cancer. Materials and Methods: This is prospective research in which the CD16+ population was magnetically sorted a

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Chickering, William R., John Brown, Keith W. Prasse, and Donald L. Dawe. "Effects of heterologous antineutrophil antibody in the cat." American Journal of Veterinary Research 46, no. 9 (1985): 1815–19. https://doi.org/10.2460/ajvr.1985.46.09.1815.

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SUMMARY Rabbit anti-cat neutrophil serum was injected intraperitoneally into cats to study its effects on blood neutrophil numbers, on development of neutrophils in bone marrow, and on the fate of circulating and developing neutrophils. There was a significant difference (P < 0.05) in curves of blood neutrophil numbers between antineutrophil serum (ans)- and normal rabbit serum (nrs)-injected cats; neutrophil counts tended to decrease in ans-injected cats, whereas a transient increase in counts occurred in nrs-injected cats. Significant left shifts (P < 0.05) were present in ans-injected

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Moliterno, Alison R., Donna M. Williams, Ophelia Rogers, Mary Ann Isaacs, and Jerry L. Spivak. "Disease Burden in the Chronic Myeloproliferative Disorders Correlates with the Stem Level of JAK2 V617F Expression." Blood 108, no. 11 (2006): 668. http://dx.doi.org/10.1182/blood.v108.11.668.668.

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Abstract The chronic myeloproliferative disorders (MPD), polycythemia vera (PV), essential thrombocytosis (ET) and idiopathic myelofibrosis (IMF) differ phenotypically but are linked by a common genetic lesion, JAK2V617F. Additional molecular lesions, host genetics or stem cell level of involvement are possible explanations for the differing myeloproliferative phenotypes associated with similar degrees of JAK2V617F. In this study, we examined the correlation between the stem cell level of JAK2V617F involvement and disease phenotype. The study population consisted of 35 PV, 14 ET and 7 IMF pati

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Weisenburger-Lile, David, Yuan Dong, Marion Yger, et al. "Harmful neutrophil subsets in patients with ischemic stroke." Neurology - Neuroimmunology Neuroinflammation 6, no. 4 (2019): e571. http://dx.doi.org/10.1212/nxi.0000000000000571.

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ObjectiveTo better understand the functional state of circulating neutrophils in patients with ischemic stroke (IS) for planning future clinical trials.MethodsWe analyzed by flow cytometry activation state of circulating neutrophils and the distribution of neutrophil peripheral subsets in 41 patients with acute IS less than 6 hours before admission and compared them with 22 age-matched healthy controls.ResultsOur results demonstrated continuous basal hyperactivation of circulating neutrophils during acute IS, characterized by lower l-selectin expression and higher CD11b expression at the cell

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Marjanović, V., M. Zečević, I. Budić, et al. "Percentage of Neutrophils and Neutrophil-to-Lymphocyte Ratio in Distinguishing Late from Early Prehospital Presentation of Perforated Appendicitis in Children." Nigerian Journal of Clinical Practice 27, no. 12 (2024): 1435–40. https://doi.org/10.4103/njcp.njcp_337_24.

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Introduction: White blood cell subtypes are commonly used to diagnose paediatric cases of perforated appendicitis (PA). In this study, an attempt was made to examine changes in white blood cell subtypes based on the duration of symptoms before hospitalization. Authors believe that findings will be able to describe cases of PA with delayed presentation, more accurately. Materials and Methods: A retrospective study was conducted on 139 children with diagnosis of PA admitted between 2020 and 2023. Children were divided into two groups: Group I (n = 95), with early prehospital presentation of PA (

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King, Paul T., Lovisa Dousha, Nadeene Clarke, et al. "Phagocyte extracellular traps in children with neutrophilic airway inflammation." ERJ Open Research 7, no. 2 (2021): 00883–2020. http://dx.doi.org/10.1183/23120541.00883-2020.

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Childhood lung infection is often associated with prominent neutrophilic airway inflammation and excess production of proteases such as neutrophil elastase (NE). The mechanisms responsible for this inflammation are not well understood. One potentially relevant pathway is the production of extracellular traps by neutrophils (NETs) and macrophages (METs). The aim of this study was to measure NET and MET expression in children and the effect of deoxyribonculease (DNase) 1 and α1-antitrypsin (AAT) on this process.We studied 76 children (median age of 4.0 years) with cystic fibrosis or chronic coug

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Teddleton, Hannah G., Javier J. Garza, Scott P. Greiner, and Scott A. Bowdridge. "157 Effect of Sheep Breed on Neutrophil Chemotaxis toHaemonchus Contortus Larval Antigen." Journal of Animal Science 101, Supplement_1 (2023): 105. http://dx.doi.org/10.1093/jas/skad068.126.

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Abstract Parasite-resistant St. Croix sheep generate a potent neutrophilic response to larval stages of Haemonchus contortus. Protective neutrophil responses can be best characterized by increased neutrophil infiltration to the abomasum within the first 3 days of infection. These data indicate breed differences in neutrophil chemotaxis and response to H. contortus infection. The purpose of this study was to determine differences in neutrophil chemotaxis by H. contortus third-stage larval (L3) antigen (HcLA). Suffolk (SUF) and St. Croix (STC) neutrophils were isolated and applied to matrigel-co

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Diener, A. M., P. G. Beatty, H. D. Ochs, and J. M. Harlan. "The role of neutrophil membrane glycoprotein 150 (Gp-150) in neutrophil-mediated endothelial cell injury in vitro." Journal of Immunology 135, no. 1 (1985): 537–43. http://dx.doi.org/10.4049/jimmunol.135.1.537.

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Abstract In this study we examined the importance of neutrophil adherence in neutrophil-mediated endothelial cell injury. Phorbol myristate acetate (PMA)-activated neutrophils from a patient with a congenital defect in neutrophil adherence (Gp-150 deficiency) and PMA-activated normal neutrophils pretreated with monoclonal antibody (MoAb) 60.3 were used. Both Gp-150-deficient and MoAb 60.3-treated normal neutrophils failed to adhere to cultured human umbilical vein endothelial cell (HEC) monolayers when activated by PMA (adherence less than 10% with patient and MoAb 60.3-treated cells compared

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Elistratova, I. V., Sergey G. Morozov, and I. A. Zakharova. "Expression of heat shock proteins HSP90 on neutrophils peripheral blood in patients with atopic dermatitis." Russian Journal of Skin and Venereal Diseases 19, no. 3 (2016): 151–54. http://dx.doi.org/10.18821/1560-9588-2016-19-3-151-154.

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HSP90 expression on the neutrophil plasma membrane has been investigated in patients with atopic dermatitis. Methods. Human peripheral blood cells were stained with monoclonal antibodies to the HSP90 and were analyzed using the flow cytometer. Results. Neutrophils obtained from patients with atopic dermatitis have been found to express the more significant level of HSP90 on plasma membrane, and percentage of these cells has been shown to be higherfor atopic patients compared with healthy donors. Both, neutrophil count and HSP90 fluorescence were increased according elevation of index SCORAD fo

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Terashi, Kenji, Mikio Oka, Shigehiro Ohdo, et al. "Close Association between Clearance of Recombinant Human Granulocyte Colony-Stimulating Factor (G-CSF) and G-CSF Receptor on Neutrophils in Cancer Patients." Antimicrobial Agents and Chemotherapy 43, no. 1 (1999): 21–24. http://dx.doi.org/10.1128/aac.43.1.21.

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ABSTRACT Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is used to counter chemotherapy-induced neutropenia. Our previous study showed an inverse correlation between serum rhG-CSF levels and the number of circulating neutrophils in cancer patients (H. Takatani, H. Soda, M. Fukuda, M. Watanabe, A. Kinoshita, T. Nakamura, and M. Oka, Antimicrob. Agents Chemother. 40:988–991, 1996). The aim of this study was to clarify the relationship between rhG-CSF clearance and G-CSF receptors on circulating neutrophils. In five cancer patients receiving chemotherapy, a bolus dose of rhG-CS

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Blagitz, Maiara G., Fernando N. Souza, Camila F. Batista, et al. "The neutrophil function and lymphocyte profile of milk from bovine mammary glands infected with Streptococcus dysgalactiae." Journal of Dairy Research 82, no. 4 (2015): 460–69. http://dx.doi.org/10.1017/s0022029915000308.

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Streptococcus dysgalactiaeis a bacterium that accounts for a notable proportion of both clinical and subclinical intramammary infections (IMIs). Thus, the present study explores the function of milk neutrophils and the lymphocyte profile in mammary glands naturally infected withStreptococcus dysgalactiae. Here, we used 32 culture-negative control quarters from eight clinically healthy dairy cows with low somatic cell counts and 13S. dysgalactiae-infected quarters from six dairy cows. Using flow cytometry, we evaluated the percentage of milk monocytes/macrophages and neutrophils, expression of

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Freire-Antunes, Lucas, Uyla Ornellas-Garcia, Marcos Vinicius Rangel-Ferreira, et al. "Increased Neutrophil Percentage and Neutrophil–T Cell Ratio Precedes Clinical Onset of Experimental Cerebral Malaria." International Journal of Molecular Sciences 24, no. 14 (2023): 11332. http://dx.doi.org/10.3390/ijms241411332.

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Newly emerging data suggest that several neutrophil defense mechanisms may play a role in both aggravating and protecting against malaria. These exciting findings suggest that the balance of these cells in the host body may have an impact on the pathogenesis of malaria. To fully understand the role of neutrophils in severe forms of malaria, such as cerebral malaria (CM), it is critical to gain a comprehensive understanding of their behavior and functions. This study investigated the dynamics of neutrophil and T cell responses in C57BL/6 and BALB/c mice infected with Plasmodium berghei ANKA, mu

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Xiaojie, Li, Liu Hui, Gong Zhongcheng, Wang Chenggang, and Niu Yaqi. "The Predictive Value of Interleukin-6 and Neutrophil-Lymphocyte Ratio in Patients with Severe and Extremely Severe Oral and Maxillofacial Space Infections." BioMed Research International 2021 (January 28, 2021): 1–8. http://dx.doi.org/10.1155/2021/2615059.

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Objective. To investigate the correlation between clinical manifestation and neutrophil-lymphocyte ratio, C-reactive protein (CRP), and interleukin-6 (IL-6) in the patients with severe and extremely severe oral and maxillofacial space infection (OMSI). Methods. In this retrospective study, we included 18 patients with severe and extremely severe OMSI from November 2012 to October 2018. Pearson or Spearman correlation coefficients were calculated to measure the association between the number of complications and locations and the number and percentage of lymphocyte, leukocyte, neutrophil, eosin

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ZOLOTOV, ALEXANDER N., DMITRIJ G. NOVIKOV, ELENA I. DYACHENKO, et al. "INFLUENCE OF RESPIRATORY TUBERCULOSIS CHEMOTHERAPY ON THE ABILITY OF NEUTROPHILS TO FORM EXTRACELLULAR TRAPS." Bulletin of Contemporary Clinical Medicine 17, no. 6 (2024): 37–42. https://doi.org/10.20969/vskm.2024.17(6).37-42.

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Introduction. Neutrophil extracellular traps (NETs) are essential in the pathogenesis of tuberculosis infection, but the influence of antituberculosis chemotherapy on their formation remains unexplored. Aim. The aim of the study was to analyze the effect of respiratory tuberculosis chemotherapy on the ability of neutrophils to form extracellular traps. Materials and Methods. The ability of neutrophils to form extracellular traps after being exposed to a nonspecific antigenic stimulant was studied. The study included 51 healthy children (Control Group) and 21 children with respiratory tuberculo

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Okunnu, Busola, and Rance E. Berg. "The effects of ROS on neutrophil containment of the intracellular bacteria, Listeria monocytogenes." Journal of Immunology 200, no. 1_Supplement (2018): 50.8. http://dx.doi.org/10.4049/jimmunol.200.supp.50.8.

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Abstract Extracellular superoxide dismutase (ecSOD) is commonly regarded as having a protective function during ROS induced inflammation. However, using ecSOD congenic mice expressing differing levels of ecSOD activity (HI, WT & KO), we found that high ecSOD activity is not conducive to host survival during Listeria monocytogenes (Lm) infection. Interestingly, although the infected ecSOD HI mice had a higher percentage of neutrophils present in the target organs in comparison to the ecSOD KO mice, they also had a higher bacterial burden. To better understand the function of neutrophils dur

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Djimde, Moussa, Charles Arama, Bouréma Koné, et al. "Assessment of the impact of pregnancy and malaria infection on the variation of neutrophil levels in women from San, Mali." Journal of Infection in Developing Countries 18, no. 04 (2024): 627–35. http://dx.doi.org/10.3855/jidc.18409.

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Background: In patients with severe neutropenia, infections can rapidly become serious and life-threatening. It is essential to understand whether pregnancy induces changes in neutrophil levels thereby posing an increased threat to the health of gravidae. Methodology: This cross-sectional study was conducted in San Health District (Mali) and involved pregnant women infected or not by malaria parasites and non-pregnant healthy volunteers. Subjects were categorized as having neutropenia, normal neutrophil levels, and neutrophilia regarding their neutrophil levels. A logistic regression analysis

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Bernhardt, Grisilda Vidya, Pooja Shivappa, Manjula Shantaram, Varsha Jayakar, Vinayak Lokapur, and Janita R. T. Pinto. "Phagocytic and oxidative burst activity of neutrophils in type 2 diabetic patients with foot ulcers." Biomedicine 41, no. 4 (2021): 776–80. http://dx.doi.org/10.51248/.v41i4.1122.

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Introduction and Aim: Diabetic foot ulcers are common complications seen in diabetic patients. Treatment of this disabling foot sore remains a challenge to health care professionals. This study aimed at evaluating whether the neutrophils from type 2 diabetic patients with foot ulcers present an impairment of phagocytic index and impairment in respiratory burst. We also aimed at understanding whether the impairment in neutrophil phagocytic activity can be alleviated with short course of standard treatment regime for foot ulcers. Methodology: For this case-controled study, 43 participants with t

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Panda, Bibhudatta S. K., Sunil K. Mohapatra, Mohanned N. Alhussien, and Ajay K. Dang. "Amount of Milk Neutrophil Percentage and Associated CD Molecular Changes on the Compositional and Technological Properties of Milk." Open Biotechnology Journal 13, no. 1 (2019): 129–36. http://dx.doi.org/10.2174/187407070190130129.

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Background: Changes occurring in the activity and expression of neutrophils and their transmigration through the blood mammary barrier owing to a mammary infection affecting milk quality and outcome of mastitis. Objective: To understand the role played by various neutrophil molecules on mastitis and milk quality. Methods: 18 Karan Fries cows of similar parity, milk yield and lactation stage were selected and screened for mastitis based upon milk Somatic Cell Counts (SCC) as well as California mastitis test and divided into 3 groups of 6 each i.e., healthy, sub-clinical (SCM), Clinical Mastitis

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Rehman, Haseeb U., Rizwana Salik Nukrich, Muhammad Azhar Ahmed, Syed Muhammad Umair Dilawar, and Elisha Shalim. "Evaluation of Neutrophil Percentage to Albumin Ratio as Predictor of Mortality in Patients with Covid-19." Pakistan Journal of Medical and Health Sciences 17, no. 2 (2023): 327–29. http://dx.doi.org/10.53350/pjmhs2023172327.

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Background: Inflammatory acute respiratory syndrome (SARS) is caused by the COV-2 virus. Neutrophils have been implicated in the pathophysiology of the COVID-19 pandemic since its inception, particularly in individuals with advanced disease. This is confirmed by a large number of studies. Methods: The study included 200 patients, of whom 100 were in the critical group (group 1) and 100 were in the non-critical group (group 2). White blood cell (WBC) percentage, neutrophil count, albumin, and demographic information were recorded. Neutrophil percentage x 100 /Albumin (g/dl) was used to construc

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Sweeney, Corinne R., Yves Rossier, Ellen L. Ziemer, and Susan R. Lindborg. "Effect of prior lavage on bronchoalveolar lavage fluid cell population of lavaged and unlavaged lung segments in horses." American Journal of Veterinary Research 55, no. 11 (1994): 1501–4. http://dx.doi.org/10.2460/ajvr.1994.55.11.1501.

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Summary Bronchoalveolar lavage (bal) was performed on 16 horses to determine whether it caused local or diffuse inflammation in the lungs. In 7 horses, bal was performed in both lungs twice, 48 hours apart. Although total cell counts of the bal samples did not change significantly, there were increased numbers and percentage of neutrophils in the second lavage fluid samples. In 5 horses, bal was performed in 1 lung and repeated 48 hours later in the same lung and in the corresponding airway in the contralateral lung. The absolute cell count and percentage of neutrophils were significantly (P =

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Fernandes, Cláudia A., Laurence Fievez, Bernard Ucakar, et al. "Nicotinamide enhances apoptosis of G(M)-CSF-treated neutrophils and attenuates endotoxin-induced airway inflammation in mice." American Journal of Physiology-Lung Cellular and Molecular Physiology 300, no. 3 (2011): L354—L361. http://dx.doi.org/10.1152/ajplung.00198.2010.

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Neutrophils constitute the first line of host defense against invading microorganisms. Yet their removal from the inflammatory environment is fundamental for injury restraint and resolution of inflammation. Nicotinamide, a component of vitamin B3, is known to modulate cell survival. In this study, we assessed the influence of nicotinamide on neutrophil apoptosis, both in vitro and in vivo in a mouse model of endotoxin-induced lung inflammation. In vitro, nicotinamide promoted apoptosis of human blood neutrophils in a dose-dependent manner in the presence of the apoptosis inhibitors granulocyte

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Mittal Mistry, Heer Shah, and Hemangini Vora. "Exploring the neutrophil-to-lymphocyte ratio as a prognostic biomarker in triple-negative breast cancer." International Journal of Science and Research Archive 12, no. 1 (2024): 275–85. http://dx.doi.org/10.30574/ijsra.2024.12.1.0688.

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Triple-negative breast cancer is a subtype characterized by the absence of estrogen receptor, progesterone Receptor, and Human Epidermal Growth Factor Receptor 2 receptors, limiting treatment options primarily to chemotherapy due to lack of targeted therapies typically used for other breast cancer types, hence necessitating research for improved therapeutic strategies and outcomes. The neutrophil and lymphocyte percentages, absolute counts, and the ratio of neutrophils to lymphocytes were evaluated in peripheral blood of 81 patients with triple-negative breast cancer (TNBC) and 25 healthy cont

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Santhakumar, Sreenithi, Leo Stephen, Aruna Barade, Uday Kulkarni, Biju George та Eunice S. Edison. "Dysregulation of Iron Homeostasis in β-Thalassemia and Impaired Neutrophil Activity". Thalassemia Reports 15, № 2 (2025): 4. https://doi.org/10.3390/thalassrep15020004.

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Background/Objective: Patients with beta-thalassemia are more susceptible to iron overload and have altered neutrophil function. This study investigated the connections between iron metabolism in neutrophils, neutrophil functionality, and overall iron status in individuals with β-thalassemia and sickle cell anemia. Methods: We recruited 18 patients with β-thalassemia, 5 patients with sickle cell anemia, and 15 healthy controls. Our evaluation included measurements of iron and hepcidin concentrations in the serum, along with an analysis of neutrophil function, specifically their phagocytic and

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Lieber, Jonathan G., Saiphone Webb, Benjamin T. Suratt, et al. "The in vitro production and characterization of neutrophils from embryonic stem cells." Blood 103, no. 3 (2004): 852–59. http://dx.doi.org/10.1182/blood-2003-04-1030.

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AbstractAn embryonic stem (ES) cell/OP9 coculture system for the effective production of functional neutrophils is described. A 3-step differentiation strategy was developed that uses liquid culture, enabling reliable and abundant production of neutrophils at high purity without the need of sorting for isolation of mature neutrophils. Use of the OP9 stromal cell line significantly enhances the number, percentage, and duration of differentiated neutrophils produced from embryonic stem cells. Effective and sustained differentiation of ES cells into neutrophils provides a useful model system for

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Mizgerd, Joseph P., Bruce H. Horwitz, Henry C. Quillen, Martin L. Scott, and Claire M. Doerschuk. "Effects of CD18 Deficiency on the Emigration of Murine Neutrophils During Pneumonia." Journal of Immunology 163, no. 2 (1999): 995–99. http://dx.doi.org/10.4049/jimmunol.163.2.995.

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Abstract We hypothesized that CD18 deficiency would impair the ability of neutrophils to emigrate from pulmonary blood vessels during certain pneumonias. To directly compare the abilities of wild-type (WT) and CD18-deficient neutrophils to emigrate, mice with both types of leukocytes in their blood were generated by reconstituting the hemopoietic systems of lethally irradiated C57BL/6 mice with mixtures of fetal liver cells from WT and CD18-deficient mice. Percentages of CD18-deficient neutrophils in the circulating and emigrated pools were compared during experimental pneumonias. Similar perc

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Chaves, Fernando, Bethany Tierno, and Dongsheng Xu. "Neutrophil Volume Distribution Width: A New Automated Hematologic Parameter for Acute Infection." Archives of Pathology & Laboratory Medicine 130, no. 3 (2006): 378–80. http://dx.doi.org/10.5858/2006-130-378-nvdwan.

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Abstract Context.—The number of band forms and immature neutrophils increases during acute bacterial infection. However, the determination of band counts and other neutrophil morphologic changes, such as the presence of toxic granulation, toxic vacuolization, and Dohle bodies in the cytoplasm, is labor intensive and time consuming, as it requires manual examination by an experienced medical technologist. Objective.—To investigate the value of the neutrophil volume distribution width (NDW), generated by VCS technology of the Coulter LH 750 hematology analyzer, as an additional predictor of acut

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Hanger, C. C., W. W. Wagner, S. J. Janke, T. C. Lloyd, and R. L. Capen. "Computer simulation of neutrophil transit through the pulmonary capillary bed." Journal of Applied Physiology 74, no. 4 (1993): 1647–52. http://dx.doi.org/10.1152/jappl.1993.74.4.1647.

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One-half of the neutrophils that enter the pulmonary circulation become temporarily trapped in capillaries. The neutrophils that are impeded make complete stops between free-flowing movements. These observations, based on in vivo microscopy, suggest that pulmonary margination is caused by neutrophils being impeded at focal sites in the capillary bed. To investigate the frequency with which impeding sites had to occur in the pulmonary capillaries to trap one-half of the circulating neutrophils, we developed a computer model to simulate neutrophils encountering discrete obstructions in a capilla

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Eash, Kyle J., Adam M. Greenbaum, Priya Gopalan, George A. Diaz, and Daniel C. Link. "CXCR2 Signals Act in Concert with CXCR4 to Regulate Neutrophil Release From the Bone Marrow." Blood 114, no. 22 (2009): 235. http://dx.doi.org/10.1182/blood.v114.22.235.235.

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Abstract Abstract 235 Truncation mutations of CXCR4 that cause increased receptor signaling are responsible for most cases of WHIM (warts, hypogammaglobulinemia, infections, myelokathexis) syndrome, which is characterized by the retention of mature neutrophils in the bone marrow despite peripheral neutropenia. This observation and others have established CXCR4 as a key regulator of neutrophil release from the bone marrow. However, it is unclear how modulation of neutrophil CXCR4 signaling is linked to their migration toward the vascular endothelium and subsequent entry into the circulation. Th

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Yong, K. L., and D. C. Linch. "Granulocyte-macrophage-colony-stimulating factor differentially regulates neutrophil migration across IL-1-activated and nonactivated human endothelium." Journal of Immunology 150, no. 6 (1993): 2449–56. http://dx.doi.org/10.4049/jimmunol.150.6.2449.

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Abstract The directed migration of neutrophils across vascular endothelium to localize in inflammatory tissues is controlled by soluble mediators, including cytokines and growth factors. Granulocyte-macrophage CSF (GM-CSF) enhances and primes neutrophil functions, but its specific role in the movement and localization of neutrophils to infective sites has not been clarified. We demonstrate, using an in vitro model of the vascular endothelial barrier, that GM-CSF enhances neutrophil migration across unstimulated endothelium, increasing the percentage of migrating cells from 7.7 +/- 0.9% (mean +

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Wang, Shan-Ze, Peter K. Smith, Melanie Lovejoy, Jeffrey J. Bowden, John H. Alpers, and Kevin D. Forsyth. "Shedding of L-selectin and PECAM-1 and upregulation of Mac-1 and ICAM-1 on neutrophils in RSV bronchiolitis." American Journal of Physiology-Lung Cellular and Molecular Physiology 275, no. 5 (1998): L983—L989. http://dx.doi.org/10.1152/ajplung.1998.275.5.l983.

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Bronchiolitis is characterized histologically by epithelial necrosis and peribronchial infiltration of leukocytes, with a high percentage of neutrophils in the airways. We investigated the expression of adhesion molecules (CD11a, CD11b, CD18, CD31, CD54, and CD62L) on neutrophils from nasopharyngeal aspirates (NPAs) and peripheral blood (PB) of infants with respiratory syncytial virus (RSV)-induced bronchiolitis. The expression of CD31 and CD62L on neutrophils from NPAs is decreased and the expression of CD11b, CD18, and CD54 on neutrophils from NPAs is increased compared with cells from PB of

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Lee, Ju Young, Hyun Jung Park, Yong Kyun Kim, et al. "Cellular Profiles of Bronchoalveolar Lavage Fluid and Their Prognostic Significance for Non-HIV-Infected Patients with Pneumocystis jirovecii Pneumonia." Journal of Clinical Microbiology 53, no. 4 (2015): 1310–16. http://dx.doi.org/10.1128/jcm.03494-14.

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The usefulness of bronchoalveolar lavage (BAL) fluid cellular analysis in non-human immunodeficiency virus (HIV)-infected patients withPneumocystis jiroveciipneumonia (PCP) has not been adequately evaluated. The objective of this study was to analyze the cellular profiles of BAL fluid and to evaluate their prognostic significance in non-HIV-infected patients with PCP. A 7-year retrospective cohort study of 166 non-HIV-infected adult patients with PCP who underwent BAL was performed in a tertiary care hospital. The median total BAL fluid white blood cell count was 180/μl (interquartile range, 8

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Juanita, Deifa Pricillia Tetengean, Hamzah, and Kusuma Edward. "The Effect of Stress Level, Interleukin-10 Level, Neutrophil Percentage-Albumin Ratio on Severity in COVID-19 Patients." International Journal of Innovative Science and Research Technology 7, no. 1 (2022): 508–14. https://doi.org/10.5281/zenodo.5939212.

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COVID-19 is still a global problem today. In addition to causing physical disturbances, it also causes psychological disorders and stressful conditions for patients suffering from COVID-19. This study aimed to analyze stress level, IL-10 level, albumin level, neutrophil values and NPAR on severity in COVID-19 patients. Methods: This study was an analytical observational study in a cohort prospective design. This research was conducted in June – September 2021, with patients who were confirmed to have COVID-19 in Infectious Emergency Department and Special Isolation Room of Dr. Soetomo Ge

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Okba, Ashraf, Mohamed Farres, Rasha Shahin, et al. "Neutrophil Respiratory Burst: an immunological indicator of post stroke infection." Egyptian journal of Immunology 29, no. 3 (2022): 80–89. http://dx.doi.org/10.55133/eji.290309.

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Stroke is long known to be followed by a series of immunosuppressive events, and infections might be a cause of death after an acute insult of stroke. The aim of our work was to assess the percentage of neutrophils showing spontaneous oxidative burst in patients with acute ischemic stroke. The study included 30 patients with acute cerebral infarction subjected to the following: magnetic resonance imaging of the brain immediately on admission, and blood sampling on day one of admission (baseline) and after 3 days of admission. Blood samples were used for the assessment of: differential leucocyt

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Molinari, Paula C. C., Maiara G. Blagitz, Alice M. M. P. Della Libera, Camila F. Batista, and Fernando N. Souza. "Intracellular reactive oxygen species production and phagocytosis of Staphylococcus aureus by milk neutrophils as tool to diagnose mastitis and identify susceptible dairy cows." Pesquisa Veterinária Brasileira 38, no. 4 (2018): 659–64. http://dx.doi.org/10.1590/1678-5150-pvb-4704.

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ABSTRACT: The immune response capacity of the mammary gland plays a major role to determine if mastitis will or not be established. Thus, we hypothesize that a better understanding of polymorphonuclear neutrophil leukocyte (PMN) function will elucidate mechanisms that will improve our knowledge of how we could avoid an inflammatory process by increasing the immune capacity of the cow, and even further, to search for a tool to diagnose mastitis or a possible way to select and identify non-susceptible animals. The present study utilized 112 quarters from 28 Holstein dairy cows that were divided

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Tuschong, Laura, Catherine E. Dejesus, Meredith Adams, Aylin C. Bonifacino, Dennis D. Hickstein, and Robert E. Donahue. "Leukocyte Integrin CD18 Expression Mediates Transient Neutropenia Following G-CSF Administration." Blood 114, no. 22 (2009): 3587. http://dx.doi.org/10.1182/blood.v114.22.3587.3587.

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Abstract Abstract 3587 Poster Board III-524 The mechanism whereby neutrophils traffic from the circulation in response to G-CSF has remained unclear despite the observation of ourselves and others that there is a dramatic, yet transient, loss of circulating neutrophils shortly following the administration of G-CSF in humans, non-human primates, and mice (Gordon BC, et al. Exp Hematol. 35:872-8, 2007). To determine the role of the CD18 leukocyte integrin on neutrophils in the egress of neutrophils from the circulation, we used dogs with canine leukocyte adhesion deficiency (CLAD), a genetic dis

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Sinduja, Suresh Kumar, and Rajesh Kanna Nandagopal Radha. "Analysing the association of Helicobacter pylori induced gastritis with neutrophil-lymphocyte ratio (NLR) and volume, conductance, scatter characteristics of LH780 Coulter." International Journal of Experimental Research and Review 30 (April 30, 2023): 46–56. http://dx.doi.org/10.52756/ijerr.2023.v30.005.

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Helicobacter (H.) pylori is a bacterium that infects the stomach leading to chronic gastritis. In cases of extreme infection, it can lead to condition of painful sores called peptic ulcers. To determine the association of H. pylori infection in gastric mucosa with blood parameters like Neutrophil-Lymphocyte ratio (NLR) and volume, conductance and scatter (VCS) characteristics were studied using LH780 Coulter haemogram. Blood samples of 100 normal subjects and 100-gastritis cases were collected for testing complete blood count. Biopsies of the gastric tract were also conducted for the 100 gastr

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Cakmak, Ayse, Kader Yildiz, and Neslihan Sursal. "Neutrophil isolation from feline blood using discontinuous Percoll dilutions." Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere 46, no. 06 (2018): 399–402. http://dx.doi.org/10.1055/s-0038-1677404.

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Summary Objective: Some studies have performed in vitro neutrophil isolation from feline blood. The major limiting factor for these studies is the small volume of blood that can be collected without development of potentially life-threatening complications. In the present study we attempted neutrophil isolation from feline venous blood samples using discontinuous Percoll gradients. Material and methods: Blood was collected from the cephalic vein of clinically healthy adult cats. The blood samples were layered on Percoll dilutions (72 %, 63 %, 54 % and 45 %). After centrifugation, the feline po

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Harlan, JM, PD Killen, FM Senecal, et al. "The role of neutrophil membrane glycoprotein GP-150 in neutrophil adherence to endothelium in vitro." Blood 66, no. 1 (1985): 167–78. http://dx.doi.org/10.1182/blood.v66.1.167.167.

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Abstract We have previously described two patients with a congenital defect in neutrophil function characterized by an inability to form pus. The patients' neutrophils lack a membrane glycoprotein of mol wt 150,000 daltons (GP-150) on analysis by SDS-PAGE. This glycoprotein is part of a membrane antigen complex recognized by the murine monoclonal antibody (MoAb) 60.3. Addition of MoAb 60.3 to normal neutrophils produces defects in chemotaxis and phagocytosis in vitro similar to those observed in the patients. Since neutrophil adherence to vascular endothelium is prerequisite to neutrophil emig

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Harlan, JM, PD Killen, FM Senecal, et al. "The role of neutrophil membrane glycoprotein GP-150 in neutrophil adherence to endothelium in vitro." Blood 66, no. 1 (1985): 167–78. http://dx.doi.org/10.1182/blood.v66.1.167.bloodjournal661167.

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We have previously described two patients with a congenital defect in neutrophil function characterized by an inability to form pus. The patients' neutrophils lack a membrane glycoprotein of mol wt 150,000 daltons (GP-150) on analysis by SDS-PAGE. This glycoprotein is part of a membrane antigen complex recognized by the murine monoclonal antibody (MoAb) 60.3. Addition of MoAb 60.3 to normal neutrophils produces defects in chemotaxis and phagocytosis in vitro similar to those observed in the patients. Since neutrophil adherence to vascular endothelium is prerequisite to neutrophil emigration in

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Grishina, Zoryana V., Galina M. Viryasova, Yulia M. Romanova, and Galina F. Sud’ina. "Polymorphonuclear Leukocyte Apoptosis Is Accelerated by Sulfatides or Sulfatides-TreatedSalmonellaTyphimurium Bacteria." BioMed Research International 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/381232.

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Neutrophils die by apoptosis following activation and uptake of microbes or enter apoptosis spontaneously at the end of their lifespan if they do not encounter a pathogen. Here we report that sulfatides or sulfatides-treatedSalmonellaTyphimurium bacteria accelerated human neutrophil apoptosis. Neutrophil apoptosis was examined by flow cytometry. Sulfatides caused prominent increase in percentage of apoptotic cells after 2.5 hrs of incubation.SalmonellaTyphimurium bacteria by themselves did not affect the basal level of apoptosis in neutrophil population. When neutrophils were added toS.Typhimu

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Dhanesha, Nirav, Manasa K. Nayak, Prakash Doddapattar та ін. "Targeting myeloid-cell specific integrin α9β1 inhibits arterial thrombosis in mice". Blood 135, № 11 (2020): 857–61. http://dx.doi.org/10.1182/blood.2019002846.

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Abstract Evidence suggests that neutrophils contribute to thrombosis via several mechanisms, including neutrophil extracellular traps (NETs) formation. Integrin α9β1 is highly expressed on neutrophils when compared with monocytes. It undergoes affinity upregulation on neutrophil activation, and stabilizes adhesion to the activated endothelium. The role of integrin α9 in arterial thrombosis remains unexplored. We generated novel myeloid cell-specific integrin α9−/− mice (α9fl/flLysMCre+) to study the role of integrin α9 in arterial thrombosis. α9fl/fl littermates were used as controls. We repor

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Gregory, Alyssa D., Lisa A. Hogue, Thomas W. Ferkol, and Daniel C. Link. "Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection." Blood 109, no. 8 (2006): 3235–43. http://dx.doi.org/10.1182/blood-2005-01-015081.

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AbstractGranulocyte colony-stimulating factor (G-CSF) regulates the production, maturation, and function of neutrophils. Its expression is often induced during infection, resulting in high concentrations of G-CSF in inflammatory exudates and in the blood, suggesting that it may regulate both local and systemic neutrophil responses. Herein, we characterize the neutrophil response in G-CSFR−/− mice following intratracheal injection with Pseudomonas aeruginosa–laden agarose beads, modeling the pulmonary infection observed in many patients with cystic fibrosis. G-CSFR−/− mice are markedly suscepti

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Gregory, Alyssa D., Lisa A. Hogue, Thomas W. Ferkol, and Daniel C. Link. "Regulation of Systemic and Local Neutrophil Responses by G-CSF during Pulmonary Pseudomonas aeruginosa Infection." Blood 104, no. 11 (2004): 1460. http://dx.doi.org/10.1182/blood.v104.11.1460.1460.

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Abstract Granulocyte colony-stimulating factor (G-CSF) expression is often induced during infection, resulting in high concentrations of G-CSF in inflammatory exudates and in the blood. This increased expression suggests that G-CSF may regulate both local and systemic neutrophil responses. Previous studies of G-CSF or G-CSF receptor deficient (G-CSFR−/−) mice challenged with different infectious agents have provided conflicting results concerning the importance of G-CSF in the regulation of stress granulopoiesis. In the present study, we use a physiologically-relevant infectious model in which

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Bikbavova, G. R., M. A. Livzan, D. G. Novikov, A. N. Zolotov, and N. A. Kirichenko. "Neutrophil extracellular traps in patients with ulcerative colitis." Meditsinskiy sovet = Medical Council, no. 8 (June 18, 2025): 152–61. https://doi.org/10.21518/ms2025-227.

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Introduction. The pathogenesis of ulcerative colitis (UC) is based on damage to the intestinal mucosa, increased expression of proinflammatory cytokines, and activation of inflammatory cells, including neutrophils. The degree of neutrophil infiltration of the intestinal mucosa determines the severity of clinical manifestations, endoscopic findings, and systemic manifestations of inflammation.Aim. The study was to compare the parameters of the systemic inflammatory response with changes in the ability of neutrophils to form extracellular traps in patients with ulcerative colitis (UC).Materials

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Hendy, RashaM, MonaA Elawady, and AmiraI Mansour. "Assessment of neutrophil/lymphocyte percentage in bronchial asthma." Egyptian Journal of Chest Diseases and Tuberculosis 68, no. 1 (2019): 74. http://dx.doi.org/10.4103/ejcdt.ejcdt_112_18.

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Ibrahim, Safaa A., Arpita Kulshrestha, Gajendra K. Katara, and Kenneth D. Beaman. "Delayed neutrophil apoptosis is regulated by cancer associated a2 isoform vacuolar ATPase." Journal of Immunology 198, no. 1_Supplement (2017): 76.15. http://dx.doi.org/10.4049/jimmunol.198.supp.76.15.

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Abstract Neutrophils are short life span cells but they can live for weeks in cancer tissues and promote tumor progression. Identifying cancer derived factors that enhance neutrophil survival will provide new targets for cancer therapy. A peptide from the N-terminal domain of a2- isoform vacuolar ATPase (a2NTD) is specifically secreted from cancer cells and promotes the neutrophil protumorigenic properties which in turn, enhance tumor progression. This gives a2NTD the propensity to regulate neutrophil survival. In fact the treatment of human neutrophils with recombinant a2NTD led to 2.1 fold i

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Matsumoto, Takeshi, Toshihiro Kaneko, Hideo Wada, et al. "Increased Membrane Proteinase 3 Expression on Neutrophils in Patients with Infectious Disease." Blood 104, no. 11 (2004): 3806. http://dx.doi.org/10.1182/blood.v104.11.3806.3806.

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Abstract Proteinase-3 (PR3) is an abundant serine proteinase stored in azurophilic granules of neutrophils and released to the cell surface upon activation. PR3 expression near a vascular surface likely contributes to local tissue destruction and inflammation. PR3 is generally known as the primary target antigen of PR3-anti-neutrophil cytoplasmic antibodies (ANCA) in Wegener’s granulomatosis (WG), an autoimmune vasculitis. There are many reports about neutrophil PR3 expression in WG, but few reports about PR3 in patients with common inflammatory disorders. Using FCM, we examined membrane PR3 (

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Foster, Jennifer E., Katherine Gott, Mark R. Schuyler, Wieslaw Kozak, and Yohannes Tesfaigzi. "LPS-induced neutrophilic inflammation and Bcl-2 expression in metaplastic mucous cells." American Journal of Physiology-Lung Cellular and Molecular Physiology 285, no. 2 (2003): L405—L414. http://dx.doi.org/10.1152/ajplung.00249.2002.

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Our previous studies show that Bcl-2, a regulator of apoptosis, may be involved in the reduction of mucous cell metaplasia (MCM) during recovery from inflammatory responses. The present study was to determine whether neutrophilic inflammation mediates Bcl-2 expression in mucous cells. Rats were intratracheally instilled with 50–1,000 μg of LPS. The number of neutrophils recovered by bronchoalveolar lavage (BAL) increased with the dose of LPS, and the percentage of Bcl-2-expressing cells increased with the numbers of neutrophils in the BAL. Depletion of neutrophils did not reduce MCM, but the p

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Adi, Darmadi. "STUDI NEUTROFIL PADA PENDERITA DEMAM TIFOID DI RSUD PETALA BUMI PEKANBARU." Jurnal Sains dan Teknologi Laboratorium Medik 6, no. 1 (2021): 11–15. http://dx.doi.org/10.52071/jstlm.v6i1.72.

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Typhoid fever is an acute fever caused by the salmonella bacteria which attacks the digestive tract and other organs of the body. The purpose of this study was to determine the percentage of neutrophil stab and neutrophil segments in patients with typhoid fever with titers 1/320 and to determine the morphology of neutrophil segments in patients with typhoid fever with titers 1/320. The design of this research is descriptive research, a descriptive cross-sectional study. The place and time of the study were carried out at Pekanbaru Petala Bumi General Hospital in December 2018 - June 2019. The

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