Log in

Relevant bibliographies by topics / New Coumarins / Journal articles

To see the other types of publications on this topic, follow the link: New Coumarins.

Journal articles on the topic 'New Coumarins'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'New Coumarins.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

SAVITRI, D. SRIVASTAVA, K. SRIVASTAVA SANTOSH, and SHRIVASTAVA SANDHYA. "New Coumarins from Murraya paniculata." Journal of Indian Chemical Society Vol. 73, Dec 1996 (1996): 666–68. https://doi.org/10.5281/zenodo.5928242.

Full text

Abstract:

Department of Chemistry, Dr. H. S. Gour University, Sagar-470 003 <em>Manuscript received 15 December 1994, revised 18 April 1995, accepted 15 June 1995</em> An extract of the stem bark of Mrraya paniculata has yielded three new coumarins 8-(butenyl-3'-methyl)-7-<em>O</em>-β-D-galactopyranoside, 7 -methoxy-8-(2' -isovaleryloxy-3-butenyl-3-methyl)coumarin and marmesin-4'-<em>ο</em>-α-L-arabinopyranoside alongwith 3,5,6,7 ,8,3' ,4' ,5' -octamethoxyflavone, 7-methoxy-8-(3-butenyl-3-methyl-2-oxo)coumarin and 7-methoxy-8-(butenyl-3'-methyl)coumarin.

APA, Harvard, Vancouver, ISO, and other styles

2

Chattopadhyay, Kalicharan, Erik Fenster, Alexander J. Grenning, and Jon A. Tunge. "Palladium-catalyzed substitution of (coumarinyl)methyl acetates with C-, N-, and S-nucleophiles." Beilstein Journal of Organic Chemistry 8 (July 27, 2012): 1200–1207. http://dx.doi.org/10.3762/bjoc.8.133.

Full text

Abstract:

The palladium-catalyzed nucleophilic substitution of (coumarinyl)methyl acetates is described. The reaction proceeds though a palladium π-benzyl-like complex and allows for many different types of C-, N-, and S-nucleophiles to be regioselectively added to the biologically active coumarin motif. This new method was utilized to prepare a 128-membered library of aminated coumarins for biological screening.

APA, Harvard, Vancouver, ISO, and other styles

3

Bhila, Varun G., Yogita L. Chovatiya, Chirag V. Patel, Rakesh R. Giri, and Dinkar I. Brahmbhatt. "A Convergent Approach for the Synthesis of New Pyrazolyl Bipyridinyl Substituted Coumarin Derivatives as Antimicrobials." International Letters of Chemistry, Physics and Astronomy 40 (October 2014): 1–16. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.40.1.

Full text

Abstract:

Some new 3-[3-(1-phenyl-3-aryl-1H-pyrazol-4-yl) acryloyl] coumarins 3a-f were synthesized (coumarin chalcones) by the condensation of various 3-acetyl coumarins 1 and appropriate 1-phenyl-3-aryl-1H-pyrazole-4-carbaldehyde 2. These coumarin chalcones 3a-f were then employed for the synthesis of pyrazolyl bipyridinyl substituted coumarins 7a-f, 8a-f, and 9a-f under Krohnke’s reaction condition. The characterization of all the synthesized compounds was carried out by elemental analysis, IR, 1H-NMR, 13C-NMR, DEPT-135 and mass spectral analysis. In addition to that, in vitro antimicrobial competenc

APA, Harvard, Vancouver, ISO, and other styles

4

Bhila, Varun G., Yogita L. Chovatiya, Chirag V. Patel, Rakesh R. Giri, and Dinkar I. Brahmbhatt. "A Convergent Approach for the Synthesis of New Pyrazolyl Bipyridinyl Substituted Coumarin Derivatives as Antimicrobials." International Letters of Chemistry, Physics and Astronomy 40 (October 23, 2014): 1–16. http://dx.doi.org/10.56431/p-y6404d.

Full text

Abstract:

Some new 3-[3-(1-phenyl-3-aryl-1H-pyrazol-4-yl) acryloyl] coumarins 3a-f were synthesized (coumarin chalcones) by the condensation of various 3-acetyl coumarins 1 and appropriate 1-phenyl-3-aryl-1H-pyrazole-4-carbaldehyde 2. These coumarin chalcones 3a-f were then employed for the synthesis of pyrazolyl bipyridinyl substituted coumarins 7a-f, 8a-f, and 9a-f under Krohnke’s reaction condition. The characterization of all the synthesized compounds was carried out by elemental analysis, IR, 1H-NMR, 13C-NMR, DEPT-135 and mass spectral analysis. In addition to that, in vitro antimicrobial competenc

APA, Harvard, Vancouver, ISO, and other styles

5

Nascimento, Jainara Santos do, Wilson Elias Rozo Núñez, Valmore Henrique Pereira dos Santos, Josefina Aleu, Sílvio Cunha, and Eliane de Oliveira Silva. "Mapping the Biotransformation of Coumarins through Filamentous Fungi." Molecules 24, no. 19 (2019): 3531. http://dx.doi.org/10.3390/molecules24193531.

Full text

Abstract:

Natural coumarins are present in remarkable amounts as secondary metabolites in edible and medicinal plants, where they display interesting bioactivities. Considering the wide enzymatic arsenal of filamentous fungi, studies on the biotransformation of coumarins using these microorganisms have great importance in green chemical derivatization. Several reports on the biotransformation of coumarins using fungi have highlighted the achievement of chemical analogs with high selectivity by using mild and ecofriendly conditions. Prompted by the enormous pharmacological, alimentary, and chemical inter

APA, Harvard, Vancouver, ISO, and other styles

6

Sravani G, Linga Naik A, Kranthi A, and Priyanka G. "Preparation and Analysis of Coumarin Compound for New Application." International Research Journal of Pharmaceutical and Applied Sciences 8, no. 4 (2020): 33–35. http://dx.doi.org/10.26452/irjpas.v8i4.1321.

Full text

Abstract:

Numerous normally occurring substances usually applied in famous drugs the world over, incorporate the coumarin moiety. Coumarin speaks to a unique platform for restorative scientists, in light of its unconventional physicochemical highlights, and the adaptable and easy engineered change right into a huge assortment of functionalized coumarone. As an outcome, countless coumarin subordinates were dependent, incorporated, and tried to cope with numerous pharmacological focuses in a particular way, e.G., specific chemical inhibitors, and all of the extra as of past due, numerous chose targets (mu

APA, Harvard, Vancouver, ISO, and other styles

7

Bevans, Carville, Andreas Fregin, Christof Geisen, Clemens Müller-Reible, Matthias Watzka, and Johannes Oldenburg. "Current pharmacogenetic developments in oral anticoagulation therapy: The influence of variant VKORC1 and CYP2C9 alleles." Thrombosis and Haemostasis 98, no. 09 (2007): 570–78. http://dx.doi.org/10.1160/th07-07-0454.

Full text

Abstract:

SummaryFor decades coumarins have been the most commonly prescribed drugs for therapy and prophylaxis of thromboembolic conditions. Despite the limitation of their narrow therapeutic dosage window, the broad variation of intra- and inter-individual drug requirement, and the relatively high incidence of bleeding complications,prescriptions for coumarins are increasing due to the aging populations in industrialised countries.The identification of the molecular target of coumarins,VKORC1, has greatly improved the understanding of coumarin treatment and illuminated new perspectives for a safer and

APA, Harvard, Vancouver, ISO, and other styles

8

Mohammed, Ali Y., and Luma S. Ahamed. "Synthesis of New Substituted Coumarin Derivatives containing Schiff-Base as Potential Antimicrobial and Antioxidant Agents." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 03 (2022): 1279–81. http://dx.doi.org/10.25258/ijddt.12.3.58.

Full text

Abstract:

By unusual method for separating two isomers of a substituted nitro-coumarin using a soxhlet extractor and in controlling temperature to get a selective nitration reaction, several new Schiff base coumarins were synthesized from nitro coumarins as starting material, which were reduced by Fe in glacial acetic acid to produce corresponding amino coumarin derivatives. Then the latter was reacted with different aromatic aldehydes to produce the desired Schiff bases derivatives. After characterization by Fourier transform infrared (FT-IR), Proton nuclear magnetic resonance (1HNMR) and Carbon-13 nuc

APA, Harvard, Vancouver, ISO, and other styles

9

Abdallah, Mira, Akram Hijazi, Frédéric Dumur, and Jacques Lalevée. "Coumarins as Powerful Photosensitizers for the Cationic Polymerization of Epoxy-Silicones under Near-UV and Visible Light and Applications for 3D Printing Technology." Molecules 25, no. 9 (2020): 2063. http://dx.doi.org/10.3390/molecules25092063.

Full text

Abstract:

In this study, eight coumarins (coumarins 1–8) are proposed as near-UV and blue light sensitive photoinitiators/photosensitizers for the cationic polymerization (CP) of epoxysilicones when combined with 4-isopropyl-4’-methyldiphenyliodonium tetrakis(pentafluorophenyl)borate (IOD). Among these coumarins, four of them (coumarins 1, 2, 6 and 8) have never been reported in the literature, i.e., these structures have been specifically designed to act as photoinitiators for silicones upon near UV and visible irradiation. Good final reactive epoxy function conversions (FCs) and also high rates of pol

APA, Harvard, Vancouver, ISO, and other styles

10

BASHIR, Moath Kahtan, Yasser Fakri MUSTAFA, and Mahmood Khudhayer OGLAH. "SYNTHESIS AND ANTITUMOR ACTIVITY OF NEW MULTIFUNCTIONAL COUMARINS." Periódico Tchê Química 17, no. 36 (2020): 871–83. http://dx.doi.org/10.52571/ptq.v17.n36.2020.886_periodico36_pgs_871_883.pdf.

Full text

Abstract:

Cancer constitutes one of the most severe public health menaces worldwide. It is imperative to synthesize new compounds and explore their antitumor activity to find a potential resolution to this health problem. Synthesis of new scaffolds and evaluating their antitumor activity is a relevant approach for combating cancer development. Coumarins can exhibit diverse biological activities, and one of these is the antitumor activity. This study aimed to synthesize new coumarins by grafting their precursors to the aromatic amines via Schiff base formation and evaluating their introductory antitumor

APA, Harvard, Vancouver, ISO, and other styles

11

Rastija, Vesna. "Computer-Aided Design of Novel Active Components in Plant Protection." MOLECULAR SCIENCES AND APPLICATIONS 4 (May 9, 2024): 1–6. http://dx.doi.org/10.37394/232023.2024.4.1.

Full text

Abstract:

The production demands highly specific environmentally and toxicologically acceptable plant protection products are increasing. Computer-aided molecular design of new active components has a great deal in developing plant protection products to avoid that long-lasting and expensive process. Computational design of future compounds and their synthesis, evaluation of their effectiveness on harmful and beneficial organisms in the soil, as well as detailed research mechanism of action at the molecular level, represents an initial stage in the long-lasting and expensive process of plant protection

APA, Harvard, Vancouver, ISO, and other styles

12

Pandya, Mahesh K., Tapan H. Parekh, Mehulsinh R. Chhasatia, and Nileshkumar D. Vala. "Synthesis and characterization of some novel coumarin based various 2-aryl-pyrido [3,2-c] coumarins." Journal of Drug Delivery and Therapeutics 10, no. 2 (2020): 158–63. http://dx.doi.org/10.22270/jddt.v10i2.3933.

Full text

Abstract:

A survey of the literature reveals that the number of coumarin derivatives having heterocyclic moieties either as substituent groups or fused with parent coumarin nucleus possesses a variety of functions and are widely used in drugs and dyes. Because of this wide utility, the synthesis of coumarin has remained a subject of active interest. Looking at the importance of these heterocoumarins and with a view to exploring new methods of their synthesis, the present work was undertaken and this synthesis deals with various 2-aryl-pyrido [3,2-c] coumarins. The compounds have been synthesized by reac

APA, Harvard, Vancouver, ISO, and other styles

13

Xia-Hou, Zhen-Ru, Xiao-Fei Feng, Yu-Fei Mei, et al. "5-Demethoxy-10′-ethoxyexotimarin F, a New Coumarin with MAO-B Inhibitory Potential from Murraya exotica L." Molecules 27, no. 15 (2022): 4950. http://dx.doi.org/10.3390/molecules27154950.

Full text

Abstract:

Rutaceae plants are known for being a rich source of coumarins. Preliminary molecular docking showed that there was no significant difference for coumarins in Clausena and Murraya, both of which had high scoring values and showed good potential inhibitory activity to the MAO-B enzyme. Overall, 32 coumarins were isolated from Murraya exotica L., including a new coumarin 5-demethoxy-10′-ethoxyexotimarin F (1). Their structures were elucidated on the basis of a comprehensive analysis of 1D and 2D NMR and HRMS spectroscopic data, and the absolute configurations were assigned via a comparison of th

APA, Harvard, Vancouver, ISO, and other styles

14

Liu, Siqi, Aolin Ma, Jie Li, Zhixuan Du, Longfei Zhu, and Guanping Feng. "Coumarin Promotes Hypocotyl Elongation by Increasing the Synthesis of Brassinosteroids in Plants." International Journal of Molecular Sciences 26, no. 3 (2025): 1092. https://doi.org/10.3390/ijms26031092.

Full text

Abstract:

Coumarins are natural products commonly found in plants and are typical allelopathic substances that strongly affect the growth of plants after being exudated from the root and help plants absorb Fe in cases of iron deficiency. Although coumarins have been found to have multiple effects, this understanding is still relatively limited. Here, we show that coumarin significantly promotes the elongation of the hypocotyl by enhancing cell elongation. Further research has found that coumarin increases the content of BR in plants by enhancing the expression of brassinosteroid (BR) synthesis genes. Th

APA, Harvard, Vancouver, ISO, and other styles

15

Ukirde, R. D., R. B. Patil, and S. D. Sawant. "Design, Synthesis and Evaluation of Antioxidant Activity of Some Coumarin Derivatives." Asian Journal of Organic & Medicinal Chemistry 4, no. 3 (2019): 138–43. http://dx.doi.org/10.14233/ajomc.2019.ajomc-p172.

Full text

Abstract:

Coumarin derivatives are an important class of heterocyclic compounds, specifically 4-amino substituted coumarins with antioxidant, anticancer activities. The above observations prompted us to synthesize new coumarins with various substitutions. The starting material 4-chloro-2H-chromen-2-one was synthesized by refluxing a mixture of 4-hydroxy-2H-chromen-2-one in phosphoryl chloride. The 4-substituted amine derivatives of coumarin were synthesized by refluxing 4-chloro-2H-chromen-2- one with 4-substituted amines and anhydrous K2CO3 and methanol. All the eleven 4-substituted amine derivatives o

APA, Harvard, Vancouver, ISO, and other styles

16

Pereira, Thiago Moreira, Daiana Portella Franco, Felipe Vitorio, and Arthur Eugen Kummerle. "Coumarin Compounds in Medicinal Chemistry: Some Important Examples from the Last Years." Current Topics in Medicinal Chemistry 18, no. 2 (2018): 124–48. http://dx.doi.org/10.2174/1568026618666180329115523.

Full text

Abstract:

Coumarins are natural products characterized as 1,2 benzopyrones widely distributed in plants, as well as, in many species of fungi and bacteria. Nowadays, many synthetic procedures allow the discovery of coumarins with expanded chemical space. The ability to exert noncovalent interactions with many enzymes and receptors in live organisms lead the coumarins to exhibit a wide range of biological activities and applications. Then, this manuscript provides an overview of the use of coumarins compounds in medicinal chemistry in treating many diseases. Important examples of the last years have been

APA, Harvard, Vancouver, ISO, and other styles

17

Pasricha, Sharda, and Pragya Gahlot. "Synthetic Strategies and Biological Potential of Coumarin-Chalcone Hybrids: A New Dimension to Drug Design." Current Organic Chemistry 24, no. 4 (2020): 402–38. http://dx.doi.org/10.2174/1385272824666200219091830.

Full text

Abstract:

Privileged scaffolds are ubiquitous as effective templates in drug discovery regime. Natural and synthetically derived hybrid molecules are one such attractive scaffold for therapeutic agent development due to their dual or multiple modes of action, minimum or no side effects, favourable pharmacokinetics and other advantages. Coumarins and chalcone are two important classes of natural products affording diverse pharmacological activities which make them ideal templates for building coumarin-chalcone hybrids as effective biological scaffold for drug discovery research. Provoked by the promising

APA, Harvard, Vancouver, ISO, and other styles

18

Latté, Klaus Peter, Oliver Kayser, N. Tan, Macki Kaloga, and Herbert Kolodziej. "Unusual Coumarin Patterns of Pelargonium Species Forming the Origin of the Traditional Herbal Medicine Umckaloabo." Zeitschrift für Naturforschung C 55, no. 7-8 (2000): 528–33. http://dx.doi.org/10.1515/znc-2000-7-809.

Full text

Abstract:

Abstract The coumarin patterns of Pelargonium sidoides DC. and Pelargonium reniforme CURT., forming the origin of the herbal medicine “umckaloabo”, were analysed and compared for therapeutic equivalence. For both species, members of tri- and tetraoxygenated coumarins almost exclusively were present in the respective metabolic pools. However, the roots of P. sidoides and P. reniforme expressed conspicuously distinct coumarin variations, with umckalin, its 7-O-methyl ether, 7-acetoxy-5,6-dimethoxycoumarin, 6,8-dihydroxy-7-methoxycoumarin, 6,8-dihydroxy-5,7-tetramethoxycoumarin, artelin and three

APA, Harvard, Vancouver, ISO, and other styles

19

Elmusa, Safa, Muna Elmusa, Benan Elmusa, and Rahmi Kasımoğulları. "Coumarins: Chemical Synthesis, Properties and Applications." Düzce Üniversitesi Bilim ve Teknoloji Dergisi 13, no. 1 (2025): 131–70. https://doi.org/10.29130/dubited.1441144.

Full text

Abstract:

Coumarins are compounds characterized by a benzopyrone structure resulting from the condensation of pyrone and a benzene ring. They are commonly found as secondary metabolites in various plants, microorganisms, and sponges. These metabolites play a crucial role in defence mechanisms, and extensive research has revealed numerous biological activities associated with these compounds. Coumarin and its derivatives show significant potential as candidates for new drugs due to their exceptional biocompatibility and a wide range of biological activities, including antimicrobial, anticancer, antimitot

APA, Harvard, Vancouver, ISO, and other styles

20

Anufrik, Slavamir S., Vikentiy V. Tarkovsky, and Sergey N. Anuchin. "Spectral and generation properties of new coumarins – benzopyrylium derivatives." Journal of the Belarusian State University. Physics, no. 2 (June 6, 2022): 19–25. http://dx.doi.org/10.33581/2520-2243-2022-2-19-25.

Full text

Abstract:

The spectral and generation parameters of coumarins, benzopyrylium derivatives, in ethanol and acetonitrile under coherent excitation were studied. It was found that the absorption spectra of the investigated compounds contain several maxima and the structuredness of the spectra is associated with their bichromophoric structure. It is shown that these organic dyes are bichromophoric compounds. It is noted that the nature of the substituents in positions 6 and 7 of the coumarin base and positions 6′ and 7′ of the benzopyrylium core determines their spectral-luminescent and lasing properties. It

APA, Harvard, Vancouver, ISO, and other styles

21

Singh, Atamjit, Karanvir Singh, Kamaljit Kaur, et al. "Coumarin as an Elite Scaffold in Anti-Breast Cancer Drug Development: Design Strategies, Mechanistic Insights, and Structure–Activity Relationships." Biomedicines 12, no. 6 (2024): 1192. http://dx.doi.org/10.3390/biomedicines12061192.

Full text

Abstract:

Breast cancer is the most common cancer among women. Currently, it poses a significant threat to the healthcare system due to the emerging resistance and toxicity of available drug candidates in clinical practice, thus generating an urgent need for the development of new potent and safer anti-breast cancer drug candidates. Coumarin (chromone-2-one) is an elite ring system widely distributed among natural products and possesses a broad range of pharmacological properties. The unique distribution and pharmacological efficacy of coumarins attract natural product hunters, resulting in the identifi

APA, Harvard, Vancouver, ISO, and other styles

22

Venidiktova O. V., Gorelik A. M., Koshkin A. V., and Barachevsky V. A. "Spectral-kinetic study of new hybrid photochromic cumarinopyrans with reversible fluorescence modulation." Optics and Spectroscopy 130, no. 5 (2022): 483. http://dx.doi.org/10.21883/eos.2022.05.54430.5-22.

Full text

Abstract:

Photochromic hybrid compounds based on coumarins with reversible fluorescence modulation have been synthesized for the first time. It was shown that UV irradiation leads to spectral and fluorescent changes due to the structure of the compounds. Keywords: photochromism, naphthopyran, coumarin, spectroscopy, fluorescence, hybrids.

APA, Harvard, Vancouver, ISO, and other styles

23

Tosun, Fatma, John Beutler, Tanya Ransom, and Mahmut Miski. "Anatolicin, a Highly Potent and Selective Cytotoxic Sesquiterpene Coumarin from the Root Extract of Heptaptera anatolica." Molecules 24, no. 6 (2019): 1153. http://dx.doi.org/10.3390/molecules24061153.

Full text

Abstract:

Seven known sesquiterpene coumarins and a new sesquiterpene coumarin, anatolicin (8), were isolated from the dichloromethane extract of the roots of Heptaptera anatolica. Structures of these compounds were elucidated based on their spectral properties. While some of these sesquiterpene coumarins showed modest cytotoxic activity against COLO205, KM12, A498, UO31, and TC32 cancer cell lines, selective cytotoxicity of anatolicin (8) and 14′-acetoxybadrakemin (7) were observed at nanomolar level against the UO31 kidney cancer cell line.

APA, Harvard, Vancouver, ISO, and other styles

24

Lipeeva, Alla V., Arkady O. Brysgalov, Tatyana G. Tolstikova, and Elvira E. Shults. "Synthesis, Transformations and Characterization of 8 Aminomethyl Substituted Umbelliferones as Probable Anti-Arrhythmic Agents." Current Bioactive Compounds 15, no. 1 (2019): 71–82. http://dx.doi.org/10.2174/1573407213666171030152601.

Full text

Abstract:

Background: Coumarin and modified nitrogen heterocyclic nuclei show biological activity. Combining these into a hybrid molecule could lead to new pharmacological agents. A series of hybrid compounds combining coumarin and piperidine, piperazine, purine or tetrahydroisoquinoline moieties were synthesized and evaluated for anti-arrhythmic activity. Methods: The Mannich reaction of coumarins (peurutenicin, peucenol and 6-cyanoumbelliferrone) with formaldehyde and various amines, including several alkaloids – anabasine, theophylline or tetrahydroisoquinolines, proceeds by heating under reflux in d

APA, Harvard, Vancouver, ISO, and other styles

25

Kashirin, Anton O., Valery A. Polukeev, Anna G. Pshenichnaya, et al. "Behavioral effects of new compounds based on coumarin in rats." Reviews on Clinical Pharmacology and Drug Therapy 18, no. 1 (2020): 37–42. http://dx.doi.org/10.17816/rcf18137-42.

Full text

Abstract:

Introduction. A study of the effects of coumarins has not received widespread use in medicine, largely due to the lack of optimal dosage forms, the creation of which is complicated by their poor solubility in water. Currently, studies are underway on the synthesis of macromolecules, combining various structural fragments, which will lead to increased biological activity of the synthesized coumarin derivatives compared to natural coumarins. The aim of this work was to study the central effect of new coumarin-based compounds: IEM-2262, IEM-2263, IEM-2266, IEM-2267 on emotional and research

APA, Harvard, Vancouver, ISO, and other styles

26

Wu, Bei, Shangli Shi, Huihui Zhang, Baofu Lu, Pan Nan, and Yun A. "Anabolic metabolism of autotoxic substance coumarins in plants." PeerJ 11 (December 6, 2023): e16508. http://dx.doi.org/10.7717/peerj.16508.

Full text

Abstract:

Background Autotoxicity is an intraspecific manifestation of allelopathy in plant species. The specialized metabolites and their derivatives that cause intraspecific allelopathic inhibition in the plant are known as autotoxic substances. Consequently, autotoxic substances production seriously affects the renewal and stability of ecological communities. Methods This article systematically summarizes the types of autotoxic substances present in different plants. They mainly include phenolic compounds, terpenoids, and nitrogenous organic compounds. Phenolic coumarins are the main autotoxic substa

APA, Harvard, Vancouver, ISO, and other styles

27

Kubrak, Tomasz Piotr, Anna Makuch-Kocka, and David Aebisher. "Coumarins in Anticancer Therapy: Mechanisms of Action, Potential Applications and Research Perspectives." Pharmaceutics 17, no. 5 (2025): 595. https://doi.org/10.3390/pharmaceutics17050595.

Full text

Abstract:

Coumarins are natural organic compounds widely found in plants that show promising anticancer properties. This article reviews the current research on the mechanisms of action of coumarins in cancer therapy, including the induction of apoptosis, inhibition of tumor cell proliferation, modulation of oxidative stress, and inhibition of angiogenesis and metastasis. Examples of coumarins with demonstrated anticancer activity, such as scopoletin, umbeliferon, esculetin and their synthetic derivatives, are also presented. The results of preclinical studies, the potential use of coumarins as stand-al

APA, Harvard, Vancouver, ISO, and other styles

28

Gryko, Daniel T. "(Invited) From Head-to-Tail Bis-Coumarins and Conjoined Coumarins to Azacoumarins." ECS Meeting Abstracts MA2025-01, no. 56 (2025): 2702. https://doi.org/10.1149/ma2025-01562702mtgabs.

Full text

Abstract:

Coumarin was first isolated in 1820 from the beans of Dipteryx odorata, which gave its name. The first π-expanded coumarin was synthesized by von Pechmann in 1887. Nevertheless, this field has only catapulted to prominence over the last decade.1 In this short time period, multiple classes of synthesis and characterization of π-expanded coumarins, including conjoined and helical coumarins, have emerged. The growing number of their possible applications, including two-photon fluorescence microscopy, OLEDs, dye-sensitized solar cells, energy and electron transfer systems and fluorescent probes, s

APA, Harvard, Vancouver, ISO, and other styles

29

Sepay, Nayim, Manami Banerjee, Rajibul Islam, Sankar Prasad Dey, and Umesh Chandra Halder. "Crystallography-based exploration of non-covalent interactions for the design and synthesis of coumarin for stronger protein binding." Physical Chemistry Chemical Physics 24, no. 11 (2022): 6605–15. http://dx.doi.org/10.1039/d2cp00082b.

Full text

Abstract:

Investigating 75 crystal structures of different protein–coumarin systems, interacting amino acids, and the types of non-covalent forces between them to design new coumarins with better performance. We synthesized them and tested their performance.

APA, Harvard, Vancouver, ISO, and other styles

30

CAO, Nan-Kai, Yue-Mei CHEN, Si-Si ZHU, et al. "Three new coumarins and a new coumarin glycoside from Micromelum integerrimum." Chinese Journal of Natural Medicines 19, no. 8 (2021): 621–25. http://dx.doi.org/10.1016/s1875-5364(21)60061-4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Rullo, Mariagrazia, Gabriella La Spada, Angela Stefanachi, Eleonora Macchia, Leonardo Pisani, and Francesco Leonetti. "Playing Around the Coumarin Core in the Discovery of Multimodal Compounds Directed at Alzheimer’s-Related Targets: A Recent Literature Overview." Molecules 30, no. 4 (2025): 891. https://doi.org/10.3390/molecules30040891.

Full text

Abstract:

Alzheimer’s disease (AD) causes a great socioeconomic burden because of its increasing prevalence and the lack of effective therapies. The multifactorial nature of AD prompts researchers to search for new strategies for discovering disease-modifying therapeutics. To this extent, the multitarget approach holds the potential of synergic or cooperative activities arising from compounds that are properly designed to address two or more pathogenetic mechanisms. As a privileged and nature-friendly scaffold, coumarin has successfully been enrolled as the heterocyclic core in the design of multipotent

APA, Harvard, Vancouver, ISO, and other styles

32

Kozioł, Ewelina, Krzysztof Jóźwiak, Barbara Budzyńska, Peter A. M. de Witte, Daniëlle Copmans, and Krystyna Skalicka-Woźniak. "Comparative Antiseizure Analysis of Diverse Natural Coumarin Derivatives in Zebrafish." International Journal of Molecular Sciences 22, no. 21 (2021): 11420. http://dx.doi.org/10.3390/ijms222111420.

Full text

Abstract:

Coumarins are a well-known group of plant secondary metabolites with various pharmacological activities, including antiseizure activity. In the search for new antiseizure drugs (ASDs) to treat epilepsy, it is yet unclear which types of coumarins are particularly interesting as a systematic analysis has not been reported. The current study performed behavioral antiseizure activity screening of 18 different coumarin derivatives in the larval zebrafish pentylenetetrazole (PTZ) model using locomotor measurements. Activity was confirmed for seven compounds, which lowered seizure-like behavior as fo

APA, Harvard, Vancouver, ISO, and other styles

33

Cuevas, José María, Rubén Seoane-Rivero, Rodrigo Navarro, and Ángel Marcos-Fernández. "Coumarins into Polyurethanes for Smart and Functional Materials." Polymers 12, no. 3 (2020): 630. http://dx.doi.org/10.3390/polym12030630.

Full text

Abstract:

Polyurethanes are of undoubted interest for the scientific community and the industry. Their outstanding versatility from tailor-made structures turns them into major polymers for use in a wide range of different applications. As with other polymers, new, emerging molecules and monomers with specific attributes can provide new functions and capabilities to polyurethanes. Natural and synthetic coumarin and its derivatives are characterised by interesting biological, photophysical and photochemical properties. Then, the polyurethanes can exploit those features of many coumarins which are present

APA, Harvard, Vancouver, ISO, and other styles

34

Küpeli Akkol, Esra, Yasin Genç, Büşra Karpuz, Eduardo Sobarzo-Sánchez, and Raffaele Capasso. "Coumarins and Coumarin-Related Compounds in Pharmacotherapy of Cancer." Cancers 12, no. 7 (2020): 1959. http://dx.doi.org/10.3390/cancers12071959.

Full text

Abstract:

Cancer is one of the most common causes of disease-related deaths worldwide. Despite the discovery of many chemotherapeutic drugs that inhibit uncontrolled cell division processes for the treatment of various cancers, serious side effects of these drugs are a crucial disadvantage. In addition, multi-drug resistance is another important problem in anticancer treatment. Due to problems such as cytotoxicity and drug resistance, many investigations are being conducted to discover and develop effective anticancer drugs. In recent years, researchers have focused on the anticancer activity coumarins,

APA, Harvard, Vancouver, ISO, and other styles

35

Singh, Parvesh, Nomandla Ngcoya, Ramgopal Mopuri та ін. "α-Glucosidase Inhibition, Antioxidant and Docking Studies of Hydroxycoumarins and their Mono and Bis O-alkylated/acetylated Analogs". Letters in Drug Design & Discovery 15, № 2 (2018): 127–35. http://dx.doi.org/10.2174/1570180814666170602081941.

Full text

Abstract:

Background: Diabetes Mellitus (DM) is a complex metabolic disease illustrated by abnormally high levels of plasma glucose or hyperglycaemia. Accordingly, several α-glucosidase inhibitors have been developed for the treatment of diabetes and other degenerative disorders. While, a coumarin ring has the privilege to represent numerous natural and synthetic compounds with a wide spectrum of biological activities e.g. anti-cancer, anti-HIV, anti-viral, anti-malarial, anti-microbial, anti-convulsant, anti-hypertensive properties. Besides this, coumarins have also shown potential to inhibit α-glucosi

APA, Harvard, Vancouver, ISO, and other styles

36

Klungel, Olaf H., Patrick C. Souverein, Anthonius de Boer, and Tom Schalekamp. "Effect of oral antiplatelet agents on major bleeding in users of coumarins." Thrombosis and Haemostasis 100, no. 12 (2008): 1076–83. http://dx.doi.org/10.1160/th08-05-0290.

Full text

Abstract:

SummaryTreatment with vitamin K antagonists (coumarins) is associated with an increased risk of bleeding. In order to elucidate the bleeding risk of users of antiplatelet drugs among users of coumarins, we assessed the odds ratio of major bleeding associated with use of antiplatelet drugs in users of the coumarins acenocoumarol and phenprocoumon. We used data froma Dutch record linkage system, including pharmacy and linked hospitalization records for approximately two million subjects, to conduct a nested case control study in a cohort of new users of coumarins. Cases were patients who were ho

APA, Harvard, Vancouver, ISO, and other styles

37

Kishkentayeva, Anarkul S., Mohammad Saleh Hamad, Mikhail A. Pokrovsky, et al. "Synthesis and Biological Evaluation of Some Coumarin–Triazole Conjugates as Potential Anticancer Agents." Scientia Pharmaceutica 93, no. 2 (2025): 16. https://doi.org/10.3390/scipharm93020016.

Full text

Abstract:

Despite the discovery of many chemotherapeutic drugs that prevent uncontrolled cell division processes, the development of compounds with higher anticancer efficacy and a lower level of side effects is an important task in modern pharmaceutical chemistry. Herein, a mild and convenient method for the preparation of N1-substituted 3-(1,2,3-triazolyl-methoxycarbonyl)coumarins or bis(coumarine-3-carboxylate)bis(triazole)alkandiyl by the copper(I)-catalyzed Huisgen cycloaddition reaction of readily available coumarin-3-carboxylic acid propynyl ester with azides or diazides has been presented. The s

APA, Harvard, Vancouver, ISO, and other styles

38

Zhang, Changlong, Yang Gao, Yajie Peng, Xiaoqing Zhang, and Hailong Zhang. "A New Coumarin from the Roots of Heracleum dissectum." Natural Product Communications 14, no. 1 (2019): 1934578X1901400. http://dx.doi.org/10.1177/1934578x1901400129.

Full text

Abstract:

A new coumarin with a ferulic acid moiety (1), together with three known coumarins, viz. isoscopletin-6-O- β-D-glucopyranoside (2), elebutheroside B1 (3), tert-O- β-D-glucopyranosyl-(R)-heraclenol (4), were isolated from the roots of Heracleum dissectum. Their structures were clarified by extensive spectroscopic data analysis including 1D and 2D NMR and HRESI MS and comparison with previous literatures (known compounds). Moreover, the absolute configuration of the new compound was also determined.

APA, Harvard, Vancouver, ISO, and other styles

39

Olennikov, Daniil N. "Coumarins of Lovage Roots (Levisticum officinale W.D.J.Koch): LC-MS Profile, Quantification, and Stability during Postharvest Storage." Metabolites 13, no. 1 (2022): 3. http://dx.doi.org/10.3390/metabo13010003.

Full text

Abstract:

Lovage (Levisticum officinale W.D.J. Koch) is a known aromatic apiaceous species that is widely used as a culinary and medicinal plant. Traditionally, more scientific attention has been paid to lovage volatiles, while other groups of compounds have been underutilized. In this study, metabolites of fresh lovage roots were investigated by liquid chromatography–mass spectrometry, and 25 compounds were identified, including coumarins as basic components and minor hydroxycinnamates; most were detected for the first time in the plant. Four major coumarins (including apterin, xanthotoxin, isopimpinel

APA, Harvard, Vancouver, ISO, and other styles

40

Fotopoulos, Ioannis, and Dimitra Hadjipavlou-Litina. "Hybrids of Coumarin Derivatives as Potent and Multifunctional Bioactive Agents: A Review." Medicinal Chemistry 16, no. 3 (2020): 272–306. http://dx.doi.org/10.2174/1573406415666190416121448.

Full text

Abstract:

Background: Coumarins exhibit a plethora of biological activities, e.g. antiinflammatory and anti-tumor. Molecular hybridization technique has been implemented in the design of novel coumarin hybrids with several bioactive groups in order to obtain molecules with better pharmacological activity and improved pharmacokinetic profile. Objective: Therefore, we tried to gather as many as possible biologically active coumarin hybrids referred in the literature till now, to delineate the structural characteristics in relation to the activities and to have a survey that might help the medicinal chemis

APA, Harvard, Vancouver, ISO, and other styles

41

Rohman, Nur, Bayu Ardiansah, Tuti Wukirsari, and Zaher Judeh. "Recent Trends in the Synthesis and Bioactivity of Coumarin, Coumarin–Chalcone, and Coumarin–Triazole Molecular Hybrids." Molecules 29, no. 5 (2024): 1026. http://dx.doi.org/10.3390/molecules29051026.

Full text

Abstract:

Molecular hybridization represents a new approach in drug discovery in which specific chromophores are strategically combined to create novel drugs with enhanced therapeutic effects. This innovative strategy leverages the strengths of individual chromophores to address complex biological challenges, synergize beneficial properties, optimize pharmacokinetics, and overcome limitations associated with single-agent therapies. Coumarins are documented to possess several bioactivities and have therefore been targeted for combination with other active moieties to create molecular hybrids. This review

APA, Harvard, Vancouver, ISO, and other styles

42

Litasova, Elena V., Viktor V. Iljin, Leonid V. Myznikov, Maria A. Brusina, and Levon B. Piotrovskiy. "Coumarins as a base for the drug development: yes or no?" Medical academic journal 22, no. 3 (2022): 27–36. http://dx.doi.org/10.17816/maj87582.

Full text

Abstract:

It is well known that coumarin derivatives are widely distributed in nature and have a wide spectrum of biological activity. At the same time, only a few compounds containing a coumarin fragment are used in the clinics. These compounds include for example the anticoagulant warfarin and the anthelmintic drug haloxon. In the present article is discussed the few examples of biological activity of coumarin derivatives, the mechanisms of action of these compounds and the problems that arise in the development of new drugs, as well as the prospects for using coumarins as leader compounds.

APA, Harvard, Vancouver, ISO, and other styles

43

Scio, Elita, Antônia Ribeiro, Tânia M. A. Alves, et al. "New Bioactive Coumarins fromKielmeyeraalbopunctata." Journal of Natural Products 66, no. 5 (2003): 634–37. http://dx.doi.org/10.1021/np020597r.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Amaro-Luis, Juan, Guillermo Massanet, Enrique Pando, Francisco Rodriguez-Luis, and Eva Zubia. "New Coumarins fromPilocarpus goudotianus." Planta Medica 56, no. 03 (1990): 304–6. http://dx.doi.org/10.1055/s-2006-960965.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Jelali, Hamida, A. Chakchouk-Mtibaa, Lasaad Baklouti, et al. "Development of New Multicomponent Reactions in Eco-Friendly Media-Greener Reaction and Expeditious Synthesis of Novel Bioactive Benzylpyranocoumarins." Journal of Chemistry 2019 (August 21, 2019): 1–10. http://dx.doi.org/10.1155/2019/8693614.

Full text

Abstract:

Multicomponent cyclocondensation of hydrazine derivatives, ethyl acetoacetate, aromatic aldehydes, and 4-hydroxycoumarin has been reported. The optimization details of the developed novel protocol are recorded. The novel procedure features short reaction time, moderate yields, and simple workup. In addition, BMIM[triflate] was chosen as a green solvent. The structures of the obtained benzylpyrazolyl coumarins were determined and confirmed by 1H NMR, 13C NMR, IR, and elemental analysis. The MIC values of benzylpyrazolyl coumarin derivatives were determined by the microbroth dilution method usin

APA, Harvard, Vancouver, ISO, and other styles

46

Souleymane, Coulibaly, Steve-Evanes Koffi Tekib Dindet, Coulibalia Siomenan, Ablo Evrard, and Adjoua Ané. "Synthesis of 6-Phenylethynyl Substituted Coumarins via a Sonogashira Coupling." Pharmaceutical and Chemical Journal 9, no. 2 (2022): 12–23. https://doi.org/10.5281/zenodo.13970387.

Full text

Abstract:

In order to develop a chemical approach to analyze opto-electronic and biological properties of the coumarin scaffold, we focused on the synthesis library of new coumarin analogues. Starting from salicylic aldehyde derivatives, the coumarin scaffold was constructed and functionalized via selective iodination, Knoevenagel condensation and Sonogashira coupling. Our library model proposes the functionalization of three positions of the coumarin backbone. An ester or carboxylic acid at <strong>3</strong>-position, various alkynyl moieties at <strong>6</strong>-position and electrodonating groups (

APA, Harvard, Vancouver, ISO, and other styles

47

Lončarić, Melita, Dajana Gašo-Sokač, Stela Jokić, and Maja Molnar. "Recent Advances in the Synthesis of Coumarin Derivatives from Different Starting Materials." Biomolecules 10, no. 1 (2020): 151. http://dx.doi.org/10.3390/biom10010151.

Full text

Abstract:

The study of coumarin dates back to 1820 when coumarin was first extracted from tonka bean by Vogel. Compounds containing coumarin backbone are a very important group of compounds due to their usage in pharmacy and medicine. Properties and biological activities of coumarin derivatives have a significant role in the development of new drugs. Therefore, many different methods and techniques are developed in order to synthesize coumarin derivatives. Coumarin derivatives could be obtained from different starting materials with various methods but with big differences in yield. This review summariz

APA, Harvard, Vancouver, ISO, and other styles

48

Lončar, Mirjana, Martina Jakovljević, Drago Šubarić, et al. "Coumarins in Food and Methods of Their Determination." Foods 9, no. 5 (2020): 645. http://dx.doi.org/10.3390/foods9050645.

Full text

Abstract:

Coumarin is a natural product with aromatic and fragrant characteristics, widespread in the entire plant kingdom. It is found in different plant sources such as vegetables, spices, fruits, and medicinal plants including all parts of the plants—fruits, roots, stems and leaves. Coumarin is found in high concentrations in certain types of cinnamon, which is one of the most frequent sources for human exposure to this substance. However, human exposure to coumarin has not been strictly determined, since there are no systematic measurements of consumption of cinnamon-containing foods. The addition o

APA, Harvard, Vancouver, ISO, and other styles

49

Kini, Deepthi, та Manjunath Ghate. "Synthesis and Oral Hypoglycemic Activity of 3-[5'-Methyl-2'-aryl-3'-(thiazol-2ʺ-yl amino) thiazolidin-4'-one]coumarin Derivatives". E-Journal of Chemistry 8, № 1 (2011): 386–90. http://dx.doi.org/10.1155/2011/258680.

Full text

Abstract:

Number of heterocyclic compounds has been exploited to develop pharmaceutically important molecules, out of which biheterocyclic coumarins are clinically used potential drug candidates showing oral hypoglycemic and antidiabetic activities. A new series of 3-[5'-methyl-2'-aryl-3'-(thiazol-2ʺ-yl amino)thiazolidin-4'-one]coumarin derivatives were designed and synthesized. The title compounds were synthesized from starting material 3- acetyl coumarin. All the synthesized compounds were characterized and screened for hypoglycemic activity. Some of the compounds exhibited promising activity.

APA, Harvard, Vancouver, ISO, and other styles

50

Bertrand, Cédric, Nicolas Fabre, and Claude Moulis. "A new coumarin glucoside, coumarins and alkaloids from Ruta corsica roots." Fitoterapia 75, no. 2 (2004): 242–44. http://dx.doi.org/10.1016/j.fitote.2003.12.014.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!