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1

Jeyam, Anita. "New diagnostic tools for capture-recapture models." Thesis, University of Kent, 2017. https://kar.kent.ac.uk/64764/.

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Capture-recapture models have increased in complexity over the last decades and goodness-of-fit assessment is crucial to ensure that considered models provide an adequate fit to the data. In this thesis, my primary emphasis is to develop new diagnostic tools for capture-recapture models in order to target possible reasons of lack-of-fit, which might provide biological insights and point towards better-fitting candidate models. Starting with the basic Cormack-Jolly-Seber model, I develop a new tool for detecting heterogeneity in capture. I then progress to the more complex multi-state models, f
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CHIACCHIO, TERESA. "New molecular diagnostic and immunological tools for tuberculosis research." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2009. http://hdl.handle.net/2108/916.

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Tuberculosis (TB) remains one of the world’s leading causes of mortality due to a single infectious agent, with approximately 1.5 million deaths and 9.2 million new cases per year as estimated in 2006. It is assumed that about 5-10% of individuals infected with M. tuberculosis develop TB and the remaining 90-95% contain M. tuberculosis through their immune systems, but have a latent tuberculosis infection (LTBI). To effectively control TB, it is essential to detect individuals with LTBI and to reliably diagnose active TB. Conventional TB diagnosis continues to rely on smear microscopy a
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ALBERTI, Giusi. "Glioblastoma: development of new diagnostic tools based on EV-associated proteins." Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/525186.

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Glioblastomas multiforme (GBM) are the most common malignant primary brain tumors in adults. They are highly aggressive and have an overall survival of <15 months despite maximal surgical resection and chemoradiation (Ostrom, 2019). GBMs are typically heterogeneous with a wide range of genetic and epigenetic variations among tumor cells. Extracellular vesicles (EVs) represent one of the plausible ways through which can be obtained a better understanding of the heterogeneous subpopulations of GBM / molecular signatures. EVs hold promise for the discovery of potential tumours biomarkers useful i
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4

Rodríguez, Pérez Eduardo M. "Study of cow subclinical hypocalcemia and development of new tools for its diagnostic and prevention." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/323908.

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Les vaques de llet sofreixen pèrdues de calci (Ca) quan comença la lactació i poden veure’s afectades per la hipocalcèmia clínica (sèrum Ca < 6mg/dL) o subclínica (Ca < 8.5mg/dL). Donat que la incidència clínica és del 5%, el problema més rellevant es troba en els casos subclínics (SCHC) perquè tenen una prevalença més elevada. Aquests casos no poden ser tractats degut a la falta d’eines de diagnosi. Per tal d’estudiar l’impacte, les conseqüències i la regulació de SCHC, i per desenvolupar estratègies de diagnòstic i de prevenció, es van dur a terme quatre estudis. Al primer estudi, es va aval
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5

Nguyen, Quang Huy. "Genetic determinants and evolution of drug resistance in Mycobacterium tuberculosis in Vietnam : toward new diagnostic tools." Thesis, Montpellier, 2016. http://www.theses.fr/2016MONTT081/document.

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La tuberculose (TB), provoquée par Mycobacterium tuberculosis, est une des trois maladies prioritaires dans le monde. Les TB multi-résistantes (MDR) et ultra-résistantes (XDR-TB) représentent des obstacles majeurs pour la lutte antituberculeuse. Dans les pays à MDR-TB élevée, comme le Vietnam, la détection insuffisante de la résistance aux antibiotiques est un des facteurs principaux qui favorisent la transmission des souches résistantes. De plus, dans ces pays, encore très peu de choses sont connues sur la résistance à la pyrazinamide et aux antibiotiques de seconde ligne et sur les détermina
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6

Calabretta, Maria Maddalena <1986&gt. "New analytical tools and smartphone-based devices exploiting cell-based and bioluminescence detection for environmental and diagnostic applications." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amsdottorato.unibo.it/8640/1/MariaMaddalena_Calabretta.pdf.

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The use of portable light detectors and smart supports and bioinspired materials to confine living cells and use them for field-deployable biosensors has recently attracted much attention. In particular, bioluminescent whole-cell biosensors designed to respond to different analytes or classes of analytes have been successfully implemented in portable and cost-effective analytical devices. The activity carried out during my PhD was mainly focused on the development of whole-cell bioluminescent (BL) biosensors for multi-analyte detection and their implementation into portable analytical devices
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7

Langley, Ivor. "Impact assessment of new tuberculosis diagnostic tools and algorithms to support policy makers in low and middle income countries : an innovative modelling approach." Thesis, University of Warwick, 2016. http://wrap.warwick.ac.uk/87877/.

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In many low and middle income countries the infectious disease tuberculosis is a leading and persistent cause of death, sickness and hardship. This is despite an effective and readily available treatment regimen. Better diagnostics and more rapid initiation of patients onto treatment is essential if the high burden of tuberculosis in these settings is to be substantially reduced, as there is currently no effective vaccine. There is an encouraging pipeline of improved diagnostic tools and algorithms being developed, some of which have been endorsed by the World Health Organization (e.g. Xpert M
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8

Tolstik, Tatiana [Verfasser], Andreas Gutachter] Stallmach, Jürgen [Gutachter] [Popp, and Andrea [Gutachter] Tannapfel. "Development of new classification models based on Raman spectroscopy and MALDI spectrometry as novel tools for liver cancer diagnostic / Tatiana Tolstik ; Gutachter: Andreas Stallmach, Jürgen Popp, Andrea Tannapfel." Jena : Friedrich-Schiller-Universität Jena, 2016. http://d-nb.info/1177610957/34.

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9

VINCI, PAOLA. "From understanding the molecular basis of Graft-versus-Host Disease (GvHD), to new diagnostic tools and innovative treatments for improving the management of patients undergoing allogeneic Hematopoietic Stem Cell Transplantation (HSCT)." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/50969.

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Allogeneic haematopoietic-stem-cell transplantation (HSCT) is the treatment of choice for many malignant and non-malignant disorders. The development of novel strategies such as donor leukocyte infusion, nonmyeloablative HSCT, and cord blood transplantation allowed expanding the indications for allogeneic HSCT over the last several years, especially among older patients. However, the major toxicity of allogeneic HSCT, Graft-versus-Host Disease (GvHD), remains a complication that limits its wider application. Despite advances in post-transplantation immunosuppressive therapy, GvHD remains a maj
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10

Xu, Gaolian. "Developing new synthetic tools for nucleic acid based diagnostics." Thesis, University of Glasgow, 2016. http://theses.gla.ac.uk/7704/.

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With increasing globalization, new infectious diseases are being discovered and spread quickly around the world. The traditional ways for the detection and identification of infectious pathogens are time-consuming and usually require specific facilities. This may delay effective treatment and lead to the spread of infectious disease, especially in the early stages of an epidemic. Therefore, accurate and efficient methods for identification of causative pathogens are very important. Here, we take advantages of new synthetic tools and nucleic acid technologies to develop novel infectious disease
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11

Pratt, Arthur G. "New tools for the diagnosis of early rheumatoid arthritis." Thesis, University of Newcastle Upon Tyne, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.545767.

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12

Mjølstad, Ole Christian. "Pocket-size ultrasound, a new diagnostic tool in clinical practice." Doctoral thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for sirkulasjon og bildediagnostikk, 2013. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-23713.

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13

Valetin, Antonio. "Single pulse stimulation in human symptomatic epilepsy : New diagnostic tool." Thesis, King's College London (University of London), 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498219.

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14

PARRELLA, SARA. "Screening of new candidate DBA genes and development of a new diagnostic tool based on rRNA analysis." Doctoral thesis, Università del Piemonte Orientale, 2016. http://hdl.handle.net/11579/115170.

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15

Yermak, Katsiaryna [Verfasser]. "Evaluation and development of a new diagnostic tool for early and reliable diagnostic of prosthetic joint infection / Katsiaryna Yermak." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2020. http://d-nb.info/1223929000/34.

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16

Shi, Yangyu. "Infrared Imaging Decision Aid Tools for Diagnosis of Necrotizing Enterocolitis." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/40714.

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Neonatal necrotizing enterocolitis (NEC) is one of the most severe digestive tract emergencies in neonates, involving bowel edema, hemorrhage, and necrosis, and can lead to serious complications including death. Since it is difficult to diagnose early, the morbidity and mortality rates are high due to severe complications in later stages of NEC and thus early detection is key to the treatment of NEC. In this thesis, a novel automatic image acquisition and analysis system combining a color and depth (RGB-D) sensor with an infrared (IR) camera is proposed for NEC diagnosis. A design for sensors
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17

Amos-Brown, Bianca. "Isolation and characterisation of novel DNA aptamers against Mycobacterium tuberculosis biomarkers: new tools for tuberculosis diagnostics." Doctoral thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29452.

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Tuberculosis is a curable disease with an average treatment success rate of 86 %. Despite this, there were an estimated 1.5 million deaths due to tuberculosis in 2013, most of which occurred in low and middle income countries. In order to overcome tuberculosis in developing countries innovation in diagnostics is key to administering treatment. While detection of whole mycobacteria has been favoured in the past to diagnose tuberculosis, culturing mycobacteria is costly and microscopy is often not sensitive enough due to low bacterial loads. Detection of Mycobacterium tuberculosis biomarkers in
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18

Merla, Yu. "Development of new on-board battery diagnosis/prognosis tools for extending lifetime and mitigating failure." Thesis, Imperial College London, 2017. http://hdl.handle.net/10044/1/60668.

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Lithium-ion batteries age over their lifetime of operation through various complex degradation mechanisms. In order to maximise battery performance and lifetime, the industrial standard method of measuring the state of health (SOH) by capacity and power fade is no longer good enough. In this thesis, Differential Thermal Voltammetry (DTV) is introduced as a new in-situ diagnosis/prognosis tool that is capable of a more sophisticated diagnosis of SOH, and is application ready with minimal installation costs. DTV uses only cell voltage and surface temperature measurements to infer detailed SOH in
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19

McNabb, Carol Sue 1955. "The correction of faulty finger coordination in bassoon playing: Traditional approaches and a new diagnostic tool." Diss., The University of Arizona, 1996. http://hdl.handle.net/10150/290638.

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This document examines the issue of correcting faulty finger coordination in bassoon playing and describes the development and use of a diagnostic device which allows the player to determine precisely what finger(s) is out of synchronization with the others in transitions from one note to the next. A brief history of movement analysis techniques is given, and several studies of the finger movements of adult musicians which used various types of technology are discussed. In order to understand how movements occur, basic physiological information is provided about the brain, the forearm, the wri
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ALMUJALLY, ABDULLAH MOHAMMED. "Non-Contrast MR-Lymphography: New Tool for Evaluating Lymphedema Pre and Post-Lymph nodal Autotransplantation." Doctoral thesis, Università degli studi di Pavia, 2021. http://hdl.handle.net/11571/1422574.

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MR lymphangiography using dynamic contrast-enhanced images is useful in providing high quality images to diagnose many clinical conditions. However, this procedure cannot be used for traumatic patients or patients with severe side effect of using contrast media. Thus the only option available is to develop a protocol for lymphedema without contrast agents in order to reduce the contra indication of the procedure and to extract diagnostic information without contrast medium. The objectives of this study are to evaluate the role of MR- lymphographic for the assessment of lymphedema before and af
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21

Karsch, Stefan. "High intensity laser generated neutrons a novel neutron source and new tool for plasma diagnostics /." Diss., lmu, 2002. http://nbn-resolving.de/urn:nbn:de:bvb:19-7038.

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22

"van, Wyk BJ, Wyk MA van, and G. Qi. "Difference Histograms: A new tool for time series analysis applied to bearing fault diagnosis." Elsevier, 2008. http://encore.tut.ac.za/iii/cpro/DigitalItemViewPage.external?sp=1001270.

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Abstract A powerful tool for bearing time series feature extraction and classification is introduced that is computationally inexpensive, easy to implement and suitable for real-time applications. In this paper the proposed technique is applied to two rolling element bearing time series classification problems and shown that in some cases no data pre-processing, artificial neural network or nearest neighbour approaches are required. From the results obtained it is clear that for the specific applications considered, the proposed method performed as well as or better than alternative approaches
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23

Serra, Francesca. "The assessment of mood disorders: new methodological perspectives for differential diagnosis." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3426804.

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This dissertation work aims to provide new methodological perspectives in the assessment of mood disorders, with the main task of suggesting effective solutions for the evaluation of major depressive episode (MDE), in order to support the differential diagnosis of different forms of depression. Mood disorders are the most prevalent of all mental health diagnoses and their incidence has increased in recent decades, becoming one of the most significant public health problem. Many people fail to go to school or university, lose their jobs, lose their partner and friends, and may commit suicide.
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CELETTI, GIORGIA. "Microfluidic for human health: a versatile tool for new progress in cancer diagnosis and contaminants detection." Doctoral thesis, Politecnico di Torino, 2016. http://hdl.handle.net/11583/2641069.

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In the last ten years, interest in manipulating droplets in microchannels has emerged from two important motivations. The first arise from the desire to produce well controlled droplets for material science applications, for example in the pharmaceutical or food industries. In this context, microfluidics allows for producing such droplets in a controlled and reproducible manner, also allowing complex combinations to be designed and explored. A second motivation originates with the advent of the -omics era, which has a much need for being able to carry out experiments at the smallest possible s
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Malagón, Rodríguez Marta. "Development of new, non-invasive tools based on faecal bacterial signatures for the early detection of colorectal cancer." Doctoral thesis, Universitat de Girona, 2019. http://hdl.handle.net/10803/669281.

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This thesis aims to develop a new non-invasive tool based on faecal bacterial markers for the early detection of colorectal cancer, which is capable of detecting precancerous lesions before the onset of clinical signs. In this work three tools have been developed: (1) RAID-CRC, based on the combination of four bacterial species with FIT, capable of reducing FIT false positive results in a 50% in a population with symptoms compatible with CRC; (2) RAID-CRC Screen, based on the combination of six bacterial species, capable of reducing I a 20% FIT false positive results in an asymptomatic popula
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Verdonck, Magali. "FTIR imaging: a potential new tool to characterize cancer cells and tumor infiltrating lymphocytes in human breast cancer." Doctoral thesis, Universite Libre de Bruxelles, 2015. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209047.

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Breast cancer is the most common cancer in women. It is a highly heterogeneous disease in terms of histology, therapeutic response and patient outcomes. Early and accurate detection of breast cancer is crucial as the patient prognosis varies greatly depending on the diagnosis of the disease. Nonetheless current breast cancer classification methods fail to precisely sub-classify the disease, resulting in potential inadequate therapeutic management of patients and subsequent poor clinical outcomes. Substantial effort is therefore put in cancer research to develop methods and find new biomarkers
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CAVARRETTA, Elena. "New diagnostic tools for left ventricular hypertrophy: biomolecular and echocardiographic techniques." Doctoral thesis, 2013. http://hdl.handle.net/11573/484068.

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Background: Left ventricular hypertrophy (LVH) is related to different physiological and pathological conditions, as athlete's heart, systemic arterial hypertension, aortic stenosis and hypertrophic cardiomyopathy. The secondary cardiac structural and hemodynamic changes, referred as the “obesity cardiomyopathy” when these alterations result in congestive heart failure, comprise an increase in left ventricular wall thickness, mass and diameters, with systolic and diastolic dysfunction. MicroRNAs are small non-coding RNAs that regulate gene expression by inhibiting RNA translation. In myoc
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Oliveira, Raquel Maria Baptista Lemos Guerra de. "Verbal Memory and Visual Perception in early Alzheimer’s disease: Contribution of new diagnostic tools for new classification criteria." Doctoral thesis, 2016. http://hdl.handle.net/10316/29517.

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Tese de doutoramento em Psicologia, na especialidade de Neuropsicologia, apresentada à Faculdade de Psicologia e de Ciências da Educação da Universidade de Coimbra<br>O envelhecimento da população, como consequência do aumento da esperança média de vida, tem sido acompanhado de um incremento na prevalência das doenças neurodegenerativas. A doença de Alzheimer (DA) é a forma mais prevalente, afectando 5 a 7% das pessoas com mais de 60 anos e sendo responsável por 60 a 70% de todos os casos de demência. A demência em geral, e a DA em particular, são consideradas áreas de intervenção prioritária
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MIGLIORINI, DUCCIO, PAOLO CAPRETTI, and ALBERTO SANTINI. "Phytophthora in natural and anthropic environments: new molecular diagnostic tools for early detection and ecological studies." Doctoral thesis, 2016. http://hdl.handle.net/2158/1028950.

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L’efficacia di PCR quantitativa basata su una sonda TaqMan specifica per il genere è stata confermata come preciso strumento di rilevamento di DNA di Phytophthora su suolo artificialmente infettato, in suolo di invasatura contaminato proveniente da vivaio ed in campioni di trappole aeree. Nessuna quantificazione di DNA è avvenuta dopo due settimane dalla morte indotta del patogeno e, in confronto con i metodi di isolamento tradizionali, è stata dimostrata una significativa maggiore efficienza come strumento diagnostico. La fluttuazione stagionale di Phytophthora in aria è stata quantificata e
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30

Salah, Woubit. "Whole genome sequence of mycoplasma mycoides subsp. Mycoides LC : application to the development of new diagnostic tools and heterologous gene expression." Phd thesis, 2008. http://oatao.univ-toulouse.fr/7645/1/salah.pdf.

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Mycoplasmas are the smallest bacteria without a cell wall derived from Gram positive bacteria. A group of mycoplasma known as the “Mycoplasma mycoides cluster” is composed of five subspecies and an unassigned group of strains known for their pathogenicity in ruminant hosts. Phylogenetically, this cluster is found to be closely related to species of mycoplasma plant pathogens. Mycoplasmas have a reduced genome size of about 1 Mbp, characterized by a low GC content of about 25 %. Among members of the Mycoplasma mycoides cluster, Mycoplasma mycoides subsp. mycoides large colony biotype (MmmLC) is
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31

Reeve, David Mark. "Comparative accuracy and 'field friendly' effectiveness of diagnostic tools for lymphatic filariasis and neurocyticercosis in Papua New Guinea and Timor-Leste with consideration on the impact of parasitic reduction programs." Thesis, 2010. https://researchonline.jcu.edu.au/19042/1/01front.pdf.

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This research has contributed to the field of parasitology by evaluating several diagnostic tests in the area of lymphatic filariasis and determining their suitability for field surveys. A lymphatic filariasis survey in Papua New Guinea (PNG) using the TropBio Assay showed a wide range of prevalence with locations of high prevalence among areas of low prevalence that could be reservoirs of infection if not covered by the filariasis elimination program. Additionally, the results of parasitological surveys conducted in Timor-Leste and PNG are presented, which show the presence of human parasites
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32

Xiang, Xiaoming. "Infrared spectroscopy : new diagnostic tool for periodontitis." 2009. http://hdl.handle.net/1993/21558.

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33

Tedesco, Annarita. "Pathological and therapeutic antibodies: new tools for autoimmunity diagnosis and anticancer therapy." Tesi di dottorato, 2008. http://www.fedoa.unina.it/1959/1/Tedesco_Scienze_Biotecnologiche.pdf.

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34

Bryan, Kelly Asbill. "The development of new tools for field and laboratory diagnosis of Pierces Disease." 2008. http://hdl.handle.net/1969.1/ETD-TAMU-2816.

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Pierce’s Disease (PD), caused by Xylella fastidiosa, is a devastating bacterial disease of grapevines. One of the few control options is roguing. Roguing depends on precise diagnosis of PD in vines. These experiments were conducted to improve available diagnostic protocols and enhance levels of disease control. Plots were selected from four different Texas vineyards with a total of four different varieties (Blanc duBois, Cabernet Sauvignon, Chardonnay, and Merlot). An infrared thermometer was used to take temperature measurements of the vines. Samples were taken of each of these vines at the s
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Ianniello, Davide. "MINI-FLOTAC: A NEW TOOL FOR DIAGNOSIS OF NEMATODES IN SHEEP." Tesi di dottorato, 2015. http://www.fedoa.unina.it/10217/1/Ianniello_Davide_27.pdf.

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In this thesis, the literature review in provides an overview of the main FEC techniques used for GIN in small ruminants (McMaster, FECPAK, Wisconsin, FLOTAC and Mini-FLOTAC). Aspects of these FEC techniques are discussed in more detail. Subsequently, we pay special attention to the variability of FECs due to physical (pre-analytic), laboratory (technical) and biological (host-parasite-related) parameters. Finally, we discuss the use and the interpretation of FECs for small ruminants. This review indicates a lack of detailed studies that focus on (i) diagnostic performance of FEC techniques, (
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Marques, Bruno Filipe Pinheiro. "Urine : a new tool for molecular diagnosis of chronic rejection in kidney transplantation?" Master's thesis, 2015. http://hdl.handle.net/10316/30340.

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Dissertação de mestrado em Biotecnologia Farmacêutica, apresentada à Faculdade de Farmácia da Universidade de Coimbra<br>Renal transplantation has become the treatment of choice for patients with end-stage renal disease. Recognizable improvements in early graft survival and long-term graft function have made kidney transplantation a more cost-effective alternative to dialysis. Moreover, the discovery of new immunosuppressive agents has made a significant impact on short-term graft survival. Despite these improvements a substantial portion of grafts develop progressive dysfunction and fail wit
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Wang, Chien-Chung, and 王建中. "Development of a new tool for Leukemia diagnosis based on Au nano-particle modified QCM biosensor." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/82724394508832591772.

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碩士<br>國立陽明大學<br>醫學生物技術研究所<br>93<br>For molecular diagnosis of the leukemia, both traditional hybridization assay such as FISH and PCR base method require fluorescence or isotope labelling, which is expensive and time-consuming, To meet the growing market needs in the 21st Century, advance devices must link high performance, speed, simplicity and low cost .DNA biosensor is a good candidate for leukemia genetic diagnosis. DNA biosensors draw much attention due to their tremendous promise for obtaining sequence-specific information in a faster, simpler and inexpensive manner compared to tradition
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Karsch, Stefan [Verfasser]. "High intensity laser generated neutrons : a novel neutron source and new tool for plasma diagnostics / vorgelegt von Stefan Karsch." 2002. http://d-nb.info/966646916/34.

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Amadesi, Alessandra. "A FLOTAC and Mini-FLOTAC automated system for parasitological diagnosis in animals. New tools for Faecal Egg Count of gastrointestinal nematodes in ruminants." Tesi di dottorato, 2020. http://www.fedoa.unina.it/13089/7/Amadesi_Alessandra_Tesi_32.pdf.

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This PhD project has allowed to design, project and validate the Kubic FLOTAC Microscope, a new compact, low-cost, versatile digital microscope able to automatically scan the fecal specimens prepared with Mini-FLOTAC or FLOTAC techniques, used for Faecal Egg Count (FEC). This microscope will improve significantly the performances of diagnostic techniques. In this thesis, technical, mechanical, electronical and informatic aspects of Artificial Intelligence and Machine Learning were described. CHAPTER I provides an examination of the most common techniques for copromicroscopic diagnosis of g
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Vannucchi, Giulia. "Depressive and bipolar disorders in persons with intellectual disability and low-functioning autism spectrum disorder. The development and first validation of a new diagnostic tool (SPADD-M)." Doctoral thesis, 2020. http://hdl.handle.net/2158/1188674.

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Background: Current literature reports the frequent co-occurrence of psychiatric disorders (PDs) in adults with Intellectual and Developmental Disorders (IDD), such as Intellectual Disability (ID) and Low-Functioning Autism Spectrum Disorder (LF-ASD). Unfortunately, the adaptations of diagnostic criteria for PDs as well as the standardization of the psychiatric diagnostic process in this population still represent an unmet need, with relevant implications for both the management of mental health issues and the research in this field. In fact, the assessment of PDs in people with IDD requires a
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