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Dissertations / Theses on the topic 'Nevirapine'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Injety, Sahana. "Formulation of a nevirapine co-crystal as a liquid dosage form." University of the Western Cape, 2016. http://hdl.handle.net/11394/5060.

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Magister Pharmaceuticae - MPharm<br>Co-crystals are a solid phase phenomena that could enhance the physicochemical properties of an active pharmaceutical ingredient. A co-crystal has never been incorporated into a liquid dosage form with the assurance of maintaining its co-crystal state until absorption under defined conditions. This study aims to develop a liquid formulation with a nevirapine co-crystal. A protocol was developed to investigate all the five co-formers that were used to make the nevirapine co-crystals to-date. The most appropriate co-former was selected for a liquid dosage form

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2

Silva, Cecilia Carolina Pinheiro da. "Caracterização de estado sólido de insumos farmacêuticos ativos: clorpropamida, nevirapina e dietilcarbamazina." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-29042010-092012/.

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A indústria farmacêutica tem como principal objetivo planejar, sintetizar e caracterizar compostos químicos que possuam atividade biológica e que sejam úteis no controle e combate de doenças e sintomas que acometem as populações. Estes compostos são referidos como ingredientes farmacêuticos ativos e podem, no estado sólido, apresentar diferentes arranjos de suas moléculas dentro de um cristal (polimorfismo). A cada um desses arranjos estão associadas propriedades físico-químicas que são de fundamental importância para o efeito terapêutico dos fármacos. Nesse contexto, este estudo teve como obj

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3

Bolognesi, Natasha. "The media management of Nevirapine: content, causes and consequences." Thesis, Stellenbosch : University of Stellenbosch, 2006. http://hdl.handle.net/10019.1/2616.

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Thesis (MPhil (Journalism))--University of Stellenbosch, 2006.<br>This study presents an observation, analysis and effect indication of the media portrayal of the antiretroviral drug nevirapine in Western Cape daily newspapers. The research is aimed at ascertaining the quality and consequences of science reporting on an essential, yet too often politically controversial, AIDS treatment within the South African context. This work ultimately offers suggestions as to how the media could play a more beneficial role for the South African public when reporting on nevirapine and HIV/AIDS treatment in

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4

Cornejo, Castro Elena Maria. "Characterisation of molecular mechanisms involved in nevirapine-induced hypersensitivity." Thesis, University of Liverpool, 2014. http://livrepository.liverpool.ac.uk/19073/.

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The non-nucleoside reverse transcriptase inhibitor nevirapine (NVP) is widely used in the treatment of human immunodeficiency virus infection in many sub- Saharan countries. However, NVP-treated individuals have a 5% risk of developing hypersensitivity reactions (HSRs), ranging from maculopapular exanthema to life-threatening severe cutaneous eruptions and hepatotoxicity. A number of clinical (gender and CD4+ T cell count) as well as immunogenetic factors (MHC class I and class II alleles) have been associated with NVP hypersensitivity, but the predictive value is poor. Gene expression analyse

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5

Geldenhuys, Brandon Lindsay. "Dissolution and antiviral activity of a novel nevirapine formulation." Thesis, University of the Western Cape, 2014. http://hdl.handle.net/11394/4653.

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Magister Pharmaceuticae - MPharm<br>The author’s objective was to follow the product life-cycle process of a novel antiretroviral, nevirapine formulation in South Africa, to generate and compile data to pursue market registration. Five supramolecular co-crystals, viz. nevirapine-saccharin (NVSC), nevirapine-DL-tartaric acid (NVTTA), nevirapine-maleic acid (NVMLE), nevirapine-glutaric acid (NVGLT) and nevirapine-salicylic acid (NVSLI) were reproduced and confirmed by powder X-ray diffraction (PXRD). A pre-formulation study ensued to identify the most appropriate co-former candidate to formulate

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6

Mwila, Chiluba. "The development and assessment of sustained release nevirapine tablets." Thesis, Rhodes University, 2013. http://hdl.handle.net/10962/54667.

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The use of antiretroviral (ARV) agents in the management of HIV/AIDS has significantly improved the lifestyle and wellbeing of patients. Despite the success that has been achieved with the use of ARV therapy, the occurrence of adverse effects and unpredictable bioavailability associated with most of these drugs remains a major concern. Nevirapine (NVP) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that is used in combination with other ARV compounds for the treatment of HIV-1 infections. It is also used for the prevention of mother to child transmission of the HIV-1 virus. NVP is

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7

Thaw, Htwe Min Punnee Pitisuttithum. "Evaluate the efficacy of nevirapine based regimen and boosted Pi based regimen followed by nevirapine based regimen in treatment naive advanced HIV patients /." Abstract, 2006. http://mulinet3.li.mahidol.ac.th/thesis/2549/cd388/4838795.pdf.

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Thematic paper (M.C.T.M. (Clinical Tropical Medicine))--Mahidol University, 2006.<br>LICL has E-Thesis 0012 ; please contact computer services. LIRV has E-Thesis 0012 ; please contact circulation services.

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8

Zheve, Georgina Teurai. "Neuroprotective mechanisms of nevirapine and efavirenz in a model of neurodegeneration." Thesis, Rhodes University, 2008. http://hdl.handle.net/10962/d1003285.

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AIDS Dementia Complex (ADC) is a neurodegenerative disorder implicated in HIV-1 infection that is associated with elevated levels of the neurotoxin, quinolinic acid (QA) which causes a cascade of events to occur, leading to the production of reactive oxygen species (ROS), these being ultimately responsible for oxidative neurotoxicity. In clinical studies, Non-nucleoside reverse transcriptase inhibitors (NNRTIs), efavirenz (EFV) and nevirapine (NVP) have been shown to potentially delay the progressive degeneration of neurons, thus reducing the frequency and neurological deficits associated with

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9

Britz, Carel Marthinus. "Nevirapine in pro-Pheroid : a preservative efficacy and stability study / Carlie Britz." Thesis, North-West University, 2009. http://hdl.handle.net/10394/4752.

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Human immunodeficiency virus (HIV) is a retrovirus that can lead to acquired immunodeficiency syndrome (AIDS), a condition in humans in which the immune system begins to fall, leading to life-threatening opportunistic infections.• As of January 2006, the Joint United Nations Programme on HIV/AIDS (UNAIDS) and the World Health Organization (WHO) estimate that AIDS has killed more than 25 million people since it was first identified on December 1, 1981, making it one of the most destructive pandemics in recorded history. Pheroid technology is a patented delivery system that consists of both pla

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10

MARINHO, Aline Teixeira. "New insights on nevirapine use: a mechanistic perspective of its toxic events." Master's thesis, Instituto de Higiene e Medicina Tropical, 2013. http://hdl.handle.net/10362/16880.

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Introdução: A nevirapina (NVP) é um fármaco amplamente utilizado para o tratamento da infecção pelo vírus da imunodeficiência humana de tipo 1 (VIH-1), no entanto, a sua utilização na terapêutica crónica tem sido associada à toxicidade hepática e cutânea. O sexo feminino é um factor de risco para o desenvolvimento destes eventos tóxicos, mas as razões para essa diferença entre o sexo feminino e masculino não estão completamente esclarecidas. Diferenças na biotransformação da NVP e na formação de metabolitos tóxicos podem ser as causas subjacentes. O presente trabalho teve como objectivo explor

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11

Tenneti, Vijay Seshadri. "The characteristics of HIV patients who are long-term responders to nevirapine." Thesis, Curtin University, 2007. http://hdl.handle.net/20.500.11937/986.

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Objective: To define Nevirapine long term responders (NLTRs) and identify the characteristics of patients who stay on the drug for long periods of time without adverse effects and maintain suppression of HIV replication without development of resistance.Methodology: Demographic and clinical data was collected for all the patients >18 years old from Department of Clinical Immunology, Royal Perth Hospital, Western Australia. All the patients included in the study received Nevirapine as part of their first regimen of anti-retroviral therapy. Data collection and analysis were divided in three grou

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12

Lee, Chun-Yuan, Hui-Min Chang, Calvin M. Kunin, Susan Shin-Jung Lee, Yao-Shen Chen, and Hung-Chin Tsai. "Efficacy and safety of switching from nevirapine immediate-release twice daily to nevirapine extended-release once daily in virologically suppressed HIV-infected patients: a retrospective cohort study in Taiwan." BIOMED CENTRAL LTD, 2017. http://hdl.handle.net/10150/623929.

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Background: Whether the non-inferior efficacy and safety results of switching virologically suppressed HIV-1-infected patients from nevirapine immediate-release (NVP-IR) to NVP extended-release (NVP-XR) demonstrated in the TRANxITION study conducted in Europe and North America are also applicable to virologically suppressed HIV-infected Taiwanese patients remains unknown. We evaluated the comparative safety and efficacy of continuing NVP-IR versus switching to NVP-XR in virologically suppressed HIV-infected Taiwanese adults receiving combined antiretroviral therapy (cART) regimens. Methods: We

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13

Dias, Clara Lúcia Gonçalves. "HDL in HIV-1 infection: a quality perspective through paraoxonase-1 activities." Master's thesis, Faculdade de Ciências e Tecnologia, 2013. http://hdl.handle.net/10362/10840.

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Dissertação para obtenção do Grau de Mestre em Genética Molecular e Biomedicina<br>Cardiovascular disease is highly prevalent on human immunodeficiency virus (HIV)-infected young adults, with serious implications on the choice of the most cardiovascular friendly antiretroviral regimen and its management. Nevirapine (NVP) is an antiretroviral drug that, although associated with hepatotoxicity and skin rash, is currently recognized as a high-density lipoprotein (HDL) booster in HIV-infected patients. This HDL booster effect is even more pronounced than the current available drugs for this purpo

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14

Witika, Bwalya Angel. "The development, manufacture and characterisation of niosomes intended to deliver nevirapine to the brain." Thesis, Rhodes University, 2017. http://hdl.handle.net/10962/65257.

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15

Ketwaroo, Bibi Farahnaz K. "Detection of positive selection resulting from Nevirapine treatment in longitudinal HIV-1 reverse transcriptase sequences." Thesis, University of the Western Cape, 2006. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_7052_1182227727.

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<p>Nevirapine (NVP) is a cheap anti-retroviral drug used in poor countries worldwide, administered to pregnant women at the onset of labour to inhibit HIV enzyme reverse transcriptase. Viruses which may get transmitted to newborns are deficient in this enzyme, and HIV-1 infection cannot be established, thereby preventing mother to child transmission (MTCT). In some cases, babies get infected and positive selection for viruses resistant to nevirapine may be inferred. Positive selection can be inferred from sequence data, when the rate of nonsynonymous substitutions is significantly greater than

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16

Moholisa, Retsilisitsoe R. "Pharmacokinetic-Pharmacogenetic-and-Pharmacodynamic Adherence Relationships in Cohort South African HIV Infected Children on Lopinavir-and Nevirapine-Based Regimens." Doctoral thesis, Faculty of Health Sciences, 2019. http://hdl.handle.net/11427/30123.

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Background: Antiretroviral therapy (ART), notably lopinavir and nevirapine substantially reduces Human immune-deficiency virus (HIV) associated morbidity and mortality in HIVinfected children. Low concentrations of nevirapine and lopinavir have been linked to inferior virological outcomes; it is recommended that lopinavir and nevirapine concentrations are maintained above 1 mg/L and 3 mg/L, respectively, in order to maintain viral suppression. Adherence to both lopinavir and nevirapine ART, respectively has long known to be a crucial contributor to HIV treatment success. Lopinavir and nev

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17

Lai, Weidong George. "Bioactivation of trimethoprim, fluperlapine and nevirapine, roles of iminoquinone-type Michael acceptors in idiosyncratic drug reactions." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ49973.pdf.

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18

Srivastava, Abhishek. "Metabolism and bioactivation of nevirapine in humans and rats : Integrated application of NMR and mass spectrometry." Thesis, University of Liverpool, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526804.

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19

Kim, Yong Ho. "Population pharmacokinetics and pharmacodynamics of zidovudine, didanosine and nevirapine in children and adolescents with advanced HIV disease." Scholarly Commons, 2000. https://scholarlycommons.pacific.edu/uop_etds/2722.

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The population pharmacokinetics and pharmacodynamics (PK/PD) of nevirapine (NVP), zidovudine (ZDV), and didanosine (ddI) were evaluated in 432 pediatric patients with HIV, randomized to receive either a double-therapy of ZDV + ddI or NVP + ddI; or triple-therapy of NVP + ZDV + ddI as a substudy of the AIDS Clinical Trials Group Protocol 245 in 2 phases. In phase 1, nonlinear mixed-effect modeling (NONMEM) analysis was employed for population pharmacokinetics (PPK) study for ZDV, ddI and NVP. One-compartment model with first-order input and first-order elimination was fitted to the NVP, ZDV and

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20

Eloraby, Ghada. "Identification of protein targets of nevirapine reactive metabolites using click chemistry and mass spectrometry-based differential proteomics." Mémoire, Université de Sherbrooke, 2016. http://hdl.handle.net/11143/8995.

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Abstract : Adverse drug reactions (ADRs) are undesirable effects caused after administration of a single dose or prolonged administration of drug or result from the combination of two or more drugs. Idiosyncratic drug reaction (IDR) is an adverse reaction that does not occur in most patients treated with a drug and does not involve the therapeutic effect of the drug. IDRs are unpredictable and often life-threatening. Idiosyncratic reaction is dependent on drug chemical characteristics or individual immunological response. IDRs are a major problem for drug development because they are usually n

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21

Oluoch, Okumu Fredrick. "Synthesis and characterization of bimetallic silver and platinum nanoparticles as electrochemical sensor for nevirapine, an anti-HIV drug." Thesis, Cape Peninsula University of Technology, 2016. http://hdl.handle.net/20.500.11838/2319.

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Thesis (DTech (Chemistry))--Cape Peninsula University of Technology, 2016.<br>Bimetallic silver-platinum (Ag-Pt) nanoparticles (NPs) were synthesized via simultaneous reduction of varying mole fractions of metal precursors H2PtCl6.6H2O and AgNO3 by sodium citrate. Kinetics rates of were as follows; Ag NPs (0.079 s-1), Ag-Pt NPs 1:1 (0.082 s-1) and Pt NPs (0.006 s-1). The UV visible spectrum of Ag NPs exhibited a characteristic absorption band while Pt NPs and Ag-Pt bimetallic NPs exhibited no absorption peaks. Successful formation of both monometallic and bimetallic NPs was confirmed via trans

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22

Cohen, Karen. "Effect of rifampicin-based antitubercular therapy on nevirapine plasma concentrations in South African adults with HIV-associated tuberculosis." Master's thesis, University of Cape Town, 2013. http://hdl.handle.net/11427/3277.

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Includes bibliographical references.<br>Sub-Saharan Africa is overwhelmed by dual epidemics of human immunodeficiency virus (HIV) and tuberculosis (TB) infection. Non-nucleoside reverse-transcriptase inhibitor (NNRTI)-based antiretroviral therapy (ART) is recommended for first-line treatment in adult HIV treatment programmes in resource-limited settings [1]. Many South African HIV-infected patients initiate ART while on TB treatment, 38 percent in one local study [2]. In addition, although ART reduces the incidence of TB, incidence in patients on ART is higher than in the HIV uninfected popula

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23

Saw, Eindani Aung Wirach Maek-A.-Nantawat. "Incidence and predictors of toxicity among aids patients treated with nevirapine based regimen at Bamrasnaradura Institute, Nonthaburi, Thailand /." Abstract, 2006. http://mulinet3.li.mahidol.ac.th/thesis/2549/cd388/4838794.pdf.

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Thematic Paper (M.C.T.M. (Clinical Tropical Medicine))--Mahidol University, 2006.<br>LICL has E-Thesis 0012 ; please contact computer services. LIRV has E-Thesis 0012 ; please contact circulation services.

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24

Rodrigues, Patrícia Marques. "Nevirapine in an animal model of pre-diabetes: study of drug pharmacokinetic and its effects on fasting glycemia and insulin resistance." Master's thesis, Faculdade de Ciências e Tecnologia, 2014. http://hdl.handle.net/10362/11103.

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Dissertação para obtenção do Grau de Mestre em Biotecnologia<br>The increased incidence of type II diabetes has emerged as a major concern in controlled human immunodeficiency virus (HIV)infection. There is a general lack of data to support the best combined antiretroviral therapy (cART) option to treat HIV-patients with pre-diabetes and nevirapine has been described has a glucose-friendly antiretroviral. On the other hand, it is known that diabetes could influence the pharmacokinetics of several drugs. This aspect is particularly relevant for drugs with narrow therapeutic window, which is th

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De, Villiers Janene Oosthuizen. "Combination antiretroviral therapy : formulation of a powder for oral suspension containing Lamivudine, Zidovudine and Nevirapine / Janene Oosthuizen de Villiers." Thesis, North-West University, 2006. http://hdl.handle.net/10394/15.

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26

Manyama, Tebogo Lennox. "Powder characteristics and tabletting of nevirapine prepared by a novel process : a solubility and stability study / Tebogo Lennox Manyama." Thesis, North-West University, 2011. http://hdl.handle.net/10394/8387.

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The science of powders in the pharmaceutical industry is a specialised field and the particle size of a powder may influence its bulk performance, its tabletting properties and handling. During the synthesis process of an API, the crystal form is dependent on the solvent being used in the final stage of recrystallisation. Usually, the particle size is too large for use as is, in which case milling would be the next step in the production line-up. Milling of APIs can result in polymorphic phase transformations, contamination, and costly product losses through dust. The understanding of the phys

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Mutenda, Nicholus Mbangu. "Adverse effects experienced by patients on first line antiretroviral drugs used at Keetmanshoop Hospital (Namibia)." University of the Western Cape, 2015. http://hdl.handle.net/11394/4549.

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>Magister Scientiae - MSc<br>Adverse effects are a significant factor that determine how long patients will tolerate a given antiretroviral drug regimen. They also influence treatment options, and play an important role in the much needed adherence to treatment by patients on Highly Active Antiretroviral Therapy (HAART). This study is aimed at understanding adverse effects experienced by patients on the first line antiretroviral therapy at Keetmanshoop Hospital in Namibia. Methods : A retrospective quantitative method was used to review records of patients on first line antiretroviral treat

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28

Ngcongwane, Phindile G. "Missed Opportunities of Preventing Mother to Child Transmission Programme at Germiston District Hospital in 2004." Diss., University of Pretoria, 2006. http://hdl.handle.net/2263/61725.

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Background: The vertical transmission of HIV from mother to child ranges from 15 to 40%. The preventing mothers to child transmission programme (PMTCT) services have been introduced during the past five years in South Africa; however vertical transmission of HIV remains high. Objectives: The objectives of the study were: 1. To describe the clinical and demographic characteristics of women attending the ANC clinic and delivering at the Germiston Hospital; 2. To determine the proportion of women who were offered voluntary counselling and testing (VCT) in 2004; 3. To determine the propor

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Megazzini, Karen M. "Provision of rapid HIV testing and nevirapine administration in Zambian labor wards to improve population antiretroviral coverage of HIV-infected women and their HIV-exposed infants." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2009r/megazzini.pdf.

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Akanlu, George Bruno. "Willingness to pay for VCT and nevirapine for the prevention of mother to child transmission of HIV in the Kassena-Nankana district of Northern Ghana." Master's thesis, University of Cape Town, 2004. http://hdl.handle.net/11427/8631.

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Includes bibliographical references.<br>Mother-to-child-transmission (MTGT) of HIV is one of the tragic consequences of the HIV pandemic, There are antiretrovirals for the prevention of mother-to-child-transmission (PMTCT) and Nevirapine (NVP) is the cheapest, most feasible and highly cost-effective of all and suitable for resource poor settings. Voluntary Counselling and HIV Testing (VCT), known for its effectiveness in behavioral change, is also essential for the prevention of mother-to-child transmission of HIV and for the control of HIV/AIDS. Family Health International and Ghanaian MOH in

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Dang, Van Phuc Polrat Wilairatana. "Efficacy and adverse events of three antiretroviral drug combination (stavudine, lamivudine and nevirapine) in the treatment of adult HIV/AIDS patients at Chonburi regional hospital /." Abstract, 2003. http://mulinet3.li.mahidol.ac.th/thesis/2546/4538027.pdf.

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Arrivé, Élise. "La nevirapine en dose unique pour prévenir la transmission mère-enfant du VIH-1 dans les pays à ressources limitées : résistance virale et stratégies alternatives." Bordeaux 2, 2007. http://www.theses.fr/2007BOR21476.

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La nevirapine (NVP), administrée en dose unique à la mère et à l'enfant, est une stratégie simple, efficace et abordable pour prévenir la transmission mère-enfant du VIH-1 (PTME). Elle induit cependant une résistance virale pouvant avoir un impact négatif sur la réponse aux traitements antirétroviraux (ARV) ultérieurs de première ligne recommandés dans les pays à ressources limitées. Une revue systématique de la littérature et une méta-analyse de données résumées ont été réalisées pour estimer la prévalence de la résistance virale chez les femmes et les enfants quatre à huit semaines après exp

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Elsherbiny, Doaa. "Pharmacokinetic drug-drug interactions in the management of malaria, HIV and tuberculosis." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8426.

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Mohammednur, Mohammedmekin Mohammedseid. "Adverse pregnancy outcomes among HIV-positive pregnant women treated with efavirenz-containing antiretroviral drugs: a retrospective cohort study in the Cape Flats." Thesis, University of the Western Cape, 2017. http://hdl.handle.net/11394/6185.

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Doctor Pharmaceuticae - Dpharm<br>The use of efavirenz (EFV) in the first trimester of pregnancy remains controversial. In South Africa, the use of EFV-containing antiretroviral therapy (ART) as part of a Fixed Dose Combination (FDC) during the first trimester of pregnancy started in April, 2013. Literature to date has reported conflicting outcomes following the use of EFV-containing ART during the first trimester of pregnancy. The objectives of the study were to determine the prevalence of adverse pregnancy outcomes among HIV-positive pregnant women treated with EFV-containing ART and compare

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Harmon, Amanda L. "Preventing Mother-to-Child Transmission of Human Immunodeficiency Virus-1 (HIV-1): Effects of Intrapartum and Neonatal Single-Dose Nevirapine Prophylaxis and Subsequent HIV-1 Drug Resistance at Antiretroviral Treatment Initiation." Scholarship @ Claremont, 2011. http://scholarship.claremont.edu/cmc_theses/305.

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The prevention of mother-to-child transmission is one of the most powerful tools in human immunodeficiency virus type 1 (HIV-1) prevention and has huge potential to improve both maternal and child health. In the absence of any preventative measures, infants born to and breastfed by their HIV-positive mothers have roughly a one-in-three chance of acquiring the infection themselves. HIV can be passed on from mother-to-child during pregnancy, during labor and delivery, and even after during breastfeeding. Intrapartum and neonatal single-dose nevirapine (sd-NVP) is the foundation of preventing mot

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Ngandu, Nobubelo Kwanele. "Factors associated with Nevirapine adherence in the prevention of mother-to-child transmission of HIV in the Free State province of South Africa and discrepancies between service records and cord-blood surveillance." Master's thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/13244.

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Includes bibliographical references.<br>Sub-Saharan Africa holds 90% of the HIV-infected children worldwide and most of them are infected through vertical transmission. The elimination of mother-to-child transmission of HIV in this region can be achieved through complementing prophylaxis regimens with effective service delivery. The latter should involve reaching all those at risk and optimizing adherence through adequate and routine follow-up. A study set out to assess the effectiveness of preventing mother-to-child transmission (PMTCT) programs in four African countries including South Afric

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Mtombeni, Sifelani. "Community perceptions, attitudes and knowledge regarding mother to child transmission of HIV: a baseline evaluation before the implementation of the Prevention of Mother to Child Transmission of HIV Program using a short course of Nevirapine at Onandjokwe Hospital, Namibia." Thesis, University of the Western Cape, 2004. http://etd.uwc.ac.za/index.php?module=etd&amp.

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Each year approximately 600 000 infants, most of them in Sub-Saharan Africa are born with HIV infection as a result of mother to child transmission of HIV. Whereas significant progress has been made in reduction of mother to child transmission of HIV in developed countries, the situation remains desperate in developing countries. Progress has been hampered by shortage of staff, facilities, limited access to voluntary counselling and testing and lack of support for women by their partners and communities. The challenge is to increase voluntary counselling and testing uptake during antenatal car

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Sousa, Mendes Maïlys de. "Prédiction du passage transplacentaire in-vivo des médicaments à partir de modèles ex-vivo." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCB144/document.

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Les femmes enceintes sont exposées à de nombreux médicaments et les essais cliniques sont difficilement réalisables dans cette population, c'est pourquoi avoir une méthode qui permet d'estimer l'ampleur des modifications de pharmacocinétique chez la femme enceinte et le passage transplacentaire est essentiel. En effet les modifications physiologiques prennent place durant cette période clé. Nous avons développé des modèles pharmacocinétiques basé sur la physiologie (PBPK) et intégré les modifications physiologiques connues survenant durant la grossesse. Ils décrivent bien la pharmacocinétique

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Römsing, Susanne. "Development and Validation of Bioanalytical Methods : Application to Melatonin and Selected Anti-Infective Drugs." Doctoral thesis, Uppsala universitet, Analytisk kemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-131519.

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This thesis describes bioanalytical methods for measuring melatonin and some anti-infective drugs in biological fluids. Solid-phase extraction (SPE) or protein precipitation was used for enrichment and purification of the analytes and Liquid Chromatography (LC) was used to analyze the samples. Developed methods were validated according to international guidelines. Melatonin is a hormone secreted by the pineal gland with a robust circadian rhythm. Bioanalytical methods for determination of melatonin in plasma and saliva have been developed which were used for monitoring melatonin levels in volu

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Alves, Mónica Filipa Neves Moço. "Sistemas bacterianos no estudo da bioactivação do antirectroviral nevirapina." Master's thesis, Faculdade de Ciências e Tecnologia, 2013. http://hdl.handle.net/10362/8671.

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Dissertação apresentada na Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa para obtenção do Grau de Mestre em Genética Molecular e Biomedicina<br>O antirectroviral Nevirapina (NVP) é um inibidor não nucleosídico da transcriptase reversa (INNTR) aplicado contra infecções pelo vírus da imunodeficiência humana tipo 1 (HIV-1), cuja utilização é principalmente limitada pela hepatotoxicidade severa e erupções cutâneas associadas. Embora o mecanismo exacto da toxicidade de NVP não seja completamente conhecido, estudos prévios sugeriram que a bioactivação de NVP possa ocorrer por hid

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Maria, Maciel Lavra Zenia. "Obtenção tecnológica de antiretroviral dose-fixa combinada à base de zidovudina, lamivudina e nevirapina." Universidade Federal de Pernambuco, 2006. https://repositorio.ufpe.br/handle/123456789/3652.

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Made available in DSpace on 2014-06-12T16:32:46Z (GMT). No. of bitstreams: 2 arquivo6463_1.pdf: 1938424 bytes, checksum: 52ba0c7bd79a83d6fca575ddac24eeab (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2006<br>O acesso ao tratamento antiretroviral aos pacientes infectados nos países em desenvolvimento é uma prioridade da saúde pública mundial. Novos fármacos e associações terapêuticas têm proporcionado uma maior adesão ao tratamento, diminuindo a mortalidade pelo vírus HIV e melhorando a qualidade de vida dos pacientes infectados. Tendo em

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Malm, Mikaela. "Drug Analysis : Bioanalytical Method Development and Validation." Doctoral thesis, Uppsala universitet, Analytisk kemi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8547.

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This thesis describes bioanalytical methods for drug determination in biological matrixes, with drugs in focus used against diseases largely affecting low-income countries. Solid-phase extraction is used for sample cleanup, and processed samples are analyzed by liquid chromatography. Developed bioanalytical methods are validated according to international guidelines. Eflornithine (DFMO) is a chiral drug, used for treating human African trypanosomiasis. A bioanalytical method for determination of DFMO enantiomers in plasma is presented. The enantiomers are detected by evaporative light-scatteri

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Siedler, Sana. "Estratégias de cristalização e caracterização de cocristais e cristais modificados da nevirapina." reponame:Repositório Institucional da UFSC, 2015. https://repositorio.ufsc.br/xmlui/handle/123456789/169586.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2015.<br>Made available in DSpace on 2016-10-19T13:12:55Z (GMT). No. of bitstreams: 1 336844.pdf: 3161632 bytes, checksum: aab4ccd37e8e15413531d8ca9d8ded26 (MD5) Previous issue date: 2015<br>A nevirapina (NVP) é um fármaco antirretroviral pertencente à classe dos inibidores não nucleosídeos da transcriptase reversa, usado para o tratamento da infecção pelo vírus HIV. Pertence à classe II do Sistema de Classificação Biofarmacêutica (SCB), ou seja,

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Kasenga, Fyson. "Making it happen prevention of mother to child transmission of HIV in rural Malawi /." Doctoral thesis, Umeå : Umeå university, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-26223.

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Renata, Queiroz de Farias Silvia. "Desenvolvimento de comprimidos revestidosdose-fixa-combinada estavudina + lamivudina + nevirapina para tratamento da AIDS." Universidade Federal de Pernambuco, 2006. https://repositorio.ufpe.br/handle/123456789/3648.

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Made available in DSpace on 2014-06-12T16:32:44Z (GMT). No. of bitstreams: 2 arquivo6461_1.pdf: 1514992 bytes, checksum: 371b23e18f6865a5dc4d02abbedf5f97 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2006<br>É prioridade de saúde pública mundial a introdução de novos agentes anti-retrovirais no mercado, e no Brasil, o Ministério da Saúde (MS), de acordo com a lei n° 9.313/96, tem garantido distribuição gratuita de medicamentos a todos os portadores do HIV e doentes de AIDS , assegurando tratamento anti-retroviral adequado para cada está

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Sousa, Marcelo de 1980. "Preparação de nanopartículas lipídicas sólidas NLS para liberação modificada/prolongada de fármacos antiretrovirais (Nevirapina, Saquinavir e Efavirenz)." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/250356.

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Orientador: Francisco Benedito Teixeira Pessine<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Química<br>Made available in DSpace on 2018-08-23T23:52:35Z (GMT). No. of bitstreams: 1 Sousa_Marcelode_D.pdf: 3494030 bytes, checksum: 462ff3b363ece6e2ff2f83e5d1028485 (MD5) Previous issue date: 2013<br>Resumo: Nos dias atuais não há cura e nem vacina para as pessoas portadoras de HIV. A erradicação do vírus não é possível porque a maioria está depositado em órgãos que são de difícil acesso aos fármacos antirretrovirais. Uma alternativa seria direcionar os fármacos à estes ó

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Kunz, Andrea Ursula [Verfasser]. "Prävention der HIV Mutter-Kind Übertragung mittels Nevirapin und antiretrovirale Therapie in Subsahara-Afrika / Andrea Ursula Kunz." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2008. http://d-nb.info/1022825089/34.

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Mauelshagen, Anna [Verfasser]. "Praktikabilität und Verträglichkeit einer antiretroviralen Therapie mit Nevirapin oder Efavirenz bei Patienten mit HIV/HCV-Koinfektion / Anna Mauelshagen." Kiel : Universitätsbibliothek Kiel, 2018. http://d-nb.info/1162496495/34.

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Clemens, Simon Daniel [Verfasser], and Hartwig [Gutachter] Klinker. "Nevirapin- und Efavirenz-Serumkonzentrationen im Rahmen der antiretroviralen Therapie bei HIV-infizierten schwangeren Frauen in Südafrika / Simon Daniel Clemens ; Gutachter: Hartwig Klinker." Würzburg : Universität Würzburg, 2017. http://d-nb.info/1132995825/34.

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Kutun, Kim Karen [Verfasser], Gabriele [Gutachter] Arendt, and Eva [Gutachter] Neuen-Jacob. "Provoziert eine Langzeittherapie mit Efavirenz bei HIV-positiven Patienten neurokognitive Defizite? - Ein Vergleich mit Nevirapin / Kim Karen Kutun ; Gutachter: Gabriele Arendt, Eva Neuen-Jacob." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2021. http://d-nb.info/1232490083/34.

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